-
1
-
-
53849092685
-
Will all Americans become overweight or obese? Estimating the progression and cost of the US obesity epidemic
-
Wang, Y., Beydoun, M. A., Liang, L., Caballero, B. & Kumanyika, S. K. Will all Americans become overweight or obese? Estimating the progression and cost of the US obesity epidemic. Obesity (Silver Spring) 16, 2323-2330 (2008).
-
(2008)
Obesity (Silver Spring)
, vol.16
, pp. 2323-2330
-
-
Wang, Y.1
Beydoun, M.A.2
Liang, L.3
Caballero, B.4
Kumanyika, S.K.5
-
2
-
-
51849146897
-
Global burden of obesity in 2005 and projections to 2030
-
Kelly, T., Yang, W., Chen, C. S., Reynolds, K. & He, J. Global burden of obesity in 2005 and projections to 2030. Int. J. Obes. (Lond.) 32, 1431-1437 (2008).
-
(2008)
Int. J. Obes. (Lond.)
, vol.32
, pp. 1431-1437
-
-
Kelly, T.1
Yang, W.2
Chen, C.S.3
Reynolds, K.4
He, J.5
-
3
-
-
34250155983
-
Increases in morbid obesity in the USA: 2000-2005
-
Sturm, R. Increases in morbid obesity in the USA: 2000-2005. Public Health 121, 492-496 (2007).
-
(2007)
Public Health
, vol.121
, pp. 492-496
-
-
Sturm, R.1
-
4
-
-
33645523067
-
Prevalence of overweight and obesity in the United States, 1999-2004
-
Ogden, C. L. et al. Prevalence of overweight and obesity in the United States, 1999-2004. JAMA 295, 1549-1555 (2006).
-
(2006)
JAMA
, vol.295
, pp. 1549-1555
-
-
Ogden, C.L.1
-
5
-
-
0036512243
-
The effects of obesity, smoking, and drinking on medical problems and costs
-
Sturm, R. The effects of obesity, smoking, and drinking on medical problems and costs. Health Aff. (Millwood) 21, 245-253 (2002).
-
(2002)
Health Aff. (Millwood)
, vol.21
, pp. 245-253
-
-
Sturm, R.1
-
6
-
-
0022589555
-
A twin study of human obesity
-
The first twin study of obesity that reported the substantial role of genetics
-
Stunkard, A. J., Foch, T. T. & Hrubec, Z. A twin study of human obesity. JAMA 256, 51-54 (1986). The first twin study of obesity that reported the substantial role of genetics.
-
(1986)
JAMA
, vol.256
, pp. 51-54
-
-
Stunkard, A.J.1
Foch, T.T.2
Hrubec, Z.3
-
7
-
-
0022657870
-
An adoption study of human obesity
-
Stunkard, A. J. et al. An adoption study of human obesity. N. Engl. J. Med. 314, 193-198 (1986).
-
(1986)
N. Engl. J. Med
, vol.314
, pp. 193-198
-
-
Stunkard, A.J.1
-
8
-
-
0025061375
-
Body weight in the Finnish Twin Cohort
-
Turula, M., Kaprio, J., Rissanen, A. & Koskenvuo, M. Body weight in the Finnish Twin Cohort. Diabetes Res. Clin. Pract. 10 (Suppl. 1), S33-S36 (1990).
-
(1990)
Diabetes Res. Clin. Pract
, vol.10
, Issue.SUPPL. 1
-
-
Turula, M.1
Kaprio, J.2
Rissanen, A.3
Koskenvuo, M.4
-
9
-
-
38949187953
-
-
Wardle, J., Carnell, S., Haworth, C. M. & Plomin, R. Evidence for a strong genetic influence on childhood adiposity despite the force of the obesogenic environment. Am. J. Clin. Nutr. 87, 398-404 (2008). A twin study showing that, even in an obesogenic environment, genetics has a significant effect on obesity.
-
Wardle, J., Carnell, S., Haworth, C. M. & Plomin, R. Evidence for a strong genetic influence on childhood adiposity despite the force of the obesogenic environment. Am. J. Clin. Nutr. 87, 398-404 (2008). A twin study showing that, even in an obesogenic environment, genetics has a significant effect on obesity.
-
-
-
-
10
-
-
33748031741
-
Regional admixture mapping and structured association testing: Conceptual unification and an extensible general linear model
-
Redden, D. T. et al. Regional admixture mapping and structured association testing: conceptual unification and an extensible general linear model. PLoS Genet. 2, e137 (2006).
-
(2006)
PLoS Genet
, vol.2
-
-
Redden, D.T.1
-
11
-
-
0033925030
-
Individual estimates of European genetic admixture associated with lower body-mass index, plasma glucose, and prevalence of type 2 diabetes in Pima Indians
-
Williams, R. C., Long, J. C., Hanson, R. L., Sievers, M. L. & Knowler, W. C. Individual estimates of European genetic admixture associated with lower body-mass index, plasma glucose, and prevalence of type 2 diabetes in Pima Indians. Am. J. Hum. Genet. 66, 527-538 (2000).
-
(2000)
Am. J. Hum. Genet
, vol.66
, pp. 527-538
-
-
Williams, R.C.1
Long, J.C.2
Hanson, R.L.3
Sievers, M.L.4
Knowler, W.C.5
-
12
-
-
0032980686
-
Fasting and leptin modulate adipose and muscle uncoupling protein: Divergent effects between messenger ribonucleic acid and protein expression
-
Sivitz, W. I., Fink, B. D. & Donohoue, P. A. Fasting and leptin modulate adipose and muscle uncoupling protein: divergent effects between messenger ribonucleic acid and protein expression. Endocrinology 140, 1511-1519 (1999).
-
(1999)
Endocrinology
, vol.140
, pp. 1511-1519
-
-
Sivitz, W.I.1
Fink, B.D.2
Donohoue, P.A.3
-
13
-
-
33847058514
-
Hypothalamic arcuate nucleus mediates the sympathetic and arterial pressure responses to leptin
-
Rahmouni, K. & Morgan, D. A. Hypothalamic arcuate nucleus mediates the sympathetic and arterial pressure responses to leptin. Hypertension 49, 647-652 (2007).
-
(2007)
Hypertension
, vol.49
, pp. 647-652
-
-
Rahmouni, K.1
Morgan, D.A.2
-
14
-
-
0027731309
-
Development of obesity in transgenic mice after genetic ablation of brown adipose tissue
-
The first report to show that loss of BAT in transgenic mice leads to obesity
-
Lowell, B. B. et al. Development of obesity in transgenic mice after genetic ablation of brown adipose tissue. Nature 366, 740-742 (1993). The first report to show that loss of BAT in transgenic mice leads to obesity.
-
(1993)
Nature
, vol.366
, pp. 740-742
-
-
Lowell, B.B.1
-
17
-
-
64349095231
-
Cold-activated brown adipose tissue in healthy men
-
van Marken Lichtenbelt, W. D. et al. Cold-activated brown adipose tissue in healthy men. N. Engl. J. Med. 360, 1500-1508 (2009).
-
(2009)
N. Engl. J. Med
, vol.360
, pp. 1500-1508
-
-
van Marken Lichtenbelt, W.D.1
-
18
-
-
64349105205
-
Identification and importance of brown adipose tissue in adult humans
-
Cypess, A. M. et al. Identification and importance of brown adipose tissue in adult humans. N. Engl. J. Med. 360, 1509-1517 (2009).
-
(2009)
N. Engl. J. Med
, vol.360
, pp. 1509-1517
-
-
Cypess, A.M.1
-
19
-
-
64349123664
-
Functional brown adipose tissue in healthy adults
-
Virtanen, K. A. et al. Functional brown adipose tissue in healthy adults. N. Engl. J. Med. 360, 1518-1525 (2009).
-
(2009)
N. Engl. J. Med
, vol.360
, pp. 1518-1525
-
-
Virtanen, K.A.1
-
20
-
-
0033304576
-
Human leptin deficiency caused by a missense mutation: Multiple endocrine defects, decreased sympathetic tone, and immune system dysfunction indicate new targets for leptin action, greater central than peripheral resistance to the effects of leptin, and spontaneous correction of leptin-mediated defects
-
Ozata, M., Ozdemir, I. C. & Licinio, J. Human leptin deficiency caused by a missense mutation: multiple endocrine defects, decreased sympathetic tone, and immune system dysfunction indicate new targets for leptin action, greater central than peripheral resistance to the effects of leptin, and spontaneous correction of leptin-mediated defects. J. Clin. Endocrinol. Metab. 84, 3686-3695 (1999).
-
(1999)
J. Clin. Endocrinol. Metab
, vol.84
, pp. 3686-3695
-
-
Ozata, M.1
Ozdemir, I.C.2
Licinio, J.3
-
21
-
-
41549165727
-
Profiling postprandial thermogenesis in muscle and fat of sheep and the central effect of leptin administration
-
Henry, B. A., Dunshea, F. R., Gould, M. & Clarke, I. J. Profiling postprandial thermogenesis in muscle and fat of sheep and the central effect of leptin administration. Endocrinology 149, 2019-2026 (2008).
-
(2008)
Endocrinology
, vol.149
, pp. 2019-2026
-
-
Henry, B.A.1
Dunshea, F.R.2
Gould, M.3
Clarke, I.J.4
-
22
-
-
50049122271
-
PRDM16 controls a brown fat/skeletal muscle switch
-
Seale, P. et al. PRDM16 controls a brown fat/skeletal muscle switch. Nature 454, 961-967 (2008).
-
(2008)
Nature
, vol.454
, pp. 961-967
-
-
Seale, P.1
-
23
-
-
50049127055
-
New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure
-
Tseng, Y. H. et al. New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure. Nature 454, 1000-1004 (2008).
-
(2008)
Nature
, vol.454
, pp. 1000-1004
-
-
Tseng, Y.H.1
-
24
-
-
44849132591
-
Dynamics of fat cell turnover in humans
-
Spalding, K. L. et al. Dynamics of fat cell turnover in humans. Nature 453, 783-787 (2008).
-
(2008)
Nature
, vol.453
, pp. 783-787
-
-
Spalding, K.L.1
-
25
-
-
34248136950
-
Childhood overweight and family income
-
Freedman, D. S. et al. Childhood overweight and family income. MedGenMed 9, 26 (2007).
-
(2007)
MedGenMed
, vol.9
, pp. 26
-
-
Freedman, D.S.1
-
26
-
-
27744585941
-
Long-term prospective and controlled studies demonstrate adipose tissue hypercellularity and relative leptin deficiency in the postobese state
-
Lofgren, P. et al. Long-term prospective and controlled studies demonstrate adipose tissue hypercellularity and relative leptin deficiency in the postobese state. J. Clin. Endocrinol. Metab. 90, 6207-6213 (2005).
-
(2005)
J. Clin. Endocrinol. Metab
, vol.90
, pp. 6207-6213
-
-
Lofgren, P.1
-
27
-
-
58149359144
-
Human obesity: A heritable neurobehavioral disorder that is highly sensitive to environmental conditions
-
O'Rahilly, S. & Farooqi, I. S. Human obesity: a heritable neurobehavioral disorder that is highly sensitive to environmental conditions. Diabetes 57, 2905-2910 (2008).
-
(2008)
Diabetes
, vol.57
, pp. 2905-2910
-
-
O'Rahilly, S.1
Farooqi, I.S.2
-
28
-
-
0028139089
-
Positional cloning of the mouse obese gene and its human homologue
-
The paper that identified the first gene underlying obesity and that brought obesity research into the modern age
-
Zhang, Y. et al. Positional cloning of the mouse obese gene and its human homologue. Nature 372, 425-432 (1994). The paper that identified the first gene underlying obesity and that brought obesity research into the modern age.
-
(1994)
Nature
, vol.372
, pp. 425-432
-
-
Zhang, Y.1
-
29
-
-
0030878110
-
Congenital leptin deficiency is associated with severe early-onset obesity in humans
-
The first reported evidence that monogenic obesity exists in humans
-
Montague, C. T. et al. Congenital leptin deficiency is associated with severe early-onset obesity in humans. Nature 387, 903-908 (1997). The first reported evidence that monogenic obesity exists in humans.
-
(1997)
Nature
, vol.387
, pp. 903-908
-
-
Montague, C.T.1
-
30
-
-
0344450708
-
A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction
-
Clement, K. et al. A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction. Nature 392, 398-401 (1998).
-
(1998)
Nature
, vol.392
, pp. 398-401
-
-
Clement, K.1
-
31
-
-
0031838353
-
Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans
-
Krude, H. et al. Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans. Nature Genet. 19, 155-157 (1998).
-
(1998)
Nature Genet
, vol.19
, pp. 155-157
-
-
Krude, H.1
-
32
-
-
0030949271
-
Obesity and impaired prohormone processing associated with mutations in the human prohormone convertase 1 gene
-
Jackson, R. S. et al. Obesity and impaired prohormone processing associated with mutations in the human prohormone convertase 1 gene. Nature Genet. 16, 303-306 (1997).
-
(1997)
Nature Genet
, vol.16
, pp. 303-306
-
-
Jackson, R.S.1
-
33
-
-
0031662163
-
-
Vaisse, C., Clement, K., Guy-Grand, B. & Froguel, P. A frameshift mutation in human MC4R is associated with a dominant form of obesity. Nature Genet. 20, 113-4 (1998). This paper, together with reference 34, first identified MC4R gene variants as the most prevalent form of monogenic human obesity.
-
Vaisse, C., Clement, K., Guy-Grand, B. & Froguel, P. A frameshift mutation in human MC4R is associated with a dominant form of obesity. Nature Genet. 20, 113-4 (1998). This paper, together with reference 34, first identified MC4R gene variants as the most prevalent form of monogenic human obesity.
-
-
-
-
34
-
-
0031668219
-
A frameshift mutation in MC4R associated with dominantly inherited human obesity
-
Yeo, G. S. et al. A frameshift mutation in MC4R associated with dominantly inherited human obesity. Nature Genet. 20, 111-112 (1998).
-
(1998)
Nature Genet
, vol.20
, pp. 111-112
-
-
Yeo, G.S.1
-
35
-
-
0034016043
-
Profound obesity associated with a balanced translocation that disrupts the SIM1 gene
-
Holder, J. L. Jr, Butte, N. F. & Zinn, A. R. Profound obesity associated with a balanced translocation that disrupts the SIM1 gene. Hum. Mol. Genet. 9, 101-108 (2000).
-
(2000)
Hum. Mol. Genet
, vol.9
, pp. 101-108
-
-
Holder Jr, J.L.1
Butte, N.F.2
Zinn, A.R.3
-
36
-
-
19944429689
-
Mutation screen of the brain derived neurotrophic factor gene (BDNF): Identification of several genetic variants and association studies in patients with obesity, eating disorders, and attention-deficit/hyperactivity disorder
-
Friedel, S. et al. Mutation screen of the brain derived neurotrophic factor gene (BDNF): identification of several genetic variants and association studies in patients with obesity, eating disorders, and attention-deficit/hyperactivity disorder. Am. J. Med. Genet. B Neuropsychiatr. Genet. 132B, 196-199 (2005).
-
(2005)
Am. J. Med. Genet. B Neuropsychiatr. Genet
, vol.132 B
, pp. 196-199
-
-
Friedel, S.1
-
37
-
-
7044262828
-
A de novo mutation affecting human TrkB associated with severe obesity and developmental delay
-
Yeo, G. S. et al. A de novo mutation affecting human TrkB associated with severe obesity and developmental delay. Nature Neurosci. 7, 1187-1189 (2004).
-
(2004)
Nature Neurosci
, vol.7
, pp. 1187-1189
-
-
Yeo, G.S.1
-
38
-
-
33749017409
-
The human obesity gene map: The 2005 update
-
Rankinen, T. et al. The human obesity gene map: the 2005 update. Obesity (Silver Spring) 14, 529-644 (2006).
-
(2006)
Obesity (Silver Spring)
, vol.14
, pp. 529-644
-
-
Rankinen, T.1
-
39
-
-
2642512097
-
GAD2 on chromosome 10p12 is a candidate gene for human obesity
-
Boutin, P. et al. GAD2 on chromosome 10p12 is a candidate gene for human obesity. PLoS Biol. 1, E68 (2003).
-
(2003)
PLoS Biol
, vol.1
-
-
Boutin, P.1
-
40
-
-
23044493861
-
Variants of ENPP1 are associated with childhood and adult obesity and increase the risk of glucose intolerance and type 2 diabetes
-
Meyre, D. et al. Variants of ENPP1 are associated with childhood and adult obesity and increase the risk of glucose intolerance and type 2 diabetes. Nature Genet. 37, 863-867 (2005).
-
(2005)
Nature Genet
, vol.37
, pp. 863-867
-
-
Meyre, D.1
-
41
-
-
0347354997
-
The SLC6A14 gene shows evidence of association with obesity
-
Suviolahti, E. et al. The SLC6A14 gene shows evidence of association with obesity. J. Clin. Invest. 112, 1762-72 (2003).
-
(2003)
J. Clin. Invest
, vol.112
, pp. 1762-1772
-
-
Suviolahti, E.1
-
42
-
-
4344651581
-
Polymorphisms in the amino acid transporter solute carrier family 6 (neurotransmitter transporter) member 14 gene contribute to polygenic obesity in French Caucasians
-
Durand, E. et al. Polymorphisms in the amino acid transporter solute carrier family 6 (neurotransmitter transporter) member 14 gene contribute to polygenic obesity in French Caucasians. Diabetes 53, 2483-2486 (2004).
-
(2004)
Diabetes
, vol.53
, pp. 2483-2486
-
-
Durand, E.1
-
43
-
-
35548952185
-
Meta-analysis of genome-wide linkage studies in BMI and obesity
-
Saunders, C. L. et al. Meta-analysis of genome-wide linkage studies in BMI and obesity. Obesity (Silver Spring) 15, 2263-2275 (2007).
-
(2007)
Obesity (Silver Spring)
, vol.15
, pp. 2263-2275
-
-
Saunders, C.L.1
-
44
-
-
34248594090
-
A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity
-
The first obesity gene identified through a GWA study, although the study was for type 2 diabetes rather than obesity
-
Frayling, T. M. et al. A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science 316, 889-894 (2007). The first obesity gene identified through a GWA study, although the study was for type 2 diabetes rather than obesity.
-
(2007)
Science
, vol.316
, pp. 889-894
-
-
Frayling, T.M.1
-
45
-
-
14344266748
-
The genetics of human obesity
-
Bell, C. G., Walley, A. J. & Froguel, P. The genetics of human obesity. Nature Rev. Genet. 6, 221-34 (2005).
-
(2005)
Nature Rev. Genet
, vol.6
, pp. 221-234
-
-
Bell, C.G.1
Walley, A.J.2
Froguel, P.3
-
46
-
-
3242725813
-
Common variants in the 5′ region of the leptin gene are associated with body mass index in men from the National Heart, Lung, and Blood Institute Family Heart Study
-
Jiang, Y. et al. Common variants in the 5′ region of the leptin gene are associated with body mass index in men from the National Heart, Lung, and Blood Institute Family Heart Study. Am. J. Hum. Genet. 75, 220-230 (2004).
-
(2004)
Am. J. Hum. Genet
, vol.75
, pp. 220-230
-
-
Jiang, Y.1
-
47
-
-
0032871802
-
Sequence variants in the 5′ flanking region of the leptin gene are associated with obesity in women
-
Li, W. D. et al. Sequence variants in the 5′ flanking region of the leptin gene are associated with obesity in women. Ann. Hum. Genet. 63, 227-234 (1999).
-
(1999)
Ann. Hum. Genet
, vol.63
, pp. 227-234
-
-
Li, W.D.1
-
48
-
-
17744381149
-
Associations between the leptin receptor gene and adiposity in middle-aged Caucasian males from the HERITAGE family study
-
Chagnon, Y. C. et al. Associations between the leptin receptor gene and adiposity in middle-aged Caucasian males from the HERITAGE family study. J. Clin. Endocrinol. Metab. 85, 29-34 (2000).
-
(2000)
J. Clin. Endocrinol. Metab
, vol.85
, pp. 29-34
-
-
Chagnon, Y.C.1
-
49
-
-
0031767007
-
Transmission disequilibrium and sequence variants at the leptin receptor gene in extremely obese German children and adolescents
-
Roth, H. et al. Transmission disequilibrium and sequence variants at the leptin receptor gene in extremely obese German children and adolescents. Hum. Genet. 103, 540-546 (1998).
-
(1998)
Hum. Genet
, vol.103
, pp. 540-546
-
-
Roth, H.1
-
50
-
-
48349084217
-
Leptin gene and leptin receptor gene polymorphisms are associated with sweet preference and obesity
-
Mizuta, E. et al. Leptin gene and leptin receptor gene polymorphisms are associated with sweet preference and obesity. Hypertens. Res. 31, 1069-1077 (2008).
-
(2008)
Hypertens. Res
, vol.31
, pp. 1069-1077
-
-
Mizuta, E.1
-
51
-
-
0037101841
-
A missense mutation disrupting a dibasic prohormone processing site in proopiomelanocortin (POMC) increases susceptibility to early-onset obesity through a novel molecular mechanism
-
Challis, B. G. et al. A missense mutation disrupting a dibasic prohormone processing site in proopiomelanocortin (POMC) increases susceptibility to early-onset obesity through a novel molecular mechanism. Hum. Mol. Genet. 11, 1997-2004 (2002).
-
(2002)
Hum. Mol. Genet
, vol.11
, pp. 1997-2004
-
-
Challis, B.G.1
-
52
-
-
48349113289
-
Common nonsynonymous variants in PCSK1 confer risk of obesity
-
Benzinou, M. et al. Common nonsynonymous variants in PCSK1 confer risk of obesity. Nature Genet. 40, 943-945 (2008).
-
(2008)
Nature Genet
, vol.40
, pp. 943-945
-
-
Benzinou, M.1
-
53
-
-
41749090524
-
-
Hinney, A. et al. Genome wide association (GWA) study for early onset extreme obesity supports the role of fat mass and obesity associated gene (FTO) variants. PLoS ONE 2, e1361 (2007). The first GWA study to specifically recruit obese subjects.
-
Hinney, A. et al. Genome wide association (GWA) study for early onset extreme obesity supports the role of fat mass and obesity associated gene (FTO) variants. PLoS ONE 2, e1361 (2007). The first GWA study to specifically recruit obese subjects.
-
-
-
-
54
-
-
0034905674
-
Mutational analysis of melanocortin-4 receptor, agouti-related protein, and alpha-melanocyte-stimulating hormone genes in severely obese children
-
Dubern, B. et al. Mutational analysis of melanocortin-4 receptor, agouti-related protein, and alpha-melanocyte-stimulating hormone genes in severely obese children. J. Pediatr. 139, 204-209 (2001).
-
(2001)
J. Pediatr
, vol.139
, pp. 204-209
-
-
Dubern, B.1
-
55
-
-
12144289073
-
Melanocortin-4 receptor gene variant I103 is negatively associated with obesity
-
Geller, F. et al. Melanocortin-4 receptor gene variant I103 is negatively associated with obesity. Am. J. Hum. Genet. 74, 572-581 (2004).
-
(2004)
Am. J. Hum. Genet
, vol.74
, pp. 572-581
-
-
Geller, F.1
-
56
-
-
28544447162
-
Association of the 103I MC104R allele with decreased body mass in 7937 participants of two population based surveys
-
Heid, I. M. et al. Association of the 103I MC104R allele with decreased body mass in 7937 participants of two population based surveys. J. Med. Genet. 42, e21 (2005).
-
(2005)
J. Med. Genet
, vol.42
-
-
Heid, I.M.1
-
57
-
-
34547839796
-
Non-synonymous polymorphisms in melanocortin-4 receptor protect against obesity: The two facets of a Janus obesity gene
-
Stutzmann, F. et al. Non-synonymous polymorphisms in melanocortin-4 receptor protect against obesity: the two facets of a Janus obesity gene. Hum. Mol. Genet. 16, 1837-1844 (2007).
-
(2007)
Hum. Mol. Genet
, vol.16
, pp. 1837-1844
-
-
Stutzmann, F.1
-
58
-
-
33644785980
-
ACDC/adiponectin polymorphisms are associated with severe childhood and adult obesity
-
Bouatia-Naji, N. et al. ACDC/adiponectin polymorphisms are associated with severe childhood and adult obesity. Diabetes 55, 545-550 (2006).
-
(2006)
Diabetes
, vol.55
, pp. 545-550
-
-
Bouatia-Naji, N.1
-
59
-
-
21644447527
-
Adiponectin gene variation associates with the increasing risk of type 2 diabetes in non-diabetic Japanese subjects
-
Nakatani, K. et al. Adiponectin gene variation associates with the increasing risk of type 2 diabetes in non-diabetic Japanese subjects. Int. J. Mol. Med. 15, 173-177 (2005).
-
(2005)
Int. J. Mol. Med
, vol.15
, pp. 173-177
-
-
Nakatani, K.1
-
60
-
-
26944500225
-
Genetic analysis of adiponectin and obesity in Hispanic families: The IRAS Family Study
-
Sutton, B. S. et al. Genetic analysis of adiponectin and obesity in Hispanic families: the IRAS Family Study. Hum. Genet. 117, 107-118 (2005).
-
(2005)
Hum. Genet
, vol.117
, pp. 107-118
-
-
Sutton, B.S.1
-
61
-
-
45049083452
-
A novel association of a polymorphism in the first intron of adiponectin gene with type 2 diabetes, obesity and hypoadiponectinemia in Asian Indians
-
Vimaleswaran, K. S. et al. A novel association of a polymorphism in the first intron of adiponectin gene with type 2 diabetes, obesity and hypoadiponectinemia in Asian Indians. Hum. Genet. 123, 599-605 (2008).
-
(2008)
Hum. Genet
, vol.123
, pp. 599-605
-
-
Vimaleswaran, K.S.1
-
62
-
-
45749158085
-
Endocannabinoid receptor 1 gene variations increase risk for obesity and modulate body mass index in European populations
-
Benzinou, M. et al. Endocannabinoid receptor 1 gene variations increase risk for obesity and modulate body mass index in European populations. Hum. Mol. Genet. 17, 1916-1921 (2008).
-
(2008)
Hum. Mol. Genet
, vol.17
, pp. 1916-1921
-
-
Benzinou, M.1
-
63
-
-
0033894555
-
Modulation of blood pressure and obesity with the dopamine D2 receptor gene TaqI polymorphism
-
Thomas, G. N., Tomlinson, B. & Critchley, J. A. Modulation of blood pressure and obesity with the dopamine D2 receptor gene TaqI polymorphism. Hypertension 36, 177-182 (2000).
-
(2000)
Hypertension
, vol.36
, pp. 177-182
-
-
Thomas, G.N.1
Tomlinson, B.2
Critchley, J.A.3
-
64
-
-
35748973918
-
Food reinforcement, the dopamine D2 receptor genotype, and energy intake in obese and nonobese humans
-
Epstein, L. H. et al. Food reinforcement, the dopamine D2 receptor genotype, and energy intake in obese and nonobese humans. Behav. Neurosci. 121, 877-886 (2007).
-
(2007)
Behav. Neurosci
, vol.121
, pp. 877-886
-
-
Epstein, L.H.1
-
65
-
-
27544454031
-
Complex HTR2C linkage disequilibrium and promoter associations with body mass index and serum leptin
-
McCarthy, S. et al. Complex HTR2C linkage disequilibrium and promoter associations with body mass index and serum leptin. Hum. Genet. 117, 545-557 (2005).
-
(2005)
Hum. Genet
, vol.117
, pp. 545-557
-
-
McCarthy, S.1
-
66
-
-
1842434558
-
2C receptor promoter polymorphism (HTR2C - 759C/T) is associated with obesity in women, and with resistance to weight loss in heterozygotes
-
2C receptor promoter polymorphism (HTR2C - 759C/T) is associated with obesity in women, and with resistance to weight loss in heterozygotes. Am. J. Med. Genet. B Neuropsychiatr. Genet. 126B, 124-127 (2004).
-
(2004)
Am. J. Med. Genet. B Neuropsychiatr. Genet
, vol.126 B
, pp. 124-127
-
-
Pooley, E.C.1
-
67
-
-
39449136247
-
Genes implicated in serotonergic and dopaminergic functioning predict BMI categories
-
Fuemmeler, B. F. et al. Genes implicated in serotonergic and dopaminergic functioning predict BMI categories. Obesity (Silver Spring) 16, 348-355 (2008).
-
(2008)
Obesity (Silver Spring)
, vol.16
, pp. 348-355
-
-
Fuemmeler, B.F.1
-
68
-
-
18344396039
-
A meta-analytic investigation of linkage and association of common leptin receptor (LEPR) polymorphisms with body mass index and waist circumference
-
Heo, M. et al. A meta-analytic investigation of linkage and association of common leptin receptor (LEPR) polymorphisms with body mass index and waist circumference. Int. J. Obes. Relat. Metab. Disord. 26, 640-646 (2002).
-
(2002)
Int. J. Obes. Relat. Metab. Disord
, vol.26
, pp. 640-646
-
-
Heo, M.1
-
69
-
-
79959503826
-
The International HapMap Project
-
The original description of the project to map the human variation that underpins much of the current human genetic studies. The International HapMap Consortium
-
The International HapMap Consortium. The International HapMap Project. Nature 426, 789-796 (2003). The original description of the project to map the human variation that underpins much of the current human genetic studies.
-
(2003)
Nature
, vol.426
, pp. 789-796
-
-
-
70
-
-
79959524146
-
A haplotype map of the human genome
-
The International HapMap Consortium
-
The International HapMap Consortium. A haplotype map of the human genome. Nature 437, 1299-1320 (2005).
-
(2005)
Nature
, vol.437
, pp. 1299-1320
-
-
-
71
-
-
35348983887
-
A second generation human haplotype map of over 3.1 million SNPs
-
The International HapMap Consortium
-
The International HapMap Consortium. A second generation human haplotype map of over 3.1 million SNPs. Nature 449, 851-861 (2007).
-
(2007)
Nature
, vol.449
, pp. 851-861
-
-
-
72
-
-
42349112088
-
Genome-wide association studies for complex traits: Consensus, uncertainty and challenges
-
McCarthy, M. I. et al. Genome-wide association studies for complex traits: consensus, uncertainty and challenges. Nature Rev. Genet. 9, 356-369 (2008).
-
(2008)
Nature Rev. Genet
, vol.9
, pp. 356-369
-
-
McCarthy, M.I.1
-
73
-
-
36549036104
-
The genetic basis of complex traits: Rare variants or "common gene, common disease"?
-
Iyengar, S. K. & Elston, R. C. The genetic basis of complex traits: rare variants or "common gene, common disease"? Methods Mol. Biol. 376, 71-84 (2007).
-
(2007)
Methods Mol. Biol
, vol.376
, pp. 71-84
-
-
Iyengar, S.K.1
Elston, R.C.2
-
74
-
-
58149163142
-
-
Willer, C. J. et al. Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nature Genet. 41, 25-34 (2009). A meta-analysis of 15 GWA studies for BMI associations reporting six novel loci.
-
Willer, C. J. et al. Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nature Genet. 41, 25-34 (2009). A meta-analysis of 15 GWA studies for BMI associations reporting six novel loci.
-
-
-
-
75
-
-
34249777814
-
Variation in FTO contributes to childhood obesity and severe adult obesity
-
Dina, C. et al. Variation in FTO contributes to childhood obesity and severe adult obesity. Nature Genet. 39, 724-726 (2007).
-
(2007)
Nature Genet
, vol.39
, pp. 724-726
-
-
Dina, C.1
-
76
-
-
84969213492
-
-
The Wellcome Trust Case Control Consortium. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 447, 661-678 (2007). A large-scale GWA study of seven common diseases, including type 2 diabetes.
-
The Wellcome Trust Case Control Consortium. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 447, 661-678 (2007). A large-scale GWA study of seven common diseases, including type 2 diabetes.
-
-
-
-
77
-
-
42249110521
-
FTO: The first gene contributing to common forms of human obesity
-
Loos, R. J. & Bouchard, C. FTO: the first gene contributing to common forms of human obesity. Obes. Rev. 9, 246-50 (2008).
-
(2008)
Obes. Rev
, vol.9
, pp. 246-250
-
-
Loos, R.J.1
Bouchard, C.2
-
78
-
-
36749041363
-
The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase
-
Gerken, T. et al. The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase. Science 318, 1469-1472 (2007).
-
(2007)
Science
, vol.318
, pp. 1469-1472
-
-
Gerken, T.1
-
79
-
-
48749132799
-
Polymorphisms of the FTO gene are associated with variation in energy intake, but not energy expenditure
-
2008
-
Speakman, J. R., Rance, K. A. & Johnstone, A. M. Polymorphisms of the FTO gene are associated with variation in energy intake, but not energy expenditure. Obesity (Silver Spring) 16, 1961-1965 (2008).
-
(1961)
Obesity (Silver Spring)
, vol.16
-
-
Speakman, J.R.1
Rance, K.A.2
Johnstone, A.M.3
-
80
-
-
68049093671
-
The FTO gene and measured food intake in children
-
Lond
-
Wardle, J., Llewellyn, C., Sanderson, S. & Plomin, R. The FTO gene and measured food intake in children. Int. J. Obes. (Lond.) (2008).
-
(2008)
Int. J. Obes
-
-
Wardle, J.1
Llewellyn, C.2
Sanderson, S.3
Plomin, R.4
-
81
-
-
51649128621
-
Obesity associated genetic variation in FTO is associated with diminished satiety
-
Wardle, J. et al. Obesity associated genetic variation in FTO is associated with diminished satiety. J. Clin. Endocrinol. Metab. 93, 3640-3643 (2008).
-
(2008)
J. Clin. Endocrinol. Metab
, vol.93
, pp. 3640-3643
-
-
Wardle, J.1
-
82
-
-
42949102733
-
The common rs9939609 gene variant of the fat mass- and obesity-associated gene FTO is related to fat cell lipolysis
-
Wahlen, K., Sjolin, E. & Hoffstedt, J. The common rs9939609 gene variant of the fat mass- and obesity-associated gene FTO is related to fat cell lipolysis. J. Lipid Res. 49, 607-611 (2008).
-
(2008)
J. Lipid Res
, vol.49
, pp. 607-611
-
-
Wahlen, K.1
Sjolin, E.2
Hoffstedt, J.3
-
83
-
-
38449098674
-
Low physical activity accentuates the effect of the FTO rs9939609 polymorphism on body fat accumulation
-
Andreasen, C. H. et al. Low physical activity accentuates the effect of the FTO rs9939609 polymorphism on body fat accumulation. Diabetes 57, 95-101 (2008).
-
(2008)
Diabetes
, vol.57
, pp. 95-101
-
-
Andreasen, C.H.1
-
84
-
-
44349142294
-
Common variants near MC4R are associated with fat mass, weight and risk of obesity
-
Loos, R. J. et al. Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nature Genet. 40, 768-775 (2008).
-
(2008)
Nature Genet
, vol.40
, pp. 768-775
-
-
Loos, R.J.1
-
85
-
-
44349166252
-
Common genetic variation near MC4R is associated with waist circumference and insulin resistance
-
Chambers, J. C. et al. Common genetic variation near MC4R is associated with waist circumference and insulin resistance. Nature Genet. 40, 716-188 (2008).
-
(2008)
Nature Genet
, vol.40
, pp. 716-188
-
-
Chambers, J.C.1
-
86
-
-
51449116347
-
Non-replication of genomewide based associations between common variants in INSIG2 and PFKP and obesity in studies of 18,014 Danes
-
Andreasen, C. H. et al. Non-replication of genomewide based associations between common variants in INSIG2 and PFKP and obesity in studies of 18,014 Danes. PLoS ONE 3, e2872 (2008).
-
(2008)
PLoS ONE
, vol.3
-
-
Andreasen, C.H.1
-
87
-
-
54949113309
-
The common obesity variant near MC4R gene is associated with higher intakes of total energy and dietary fat, weight change and diabetes risk in women
-
Qi, L., Kraft, P., Hunter, D. J. & Hu, F. B. The common obesity variant near MC4R gene is associated with higher intakes of total energy and dietary fat, weight change and diabetes risk in women. Hum. Mol. Genet. 17, 3502-8 (2008).
-
(2008)
Hum. Mol. Genet
, vol.17
, pp. 3502-3508
-
-
Qi, L.1
Kraft, P.2
Hunter, D.J.3
Hu, F.B.4
-
88
-
-
33645825830
-
A common genetic variant is associated with adult and childhood obesity
-
Herbert, A. et al. A common genetic variant is associated with adult and childhood obesity. Science 312, 279-283 (2006).
-
(2006)
Science
, vol.312
, pp. 279-283
-
-
Herbert, A.1
-
89
-
-
33846933276
-
-
Dina, C. et al. Comment on A common genetic variant is associated with adult and childhood obesity. Science 315, 187b; author reply 187e (2007).
-
Dina, C. et al. Comment on "A common genetic variant is associated with adult and childhood obesity". Science 315, 187b; author reply 187e (2007).
-
-
-
-
90
-
-
33846933276
-
-
Rosskopf, D. et al. Comment on A common genetic variant is associated with adult and childhood obesity. Science 315, 187; author reply 187e (2007).
-
Rosskopf, D. et al. Comment on "A common genetic variant is associated with adult and childhood obesity". Science 315, 187; author reply 187e (2007).
-
-
-
-
91
-
-
33846936809
-
Comment on A common genetic variant is associated with adult and childhood obesity
-
187c; author reply 187e
-
Loos, R. J., Barroso, I., O'Rahilly, S. & Wareham, N. J. Comment on "A common genetic variant is associated with adult and childhood obesity". Science 315, 187c; author reply 187e (2007).
-
(2007)
Science
, vol.315
-
-
Loos, R.J.1
Barroso, I.2
O'Rahilly, S.3
Wareham, N.J.4
-
92
-
-
34247576412
-
The association of a SNP upstream of INSIG2 with body mass index is reproduced in several but not all cohorts
-
Lyon, H. N. et al. The association of a SNP upstream of INSIG2 with body mass index is reproduced in several but not all cohorts. PLoS Genet. 3, e61 (2007).
-
(2007)
PLoS Genet
, vol.3
-
-
Lyon, H.N.1
-
93
-
-
34547625955
-
Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits
-
Scuteri, A. et al. Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits. PLoS Genet. 3, e115 (2007).
-
(2007)
PLoS Genet
, vol.3
-
-
Scuteri, A.1
-
94
-
-
59149097625
-
-
Meyre, D. et al. Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations. Nature Genet. 41, 157-159 (2009). The first GWA study for severe adult and child obesity reporting three novel loci.
-
Meyre, D. et al. Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations. Nature Genet. 41, 157-159 (2009). The first GWA study for severe adult and child obesity reporting three novel loci.
-
-
-
-
95
-
-
0037007048
-
Large-scale analysis of the human and mouse transcriptomes
-
Su, A. I. et al. Large-scale analysis of the human and mouse transcriptomes. Proc. Natl Acad. Sci. USA 99, 4465-4470 (2002).
-
(2002)
Proc. Natl Acad. Sci. USA
, vol.99
, pp. 4465-4470
-
-
Su, A.I.1
-
96
-
-
0036789434
-
Relevance of Niemann-Pick type C1 protein expression in controlling plasma cholesterol and biliary lipid secretion in mice
-
Amigo, L. et al. Relevance of Niemann-Pick type C1 protein expression in controlling plasma cholesterol and biliary lipid secretion in mice. Hepatology 36, 819-828 (2002).
-
(2002)
Hepatology
, vol.36
, pp. 819-828
-
-
Amigo, L.1
-
97
-
-
38549141572
-
Cellular cholesterol trafficking and compartmentalization
-
Ikonen, E. Cellular cholesterol trafficking and compartmentalization. Nature Rev. Mol. Cell Biol. 9, 125-138 (2008).
-
(2008)
Nature Rev. Mol. Cell Biol
, vol.9
, pp. 125-138
-
-
Ikonen, E.1
-
98
-
-
33749234799
-
Lipid imbalance in the neurological disorder, Niemann-Pick C disease
-
Vance, J. E. Lipid imbalance in the neurological disorder, Niemann-Pick C disease. FEBS Lett. 580, 5518-5524 (2006).
-
(2006)
FEBS Lett
, vol.580
, pp. 5518-5524
-
-
Vance, J.E.1
-
99
-
-
0033049909
-
Cholesterol balance and metabolism in mice with loss of function of Niemann-Pick C protein
-
Xie, C., Turley, S. D., Pentchev, P. G. & Dietschy, J. M. Cholesterol balance and metabolism in mice with loss of function of Niemann-Pick C protein. Am. J. Physiol. 276, E336-E344 (1999).
-
(1999)
Am. J. Physiol
, vol.276
-
-
Xie, C.1
Turley, S.D.2
Pentchev, P.G.3
Dietschy, J.M.4
-
100
-
-
44849086097
-
Genome-wide association scans identified CTNNBL1 as a novel gene for obesity
-
Liu, Y. J. et al. Genome-wide association scans identified CTNNBL1 as a novel gene for obesity. Hum. Mol. Genet. 17, 1803-1813 (2008).
-
(2008)
Hum. Mol. Genet
, vol.17
, pp. 1803-1813
-
-
Liu, Y.J.1
-
101
-
-
44849083863
-
TCF7L2 genetic defect and type 2 diabetes
-
Cauchi, S. & Froguel, P. TCF7L2 genetic defect and type 2 diabetes. Curr. Diab. Rep. 8, 149-155 (2008).
-
(2008)
Curr. Diab. Rep
, vol.8
, pp. 149-155
-
-
Cauchi, S.1
Froguel, P.2
-
102
-
-
0034637103
-
Inhibition of adipogenesis by Wnt signaling
-
Ross, S. E. et al. Inhibition of adipogenesis by Wnt signaling. Science 289, 950-953 (2000).
-
(2000)
Science
, vol.289
, pp. 950-953
-
-
Ross, S.E.1
-
103
-
-
33845896536
-
Wnt-β-catenin signaling initiates taste papilla development
-
Liu, F. et al. Wnt-β-catenin signaling initiates taste papilla development. Nature Genet. 39, 106-112 (2007).
-
(2007)
Nature Genet
, vol.39
, pp. 106-112
-
-
Liu, F.1
-
104
-
-
58149163141
-
Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity
-
Thorleifsson, G. et al. Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity. Nature Genet. 41, 18-24 (2009).
-
(2009)
Nature Genet
, vol.41
, pp. 18-24
-
-
Thorleifsson, G.1
-
105
-
-
50449091503
-
The power of the extreme in elucidating obesity
-
Froguel, P. & Blakemore, A. I. The power of the extreme in elucidating obesity. N. Engl. J. Med. 359, 891-893 (2008).
-
(2008)
N. Engl. J. Med
, vol.359
, pp. 891-893
-
-
Froguel, P.1
Blakemore, A.I.2
-
106
-
-
41549126540
-
On the replication of genetic associations: Timing can be everything!
-
Lasky-Su, J. et al. On the replication of genetic associations: timing can be everything! Am. J. Hum. Genet. 82, 849-858 (2008).
-
(2008)
Am. J. Hum. Genet
, vol.82
, pp. 849-858
-
-
Lasky-Su, J.1
-
107
-
-
60349092402
-
Mapping complex disease traits with global gene expression
-
Cookson, W., Liang, L., Abecasis, G., Moffatt, M. & Lathrop, M. Mapping complex disease traits with global gene expression. Nature Rev. Genet. 10, 184-194 (2009).
-
(2009)
Nature Rev. Genet
, vol.10
, pp. 184-194
-
-
Cookson, W.1
Liang, L.2
Abecasis, G.3
Moffatt, M.4
Lathrop, M.5
-
108
-
-
58149382045
-
Transcriptomic and metabonomic profiling of obesity-prone and obesity-resistant rats under high fat diet
-
Li, H. et al. Transcriptomic and metabonomic profiling of obesity-prone and obesity-resistant rats under high fat diet. J. Proteome Res. 7, 4775-4783 (2008).
-
(2008)
J. Proteome Res
, vol.7
, pp. 4775-4783
-
-
Li, H.1
-
109
-
-
52749091008
-
Increase in endoplasmic reticulum stress-related proteins and genes in adipose tissue of obese, insulin-resistant individuals
-
Boden, G. et al. Increase in endoplasmic reticulum stress-related proteins and genes in adipose tissue of obese, insulin-resistant individuals. Diabetes 57, 2438-2444 (2008).
-
(2008)
Diabetes
, vol.57
, pp. 2438-2444
-
-
Boden, G.1
-
110
-
-
38449117820
-
Designing candidate gene and genome-wide case-control association studies
-
Zondervan, K. T. & Cardon, L. R. Designing candidate gene and genome-wide case-control association studies. Nature Protoc. 2, 2492-2501 (2007).
-
(2007)
Nature Protoc
, vol.2
, pp. 2492-2501
-
-
Zondervan, K.T.1
Cardon, L.R.2
-
111
-
-
40749102101
-
An overview of the genetic dissection of complex traits
-
Rao, D. C. An overview of the genetic dissection of complex traits. Adv. Genet. 60, 3-34 (2008).
-
(2008)
Adv. Genet
, vol.60
, pp. 3-34
-
-
Rao, D.C.1
-
112
-
-
41649087155
-
Common statistical issues in genome-wide association studies: A review on power, data quality control, genotype calling and population structure
-
Teo, Y. Y. Common statistical issues in genome-wide association studies: a review on power, data quality control, genotype calling and population structure. Curr. Opin. Lipidol. 19, 133-143 (2008).
-
(2008)
Curr. Opin. Lipidol
, vol.19
, pp. 133-143
-
-
Teo, Y.Y.1
-
113
-
-
40149111451
-
What can genome-wide association studies tell us about the genetics of common disease?
-
Iles, M. M. What can genome-wide association studies tell us about the genetics of common disease? PLoS Genet. 4, e33 (2008).
-
(2008)
PLoS Genet
, vol.4
-
-
Iles, M.M.1
-
114
-
-
41649087366
-
Family study designs in the age of genome-wide association studies: Experience from the Framingham Heart Study
-
Cupples, L. A. Family study designs in the age of genome-wide association studies: experience from the Framingham Heart Study. Curr. Opin. Lipidol. 19, 144-150 (2008).
-
(2008)
Curr. Opin. Lipidol
, vol.19
, pp. 144-150
-
-
Cupples, L.A.1
-
115
-
-
33748797136
-
Genes, environment and the value of prospective cohort studies
-
Manolio, T. A., Bailey-Wilson, J. E. & Collins, F. S. Genes, environment and the value of prospective cohort studies. Nature Rev. Genet. 7, 812-820 (2006).
-
(2006)
Nature Rev. Genet
, vol.7
, pp. 812-820
-
-
Manolio, T.A.1
Bailey-Wilson, J.E.2
Collins, F.S.3
-
116
-
-
59949103364
-
-
Lowe, J. K. et al. Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae. PLoS Genet. 5, e1000365 (2009).
-
Lowe, J. K. et al. Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae. PLoS Genet. 5, e1000365 (2009).
-
-
-
-
117
-
-
68049090525
-
A rare variant in the visfatin gene (NAMPT/PBEF1) is associated with protection from obesity. Obesity (Silver Spring)
-
in the press
-
Blakemore, A. I. et al. A rare variant in the visfatin gene (NAMPT/PBEF1) is associated with protection from obesity. Obesity (Silver Spring) (in the press).
-
-
-
Blakemore, A.I.1
-
118
-
-
34047098731
-
A Mal functional variant is associated with protection against invasive pneumococcal disease, bacteremia, malaria and tuberculosis
-
Khor, C. C. et al. A Mal functional variant is associated with protection against invasive pneumococcal disease, bacteremia, malaria and tuberculosis. Nature Genet. 39, 523-528 (2007).
-
(2007)
Nature Genet
, vol.39
, pp. 523-528
-
-
Khor, C.C.1
-
119
-
-
65249131713
-
Rare variants of IFIH1, a gene implicated in antiviral responses, protect against type 1 diabetes
-
Nejentsev, S., Walker, N., Riches, D., Egholm, M. & Todd, J. A. Rare variants of IFIH1, a gene implicated in antiviral responses, protect against type 1 diabetes. Science 324, 387-389 (2009).
-
(2009)
Science
, vol.324
, pp. 387-389
-
-
Nejentsev, S.1
Walker, N.2
Riches, D.3
Egholm, M.4
Todd, J.A.5
-
120
-
-
64849092309
-
Exomic sequencing identifies PALB2 as a pancreatic cancer susceptibility gene
-
Jones, S. et al. Exomic sequencing identifies PALB2 as a pancreatic cancer susceptibility gene. Science 324, 217 (2009).
-
(2009)
Science
, vol.324
, pp. 217
-
-
Jones, S.1
-
121
-
-
33846978695
-
Relative impact of nucleotide and copy number variation on gene expression phenotypes
-
The first paper to describe the effects of copy number variation on gene expression
-
Stranger, B. E. et al. Relative impact of nucleotide and copy number variation on gene expression phenotypes. Science 315, 848-853 (2007). The first paper to describe the effects of copy number variation on gene expression.
-
(2007)
Science
, vol.315
, pp. 848-853
-
-
Stranger, B.E.1
-
122
-
-
35748971743
-
Array CGH analysis of copy number variation identifies 1,284 new genes variant in healthy white males: Implications for association studies of complex diseases
-
de Smith, A. J. et al. Array CGH analysis of copy number variation identifies 1,284 new genes variant in healthy white males: implications for association studies of complex diseases. Hum. Mol. Genet. 16, 2783-2794 (2007).
-
(2007)
Hum. Mol. Genet
, vol.16
, pp. 2783-2794
-
-
de Smith, A.J.1
-
123
-
-
31144469134
-
Structural variation in the human genome
-
Feuk, L., Carson, A. R. & Scherer, S. W. Structural variation in the human genome. Nature Rev. Genet. 7, 85-97 (2006).
-
(2006)
Nature Rev. Genet
, vol.7
, pp. 85-97
-
-
Feuk, L.1
Carson, A.R.2
Scherer, S.W.3
-
124
-
-
33748272115
-
High-resolution genomic profiling of chromosomal aberrations using Infinium whole-genome genotyping
-
Peiffer, D. A. et al. High-resolution genomic profiling of chromosomal aberrations using Infinium whole-genome genotyping. Genome Res. 16, 1136-1148 (2006).
-
(2006)
Genome Res
, vol.16
, pp. 1136-1148
-
-
Peiffer, D.A.1
-
125
-
-
52949141845
-
Integrated detection and population-genetic analysis of SNPs and copy number variation
-
McCarroll, S. A. et al. Integrated detection and population-genetic analysis of SNPs and copy number variation. Nature Genet. 40, 1166-1174 (2008).
-
(2008)
Nature Genet
, vol.40
, pp. 1166-1174
-
-
McCarroll, S.A.1
-
126
-
-
37349084293
-
Assessment of algorithms for high throughput detection of genomic copy number variation in oligonucleotide microarray data
-
Baross, A. et al. Assessment of algorithms for high throughput detection of genomic copy number variation in oligonucleotide microarray data. BMC Bioinformatics 8, 368 (2007).
-
(2007)
BMC Bioinformatics
, vol.8
, pp. 368
-
-
Baross, A.1
-
127
-
-
49449111926
-
Mechanisms of imprinting of the Prader-Willi/Angelman region
-
Horsthemke, B. & Wagstaff, J. Mechanisms of imprinting of the Prader-Willi/Angelman region. Am. J. Med. Genet. A 146A, 2041-2052 (2008).
-
(2008)
Am. J. Med. Genet. A
, vol.146 A
, pp. 2041-2052
-
-
Horsthemke, B.1
Wagstaff, J.2
-
128
-
-
13844253255
-
Possible genomic imprinting of three human obesity-related genetic loci
-
Dong, C. et al. Possible genomic imprinting of three human obesity-related genetic loci. Am. J. Hum. Genet. 76, 427-437 (2005).
-
(2005)
Am. J. Hum. Genet
, vol.76
, pp. 427-437
-
-
Dong, C.1
-
129
-
-
33749567351
-
Assessment of genetic linkage and parent-of-origin effects on obesity
-
Guo, Y. F. et al. Assessment of genetic linkage and parent-of-origin effects on obesity. J. Clin. Endocrinol. Metab. 91, 4001-4005 (2006).
-
(2006)
J. Clin. Endocrinol. Metab
, vol.91
, pp. 4001-4005
-
-
Guo, Y.F.1
-
130
-
-
38849090146
-
The thrifty epigenotype: An acquired and heritable predisposition for obesity and diabetes?
-
Stoger, R. The thrifty epigenotype: an acquired and heritable predisposition for obesity and diabetes? Bioessays 30, 156-166 (2008).
-
(2008)
Bioessays
, vol.30
, pp. 156-166
-
-
Stoger, R.1
-
131
-
-
33644649616
-
High-throughput DNA methylation profiling using universal bead arrays
-
Bibikova, M. et al. High-throughput DNA methylation profiling using universal bead arrays. Genome Res. 16, 383-393 (2006).
-
(2006)
Genome Res
, vol.16
, pp. 383-393
-
-
Bibikova, M.1
-
132
-
-
23044514626
-
Chromosome-wide and promoter-specific analyses identify sites of differential DNA methylation in normal and transformed human cells
-
Weber, M. et al. Chromosome-wide and promoter-specific analyses identify sites of differential DNA methylation in normal and transformed human cells. Nature Genet. 37, 853-862 (2005).
-
(2005)
Nature Genet
, vol.37
, pp. 853-862
-
-
Weber, M.1
-
133
-
-
36448972673
-
Evaluation and integration of 49 genome-wide experiments and the prediction of previously unknown obesity-related genes
-
The first attempt at a systems biology approach to integrating obesity research results identifies novel genes
-
English, S. B. & Butte, A. J. Evaluation and integration of 49 genome-wide experiments and the prediction of previously unknown obesity-related genes. Bioinformatics 23, 2910-2917 (2007). The first attempt at a systems biology approach to integrating obesity research results identifies novel genes.
-
(2007)
Bioinformatics
, vol.23
, pp. 2910-2917
-
-
English, S.B.1
Butte, A.J.2
-
134
-
-
34250682264
-
A comparison of direct vs. self-report measures for assessing height, weight and body mass index: A systematic review
-
Gorber, S. C., Tremblay, M., Moher, D. & Gorber, B. A comparison of direct vs. self-report measures for assessing height, weight and body mass index: a systematic review. Obes. Rev. 8, 307-326 (2007).
-
(2007)
Obes. Rev
, vol.8
, pp. 307-326
-
-
Gorber, S.C.1
Tremblay, M.2
Moher, D.3
Gorber, B.4
-
135
-
-
39449136273
-
Whole-body three-dimensional photonic scanning: A new technique for obesity research and clinical practice
-
Wells, J. C., Ruto, A. & Treleaven, P. Whole-body three-dimensional photonic scanning: a new technique for obesity research and clinical practice. Int. J. Obes. (Lond.) 32, 232-238 (2008).
-
(2008)
Int. J. Obes. (Lond.)
, vol.32
, pp. 232-238
-
-
Wells, J.C.1
Ruto, A.2
Treleaven, P.3
-
136
-
-
33846067748
-
Body-composition assessment in infancy: Air-displacement plethysmography compared with a reference 4-compartment model
-
Ellis, K. J. et al. Body-composition assessment in infancy: air-displacement plethysmography compared with a reference 4-compartment model. Am. J. Clin. Nutr. 85, 90-95 (2007).
-
(2007)
Am. J. Clin. Nutr
, vol.85
, pp. 90-95
-
-
Ellis, K.J.1
-
137
-
-
84934442888
-
Application of imaging and other noninvasive techniques in determining adipose tissue mass
-
Shen, W. & Chen, J. Application of imaging and other noninvasive techniques in determining adipose tissue mass. Methods Mol. Biol. 456, 39-54 (2008).
-
(2008)
Methods Mol. Biol
, vol.456
, pp. 39-54
-
-
Shen, W.1
Chen, J.2
-
138
-
-
36448967107
-
Sonographic assessment of regional adiposity
-
Vlachos, I. S., Hatziioannou, A., Perelas, A. & Perrea, D. N. Sonographic assessment of regional adiposity. AJR Am. J. Roentgenol. 189, 1545-1553 (2007).
-
(2007)
AJR Am. J. Roentgenol
, vol.189
, pp. 1545-1553
-
-
Vlachos, I.S.1
Hatziioannou, A.2
Perelas, A.3
Perrea, D.N.4
-
139
-
-
0036727395
-
Validity of the assessment of dietary intake: Problems of misreporting
-
Westerterp, K. R. & Goris, A. H. Validity of the assessment of dietary intake: problems of misreporting. Curr. Opin. Clin. Nutr. Metab. Care 5, 489-493 (2002).
-
(2002)
Curr. Opin. Clin. Nutr. Metab. Care
, vol.5
, pp. 489-493
-
-
Westerterp, K.R.1
Goris, A.H.2
-
140
-
-
52149087010
-
Digital photography as a tool to measure school cafeteria consumption
-
Swanson, M. Digital photography as a tool to measure school cafeteria consumption. J. Sch. Health 78, 432-437 (2008).
-
(2008)
J. Sch. Health
, vol.78
, pp. 432-437
-
-
Swanson, M.1
-
141
-
-
49849083849
-
Performance of a method for identifying the unique dietary patterns of adult women and men: The Framingham nutrition studies
-
Pencina, M. J., Millen, B. E., Hayes, L. J. & D'Agostino, R. B. Performance of a method for identifying the unique dietary patterns of adult women and men: the Framingham nutrition studies. J. Am. Diet Assoc. 108, 1453-1460 (2008).
-
(2008)
J. Am. Diet Assoc
, vol.108
, pp. 1453-1460
-
-
Pencina, M.J.1
Millen, B.E.2
Hayes, L.J.3
D'Agostino, R.B.4
-
142
-
-
49849101641
-
Breakfast skipping and body mass index among adolescents in Greece: Whether an association exists depends on how breakfast skipping is defined
-
Dialektakou, K. D. & Vranas, P. B. Breakfast skipping and body mass index among adolescents in Greece: whether an association exists depends on how breakfast skipping is defined. J. Am. Diet Assoc. 108, 1517-1525 (2008).
-
(2008)
J. Am. Diet Assoc
, vol.108
, pp. 1517-1525
-
-
Dialektakou, K.D.1
Vranas, P.B.2
-
143
-
-
33748931457
-
Central nervous system control of food intake and body weight
-
Morton, G. J., Cummings, D. E., Baskin, D. G., Barsh, G. S. & Schwartz, M. W. Central nervous system control of food intake and body weight. Nature 443, 289-295 (2006).
-
(2006)
Nature
, vol.443
, pp. 289-295
-
-
Morton, G.J.1
Cummings, D.E.2
Baskin, D.G.3
Barsh, G.S.4
Schwartz, M.W.5
-
144
-
-
45549086298
-
Adipose tissue hormones and the regulation of food intake
-
Henry, B. A. & Clarke, I. J. Adipose tissue hormones and the regulation of food intake. J. Neuroendocrinol. 20, 842-849 (2008).
-
(2008)
J. Neuroendocrinol
, vol.20
, pp. 842-849
-
-
Henry, B.A.1
Clarke, I.J.2
-
145
-
-
33845864967
-
Adipocytes as regulators of energy balance and glucose homeostasis
-
Rosen, E. D. & Spiegelman, B. M. Adipocytes as regulators of energy balance and glucose homeostasis. Nature 444, 847-853 (2006).
-
(2006)
Nature
, vol.444
, pp. 847-853
-
-
Rosen, E.D.1
Spiegelman, B.M.2
-
146
-
-
0035936764
-
Obesity and the regulation of energy balance
-
Spiegelman, B. M. & Flier, J. S. Obesity and the regulation of energy balance. Cell 104, 531-543 (2001).
-
(2001)
Cell
, vol.104
, pp. 531-543
-
-
Spiegelman, B.M.1
Flier, J.S.2
-
147
-
-
33847419918
-
Common variation in LMNA increases susceptibility to type 2 diabetes and associates with elevated fasting glycemia and estimates of body fat and height in the general population: Studies of 7,495 Danish whites
-
Wegner, L. et al. Common variation in LMNA increases susceptibility to type 2 diabetes and associates with elevated fasting glycemia and estimates of body fat and height in the general population: studies of 7,495 Danish whites. Diabetes 56, 694-698 (2007).
-
(2007)
Diabetes
, vol.56
, pp. 694-698
-
-
Wegner, L.1
-
148
-
-
19944427023
-
Genetic linkage and association of the growth hormone secretagogue receptor (ghrelin receptor) gene in human obesity
-
Baessler, A. et al. Genetic linkage and association of the growth hormone secretagogue receptor (ghrelin receptor) gene in human obesity. Diabetes 54, 259-267 (2005).
-
(2005)
Diabetes
, vol.54
, pp. 259-267
-
-
Baessler, A.1
-
149
-
-
59349092716
-
Functional SOCS1 polymorphisms are associated with variation in obesity in whites
-
Gylvin, T. et al. Functional SOCS1 polymorphisms are associated with variation in obesity in whites. Diabetes Obes. Metab. 11, 196-203 (2009).
-
(2009)
Diabetes Obes. Metab
, vol.11
, pp. 196-203
-
-
Gylvin, T.1
-
150
-
-
60549087134
-
Polymorphisms near SOCS3 are associated with obesity and glucose homeostasis traits in Hispanic Americans from the Insulin Resistance Atherosclerosis Family Study
-
Talbert, M. E. et al. Polymorphisms near SOCS3 are associated with obesity and glucose homeostasis traits in Hispanic Americans from the Insulin Resistance Atherosclerosis Family Study. Hum. Genet. 125, 153-162 (2009).
-
(2009)
Hum. Genet
, vol.125
, pp. 153-162
-
-
Talbert, M.E.1
-
151
-
-
64549160686
-
Variation in the gene encoding Kruppel-like factor 7 influences body fat: Studies of 14,818 Danes
-
Zobel, D. et al. Variation in the gene encoding Kruppel-like factor 7 influences body fat: studies of 14,818 Danes. Eur. J. Endocrinol. 160, 603-609 (2009).
-
(2009)
Eur. J. Endocrinol
, vol.160
, pp. 603-609
-
-
Zobel, D.1
-
152
-
-
36248986199
-
Association of single-nucleotide polymorphisms in MTMR9 gene with obesity
-
Yanagiya, T. et al. Association of single-nucleotide polymorphisms in MTMR9 gene with obesity. Hum. Mol. Genet. 16, 3017-3026 (2007).
-
(2007)
Hum. Mol. Genet
, vol.16
, pp. 3017-3026
-
-
Yanagiya, T.1
-
153
-
-
50149083052
-
Preferential reciprocal transfer of paternal/maternal DLK1 alleles to obese children: First evidence of polar overdominance in humans
-
Wermter, A. K. et al. Preferential reciprocal transfer of paternal/maternal DLK1 alleles to obese children: first evidence of polar overdominance in humans. Eur. J. Hum. Genet. 16, 1126-1134 (2008).
-
(2008)
Eur. J. Hum. Genet
, vol.16
, pp. 1126-1134
-
-
Wermter, A.K.1
-
154
-
-
33748745768
-
TBC1D1 is a candidate for a severe obesity gene and evidence for a gene/gene interaction in obesity predisposition
-
Stone, S. et al. TBC1D1 is a candidate for a severe obesity gene and evidence for a gene/gene interaction in obesity predisposition. Hum. Mol. Genet. 15, 2709-20 (2006).
-
(2006)
Hum. Mol. Genet
, vol.15
, pp. 2709-2720
-
-
Stone, S.1
-
155
-
-
33846784878
-
Single nucleotide polymorphisms in the neuropeptide Y2 receptor (NPY2R) gene and association with severe obesity in French white subjects
-
Siddiq, A. et al. Single nucleotide polymorphisms in the neuropeptide Y2 receptor (NPY2R) gene and association with severe obesity in French white subjects. Diabetologia 50, 574-84 (2007).
-
(2007)
Diabetologia
, vol.50
, pp. 574-584
-
-
Siddiq, A.1
|