A synthetic lethal screen identifies FAT1 as an antagonist of caspase-8 in extrinsic apoptosis

EMBO Journal

Volumn 33, Issue 3, 2014, Pages 181-197

  Kranz, Dominique ^a   Boutros, Michael ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Apoptosis; FAT1; Glioblastoma; TRAIL

Indexed keywords

CADHERIN; CADHERIN FAT1; CASPASE 8; DEATH DOMAIN RECEPTOR SIGNALING ADAPTOR PROTEIN; DEATH RECEPTOR; PROCASPASE 8; SMALL INTERFERING RNA; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; CRISPR CAS SYSTEM; ENZYME INHIBITION; ENZYME LOCALIZATION; ENZYME REGULATION; ENZYME SYNTHESIS; EXTRINSIC APOPTOSIS; GENE INACTIVATION; GENE SILENCING; GLIOBLASTOMA; GLIOMA CELL; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION;

APOPTOSIS; CADHERINS; CASPASE 8; CASPASE INHIBITORS; CELL LINE, TUMOR; CELL SURVIVAL; DEATH DOMAIN RECEPTOR SIGNALING ADAPTOR PROTEINS; ENZYME ACTIVATION; GENE KNOCKDOWN TECHNIQUES; GENOME-WIDE ASSOCIATION STUDY; HUMANS; IMMUNOPRECIPITATION; LIGANDS; MODELS, MOLECULAR; RECEPTORS, DEATH DOMAIN; RNA, SMALL INTERFERING; SEQUENCE ALIGNMENT; SEQUENCE ANALYSIS, DNA; SIGNAL TRANSDUCTION; TNF-RELATED APOPTOSIS-INDUCING LIGAND;

EID: 84897840443     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.1002/embj.201385686     Document Type: Article

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