A kinome-Wide siRNA screen identifies multiple roles for protein kinases in hypoxic stress adaptation, including roles for IRAK4 and GAK in protection against apoptosis in VHL-/- Renal carcinoma cells, despite activation of the NF-κB pathway

Journal of Biomolecular Screening

Volumn 18, Issue 7, 2013, Pages 782-796

  Pan, Jing ^a   Zhang, Jing ^a   Hill, Andrew ^a   Lapan, Peter ^a   Berasi, Steve ^a   Bates, Brian ^a,b   Miller, Christopher ^a,c   Haney, Steven ^a,d  

^a PFIZER INC   (United States)

^b NeoBioLab   (United States)

^c BRISTOL MYERS SQUIBB   (United States)

^d ELI LILLY AND COMPANY   (United States)

Author keywords

cancer and cancer drugs; image analysis; phenotypic drug discovery; RNA interference; RNAi; shRNA

Indexed keywords

CYCLIN G ASSOCIATED KINASE; DUAL SPECIFICITY TYROSINE PHOSPHORYLATIONREGULATED KINASE 1B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INOSITOL HEXAKISPHOSPHATE KINASE 2; INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE 4; MEGAKARYOCYTE ASSOCIATED TYROSINE KINASE; PROTEIN IRE1; PROTEIN KINASE; PROTEIN TYROSINE KINASE; SHORT HAIRPIN RNA; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; VON HIPPEL LINDAU PROTEIN; X BOX BINDING PROTEIN 1;

ANOXIA; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CARCINOMA CELL; CELL DEATH; CELL GROWTH; CELL NUCLEUS; CELL PROTECTION; CELL STRESS; CELL SURVIVAL; COLON CANCER; CONTROLLED STUDY; DNA DAMAGE; ENDOPLASMIC RETICULUM STRESS; GENE SILENCING; GENETIC TRANSFECTION; GENOME; HYPOXIA; KIDNEY CARCINOMA; KINOME; MELANOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION; SPHEROID CELL;

EID: 84880815785     PISSN: 10870571     EISSN: 1552454X     Source Type: Journal    
DOI: 10.1177/1087057113484803     Document Type: Article

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