Accumulation of driver and passenger mutations during tumor progression

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 43, 2010, Pages 18545-18550

  Bozic, Ivana ^a,b   Antal, Tibor ^a,c   Ohtsuki, Hisashi ^d   Carter, Hannah ^e   Kim, Dewey ^e   Chen, Sining ^f   Karchin, Rachel ^e   Kinzler, Kenneth W ^g   Vogelstein, Bert ^g   Nowak, Martin A ^a,b  

^a HARVARD UNIVERSITY   (United States)

^b HARVARD UNIVERSITY   (United States)

^c UNIVERSITY OF EDINBURGH   (United Kingdom)

^d Johns Hopkins University ^*  (Japan)

^e Johns Hopkins University School of Medicine   (United States)

^f UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY   (United States)

^g JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

Genetics; Mathematical biology

Indexed keywords

ARTICLE; CLONAL VARIATION; DRIVER TUMOR GENE; GENE FUNCTION; GENE MUTATION; GENETIC HETEROGENEITY; MATHEMATICAL MODEL; PRIORITY JOURNAL; TUMOR GENE; TUMOR GROWTH; TUMOR MODEL; TUMOR VOLUME;

ADENOMATOUS POLYPOSIS COLI; COMPUTER SIMULATION; DISEASE PROGRESSION; GENES, APC; GENES, TUMOR SUPPRESSOR; GENETICS, POPULATION; GENOMICS; HUMANS; MODELS, GENETIC; MOLECULAR BIOLOGY; MUTATION; NEOPLASMS; NEOPLASTIC PROCESSES; ONCOGENES; STOCHASTIC PROCESSES; TIME FACTORS;

EID: 78249261016     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1010978107     Document Type: Article

References (44)

1. Vogelstein B, Kinzler KW (2004) Cancer genes and the pathways they control. Nat Med 10:789-799. (Pubitemid 39070849)
2. Greenman C, et al. (2007) Patterns of somatic mutation in human cancer genomes. Nature 446:153-158.
3. Collins FS, Barker AD (2007) Mapping the cancer genome. Sci Am 296:50-57.
4. Ley TJ, et al. (2008) DNA sequencing of a cytogenetically normal acute myeloid leukemia genome. Nature 456:66-72.
5. Mardis ER, et al. (2009) Recurring mutations found by sequencing an acute myeloid leukemia genome. N Engl J Med 361:1058-66.
6. Sjoblom T, et al. (2006) The consensus coding sequences of human breast and colorectal cancers. Science 314:268-274.
7. Wood L, et al. (2007) The genomic landscapes of human breast and colorectal cancers. Science 318:1108-1113. (Pubitemid 350134889)
8. Parsons DW, et al. (2008) An integrated genomic analysis of human glioblastoma multiforme. Science 321:1807-1812.
9. Jones S, et al. (2008) Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. Science 321:1801-1806.
10. Teschendorff AE, Caldas C (2009) The breast cancer somatic "muta-ome": Tackling the complexity. Breast Cancer Res 11:301.
11. Simpson AJ (2009) Sequence-based advances in the definition of cancer-associated gene mutations. Curr Opin Oncol 21:47-52.
12. Maley CC, et al. (2004) Selectively advantageous mutations and hitchhikers in neoplasms: p16 lesions are selected in Barrett's Esophagus. Cancer Res 64:3414-3427.
13. Haber DA, Settleman J (2007) Cancer: Drivers and passengers. Nature 446:145-146.
14. Nowak MA, et al. (2002) The role of chromosomal instability in tumor initiation. Proc Natl Acad Sci USA 99:16226-16231.
15. Nowak MA, Michor F, Iwasa Y (2004) Evolutionary dynamics of tumor suppressor gene inactivation. Proc Natl Acad Sci USA 101:10635-10638. (Pubitemid 38955794)
16. Durrett R, Schmidt D, Schweinsberg J (2009) A waiting time problem arising from the study of multi-stage carcinogenesis. Ann Appl Probab 19:676-718.
17. Iwasa Y, Nowak MA, Michor F (2006) Evolution of resistance during clonal expansion. Genetics 172:2557-2566.
18. Haeno H, Iwasa Y, Michor F (2007) The evolution of two mutations during clonal expansion. Genetics 177:2209-2221.
19. Dewanji A, Luebeck EG, Moolgavkar SH (2005) A generalized Luria-Delbruck model. Math Biosci 197:140-152.
20. Komarova NL, Wu L, Baldi P (2007) The fixed-size Luria-Delbruck model with a nonzero death rate. Math Biosci 210:253-290.
21. Meza R, Jeon J, Moolgavkar SH, Luebeck G (2008) Age-specific incidence of cancer: Phases, transitions, and biological implications. Proc Natl Acad Sci USA 105:16284-16289.
22. Beerenwinkel N, et al. (2007) Genetic progression and the waiting time to cancer. PLoS Comput Biol 3:e225.
23. Durrett R, Moseley S (2010) The evolution of resistance and progression to disease during clonal expansion of cancer. Theor Popul Biol 77:42-48.
24. Knudson AG (1971) Mutation and cancer: Statistical study of retinoblastoma. Proc Natl Acad Sci USA 68:820-823.
25. Athreya KB, Ney PE (1972) Branching Processes (Springer, New York).
26. Jones S, et al. (2008) Comparative lesion sequencing provides insights into tumor evolution. Proc Natl Acad Sci USA 105:4283-4288.
27. Lengauer C, Kinzler KW, Vogelstein B (1998) Genetic instabilities in human cancers. Nature 396:643-649.
28. Hoshino T, Wilson CB (1979) Cell kinetic analyses of human malignant brain tumors (gliomas). Cancer 44:956-962. (Pubitemid 10242229)
29. Louis DN, et al. (2007) The 2007 WHO classification of tumors of the central nervous system. Acta Neuropathol 114:97-109. (Pubitemid 47103521)
30. Mimeault M, Brand RE, Sasson AA, Batra SK (2005) Recent advances on the molecular mechanisms involved in pancreatic cancer progression and therapies. Pancreas 31:301-316. (Pubitemid 41566878)
31. Kraus-Ruppert R, Laissue J, Odartchenko N (1973) Proliferation and turnover of glial cells in the forebrain of young adult mice as studied by repeated injections of 3H-Thymidine over a prolonged period of time. J Comp Neurol 148:211-216.
32. Klein WM, Hruban RH, Klein-Szanto AJP, Wilentz RE (2002) Direct correlation between proliferative activity and displasia in pancreatic intraepithelial neoplasia (PanIN): Additional evidence for a recently proposed model of progression. Mod Pathol 15:441-447.
33. Carter H, et al. (2009) Cancer-specific high-throughput annotation of somatic mutations: Computational prediction of driver missense mutations. Cancer Res 69:6660-6667.
34. Breiman L (2001) Random forest. Mach Learn 45:5-32.
35. Forbes SA, et al. (2010) COSMIC (the Catalogue of Somatic Mutations in Cancer): A resource to investigate acquired mutations in human cancer. Nucleic Acids Res 38(Database issue):D652-657.
36. UniProt Consortium (2010) The universal protein resource (UniProt) in 2010. Nucleic Acids Res 38(Database issue):D142-148.
37. Giardiello FM, et al. (1993) Treatment of colonic and rectal adenomas with sulindac in familial adenomatous polyposis. N Engl J Med 328:1313-1316.
38. Giardiello FM, et al. (2002) Primary chemoprevention of familial adenomatous polyposis with sulindac. N Engl J Med 346:1054-1059.
39. Muto T, Bussey JR, Morson B (1975) The evolution of cancer of the colon and rectum. Cancer 36:2251-2270.
40. Potten CS, Booth C, Hargreaves D (2003) The small intestine as a model for evaluating adult tissue stem cell drug targets. Cell Proliferat 36:115-129.
41. Moolgavkar SH, Luebeck EG (1992) Multistage carcinogenesis: Population-based model for colon cancer. J Natl Cancer Inst 84:610-618.
42. Armitage P, Doll R (2004) The age distribution of cancer and a multi-stage theory of carcinogenesis. Int J Epidemiol 33:1174-1179. (Pubitemid 40124910)
43. Moolgavkar SH, Knudson AG (1981) Mutation and cancer: A model for human carcinogenesis. J Natl Cancer Inst 66:1037-1052.
44. Huang J, et al. (1996) APC mutations in colorectal tumors with mismatch-repair deficiency. Proc Natl Acad Sci USA 93:9049-9054.