Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy

Science Signaling

Volumn 8, Issue 371, 2015, Pages

  So, Jonathan ^a,b   Pasculescu, Adrian ^a   Dai, Anna Y ^a   Williton, Kelly ^a   James, Andrew ^a,f   Nguyen, Vivian ^a   Creixell, Pau ^c   Schoof, Erwin M ^c   Sinclair, John ^d   Barrios Rodiles, Miriam ^a   Gu, Jun ^a,b   Krizus, Aldis ^a,b   Williams, Ryan ^a   Olhovsky, Marina ^a   Dennis, James W ^a,b   Wrana, Jeffrey L ^a,b   Linding, Rune ^c,e   Jorgensen, Claus ^d,g   Pawson, Tony ^a,b   Colwill, Karen ^a  

^a MOUNT SINAI HOSPITAL   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

^d INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^e UNIVERSITY OF COPENHAGEN   (Denmark)

^f Sanofi Pasteur   (Canada)

^g UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AP2 ASSOCIATED KINASE 1; CASPASE; COMPLEMENTARY DNA; CYCLIN DEPENDENT KINASE 5; CYCLIN I; HETEROTRIMERIC GUANINE NUCLEOTIDE BINDING PROTEIN COUPLED RECEPTOR 1; I KAPPA B KINASE BETA; INTEGRIN LINKED KINASE; INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE 4; MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE; PROTEIN ARGININE METHYLTRANSFERASE; PROTEIN ARGININE METHYLTRANSFERASE 5; PROTEIN KINASE; PROTEIN SERINE THREONINE KINASE; PX DOMAIN CONTAINING SERINE THREONINE KINASE; RECEPTOR INTERACTING PROTEIN SERINE THREONINE KINASE 2; RHO KINASE; RHODOPSIN KINASE; ROCK2 PROTEIN; SERINE THREONINE TYROSINE KINASE 1; SMALL INTERFERING RNA; TESTIS SPECIFIC SERINE KINASE 1B; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; TYROSINE KINASE NONRECEPTOR 1; UNCLASSIFIED DRUG; AAK1 PROTEIN, HUMAN; NERVE PROTEIN; PXK PROTEIN, HUMAN; SIGNAL PEPTIDE; TNFSF10 PROTEIN, HUMAN; TUMOR PROTEIN;

APOPTOSIS; ARTICLE; COLON ADENOCARCINOMA; CONTROLLED STUDY; EMBRYO; ENDOCYTOSIS; ENZYME ACTIVATION; ENZYME ANALYSIS; FLOW CYTOMETRY; GENE OVEREXPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; LONG TERMINAL REPEAT; LOSS OF FUNCTION MUTATION; MALE; MASS SPECTROMETRY; MYRISTYLATION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; PROTEOMICS; QUANTITATIVE ANALYSIS; RNA INTERFERENCE; SENSITIZATION; WNT SIGNALING PATHWAY; ADENOCARCINOMA; COLONIC NEOPLASMS; GENETICS; HEK293 CELL LINE; METABOLISM; PATHOLOGY; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

ADENOCARCINOMA; APOPTOSIS; CELL LINE, TUMOR; COLONIC NEOPLASMS; HEK293 CELLS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; NEOPLASM PROTEINS; NERVE TISSUE PROTEINS; PROTEIN-SERINE-THREONINE KINASES; SIGNAL TRANSDUCTION; TNF-RELATED APOPTOSIS-INDUCING LIGAND;

EID: 84927621273     PISSN: 19450877     EISSN: 19379145     Source Type: Journal    
DOI: 10.1126/scisignal.2005700     Document Type: Article

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