Identification of an adaptor-associated kinase, AAK1, as a regulator of clathrin-mediated endocytosis

Journal of Cell Biology

Volumn 156, Issue 5, 2002, Pages 921-929

  Conner, Sean D ^a   Schmid, Sandra L ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

AAK1; AP2; Clathrin; Endocytosis; Kinase

Indexed keywords

ADAPTOR ASSOCIATED KINASE 1; ADAPTOR PROTEIN; CLATHRIN; PHOSPHOTRANSFERASE; PROTEIN SERINE THREONINE KINASE; REGULATOR PROTEIN; TRANSCRIPTION FACTOR AP 2; TRANSFERRIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL MIGRATION; DEPHOSPHORYLATION; ENDOCYTOSIS; ENZYME ANALYSIS; ENZYME PHOSPHORYLATION; ENZYME PURIFICATION; INTERNALIZATION; NERVE ENDING; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN LOCALIZATION; REGULATORY MECHANISM;

ADAPTOR PROTEIN COMPLEX 2; ADAPTOR PROTEIN COMPLEX ALPHA SUBUNITS; ADAPTOR PROTEINS, VESICULAR TRANSPORT; AMINO ACID SEQUENCE; CARRIER PROTEINS; CELL MEMBRANE; CLATHRIN; CLONING, MOLECULAR; CYTOPLASMIC VESICLES; DNA, COMPLEMENTARY; ENDOCYTOSIS; HELA CELLS; HIPPOCAMPUS; HUMANS; MEMBRANE PROTEINS; MOLECULAR SEQUENCE DATA; PHOSPHORYLATION; PRESYNAPTIC TERMINALS; PROTEIN STRUCTURE, TERTIARY; PROTEIN-SERINE-THREONINE KINASES;

ANIMALIA;

EID: 0037018152     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.200108123     Document Type: Article

References (47)

1. Structural relationships between clathrin assembly proteins from the Golgi and the plasma membrane
2. Clathrin-coated vesicles contain two protein kinase activities. Phosphorylation of clathrin beta-light chain by casein kinase II
3. Amphiphysin I is associated with coated endocytic intermediates and undergoes stimulation-dependent dephosphorylation in nerve terminals
4. Clathrin structure characterized with monoclonal antibodies. I. Analysis of multiple antigenic sites
5. Multiple GTP-binding proteins participate in clathrin-coated vesicle-mediated endocytosis
6. The interaction of epsin and Eps15 with the clathrin adaptor AP-2 is inhibited by mitotic phosphorylation and enhanced by stimulation-dependent dephosphorylation in nerve terminals
7. 100-kDa polypeptides in peripheral clathrin-coated vesicles are required for receptor-mediated endocytosis
8. Novel protein kinases Ark1p and Prk1p associate with and regulate the cortical actin cytoskeleton in budding yeast
9. Protein phosphorylation is required for endocytosis in nerve terminals: Potential role for the dephosphins dynamin I and synaptojanin, but not AP180 or amphiphysin
10. Binding of AP2 to sorting signals is modulated by AP2 phosphorylation
11. Brain coated vesicle destabilization and phosphorylation of coat proteins
12. ATP- and cytosol-dependent release of adaptor proteins from clathrin-coated vesicles: A dual role for Hsc70
13. The phosphorylation of coated membrane proteins in intact neurons
14. Adaptors for clathrin-mediated traffic
15. Clathrin
16. Calcineurin inhibition of dynamin I GTPase activity coupled to nerve terminal depolarization
17. A novel role for Rab5-GDI in ligand sequestration into clathrincoated pits
18. A conserved clathrin assembly motif essential for synaptic vesicle endocyrosis
19. Analysis of 100-180-kDa phosphoproteins in clathrin-coated vesicles from bovine brain
20. Functional organization of clathrin in coats: Combining electron cryomicroscopy and x-ray crystallography
21. Folding and trimerization of clathrin subunits at the triskelion hub
22. Dominant-interfering hsc70 mutants disrupt multiple stages of the clathrin-coated vesicle cycle in vivo
23. Interaction of tyrosine-based sorting signals with clathrin-associated proteins
24. Structural determinants of interaction of tyrosine-based sorting signals with the adaptor medium chains
25. Phosphorylation of threonine 156 of the μ2 subunit of the AP2 complex is essential for endocytosis in vitro and in vivo
26. A structural explanation for the binding of multiple ligands by the alpha-adaptin appendage domain
27. Targeting signals and subunit interactions in coated vesicle adaptor complexes
28. Presence of cyclic nucleotide-Ca2+ independent protein kinase in bovine brain coated vesicles
29. The 50 kDa protein subunit of assembly polypepride (AP) AP-2 adaptor from clathrin-coated vesicles is phosphorylated on threonine-156 by AP-1 and a soluble AP50 kinase which co-purifies with the assembly polypeptides
30. Protein kinase(s) in bovine brain coated vesicles
31. Cyclic phosphorylation/dephosphorylation cascade in bovine brain coated vesicles
32. Regulatory interactions in the recognition of endocyric sorting signals by AP-2 complexes
33. Phosphorylation of the AP2 μ subunit by AAK1 mediates high affinity binding to the membrane protein sorting signals
34. Phosphorylation of dynamin I and synaptic-vesicle recycling
35. Binding specificity and in vivo targets of the EH domain, a novel protein-protein interaction module
36. Tissue specific expression of mouse alpha-amylase genes
37. Clathrin-coated vesicle formation and protein sorting: An integrated process
38. A clathrin-binding site in the hinge of the beta 2 chain of mammalian AP-2 complexes
39. Role of phosphorylation in regulation of the assembly of endocytic coat complexes
40. Cytosol- and clathrin-dependent stimulation of endocytosis in vitro by purified adaptors
41. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: Procedure and some applications
42. Protein phosphorylation and the regulation of synaptic membrane traffic
43. Dynamin GTPase is stimulated by crosslinking through the C-terminal proline-rich domain
44. Pan1p, yeast eps15, functions as a multivalent adaptor that coordinates protein-protein interactions essential for endocytosis
45. In vivo phosphorylation of adaptors regulates their interaction with clathrin
46. Regulation of the actin cyroskeleton organization in yeast by a novel serine/threonine kinase Prk1p