Validating Aurora B as an anti-cancer drug target

Journal of Cell Science

Volumn 119, Issue 17, 2006, Pages 3664-3675

  Girdler, Fiona ^a   Gascoigne, Karen E ^a   Eyers, Patrick A ^a   Hartmuth, Sonya ^a   Crafter, Claire ^b   Foote, Kevin M ^b   Keen, Nicholas J ^b   Taylor, Stephen S ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b ASTRAZENECA   (United Kingdom)

Author keywords

Chemical genetics; Drug resistance; Hesperadin; VX 680; ZM447439

Indexed keywords

ANTINEOPLASTIC AGENT; AURORA A KINASE; AURORA B KINASE; MONASTROL; MUTANT PROTEIN; N [4 [6 METHOXY 7 (3 MORPHOLINOPROPOXY) 4 QUINAZOLINYLAMINO]PHENYL]BENZAMIDE; NOCODAZOLE; PACLITAXEL; PHOSPHOTRANSFERASE INHIBITOR; UNCLASSIFIED DRUG; ZM 2; ZM 3; ZN 2;

ARTICLE; CATALYSIS; CELL DIVISION; CELL POLARITY; CELL VIABILITY; CHROMOSOME ANALYSIS; CONTROLLED STUDY; CYTOKINESIS; DRUG MECHANISM; DRUG RESEARCH; DRUG STRUCTURE; DRUG TARGETING; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; IN VITRO STUDY; MITOSIS; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; VALIDATION STUDY;

ANIMALS; ANTINEOPLASTIC AGENTS; BENZAMIDES; CELL DIVISION; CELL POLARITY; CELL PROLIFERATION; CELL SURVIVAL; DRUG DESIGN; HUMANS; MITOTIC SPINDLE APPARATUS; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; NEOPLASMS; PHENOTYPE; PROTEIN-SERINE-THREONINE KINASES; QUINAZOLINES;

EID: 33749409412     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: 10.1242/jcs.03145     Document Type: Article

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