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Volumn 38, Issue 4, 2013, Pages 644-654

The immune system as a sensor of the metabolic state

Author keywords

[No Author keywords available]

Indexed keywords

B LYMPHOCYTE; BROWN ADIPOSE TISSUE; HYPOTHALAMUS; IMMUNE SYSTEM; IMMUNITY; LIVER; MACROPHAGE; MAST CELL; METABOLIC DISORDER; METABOLIC REGULATION; METABOLISM; NEUTROPHIL; NONHUMAN; OVERNUTRITION; PRIORITY JOURNAL; REVIEW; T LYMPHOCYTE; WHITE ADIPOSE TISSUE;

EID: 84876771596     PISSN: 10747613     EISSN: 10974180     Source Type: Journal    
DOI: 10.1016/j.immuni.2013.04.001     Document Type: Review
Times cited : (179)

References (79)
  • 2
    • 84655169635 scopus 로고    scopus 로고
    • A systems biology approach to nutritional immunology - focus on innate immunity
    • Afacan N.J., Fjell C.D., Hancock R.E. A systems biology approach to nutritional immunology - focus on innate immunity. Mol. Aspects Med. 2012, 33:14-25.
    • (2012) Mol. Aspects Med. , vol.33 , pp. 14-25
    • Afacan, N.J.1    Fjell, C.D.2    Hancock, R.E.3
  • 3
    • 0037059330 scopus 로고    scopus 로고
    • Phosphorylation of Ser307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin action
    • Aguirre V., Werner E.D., Giraud J., Lee Y.H., Shoelson S.E., White M.F. Phosphorylation of Ser307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin action. J. Biol. Chem. 2002, 277:1531-1537.
    • (2002) J. Biol. Chem. , vol.277 , pp. 1531-1537
    • Aguirre, V.1    Werner, E.D.2    Giraud, J.3    Lee, Y.H.4    Shoelson, S.E.5    White, M.F.6
  • 6
    • 84866159245 scopus 로고    scopus 로고
    • Evolution of vertebrate immunity
    • Boehm T. Evolution of vertebrate immunity. Curr. Biol. 2012, 22:R722-R732.
    • (2012) Curr. Biol. , vol.22
    • Boehm, T.1
  • 7
    • 84867911343 scopus 로고    scopus 로고
    • Biomarkers and immune-modulating therapies for type 2 diabetes
    • Brooks-Worrell B., Narla R., Palmer J.P. Biomarkers and immune-modulating therapies for type 2 diabetes. Trends Immunol. 2012, 33:546-553.
    • (2012) Trends Immunol. , vol.33 , pp. 546-553
    • Brooks-Worrell, B.1    Narla, R.2    Palmer, J.P.3
  • 8
    • 84860277644 scopus 로고    scopus 로고
    • Hypothalamic inflammation: a double-edged sword to nutritional diseases
    • Cai D., Liu T. Hypothalamic inflammation: a double-edged sword to nutritional diseases. Ann. N Y Acad. Sci. 2011, 1243:E1-E39.
    • (2011) Ann. N Y Acad. Sci. , vol.1243
    • Cai, D.1    Liu, T.2
  • 9
    • 14644427890 scopus 로고    scopus 로고
    • Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB
    • Cai D., Yuan M., Frantz D.F., Melendez P.A., Hansen L., Lee J., Shoelson S.E. Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB. Nat. Med. 2005, 11:183-190.
    • (2005) Nat. Med. , vol.11 , pp. 183-190
    • Cai, D.1    Yuan, M.2    Frantz, D.F.3    Melendez, P.A.4    Hansen, L.5    Lee, J.6    Shoelson, S.E.7
  • 10
    • 78651313711 scopus 로고    scopus 로고
    • Nonshivering thermogenesis and its adequate measurement in metabolic studies
    • Cannon B., Nedergaard J. Nonshivering thermogenesis and its adequate measurement in metabolic studies. J. Exp. Biol. 2011, 214:242-253.
    • (2011) J. Exp. Biol. , vol.214 , pp. 242-253
    • Cannon, B.1    Nedergaard, J.2
  • 13
    • 79956303498 scopus 로고    scopus 로고
    • Regulation of the antimicrobial response by NLR proteins
    • Elinav E., Strowig T., Henao-Mejia J., Flavell R.A. Regulation of the antimicrobial response by NLR proteins. Immunity 2011, 34:665-679.
    • (2011) Immunity , vol.34 , pp. 665-679
    • Elinav, E.1    Strowig, T.2    Henao-Mejia, J.3    Flavell, R.A.4
  • 15
    • 79951558318 scopus 로고    scopus 로고
    • National, regional, and global trends in body-mass index since 1980: systematic analysis of health examination surveys and epidemiological studies with 960 country-years and 9·1 million participants
    • Global Burden of Metabolic Risk Factors of Chronic Diseases Collaborating Group (Body Mass Index)
    • Finucane M.M., Stevens G.A., Cowan M.J., Danaei G., Lin J.K., Paciorek C.J., Singh G.M., Gutierrez H.R., Lu Y., Bahalim A.N., et al. National, regional, and global trends in body-mass index since 1980: systematic analysis of health examination surveys and epidemiological studies with 960 country-years and 9·1 million participants. Lancet 2011, 377:557-567. Global Burden of Metabolic Risk Factors of Chronic Diseases Collaborating Group (Body Mass Index).
    • (2011) Lancet , vol.377 , pp. 557-567
    • Finucane, M.M.1    Stevens, G.A.2    Cowan, M.J.3    Danaei, G.4    Lin, J.K.5    Paciorek, C.J.6    Singh, G.M.7    Gutierrez, H.R.8    Lu, Y.9    Bahalim, A.N.10
  • 17
    • 77950190436 scopus 로고    scopus 로고
    • Distribution and development of brown adipocytes in the murine and human adipose organ
    • Frontini A., Cinti S. Distribution and development of brown adipocytes in the murine and human adipose organ. Cell Metab. 2010, 11:253-256.
    • (2010) Cell Metab. , vol.11 , pp. 253-256
    • Frontini, A.1    Cinti, S.2
  • 19
    • 33845866857 scopus 로고    scopus 로고
    • Inflammation and metabolic disorders
    • Hotamisligil G.S. Inflammation and metabolic disorders. Nature 2006, 444:860-867.
    • (2006) Nature , vol.444 , pp. 860-867
    • Hotamisligil, G.S.1
  • 20
    • 77950343252 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress and the inflammatory basis of metabolic disease
    • Hotamisligil G.S. Endoplasmic reticulum stress and the inflammatory basis of metabolic disease. Cell 2010, 140:900-917.
    • (2010) Cell , vol.140 , pp. 900-917
    • Hotamisligil, G.S.1
  • 21
    • 0030061922 scopus 로고    scopus 로고
    • IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesity-induced insulin resistance
    • Hotamisligil G.S., Peraldi P., Budavari A., Ellis R., White M.F., Spiegelman B.M. IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesity-induced insulin resistance. Science 1996, 271:665-668.
    • (1996) Science , vol.271 , pp. 665-668
    • Hotamisligil, G.S.1    Peraldi, P.2    Budavari, A.3    Ellis, R.4    White, M.F.5    Spiegelman, B.M.6
  • 22
    • 77449117735 scopus 로고    scopus 로고
    • Depletion of liver Kupffer cells prevents the development of diet-induced hepatic steatosis and insulin resistance
    • Huang W., Metlakunta A., Dedousis N., Zhang P., Sipula I., Dube J.J., Scott D.K., O'Doherty R.M. Depletion of liver Kupffer cells prevents the development of diet-induced hepatic steatosis and insulin resistance. Diabetes 2010, 59:347-357.
    • (2010) Diabetes , vol.59 , pp. 347-357
    • Huang, W.1    Metlakunta, A.2    Dedousis, N.3    Zhang, P.4    Sipula, I.5    Dube, J.J.6    Scott, D.K.7    O'Doherty, R.M.8
  • 23
    • 0037928423 scopus 로고    scopus 로고
    • The role of energy availability in Mammalian hibernation: a cost-benefit approach
    • Humphries M.M., Thomas D.W., Kramer D.L. The role of energy availability in Mammalian hibernation: a cost-benefit approach. Physiol. Biochem. Zool. 2003, 76:165-179.
    • (2003) Physiol. Biochem. Zool. , vol.76 , pp. 165-179
    • Humphries, M.M.1    Thomas, D.W.2    Kramer, D.L.3
  • 24
    • 34548434020 scopus 로고    scopus 로고
    • Absence of CC chemokine ligand 2 does not limit obesity-associated infiltration of macrophages into adipose tissue
    • Inouye K.E., Shi H., Howard J.K., Daly C.H., Lord G.M., Rollins B.J., Flier J.S. Absence of CC chemokine ligand 2 does not limit obesity-associated infiltration of macrophages into adipose tissue. Diabetes 2007, 56:2242-2250.
    • (2007) Diabetes , vol.56 , pp. 2242-2250
    • Inouye, K.E.1    Shi, H.2    Howard, J.K.3    Daly, C.H.4    Lord, G.M.5    Rollins, B.J.6    Flier, J.S.7
  • 25
    • 84859997837 scopus 로고    scopus 로고
    • Activation of natural killer T cells promotes M2 Macrophage polarization in adipose tissue and improves systemic glucose tolerance via interleukin-4 (IL-4)/STAT6 protein signaling axis in obesity
    • Ji Y., Sun S., Xu A., Bhargava P., Yang L., Lam K.S., Gao B., Lee C.H., Kersten S., Qi L. Activation of natural killer T cells promotes M2 Macrophage polarization in adipose tissue and improves systemic glucose tolerance via interleukin-4 (IL-4)/STAT6 protein signaling axis in obesity. J. Biol. Chem. 2012, 287:13561-13571.
    • (2012) J. Biol. Chem. , vol.287 , pp. 13561-13571
    • Ji, Y.1    Sun, S.2    Xu, A.3    Bhargava, P.4    Yang, L.5    Lam, K.S.6    Gao, B.7    Lee, C.H.8    Kersten, S.9    Qi, L.10
  • 28
    • 44349112305 scopus 로고    scopus 로고
    • Adipocyte-derived Th2 cytokines and myeloid PPARdelta regulate macrophage polarization and insulin sensitivity
    • Kang K., Reilly S.M., Karabacak V., Gangl M.R., Fitzgerald K., Hatano B., Lee C.H. Adipocyte-derived Th2 cytokines and myeloid PPARdelta regulate macrophage polarization and insulin sensitivity. Cell Metab. 2008, 7:485-495.
    • (2008) Cell Metab. , vol.7 , pp. 485-495
    • Kang, K.1    Reilly, S.M.2    Karabacak, V.3    Gangl, M.R.4    Fitzgerald, K.5    Hatano, B.6    Lee, C.H.7
  • 29
    • 79956300649 scopus 로고    scopus 로고
    • Toll-like receptors and their crosstalk with other innate receptors in infection and immunity
    • Kawai T., Akira S. Toll-like receptors and their crosstalk with other innate receptors in infection and immunity. Immunity 2011, 34:637-650.
    • (2011) Immunity , vol.34 , pp. 637-650
    • Kawai, T.1    Akira, S.2
  • 30
    • 84869504451 scopus 로고    scopus 로고
    • Inflammasomes and their roles in health and disease
    • Lamkanfi M., Dixit V.M. Inflammasomes and their roles in health and disease. Annu. Rev. Cell Dev. Biol. 2012, 28:137-161.
    • (2012) Annu. Rev. Cell Dev. Biol. , vol.28 , pp. 137-161
    • Lamkanfi, M.1    Dixit, V.M.2
  • 31
    • 84859465056 scopus 로고    scopus 로고
    • In vivo identification of bipotential adipocyte progenitors recruited by β3-adrenoceptor activation and high-fat feeding
    • Lee Y.H., Petkova A.P., Mottillo E.P., Granneman J.G. In vivo identification of bipotential adipocyte progenitors recruited by β3-adrenoceptor activation and high-fat feeding. Cell Metab. 2012, 15:480-491.
    • (2012) Cell Metab. , vol.15 , pp. 480-491
    • Lee, Y.H.1    Petkova, A.P.2    Mottillo, E.P.3    Granneman, J.G.4
  • 32
    • 84867051812 scopus 로고    scopus 로고
    • IKKβ/NF-κB disrupts adult hypothalamic neural stem cells to mediate a neurodegenerative mechanism of dietary obesity and pre-diabetes
    • Li J., Tang Y., Cai D. IKKβ/NF-κB disrupts adult hypothalamic neural stem cells to mediate a neurodegenerative mechanism of dietary obesity and pre-diabetes. Nat. Cell Biol. 2012, 14:999-1012.
    • (2012) Nat. Cell Biol. , vol.14 , pp. 999-1012
    • Li, J.1    Tang, Y.2    Cai, D.3
  • 33
    • 79959962745 scopus 로고    scopus 로고
    • Hormonal regulation of hepatic glucose production in health and disease
    • Lin H.V., Accili D. Hormonal regulation of hepatic glucose production in health and disease. Cell Metab. 2011, 14:9-19.
    • (2011) Cell Metab. , vol.14 , pp. 9-19
    • Lin, H.V.1    Accili, D.2
  • 35
    • 0034611678 scopus 로고    scopus 로고
    • Towards a molecular understanding of adaptive thermogenesis
    • Lowell B.B., Spiegelman B.M. Towards a molecular understanding of adaptive thermogenesis. Nature 2000, 404:652-660.
    • (2000) Nature , vol.404 , pp. 652-660
    • Lowell, B.B.1    Spiegelman, B.M.2
  • 36
    • 33846026712 scopus 로고    scopus 로고
    • Obesity induces a phenotypic switch in adipose tissue macrophage polarization
    • Lumeng C.N., Bodzin J.L., Saltiel A.R. Obesity induces a phenotypic switch in adipose tissue macrophage polarization. J. Clin. Invest. 2007, 117:175-184.
    • (2007) J. Clin. Invest. , vol.117 , pp. 175-184
    • Lumeng, C.N.1    Bodzin, J.L.2    Saltiel, A.R.3
  • 37
    • 84866520055 scopus 로고    scopus 로고
    • Adipose tissue invariant NKT cells protect against diet-induced obesity and metabolic disorder through regulatory cytokine production
    • Lynch L., Nowak M., Varghese B., Clark J., Hogan A.E., Toxavidis V., Balk S.P., O'Shea D., O'Farrelly C., Exley M.A. Adipose tissue invariant NKT cells protect against diet-induced obesity and metabolic disorder through regulatory cytokine production. Immunity 2012, 37:574-587.
    • (2012) Immunity , vol.37 , pp. 574-587
    • Lynch, L.1    Nowak, M.2    Varghese, B.3    Clark, J.4    Hogan, A.E.5    Toxavidis, V.6    Balk, S.P.7    O'Shea, D.8    O'Farrelly, C.9    Exley, M.A.10
  • 38
    • 47949099098 scopus 로고    scopus 로고
    • Origin and physiological roles of inflammation
    • Medzhitov R. Origin and physiological roles of inflammation. Nature 2008, 454:428-435.
    • (2008) Nature , vol.454 , pp. 428-435
    • Medzhitov, R.1
  • 39
    • 0030831210 scopus 로고    scopus 로고
    • A human homologue of the Drosophila Toll protein signals activation of adaptive immunity
    • Medzhitov R., Preston-Hurlburt P., Janeway C.A. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature 1997, 388:394-397.
    • (1997) Nature , vol.388 , pp. 394-397
    • Medzhitov, R.1    Preston-Hurlburt, P.2    Janeway, C.A.3
  • 41
    • 75749108288 scopus 로고    scopus 로고
    • Double-stranded RNA-dependent protein kinase links pathogen sensing with stress and metabolic homeostasis
    • Nakamura T., Furuhashi M., Li P., Cao H., Tuncman G., Sonenberg N., Gorgun C.Z., Hotamisligil G.S. Double-stranded RNA-dependent protein kinase links pathogen sensing with stress and metabolic homeostasis. Cell 2010, 140:338-348.
    • (2010) Cell , vol.140 , pp. 338-348
    • Nakamura, T.1    Furuhashi, M.2    Li, P.3    Cao, H.4    Tuncman, G.5    Sonenberg, N.6    Gorgun, C.Z.7    Hotamisligil, G.S.8
  • 44
    • 84872576236 scopus 로고    scopus 로고
    • Metabolism of inflammation limited by AMPK and pseudo-starvation
    • O'Neill L.A., Hardie D.G. Metabolism of inflammation limited by AMPK and pseudo-starvation. Nature 2013, 493:346-355.
    • (2013) Nature , vol.493 , pp. 346-355
    • O'Neill, L.A.1    Hardie, D.G.2
  • 45
    • 77951146612 scopus 로고    scopus 로고
    • C-C chemokine receptor 2 (CCR2) regulates the hepatic recruitment of myeloid cells that promote obesity-induced hepatic steatosis
    • Obstfeld A.E., Sugaru E., Thearle M., Francisco A.M., Gayet C., Ginsberg H.N., Ables E.V., Ferrante A.W. C-C chemokine receptor 2 (CCR2) regulates the hepatic recruitment of myeloid cells that promote obesity-induced hepatic steatosis. Diabetes 2010, 59:916-925.
    • (2010) Diabetes , vol.59 , pp. 916-925
    • Obstfeld, A.E.1    Sugaru, E.2    Thearle, M.3    Francisco, A.M.4    Gayet, C.5    Ginsberg, H.N.6    Ables, E.V.7    Ferrante, A.W.8
  • 46
    • 84863577940 scopus 로고    scopus 로고
    • Leukocyte set points in metabolic disease
    • Odegaard J.I., Chawla A. Leukocyte set points in metabolic disease. F1000 Biol Rep 2012, 4:13.
    • (2012) F1000 Biol Rep , vol.4 , pp. 13
    • Odegaard, J.I.1    Chawla, A.2
  • 47
    • 84872166765 scopus 로고    scopus 로고
    • Pleiotropic actions of insulin resistance and inflammation in metabolic homeostasis
    • Odegaard J.I., Chawla A. Pleiotropic actions of insulin resistance and inflammation in metabolic homeostasis. Science 2013, 339:172-177.
    • (2013) Science , vol.339 , pp. 172-177
    • Odegaard, J.I.1    Chawla, A.2
  • 51
    • 84858710276 scopus 로고    scopus 로고
    • Kupffer cells ameliorate hepatic insulin resistance induced by high-fat diet rich in monounsaturated fatty acids: the evidence for the involvement of alternatively activated macrophages
    • Papackova Z., Palenickova E., Dankova H., Zdychova J., Skop V., Kazdova L., Cahova M. Kupffer cells ameliorate hepatic insulin resistance induced by high-fat diet rich in monounsaturated fatty acids: the evidence for the involvement of alternatively activated macrophages. Nutr. Metab. (Lond) 2012, 9:22.
    • (2012) Nutr. Metab. (Lond) , vol.9 , pp. 22
    • Papackova, Z.1    Palenickova, E.2    Dankova, H.3    Zdychova, J.4    Skop, V.5    Kazdova, L.6    Cahova, M.7
  • 52
    • 84876758617 scopus 로고    scopus 로고
    • Metabolic Pathways in Immune Cell Activation and Quiescence
    • this issue
    • Pearce E.L., Pearce E.J. Metabolic Pathways in Immune Cell Activation and Quiescence. Immunity 2013, 38:633-643. this issue.
    • (2013) Immunity , vol.38 , pp. 633-643
    • Pearce, E.L.1    Pearce, E.J.2
  • 54
    • 79960117277 scopus 로고    scopus 로고
    • Uncoupling the mechanisms of obesity and hypertension by targeting hypothalamic IKK-β and NF-κB
    • Purkayastha S., Zhang G., Cai D. Uncoupling the mechanisms of obesity and hypertension by targeting hypothalamic IKK-β and NF-κB. Nat. Med. 2011, 17:883-887.
    • (2011) Nat. Med. , vol.17 , pp. 883-887
    • Purkayastha, S.1    Zhang, G.2    Cai, D.3
  • 55
    • 34250773451 scopus 로고    scopus 로고
    • Mechanisms of obesity-associated insulin resistance: many choices on the menu
    • Qatanani M., Lazar M.A. Mechanisms of obesity-associated insulin resistance: many choices on the menu. Genes Dev. 2007, 21:1443-1455.
    • (2007) Genes Dev. , vol.21 , pp. 1443-1455
    • Qatanani, M.1    Lazar, M.A.2
  • 56
    • 84865472821 scopus 로고    scopus 로고
    • Tissue-specific insulin signaling, metabolic syndrome, and cardiovascular disease
    • Rask-Madsen C., Kahn C.R. Tissue-specific insulin signaling, metabolic syndrome, and cardiovascular disease. Arterioscler. Thromb. Vasc. Biol. 2012, 32:2052-2059.
    • (2012) Arterioscler. Thromb. Vasc. Biol. , vol.32 , pp. 2052-2059
    • Rask-Madsen, C.1    Kahn, C.R.2
  • 58
    • 33845864967 scopus 로고    scopus 로고
    • Adipocytes as regulators of energy balance and glucose homeostasis
    • Rosen E.D., Spiegelman B.M. Adipocytes as regulators of energy balance and glucose homeostasis. Nature 2006, 444:847-853.
    • (2006) Nature , vol.444 , pp. 847-853
    • Rosen, E.D.1    Spiegelman, B.M.2
  • 60
    • 84857861919 scopus 로고    scopus 로고
    • Mechanisms for insulin resistance: common threads and missing links
    • Samuel V.T., Shulman G.I. Mechanisms for insulin resistance: common threads and missing links. Cell 2012, 148:852-871.
    • (2012) Cell , vol.148 , pp. 852-871
    • Samuel, V.T.1    Shulman, G.I.2
  • 65
  • 66
    • 77953169046 scopus 로고    scopus 로고
    • Cellular bioenergetics as a target for obesity therapy
    • Tseng Y.H., Cypess A.M., Kahn C.R. Cellular bioenergetics as a target for obesity therapy. Nat. Rev. Drug Discov. 2010, 9:465-482.
    • (2010) Nat. Rev. Drug Discov. , vol.9 , pp. 465-482
    • Tseng, Y.H.1    Cypess, A.M.2    Kahn, C.R.3
  • 71
  • 72
    • 84858795360 scopus 로고    scopus 로고
    • Adaptive radiation of multituberculate mammals before the extinction of dinosaurs
    • Wilson G.P., Evans A.R., Corfe I.J., Smits P.D., Fortelius M., Jernvall J. Adaptive radiation of multituberculate mammals before the extinction of dinosaurs. Nature 2012, 483:457-460.
    • (2012) Nature , vol.483 , pp. 457-460
    • Wilson, G.P.1    Evans, A.R.2    Corfe, I.J.3    Smits, P.D.4    Fortelius, M.5    Jernvall, J.6
  • 76
    • 84873518501 scopus 로고    scopus 로고
    • Adaptive thermogenesis in adipocytes: is beige the new brown?
    • Wu J., Cohen P., Spiegelman B.M. Adaptive thermogenesis in adipocytes: is beige the new brown?. Genes Dev. 2013, 27:234-250.
    • (2013) Genes Dev. , vol.27 , pp. 234-250
    • Wu, J.1    Cohen, P.2    Spiegelman, B.M.3
  • 78
    • 0035979775 scopus 로고    scopus 로고
    • Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta
    • Yuan M., Konstantopoulos N., Lee J., Hansen L., Li Z.W., Karin M., Shoelson S.E. Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta. Science 2001, 293:1673-1677.
    • (2001) Science , vol.293 , pp. 1673-1677
    • Yuan, M.1    Konstantopoulos, N.2    Lee, J.3    Hansen, L.4    Li, Z.W.5    Karin, M.6    Shoelson, S.E.7
  • 79
    • 52949096557 scopus 로고    scopus 로고
    • Hypothalamic IKKbeta/NF-kappaB and ER stress link overnutrition to energy imbalance and obesity
    • Zhang X., Zhang G., Zhang H., Karin M., Bai H., Cai D. Hypothalamic IKKbeta/NF-kappaB and ER stress link overnutrition to energy imbalance and obesity. Cell 2008, 135:61-73.
    • (2008) Cell , vol.135 , pp. 61-73
    • Zhang, X.1    Zhang, G.2    Zhang, H.3    Karin, M.4    Bai, H.5    Cai, D.6


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