TRAIL-related neurotoxicity implies interaction with the Wnt pathway in human neuronal cells in vitro

Journal of Neurochemistry

Volumn 105, Issue 5, 2008, Pages 1915-1923

  Cantarella, Giuseppina ^a   Di Benedetto, Giulia ^a   Pezzino, Salvatore ^a   Risuglia, Nunziata ^a   Bernardini, Renato ^a  

^a UNIVERSITY OF CATANIA   (Italy)

Author keywords

Apoptosis; Glycogen synthase kinase 3 beta; Inflammation; Neurodegeneration; Pharmacological therapy; Signal transduction

Indexed keywords

2 (2,4 DICHLOROPHENYL) 3 (1 METHYL 3 INDOLYL)MALEIMIDE; BETA CATENIN; CASPASE 8 INHIBITOR; GLYCOGEN SYNTHASE KINASE 3BETA; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; WNT PROTEIN;

ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; IN VITRO STUDY; NERVE CELL; NEUROBLASTOMA CELL; NEUROTOXICITY; PRIORITY JOURNAL; PROTEIN INTERACTION; WESTERN BLOTTING;

APOPTOSIS; CELL LINE, TUMOR; HUMANS; NEURONS; SIGNAL TRANSDUCTION; TNF-RELATED APOPTOSIS-INDUCING LIGAND; WNT PROTEINS;

MOUSE MAMMARY TUMOR VIRUS;

EID: 43549085722     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2008.05291.x     Document Type: Article

References (37)

1. Aberle H., Bauer A., Stappert J., Kispert A. Kemler R. (1997) Beta-catenin is a target for the ubiquitin-proteasome pathway. EMBO J. 16, 3797 3804.
2. Aza-Blanc P., Cooper C. L., Wagner K., Batalov S., Deveraux Q. L. Cooke M. P. (2003) Identification of modulators of TRAIL-induced apoptosis via RNAi-based phenotypic screening. Mol. Cell 12, 627 637.
3. Behrens J., von Kries J. P., Kuhl M., Bruhn L., Wedlich D., Grosschedl R. Birchmeier W. (1996) Functional interaction of beta-catenin with the transcription factor LEF-1. Nature 382, 638 642.
4. Bradford M. M. (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72, 248 254.
5. Brown J. D. Moon R. T. (1998) Wnt signaling: why is everything so negative? Curr. Opin. Cell Biol. 10, 182 187.
6. Cantarella G., Uberti D., Carsana T., Lombardo G., Bernardini R. Memo M. (2003) Neutralization of TRAIL death pathway protects human neuronal cell line from β-amyloid toxicity. Cell Death Diff. 10, 134 141.
7. Cantarella G., Risuglia N., Lombardo G., Lempereur L., Nicoletti F., Memo M. Bernardini R. (2004) Protective effects of estradiol on TRAIL-induced apoptosis in a human oligodendrocytic cell line: evidence for multiple sites of interactions. Cell Death Differ. 11, 503 511.
8. Caricasole A., Copani A., Caruso A., Caraci F., Iacovelli L., Sortino M. A., Terstappen G. C. Nicoletti F. (2003) The Wnt pathway, cell-cycle activation and beta-amyloid: novel therapeutic strategies in Alzheimer's disease? Trends Pharmacol. Sci. 24, 233 238.
9. Cotter D., Kerwin R., al-Sarraji S., Brion J. P., Chadwich A., Lovestone S., Anderton B. Everall I. (1998) Abnormalities of Wnt signalling in schizophrenia - evidence for neurodevelopmental abnormality. Neuroreport 9, 1379 1383.
10. Cruz J. C., Tseng H. C., Goldman J. A., Shih H. Tsai L. H. (2003) Aberrant Cdk5 activation by p25 triggers pathological events leading to neurodegeneration and neurofibrillary tangles. Neuron 40, 471 483.
11. Dale T. C. (1998) Signal transduction by the Wnt family of ligands. Biochem. J. 329, 209 223.
12. De Ferrari G. V., Chacon M. A., Barria M. I., Garrido J. L., Godoy J. A., Olivares G., Reyes A. E., Alvarez A., Bronfman M. Inestrosa N. C. (2003) Activation of Wnt signaling rescues neurodegeneration and behavioral impairments induced by beta-amyloid fibrils. Mol. Psychiatry 8, 195 208.
13. van Es J. H., Barker N. Clevers H. (2003) You Wnt some, you lose some: oncogenes in the Wnt signaling pathway. Curr. Opin. Genet. Dev. 13, 28 33.
14. Flaherty D. B., Soria J. P., Tomasiewicz H. G. Wood J. G. (2000) Phosphorylation of human tau protein by microtubule-associated kinases: GSK3beta and cdk5 are key participants. J. Neurosci. Res. 62, 463 472.
15. Hardy J. (2003) The relationship between amyloid and tau. J. Mol. Neurosci. 20, 203 206.
16. Hardy J. A. Higgins G. A. (1992) Alzheimer's disease: the amyloid cascade hypothesis. Science 256, 184 185.
17. Ho G. J., Drego R., Hakimian E. Masliah E. (2005) Mechanisms of cell signaling and inflammation in Alzheimer's disease. Curr. Drug Targets Inflamm. Allergy 4, 247 256.
18. Huang Y., Erdmann N., Peng H., Zhao Y. Zheng J. (2005) The role of TNF related apoptosis-inducing ligand in neurodegenerative diseases. Cell Mol. Immunol. 2, 113 122.
19. Inestrosa N., De Ferrari G. V., Garrido J. L., Alvarez A., Olivares G. H., Barria M. I., Bronfman M. Chacon M. A. (2002) Wnt signaling involvement in beta-amyloid-dependent neurodegeneration. Neurochem. Int. 41, 341 344.
20. Inestrosa N. C., Varela-Nallar L., Grabowski C. P. Colombres M. (2007) Synaptotoxicity in Alzheimer's disease: the Wnt signaling pathway as a molecular target. IUBMB Life 59, 316 321.
21. Jurewicz A., Matysiak M., Andrzjak S. Selmaj K. (2006) Trail-induced death of human adult oligodendrocytes is mediated by JNK pathway. GLIA 53, 158 166.
22. Kim H. S., Kim E. M., Lee J. P. et al. (2003) C-terminal fragments of amyloid precursor protein exert neurotoxicity by inducing glycogen synthase kinase-3beta expression. FASEB J. 17, 1951 1953.
23. Lai J. S., Zhao C., Warsh J. J. Li P. P. (2006) Cytoprotection by lithium and valproate varies between cell types and cellular stresses. Eur. J. Pharmacol. 539, 18 26.
24. Liu F., Iqbal K., Grundke-Iqbal I. Gong C. X. (2002) Involvement of aberrant glycosylation in phosphorylation of tau by cdk5 and GSK-3beta. FEBS Lett. 530, 209 214.
25. Lucas J. J., Hernandez F., Gomez-Ramos P., Moran M. A., Hen R. Avila J. (2001) Decreased nuclear beta-catenin, tau hyperphosphorylation and neurodegeneration in GSK-3beta conditional transgenic mice. EMBO J. 20, 27 39.
26. Malaterre J., Ramsay R. G. Mantamadiotis T. (2007) Wnt-Frizzled signalling and the many paths to neural development and adult brain homeostasis. Front. Biosci. 12, 492 506.
27. Mandelkow E. M. Mandelkow E. (1998) Tau in Alzheimer's disease. Trends Cell Biol. 8, 425 427.
28. Pan G., O'Rourke K., Chinnaiyan A. M., Gentz R., Ebner R., Ni J. Dixit V. M. (1997) The receptor for the cytotoxic ligand TRAIL. Science 276, 111.
29. Reynolds C. H., Utton M. A., Gibb G. M., Yates A. Anderton B. H. (1997) Stress-activated protein kinase/c-jun N-terminal kinase phosphorylates tau protein. J. Neurochem. 68, 1736 1744.
30. Selkoe D. J. (2000) The origins of Alzheimer's disease: A is for amyloid. JAMA 283, 1615 1617.
31. Sobue K., Agarwal-Mawal A., Li W., Sun W., Miura Y. Paudel H. K. (2000) Interaction of neuronal Cdc2-like protein kinase with microtubule-associated protein tau. J. Biol. Chem. 275, 16673 16680.
32. Takashima A., Honda T., Yasutake K., Michel G., Murayama O., Murayama M., Ishiguro K. Yamaguchi H. (1998) Activation of tau protein kinase I/glycogen synthase kinase-3beta by amyloid beta peptide (25-35) enhances phosphorylation of tau in hippocampal neurons. Neurosci. Res. 31, 317 323.
33. Tuppo E. E. Arias H. R. (2005) The role of inflammation in Alzheimer's disease. Int. J. Biochem. Cell Biol. 37, 289 305.
34. Wang Q., Zhou Y., Wang X. Evers B. M. (2006) Glycogen synthase kinase-3 is a negative regulator of extracellular signal-regulated kinase. Oncogene 25, 43 50.
35. Wassink T. H., Piven J., Vieland V. J. et al. (2001) Evidence supporting WNT2 as an autism susceptibility gene. Am. J. Med. Genet. 105, 406 413.
36. Willert K. Nusse R. (1998) Beta-catenin: a key mediator of Wnt signaling. Curr. Opin. Genet. Dev. 8, 95 102.
37. Yamanaka H., Moriguchi T., Masuyama N., Kusakabe M., Hanafusa H., Takada R., Takada S. Nishida E. (2002) JNK functions in the non-canonical Wnt pathway to regulate convergent extension movements in vertebrates. EMBO Rep. 3, 69 75.