A robustness-based approach to systems-oriented drug design

Nature Reviews Drug Discovery

Volumn 6, Issue 3, 2007, Pages 202-210

  Kitano, Hiroaki ^a,b,c  

^a SONY COMPUTER SCIENCE LABORATORIES INC   (Japan)

^b Systems Biology Institute   (Japan)

^c CANCER INSTITUTE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

17 ALLYLAMINO 17 DEMETHOXYGELDANAMYCIN; 7 ETHYL 10 HYDROXYCAMPTOTHECIN; AMPHIREGULIN; BCR ABL PROTEIN; BUTYRIC ACID DERIVATIVE; CELECOXIB; CHOLERA TOXIN; CYCLOOXYGENASE 2; DRUG; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; FLAVOPIRIDOL; FLUOROURACIL; FLUTICASONE PROPIONATE PLUS SALMETEROL; FOLINIC ACID; GEFITINIB; GUANINE NUCLEOTIDE BINDING PROTEIN; HEAT SHOCK PROTEIN 90; IMATINIB; LAMIVUDINE PLUS ZIDOVUDINE; LOVASTATIN PLUS NICOTINIC ACID; OXALIPLATIN; PACLITAXEL; PROTEIN TYROSINE KINASE; ROFECOXIB; SUNITINIB; TRASTUZUMAB; UNCLASSIFIED DRUG; UNINDEXED DRUG; VIRSTATIN; VIRULENCE FACTOR;

ANTIBIOTIC RESISTANCE; ARTICLE; BIOENGINEERING; BLADDER CANCER; BREAST CANCER; CARDIOVASCULAR DISEASE; CELL ACTIVITY; CELL CYCLE ARREST; CHOLERA; CHRONIC MYELOID LEUKEMIA; CHRONOTHERAPY; CIRCADIAN RHYTHM; COLORECTAL CANCER; COMBINATION CHEMOTHERAPY; CYTOLOGY; DOSAGE SCHEDULE COMPARISON; DRUG DESIGN; DRUG EFFICACY; DRUG PROTEIN BINDING; DRUG RESEARCH; DRUG RESPONSE; DRUG TARGETING; ENZYME INHIBITION; GASTROINTESTINAL DISEASE; GENE MUTATION; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HYPERCHOLESTEROLEMIA; INHIBITION KINETICS; INTERSTITIAL LUNG DISEASE; LUNG NON SMALL CELL CANCER; MATHEMATICAL ANALYSIS; METABOLOMICS; MONOTHERAPY; NONHUMAN; NONLINEAR SYSTEM; OVARY CANCER; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN INTERACTION; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; SIGNAL TRANSDUCTION; STOMACH CANCER; SYSTEMS BIOLOGY; TREATMENT OUTCOME; UNSPECIFIED SIDE EFFECT; VIBRIO CHOLERAE;

ANIMALS; CELL PROLIFERATION; COMMUNICABLE DISEASES; DRUG DESIGN; HUMANS; MODELS, THEORETICAL; NEOPLASMS; PHARMACEUTICAL PREPARATIONS; SIGNAL TRANSDUCTION; TECHNOLOGY, PHARMACEUTICAL;

EID: 33847377573     PISSN: 14741776     EISSN: 14741784     Source Type: Journal    
DOI: 10.1038/nrd2195     Document Type: Article

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