메뉴 건너뛰기




Volumn 1766, Issue 1, 2006, Pages 53-62

Pro-apoptotic role of NF-κB: Implications for cancer therapy

Author keywords

Apoptosis; Cancer; Drug target; NF B

Indexed keywords

6 [3 (1 ADAMANTYL) 4 HYDROXYPHENYL] 2 NAPHTHOIC ACID; DAUNORUBICIN; DEATH RECEPTOR 5; DOXORUBICIN; DOXYCYCLINE; ETOPOSIDE; FAS ANTIGEN; FAS LIGAND; HISTONE DEACETYLASE 1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1; PROTEIN P100; RETINOID; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR REL; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND;

EID: 33746829168     PISSN: 0304419X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbcan.2006.02.001     Document Type: Review
Times cited : (103)

References (110)
  • 3
    • 9644268197 scopus 로고    scopus 로고
    • BCL-3 and NF-kappaB p50 attenuate lipopolysaccharide-induced inflammatory responses in macrophages
    • Wessells J., Baer M., Young H.A., Claudio E., Brown K., Siebenlist U., and Johnson P.F. BCL-3 and NF-kappaB p50 attenuate lipopolysaccharide-induced inflammatory responses in macrophages. J. Biol. Chem. 279 (2004) 49995-50003
    • (2004) J. Biol. Chem. , vol.279 , pp. 49995-50003
    • Wessells, J.1    Baer, M.2    Young, H.A.3    Claudio, E.4    Brown, K.5    Siebenlist, U.6    Johnson, P.F.7
  • 4
    • 14844293877 scopus 로고    scopus 로고
    • Positive and negative regulation of nuclear factor-kappaB-mediated transcription by IkappaB-zeta, an inducible nuclear protein
    • Motoyama M., Yamazaki S., Eto-Kimura A., Takeshige K., and Muta T. Positive and negative regulation of nuclear factor-kappaB-mediated transcription by IkappaB-zeta, an inducible nuclear protein. J. Biol. Chem. 280 (2005) 7444-7451
    • (2005) J. Biol. Chem. , vol.280 , pp. 7444-7451
    • Motoyama, M.1    Yamazaki, S.2    Eto-Kimura, A.3    Takeshige, K.4    Muta, T.5
  • 5
    • 0035500411 scopus 로고    scopus 로고
    • Phosphorylation by the protein kinase CK2 promotes calpain-mediated degradation of IkappaBalpha
    • Shen J., Channavajhala P., Seldin D.C., and Sonenshein G.E. Phosphorylation by the protein kinase CK2 promotes calpain-mediated degradation of IkappaBalpha. J. Immunol. 167 (2001) 4919-4925
    • (2001) J. Immunol. , vol.167 , pp. 4919-4925
    • Shen, J.1    Channavajhala, P.2    Seldin, D.C.3    Sonenshein, G.E.4
  • 6
    • 0242298578 scopus 로고    scopus 로고
    • CK2 is a C-terminal IkappaB kinase responsible for NF-kappaB activation during the UV response
    • Kato Jr. T., Delhase M., Hoffmann A., and Karin M. CK2 is a C-terminal IkappaB kinase responsible for NF-kappaB activation during the UV response. Mol. Cell 12 (2003) 829-839
    • (2003) Mol. Cell , vol.12 , pp. 829-839
    • Kato Jr., T.1    Delhase, M.2    Hoffmann, A.3    Karin, M.4
  • 7
    • 0031594708 scopus 로고    scopus 로고
    • Novel IkappaB alpha proteolytic pathway in WEHI231 immature B cells
    • Miyamoto S., Seufzer B.J., and Shumway S.D. Novel IkappaB alpha proteolytic pathway in WEHI231 immature B cells. Mol. Cell. Biol. 18 (1998) 19-29
    • (1998) Mol. Cell. Biol. , vol.18 , pp. 19-29
    • Miyamoto, S.1    Seufzer, B.J.2    Shumway, S.D.3
  • 8
    • 0029665597 scopus 로고    scopus 로고
    • Constitutive phosphorylation of IkappaBalpha by casein kinase II occurs preferentially at serine 293: requirement for degradation of free IkappaBalpha
    • Schwarz E.M., Van Antwerp D., and Verma I.M. Constitutive phosphorylation of IkappaBalpha by casein kinase II occurs preferentially at serine 293: requirement for degradation of free IkappaBalpha. Mol. Cell. Biol. 16 (1996) 3554-3559
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 3554-3559
    • Schwarz, E.M.1    Van Antwerp, D.2    Verma, I.M.3
  • 9
    • 0027243576 scopus 로고
    • p105 and p98 precursor proteins play an active role in NF-kappa B-mediated signal transduction
    • Mercurio F., DiDonato J.A., Rosette C., and Karin M. p105 and p98 precursor proteins play an active role in NF-kappa B-mediated signal transduction. Genes Dev. 7 (1993) 705-718
    • (1993) Genes Dev. , vol.7 , pp. 705-718
    • Mercurio, F.1    DiDonato, J.A.2    Rosette, C.3    Karin, M.4
  • 10
    • 0033532386 scopus 로고    scopus 로고
    • The IKKbeta subunit of IkappaB kinase (IKK) is essential for nuclear factor kappaB activation and prevention of apoptosis
    • Li Z.W., Chu W., Hu Y., Delhase M., Deerinck T., Ellisman M., Johnson R., and Karin M. The IKKbeta subunit of IkappaB kinase (IKK) is essential for nuclear factor kappaB activation and prevention of apoptosis. J. Exp. Med. 189 (1999) 1839-1845
    • (1999) J. Exp. Med. , vol.189 , pp. 1839-1845
    • Li, Z.W.1    Chu, W.2    Hu, Y.3    Delhase, M.4    Deerinck, T.5    Ellisman, M.6    Johnson, R.7    Karin, M.8
  • 11
  • 13
    • 0036234459 scopus 로고    scopus 로고
    • Missing pieces in the NF-kappaB puzzle
    • (Suppl.)
    • Ghosh S., and Karin M. Missing pieces in the NF-kappaB puzzle. Cell 109 (2002) S81-S96 (Suppl.)
    • (2002) Cell , vol.109
    • Ghosh, S.1    Karin, M.2
  • 14
    • 1642553460 scopus 로고    scopus 로고
    • To be, or not to be: NF-kappaB is the answer-Role of Rel/NF-kappaB in the regulation of apoptosis
    • Kucharczak J., Simmons M.J., Fan Y., and Gelinas C. To be, or not to be: NF-kappaB is the answer-Role of Rel/NF-kappaB in the regulation of apoptosis. Oncogene 22 (2003) 8961-8982
    • (2003) Oncogene , vol.22 , pp. 8961-8982
    • Kucharczak, J.1    Simmons, M.J.2    Fan, Y.3    Gelinas, C.4
  • 15
    • 0033596121 scopus 로고    scopus 로고
    • Activators and target genes of Rel/NF-kappaB transcription factors
    • Pahl H.L. Activators and target genes of Rel/NF-kappaB transcription factors. Oncogene 18 (1999) 6853-6866
    • (1999) Oncogene , vol.18 , pp. 6853-6866
    • Pahl, H.L.1
  • 17
    • 0028903216 scopus 로고
    • Members of the nuclear factor kappa B family transactivate the murine c-myb gene
    • Toth C.R., Hostutler R.F., Baldwin Jr. A.S., and Bender T.P. Members of the nuclear factor kappa B family transactivate the murine c-myb gene. J. Biol. Chem. 270 (1995) 7661-7671
    • (1995) J. Biol. Chem. , vol.270 , pp. 7661-7671
    • Toth, C.R.1    Hostutler, R.F.2    Baldwin Jr., A.S.3    Bender, T.P.4
  • 18
    • 0032588186 scopus 로고    scopus 로고
    • NF-kappaB controls cell growth and differentiation through transcriptional regulation of cyclin D1
    • Guttridge D.C., Albanese C., Reuther J.Y., Pestell R.G., and Baldwin Jr. A.S. NF-kappaB controls cell growth and differentiation through transcriptional regulation of cyclin D1. Mol. Cell. Biol. 19 (1999) 5785-5799
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 5785-5799
    • Guttridge, D.C.1    Albanese, C.2    Reuther, J.Y.3    Pestell, R.G.4    Baldwin Jr., A.S.5
  • 19
    • 0032588170 scopus 로고    scopus 로고
    • NF-kappaB function in growth control: regulation of cyclin D1 expression and G0/G1-to-S-phase transition
    • Hinz M., Krappmann D., Eichten A., Heder A., Scheidereit C., and Strauss M. NF-kappaB function in growth control: regulation of cyclin D1 expression and G0/G1-to-S-phase transition. Mol. Cell. Biol. 19 (1999) 2690-2698
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 2690-2698
    • Hinz, M.1    Krappmann, D.2    Eichten, A.3    Heder, A.4    Scheidereit, C.5    Strauss, M.6
  • 21
  • 22
    • 0037019172 scopus 로고    scopus 로고
    • Constitutive activation of NF-kappaB in Ki-ras-transformed prostate epithelial cells
    • Kim B.Y., Gaynor R.B., Song K., Dritschilo A., and Jung M. Constitutive activation of NF-kappaB in Ki-ras-transformed prostate epithelial cells. Oncogene 21 (2002) 4490-4497
    • (2002) Oncogene , vol.21 , pp. 4490-4497
    • Kim, B.Y.1    Gaynor, R.B.2    Song, K.3    Dritschilo, A.4    Jung, M.5
  • 25
    • 37049183697 scopus 로고
    • Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene
    • Slamon D.J., Clark G.M., Wong S.G., Levin W.J., Ullrich A., and McGuire W.L. Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. Science 235 (1987) 177-182
    • (1987) Science , vol.235 , pp. 177-182
    • Slamon, D.J.1    Clark, G.M.2    Wong, S.G.3    Levin, W.J.4    Ullrich, A.5    McGuire, W.L.6
  • 26
    • 0034327895 scopus 로고    scopus 로고
    • Assessment of methods for tissue-based detection of the HER-2/neu alteration in human breast cancer: a direct comparison of fluorescence in situ hybridization and immunohistochemistry
    • Pauletti G., Dandekar S., Rong H., Ramos L., Peng H., Seshadri R., and Slamon D.J. Assessment of methods for tissue-based detection of the HER-2/neu alteration in human breast cancer: a direct comparison of fluorescence in situ hybridization and immunohistochemistry. J. Clin. Oncol. 18 (2000) 3651-3664
    • (2000) J. Clin. Oncol. , vol.18 , pp. 3651-3664
    • Pauletti, G.1    Dandekar, S.2    Rong, H.3    Ramos, L.4    Peng, H.5    Seshadri, R.6    Slamon, D.J.7
  • 27
    • 0034677776 scopus 로고    scopus 로고
    • HER-2/neu blocks tumor necrosis factor-induced apoptosis via the Akt/NF-kappa B pathway
    • Zhou B.P., Hu M.C.-T., Miller S.A., Yu Z., Xia W., Lin S.-Y., and Hung M.-C. HER-2/neu blocks tumor necrosis factor-induced apoptosis via the Akt/NF-kappa B pathway. J. Biol. Chem. 275 (2000) 8027-8031
    • (2000) J. Biol. Chem. , vol.275 , pp. 8027-8031
    • Zhou, B.P.1    Hu, M.C.-T.2    Miller, S.A.3    Yu, Z.4    Xia, W.5    Lin, S.-Y.6    Hung, M.-C.7
  • 28
    • 0033031799 scopus 로고    scopus 로고
    • Matrix metalloproteinase 9 expression is induced by Epstein-Barr virus latent membrane protein 1 C-terminal activation regions 1 and 2
    • Takeshita H., Yoshizaki T., Miller W.E., Sato H., Furukawa M., Pagano J.S., and Raab-Traub N. Matrix metalloproteinase 9 expression is induced by Epstein-Barr virus latent membrane protein 1 C-terminal activation regions 1 and 2. J. Virol. 73 (1999) 5548-5555
    • (1999) J. Virol. , vol.73 , pp. 5548-5555
    • Takeshita, H.1    Yoshizaki, T.2    Miller, W.E.3    Sato, H.4    Furukawa, M.5    Pagano, J.S.6    Raab-Traub, N.7
  • 29
    • 0032508674 scopus 로고    scopus 로고
    • Synergistic upregulation of metalloproteinase-9 by growth factors and inflammatory cytokines: an absolute requirement for transcription factor NF-kappa B
    • Bond M., Fabunmi R.P., Baker A.H., and Newby A.C. Synergistic upregulation of metalloproteinase-9 by growth factors and inflammatory cytokines: an absolute requirement for transcription factor NF-kappa B. FEBS Lett. 435 (1998) 29-34
    • (1998) FEBS Lett. , vol.435 , pp. 29-34
    • Bond, M.1    Fabunmi, R.P.2    Baker, A.H.3    Newby, A.C.4
  • 30
    • 0027992051 scopus 로고
    • 12-O-tetradecanoylphorbol-13-acetate- and tumor necrosis factor alpha-mediated induction of intercellular adhesion molecule-1 is inhibited by dexamethasone. Functional analysis of the human intercellular adhesion molecular-1 promoter
    • van de Stolpe A., Caldenhoven E., Stade B.G., Koenderman L., Raaijmakers J.A., Johnson J.P., and van der Saag P.T. 12-O-tetradecanoylphorbol-13-acetate- and tumor necrosis factor alpha-mediated induction of intercellular adhesion molecule-1 is inhibited by dexamethasone. Functional analysis of the human intercellular adhesion molecular-1 promoter. J. Biol. Chem. 269 (1994) 6185-6192
    • (1994) J. Biol. Chem. , vol.269 , pp. 6185-6192
    • van de Stolpe, A.1    Caldenhoven, E.2    Stade, B.G.3    Koenderman, L.4    Raaijmakers, J.A.5    Johnson, J.P.6    van der Saag, P.T.7
  • 31
    • 4143134494 scopus 로고    scopus 로고
    • Nuclear factor-kappaB: a friend or a foe in cancer?
    • Shishodia S., and Aggarwal B.B. Nuclear factor-kappaB: a friend or a foe in cancer?. Biochem. Pharmacol. 68 (2004) 1071-1080
    • (2004) Biochem. Pharmacol. , vol.68 , pp. 1071-1080
    • Shishodia, S.1    Aggarwal, B.B.2
  • 35
    • 0035137882 scopus 로고    scopus 로고
    • Control of oncogenesis and cancer therapy resistance by the transcription factor NF-kappaB
    • Baldwin A.S. Control of oncogenesis and cancer therapy resistance by the transcription factor NF-kappaB. J. Clin. Invest. 107 (2001) 241-246
    • (2001) J. Clin. Invest. , vol.107 , pp. 241-246
    • Baldwin, A.S.1
  • 36
    • 33646006734 scopus 로고    scopus 로고
    • Signals from within: the DNA-damage-induced NF-kappaB response
    • Janssens S., and Tschopp J. Signals from within: the DNA-damage-induced NF-kappaB response. Cell Death Differ. (2006)
    • (2006) Cell Death Differ.
    • Janssens, S.1    Tschopp, J.2
  • 37
    • 28944447430 scopus 로고    scopus 로고
    • PIDD mediates NF-kappaB activation in response to DNA damage
    • Janssens S., Tinel A., Lippens S., and Tschopp J. PIDD mediates NF-kappaB activation in response to DNA damage. Cell 123 (2005) 1079-1092
    • (2005) Cell , vol.123 , pp. 1079-1092
    • Janssens, S.1    Tinel, A.2    Lippens, S.3    Tschopp, J.4
  • 38
    • 85047699198 scopus 로고    scopus 로고
    • Nuclear transcription factor-kappaB as a target for cancer drug development
    • Garg A., and Aggarwal B.B. Nuclear transcription factor-kappaB as a target for cancer drug development. Leukemia 16 (2002) 1053-1068
    • (2002) Leukemia , vol.16 , pp. 1053-1068
    • Garg, A.1    Aggarwal, B.B.2
  • 39
    • 0346505340 scopus 로고    scopus 로고
    • The IKK NF-kappa B system: a treasure trove for drug development
    • Karin M., Yamamoto Y., and Wang Q.M. The IKK NF-kappa B system: a treasure trove for drug development. Nat. Rev., Drug Discov. 3 (2004) 17-26
    • (2004) Nat. Rev., Drug Discov. , vol.3 , pp. 17-26
    • Karin, M.1    Yamamoto, Y.2    Wang, Q.M.3
  • 40
    • 16844366650 scopus 로고    scopus 로고
    • Nuclear factor-kappaB inhibitors as sensitizers to anticancer drugs
    • Nakanishi C., and Toi M. Nuclear factor-kappaB inhibitors as sensitizers to anticancer drugs. Nat. Rev., Cancer 5 (2005) 297-309
    • (2005) Nat. Rev., Cancer , vol.5 , pp. 297-309
    • Nakanishi, C.1    Toi, M.2
  • 41
    • 0035328584 scopus 로고    scopus 로고
    • Enhanced chemosensitivity to CPT-11 with proteasome inhibitor PS-341: implications for systemic nuclear factor-kappaB inhibition
    • Cusack Jr. J.C., Liu R., Houston M., Abendroth K., Elliott P.J., Adams J., and Baldwin Jr. A.S. Enhanced chemosensitivity to CPT-11 with proteasome inhibitor PS-341: implications for systemic nuclear factor-kappaB inhibition. Cancer Res. 61 (2001) 3535-3540
    • (2001) Cancer Res. , vol.61 , pp. 3535-3540
    • Cusack Jr., J.C.1    Liu, R.2    Houston, M.3    Abendroth, K.4    Elliott, P.J.5    Adams, J.6    Baldwin Jr., A.S.7
  • 42
    • 0034689773 scopus 로고    scopus 로고
    • Role of NF-kappaB in p53-mediated programmed cell death
    • Ryan K.M., Ernst M.K., Rice N.R., and Vousden K.H. Role of NF-kappaB in p53-mediated programmed cell death. Nature 404 (2000) 892-897
    • (2000) Nature , vol.404 , pp. 892-897
    • Ryan, K.M.1    Ernst, M.K.2    Rice, N.R.3    Vousden, K.H.4
  • 43
    • 2942716907 scopus 로고    scopus 로고
    • p53 induces NF-{kappa}B activation by an I{kappa}B kinase-independent mechanism involving phosphorylation of p65 by ribosomal S6 kinase 1
    • Bohuslav J., L.-f. Chen H., Kwon Y., and Mu W.C. p53 induces NF-{kappa}B activation by an I{kappa}B kinase-independent mechanism involving phosphorylation of p65 by ribosomal S6 kinase 1. J. Biol. Chem. 279 (2004) 26115-26125
    • (2004) J. Biol. Chem. , vol.279 , pp. 26115-26125
    • Bohuslav, J.1    L.-f. Chen, H.2    Kwon, Y.3    Mu, W.C.4
  • 44
    • 0032954928 scopus 로고    scopus 로고
    • Transcriptional cross talk between NF-kappaB and p53
    • Webster G.A., and Perkins N.D. Transcriptional cross talk between NF-kappaB and p53. Mol. Cell. Biol. 19 (1999) 3485-3495
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 3485-3495
    • Webster, G.A.1    Perkins, N.D.2
  • 45
    • 30944468153 scopus 로고    scopus 로고
    • Expression of the Bcl-3 proto-oncogene suppresses p53 activation
    • Kashatus D., Cogswell P., and Baldwin A.S. Expression of the Bcl-3 proto-oncogene suppresses p53 activation. Genes Dev. 20 (2006) 225-235
    • (2006) Genes Dev. , vol.20 , pp. 225-235
    • Kashatus, D.1    Cogswell, P.2    Baldwin, A.S.3
  • 46
    • 0036599406 scopus 로고    scopus 로고
    • p53 stabilization is decreased upon NFkappaB activation: a role for NFkappaB in acquisition of resistance to chemotherapy
    • Tergaonkar V., Pando M., Vafa O., Wahl G., and Verma I. p53 stabilization is decreased upon NFkappaB activation: a role for NFkappaB in acquisition of resistance to chemotherapy. Cancer Cell 1 (2002) 493-503
    • (2002) Cancer Cell , vol.1 , pp. 493-503
    • Tergaonkar, V.1    Pando, M.2    Vafa, O.3    Wahl, G.4    Verma, I.5
  • 47
    • 0035555653 scopus 로고    scopus 로고
    • relA over-expression reduces tumorigenicity and activates apoptosis in human cancer cells
    • Ricca A., Biroccio A., Trisciuoglio D., Cippitelli M., Zupi G., and Del Bufalo D. relA over-expression reduces tumorigenicity and activates apoptosis in human cancer cells. Br. J. Cancer 85 (2001) 1914-1921
    • (2001) Br. J. Cancer , vol.85 , pp. 1914-1921
    • Ricca, A.1    Biroccio, A.2    Trisciuoglio, D.3    Cippitelli, M.4    Zupi, G.5    Del Bufalo, D.6
  • 48
    • 0033605572 scopus 로고    scopus 로고
    • Overexpression of RelA causes G1 arrest and apoptosis in a pro-B cell line
    • Sheehy A.M., and Schlissel M.S. Overexpression of RelA causes G1 arrest and apoptosis in a pro-B cell line. J. Biol. Chem. 274 (1999) 8708-8716
    • (1999) J. Biol. Chem. , vol.274 , pp. 8708-8716
    • Sheehy, A.M.1    Schlissel, M.S.2
  • 49
    • 0033947601 scopus 로고    scopus 로고
    • The pro- or anti-apoptotic function of NF-kappaB is determined by the nature of the apoptotic stimulus
    • Kaltschmidt B., Kaltschmidt C., Hofmann T.G., Hehner S.P., Droge W., and Schmitz M.L. The pro- or anti-apoptotic function of NF-kappaB is determined by the nature of the apoptotic stimulus. Eur. J. Biochem. 267 (2000) 3828-3835
    • (2000) Eur. J. Biochem. , vol.267 , pp. 3828-3835
    • Kaltschmidt, B.1    Kaltschmidt, C.2    Hofmann, T.G.3    Hehner, S.P.4    Droge, W.5    Schmitz, M.L.6
  • 50
    • 0038439392 scopus 로고    scopus 로고
    • Stimulus-dependent activation of NF-kappaB specifies apoptosis or neuroprotection in cerebellar granule cells
    • Kaltschmidt B., Heinrich M., and Kaltschmidt C. Stimulus-dependent activation of NF-kappaB specifies apoptosis or neuroprotection in cerebellar granule cells. Neuromol. Med. 2 (2002) 299-309
    • (2002) Neuromol. Med. , vol.2 , pp. 299-309
    • Kaltschmidt, B.1    Heinrich, M.2    Kaltschmidt, C.3
  • 51
    • 3042545952 scopus 로고    scopus 로고
    • The role of NF-kappaB in 6-hydroxydopamine- and TNFalpha-induced apoptosis of PC12 cells
    • Tarabin V., and Schwaninger M. The role of NF-kappaB in 6-hydroxydopamine- and TNFalpha-induced apoptosis of PC12 cells. Naunyn-Schmiedeberg's Arch. Pharmacol. 369 (2004) 563-569
    • (2004) Naunyn-Schmiedeberg's Arch. Pharmacol. , vol.369 , pp. 563-569
    • Tarabin, V.1    Schwaninger, M.2
  • 53
    • 0037182755 scopus 로고    scopus 로고
    • The c-Rel transcription factor can both induce and inhibit apoptosis in the same cells via the upregulation of MnSOD
    • Bernard D., Monte D., Vandenbunder B., and Abbadie C. The c-Rel transcription factor can both induce and inhibit apoptosis in the same cells via the upregulation of MnSOD. Oncogene 21 (2002) 4392-4402
    • (2002) Oncogene , vol.21 , pp. 4392-4402
    • Bernard, D.1    Monte, D.2    Vandenbunder, B.3    Abbadie, C.4
  • 54
    • 0036792643 scopus 로고    scopus 로고
    • Tumor necrosis factor-related apoptosis inducing ligand (TRAIL) up-regulates death receptor 5 (DR5) mediated by NFkappaB activation in epithelial derived cell lines
    • Shetty S., Gladden J.B., Henson E.S., Hu X., Villanueva J., Haney N., and Gibson S.B. Tumor necrosis factor-related apoptosis inducing ligand (TRAIL) up-regulates death receptor 5 (DR5) mediated by NFkappaB activation in epithelial derived cell lines. Apoptosis 7 (2002) 413-420
    • (2002) Apoptosis , vol.7 , pp. 413-420
    • Shetty, S.1    Gladden, J.B.2    Henson, E.S.3    Hu, X.4    Villanueva, J.5    Haney, N.6    Gibson, S.B.7
  • 55
    • 20744433491 scopus 로고    scopus 로고
    • Transcription factor NF-kappaB differentially regulates death receptor 5 expression involving histone deacetylase 1
    • Shetty S., Graham B.A., Brown J.G., Hu X., Vegh-Yarema N., Harding G., Paul J.T., and Gibson S.B. Transcription factor NF-kappaB differentially regulates death receptor 5 expression involving histone deacetylase 1. Mol. Cell. Biol. 25 (2005) 5404-5416
    • (2005) Mol. Cell. Biol. , vol.25 , pp. 5404-5416
    • Shetty, S.1    Graham, B.A.2    Brown, J.G.3    Hu, X.4    Vegh-Yarema, N.5    Harding, G.6    Paul, J.T.7    Gibson, S.B.8
  • 58
    • 0035798624 scopus 로고    scopus 로고
    • NF-kappa B signaling pathway governs TRAIL gene expression and human T-cell leukemia virus-I tax-induced T-cell death
    • Rivera-Walsh I., Waterfield M., Xiao G., Fong A., and Sun S.-C. NF-kappa B signaling pathway governs TRAIL gene expression and human T-cell leukemia virus-I tax-induced T-cell death. J. Biol. Chem. 276 (2001) 40385-40388
    • (2001) J. Biol. Chem. , vol.276 , pp. 40385-40388
    • Rivera-Walsh, I.1    Waterfield, M.2    Xiao, G.3    Fong, A.4    Sun, S.-C.5
  • 59
    • 22244477083 scopus 로고    scopus 로고
    • Activation of nuclear factor-kappaB contributes to induction of death receptors and apoptosis by the synthetic retinoid CD437 in DU145 human prostate cancer cells
    • Jin F., Liu X., Zhou Z., Yue P., Lotan R., Khuri F.R., Chung L.W., and Sun S.Y. Activation of nuclear factor-kappaB contributes to induction of death receptors and apoptosis by the synthetic retinoid CD437 in DU145 human prostate cancer cells. Cancer Res. 65 (2005) 6354-6363
    • (2005) Cancer Res. , vol.65 , pp. 6354-6363
    • Jin, F.1    Liu, X.2    Zhou, Z.3    Yue, P.4    Lotan, R.5    Khuri, F.R.6    Chung, L.W.7    Sun, S.Y.8
  • 60
    • 19644366033 scopus 로고    scopus 로고
    • Apoptosis induction by a novel retinoid-related molecule requires nuclear factor-kappaB activation
    • Farhana L., Dawson M.I., and Fontana J.A. Apoptosis induction by a novel retinoid-related molecule requires nuclear factor-kappaB activation. Cancer Res. 65 (2005) 4909-4917
    • (2005) Cancer Res. , vol.65 , pp. 4909-4917
    • Farhana, L.1    Dawson, M.I.2    Fontana, J.A.3
  • 61
    • 0033621839 scopus 로고    scopus 로고
    • NFkappaB mediates apoptosis through transcriptional activation of Fas (CD95) in adenoviral hepatitis
    • Kuhnel F., Zender L., Paul Y., Tietze M.K., Trautwein C., Manns M., and Kubicka S. NFkappaB mediates apoptosis through transcriptional activation of Fas (CD95) in adenoviral hepatitis. J. Biol. Chem. 275 (2000) 6421-6427
    • (2000) J. Biol. Chem. , vol.275 , pp. 6421-6427
    • Kuhnel, F.1    Zender, L.2    Paul, Y.3    Tietze, M.K.4    Trautwein, C.5    Manns, M.6    Kubicka, S.7
  • 63
    • 0033560024 scopus 로고    scopus 로고
    • A critical role for the RelA subunit of nuclear factor kappaB in regulation of multiple immune-response genes and in Fas-induced cell death
    • Ouaaz F., Li M., and Beg A.A. A critical role for the RelA subunit of nuclear factor kappaB in regulation of multiple immune-response genes and in Fas-induced cell death. J. Exp. Med. 189 (1999) 999-1004
    • (1999) J. Exp. Med. , vol.189 , pp. 999-1004
    • Ouaaz, F.1    Li, M.2    Beg, A.A.3
  • 64
    • 0032014073 scopus 로고    scopus 로고
    • DNA damaging agents induce expression of Fas ligand and subsequent apoptosis in T lymphocytes via the activation of NF-kappa B and AP-1
    • Kasibhatla S., Brunner T., Genestier L., Echeverri F., Mahboubi A., and Green D.R. DNA damaging agents induce expression of Fas ligand and subsequent apoptosis in T lymphocytes via the activation of NF-kappa B and AP-1. Mol. Cell 1 (1998) 543-551
    • (1998) Mol. Cell , vol.1 , pp. 543-551
    • Kasibhatla, S.1    Brunner, T.2    Genestier, L.3    Echeverri, F.4    Mahboubi, A.5    Green, D.R.6
  • 65
    • 0034616122 scopus 로고    scopus 로고
    • Regulation of FasL by NF-kappaB and AP-1 in Fas-dependent thymineless death of human colon carcinoma cells
    • Harwood F.G., Kasibhatla S., Petak I., Vernes R., Green D.R., and Houghton J.A. Regulation of FasL by NF-kappaB and AP-1 in Fas-dependent thymineless death of human colon carcinoma cells. J. Biol. Chem. 275 (2000) 10023-10029
    • (2000) J. Biol. Chem. , vol.275 , pp. 10023-10029
    • Harwood, F.G.1    Kasibhatla, S.2    Petak, I.3    Vernes, R.4    Green, D.R.5    Houghton, J.A.6
  • 66
    • 0028167599 scopus 로고
    • NF-kappa B activation of p53. A potential mechanism for suppressing cell growth in response to stress
    • Wu H., and Lozano G. NF-kappa B activation of p53. A potential mechanism for suppressing cell growth in response to stress. J. Biol. Chem. 269 (1994) 20067-20074
    • (1994) J. Biol. Chem. , vol.269 , pp. 20067-20074
    • Wu, H.1    Lozano, G.2
  • 67
    • 0034726961 scopus 로고    scopus 로고
    • Additive effect between NF-kappaB subunits and p53 protein for transcriptional activation of human p53 promoter
    • Benoit V., Hellin A.C., Huygen S., Gielen J., Bours V., and Merville M.P. Additive effect between NF-kappaB subunits and p53 protein for transcriptional activation of human p53 promoter. Oncogene 19 (2000) 4787-4794
    • (2000) Oncogene , vol.19 , pp. 4787-4794
    • Benoit, V.1    Hellin, A.C.2    Huygen, S.3    Gielen, J.4    Bours, V.5    Merville, M.P.6
  • 68
    • 0033614370 scopus 로고    scopus 로고
    • Expression of human p53 requires synergistic activation of transcription from the p53 promoter by AP-1, NF-kappaB and Myc/Max
    • Kirch H.C., Flaswinkel S., Rumpf H., Brockmann D., and Esche H. Expression of human p53 requires synergistic activation of transcription from the p53 promoter by AP-1, NF-kappaB and Myc/Max. Oncogene 18 (1999) 2728-2738
    • (1999) Oncogene , vol.18 , pp. 2728-2738
    • Kirch, H.C.1    Flaswinkel, S.2    Rumpf, H.3    Brockmann, D.4    Esche, H.5
  • 70
    • 0035983531 scopus 로고    scopus 로고
    • NF-kappaB-mediated up-regulation of Bcl-X(S) and Bax contributes to cytochrome c release in cyanide-induced apoptosis
    • Shou Y., Li N., Li L., Borowitz J.L., and Isom G.E. NF-kappaB-mediated up-regulation of Bcl-X(S) and Bax contributes to cytochrome c release in cyanide-induced apoptosis. J. Neurochem. 81 (2002) 842-852
    • (2002) J. Neurochem. , vol.81 , pp. 842-852
    • Shou, Y.1    Li, N.2    Li, L.3    Borowitz, J.L.4    Isom, G.E.5
  • 71
    • 0037031848 scopus 로고    scopus 로고
    • p38 kinase regulates nitric oxide-induced apoptosis of articular chondrocytes by accumulating p53 via NFkappa B-dependent transcription and stabilization by serine 15 phosphorylation
    • Kim S.J., Hwang S.G., Shin D.Y., Kang S.S., and Chun J.S. p38 kinase regulates nitric oxide-induced apoptosis of articular chondrocytes by accumulating p53 via NFkappa B-dependent transcription and stabilization by serine 15 phosphorylation. J. Biol. Chem. 277 (2002) 33501-33508
    • (2002) J. Biol. Chem. , vol.277 , pp. 33501-33508
    • Kim, S.J.1    Hwang, S.G.2    Shin, D.Y.3    Kang, S.S.4    Chun, J.S.5
  • 72
    • 0033561799 scopus 로고    scopus 로고
    • Nuclear factor kappaB nuclear translocation upregulates c-Myc and p53 expression during NMDA receptor-mediated apoptosis in rat striatum
    • Qin Z.H., Chen R.W., Wang Y., Nakai M., Chuang D.M., and Chase T.N. Nuclear factor kappaB nuclear translocation upregulates c-Myc and p53 expression during NMDA receptor-mediated apoptosis in rat striatum. J. Neurosci. 19 (1999) 4023-4033
    • (1999) J. Neurosci. , vol.19 , pp. 4023-4033
    • Qin, Z.H.1    Chen, R.W.2    Wang, Y.3    Nakai, M.4    Chuang, D.M.5    Chase, T.N.6
  • 73
    • 20144384882 scopus 로고    scopus 로고
    • Lost in transcription: p21 repression, mechanisms, and consequences
    • Gartel A.L., and Radhakrishnan S.K. Lost in transcription: p21 repression, mechanisms, and consequences. Cancer Res. 65 (2005) 3980-3985
    • (2005) Cancer Res. , vol.65 , pp. 3980-3985
    • Gartel, A.L.1    Radhakrishnan, S.K.2
  • 75
    • 20444444295 scopus 로고    scopus 로고
    • Function of polo-like kinase 3 in NF-{kappa}B-mediated proapoptotic response
    • Li Z., Niu J., Uwagawa T., Peng B., and Chiao P.J. Function of polo-like kinase 3 in NF-{kappa}B-mediated proapoptotic response. J. Biol. Chem. 280 (2005) 16843-16850
    • (2005) J. Biol. Chem. , vol.280 , pp. 16843-16850
    • Li, Z.1    Niu, J.2    Uwagawa, T.3    Peng, B.4    Chiao, P.J.5
  • 76
    • 21444459126 scopus 로고    scopus 로고
    • Protein kinase C-dependent regulation of NAG-1/placental bone morphogenic protein/MIC-1 expression in LNCaP prostate carcinoma cells
    • Shim M., and Eling T.E. Protein kinase C-dependent regulation of NAG-1/placental bone morphogenic protein/MIC-1 expression in LNCaP prostate carcinoma cells. J. Biol. Chem. 280 (2005) 18636-18642
    • (2005) J. Biol. Chem. , vol.280 , pp. 18636-18642
    • Shim, M.1    Eling, T.E.2
  • 81
    • 1842526076 scopus 로고    scopus 로고
    • Active repression of antiapoptotic gene expression by RelA(p65) NF-kappa B
    • Campbell K.J., Rocha S., and Perkins N.D. Active repression of antiapoptotic gene expression by RelA(p65) NF-kappa B. Mol. Cell 13 (2004) 853-865
    • (2004) Mol. Cell , vol.13 , pp. 853-865
    • Campbell, K.J.1    Rocha, S.2    Perkins, N.D.3
  • 82
    • 0043172452 scopus 로고    scopus 로고
    • p53- and Mdm2-independent repression of NF-kappa B transactivation by the ARF tumor suppressor
    • Rocha S., Campbell K.J., and Perkins N.D. p53- and Mdm2-independent repression of NF-kappa B transactivation by the ARF tumor suppressor. Mol. Cell 12 (2003) 15-25
    • (2003) Mol. Cell , vol.12 , pp. 15-25
    • Rocha, S.1    Campbell, K.J.2    Perkins, N.D.3
  • 83
    • 17144422434 scopus 로고    scopus 로고
    • Regulation of NF-kappaB and p53 through activation of ATR and Chk1 by the ARF tumour suppressor
    • Rocha S., Garrett M.D., Campbell K.J., Schumm K., and Perkins N.D. Regulation of NF-kappaB and p53 through activation of ATR and Chk1 by the ARF tumour suppressor. EMBO J. 24 (2005) 1157-1169
    • (2005) EMBO J. , vol.24 , pp. 1157-1169
    • Rocha, S.1    Garrett, M.D.2    Campbell, K.J.3    Schumm, K.4    Perkins, N.D.5
  • 84
    • 25144473970 scopus 로고    scopus 로고
    • ARF the integrator: linking NF-kappaB, p53 and checkpoint kinases
    • Rocha S., and Perkins N.D. ARF the integrator: linking NF-kappaB, p53 and checkpoint kinases. Cell Cycle 4 (2005) 756-759
    • (2005) Cell Cycle , vol.4 , pp. 756-759
    • Rocha, S.1    Perkins, N.D.2
  • 85
    • 31544481844 scopus 로고    scopus 로고
    • Cisplatin mimics ARF tumor suppressor regulation of RelA (p65) nuclear factor-{kappa}B transactivation
    • Campbell K.J., Witty J.M., Rocha S., and Perkins N.D. Cisplatin mimics ARF tumor suppressor regulation of RelA (p65) nuclear factor-{kappa}B transactivation. Cancer Res. 66 (2006) 929-935
    • (2006) Cancer Res. , vol.66 , pp. 929-935
    • Campbell, K.J.1    Witty, J.M.2    Rocha, S.3    Perkins, N.D.4
  • 86
    • 18144371109 scopus 로고    scopus 로고
    • NF{kappa}B-dependent down-regulation of tumor necrosis factor receptor-associated proteins contributes to interleukin-1-mediated enhancement of ultraviolet B-induced apoptosis
    • Poppelmann B., Klimmek K., Strozyk E., Voss R., Schwarz T., and Kulms D. NF{kappa}B-dependent down-regulation of tumor necrosis factor receptor-associated proteins contributes to interleukin-1-mediated enhancement of ultraviolet B-induced apoptosis. J. Biol. Chem. 280 (2005) 15635-15643
    • (2005) J. Biol. Chem. , vol.280 , pp. 15635-15643
    • Poppelmann, B.1    Klimmek, K.2    Strozyk, E.3    Voss, R.4    Schwarz, T.5    Kulms, D.6
  • 89
    • 0037498747 scopus 로고    scopus 로고
    • Is NF-kappaB2/p100 a direct activator of programmed cell death?
    • Hacker H., and Karin M. Is NF-kappaB2/p100 a direct activator of programmed cell death?. Cancer Cell 2 (2002) 431-433
    • (2002) Cancer Cell , vol.2 , pp. 431-433
    • Hacker, H.1    Karin, M.2
  • 90
    • 26444605834 scopus 로고    scopus 로고
    • IKK/NF-{kappa}B signaling: balancing life and death-A new approach to cancer therapy
    • Luo J.-L., Kamata H., and Karin M. IKK/NF-{kappa}B signaling: balancing life and death-A new approach to cancer therapy. J. Clin. Invest. 115 (2005) 2625-2632
    • (2005) J. Clin. Invest. , vol.115 , pp. 2625-2632
    • Luo, J.-L.1    Kamata, H.2    Karin, M.3
  • 91
    • 1642579534 scopus 로고    scopus 로고
    • Evidence that activation of nuclear factor-kappaB is essential for the cytotoxic effects of doxorubicin and its analogues
    • Ashikawa K., Shishodia S., Fokt I., Priebe W., and Aggarwal B.B. Evidence that activation of nuclear factor-kappaB is essential for the cytotoxic effects of doxorubicin and its analogues. Biochem. Pharmacol. 67 (2004) 353-364
    • (2004) Biochem. Pharmacol. , vol.67 , pp. 353-364
    • Ashikawa, K.1    Shishodia, S.2    Fokt, I.3    Priebe, W.4    Aggarwal, B.B.5
  • 92
    • 0037050235 scopus 로고    scopus 로고
    • TRAIL and inhibitors of apoptosis are opposing determinants for NF-kappaB-dependent, genotoxin-induced apoptosis of cancer cells
    • Spalding A.C., Jotte R.M., Scheinman R.I., Geraci M.W., Clarke P., Tyler K.L., and Johnson G.L. TRAIL and inhibitors of apoptosis are opposing determinants for NF-kappaB-dependent, genotoxin-induced apoptosis of cancer cells. Oncogene 21 (2002) 260-271
    • (2002) Oncogene , vol.21 , pp. 260-271
    • Spalding, A.C.1    Jotte, R.M.2    Scheinman, R.I.3    Geraci, M.W.4    Clarke, P.5    Tyler, K.L.6    Johnson, G.L.7
  • 94
    • 26944478633 scopus 로고    scopus 로고
    • Immortalized fibroblasts from NF-kappaB RelA knockout mice show phenotypic heterogeneity and maintain increased sensitivity to tumor necrosis factor alpha after transformation by v-Ras
    • Gapuzan M.E., Schmah O., Pollock A.D., Hoffmann A., and Gilmore T.D. Immortalized fibroblasts from NF-kappaB RelA knockout mice show phenotypic heterogeneity and maintain increased sensitivity to tumor necrosis factor alpha after transformation by v-Ras. Oncogene 24 (2005) 6574-6583
    • (2005) Oncogene , vol.24 , pp. 6574-6583
    • Gapuzan, M.E.1    Schmah, O.2    Pollock, A.D.3    Hoffmann, A.4    Gilmore, T.D.5
  • 95
    • 0037061742 scopus 로고    scopus 로고
    • Immortalized embryonic mouse fibroblasts lacking the RelA subunit of transcription factor NF-kappaB have a malignantly transformed phenotype
    • Gapuzan M.E., Yufit P.V., and Gilmore T.D. Immortalized embryonic mouse fibroblasts lacking the RelA subunit of transcription factor NF-kappaB have a malignantly transformed phenotype. Oncogene 21 (2002) 2484-2492
    • (2002) Oncogene , vol.21 , pp. 2484-2492
    • Gapuzan, M.E.1    Yufit, P.V.2    Gilmore, T.D.3
  • 96
    • 10644248286 scopus 로고    scopus 로고
    • Post-translational modification of RelA(p65) NF-kappaB
    • Campbell K.J., and Perkins N.D. Post-translational modification of RelA(p65) NF-kappaB. Biochem. Soc. Trans. 32 (2004) 1087-1089
    • (2004) Biochem. Soc. Trans. , vol.32 , pp. 1087-1089
    • Campbell, K.J.1    Perkins, N.D.2
  • 97
    • 4143083971 scopus 로고    scopus 로고
    • Regulation at multiple levels of NF-kappaB-mediated transactivation by protein acetylation
    • Quivy V., and Van Lint C. Regulation at multiple levels of NF-kappaB-mediated transactivation by protein acetylation. Biochem. Pharmacol. 68 (2004) 1221-1229
    • (2004) Biochem. Pharmacol. , vol.68 , pp. 1221-1229
    • Quivy, V.1    Van Lint, C.2
  • 98
    • 0037011056 scopus 로고    scopus 로고
    • Acetylation of RelA at discrete sites regulates distinct nuclear functions of NF-kappaB
    • Chen L.F., Mu Y., and Greene W.C. Acetylation of RelA at discrete sites regulates distinct nuclear functions of NF-kappaB. EMBO J. 21 (2002) 6539-6548
    • (2002) EMBO J. , vol.21 , pp. 6539-6548
    • Chen, L.F.1    Mu, Y.2    Greene, W.C.3
  • 100
    • 12844286907 scopus 로고    scopus 로고
    • cis-acting element-specific transcriptional activity of differentially phosphorylated nuclear factor-{kappa}B
    • Anrather J., Racchumi G., and Iadecola C. cis-acting element-specific transcriptional activity of differentially phosphorylated nuclear factor-{kappa}B. J. Biol. Chem. 280 (2005) 244-252
    • (2005) J. Biol. Chem. , vol.280 , pp. 244-252
    • Anrather, J.1    Racchumi, G.2    Iadecola, C.3
  • 101
    • 9644262497 scopus 로고    scopus 로고
    • Phosphorylation of serine 468 by GSK-3beta negatively regulates basal p65 NF-kappaB activity
    • Buss H., Dorrie A., Schmitz M.L., Frank R., Livingstone M., Resch K., and Kracht M. Phosphorylation of serine 468 by GSK-3beta negatively regulates basal p65 NF-kappaB activity. J. Biol. Chem. 279 (2004) 49571-49574
    • (2004) J. Biol. Chem. , vol.279 , pp. 49571-49574
    • Buss, H.1    Dorrie, A.2    Schmitz, M.L.3    Frank, R.4    Livingstone, M.5    Resch, K.6    Kracht, M.7
  • 102
    • 25444530592 scopus 로고    scopus 로고
    • Glycogen synthase kinase 3beta functions to specify gene-specific, NF-kappaB-dependent transcription
    • Steinbrecher K.A., Wilson III W., Cogswell P.C., and Baldwin A.S. Glycogen synthase kinase 3beta functions to specify gene-specific, NF-kappaB-dependent transcription. Mol. Cell. Biol. 25 (2005) 8444-8455
    • (2005) Mol. Cell. Biol. , vol.25 , pp. 8444-8455
    • Steinbrecher, K.A.1    Wilson III, W.2    Cogswell, P.C.3    Baldwin, A.S.4
  • 104
    • 1842421811 scopus 로고    scopus 로고
    • RelA life and death decisions
    • Miyamoto S. RelA life and death decisions. Mol. Cell 13 (2004) 763-764
    • (2004) Mol. Cell , vol.13 , pp. 763-764
    • Miyamoto, S.1
  • 105
    • 26444538871 scopus 로고    scopus 로고
    • The two faces of NFkappaB in cell survival responses
    • Graham B., and Gibson S.B. The two faces of NFkappaB in cell survival responses. Cell Cycle 4 (2005) 1342-1345
    • (2005) Cell Cycle , vol.4 , pp. 1342-1345
    • Graham, B.1    Gibson, S.B.2
  • 106
    • 0036143654 scopus 로고    scopus 로고
    • p38-Dependent marking of inflammatory genes for increased NF-kappa B recruitment
    • Saccani S., Pantano S., and Natoli G. p38-Dependent marking of inflammatory genes for increased NF-kappa B recruitment. Nat. Immunol. 3 (2002) 69-75
    • (2002) Nat. Immunol. , vol.3 , pp. 69-75
    • Saccani, S.1    Pantano, S.2    Natoli, G.3
  • 107
    • 33645971047 scopus 로고    scopus 로고
    • Good cop, bad cop: the different faces of NF-kappaB
    • (in press)
    • Perkins N.D., and Gilmore T.D. Good cop, bad cop: the different faces of NF-kappaB. Cell Death Differ. (2006) (in press)
    • (2006) Cell Death Differ.
    • Perkins, N.D.1    Gilmore, T.D.2
  • 108
    • 0442323562 scopus 로고    scopus 로고
    • NF-kappaB: tumor promoter or suppressor?
    • Perkins N.D. NF-kappaB: tumor promoter or suppressor?. Trends Cell Biol. 14 (2004) 64-69
    • (2004) Trends Cell Biol. , vol.14 , pp. 64-69
    • Perkins, N.D.1
  • 109
    • 0036594890 scopus 로고    scopus 로고
    • The role of the cyclin-dependent kinase inhibitor p21 in apoptosis
    • Gartel A.L., and Tyner A.L. The role of the cyclin-dependent kinase inhibitor p21 in apoptosis. Mol. Cancer Ther. 1 (2002) 639-649
    • (2002) Mol. Cancer Ther. , vol.1 , pp. 639-649
    • Gartel, A.L.1    Tyner, A.L.2
  • 110
    • 0035902115 scopus 로고    scopus 로고
    • Proliferation, cell cycle and apoptosis in cancer
    • Evan G.I., and Vousden K.H. Proliferation, cell cycle and apoptosis in cancer. Nature 411 (2001) 342-348
    • (2001) Nature , vol.411 , pp. 342-348
    • Evan, G.I.1    Vousden, K.H.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.