-
1
-
-
0038483826
-
Emergence of scaling in random networks
-
Barabasi,A.L. and Albert,R. (1999) Emergence of scaling in random networks. Science, 286, 509-512.
-
(1999)
Science
, vol.286
, pp. 509-512
-
-
Barabasi, A.L.1
Albert, R.2
-
2
-
-
36349011849
-
Genes2Networks: Connecting lists of gene symbols using mammalian protein interactions databases
-
Berger,S.I. et al. (2007) Genes2Networks: Connecting lists of gene symbols using mammalian protein interactions databases. BMC Bioinformatics, 8, 372.
-
(2007)
BMC Bioinformatics
, vol.8
, pp. 372
-
-
Berger, S.I.1
-
3
-
-
44249113841
-
Design logic of a cannabinoid receptor signaling network that triggers neurite outgrowth
-
Bromberg,K.D. et al. (2008) Design logic of a cannabinoid receptor signaling network that triggers neurite outgrowth. Science, 320 903-909.
-
(2008)
Science
, vol.320
, pp. 903-909
-
-
Bromberg, K.D.1
-
4
-
-
33845748185
-
Disrupted in Schizophrenia 1 Interactome: Evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia
-
Camargo,L.M. et al. (2007) Disrupted in Schizophrenia 1 Interactome: Evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia. Mol. Psychiatry, 12 74-86.
-
(2007)
Mol. Psychiatry
, vol.12
, pp. 74-86
-
-
Camargo, L.M.1
-
5
-
-
47249146126
-
Drug target identification using side-effect similarity
-
Campillos,M. et al. (2008) Drug target identification using side-effect similarity. Science, 321, 263-266.
-
(2008)
Science
, vol.321
, pp. 263-266
-
-
Campillos, M.1
-
6
-
-
62849126285
-
Disease candidate gene identification and prioritization using protein interaction networks
-
Chen,J. et al. (2009) Disease candidate gene identification and prioritization using protein interaction networks. BMC Bioinformatics 10, 73.
-
(2009)
BMC Bioinformatics
, vol.10
, pp. 73
-
-
Chen, J.1
-
7
-
-
48549092620
-
-
Chu,L.H. and Chen,B.S. (2008) Construction of a cancer-perturbed protein-protein interaction network for discovery of apoptosis drug targets. BMC Syst. Biol., 2, 56.
-
Chu,L.H. and Chen,B.S. (2008) Construction of a cancer-perturbed protein-protein interaction network for discovery of apoptosis drug targets. BMC Syst. Biol., 2, 56.
-
-
-
-
8
-
-
33745764032
-
A computational framework for the topological analysis and targeted disruption of signal transduction networks
-
Dasika,M.S. et al. (2006) A computational framework for the topological analysis and targeted disruption of signal transduction networks. Biophys J., 91, 382-398.
-
(2006)
Biophys J
, vol.91
, pp. 382-398
-
-
Dasika, M.S.1
-
9
-
-
62049085339
-
Drug targets for tumorigenesis: Insights from structural analysis of EGFR signaling network
-
Durmus Tekir,S. et al. (2009) Drug targets for tumorigenesis: insights from structural analysis of EGFR signaling network. J. Biomed. Inform., 42, 228-236.
-
(2009)
J. Biomed. Inform
, vol.42
, pp. 228-236
-
-
Durmus Tekir, S.1
-
10
-
-
64549142857
-
Estimating novel potential drug targets of Plasmodium falciparum by analysing the metabolic network of knock-out strains in silico
-
Fatumo,S. et al. (2009) Estimating novel potential drug targets of Plasmodium falciparum by analysing the metabolic network of knock-out strains in silico. Infect. Genet. Evol., 9, 351-358.
-
(2009)
Infect. Genet. Evol
, vol.9
, pp. 351-358
-
-
Fatumo, S.1
-
11
-
-
34547140875
-
The human disease network
-
Goh,K.I. et al. (2007) The human disease network. Proc. Natl Acad. Sci. USA, 104, 8685-8690.
-
(2007)
Proc. Natl Acad. Sci. USA
, vol.104
, pp. 8685-8690
-
-
Goh, K.I.1
-
12
-
-
67651166638
-
Generating genome-scale candidate gene lists for pharmacogenomics
-
Hansen,N. et al. (2009) Generating genome-scale candidate gene lists for pharmacogenomics. Clin. Pharmacol. Ther., 86, 183-189.
-
(2009)
Clin. Pharmacol. Ther
, vol.86
, pp. 183-189
-
-
Hansen, N.1
-
13
-
-
44449159422
-
Quantifying the relationships among drug classes
-
Hert,J. et al. (2008) Quantifying the relationships among drug classes. J. Chem. Inf. Model, 48, 755-765.
-
(2008)
J. Chem. Inf. Model
, vol.48
, pp. 755-765
-
-
Hert, J.1
-
14
-
-
33644524405
-
Are hERG channel inhibition and QT interval prolongation all there is in drug-induced torsadogenesis? A review of emerging trends
-
Hoffmann,P. and Warner,B. (2006) Are hERG channel inhibition and QT interval prolongation all there is in drug-induced torsadogenesis? A review of emerging trends. J. Pharmacol. Toxicol. Methods, 53 87-105.
-
(2006)
J. Pharmacol. Toxicol. Methods
, vol.53
, pp. 87-105
-
-
Hoffmann, P.1
Warner, B.2
-
15
-
-
44449119819
-
Aprotein interaction network associated with asthma
-
Hwang,S. et al. (2008a)Aprotein interaction network associated with asthma. J. Theor. Biol., 252, 722-731.
-
(2008)
J. Theor. Biol
, vol.252
, pp. 722-731
-
-
Hwang, S.1
-
16
-
-
54349093738
-
Identification of information flow-modulating drug targets: A novel bridging paradigm for drug discovery
-
Hwang,W.C. et al. (2008b) Identification of information flow-modulating drug targets: A novel bridging paradigm for drug discovery. Clin. Pharmacol. Ther., 84, 563-572.
-
(2008)
Clin. Pharmacol. Ther
, vol.84
, pp. 563-572
-
-
Hwang, W.C.1
-
17
-
-
34347250494
-
Integrated network analysis identifies nitric oxide response networks and dihydroxyacid dehydratase as a crucial target in Escherichia coli
-
Hyduke,D.R. et al. (2007) Integrated network analysis identifies nitric oxide response networks and dihydroxyacid dehydratase as a crucial target in Escherichia coli. Proc. Natl Acad. Sci. USA, 104, 8484-8489.
-
(2007)
Proc. Natl Acad. Sci. USA
, vol.104
, pp. 8484-8489
-
-
Hyduke, D.R.1
-
18
-
-
59649109178
-
Identifying network of drug mode of action by gene expression profiling
-
Iorio,F. et al. (2009) Identifying network of drug mode of action by gene expression profiling. J. Comput. Biol., 16, 241-251.
-
(2009)
J. Comput. Biol
, vol.16
, pp. 241-251
-
-
Iorio, F.1
-
19
-
-
0034609791
-
The large-scale organization of metabolic networks
-
Jeong,H. et al. (2000) The large-scale organization of metabolic networks. Nature, 407, 651-654.
-
(2000)
Nature
, vol.407
, pp. 651-654
-
-
Jeong, H.1
-
20
-
-
0035799707
-
Lethality and centrality in protein networks
-
Jeong,H. et al. (2001) Lethality and centrality in protein networks. Nature, 411, 41-42.
-
(2001)
Nature
, vol.411
, pp. 41-42
-
-
Jeong, H.1
-
21
-
-
65449187535
-
Evolutionary rates and centrality in the yeast gene regulatory network
-
Jovelin,R. and Phillips,P.C. (2009) Evolutionary rates and centrality in the yeast gene regulatory network. Genome Biol., 10, R35.
-
(2009)
Genome Biol
, vol.10
-
-
Jovelin, R.1
Phillips, P.C.2
-
22
-
-
33846876695
-
Relating protein pharmacology by ligand chemistry
-
Keiser,M.J. et al. (2007) Relating protein pharmacology by ligand chemistry. Nat. Biotechnol., 25, 197-206.
-
(2007)
Nat. Biotechnol
, vol.25
, pp. 197-206
-
-
Keiser, M.J.1
-
23
-
-
41549139527
-
Walking the interactome for prioritization of candidate disease genes
-
Kohler,S. et al. (2008) Walking the interactome for prioritization of candidate disease genes. Am. J. Hum. Genet., 82, 949-958.
-
(2008)
Am. J. Hum. Genet
, vol.82
, pp. 949-958
-
-
Kohler, S.1
-
24
-
-
33646687963
-
A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration
-
Lim,J. et al. (2006) A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. Cell, 125, 801-814.
-
(2006)
Cell
, vol.125
, pp. 801-814
-
-
Lim, J.1
-
25
-
-
33846681448
-
Modular organization of protein interaction networks
-
Luo,F. et al. (2007) Modular organization of protein interaction networks. Bioinformatics, 23, 207-214.
-
(2007)
Bioinformatics
, vol.23
, pp. 207-214
-
-
Luo, F.1
-
26
-
-
23644437498
-
Formation of regulatory patterns during signal propagation in a Mammalian cellular network
-
Ma'ayan,A. et al. (2005) Formation of regulatory patterns during signal propagation in a Mammalian cellular network. Science, 309, 1078-1083.
-
(2005)
Science
, vol.309
, pp. 1078-1083
-
-
Ma'ayan, A.1
-
27
-
-
34250777249
-
Network analysis of FDA approved drugs and their targets
-
Ma'ayan,A. et al. (2007) Network analysis of FDA approved drugs and their targets. Mt. Sinai. J. Med., 74, 27-32.
-
(2007)
Mt. Sinai. J. Med
, vol.74
, pp. 27-32
-
-
Ma'ayan, A.1
-
28
-
-
65449170041
-
JNets: Exploring networks by integrating annotation
-
Macpherson,J.I. et al. (2009) JNets: Exploring networks by integrating annotation. BMC Bioinformatics, 10, 95.
-
(2009)
BMC Bioinformatics
, vol.10
, pp. 95
-
-
Macpherson, J.I.1
-
29
-
-
0037174670
-
Network motifs: Simple building blocks of complex networks
-
Milo,R. et al. (2002) Network motifs: Simple building blocks of complex networks. Science, 298, 824-827.
-
(2002)
Science
, vol.298
, pp. 824-827
-
-
Milo, R.1
-
30
-
-
43249109885
-
Network topology determines dynamics of the mammalian MAPK1,2 signaling network: Bifan motif regulation of C-Raf and B-Raf isoforms by FGFR and MC1R
-
Muller,M. et al. (2008) Network topology determines dynamics of the mammalian MAPK1,2 signaling network: Bifan motif regulation of C-Raf and B-Raf isoforms by FGFR and MC1R. FASEB J., 22, 1393-1403.
-
(2008)
FASEB J
, vol.22
, pp. 1393-1403
-
-
Muller, M.1
-
31
-
-
42349096647
-
A global view of drug-therapy interactions
-
Nacher,J.C. and Schwartz,J.M. (2008)A global view of drug-therapy interactions. BMC Pharmacol., 8, 5.
-
(2008)
BMC Pharmacol
, vol.8
, pp. 5
-
-
Nacher, J.C.1
Schwartz, J.M.2
-
32
-
-
46249127253
-
Identifying gene-disease associations using centrality on a literature mined gene-interaction network
-
Ozgur,A. et al. (2008) Identifying gene-disease associations using centrality on a literature mined gene-interaction network. Bioinformatics, 24, i277-i285.
-
(2008)
Bioinformatics
, vol.24
-
-
Ozgur, A.1
-
33
-
-
65549134255
-
Inferring novel disease indications for known drugs by semantically linking drug action and disease mechanism relationships
-
Qu,X.A. et al. (2009) Inferring novel disease indications for known drugs by semantically linking drug action and disease mechanism relationships. BMC Bioinformatics, 10 (Suppl. 5), S4.
-
(2009)
BMC Bioinformatics
, vol.10
, Issue.SUPPL. 5
-
-
Qu, X.A.1
-
34
-
-
61649095940
-
Mycobacterium tuberculosis interactome analysis unravels potential pathways to drug resistance
-
Raman,K. and Chandra,N. (2008) Mycobacterium tuberculosis interactome analysis unravels potential pathways to drug resistance. BMC Microbiol., 8, 234.
-
(2008)
BMC Microbiol
, vol.8
, pp. 234
-
-
Raman, K.1
Chandra, N.2
-
35
-
-
33845355240
-
Hypothesis generation in signaling networks
-
Ruths,D.A. et al. (2006) Hypothesis generation in signaling networks. J. Comput. Biol., 13, 1546-1557.
-
(2006)
J. Comput. Biol
, vol.13
, pp. 1546-1557
-
-
Ruths, D.A.1
-
36
-
-
66249139112
-
Choke point analysis of metabolic pathways in E.histolytica: A computational approach for drug target identification
-
Singh,S. et al. (2007) Choke point analysis of metabolic pathways in E.histolytica: A computational approach for drug target identification. Bioinformation, 2, 68-72.
-
(2007)
Bioinformation
, vol.2
, pp. 68-72
-
-
Singh, S.1
-
37
-
-
38449123881
-
An iterative algorithm for metabolic network-based drug target identification
-
Sridhar,P. et al. (2007) An iterative algorithm for metabolic network-based drug target identification. Pac. Symp. Biocomput., 12, 88-99.
-
(2007)
Pac. Symp. Biocomput
, vol.12
, pp. 88-99
-
-
Sridhar, P.1
-
38
-
-
40549083075
-
Mining metabolic networks for optimal drug targets
-
Sridhar,P. et al. (2008) Mining metabolic networks for optimal drug targets. Pac. Symp. Biocomput., 13, 291-302.
-
(2008)
Pac. Symp. Biocomput
, vol.13
, pp. 291-302
-
-
Sridhar, P.1
-
39
-
-
35348988164
-
Network analysis of oncogenic Ras activation in cancer
-
Stites,E.C. et al. (2007) Network analysis of oncogenic Ras activation in cancer. Science, 318, 463-467.
-
(2007)
Science
, vol.318
, pp. 463-467
-
-
Stites, E.C.1
-
40
-
-
44349096957
-
Pharmacogenomics of cardiovascular pharmacology: Pharmacogenomic network of cardiovascular disease models
-
Tanaka,T. et al. (2008) Pharmacogenomics of cardiovascular pharmacology: Pharmacogenomic network of cardiovascular disease models. J. Pharmacol. Sci., 107, 8-14.
-
(2008)
J. Pharmacol. Sci
, vol.107
, pp. 8-14
-
-
Tanaka, T.1
-
41
-
-
0036546455
-
Outcomes from peptic ulcer surgery have not benefited from advances in medical therapy
-
Towfigh,S. et al. (2002) Outcomes from peptic ulcer surgery have not benefited from advances in medical therapy. Am. Surg., 68 385-389.
-
(2002)
Am. Surg
, vol.68
, pp. 385-389
-
-
Towfigh, S.1
-
42
-
-
61349126118
-
Global versus local centrality in evolution of yeast protein network
-
Vinogradov,A.E. (2009) Global versus local centrality in evolution of yeast protein network. J. Mol. Evol., 68, 192-196.
-
(2009)
J. Mol. Evol
, vol.68
, pp. 192-196
-
-
Vinogradov, A.E.1
-
43
-
-
41949084159
-
Betweenness centrality in a weighted network
-
Wang,H. et al. (2008) Betweenness centrality in a weighted network. Phys Rev. E Stat. Nonlin. Soft Matter Phys, 77 (Pt 2), 046105.
-
(2008)
Phys Rev. E Stat. Nonlin. Soft Matter Phys
, vol.77
, Issue.PART 2
, pp. 046105
-
-
Wang, H.1
-
44
-
-
38549151817
-
DrugBank: A knowledgebase for drugs, drug actions and drug targets
-
Wishart,D.S. et al. (2008) DrugBank: A knowledgebase for drugs, drug actions and drug targets. Nucleic Acids Res., 36, D901-D906.
-
(2008)
Nucleic Acids Res
, vol.36
-
-
Wishart, D.S.1
-
45
-
-
0141484611
-
Evolutionary conservation of motif constituents in the yeast protein interaction network
-
Wuchty,S. et al. (2003) Evolutionary conservation of motif constituents in the yeast protein interaction network. Nat. Genet. 35, 176-179.
-
(2003)
Nat. Genet
, vol.35
, pp. 176-179
-
-
Wuchty, S.1
-
46
-
-
67049100457
-
-
Xie,L. et al. (2009) Drug discovery using chemical systems biology: Identification of the protein-ligand binding network to explain the side effects of cetp inhibitors. PLoS Comput. Biol., 5, e1000387.
-
Xie,L. et al. (2009) Drug discovery using chemical systems biology: Identification of the protein-ligand binding network to explain the side effects of cetp inhibitors. PLoS Comput. Biol., 5, e1000387.
-
-
-
-
47
-
-
34548862302
-
The mode-of-action by network identification (MNI) algorithm: A network biology approach for molecular target identification
-
Xing,H. and Gardner,T.S. (2006) The mode-of-action by network identification (MNI) algorithm: A network biology approach for molecular target identification. Nat. Protoc., 1, 2551-2554.
-
(2006)
Nat. Protoc
, vol.1
, pp. 2551-2554
-
-
Xing, H.1
Gardner, T.S.2
-
48
-
-
33645396484
-
Functional classification of drugs by properties of their pairwise interactions
-
Yeh,P. et al. (2006) Functional classification of drugs by properties of their pairwise interactions. Nat. Genet., 38, 489-494.
-
(2006)
Nat. Genet
, vol.38
, pp. 489-494
-
-
Yeh, P.1
-
49
-
-
35148838537
-
Drug-target network
-
Yildirim,M.A. et al. (2007) Drug-target network. Nat. Biotechnol., 25, 1119-1126.
-
(2007)
Nat. Biotechnol
, vol.25
, pp. 1119-1126
-
-
Yildirim, M.A.1
|