Phosphorylation of the AP2 μ subunit by AAK1 mediates high affinity binding to membrane protein sorting signals

Journal of Cell Biology

Volumn 156, Issue 5, 2002, Pages 791-795

  Ricotta, Doris ^a   Conner, Sean D ^b   Schmid, Sandra L ^b   Von Figura, Kurt ^a   Höning, Stefan ^a  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Clathrin; Coated vesicle; Endocytosis; Receptor; Trafficking

Indexed keywords

ADAPTOR PROTEIN; CLATHRIN; MEMBRANE PROTEIN; PHOSPHOTRANSFERASE; PROTEIN AAK1; PROTEIN SUBUNIT; THREONINE; TRANSCRIPTION FACTOR AP 2; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; DEPHOSPHORYLATION; ENDOCYTOSIS; IN VITRO STUDY; MOLECULAR RECOGNITION; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FOLDING; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

ADAPTOR PROTEIN COMPLEX 2; ADAPTOR PROTEINS, VESICULAR TRANSPORT; ANIMALS; BINDING SITES; CARRIER PROTEINS; CELL MEMBRANE; ENDOCYTOSIS; MEMBRANE PROTEINS; PHOSPHORYLATION; PROTEIN TRANSPORT; PROTEIN-SERINE-THREONINE KINASES; RECEPTORS, CELL SURFACE; SWINE;

EID: 0037018156     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.200111068     Document Type: Article

References (18)

1. Functional domain mapping of the clathrin-associated adaptor medium chains μ1 and μ2
2. Clathrin-coated vesicles contain two protein kinase activities. Phosphorylation of clathrin beta-light chain by casein kinase II
3. Identification of a protein kinase as an intrinsic component of rat liver coated vesicles
4. Identification of an adaptor-associated kinase, AAK1, as a regulator of clathrin-mediated endocytosis
5. The dephosphins: Dephosphorylation by calcineurin triggers synaptic vesicle endocytosis
6. Binding of AP2 to sorting signals is modulated by AP2 phosphorylation
7. The alpha chain of the AP-2 adaptor is a clathrin binding subunit
8. Role of cyclin G-associated kinase in uncoating clathrin-coated vesicles from nonneuronal cells
9. The 46-kDa mannose 6-phosphate receptor contains multiple binding sites for clathrin adaptors
10. Adaptors for clathrin-mediated traffic
11. Phosphorylation of threonine 156 of the μ2 subunit of the AP2 complex is essential for endocytosis in vitro and in vivo
12. A structural explanation for the recognition of tyrosine-based endocytotic signals
13. The 50 kDa protein subunit of assembly polypepride (AP) AP-2 adaptor from clathrin-coated vesicles is phosphorylated on rhreonine-156 by AP-1 and a soluble AP50 kinase which co-purifies with the assembly polypeptides
14. Protein kinase(s) in bovine brain coated vesicles
15. A clathrin-binding site in the hinge of the beta 2 chain of mammalian AP-2 complexes
16. Role of phosphorylation in regulation of the assembly of endocytic coat complexes
17. Identification of the universal cofactor (auxilin 2) in clathrin coat dissociation
18. In vivo phosphorylation of adaptors regulates their interaction with clathrin