메뉴 건너뛰기




Volumn 3, Issue 4, 2008, Pages

A test of highly optimized tolerance reveals fragile cell-cycle mechanisms are molecular targets in clinical cancer trials

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CYCLIN B; CYCLIN DEPENDENT KINASE 1; CYCLIN E; DNA; PROTEIN TYROSINE PHOSPHATASE;

EID: 44349133309     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0002016     Document Type: Article
Times cited : (13)

References (90)
  • 1
    • 0028124463 scopus 로고
    • The two-hybrid system: An assay for protein-protein interactions
    • Fields S, Sternglanz R (1994) The two-hybrid system: an assay for protein-protein interactions. Trends Genet 10: 282-292.
    • (1994) Trends Genet , vol.10 , pp. 282-292
    • Fields, S.1    Sternglanz, R.2
  • 2
    • 0033741141 scopus 로고    scopus 로고
    • High-throughput screening for protein-protein interactions using two-hybrid assay
    • Cagney G, Uetz P, Fields S (2000) High-throughput screening for protein-protein interactions using two-hybrid assay Methods. Enzymol 328: 3-14.
    • (2000) Methods. Enzymol , vol.328 , pp. 3-14
    • Cagney, G.1    Uetz, P.2    Fields, S.3
  • 4
    • 0037050026 scopus 로고    scopus 로고
    • Functional organization of the yeast protcome by systematic analysis of protein complexes
    • Gavin A, Bosche M, Krause R, Grandi P, Marzioch M, et al. (2002) Functional organization of the yeast protcome by systematic analysis of protein complexes. Nature 415: 141-147.
    • (2002) Nature , vol.415 , pp. 141-147
    • Gavin, A.1    Bosche, M.2    Krause, R.3    Grandi, P.4    Marzioch, M.5
  • 5
    • 0037174671 scopus 로고    scopus 로고
    • Transcriptional Regulatory Networks in Saccharomyces cerevisiae
    • Lee TI, Rinaldi NJ, Robert F, Odom DT, Bar-Joseph Z, et al. (2002) Transcriptional Regulatory Networks in Saccharomyces cerevisiae. Science 298: 799-804.
    • (2002) Science , vol.298 , pp. 799-804
    • Lee, T.I.1    Rinaldi, N.J.2    Robert, F.3    Odom, D.T.4    Bar-Joseph, Z.5
  • 6
    • 0036500834 scopus 로고    scopus 로고
    • Reverse Engineering of Biological Complexity
    • Csete ME, Doyle JC (2002) Reverse Engineering of Biological Complexity. Science 295: 1664-1669.
    • (2002) Science , vol.295 , pp. 1664-1669
    • Csete, M.E.1    Doyle, J.C.2
  • 7
    • 7644238181 scopus 로고    scopus 로고
    • Biological robustness
    • Kitano H (2004) Biological robustness. Nat Rev Genet 5: 826-837.
    • (2004) Nat Rev Genet , vol.5 , pp. 826-837
    • Kitano, H.1
  • 8
    • 4344670936 scopus 로고    scopus 로고
    • Bow ties, metabolism and disease
    • Csete M, Doyle J (2004) Bow ties, metabolism and disease. Trends Biotechnol 22: 446-450.
    • (2004) Trends Biotechnol , vol.22 , pp. 446-450
    • Csete, M.1    Doyle, J.2
  • 11
    • 2442488881 scopus 로고    scopus 로고
    • Spontaneous emergence of complex optimal networks through evolutionary adaptation
    • Venkatasubramanian V, Katare S, Patkar PR, Mu FP (2004) Spontaneous emergence of complex optimal networks through evolutionary adaptation. Comput Chem Eng 28: 1789-1798.
    • (2004) Comput Chem Eng , vol.28 , pp. 1789-1798
    • Venkatasubramanian, V.1    Katare, S.2    Patkar, P.R.3    Mu, F.P.4
  • 12
    • 33645049042 scopus 로고    scopus 로고
    • Evolutionary design on a budget: Robustness and optimality of bacteriophage T7
    • You L, Yin J (2006) Evolutionary design on a budget: robustness and optimality of bacteriophage T7. IEE Proc Sys Biol 153: 46-52.
    • (2006) IEE Proc Sys Biol , vol.153 , pp. 46-52
    • You, L.1    Yin, J.2
  • 14
    • 0029849620 scopus 로고    scopus 로고
    • Cancer Cell Cycles
    • Sheir GJ (1996) Cancer Cell Cycles. Science 274: 1672-1677.
    • (1996) Science , vol.274 , pp. 1672-1677
    • Sheir, G.J.1
  • 15
    • 1342265607 scopus 로고    scopus 로고
    • Experimental Design in Systems Biology, Based on Parameter Sensitivity Analysis Using a Monte Carlo Method: A Case Study for the TNFá-Mediated NF-â-Signal Transduction Pathway
    • Cho KH, Shin SY, Kolch W, Wolkenhauer O (2003) Experimental Design in Systems Biology, Based on Parameter Sensitivity Analysis Using a Monte Carlo Method: A Case Study for the TNFá-Mediated NF-â-Signal Transduction Pathway. Simul-Trans See Model Simul Int 79: 726-739.
    • (2003) Simul-Trans See Model Simul Int , vol.79 , pp. 726-739
    • Cho, K.H.1    Shin, S.Y.2    Kolch, W.3    Wolkenhauer, O.4
  • 16
    • 31144431501 scopus 로고    scopus 로고
    • Robustness properties of apoptosis models with respect to parameter variations and intrinsic noise
    • Eissing T, Allgöwer F, Ballinger E (2005) Robustness properties of apoptosis models with respect to parameter variations and intrinsic noise. IEE Proc Sys Biol 152: 221-228.
    • (2005) IEE Proc Sys Biol , vol.152 , pp. 221-228
    • Eissing, T.1    Allgöwer, F.2    Ballinger, E.3
  • 18
    • 34547570814 scopus 로고    scopus 로고
    • Sensitivity Analysis of Intracellular Signaling Pathway Kinetics Predicts Targets for Stem Cell Fate Control
    • Mahdavi A, Davey RE, Bhola P, Yin T, Zandstra PW (2007) Sensitivity Analysis of Intracellular Signaling Pathway Kinetics Predicts Targets for Stem Cell Fate Control. PLoS Comput Biol 3: 1257-1267.
    • (2007) PLoS Comput Biol , vol.3 , pp. 1257-1267
    • Mahdavi, A.1    Davey, R.E.2    Bhola, P.3    Yin, T.4    Zandstra, P.W.5
  • 19
    • 34547577428 scopus 로고    scopus 로고
    • Computationally Derived Points of Fragility of a Human Cascade we Consistent with Current Therapeutic Strategies
    • Luan D, Zai M, Varner J (2007) Computationally Derived Points of Fragility of a Human Cascade we Consistent with Current Therapeutic Strategies. PLOS Comput Biol 3: 1347-1359.
    • (2007) PLOS Comput Biol , vol.3 , pp. 1347-1359
    • Luan, D.1    Zai, M.2    Varner, J.3
  • 21
    • 4644301730 scopus 로고    scopus 로고
    • A Benchmark for Methods in Reverse Engineering and Model Discrimination: Problem Formulation and Solutions
    • Kremling A, Fischer S, Gadkar K, Doyle III FJ, Sauter T, et al. (2004) A Benchmark for Methods in Reverse Engineering and Model Discrimination: Problem Formulation and Solutions. Genome Res 14: 1773-1785.
    • (2004) Genome Res , vol.14 , pp. 1773-1785
    • Kremling, A.1    Fischer, S.2    Gadkar, K.3    Doyle III, F.J.4    Sauter, T.5
  • 22
    • 21644489637 scopus 로고    scopus 로고
    • Model identification of signal transduction networks from data using a state regulator problem
    • Gadkar KG, Varner J, Doyle III FJ (2005) Model identification of signal transduction networks from data using a state regulator problem. IEE Proc Syst Biol 2: 17-30.
    • (2005) IEE Proc Syst Biol , vol.2 , pp. 17-30
    • Gadkar, K.G.1    Varner, J.2    Doyle III, F.J.3
  • 23
    • 25444510601 scopus 로고    scopus 로고
    • Iterative approach to model identification of biological networks
    • Gadkar KG, Gunawan R, Doyle III FJ (2005) Iterative approach to model identification of biological networks. BMC Bioinformatics 6: 155-175.
    • (2005) BMC Bioinformatics , vol.6 , pp. 155-175
    • Gadkar, K.G.1    Gunawan, R.2    Doyle III, F.J.3
  • 25
    • 84986765250 scopus 로고
    • A computational algorithm for the Green's function method of sensitvity analysis in chemical kinetics
    • Dougherty EP, Rabitz H (1979) A computational algorithm for the Green's function method of sensitvity analysis in chemical kinetics. Int J Chem Kinet 11: 1237-1248.
    • (1979) Int J Chem Kinet , vol.11 , pp. 1237-1248
    • Dougherty, E.P.1    Rabitz, H.2
  • 26
    • 84985350684 scopus 로고
    • Sensitivity analysis in chemical kinetics: Recent developments and computational comparisons
    • Kramer MA, Rabit. H, Calo JM, Kee RJ (1984) Sensitivity analysis in chemical kinetics: Recent developments and computational comparisons. Int J Chem Kinet 16: 559-578.
    • (1984) Int J Chem Kinet , vol.16 , pp. 559-578
    • Kramer, M.A.1    Rabit, H.2    Calo, J.M.3    Kee, R.J.4
  • 27
    • 0021869852 scopus 로고
    • Sensitivity analysis of systems of differential and algebraic equations
    • Leis JR, Kramer MA (1985) Sensitivity analysis of systems of differential and algebraic equations. Comput Chem Eng 9: 93-96.
    • (1985) Comput Chem Eng , vol.9 , pp. 93-96
    • Leis, J.R.1    Kramer, M.A.2
  • 28
    • 22144498043 scopus 로고    scopus 로고
    • Sensitivity Analysis of Discrete Stochastic Systems
    • Gunawan R, Can Y, Petzold L, Doyle III FJ (2005) Sensitivity Analysis of Discrete Stochastic Systems. Biophys J 88: 2530-2540.
    • (2005) Biophys J , vol.88 , pp. 2530-2540
    • Gunawan, R.1    Can, Y.2    Petzold, L.3    Doyle III, F.J.4
  • 29
    • 33847377573 scopus 로고    scopus 로고
    • A robustness based approach to systems-oriented drug design
    • Kitano H (2007) A robustness based approach to systems-oriented drug design. Nat Rev Drug Discov 6: 202-210.
    • (2007) Nat Rev Drug Discov , vol.6 , pp. 202-210
    • Kitano, H.1
  • 30
    • 0033613221 scopus 로고    scopus 로고
    • A qualitative analysis of the kinetics of the G2 DNA damage checkpoint system
    • Aguda BD (1999) A qualitative analysis of the kinetics of the G2 DNA damage checkpoint system. Proc Natl Acad Sci U S A 96: 11352-11357.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 11352-11357
    • Aguda, B.D.1
  • 31
    • 0037302108 scopus 로고    scopus 로고
    • Regulation of the mammalian cell cycle: A model of the G1-to-S transition
    • Qu Z, Weiss JN, MacLellan WR (2003) Regulation of the mammalian cell cycle: a model of the G1-to-S transition. Am J Physiol-Cell Physiol 284: C349-C364.
    • (2003) Am J Physiol-Cell Physiol , vol.284
    • Qu, Z.1    Weiss, J.N.2    MacLellan, W.R.3
  • 32
    • 4444349425 scopus 로고    scopus 로고
    • A model for restriction point control of the mammalian cell cycle
    • Novak M, Tyson JJ (2004) A model for restriction point control of the mammalian cell cycle. J Theor Biol 230: 563-579.
    • (2004) J Theor Biol , vol.230 , pp. 563-579
    • Novak, M.1    Tyson, J.J.2
  • 33
    • 0033453231 scopus 로고    scopus 로고
    • The kinetic origins of the restriction point in the mammalian cell cycle
    • Aguda BD, Tang Y (1999) The kinetic origins of the restriction point in the mammalian cell cycle. Cell Proliferation 32: 321-335.
    • (1999) Cell Proliferation , vol.32 , pp. 321-335
    • Aguda, B.D.1    Tang, Y.2
  • 34
    • 0033529124 scopus 로고    scopus 로고
    • Instabilities in phosphorylation-dephosphorylation cascades and cell cycle checkpoints
    • Aguda BD (1999) Instabilities in phosphorylation-dephosphorylation cascades and cell cycle checkpoints. Oncogene 18: 2846-2851.
    • (1999) Oncogene , vol.18 , pp. 2846-2851
    • Aguda, B.D.1
  • 35
    • 34250865564 scopus 로고    scopus 로고
    • CDC25 phosphatases in cancer cells: Key players? Good targets?
    • Boutros R, Lobjois V, Ducommun B (2007) CDC25 phosphatases in cancer cells: key players? Good targets? Nat Rev Cancer 7: 495-507.
    • (2007) Nat Rev Cancer , vol.7 , pp. 495-507
    • Boutros, R.1    Lobjois, V.2    Ducommun, B.3
  • 36
    • 33746075605 scopus 로고    scopus 로고
    • PM-20, a novel inhibitor of Cdc25A, induces extracellular signal-regulated kinase 1/2 phosphorylation and inhibits hepatocellular carcinoma growth in vitro and in vivo
    • Kar S, Wang MF, Yao W, Michejda CJ, Carr BI (2006) PM-20, a novel inhibitor of Cdc25A, induces extracellular signal-regulated kinase 1/2 phosphorylation and inhibits hepatocellular carcinoma growth in vitro and in vivo. Mol Cancer Ther 5: 1511-1519.
    • (2006) Mol Cancer Ther , vol.5 , pp. 1511-1519
    • Kar, S.1    Wang, M.F.2    Yao, W.3    Michejda, C.J.4    Carr, B.I.5
  • 37
    • 27744539982 scopus 로고    scopus 로고
    • Inhibition of human tumor cell growth in vivo by an orally bioavailable inhibitor of CDC25 phosphatases
    • Brezak MC, Quaranta M, Contour-Galcera MO, Lavergne O, Mondesert O, et al. (2005) Inhibition of human tumor cell growth in vivo by an orally bioavailable inhibitor of CDC25 phosphatases. Mol Cancer Ther 4: 1378-1387.
    • (2005) Mol Cancer Ther , vol.4 , pp. 1378-1387
    • Brezak, M.C.1    Quaranta, M.2    Contour-Galcera, M.O.3    Lavergne, O.4    Mondesert, O.5
  • 38
    • 0034163387 scopus 로고    scopus 로고
    • Cdc25 Inhibition and Cell Cycle Arrest by a Synthetic Tbioalkyl Vitamin K Analogue 1
    • Tamura K, Southwick EC, Kerns J, Rosi K, Cart BI, et al. (2000) Cdc25 Inhibition and Cell Cycle Arrest by a Synthetic Tbioalkyl Vitamin K Analogue 1. Cancer Res 60: 1317-1325.
    • (2000) Cancer Res , vol.60 , pp. 1317-1325
    • Tamura, K.1    Southwick, E.C.2    Kerns, J.3    Rosi, K.4    Cart, B.I.5
  • 39
    • 33644830944 scopus 로고    scopus 로고
    • Targeting the Cell Cycle: A New Approach to Cancer Therapy
    • Schwartz GK, Shah MA (2005) Targeting the Cell Cycle: A New Approach to Cancer Therapy. J Clin Oncol 23: 9408-9421.
    • (2005) J Clin Oncol , vol.23 , pp. 9408-9421
    • Schwartz, G.K.1    Shah, M.A.2
  • 41
    • 0033375469 scopus 로고    scopus 로고
    • Flavopiridol: The First Cyclin-Dependent Kinase Inhibitor in Human Clinical Trials
    • Senderowicz AM (1999) Flavopiridol: the First Cyclin-Dependent Kinase Inhibitor in Human Clinical Trials. Invest New Drugs 17: 313-320.
    • (1999) Invest New Drugs , vol.17 , pp. 313-320
    • Senderowicz, A.M.1
  • 42
    • 47649097057 scopus 로고    scopus 로고
    • NCI (2007) A Phase II Study of Flavopiridol (HMR 1275; NSC 649890) in Patients With Previously Untreated Metastatic or Locally Advanced Soft Tissue Sarcoma (Trial NCT00005974).
    • NCI (2007) A Phase II Study of Flavopiridol (HMR 1275; NSC 649890) in Patients With Previously Untreated Metastatic or Locally Advanced Soft Tissue Sarcoma (Trial NCT00005974).
  • 43
    • 47649126930 scopus 로고    scopus 로고
    • NCI (2007) A Pilot Study of Flavopiridol Administered as a 30-Minute Bolus Followed by a 4-Hour Infusion in Lymphomas and Multiple Myeloma (Trial NCT00112723).
    • NCI (2007) A Pilot Study of Flavopiridol Administered as a 30-Minute Bolus Followed by a 4-Hour Infusion in Lymphomas and Multiple Myeloma (Trial NCT00112723).
  • 44
    • 47649100546 scopus 로고    scopus 로고
    • NCI (2007) A Phase I Study Of Herceptin/Flavopiridol In HER-2 Positive Metatatic Breast Cancer (Trial NCT00039455).
    • NCI (2007) A Phase I Study Of Herceptin/Flavopiridol In HER-2 Positive Metatatic Breast Cancer (Trial NCT00039455).
  • 45
    • 47649101095 scopus 로고    scopus 로고
    • NCI (2007) Flavopiridol Plus Cisplatin or Carboplatin in Treating Patients With Advanced Solid Tumors (Trial NCT00003690).
    • NCI (2007) Flavopiridol Plus Cisplatin or Carboplatin in Treating Patients With Advanced Solid Tumors (Trial NCT00003690).
  • 46
    • 47649095753 scopus 로고    scopus 로고
    • NCI Phase I Dose-Finding Study of E7070 in Combination With Irinotecan (Trial NCT00060567).
    • NCI Phase I Dose-Finding Study of E7070 in Combination With Irinotecan (Trial NCT00060567).
  • 47
    • 0036866878 scopus 로고    scopus 로고
    • E7070: A novel synthetic sulfonamide targeting the cell cycle progression for the treatment of cancer
    • Van Kesteren C, Bejnen JH, Schellens JHM (2002) E7070: a novel synthetic sulfonamide targeting the cell cycle progression for the treatment of cancer. Anti-Cancer Drugs 13: 989-997.
    • (2002) Anti-Cancer Drugs , vol.13 , pp. 989-997
    • Van Kesteren, C.1    Bejnen, J.H.2    Schellens, J.H.M.3
  • 48
    • 47649088037 scopus 로고    scopus 로고
    • NCI (2007) Phase II Clinical Evaluation of BRYOSTATIN 1 in Patients with Relaped Multiple Myeloma (Trial NCT00002907).
    • NCI (2007) Phase II Clinical Evaluation of BRYOSTATIN 1 in Patients with Relaped Multiple Myeloma (Trial NCT00002907).
  • 49
    • 0031982782 scopus 로고    scopus 로고
    • Phase I study of bryostatin I in patients with relapsed non-Hodgkin's lymphoma and chronic lymphocytic leukemia
    • Varterasian ML, Mohammad RM, Eilender DS, Hulburd K, Rodriguez DH, et al. (1998) Phase I study of bryostatin I in patients with relapsed non-Hodgkin's lymphoma and chronic lymphocytic leukemia. J Clin Oncol 16: 56-62.
    • (1998) J Clin Oncol , vol.16 , pp. 56-62
    • Varterasian, M.L.1    Mohammad, R.M.2    Eilender, D.S.3    Hulburd, K.4    Rodriguez, D.H.5
  • 50
    • 0026532012 scopus 로고
    • Preclinical evaluation of bryostatin-1 as an anticancer agent against several marine tumor cell lines: In vitro versus in vivo activity
    • Hornung RL, Pearson JW, Bechwith M, Longo DL (1992) Preclinical evaluation of bryostatin-1 as an anticancer agent against several marine tumor cell lines: in vitro versus in vivo activity. Cancer Res 52: 101-107.
    • (1992) Cancer Res , vol.52 , pp. 101-107
    • Hornung, R.L.1    Pearson, J.W.2    Bechwith, M.3    Longo, D.L.4
  • 51
    • 0029150243 scopus 로고
    • Inhibition of leukemic cell growth by the protein kinase C activator bryostatin 1 correlates with the dcphosphorylation of cyclin dependent kinase 2
    • Asiedu C, Biggs J, Lilly M, Kraft AS (1995) Inhibition of leukemic cell growth by the protein kinase C activator bryostatin 1 correlates with the dcphosphorylation of cyclin dependent kinase 2. Cancer Res 55: 3716-3720.
    • (1995) Cancer Res , vol.55 , pp. 3716-3720
    • Asiedu, C.1    Biggs, J.2    Lilly, M.3    Kraft, A.S.4
  • 52
    • 34250732910 scopus 로고    scopus 로고
    • Synergistic effect of AS101 and Bryostatin-1 on myeloid leukemia cell differentiation in vitro and in an animal model
    • Hayun M, Okun E, Hayun R, Gafter U, Albeck M, et al. (2007) Synergistic effect of AS101 and Bryostatin-1 on myeloid leukemia cell differentiation in vitro and in an animal model. Leukemia 21: 1504-1513.
    • (2007) Leukemia , vol.21 , pp. 1504-1513
    • Hayun, M.1    Okun, E.2    Hayun, R.3    Gafter, U.4    Albeck, M.5
  • 53
    • 13444259647 scopus 로고    scopus 로고
    • Regulation of cap-dependent translation by eIF4E inhibitory proteins
    • Richter JD, Sonenberg N (2005) Regulation of cap-dependent translation by eIF4E inhibitory proteins. Nature 433: 477-480.
    • (2005) Nature , vol.433 , pp. 477-480
    • Richter, J.D.1    Sonenberg, N.2
  • 54
    • 0030940199 scopus 로고    scopus 로고
    • Overexpression of eukaryotic initiation factor 4 E(eIF4E) in breast carcinoma
    • Li BDL, Liu L, Dawson M, De Benedetti A (1997) Overexpression of eukaryotic initiation factor 4 E(eIF4E) in breast carcinoma. Cancer 79: 2385-2390.
    • (1997) Cancer , vol.79 , pp. 2385-2390
    • Li, B.D.L.1    Liu, L.2    Dawson, M.3    De Benedetti, A.4
  • 55
    • 1342322966 scopus 로고    scopus 로고
    • Inhibition of puromycin-induced apoptosis in breast cancer cells by IGF-1 occurs simultaneously with increase protein synthesis
    • Soderlund G, Haarhaus M, Chisalita S, Arnqvist HJ (2004) Inhibition of puromycin-induced apoptosis in breast cancer cells by IGF-1 occurs simultaneously with increase protein synthesis. Neoplasma. 51: 1-11.
    • (2004) Neoplasma , vol.51 , pp. 1-11
    • Soderlund, G.1    Haarhaus, M.2    Chisalita, S.3    Arnqvist, H.J.4
  • 56
    • 2342559981 scopus 로고    scopus 로고
    • The TOR pathway: A target for cancer therapy
    • Bjornsti MA, Houghton PJ (2004) The TOR pathway: a target for cancer therapy. Nat Rev Cancer 4: 335-348.
    • (2004) Nat Rev Cancer , vol.4 , pp. 335-348
    • Bjornsti, M.A.1    Houghton, P.J.2
  • 58
    • 0021164348 scopus 로고
    • Activity of rapamycin (AY-22,989) against transplanted tumors
    • Eng CP, Sehgal SN, Vezina C (1984) Activity of rapamycin (AY-22,989) against transplanted tumors. J Antibiot 37: 1231-1237.
    • (1984) J Antibiot , vol.37 , pp. 1231-1237
    • Eng, C.P.1    Sehgal, S.N.2    Vezina, C.3
  • 59
    • 1542398693 scopus 로고    scopus 로고
    • Randomized Phase II Study of Multiple Dose Levels of CCI-779, a Novel Mammalian Target of Rapamycin Kinase Inhibitor, in Patients With Advanced Refractory Renal Cell Carcinoma
    • Atkins MB, Hidalgo M, Stadler WM, Logan TF, Dutcher JP, et al. (2004) Randomized Phase II Study of Multiple Dose Levels of CCI-779, a Novel Mammalian Target of Rapamycin Kinase Inhibitor, in Patients With Advanced Refractory Renal Cell Carcinoma. J Clin Oncol 22: 909-918.
    • (2004) J Clin Oncol , vol.22 , pp. 909-918
    • Atkins, M.B.1    Hidalgo, M.2    Stadler, W.M.3    Logan, T.F.4    Dutcher, J.P.5
  • 60
    • 14644426573 scopus 로고    scopus 로고
    • RA22 (R490A) is a recombinant immunotoxin with Increased Antitumor Activity without and increase in Animal Toxicity
    • Bang S, Nagata S, Onda. M, Kreitman RJ, Pastan I (2005) RA22 (R490A) is a recombinant immunotoxin with Increased Antitumor Activity without and increase in Animal Toxicity. Clin Cancer Res 11: 1545-1550.
    • (2005) Clin Cancer Res , vol.11 , pp. 1545-1550
    • Bang, S.1    Nagata, S.2    Onda, M.3    Kreitman, R.J.4    Pastan, I.5
  • 61
    • 0026089183 scopus 로고
    • Cyclin is degraded by the ubiquitin pathway
    • Glotzer M, Murray AW, Kirschner MW (1991) Cyclin is degraded by the ubiquitin pathway. Nature 349: 132-138.
    • (1991) Nature , vol.349 , pp. 132-138
    • Glotzer, M.1    Murray, A.W.2    Kirschner, M.W.3
  • 62
    • 33745674468 scopus 로고    scopus 로고
    • Drug discovery in the ubiquitin-proteasome system
    • Nalepa G, Rolfe M, Harper JW (2006) Drug discovery in the ubiquitin-proteasome system. Nat Rev Drug Discov 5: 596-613.
    • (2006) Nat Rev Drug Discov , vol.5 , pp. 596-613
    • Nalepa, G.1    Rolfe, M.2    Harper, J.W.3
  • 63
    • 33646345376 scopus 로고    scopus 로고
    • Ubiquitin ligases - cell-cycle control and cancer
    • Nakayama KI, Nakayama K (2006) Ubiquitin ligases - cell-cycle control and cancer. Nat Rev Cancer 6: 369-381.
    • (2006) Nat Rev Cancer , vol.6 , pp. 369-381
    • Nakayama, K.I.1    Nakayama, K.2
  • 64
    • 0021099710 scopus 로고
    • Components of ubiquitin-protein ligase system. Resolution, affinity purification, and role in protein breakdown
    • Hershko A, Heller H, Elias S, Ciechanover A (1983) Components of ubiquitin-protein ligase system. Resolution, affinity purification, and role in protein breakdown. J Biol Chem 258: 8206-8214.
    • (1983) J Biol Chem , vol.258 , pp. 8206-8214
    • Hershko, A.1    Heller, H.2    Elias, S.3    Ciechanover, A.4
  • 65
    • 0036713310 scopus 로고    scopus 로고
    • The anaphase promoting complex - Its not just for mitosis any more
    • Harper JW, Burton JL, Solomon MJ (2002) The anaphase promoting complex - Its not just for mitosis any more. Genes Dev 16: 2179-2206.
    • (2002) Genes Dev , vol.16 , pp. 2179-2206
    • Harper, J.W.1    Burton, J.L.2    Solomon, M.J.3
  • 66
    • 13244283007 scopus 로고    scopus 로고
    • The anaphase-promoting complex - a key factor in the regulation of cen-cycle
    • Castro A, Bernis C, Vigneron S, Labbe JC, Lorca T (2005) The anaphase-promoting complex - a key factor in the regulation of cen-cycle. Oncogene 24: 314-325.
    • (2005) Oncogene , vol.24 , pp. 314-325
    • Castro, A.1    Bernis, C.2    Vigneron, S.3    Labbe, J.C.4    Lorca, T.5
  • 67
    • 13744260574 scopus 로고    scopus 로고
    • Missing the Target - Ubiquitin Ligase Drugs Stall
    • Garber K (2005) Missing the Target - Ubiquitin Ligase Drugs Stall. J Natl Cancer Inst 97: 166-167.
    • (2005) J Natl Cancer Inst , vol.97 , pp. 166-167
    • Garber, K.1
  • 68
    • 10744221485 scopus 로고    scopus 로고
    • In Vivo Activation of the p53 Pathway by Smal I-Molecule Antagonists of MDM2
    • Vassilev LT, Vu BT, Graves B, Carvajal D, Podlaski F, et al. (2004) In Vivo Activation of the p53 Pathway by Smal I-Molecule Antagonists of MDM2. Science 303: 844-848.
    • (2004) Science , vol.303 , pp. 844-848
    • Vassilev, L.T.1    Vu, B.T.2    Graves, B.3    Carvajal, D.4    Podlaski, F.5
  • 69
    • 0026649165 scopus 로고
    • Formation and activation of a cyclin E-cdk2 complex during the GI phase of the human cell cycle
    • Koff A, Giordano A, Desai D, Yamashita K, Harper JW, et al. (1992) Formation and activation of a cyclin E-cdk2 complex during the GI phase of the human cell cycle. Science 257: 1689-1694.
    • (1992) Science , vol.257 , pp. 1689-1694
    • Koff, A.1    Giordano, A.2    Desai, D.3    Yamashita, K.4    Harper, J.W.5
  • 71
    • 0031008465 scopus 로고    scopus 로고
    • Cyclin E-induced S phase without activation of the pRb/E2F pathway
    • Lukas J, Herzinger T, Hansen K, Moroni MC, Resnitzky D, et al. (1997) Cyclin E-induced S phase without activation of the pRb/E2F pathway. Genes Dev 11: 1479-1492.
    • (1997) Genes Dev , vol.11 , pp. 1479-1492
    • Lukas, J.1    Herzinger, T.2    Hansen, K.3    Moroni, M.C.4    Resnitzky, D.5
  • 73
    • 0035726627 scopus 로고    scopus 로고
    • Tumor-specific proteolytic processing of cyclin E generates hyperactive lower-molecular-weight forms
    • Porter DC, Zhang N, Danes C, McGahren MJ, Harwell RM, et al. (2001) Tumor-specific proteolytic processing of cyclin E generates hyperactive lower-molecular-weight forms. Mol Cell Biol 21: 6254-6269.
    • (2001) Mol Cell Biol , vol.21 , pp. 6254-6269
    • Porter, D.C.1    Zhang, N.2    Danes, C.3    McGahren, M.J.4    Harwell, R.M.5
  • 75
    • 0041854279 scopus 로고    scopus 로고
    • Cycin-dependent kinase 2 is essential for meiosis but not for mitotic cell division in mice
    • Ortega S, Prieto I, Odajima J, Martin A, Dubus P, et al. (2003) Cycin-dependent kinase 2 is essential for meiosis but not for mitotic cell division in mice. Nature Genet 35: 25-31.
    • (2003) Nature Genet , vol.35 , pp. 25-31
    • Ortega, S.1    Prieto, I.2    Odajima, J.3    Martin, A.4    Dubus, P.5
  • 76
    • 0032521376 scopus 로고    scopus 로고
    • Elevated and Absent pRb Expression Is Associated with Bladder Cancer Progression and Has Cooperative Effects with p53
    • Cote RJ, Dunn MD, Chattejee SJ, Stein JP, Shi SR, et al. (1998) Elevated and Absent pRb Expression Is Associated with Bladder Cancer Progression and Has Cooperative Effects with p53. Cancer Res 58: 1090-1094.
    • (1998) Cancer Res , vol.58 , pp. 1090-1094
    • Cote, R.J.1    Dunn, M.D.2    Chattejee, S.J.3    Stein, J.P.4    Shi, S.R.5
  • 77
    • 0030053130 scopus 로고    scopus 로고
    • Deregulated expression of E2F family members induces S-phase entry and overcomes pl61NK4A-mediated growth suppression
    • Lukas J, Petersen BO, Holm K, Bartek J, Helin K (1996) Deregulated expression of E2F family members induces S-phase entry and overcomes pl61NK4A-mediated growth suppression. Mol Cell Biol 16: 1047-1057.
    • (1996) Mol Cell Biol , vol.16 , pp. 1047-1057
    • Lukas, J.1    Petersen, B.O.2    Holm, K.3    Bartek, J.4    Helin, K.5
  • 78
    • 1242294471 scopus 로고    scopus 로고
    • Expression of Cyclin E Renders Cyclin D-CDK4 Dispensable for Inactivation of the Retinoblastoma Tumor Suppressor Protein, Activation of E2F, and G1-S Phase Progression
    • Keenan SM, Lents NH, Baldassare JJ (2004) Expression of Cyclin E Renders Cyclin D-CDK4 Dispensable for Inactivation of the Retinoblastoma Tumor Suppressor Protein, Activation of E2F, and G1-S Phase Progression. J Biol Chem 279: 5387-5396.
    • (2004) J Biol Chem , vol.279 , pp. 5387-5396
    • Keenan, S.M.1    Lents, N.H.2    Baldassare, J.J.3
  • 79
    • 0030947356 scopus 로고    scopus 로고
    • High level expression of p27kip1 and cyclin D1 in some human breast cancer cells: Inverse correlation between the expression of p27kip1 and degree of malignancy in human breast and colorectal cancers
    • Fredersdorf S, Burns J, Milne AM, Packham G, Fallis L, et al. (1997) High level expression of p27kip1 and cyclin D1 in some human breast cancer cells: Inverse correlation between the expression of p27kip1 and degree of malignancy in human breast and colorectal cancers. Prot Natl Acad Sci U S A 94: 6380-6385.
    • (1997) Prot Natl Acad Sci U S A , vol.94 , pp. 6380-6385
    • Fredersdorf, S.1    Burns, J.2    Milne, A.M.3    Packham, G.4    Fallis, L.5
  • 80
    • 0031895560 scopus 로고    scopus 로고
    • Cyclin D1 and human neoplasia
    • Donnellan R, Chetty R (1998) Cyclin D1 and human neoplasia. J Clin Pathol 51: 1-7.
    • (1998) J Clin Pathol , vol.51 , pp. 1-7
    • Donnellan, R.1    Chetty, R.2
  • 81
    • 0029111934 scopus 로고
    • Cyclin D1 provides a link between development and oncogenesis in the retina and the breast
    • Sicinski P, Donaher JL, Parker SB, Li T, Fazeli A, et al. (1995) Cyclin D1 provides a link between development and oncogenesis in the retina and the breast. Cell 82: 621-630.
    • (1995) Cell , vol.82 , pp. 621-630
    • Sicinski, P.1    Donaher, J.L.2    Parker, S.B.3    Li, T.4    Fazeli, A.5
  • 83
    • 10544256183 scopus 로고    scopus 로고
    • Cyclin D2 is an FSH-responsive gene involved in gonadal cell proliferation and oncogenesis
    • Sicinski P, Donaher JL, Geng Y, Parker SB, Gardner H, et al. (1996) Cyclin D2 is an FSH-responsive gene involved in gonadal cell proliferation and oncogenesis. Nature 384: 470-474.
    • (1996) Nature , vol.384 , pp. 470-474
    • Sicinski, P.1    Donaher, J.L.2    Geng, Y.3    Parker, S.B.4    Gardner, H.5
  • 84
    • 4444307411 scopus 로고    scopus 로고
    • Mouse Development and Cell Proliferation in the Absence of D-Cyclins
    • Kozar K, Ciemerych MA, Rebel VI, Shigematsu H, Zagozdzon A, et al. (2004) Mouse Development and Cell Proliferation in the Absence of D-Cyclins. Cell 118: 477-491.
    • (2004) Cell , vol.118 , pp. 477-491
    • Kozar, K.1    Ciemerych, M.A.2    Rebel, V.I.3    Shigematsu, H.4    Zagozdzon, A.5
  • 85
    • 33748465152 scopus 로고    scopus 로고
    • Isochron-based Phase Response Analysis of Circadian Rhythms
    • Gunawan R, Doyle HI FJ (2006) Isochron-based Phase Response Analysis of Circadian Rhythms. Biophys J 91: 2131-2141.
    • (2006) Biophys J , vol.91 , pp. 2131-2141
    • Gunawan, R.1    Doyle2    HI, F.J.3
  • 86
    • 34147139858 scopus 로고    scopus 로고
    • Phase sensitivity analysis of circadian rhythm entrainment
    • Gunawan R, Doyle III FJ (2007) Phase sensitivity analysis of circadian rhythm entrainment. J Biol Rhythms 22: 180-194.
    • (2007) J Biol Rhythms , vol.22 , pp. 180-194
    • Gunawan, R.1    Doyle III, F.J.2
  • 87
    • 19744380776 scopus 로고    scopus 로고
    • Cardiovascular Events Associated with Rofecoxib in a Colorectal Adenoma Chemoprevention
    • Bresalier RS, Sandler RS, Quan H, Bolognese JA, Oxenius B, et al. (2005) Cardiovascular Events Associated with Rofecoxib in a Colorectal Adenoma Chemoprevention. Trial N Engl J Med 352: 1092-1102.
    • (2005) Trial N Engl J Med , vol.352 , pp. 1092-1102
    • Bresalier, R.S.1    Sandler, R.S.2    Quan, H.3    Bolognese, J.A.4    Oxenius, B.5
  • 89
    • 84870267223 scopus 로고
    • The generalization of students problem when several different population variances are involved
    • Welch BL (1947) The generalization of students problem when several different population variances are involved. Biometrika 34: 28-35.
    • (1947) Biometrika , vol.34 , pp. 28-35
    • Welch, B.L.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.