Dead adipocytes, detected as crown-like structures, are prevalent in visceral fat depots of genetically obese mice

Journal of Lipid Research

Volumn 49, Issue 7, 2008, Pages 1562-1568

  Murano, I ^a   Barbatelli, G ^a   Parisani, V ^a   Latini, C ^a   Muzzonigro, G ^a   Castellucci, M ^a   Cinti, S ^a  

^a UNIVERSITÀ POLITECNICA DELLE MARCHE   (Italy)

Author keywords

Adipocyte death; Macrophages; Obesity; Subcutaneous fat

Indexed keywords

ADIPOCYTE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DEATH; CELL DENSITY; CELL SIZE; CONTROLLED STUDY; DISORDERS OF CARBOHYDRATE METABOLISM; ELECTRON MICROSCOPY; FEMALE; IMMUNOHISTOCHEMISTRY; INTRAABDOMINAL FAT; MACROPHAGE; MORPHOMETRICS; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; SUBCUTANEOUS FAT; ANIMAL; CYTOLOGY; METABOLISM; MOUSE MUTANT;

ADIPOCYTES; ANIMALS; CELL DEATH; FEMALE; INTRA-ABDOMINAL FAT; MICE; MICE, OBESE;

EID: 50949108719     PISSN: 00222275     EISSN: 15397262     Source Type: Journal    
DOI: 10.1194/jlr.M800019-JLR200     Document Type: Article

References (28)

1. Bray, G. A., and T. Bellanger. 2006. Epidemiology, trends, and morbidities of obesity and the metabolic syndrome. Endocrine. 29: 109-117.
2. Hill, J. O. 2006. Understanding and addressing the epidemic of obesity: an energy balance perspective. Endocr. Rev. 27: 750-761.
3. Shetty, P., and J. Schmidhuber. 2006. Introductory lecture the epidemiology and determinants of obesity in developed and developing countries. Int. J. Vitam. Nutr. Res. 76: 157-162.
4. Kuk, J. L. 2007. Associations between abdominal adiposity, exercise, morbidity, and mortality. Appl. Physiol. Nutr. Metab. 32: 1210-1211.
5. Bjorntorp, P., and R. Rosmond. 1999. Visceral obesity and diabetes. Drugs. 58 (Suppl.): 13-18.
6. Rodriguez, A., V. Catalan, J. Gomez-Ambrosi, and G. Fruhbeck. 2007. Visceral and subcutaneous adiposity: are both potential therapeutic targets for tackling the metabolic syndrome? Curr. Pharm. Des. 13: 2169-2175.
7. Thorne, A., F. Lonnqvist, J. Apelman, G. Hellers, and P. Arner. 2002. A pilot study of long-term effects of a novel obesity treatment: omentectomy in connection with adjustable gastric banding. Int. J. Obes. Relat. Metab. Disord. 26: 193-199.
8. Frayn, K. N. 2000. Visceral fat and insulin resistance - causative or correlative? Br. J. Nutr. 83 (Suppl.): 71-77.
9. Wajchenberg, B. L. 2000. Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome. Endocr. Rev. 21: 697-738.
10. Weisberg, S. P., D. McCann, M. Desai, M. Rosenbaum, R. L. Leibel, and A. W. Ferrante, Jr. 2003. Obesity is associated with macrophage accumulation in adipose tissue. J. Clin. Invest. 112: 1796-1808.
11. Cinti, S., G. Mitchell, G. Barbatelli, I. Murano, E. Ceresi, E. Faloia, S. Wang, M. Fortier, A. S. Greenberg, and M. S. Obin. 2005. Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans. J. Lipid Res. 46: 2347-2355.
12. Yu, R., C. S. Kim, B. S. Kwon, and T. Kawada. 2006. Mesenteric adipose tissue-derived monocyte chemoattractant protein-1 plays a crucial role in adipose tissue macrophage migration and activation in obese mice. Obesity (Silver Spring). 14: 1353-1362.
13. Chen, A., S. Mumick, C. Zhang, J. Lamb, H. Dai, D. Weingarth, J. Mudgett, H. Chen, D. J. MacNeil, M. L. Reitman, et al. 2005. Diet induction of monocyte chemoattractant protein-1 and its impact on obesity. Obes. Res. 13: 1311-1320.
14. Cancello, R., S. Taleb, C. Poitou, J. Tordjman, D. Lacasa, M. Guerre-Millo, and K. Clement. 2006. [Is obesity an inflammatory disease?] Journ. Annu. Diabetol. Hotel Dieu. 115-128.
15. Lumeng, C. N., J. L. Bodzin, and A. R. Saltiel. 2007. Obesity induces a phenotypic switch in adipose tissue macrophage polarization. J. Clin. Invest. 117: 175-184.
16. Xu, H., G. T. Barnes, Q. Yang, G. Tan, D. Yang, C. J. Chou, J. Sole, A. Nichols, J. S. Ross, L. A. Tartaglia, et al. 2003. Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J. Clin. Invest. 112: 1821-1830.
17. Goossens, G. H. The role of adipose tissue dysfunction in the pathogenesis of obesity-related insulin resistance. Physiol. Behav. Epub ahead of print. October 22, 2007. doi: 10.1016/j.physbeh. 2007.10.010.
18. Strissel, K. J., Z. Stancheva, H. Miyoshi, J. W. Perfield 2nd, J. DeFuria, Z. Jick, A. S. Greenberg, and M. S. Obin. 2007. Adipocyte death, adipose tissue remodeling, and obesity complications. Diabetes. 56: 2910-2918.
19. Harman-Boehm, I., M. Bluher, H. Redel, N. Sion-Vardy, S. Ovadia, E. Avinoach, I. Shai, N. Kloting, M. Stumvoll, N. Bashan, et al. 2007. Macrophage infiltration into omental versus subcutaneous fat across different populations: effect of regional adiposity and the comorbidities of obesity. J. Clin. Endocrinol. Metab. 92: 2240-2247.
20. Crossno, J. T., Jr., S. M. Majka, T. Grazia, R. G. Gill, and D. J. Klemm. 2006. Rosiglitazone promotes development of a novel adipocyte population from bone marrow-derived circulating progenitor cells. J. Clin. Invest. 116: 3220-3228.
21. Zhang, J., W. Wright, D. A. Bernlohr, S. W. Cushman, and X. Chen. 2007. Alterations of the classic pathway of complement in adipose tissue of obesity and insulin resistance. Am. J. Physiol. Endocrinol. Metab. 292: E1433-E1440.
22. Bastard, J. P., M. Maachi, C. Lagathu, M. J. Kim, M. Caron, H. Vidal, J. Capeau, and B. Feve. 2006. Recent advances in the relationship between obesity, inflammation, and insulin resistance. Eur. Cytokine Netw. 17: 4-12.
23. Cartwright, M. J., T. Tchkonia, and J. L. Kirkland. 2007. Aging in adipocytes: potential impact of inherent, depot-specific mechanisms. Exp. Gerontol. 42: 463-471.
24. Wajchenberg, B. L., D. Giannella-Neto, M. E. da Silva, and R. F. Santos. 2002. Depot-specific hormonal characteristics of subcutaneous and visceral adipose tissue and their relation to the metabolic syndrome. Horm. Metab. Res. 34: 616-621.
25. Johnson, P. R., and J. Hirsch. 1972. Cellularity of adipose depots in six strains of genetically obese mice. J. Lipid Res. 13: 2-11.
26. Stern, J. S., B. R. Batchelor, N. Hollander, C. K. Cohn, and J. Hirsch. 1972. Adipose-cell size and immunoreactive insulin levels in obese and normal-weight adults. Lancet. 2: 948-951.
27. Hausman, D. B., M. DiGirolamo, T. J. Bartness, G. J. Hausman, and R. J. Martin. 2001. The biology of white adipocyte proliferation. Obes. Rev. 2: 239-254.
28. Garris, D. R., and B. L. Garris. 2004. Genomic modulation of diabetes (db/db) and obese (ob/ob) mutation-induced hypercytolipidemia: cytochemical basis of female reproductive tract involution. Cell Tissue Res. 316: 233-241.