-
1
-
-
13344285339
-
Identification and characterization of a new member of the TNF family that induces apoptosis
-
Wiley SR, Schooley K, Smolak PJ, et al. Identification and characterization of a new member of the TNF family that induces apoptosis. Immunity 1995;3:673-682
-
(1995)
Immunity
, vol.3
, pp. 673-682
-
-
Wiley, S.R.1
Schooley, K.2
Smolak, P.J.3
-
2
-
-
58149116500
-
TNFSF10 (TRAIL), a p53 target gene that mediates p53-dependent cell death
-
Kuribayashi K, Krigsfeld G, Wang W, et al. TNFSF10 (TRAIL), a p53 target gene that mediates p53-dependent cell death. Cancer Biol Ther 2008;7:2034-2038
-
(2008)
Cancer Biol Ther
, vol.7
, pp. 2034-2038
-
-
Kuribayashi, K.1
Krigsfeld, G.2
Wang, W.3
-
3
-
-
0142091494
-
Egr family members regulate nonlymphoid expression of Fas ligand, TRAIL, and tumor necrosis factor during immune responses
-
Droin NM, Pinkoski MJ, Dejardin E, Green DR. Egr family members regulate nonlymphoid expression of Fas ligand, TRAIL, and tumor necrosis factor during immune responses. Mol Cell Biol 2003;23:7638-7647
-
(2003)
Mol Cell Biol
, vol.23
, pp. 7638-7647
-
-
Droin, N.M.1
Pinkoski, M.J.2
Dejardin, E.3
Green, D.R.4
-
4
-
-
4143116932
-
Tumor suppressor IRF-1 mediates retinoid and interferon anticancer signaling to death ligand TRAIL
-
Clarke N, Jimenez-Lara AM, Voltz E, Gronemeyer H. Tumor suppressor IRF-1 mediates retinoid and interferon anticancer signaling to death ligand TRAIL. EMBO J 2004;23:3051-3060
-
(2004)
EMBO J
, vol.23
, pp. 3051-3060
-
-
Clarke, N.1
Jimenez-Lara, A.M.2
Voltz, E.3
Gronemeyer, H.4
-
5
-
-
0035067368
-
Regulation of death receptor expression and TRAIL/Apo2L-induced apoptosis by NF-kappaB
-
Ravi R, Bedi GC, Engstrom LW, et al. Regulation of death receptor expression and TRAIL/Apo2L-induced apoptosis by NF-kappaB. Nat Cell Biol 2001;3:409-416
-
(2001)
Nat Cell Biol
, vol.3
, pp. 409-416
-
-
Ravi, R.1
Bedi, G.C.2
Engstrom, L.W.3
-
6
-
-
53049107304
-
Sp1-mediated TRAIL induction in chemosensitization
-
Xu J, Zhou JY, Wei WZ, et al. Sp1-mediated TRAIL induction in chemosensitization. Cancer Res 2008;68:6718-6726
-
(2008)
Cancer Res
, vol.68
, pp. 6718-6726
-
-
Xu, J.1
Zhou, J.Y.2
Wei, W.Z.3
-
7
-
-
70450267416
-
PU.1 induces apoptosis in myeloma cells through direct transactivation of TRAIL
-
Ueno S, Tatetsu H, Hata H, et al. PU.1 induces apoptosis in myeloma cells through direct transactivation of TRAIL. Oncogene 2009;28:4116-4125
-
(2009)
Oncogene
, vol.28
, pp. 4116-4125
-
-
Ueno, S.1
Tatetsu, H.2
Hata, H.3
-
8
-
-
0033662433
-
Apo2L/TRAIL-dependent recruitment of endogenous FADD and caspase-8 to death receptors 4 and 5
-
Kischkel FC, Lawrence DA, Chuntharapai A, et al. Apo2L/TRAIL-dependent recruitment of endogenous FADD and caspase-8 to death receptors 4 and 5. Immunity 2000;12:611-620
-
(2000)
Immunity
, vol.12
, pp. 611-620
-
-
Kischkel, F.C.1
Lawrence, D.A.2
Chuntharapai, A.3
-
9
-
-
0037099678
-
C-FLIPL is a dual function regulator for caspase-8 activation and CD95-mediated apoptosis
-
Chang DW, Xing Z, Pan Y, et al. c-FLIPL is a dual function regulator for caspase-8 activation and CD95-mediated apoptosis. EMBO J 2002;21(14):3704-3714
-
(2002)
EMBO J
, vol.21
, Issue.14
, pp. 3704-3714
-
-
Chang, D.W.1
Xing, Z.2
Pan, Y.3
-
10
-
-
65549085701
-
Cullin3-based polyubiquitination and p62-dependent aggregation of caspase-8 mediate extrinsic apoptosis signaling
-
Jin Z, Li Y, Pitti R, et al. Cullin3-based polyubiquitination and p62-dependent aggregation of caspase-8 mediate extrinsic apoptosis signaling. Cell 2009;137:721-735
-
(2009)
Cell
, vol.137
, pp. 721-735
-
-
Jin, Z.1
Li, Y.2
Pitti, R.3
-
11
-
-
0036479001
-
And all of a sudden its over: Mitochondrial outer-membrane permeabilization in apoptosis
-
Waterhouse NJ, Ricci JE, Green DR. And all of a sudden its over: mitochondrial outer-membrane permeabilization in apoptosis. Biochimie 2002;84:113-121
-
(2002)
Biochimie
, vol.84
, pp. 113-121
-
-
Waterhouse, N.J.1
Ricci, J.E.2
Green, D.R.3
-
12
-
-
3343011970
-
Caspase activation, inhibition, and reactivation: A mechanistic view
-
Shi Y. Caspase activation, inhibition, and reactivation: a mechanistic view. Protein Sci 2004;13:1979-1987
-
(2004)
Protein Sci
, vol.13
, pp. 1979-1987
-
-
Shi, Y.1
-
13
-
-
2342459790
-
DNA damage-induced apoptosis
-
Norbury CJ, Zhivotovsky B. DNA damage-induced apoptosis. Oncogene 2004;23:2797-2808
-
(2004)
Oncogene
, vol.23
, pp. 2797-2808
-
-
Norbury, C.J.1
Zhivotovsky, B.2
-
14
-
-
18144416502
-
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) induces rheumatoid arthritis synovial fibroblast proliferation through mitogen-activated protein kinases and phosphatidylinositol 3-kinase/Akt
-
Morel J, Audo R, Hahne M, Combe B. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) induces rheumatoid arthritis synovial fibroblast proliferation through mitogen-activated protein kinases and phosphatidylinositol 3-kinase/Akt. J Biol Chem 2005;280:15709-15718
-
(2005)
J Biol Chem
, vol.280
, pp. 15709-15718
-
-
Morel, J.1
Audo, R.2
Hahne, M.3
Combe, B.4
-
15
-
-
24744462114
-
Tumor necrosis factor-related apoptosis-inducing ligand-mediated proliferation of tumor cells with receptor-proximal apoptosis defects
-
Baader E, Toloczko A, Fuchs U, et al. Tumor necrosis factor-related apoptosis-inducing ligand-mediated proliferation of tumor cells with receptor-proximal apoptosis defects. Cancer Res 2005;65:7888-7895
-
(2005)
Cancer Res
, vol.65
, pp. 7888-7895
-
-
Baader, E.1
Toloczko, A.2
Fuchs, U.3
-
16
-
-
0038339094
-
TRAIL induced survival and proliferation in cancer cells resistant towards TRAIL-induced apoptosis mediated by NF-kappaB
-
Ehrhardt H, Fulda S, Schmid I, et al. TRAIL induced survival and proliferation in cancer cells resistant towards TRAIL-induced apoptosis mediated by NF-kappaB. Oncogene 2003;22:3842-3852
-
(2003)
Oncogene
, vol.22
, pp. 3842-3852
-
-
Ehrhardt, H.1
Fulda, S.2
Schmid, I.3
-
18
-
-
1542513774
-
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is required for induction of autophagy during lumen formation in vitro
-
Mills KR, Reginato M, Debnath J, et al. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is required for induction of autophagy during lumen formation in vitro. Proc Natl Acad Sci USA 2004;101:3438-3443
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 3438-3443
-
-
Mills, K.R.1
Reginato, M.2
Debnath, J.3
-
19
-
-
0036467427
-
Increased susceptibility to tumor initiation and metastasis in TNF-related apoptosis-inducing ligand-deficient mice
-
Cretney E, Takeda K, Yagita H, et al. Increased susceptibility to tumor initiation and metastasis in TNF-related apoptosis-inducing ligand-deficient mice. J Immunol 2002;168:1356-1361
-
(2002)
J Immunol
, vol.168
, pp. 1356-1361
-
-
Cretney, E.1
Takeda, K.2
Yagita, H.3
-
20
-
-
0035137696
-
Involvement of tumor necrosis factor-related apoptosis-inducing ligand in surveillance of tumor metastasis by liver natural killer cells
-
DOI 10.1038/83416
-
Takeda K, Hayakawa Y, Smyth MJ, et al. Involvement of tumor necrosis factor-related apoptosis-inducing ligand in surveillance of tumor metastasis by liver natural killer cells. Nat Med 2001;7:94-100 (Pubitemid 32095647)
-
(2001)
Nature Medicine
, vol.7
, Issue.1
, pp. 94-100
-
-
Takeda, K.1
Hayakawa, Y.2
Smyth, M.J.3
Kayagaki, N.4
Yamaguchi, N.5
Kakuta, S.6
Iwakura, Y.7
Yagita, H.8
Okumura, K.9
-
21
-
-
0035339858
-
The involvement of TNF-alpha-related apoptosis-inducing ligand in the enhanced cytotoxicity of IFN-beta-stimulated human dendritic cells to tumor cells
-
Liu S, Yu Y, Zhang M, et al. The involvement of TNF-alpha-related apoptosis-inducing ligand in the enhanced cytotoxicity of IFN-beta-stimulated human dendritic cells to tumor cells. J Immunol 2001;166:5407-5415
-
(2001)
J Immunol
, vol.166
, pp. 5407-5415
-
-
Liu, S.1
Yu, Y.2
Zhang, M.3
-
22
-
-
0037240850
-
Natures TRAIL - on a path to cancer immunotherapy
-
Smyth MJ, Takeda K, Hayakawa Y, et al. Natures TRAIL - on a path to cancer immunotherapy. Immunity 2003;18:1-6
-
(2003)
Immunity
, vol.18
, pp. 1-6
-
-
Smyth, M.J.1
Takeda, K.2
Hayakawa, Y.3
-
23
-
-
14844297325
-
The role of tumor stroma in the interaction between tumor and immune system
-
Blankenstein T. The role of tumor stroma in the interaction between tumor and immune system. Curr Opin Immunol 2005;17:180-186
-
(2005)
Curr Opin Immunol
, vol.17
, pp. 180-186
-
-
Blankenstein, T.1
-
24
-
-
33747586281
-
The potential of the tumor microenvironment to influence Apo2L/TRAIL induced apoptosis
-
Mace TA, Yamane N, Cheng J, et al. The potential of the tumor microenvironment to influence Apo2L/TRAIL induced apoptosis. Immunol Invest 2006;35:279-296
-
(2006)
Immunol Invest
, vol.35
, pp. 279-296
-
-
MacE, T.A.1
Yamane, N.2
Cheng, J.3
-
25
-
-
39749132878
-
The von hippel-lindau tumor suppressor protein: An update
-
Kaelin WG Jr. The von hippel-lindau tumor suppressor protein: an update. Methods Enzymol 2007;435:371-383
-
(2007)
Methods Enzymol
, vol.435
, pp. 371-383
-
-
Kaelin Jr., W.G.1
-
26
-
-
3042665524
-
Hypoxia inhibits tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by blocking Bax translocation
-
Kim M, Park SY, Pai HS, et al. Hypoxia inhibits tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by blocking Bax translocation. Cancer Res 2004;64:4078-4081
-
(2004)
Cancer Res
, vol.64
, pp. 4078-4081
-
-
Kim, M.1
Park, S.Y.2
Pai, H.S.3
-
27
-
-
33845221022
-
TRAIL promotes metastasis of human pancreatic ductal adenocarcinoma
-
Trauzold A, Siegmund D, Schniewind B, et al. TRAIL promotes metastasis of human pancreatic ductal adenocarcinoma. Oncogene 2006;25:7434-7439
-
(2006)
Oncogene
, vol.25
, pp. 7434-7439
-
-
Trauzold, A.1
Siegmund, D.2
Schniewind, B.3
-
28
-
-
19544390527
-
Soluble TRAIL concentrations are raised in patients with systemic lupus erythematosus
-
Lub-de Hooge MN, de Vries EG, de Jong S, Bijl M. Soluble TRAIL concentrations are raised in patients with systemic lupus erythematosus. Ann Rheum Dis 2005;64:854-858
-
(2005)
Ann Rheum Dis
, vol.64
, pp. 854-858
-
-
Lub-De Hooge, M.N.1
De Vries, E.G.2
De Jong, S.3
Bijl, M.4
-
29
-
-
12444304354
-
TNF-related apoptosis inducing ligand (TRAIL) as a potential response marker for interferon-beta treatment in multiple sclerosis
-
Wandinger KP, Lunemann JD, Wengert O, et al. TNF-related apoptosis inducing ligand (TRAIL) as a potential response marker for interferon-beta treatment in multiple sclerosis. Lancet 2003;361:2036-2043
-
(2003)
Lancet
, vol.361
, pp. 2036-2043
-
-
Wandinger, K.P.1
Lunemann, J.D.2
Wengert, O.3
-
30
-
-
10344260656
-
TRAIL-R as a negative regulator of innate immune cell responses
-
Diehl GE, Yue HH, Hsieh K, et al. TRAIL-R as a negative regulator of innate immune cell responses. Immunity 2004;21:877-889
-
(2004)
Immunity
, vol.21
, pp. 877-889
-
-
Diehl, G.E.1
Yue, H.H.2
Hsieh, K.3
-
31
-
-
3543035176
-
Rare loss-of-function mutation of a death receptor gene in head and neck cancer
-
Pai SI, Wu GS, Ozoren N, et al. Rare loss-of-function mutation of a death receptor gene in head and neck cancer. Cancer Res 1998;58:3513-3518
-
(1998)
Cancer Res
, vol.58
, pp. 3513-3518
-
-
Pai, S.I.1
Wu, G.S.2
Ozoren, N.3
-
32
-
-
4644245083
-
Inducible silencing of KILLER/DR5 in vivo promotes bioluminescent colon tumor xenograft growth and confers resistance to chemotherapeutic agent 5-fluorouracil
-
Wang S, El-Deiry WS. Inducible silencing of KILLER/DR5 in vivo promotes bioluminescent colon tumor xenograft growth and confers resistance to chemotherapeutic agent 5-fluorouracil. Cancer Res 2004;64(18):6666-6672
-
(2004)
Cancer Res
, vol.64
, Issue.18
, pp. 6666-6672
-
-
Wang, S.1
El-Deiry, W.S.2
-
33
-
-
38149139518
-
TRAIL-R deficiency in mice promotes susceptibility to chronic inflammation and tumorigenesis
-
Finnberg N, Klein-Szanto AJ, El-Deiry WS. TRAIL-R deficiency in mice promotes susceptibility to chronic inflammation and tumorigenesis. J Clin Invest 2008;118:111-123
-
(2008)
J Clin Invest
, vol.118
, pp. 111-123
-
-
Finnberg, N.1
Klein-Szanto, A.J.2
El-Deiry, W.S.3
-
34
-
-
20044391426
-
DR5 knockout mice are compromised in radiation-induced apoptosis
-
Finnberg N, Gruber JJ, Fei P, et al. DR5 knockout mice are compromised in radiation-induced apoptosis. Mol Cell Biol 2005;25:2000-2013
-
(2005)
Mol Cell Biol
, vol.25
, pp. 2000-2013
-
-
Finnberg, N.1
Gruber, J.J.2
Fei, P.3
-
35
-
-
38849113981
-
DR5 receptor mediates anoikis in human colorectal carcinoma cell lines
-
Laguinge LM, Samara RN, Wang W, et al. DR5 receptor mediates anoikis in human colorectal carcinoma cell lines. Cancer Res 2008;68:909-917
-
(2008)
Cancer Res
, vol.68
, pp. 909-917
-
-
Laguinge, L.M.1
Samara, R.N.2
Wang, W.3
-
36
-
-
54249107246
-
The promise of cancer therapeutics targeting the TNF-related apoptosis-inducing ligand and TRAIL receptor pathway
-
Wang S. The promise of cancer therapeutics targeting the TNF-related apoptosis-inducing ligand and TRAIL receptor pathway. Oncogene 2008;27:6207-6215
-
(2008)
Oncogene
, vol.27
, pp. 6207-6215
-
-
Wang, S.1
-
37
-
-
38149122326
-
TRAIL-R deficiency in mice enhances lymph node metastasis without affecting primary tumor development
-
Grosse-Wilde A, Voloshanenko O, Bailey SL, et al. TRAIL-R deficiency in mice enhances lymph node metastasis without affecting primary tumor development. J Clin Invest 2008;118:100-110
-
(2008)
J Clin Invest
, vol.118
, pp. 100-110
-
-
Grosse-Wilde, A.1
Voloshanenko, O.2
Bailey, S.L.3
-
38
-
-
0032929520
-
Tumoricidal activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo
-
Walczak H, Miller RE, Ariail K, et al. Tumoricidal activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo. Nat Med 1999;5:157-163
-
(1999)
Nat Med
, vol.5
, pp. 157-163
-
-
Walczak, H.1
Miller, R.E.2
Ariail, K.3
-
39
-
-
2942692083
-
Differential induction of apoptosis by tumor necrosis factor-related apoptosis-inducing ligand in human ovarian carcinoma cells
-
Lane D, Cartier A, LEsperance S, et al. Differential induction of apoptosis by tumor necrosis factor-related apoptosis-inducing ligand in human ovarian carcinoma cells. Gynecol Oncol 2004;93:594-604
-
(2004)
Gynecol Oncol
, vol.93
, pp. 594-604
-
-
Lane, D.1
Cartier, A.2
Lesperance, S.3
-
40
-
-
33749002876
-
Inducible resistance of tumor cells to tumor necrosis factor-related apoptosis-inducing ligand receptor 2-mediated apoptosis by generation of a blockade at the death domain function
-
Li Y, Wang H, Wang Z, et al. Inducible resistance of tumor cells to tumor necrosis factor-related apoptosis-inducing ligand receptor 2-mediated apoptosis by generation of a blockade at the death domain function. Cancer Res 2006;66:8520-8528
-
(2006)
Cancer Res
, vol.66
, pp. 8520-8528
-
-
Li, Y.1
Wang, H.2
Wang, Z.3
-
41
-
-
42749093490
-
MicroRNA signatures of TRAIL resistance in human non-small cell lung cancer
-
Garofalo M, Quintavalle C, Di Leva G, et al. MicroRNA signatures of TRAIL resistance in human non-small cell lung cancer. Oncogene 2008;27:3845-3855
-
(2008)
Oncogene
, vol.27
, pp. 3845-3855
-
-
Garofalo, M.1
Quintavalle, C.2
Di Leva, G.3
-
42
-
-
70949104622
-
MiR-221&222 regulate TRAIL resistance and enhance tumorigenicity through PTEN and TIMP3 downregulation
-
Garofalo M, Di Leva G, Romano G, et al. miR-221&222 regulate TRAIL resistance and enhance tumorigenicity through PTEN and TIMP3 downregulation. Cancer Cell 2009;16:498-509
-
(2009)
Cancer Cell
, vol.16
, pp. 498-509
-
-
Garofalo, M.1
Di Leva, G.2
Romano, G.3
-
43
-
-
0034662625
-
Loss of caspase-8 expression in highly malignant human neuroblastoma cells correlates with resistance to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis
-
Hopkins-Donaldson S, Bodmer JL, Bourloud KB, et al. Loss of caspase-8 expression in highly malignant human neuroblastoma cells correlates with resistance to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis. Cancer Res 2000;60:4315-4319
-
(2000)
Cancer Res
, vol.60
, pp. 4315-4319
-
-
Hopkins-Donaldson, S.1
Bodmer, J.L.2
Bourloud, K.B.3
-
44
-
-
29244477848
-
Inhibition of DNA methylation sensitizes glioblastoma for tumor necrosis factor-related apoptosis-inducing ligand-mediated destruction
-
Eramo A, Pallini R, Lotti F, et al. Inhibition of DNA methylation sensitizes glioblastoma for tumor necrosis factor-related apoptosis-inducing ligand-mediated destruction. Cancer Res 2005;65:11469-11477
-
(2005)
Cancer Res
, vol.65
, pp. 11469-11477
-
-
Eramo, A.1
Pallini, R.2
Lotti, F.3
-
45
-
-
2342615480
-
X-linked inhibitor of apoptosis protein (XIAP) is a nonredundant modulator of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis in human cancer cells
-
Cummins JM, Kohli M, Rago C, et al. X-linked inhibitor of apoptosis protein (XIAP) is a nonredundant modulator of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis in human cancer cells. Cancer Res 2004;64:3006-3008
-
(2004)
Cancer Res
, vol.64
, pp. 3006-3008
-
-
Cummins, J.M.1
Kohli, M.2
Rago, C.3
-
46
-
-
34347246278
-
Reduction of TRAIL-induced Mcl-1 and cIAP2 by c-Myc or sorafenib sensitizes resistant human cancer cells to TRAIL-induced death
-
Ricci MS, Kim SH, Ogi K, et al. Reduction of TRAIL-induced Mcl-1 and cIAP2 by c-Myc or sorafenib sensitizes resistant human cancer cells to TRAIL-induced death. Cancer Cell 2007;12:66-80
-
(2007)
Cancer Cell
, vol.12
, pp. 66-80
-
-
Ricci, M.S.1
Kim, S.H.2
Ogi, K.3
-
47
-
-
0036341291
-
Smac agonists sensitize for Apo2L/TRAIL- or anticancer drug-induced apoptosis and induce regression of malignant glioma in vivo
-
Fulda S, Wick W, Weller M, Debatin KM. Smac agonists sensitize for Apo2L/TRAIL- or anticancer drug-induced apoptosis and induce regression of malignant glioma in vivo. Nat Med 2002;8:808-815
-
(2002)
Nat Med
, vol.8
, pp. 808-815
-
-
Fulda, S.1
Wick, W.2
Weller, M.3
Debatin, K.M.4
-
48
-
-
0037067678
-
Tumor necrosis factor-related apoptosis-inducing ligand-induced death-inducing signaling complex and its modulation by c-FLIP and PED/PEA-15 in glioma cells
-
Xiao C, Yang BF, Asadi N, et al. Tumor necrosis factor-related apoptosis-inducing ligand-induced death-inducing signaling complex and its modulation by c-FLIP and PED/PEA-15 in glioma cells. J Biol Chem 2002;277:25020-25025
-
(2002)
J Biol Chem
, vol.277
, pp. 25020-25025
-
-
Xiao, C.1
Yang, B.F.2
Asadi, N.3
-
49
-
-
0037672290
-
Expression of TRAIL (TNF-related apoptosis-inducing ligand) and its receptors in normal colonic mucosa, adenomas, and carcinomas
-
Koornstra JJ, Kleibeuker JH, van Geelen CM, et al. Expression of TRAIL (TNF-related apoptosis-inducing ligand) and its receptors in normal colonic mucosa, adenomas, and carcinomas. J Pathol 2003;200:327-335
-
(2003)
J Pathol
, vol.200
, pp. 327-335
-
-
Koornstra, J.J.1
Kleibeuker, J.H.2
Van Geelen, C.M.3
-
50
-
-
4544253226
-
Direct repression of FLIP expression by c-myc is a major determinant of TRAIL sensitivity
-
Ricci MS, Jin Z, Dews M, et al. Direct repression of FLIP expression by c-myc is a major determinant of TRAIL sensitivity. Mol Cell Biol 2004;24:8541-8555
-
(2004)
Mol Cell Biol
, vol.24
, pp. 8541-8555
-
-
Ricci, M.S.1
Jin, Z.2
Dews, M.3
-
51
-
-
18744425429
-
The caspase-8 inhibitor FLIP promotes activation of NF-kappaB and Erk signaling pathways
-
Kataoka T, Budd RC, Holler N, et al. The caspase-8 inhibitor FLIP promotes activation of NF-kappaB and Erk signaling pathways. Curr Biol 2000;10:640-648
-
(2000)
Curr Biol
, vol.10
, pp. 640-648
-
-
Kataoka, T.1
Budd, R.C.2
Holler, N.3
-
52
-
-
33749164762
-
Differential inhibition of TRAIL-mediated DR5-DISC formation by decoy receptors 1 and 2
-
Merino D, Lalaoui N, Morizot A, et al. Differential inhibition of TRAIL-mediated DR5-DISC formation by decoy receptors 1 and 2. Mol Cell Biol 2006;26:7046-7055
-
(2006)
Mol Cell Biol
, vol.26
, pp. 7046-7055
-
-
Merino, D.1
Lalaoui, N.2
Morizot, A.3
-
53
-
-
21344474349
-
Contribution of epigenetic silencing of tumor necrosis factor-related apoptosis inducing ligand receptor 1 (DR4) to TRAIL resistance and ovarian cancer
-
Horak P, Pils D, Haller G, et al. Contribution of epigenetic silencing of tumor necrosis factor-related apoptosis inducing ligand receptor 1 (DR4) to TRAIL resistance and ovarian cancer. Mol Cancer Res 2005;3:335-343
-
(2005)
Mol Cancer Res
, vol.3
, pp. 335-343
-
-
Horak, P.1
Pils, D.2
Haller, G.3
-
54
-
-
0034901512
-
Nucleotide substitution in the ectodomain of trail receptor DR4 is associated with lung cancer and head and neck cancer
-
Fisher MJ, Virmani AK, Wu L, et al. Nucleotide substitution in the ectodomain of trail receptor DR4 is associated with lung cancer and head and neck cancer. Clin Cancer Res 2001;7:1688-1697
-
(2001)
Clin Cancer Res
, vol.7
, pp. 1688-1697
-
-
Fisher, M.J.1
Virmani, A.K.2
Wu, L.3
-
55
-
-
34948822418
-
Tumor-derived mutations in the TRAIL receptor DR5 inhibit TRAIL signaling through the DR4 receptor by competing for ligand binding
-
Bin L, Thorburn J, Thomas LR, et al. Tumor-derived mutations in the TRAIL receptor DR5 inhibit TRAIL signaling through the DR4 receptor by competing for ligand binding. J Biol Chem 2007;282:28189-28194
-
(2007)
J Biol Chem
, vol.282
, pp. 28189-28194
-
-
Bin, L.1
Thorburn, J.2
Thomas, L.R.3
-
56
-
-
29244483111
-
TRAIL receptor-selective mutants signal to apoptosis via TRAIL-R1 in primary lymphoid malignancies
-
MacFarlane M, Kohlhaas SL, Sutcliffe MJ, et al. TRAIL receptor-selective mutants signal to apoptosis via TRAIL-R1 in primary lymphoid malignancies. Cancer Res 2005;65:11265-11270
-
(2005)
Cancer Res
, vol.65
, pp. 11265-11270
-
-
MacFarlane, M.1
Kohlhaas, S.L.2
Sutcliffe, M.J.3
-
57
-
-
34948894931
-
Death-receptor O-glycosylation controls tumor-cell sensitivity to the proapoptotic ligand Apo2L/TRAIL
-
Wagner KW, Punnoose EA, Januario T, et al. Death-receptor O-glycosylation controls tumor-cell sensitivity to the proapoptotic ligand Apo2L/TRAIL. Nat Med 2007;13:1070-1077
-
(2007)
Nat Med
, vol.13
, pp. 1070-1077
-
-
Wagner, K.W.1
Punnoose, E.A.2
Januario, T.3
-
58
-
-
34047258345
-
Sensitization of mesothelioma cells to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by heat stress via the inhibition of the 3-phosphoinositide-dependent kinase 1/Akt pathway
-
Pespeni MH, Hodnett M, Abayasiriwardana KS, et al. Sensitization of mesothelioma cells to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by heat stress via the inhibition of the 3-phosphoinositide-dependent kinase 1/Akt pathway. Cancer Res 2007;67:2865-2871
-
(2007)
Cancer Res
, vol.67
, pp. 2865-2871
-
-
Pespeni, M.H.1
Hodnett, M.2
Abayasiriwardana, K.S.3
-
59
-
-
0038414629
-
TRAIL promotes the survival and proliferation of primary human vascular endothelial cells by activating the Akt and ERK pathways
-
Secchiero P, Gonelli A, Carnevale E, et al. TRAIL promotes the survival and proliferation of primary human vascular endothelial cells by activating the Akt and ERK pathways. Circulation 2003;107:2250-2256
-
(2003)
Circulation
, vol.107
, pp. 2250-2256
-
-
Secchiero, P.1
Gonelli, A.2
Carnevale, E.3
-
60
-
-
34248162523
-
Six1 overexpression in ovarian carcinoma causes resistance to TRAIL-mediated apoptosis and is associated with poor survival
-
Behbakht K, Qamar L, Aldridge CS, et al. Six1 overexpression in ovarian carcinoma causes resistance to TRAIL-mediated apoptosis and is associated with poor survival. Cancer Res 2007;67:3036-3042
-
(2007)
Cancer Res
, vol.67
, pp. 3036-3042
-
-
Behbakht, K.1
Qamar, L.2
Aldridge, C.S.3
-
61
-
-
16844372087
-
Gene amplification is a mechanism of Six1 overexpression in breast cancer
-
Reichenberger KJ, Coletta RD, Schulte AP, et al. Gene amplification is a mechanism of Six1 overexpression in breast cancer. Cancer Res 2005;65:2668-2675
-
(2005)
Cancer Res
, vol.65
, pp. 2668-2675
-
-
Reichenberger, K.J.1
Coletta, R.D.2
Schulte, A.P.3
-
62
-
-
77956342464
-
MicroRNA-185 suppresses tumor growth and progression by targeting the Six1 oncogene in human cancers
-
published online 5 July 2010, doi: 10.1038/onc.2010.233
-
Imam JS, Buddavarapu K, Lee-Chang JS, et al. MicroRNA-185 suppresses tumor growth and progression by targeting the Six1 oncogene in human cancers. Oncogene 2010: published online 5 July 2010, doi: 10.1038/onc.2010.233
-
(2010)
Oncogene
-
-
Imam, J.S.1
Buddavarapu, K.2
Lee-Chang, J.S.3
-
63
-
-
0032575714
-
Death receptors: Signaling and modulation
-
Ashkenazi A, Dixit VM. Death receptors: signaling and modulation. Science 1998;281:1305-1308
-
(1998)
Science
, vol.281
, pp. 1305-1308
-
-
Ashkenazi, A.1
Dixit, V.M.2
-
64
-
-
17544367410
-
Induction of apoptosis by Apo-2 ligand, a new member of the tumor necrosis factor cytokine family
-
DOI 10.1074/jbc.271.22.12687
-
Pitti RM, Marsters SA, Ruppert S, et al. Induction of apoptosis by Apo-2 ligand, a new member of the tumor necrosis factor cytokine family. J Biol Chem 1996;271:12687-12690 (Pubitemid 26175834)
-
(1996)
Journal of Biological Chemistry
, vol.271
, Issue.22
, pp. 12687-12690
-
-
Pitti, R.M.1
Marsters, S.A.2
Ruppert, S.3
Donahue, C.J.4
Moore, A.5
Ashkenazi, A.6
-
65
-
-
0033911632
-
Production of recombinant TRAIL and TRAIL receptor: Fc chimeric proteins
-
Schneider P. Production of recombinant TRAIL and TRAIL receptor: Fc chimeric proteins. Methods Enzymol 2000;322:325-345
-
(2000)
Methods Enzymol
, vol.322
, pp. 325-345
-
-
Schneider, P.1
-
66
-
-
33646393778
-
Preclinical differentiation between apparently safe and potentially hepatotoxic applications of TRAIL either alone or in combination with chemotherapeutic drugs
-
Ganten TM, Koschny R, Sykora J, et al. Preclinical differentiation between apparently safe and potentially hepatotoxic applications of TRAIL either alone or in combination with chemotherapeutic drugs. Clin Cancer Res 2006;12:2640-2646
-
(2006)
Clin Cancer Res
, vol.12
, pp. 2640-2646
-
-
Ganten, T.M.1
Koschny, R.2
Sykora, J.3
-
67
-
-
0034855468
-
Suppression of tumor growth following intralesional therapy with TRAIL recombinant adenovirus
-
Griffith TS, Broghammer EL. Suppression of tumor growth following intralesional therapy with TRAIL recombinant adenovirus. Mol Ther 2001;4:257-266
-
(2001)
Mol Ther
, vol.4
, pp. 257-266
-
-
Griffith, T.S.1
Broghammer, E.L.2
-
68
-
-
0033135221
-
In situ gene therapy for adenocarcinoma of the prostate: A Phase i clinical trial
-
Herman JR, Adler HL, Aguilar-Cordova E, et al. In situ gene therapy for adenocarcinoma of the prostate: a Phase I clinical trial. Hum Gene Ther 1999;10:1239-1249
-
(1999)
Hum Gene Ther
, vol.10
, pp. 1239-1249
-
-
Herman, J.R.1
Adler, H.L.2
Aguilar-Cordova, E.3
-
70
-
-
3342894130
-
Targeting death receptors in cancer with Apo2L/TRAIL
-
Kelley SK, Ashkenazi A. Targeting death receptors in cancer with Apo2L/TRAIL. Curr Opin Pharmacol 2004;4:333-339
-
(2004)
Curr Opin Pharmacol
, vol.4
, pp. 333-339
-
-
Kelley, S.K.1
Ashkenazi, A.2
-
71
-
-
0034022160
-
Apoptosis induced in normal human hepatocytes by tumor necrosis factor-related apoptosis-inducing ligand
-
Jo M, Kim TH, Seol DW, et al. Apoptosis induced in normal human hepatocytes by tumor necrosis factor-related apoptosis-inducing ligand. Nat Med 2000;6:564-567
-
(2000)
Nat Med
, vol.6
, pp. 564-567
-
-
Jo, M.1
Kim, T.H.2
Seol, D.W.3
-
72
-
-
0035050960
-
Differential hepatocyte toxicity of recombinant Apo2L/TRAIL versions
-
Lawrence D, Shahrokh Z, Marsters S, et al. Differential hepatocyte toxicity of recombinant Apo2L/TRAIL versions. Nat Med 2001;7:383-385
-
(2001)
Nat Med
, vol.7
, pp. 383-385
-
-
Lawrence, D.1
Shahrokh, Z.2
Marsters, S.3
-
73
-
-
0742272016
-
Human normal hepatocytes are susceptible to apoptosis signal mediated by both TRAIL-R1 and TRAIL-R2
-
Mori E, Thomas M, Motoki K, et al. Human normal hepatocytes are susceptible to apoptosis signal mediated by both TRAIL-R1 and TRAIL-R2. Cell Death Differ 2004;11:203-207
-
(2004)
Cell Death Differ
, vol.11
, pp. 203-207
-
-
Mori, E.1
Thomas, M.2
Motoki, K.3
-
75
-
-
49449097533
-
Death receptor 5 mediated-apoptosis contributes to cholestatic liver disease
-
Takeda K, Kojima Y, Ikejima K, et al. Death receptor 5 mediated-apoptosis contributes to cholestatic liver disease. Proc Natl Acad Sci USA 2008;105:10895-10900
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 10895-10900
-
-
Takeda, K.1
Kojima, Y.2
Ikejima, K.3
-
76
-
-
35948952826
-
Phase 1 and pharmacokinetic study of lexatumumab in patients with advanced cancers
-
Plummer R, Attard G, Pacey S, et al. Phase 1 and pharmacokinetic study of lexatumumab in patients with advanced cancers. Clin Cancer Res 2007;13:6187-6194
-
(2007)
Clin Cancer Res
, vol.13
, pp. 6187-6194
-
-
Plummer, R.1
Attard, G.2
Pacey, S.3
-
77
-
-
36348941705
-
Increased hepatotoxicity of tumor necrosis factor-related apoptosis-inducing ligand in diseased human liver
-
Volkmann X, Fischer U, Bahr MJ, et al. Increased hepatotoxicity of tumor necrosis factor-related apoptosis-inducing ligand in diseased human liver. Hepatology 2007;46:1498-1508
-
(2007)
Hepatology
, vol.46
, pp. 1498-1508
-
-
Volkmann, X.1
Fischer, U.2
Bahr, M.J.3
-
78
-
-
0033721127
-
The caspase 9 inhibitor Z-LEHD-FMK protects human liver cells while permitting death of cancer cells exposed to tumor necrosis factor-related apoptosis-inducing ligand
-
Ozoren N, Kim K, Burns TF, et al. The caspase 9 inhibitor Z-LEHD-FMK protects human liver cells while permitting death of cancer cells exposed to tumor necrosis factor-related apoptosis-inducing ligand. Cancer Res 2000;60:6259-6265
-
(2000)
Cancer Res
, vol.60
, pp. 6259-6265
-
-
Ozoren, N.1
Kim, K.2
Burns, T.F.3
-
79
-
-
58149456883
-
Death receptors as targets for anti-cancer therapy
-
Papenfuss K, Cordier SM, Walczak H. Death receptors as targets for anti-cancer therapy. J Cell Mol Med 2008;12:2566-2585
-
(2008)
J Cell Mol Med
, vol.12
, pp. 2566-2585
-
-
Papenfuss, K.1
Cordier, S.M.2
Walczak, H.3
-
80
-
-
34248187996
-
Phase i pharmacokinetic and biologic correlative study of mapatumumab, a fully human monoclonal antibody with agonist activity to tumor necrosis factor-related apoptosis-inducing ligand receptor-1
-
Tolcher AW, Mita M, Meropol NJ, et al. Phase I pharmacokinetic and biologic correlative study of mapatumumab, a fully human monoclonal antibody with agonist activity to tumor necrosis factor-related apoptosis-inducing ligand receptor-1. J Clin Oncol 2007;25:1390-1395
-
(2007)
J Clin Oncol
, vol.25
, pp. 1390-1395
-
-
Tolcher, A.W.1
Mita, M.2
Meropol, N.J.3
-
81
-
-
72449141229
-
Phase i and pharmacokinetic study of lexatumumab (HGS-ETR2) given every 2 weeks in patients with advanced solid tumors
-
Wakelee HA, Patnaik A, Sikic BI, et al. Phase I and pharmacokinetic study of lexatumumab (HGS-ETR2) given every 2 weeks in patients with advanced solid tumors. Ann Oncol 2010;21:376-381
-
(2010)
Ann Oncol
, vol.21
, pp. 376-381
-
-
Wakelee, H.A.1
Patnaik, A.2
Sikic, B.I.3
-
82
-
-
33747829837
-
Combined treatment of colorectal tumours with agonistic TRAIL receptor antibodies HGS-ETR1 and HGS-ETR2 and radiotherapy: Enhanced effects in vitro and dose-dependent growth delay in vivo
-
Marini P, Denzinger S, Schiller D, et al. Combined treatment of colorectal tumours with agonistic TRAIL receptor antibodies HGS-ETR1 and HGS-ETR2 and radiotherapy: enhanced effects in vitro and dose-dependent growth delay in vivo. Oncogene 2006;25:5145-5154
-
(2006)
Oncogene
, vol.25
, pp. 5145-5154
-
-
Marini, P.1
Denzinger, S.2
Schiller, D.3
-
83
-
-
35748975398
-
TRAIL signals to apoptosis in chronic lymphocytic leukaemia cells primarily through TRAIL-R1 whereas cross-linked agonistic TRAIL-R2 antibodies facilitate signalling via TRAIL-R2
-
Natoni A, MacFarlane M, Inoue S, et al. TRAIL signals to apoptosis in chronic lymphocytic leukaemia cells primarily through TRAIL-R1 whereas cross-linked agonistic TRAIL-R2 antibodies facilitate signalling via TRAIL-R2. Br J Haematol 2007;139:568-577
-
(2007)
Br J Haematol
, vol.139
, pp. 568-577
-
-
Natoni, A.1
MacFarlane, M.2
Inoue, S.3
-
84
-
-
45649084324
-
Phase 2 study of mapatumumab, a fully human agonistic monoclonal antibody which targets and activates the TRAIL receptor-1, in patients with advanced non-small cell lung cancer
-
Greco FA, Bonomi P, Crawford J, et al. Phase 2 study of mapatumumab, a fully human agonistic monoclonal antibody which targets and activates the TRAIL receptor-1, in patients with advanced non-small cell lung cancer. Lung Cancer 2008;61:82-90
-
(2008)
Lung Cancer
, vol.61
, pp. 82-90
-
-
Greco, F.A.1
Bonomi, P.2
Crawford, J.3
-
85
-
-
76349085626
-
Phase II trial of mapatumumab, a fully human agonistic monoclonal antibody that targets and activates the tumour necrosis factor apoptosis-inducing ligand receptor-1 (TRAIL-R1), in patients with refractory colorectal cancer
-
Trarbach T, Moehler M, Heinemann V, et al. Phase II trial of mapatumumab, a fully human agonistic monoclonal antibody that targets and activates the tumour necrosis factor apoptosis-inducing ligand receptor-1 (TRAIL-R1), in patients with refractory colorectal cancer. Br J Cancer 2010;102:506-512
-
(2010)
Br J Cancer
, vol.102
, pp. 506-512
-
-
Trarbach, T.1
Moehler, M.2
Heinemann, V.3
-
86
-
-
69949110775
-
Mapatumumab, a fully human agonistic monoclonal antibody that targets TRAIL-R1, in combination with gemcitabine and cisplatin: A Phase i study
-
Mom CH, Verweij J, Oldenhuis CN, et al. Mapatumumab, a fully human agonistic monoclonal antibody that targets TRAIL-R1, in combination with gemcitabine and cisplatin: a Phase I study. Clin Cancer Res 2009;15:5584-5590
-
(2009)
Clin Cancer Res
, vol.15
, pp. 5584-5590
-
-
Mom, C.H.1
Verweij, J.2
Oldenhuis, C.N.3
-
87
-
-
70349318434
-
Mapatumumab, an antibody targeting TRAIL-R1, in combination with paclitaxel and carboplatin in patients with advanced solid malignancies: Results of a Phase i and pharmacokinetic study
-
Leong S, Cohen RB, Gustafson DL, et al. Mapatumumab, an antibody targeting TRAIL-R1, in combination with paclitaxel and carboplatin in patients with advanced solid malignancies: results of a Phase I and pharmacokinetic study. J Clin Oncol 2009;27:4413-4421
-
(2009)
J Clin Oncol
, vol.27
, pp. 4413-4421
-
-
Leong, S.1
Cohen, R.B.2
Gustafson, D.L.3
-
88
-
-
77957066380
-
Sorafenib sensitizes hepatocellular carcinoma cells to TRAIL or TRAIL receptor agonist antibodies [abstract #833]
-
12 - 16 April; San Diego, CA
-
Abdulghani J, Mayes P, Dicker D, et al. Sorafenib sensitizes hepatocellular carcinoma cells to TRAIL or TRAIL receptor agonist antibodies [abstract #833]. 99th AACR Annual Meeting; 12 - 16 April 2008; San Diego, CA
-
(2008)
99th AACR Annual Meeting
-
-
Abdulghani, J.1
Mayes, P.2
Dicker, D.3
-
89
-
-
45749137688
-
A phase Ib study to assess the safety of lexatumumab, a human monoclonal antibody that activates TRAIL-R2, in combination with gemcitabine, pemetrexed, doxorubicin or FOLFIRI. 2007 ASCO Annual Meeting Proceedings Part I
-
[abstract 14006]
-
Sikic BI, Wakelee HA, von Mehren M, Lewis N. A phase Ib study to assess the safety of lexatumumab, a human monoclonal antibody that activates TRAIL-R2, in combination with gemcitabine, pemetrexed, doxorubicin or FOLFIRI. 2007 ASCO Annual Meeting Proceedings Part I. J Clin Oncol 2007;25:18S [abstract 14006]
-
(2007)
J Clin Oncol
, vol.25
-
-
Sikic, B.I.1
Wakelee, H.A.2
Von Mehren, M.3
Lewis, N.4
-
90
-
-
77957047301
-
In vivo tumor regression achieved by a potent bivalent Smac mimetic (SM-164) in combination with TRAIL [abstract C228]
-
22 - 26 October; San Francisco, CA
-
Lu J, Sun H, McEachern D, et al. In vivo tumor regression achieved by a potent bivalent Smac mimetic (SM-164) in combination with TRAIL [abstract C228]. AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics; 22 - 26 October 2007; San Francisco, CA
-
(2007)
AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics
-
-
Lu, J.1
Sun, H.2
McEachern, D.3
-
91
-
-
0141679399
-
Antitumor efficacy of TRA-8 anti-DR5 monoclonal antibody alone or in combination with chemotherapy and/or radiation therapy in a human breast cancer model
-
Buchsbaum DJ, Zhou T, Grizzle WE, et al. Antitumor efficacy of TRA-8 anti-DR5 monoclonal antibody alone or in combination with chemotherapy and/or radiation therapy in a human breast cancer model. Clin Cancer Res 2003;9:3731-3741
-
(2003)
Clin Cancer Res
, vol.9
, pp. 3731-3741
-
-
Buchsbaum, D.J.1
Zhou, T.2
Grizzle, W.E.3
-
92
-
-
17944376030
-
Tumoricidal activity of a novel anti-human DR5 monoclonal antibody without hepatocyte cytotoxicity
-
Ichikawa K, Liu W, Zhao L, et al. Tumoricidal activity of a novel anti-human DR5 monoclonal antibody without hepatocyte cytotoxicity. Nat Med 2001;7:954-960
-
(2001)
Nat Med
, vol.7
, pp. 954-960
-
-
Ichikawa, K.1
Liu, W.2
Zhao, L.3
-
93
-
-
55949100658
-
A phase i study of CS-1008 (humanized monoclonal antibody targeting death receptor 5 or DR5), administered weekly to patients with advanced solid tumors or lymphomas
-
abstract 3537
-
Saleh MN, Percent I, Wood TE, et al. A phase I study of CS-1008 (humanized monoclonal antibody targeting death receptor 5 or DR5), administered weekly to patients with advanced solid tumors or lymphomas. 2008 ASCO Annual Meeting, J Clin Oncol 2008;26(20 Suppl):abstract 3537
-
(2008)
2008 ASCO Annual Meeting, J Clin Oncol
, vol.26
, Issue.20 SUPPL.
-
-
Saleh, M.N.1
Percent, I.2
Wood, T.E.3
-
94
-
-
47149095569
-
LBY135, a novel anti-DR5 agonistic antibody induces tumor cell-specific cytotoxic activity in human colon tumor cell lines and xenografts
-
Li J, Knee DA, Wang Y, Zhang Q. LBY135, a novel anti-DR5 agonistic antibody induces tumor cell-specific cytotoxic activity in human colon tumor cell lines and xenografts. Drug Dev Res 2008;69:69-82
-
(2008)
Drug Dev Res
, vol.69
, pp. 69-82
-
-
Li, J.1
Knee, D.A.2
Wang, Y.3
Zhang, Q.4
-
95
-
-
55949100931
-
Phase i trial of LBY135, a monoclonal antibody agonist to DR5, alone and in combination with capecitabine in advanced solid tumors
-
ASCO Annual Meeting Proceedings
-
Sharma S, de Vries EG, Infante JR, Oldenhuis C. Phase I trial of LBY135, a monoclonal antibody agonist to DR5, alone and in combination with capecitabine in advanced solid tumors. 2008 ASCO Annual Meeting Proceedings. J Clin Oncol 2008;26(15S):3538
-
(2008)
J Clin Oncol
, vol.26
, Issue.15
, pp. 3538
-
-
Sharma, S.1
De Vries, E.G.2
Infante, J.R.3
Oldenhuis, C.4
-
96
-
-
44749091927
-
A phase i safety and pharmacokinetic study of apomab, a human DR5 agonist antibody, in patients with advanced cancer. 2007 ASCO Annual Meeting Proceedings (Post-Meeting Edition)
-
Camidge D, Herbst RS, Gordon M, et al. A phase I safety and pharmacokinetic study of apomab, a human DR5 agonist antibody, in patients with advanced cancer. 2007 ASCO Annual Meeting Proceedings (Post-Meeting Edition). J Clin Oncol 2007;25(18S):3582
-
(2007)
J Clin Oncol
, vol.25
, Issue.18
, pp. 3582
-
-
Camidge, D.1
Herbst, R.S.2
Gordon, M.3
-
97
-
-
52649109068
-
The TRAIL apoptotic pathway in cancer onset, progression and therapy
-
Genentech BioOncology Pipeline Fact Sheet, Pipeline: Insight and Innovation from Genentech BioOncology South San Francisco, CA, USA: Genentech Available from [Last accessed 30 August 2010]
-
Johnstone RW, Frew AJ, Smyth MJ. The TRAIL apoptotic pathway in cancer onset, progression and therapy. Nat Rev Cancer 2008;8:782-798
-
(2008)
Nat Rev Cancer
, vol.8
, pp. 782-798
-
-
Johnstone, R.W.1
Frew, A.J.2
Smyth, M.J.3
-
98
-
-
45749105225
-
First-in-human study of AMG 655, a pro-apoptotic TRAIL receptor-2 agonist, in adult patients with advanced solid tumors. 2007 ASCO Annual Meeting Proceedings Part I
-
LoRusso P, Hong D, Heath E, et al. First-in-human study of AMG 655, a pro-apoptotic TRAIL receptor-2 agonist, in adult patients with advanced solid tumors. 2007 ASCO Annual Meeting Proceedings Part I. J Clin Oncol 2007;25(18S):3534
-
(2007)
J Clin Oncol
, vol.25
, Issue.18
, pp. 3534
-
-
Lorusso, P.1
Hong, D.2
Heath, E.3
-
99
-
-
37149035841
-
A phase IB safety and pharmacokinetic (PK) study of recombinant human Apo2L/TRAIL in combination with rituximab in patients with low-grade non-Hodgkin lymphoma. 2007 ASCO Annual Meeting Proceedings (Post-Meeting Edition)
-
Yee L, Fanale M, Dimick K, Calvert S. A phase IB safety and pharmacokinetic (PK) study of recombinant human Apo2L/TRAIL in combination with rituximab in patients with low-grade non-Hodgkin lymphoma. 2007 ASCO Annual Meeting Proceedings (Post-Meeting Edition). J Clin Oncol 2007;25(18S):8078
-
(2007)
J Clin Oncol
, vol.25
, Issue.18
, pp. 8078
-
-
Yee, L.1
Fanale, M.2
Dimick, K.3
Calvert, S.4
-
100
-
-
0035353207
-
Ionizing radiation sensitizes erythroleukemic cells but not normal erythroblasts to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) - mediated cytotoxicity by selective up-regulation of TRAIL-R1
-
Di Pietro R, Secchiero P, Rana R, et al. Ionizing radiation sensitizes erythroleukemic cells but not normal erythroblasts to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) - mediated cytotoxicity by selective up-regulation of TRAIL-R1. Blood 2001;97:2596-2603
-
(2001)
Blood
, vol.97
, pp. 2596-2603
-
-
Di Pietro, R.1
Secchiero, P.2
Rana, R.3
-
101
-
-
21744448694
-
Chronic lymphocytic leukemic cells exhibit apoptotic signaling via TRAIL-R1
-
MacFarlane M, Inoue S, Kohlhaas SL, et al. Chronic lymphocytic leukemic cells exhibit apoptotic signaling via TRAIL-R1. Cell Death Differ 2005;12:773-782
-
(2005)
Cell Death Differ
, vol.12
, pp. 773-782
-
-
MacFarlane, M.1
Inoue, S.2
Kohlhaas, S.L.3
-
102
-
-
4344666663
-
Histone deacetylase inhibitors upregulate death receptor 5/TRAIL-R2 and sensitize apoptosis induced by TRAIL/APO2-L in human malignant tumor cells
-
Nakata S, Yoshida T, Horinaka M, et al. Histone deacetylase inhibitors upregulate death receptor 5/TRAIL-R2 and sensitize apoptosis induced by TRAIL/APO2-L in human malignant tumor cells. Oncogene 2004;23:6261-6271
-
(2004)
Oncogene
, vol.23
, pp. 6261-6271
-
-
Nakata, S.1
Yoshida, T.2
Horinaka, M.3
-
103
-
-
21344453520
-
Proteasome inhibitor MG132 induces death receptor 5 through CCAAT/enhancer-binding protein homologous protein
-
Yoshida T, Shiraishi T, Nakata S, et al. Proteasome inhibitor MG132 induces death receptor 5 through CCAAT/enhancer-binding protein homologous protein. Cancer Res 2005;65:5662-5667
-
(2005)
Cancer Res
, vol.65
, pp. 5662-5667
-
-
Yoshida, T.1
Shiraishi, T.2
Nakata, S.3
-
104
-
-
1942436864
-
Proteasome inhibitor MG132 upregulates death receptor 5 and cooperates with Apo2L/TRAIL to induce apoptosis in Bax-proficient and -deficient cells
-
He Q, Huang Y, Sheikh MS. Proteasome inhibitor MG132 upregulates death receptor 5 and cooperates with Apo2L/TRAIL to induce apoptosis in Bax-proficient and -deficient cells. Oncogene 2004;23:2554-2558
-
(2004)
Oncogene
, vol.23
, pp. 2554-2558
-
-
He, Q.1
Huang, Y.2
Sheikh, M.S.3
-
105
-
-
34447294826
-
TRAIL therapy in non-small cell lung cancer cells: Sensitization to death receptor-mediated apoptosis by proteasome inhibitor bortezomib
-
Voortman J, Resende TP, Abou El Hassan MA, et al. TRAIL therapy in non-small cell lung cancer cells: sensitization to death receptor-mediated apoptosis by proteasome inhibitor bortezomib. Mol Cancer Ther 2007;6:2103-2112
-
(2007)
Mol Cancer Ther
, vol.6
, pp. 2103-2112
-
-
Voortman, J.1
Resende, T.P.2
Abou El Hassan, M.A.3
-
106
-
-
0034667482
-
Apo2 ligand/TNF-related apoptosis-inducing ligand and death receptor 5 mediate the apoptotic signaling induced by ionizing radiation in leukemic cells
-
Gong B, Almasan A. Apo2 ligand/TNF-related apoptosis-inducing ligand and death receptor 5 mediate the apoptotic signaling induced by ionizing radiation in leukemic cells. Cancer Res 2000;60:5754-5760
-
(2000)
Cancer Res
, vol.60
, pp. 5754-5760
-
-
Gong, B.1
Almasan, A.2
-
107
-
-
13144280868
-
Irradiation specifically sensitises solid tumour cell lines to TRAIL mediated apoptosis
-
Marini P, Schmid A, Jendrossek V, et al. Irradiation specifically sensitises solid tumour cell lines to TRAIL mediated apoptosis. BMC Cancer 2005;5:5
-
(2005)
BMC Cancer
, vol.5
, pp. 5
-
-
Marini, P.1
Schmid, A.2
Jendrossek, V.3
-
108
-
-
0036735391
-
Cyclooxygenase-2 overexpression inhibits death receptor 5 expression and confers resistance to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in human colon cancer cells
-
Tang X, Sun YJ, Half E, et al. Cyclooxygenase-2 overexpression inhibits death receptor 5 expression and confers resistance to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in human colon cancer cells. Cancer Res 2002;62:4903-4908
-
(2002)
Cancer Res
, vol.62
, pp. 4903-4908
-
-
Tang, X.1
Sun, Y.J.2
Half, E.3
-
109
-
-
10644257370
-
Death receptor regulation and celecoxib-induced apoptosis in human lung cancer cells
-
Liu X, Yue P, Zhou Z, et al. Death receptor regulation and celecoxib-induced apoptosis in human lung cancer cells. J Natl Cancer Inst 2004;96:1769-1780
-
(2004)
J Natl Cancer Inst
, vol.96
, pp. 1769-1780
-
-
Liu, X.1
Yue, P.2
Zhou, Z.3
-
110
-
-
0035884187
-
Sulindac sulfide-induced apoptosis involves death receptor 5 and the caspase 8-dependent pathway in human colon and prostate cancer cells
-
Huang Y, He Q, Hillman MJ, et al. Sulindac sulfide-induced apoptosis involves death receptor 5 and the caspase 8-dependent pathway in human colon and prostate cancer cells. Cancer Res 2001;61:6918-6924
-
(2001)
Cancer Res
, vol.61
, pp. 6918-6924
-
-
Huang, Y.1
He, Q.2
Hillman, M.J.3
-
111
-
-
33745810978
-
The TRAIL apoptotic pathway mediates proteasome inhibitor induced apoptosis in primary chronic lymphocytic leukemia cells
-
Kabore AF, Sun J, Hu X, et al. The TRAIL apoptotic pathway mediates proteasome inhibitor induced apoptosis in primary chronic lymphocytic leukemia cells. Apoptosis 2006;11:1175-1193
-
(2006)
Apoptosis
, vol.11
, pp. 1175-1193
-
-
Kabore, A.F.1
Sun, J.2
Hu, X.3
-
112
-
-
23244459828
-
Interactive effects of HDAC inhibitors and TRAIL on apoptosis are associated with changes in mitochondrial functions and expressions of cell cycle regulatory genes in multiple myeloma
-
Fandy TE, Shankar S, Ross DD, et al. Interactive effects of HDAC inhibitors and TRAIL on apoptosis are associated with changes in mitochondrial functions and expressions of cell cycle regulatory genes in multiple myeloma. Neoplasia 2005;7:646-657
-
(2005)
Neoplasia
, vol.7
, pp. 646-657
-
-
Fandy, T.E.1
Shankar, S.2
Ross, D.D.3
-
113
-
-
22744437647
-
HDAC inhibitors enhance the apoptosis-inducing potential of TRAIL in breast carcinoma
-
Singh TR, Shankar S, Srivastava RK. HDAC inhibitors enhance the apoptosis-inducing potential of TRAIL in breast carcinoma. Oncogene 2005;24:4609-4623
-
(2005)
Oncogene
, vol.24
, pp. 4609-4623
-
-
Singh, T.R.1
Shankar, S.2
Srivastava, R.K.3
-
114
-
-
27644543263
-
Sulindac sulfide-induced apoptosis is enhanced by a small-molecule Bcl-2 inhibitor and by TRAIL in human colon cancer cells overexpressing Bcl-2
-
Sinicrope FA, Penington RC. Sulindac sulfide-induced apoptosis is enhanced by a small-molecule Bcl-2 inhibitor and by TRAIL in human colon cancer cells overexpressing Bcl-2. Mol Cancer Ther 2005;4:1475-1483
-
(2005)
Mol Cancer Ther
, vol.4
, pp. 1475-1483
-
-
Sinicrope, F.A.1
Penington, R.C.2
-
115
-
-
0036605042
-
Chemotherapeutic agents sensitize osteogenic sarcoma cells, but not normal human bone cells, to Apo2L/TRAIL-induced apoptosis
-
Evdokiou A, Bouralexis S, Atkins GJ, et al. Chemotherapeutic agents sensitize osteogenic sarcoma cells, but not normal human bone cells, to Apo2L/TRAIL-induced apoptosis. Int J Cancer 2002;99:491-504
-
(2002)
Int J Cancer
, vol.99
, pp. 491-504
-
-
Evdokiou, A.1
Bouralexis, S.2
Atkins, G.J.3
-
116
-
-
0037457474
-
Enhancement of TRAIL/Apo2L-mediated apoptosis by adriamycin through inducing DR4 and DR5 in renal cell carcinoma cells
-
Wu XX, Kakehi Y, Mizutani Y, et al. Enhancement of TRAIL/Apo2L-mediated apoptosis by adriamycin through inducing DR4 and DR5 in renal cell carcinoma cells. Int J Cancer 2003;104:409-417
-
(2003)
Int J Cancer
, vol.104
, pp. 409-417
-
-
Wu, X.X.1
Kakehi, Y.2
Mizutani, Y.3
-
117
-
-
77957088784
-
Novel target of lapatinib enhances anti-tumor activity via TRAIL sensitization [abstract # 835]
-
12 - 16 April; San Diego, CA
-
Dolloff N, Mayes P, Dicker D, et al. Novel target of lapatinib enhances anti-tumor activity via TRAIL sensitization [abstract # 835]. 99th AACR Annual Meeting; 12 - 16 April 2008; San Diego, CA
-
(2008)
99th AACR Annual Meeting
-
-
Dolloff, N.1
Mayes, P.2
Dicker, D.3
|