Raf-1 sets the threshold of Fas sensitivity by modulating Rok-α signaling

Journal of Cell Biology

Volumn 171, Issue 6, 2005, Pages 1013-1022

  Piazzolla, Daniela ^a   Meissl, Katrin ^a   Kucerova, Lucia ^a   Rubiolo, Cristina ^b   Baccarini, Manuela ^a  

^a Vienna Biocenter   (Austria)

^b MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

EZRIN; FAS ANTIGEN; PROTEIN; PROTEIN KINASE; RAF PROTEIN; ROK ALPHA PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL DEATH; CONTROLLED STUDY; DEREGULATION; EMBRYO; FETUS; FETUS LIVER; FIBROBLAST; HYPERSENSITIVITY; LETHALITY; MEMBRANE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEFICIENCY; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; UPREGULATION;

ANIMALS; APOPTOSIS; CELLS, CULTURED; CYTOSKELETAL PROTEINS; DEATH DOMAIN RECEPTOR SIGNALING ADAPTOR PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; EMBRYONIC DEVELOPMENT; FIBROBLASTS; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE; GENES, LETHAL; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LIVER; MEMBRANES; MICE; MICE, MUTANT STRAINS; MODELS, BIOLOGICAL; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS C-RAF; RECEPTORS, TUMOR NECROSIS FACTOR; SENSITIVITY AND SPECIFICITY; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR RECEPTOR-ASSOCIATED PEPTIDES AND PROTEINS;

ANIMALIA;

EID: 29144512451     PISSN: 00219525     EISSN: 00219525     Source Type: Journal    
DOI: 10.1083/jcb.200504137     Document Type: Article

References (32)

1. Algeciras-Schimnich, A., L. Shen, B.C. Barnhart, A.E. Murmann, J.K. Burkhardt, and M.E. Peter. 2002. Molecular ordering of the initial signaling events of CD95. Mol. Cell. Biol. 22:207-220.
2. Baccarini, M. 2002. An old kinase on a new path: Raf and apoptosis. Cell Death Differ. 9:783-785.
3. Bentele, M., I. Lavrik, M. Ulrich, S. Stosser, D.W. Heermann, H. Kalthoff, P.H. Krammer, and R. Eils. 2004. Mathematical modeling reveals threshold mechanism in CD95-induced apoptosis. J. Cell Biol. 166:839-851.
4. Bretscher, A., K. Edwards, and R.G. Fehon. 2002. ERM proteins and merlin: integrators at the cell cortex. Nat. Rev. Mol. Cell Biol. 3:586-599.
5. Chang, D.W., Z. Xing, Y. Pan, A. Algeciras-Schimnich, B.C. Barnhart, S. Yaish-Ohad, M.E. Peter, and X. Yang. 2002. c-FLIP(L) is a dual function regulator for caspase-8 activation and CD95-mediated apoptosis. EMBO J. 21:3704-3714.
6. Chen, J., K. Fujii, L. Zhang, T. Roberts, and H. Fu. 2001. Raf-1 promotes cell survival by antagonizing apoptosis signal- regulating kinase 1 through a MEKERK independent mechanism. Proc. Natl. Acad. Sci. USA. 98:7783-7788.
7. Crepaldi, T., A. Gautreau, P.M. Comoglio, D. Louvard, and M. Arpin. 1997. Ezrin is an effector of hepatocyte growth factor-mediated migration and morphogenesis in epithelial cells. J. Cell Biol. 138:423-434.
8. De Maria, R., U. Testa, L. Luchetti, A. Zeuner, G. Stassi, E. Pelosi, R. Riccioni, N. Felli, P. Samoggia, and C. Peschle. 1999. Apoptotic role of Fas/Fas ligand system in the regulation of erythropoiesis. Blood. 93:796-803.
9. Ehrenreiter, K., D. Piazzolla, V. Velamoor, I. Sobczak, J.V. Small, J. Takeda, T. Leung, and M. Baccarini. 2005. Raf-1 regulates Rho signaling and cell migration. J. Cell Biol. 168:955-964.
10. Huser, M., J. Luckett, A. Chiloeches, K. Mercer, M. Iwobi, S. Giblett, X.M. Sun, J. Brown, R. Marais, and C. Pritchard. 2001. MEK kinase activity is not necessary for Raf-1 function. EMBO J. 20:1940-1951.
11. Kanzler, S., and P.R. Galle. 2000. Apoptosis and the liver. Semin. Cancer Biol. 10:173-184.
12. Kataoka, T., R.C. Budd, N. Holler, M. Thome, F. Martinon, M. Irmler, K. Burns, M. Hahne, N. Kennedy, M. Kovacsovics, and J. Tschopp. 2000. The caspase-8 inhibitor FLIP promotes activation of NF-κB and Erk signaling pathways. Curr. Biol. 10:640-648.
13. Kolbus, A., S. Pilat, Z. Husak, E.M. Deiner, G. Stengl, H. Beug, and M. Baccarini. 2002. Raf-1 antagonizes erythroid differentiation by restraining caspase activation. J. Exp. Med. 196:1347-1353.
14. Kondo, T., K. Takeuchi, Y. Doi, S. Yonemura, S. Nagata, and S. Tsukita. 1997. ERM (ezrin/radixin/moesin)-based molecular mechanism of microvillar breakdown at an early stage of apoptosis. J. Cell Biol. 139:749-758.
15. Lee, J.-H., T. Katakai, T. Hara, H. Gonda, M. Sugai, and A. Shimizu. 2004. Roles of p-ERM and Rho-ROCK signaling in lymphocyte polarity and uropod formation. J. Cell Biol. 167:327-337.
16. Lozupone, F., L. Lugini, P. Matarrese, F. Luciani, C. Federici, E. Iessi, P. Margutti, G. Stassi, W. Malorni, and S. Fais. 2004. Identification and relevance of the CD95-binding domain in the N-terminal region of ezrin. J. Biol. Chem. 279:9199-9207.
17. Micheau, O., S. Lens, O. Gaide, K. Alevizopoulos, and J. Tschopp. 2001. NF-kappaB signals induce the expression of c-FLIP. Mol. Cell. Biol. 21:5299-5305.
18. Micheau, O., M. Thome, P. Schneider, N. Holler, J. Tschopp, D.W. Nicholson, C. Briand, and M.G. Grutter. 2002. The long form of FLIP is an activator of caspase-8 at the Fas death- inducing signaling complex. J. Biol. Chem. 277:45162-45171.
19. Mikula, M., M. Schreiber, Z. Husak, L. Kucerova, J. Ruth, R. Wieser, K. Zatloukal, H. Beug, E.F. Wagner, and M. Baccarini. 2001. Embryonic lethality and fetal liver apoptosis in mice lacking the c-raf-1 gene. EMBO J. 20:1952-1962.
20. Mixter, P.F., J.Q. Russell, F.H. Durie, and R.C. Budd. 1995. Decreased CD4-CD8- TCR-alpha beta + cells in lpr/lpr mice lacking beta 2-microglobulin. J. Immunol. 154:2063-2074.
21. O'Neill, E., L. Rushworth, M. Baccarini, and W. Kolch. 2004. Role of the kinase MST2 in suppression of apoptosis by the proto-oncogene product Raf-1. Science. 306:2267-2270.
22. Parlato, S., A.M. Giammarioli, M. Logozzi, F. Lozupone, P. Matarrese, F. Luciani, M. Falchi, W. Malorni, and S. Fais. 2000. CD95 (APO-1/Fas) linkage to the actin cytoskeleton through ezrin in human T lymphocytes: a novel regulatory mechanism of the CD95 apoptotic pathway. EMBO J. 19:5123-5134.
23. Peter, M.E., and P.H. Krammer. 2003. The CD95(APO-1/Fas) DISC and beyond. Cell Death Differ. 10:26-35.
24. Schneider, E., G. Moreau, A. Arnould, F. Vasseur, N. Khodabaccus, M. Dy, and S. Ezine. 1999. Increased fetal and extramedullary hematopoiesis in Fas-deficient C57BL/6-lpr/lpr mice. Blood. 94:2613-2621.
25. Siegel, R.M., J.K. Frederiksen, D.A. Zacharias, F.K. Chan, M. Johnson, D. Lynch, R.Y. Tsien, and M.J. Lenardo. 2000. Fas preassociation required for apoptosis signaling and dominant inhibition by pathogenic mutations. Science. 288:2354-2357.
26. Takahashi, T., M. Tanaka, C.I. Brannan, N.A. Jenkins, N.G. Copeland, T. Suda, and S. Nagata. 1994. Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand. Cell. 76:969-976.
27. Takeuchi, K., N. Sato, H. Kasahara, N. Funayama, A. Nagafuchi, S. Yonemura, and S. Tsukita. 1994. Perturbation of cell adhesion and microvilli formation by antisense oligonucleotides to ERM family members. J. Cell Biol. 125:1371-1384.
28. Terada, T., and Y. Nakanuma. 1995. Detection of apoptosis and expression of apoptosis-related proteins during human intrahepatic bile duct development. Am. J. Pathol. 146:67-74.
29. Van Parijs, L., D.A. Peterson, and A.K. Abbas. 1998. The Fas/Fas ligand pathway and Bcl-2 regulate T cell responses to model self and foreign antigens. Immunity. 8:265-274.
30. Watanabe-Fukunaga, R., C.I. Brannan, N.G. Copeland, N.A. Jenkins, and S. Nagata. 1992. Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis. Nature. 356:314-317.
31. Yamaguchi, O., T. Watanabe, K. Nishida, K. Kashiwase, Y. Higuchi, T. Takeda, S. Hikoso, S. Hirotani, M. Asahi, M. Taniike, et al. 2004. Cardiac-specific disruption of the c-raf-1 gene induces cardiac dysfunction and apoptosis. J. Clin. Invest. 114:937-943.
32. Zhang, L., W. Wang, Y. Hayashi, J.V. Jester, D.E. Birk, M. Gao, C.-Y. Liu, W.W.-Y. Kao, M. Karin, and Y. Xia. 2003. A role for MEK kinase 1 in TGF-{beta}/activin-induced epithelium movement and embryonic eyelid closure. EMBO J. 22:4443-4454.