-
1
-
-
0035976638
-
Nuclear receptors and lipid physiology: Opening the x-files
-
DOI 10.1126/science.294.5548.1866
-
Chawla, A., Repa, J., Evans, R. & Mangelsdorf, D. Nuclear receptors and lipid physiology: opening the X-files. Science 294, 1866-1870 (2001). (Pubitemid 33101573)
-
(2001)
Science
, vol.294
, Issue.5548
, pp. 1866-1870
-
-
Chawta, A.1
Repa, J.J.2
Evans, R.M.3
Mangelsdorf, D.J.4
-
2
-
-
0012473279
-
The nuclear receptor superfamily: The second decade
-
Mangelsdorf, D. J. et al. The nuclear receptor superfamily: the second decade. Cell 83, 835-839 (1995).
-
(1995)
Cell
, vol.83
, pp. 835-839
-
-
Mangelsdorf, D.J.1
-
3
-
-
84958107344
-
The effect of a hormone of the adrenal cortex (17-hydroxyl-11- dehydrocortisone: Compound E) and of pituitary adrenocorticotropic hormone on rheumatoid arthritis
-
Hench, P., Kendall, E., Slocumb, C. & Polley, H. The effect of a hormone of the adrenal cortex (17-hydroxyl-11-dehydrocortisone: compound E) and of pituitary adrenocorticotropic hormone on rheumatoid arthritis. Proc. Staff Meet. Mayo Clin. 24, 181-197 (1948).
-
(1948)
Proc. Staff Meet. Mayo Clin.
, vol.24
, pp. 181-197
-
-
Hench, P.1
Kendall, E.2
Slocumb, C.3
Polley, H.4
-
4
-
-
33244482536
-
Combinatorial roles of nuclear receptors in inflammation and immunity
-
Glass, C. K. & Ogawa, S. Combinatorial roles of nuclear receptors in inflammation and immunity. Nature Rev. Immunol. 6, 44-55 (2006).
-
(2006)
Nature Rev. Immunol.
, vol.6
, pp. 44-55
-
-
Glass, C.K.1
Ogawa, S.2
-
5
-
-
34547902854
-
Glucocorticoids and the innate immune system: Crosstalk with the Toll-like receptor signaling network
-
Chinenov, Y. & Rogatsky, I. Glucocorticoids and the innate immune system: crosstalk with the Toll-like receptor signaling network. Mol. Cell. Endocrinol. 275, 30-42 (2007).
-
(2007)
Mol. Cell. Endocrinol.
, vol.275
, pp. 30-42
-
-
Chinenov, Y.1
Rogatsky, I.2
-
6
-
-
65349172388
-
Transcriptional regulatory networks in Th17 cell differentiation
-
Zhou, L. & Littman, D. R. Transcriptional regulatory networks in Th17 cell differentiation. Curr. Opin. Immunol. 21, 146-152 (2009).
-
(2009)
Curr. Opin. Immunol.
, vol.21
, pp. 146-152
-
-
Zhou, L.1
Littman, D.R.2
-
7
-
-
0035524488
-
Toll-like receptors and innate immunity
-
Medzhitov, R. Toll-like receptors and innate immunity. Nature Rev. Immunol. 1, 135-145 (2001).
-
(2001)
Nature Rev. Immunol.
, vol.1
, pp. 135-145
-
-
Medzhitov, R.1
-
9
-
-
33750369226
-
Toll-like receptors in systemic autoimmune disease
-
Marshak-Rothstein, A. Toll-like receptors in systemic autoimmune disease. Nature Rev. Immunol. 6, 823-835 (2006).
-
(2006)
Nature Rev. Immunol.
, vol.6
, pp. 823-835
-
-
Marshak-Rothstein, A.1
-
10
-
-
20144385204
-
Toll-like receptor 4-dependent and-independent cytokine secretion induced by minimally oxidized low-density lipoprotein in macrophages
-
Miller, Y. I. et al. Toll-like receptor 4-dependent and-independent cytokine secretion induced by minimally oxidized low-density lipoprotein in macrophages. Arterioscler. Thromb. Vasc. Biol. 25, 1213-1219 (2005).
-
(2005)
Arterioscler. Thromb. Vasc. Biol.
, vol.25
, pp. 1213-1219
-
-
Miller, Y.I.1
-
11
-
-
33750584214
-
TLR4 links innate immunity and fatty acid-induced insulin resistance
-
Shi, H. et al. TLR4 links innate immunity and fatty acid-induced insulin resistance. J. Clin. Invest. 11 6, 3015-3025 (2006).
-
(2006)
J. Clin. Invest.
, vol.11
, Issue.6
, pp. 3015-3025
-
-
Shi, H.1
-
12
-
-
36849005372
-
A subpopulation of macrophages infiltrates hypertrophic adipose tissue and is activated by free fatty acids via Toll-like receptors 2 and 4 and JNK-dependent pathways
-
Nguyen, M. T. et al. A subpopulation of macrophages infiltrates hypertrophic adipose tissue and is activated by free fatty acids via Toll-like receptors 2 and 4 and JNK-dependent pathways. J. Biol. Chem. 282, 35279-35292 (2007).
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 35279-35292
-
-
Nguyen, M.T.1
-
13
-
-
35848963223
-
Role of the Toll-like receptor 4 in neuroinflammation in Alzheimer's disease
-
Walter, S. et al. Role of the Toll-like receptor 4 in neuroinflammation in Alzheimer's disease. Cell Physiol. Biochem. 20, 947-956 (2007).
-
(2007)
Cell Physiol. Biochem.
, vol.20
, pp. 947-956
-
-
Walter, S.1
-
14
-
-
34250169823
-
Toll-like receptor-4 mediates vascular inflammation and insulin resistance in diet-induced obesity
-
Kim, F. et al. Toll-like receptor-4 mediates vascular inflammation and insulin resistance in diet-induced obesity. Circ. Res. 100, 1589-1596 (2007).
-
(2007)
Circ. Res.
, vol.100
, pp. 1589-1596
-
-
Kim, F.1
-
15
-
-
3242710174
-
Lack of Toll-like receptor 4 or myeloid differentiation factor 88 reduces atherosclerosis and alters plaque phenotype in mice deficient in apolipoprotein e
-
Michelsen, K. S. et al. Lack of Toll-like receptor 4 or myeloid differentiation factor 88 reduces atherosclerosis and alters plaque phenotype in mice deficient in apolipoprotein E. Proc. Natl Acad. Sci. USA 101, 10679-10684 (2004).
-
(2004)
Proc. Natl Acad. Sci. USA
, vol.101
, pp. 10679-10684
-
-
Michelsen, K.S.1
-
16
-
-
27644568878
-
Modulation of atherosclerosis in mice by Toll-like receptor 2
-
Mullick, A. E., Tobias, P. S. & Curtiss, L. K. Modulation of atherosclerosis in mice by Toll-like receptor 2. J. Clin. Invest. 11 5, 3149-3156 (2005).
-
(2005)
J. Clin. Invest.
, vol.11
, Issue.5
, pp. 3149-3156
-
-
Mullick, A.E.1
Tobias, P.S.2
Curtiss, L.K.3
-
17
-
-
34247884376
-
C3H/HeJ mice carrying a Toll-like receptor 4 mutation are protected against the development of insulin resistance in white adipose tissue in response to a high-fat diet
-
Poggi, M. et al. C3H/HeJ mice carrying a Toll-like receptor 4 mutation are protected against the development of insulin resistance in white adipose tissue in response to a high-fat diet. Diabetologia 50, 1267-1276 (2007).
-
(2007)
Diabetologia
, vol.50
, pp. 1267-1276
-
-
Poggi, M.1
-
18
-
-
70350389389
-
Hematopoietic cell-specific deletion of Toll-like receptor 4 ameliorates hepatic and adipose tissue insulin resistance in high-fat-fed mice
-
Saberi, M. et al. Hematopoietic cell-specific deletion of Toll-like receptor 4 ameliorates hepatic and adipose tissue insulin resistance in high-fat-fed mice. Cell Metab. 10, 419-429 (2009).
-
(2009)
Cell Metab.
, vol.10
, pp. 419-429
-
-
Saberi, M.1
-
19
-
-
3142724031
-
Toll-like receptor signalling
-
Akira, S. & Takeda, K. Toll-like receptor signalling. Nature Rev. Immunol. 4, 499-511 (2004).
-
(2004)
Nature Rev. Immunol.
, vol.4
, pp. 499-511
-
-
Akira, S.1
Takeda, K.2
-
20
-
-
17644402442
-
Type i interferons (α/β) in immunity and autoimmunity
-
Theofilopoulos, A. N., Baccala, R., Beutler, B. & Kono, D. H. Type I interferons (α/β) in immunity and autoimmunity. Annu. Rev. Immunol. 23, 307-336 (2005).
-
(2005)
Annu. Rev. Immunol.
, vol.23
, pp. 307-336
-
-
Theofilopoulos, A.N.1
Baccala, R.2
Beutler, B.3
Kono, D.H.4
-
21
-
-
24944489952
-
Stimulus specificity of gene expression programs determined by temporal control of IKK activity
-
Werner, S. L., Barken, D. & Hoffmann, A. Stimulus specificity of gene expression programs determined by temporal control of IKK activity. Science 309, 1857-1861 (2005).
-
(2005)
Science 309
, pp. 1857-1861
-
-
Werner, S.L.1
Barken, D.2
Hoffmann, A.3
-
22
-
-
0037144591
-
Defining requirements for heterodimerization between the retinoid X receptor and the orphan nuclear receptor Nurr1
-
Aarnisalo, P., Kim, C. H., Lee, J. W. & Perlmann, T. Defining requirements for heterodimerization between the retinoid X receptor and the orphan nuclear receptor Nurr1. J. Biol. Chem. 277, 35118-35123 (2002).
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 35118-35123
-
-
Aarnisalo, P.1
Kim, C.H.2
Lee, J.W.3
Perlmann, T.4
-
23
-
-
0032747825
-
Heterodimerization between members of the Nur subfamily of orphan nuclear receptors as a novel mechanism for gene activation
-
Maira, M., Martens, C., Philips, A. & Drouin, J. Heterodimerization between members of the Nur subfamily of orphan nuclear receptors as a novel mechanism for gene activation. Mol. Cell. Biol. 19, 7549-7557 (1999).
-
(1999)
Mol. Cell. Biol.
, vol.19
, pp. 7549-7557
-
-
Maira, M.1
Martens, C.2
Philips, A.3
Drouin, J.4
-
24
-
-
0038526314
-
Structure and function of Nurr1 identifies a class of ligand-independent nuclear receptors
-
Wang, Z. et al. Structure and function of Nurr1 identifies a class of ligand-independent nuclear receptors. Nature 423, 555-560 (2003).
-
(2003)
Nature
, vol.423
, pp. 555-560
-
-
Wang, Z.1
-
25
-
-
33744792310
-
Sensors and signals: A coactivator/corepressor/epigenetic code for integrating signal-dependent programs of transcriptional response
-
Rosenfeld, M. G., Lunyak, V. V. & Glass, C. K. Sensors and signals: a coactivator/corepressor/epigenetic code for integrating signal-dependent programs of transcriptional response. Genes Dev. 20, 1405-1428 (2006).
-
(2006)
Genes Dev.
, vol.20
, pp. 1405-1428
-
-
Rosenfeld, M.G.1
Lunyak, V.V.2
Glass, C.K.3
-
26
-
-
44649170303
-
Cracking the coregulator codes
-
O'Malley, B. W., Qin, J. & Lanz, R. B. Cracking the coregulator codes. Curr. Opin. Cell Biol. 20, 310-315 (2008).
-
(2008)
Curr. Opin. Cell Biol.
, vol.20
, pp. 310-315
-
-
O'Malley, B.W.1
Qin, J.2
Lanz, R.B.3
-
27
-
-
0037324340
-
Reciprocal regulation of inflammation and lipid metabolism by liver X receptors
-
Joseph, S. B., Castrillo, A., Laffitte, B. A., Mangelsdorf, D. J. & Tontonoz, P. Reciprocal regulation of inflammation and lipid metabolism by liver X receptors. Nature Med. 9, 213-219 (2003).
-
(2003)
Nature Med.
, vol.9
, pp. 213-219
-
-
Joseph, S.B.1
Castrillo, A.2
Laffitte, B.A.3
Mangelsdorf, D.J.4
Tontonoz, P.5
-
28
-
-
44349161098
-
Alternative M2 activation of Kupffer cells by PPARδ ameliorates obesity-induced insulin resistance
-
Odegaard, J. I. et al. Alternative M2 activation of Kupffer cells by PPARδ ameliorates obesity-induced insulin resistance. Cell Metab. 7, 496-507 (2008).
-
(2008)
Cell Metab.
, vol.7
, pp. 496-507
-
-
Odegaard, J.I.1
-
29
-
-
40849085514
-
FoxA1 translates epigenetic signatures into enhancer-driven lineage-specific transcription
-
Lupien, M. et al. FoxA1 translates epigenetic signatures into enhancer-driven lineage-specific transcription. Cell 132, 958-970 (2008).
-
(2008)
Cell
, vol.132
, pp. 958-970
-
-
Lupien, M.1
-
30
-
-
22144486551
-
Chromosome-wide mapping of estrogen receptor binding reveals long-range regulation requiring the forkhead protein FoxA1
-
Carroll, J. S. et al. Chromosome-wide mapping of estrogen receptor binding reveals long-range regulation requiring the forkhead protein FoxA1. Cell 122, 33-43 (2005).
-
(2005)
Cell
, vol.122
, pp. 33-43
-
-
Carroll, J.S.1
-
31
-
-
55749095056
-
PPARγ and C/EBP factors orchestrate adipocyte biology via adjacent binding on a genome-wide scale
-
Lefterova, M. I. et al. PPARγ and C/EBP factors orchestrate adipocyte biology via adjacent binding on a genome-wide scale. Genes Dev. 22, 2941-2952 (2008).
-
(2008)
Genes Dev.
, vol.22
, pp. 2941-2952
-
-
Lefterova, M.I.1
-
32
-
-
55749101777
-
Genome-wide profiling of PPARγ:RXR and RNA polymerase II occupancy reveals temporal activation of distinct metabolic pathways and changes in RXR dimer composition during adipogenesis
-
Nielsen, R. et al. Genome-wide profiling of PPARγ:RXR and RNA polymerase II occupancy reveals temporal activation of distinct metabolic pathways and changes in RXR dimer composition during adipogenesis. Genes Dev. 22, 2953-2967 (2008).
-
(2008)
Genes Dev.
, vol.22
, pp. 2953-2967
-
-
Nielsen, R.1
-
33
-
-
33748588423
-
+ T helper cells
-
+ T helper cells. Cell 126, 1121-1133 (2006).
-
(2006)
Cell
, vol.126
, pp. 1121-1133
-
-
Ivanov, I.I.1
-
34
-
-
61949463911
-
IL-17 and Th17 cells
-
Korn, T., Bettelli, E., Oukka, M. & Kuchroo, V. K. IL-17 and Th17 cells. Annu. Rev. Immunol. 27, 485-517 (2009).
-
(2009)
Annu. Rev. Immunol.
, vol.27
, pp. 485-517
-
-
Korn, T.1
Bettelli, E.2
Oukka, M.3
Kuchroo, V.K.4
-
35
-
-
25444448223
-
A nuclear receptor atlas: Macrophage activation
-
Barish, G. D. et al. A nuclear receptor atlas: macrophage activation. Mol. Endocrinol. 19, 2466-2477 (2005).
-
(2005)
Mol. Endocrinol.
, vol.19
, pp. 2466-2477
-
-
Barish, G.D.1
-
36
-
-
33747154772
-
Anatomical profiling of nuclear receptor expression reveals a hierarchical transcriptional network
-
Bookout, A. L. et al. Anatomical profiling of nuclear receptor expression reveals a hierarchical transcriptional network. Cell 126, 789-799 (2006).
-
(2006)
Cell
, vol.126
, pp. 789-799
-
-
Bookout, A.L.1
-
37
-
-
24144465889
-
Molecular determinants of crosstalk between nuclear receptors and Toll-like receptors
-
Ogawa, S. et al. Molecular determinants of crosstalk between nuclear receptors and Toll-like receptors. Cell 122, 707-721 (2005).
-
(2005)
Cell
, vol.122
, pp. 707-721
-
-
Ogawa, S.1
-
38
-
-
0041324898
-
The interplay between the glucocorticoid receptor and nuclear factor-κB or activator protein-1: Molecular mechanisms for gene repression
-
De Bosscher, K., Vanden Berghe, W. & Haegeman, G. The interplay between the glucocorticoid receptor and nuclear factor-κB or activator protein-1: molecular mechanisms for gene repression. Endocr. Rev. 24, 488-522 (2003).
-
(2003)
Endocr. Rev.
, vol.24
, pp. 488-522
-
-
De Bosscher, K.1
Vanden Berghe, W.2
Haegeman, G.3
-
39
-
-
48649103130
-
Corticosteroids reduce IL-6 in ASM cells via up-regulation of MKP-1
-
Quante, T. et al. Corticosteroids reduce IL-6 in ASM cells via up-regulation of MKP-1. Am. J. Respir. Cell Mol. Biol. 39, 208-217 (2008).
-
(2008)
Am. J. Respir. Cell Mol. Biol.
, vol.39
, pp. 208-217
-
-
Quante, T.1
-
40
-
-
47049117420
-
Altered subcellular distribution of MSK1 induced by glucocorticoids contributes to NF-κB inhibition
-
Beck, I. M. et al. Altered subcellular distribution of MSK1 induced by glucocorticoids contributes to NF-κB inhibition. EMBO J. 27, 1682-1693 (2008).
-
(2008)
EMBO J.
, vol.27
, pp. 1682-1693
-
-
Beck, I.M.1
-
41
-
-
58149235153
-
A novel mitogen-activated protein kinase phosphatase-1 and glucocorticoid receptor (GR) interacting protein-1-dependent combinatorial mechanism of gene transrepression by GR
-
Cho, I. J. & Kim, S. G. A novel mitogen-activated protein kinase phosphatase-1 and glucocorticoid receptor (GR) interacting protein-1-dependent combinatorial mechanism of gene transrepression by GR. Mol. Endocrinol. 23, 86-99 (2009).
-
(2009)
Mol. Endocrinol.
, vol.23
, pp. 86-99
-
-
Cho, I.J.1
Kim, S.G.2
-
42
-
-
48249111889
-
Restriction to Fos family members of Trip6-dependent coactivation and glucocorticoid receptor-dependent trans-repression of activator protein-1
-
Diefenbacher, M. et al. Restriction to Fos family members of Trip6-dependent coactivation and glucocorticoid receptor-dependent trans-repression of activator protein-1. Mol. Endocrinol. 22, 1767-1780 (2008).
-
(2008)
Mol. Endocrinol.
, vol.22
, pp. 1767-1780
-
-
Diefenbacher, M.1
-
43
-
-
61449229273
-
Latest perspectives on antiinflammatory actions of glucocorticoids
-
De Bosscher, K. & Haegeman, G. Minireview: latest perspectives on antiinflammatory actions of glucocorticoids. Mol. Endocrinol. 23, 281-291 (2009).
-
(2009)
Mol. Endocrinol.
, vol.23
, pp. 281-291
-
-
De Bosscher, K.1
Minireview, H.G.2
-
44
-
-
4644252538
-
One nucleotide in a κb site can determine cofactor specificity for NF-κB dimers
-
Leung, T. H., Hoffmann, A. & Baltimore, D. One nucleotide in a κB site can determine cofactor specificity for NF-κB dimers. Cell 11 8, 453-464 (2004).
-
(2004)
Cell
, vol.11
, Issue.8
, pp. 453-464
-
-
Leung, T.H.1
Hoffmann, A.2
Baltimore, D.3
-
45
-
-
18244381020
-
The glucocorticoid receptor blocks P-TEFb recruitment by NFκB to effect promoter-specific transcriptional repression
-
Luecke, H. F. & Yamamoto, K. R. The glucocorticoid receptor blocks P-TEFb recruitment by NFκB to effect promoter-specific transcriptional repression. Genes Dev. 19, 1116-1127 (2005).
-
(2005)
Genes Dev.
, vol.19
, pp. 1116-1127
-
-
Luecke, H.F.1
Yamamoto, K.R.2
-
46
-
-
67649648237
-
Control of inducible gene expression by signal-dependent transcriptional elongation
-
Hargreaves, D. C., Horng, T. & Medzhitov, R. Control of inducible gene expression by signal-dependent transcriptional elongation. Cell 138, 129-145 (2009).
-
(2009)
Cell
, vol.138
, pp. 129-145
-
-
Hargreaves, D.C.1
Horng, T.2
Medzhitov, R.3
-
47
-
-
0037168648
-
Alternate surfaces of transcriptional coregulator GRIP1 function in different glucocorticoid receptor activation and repression contexts
-
Rogatsky, I., Luecke, H. F., Leitman, D. C. & Yamamoto, K. R. Alternate surfaces of transcriptional coregulator GRIP1 function in different glucocorticoid receptor activation and repression contexts. Proc. Natl Acad. Sci. USA 99, 16701-16706 (2002).
-
(2002)
Proc. Natl Acad. Sci. USA
, vol.99
, pp. 16701-16706
-
-
Rogatsky, I.1
Luecke, H.F.2
Leitman, D.C.3
Yamamoto, K.R.4
-
48
-
-
0035502975
-
Factor recruitment and TIF2/GRIP1 corepressor activity at a collagenase-3 response element that mediates regulation by phorbol esters and hormones
-
Rogatsky, I., Zarember, K. A. & Yamamoto, K. R. Factor recruitment and TIF2/GRIP1 corepressor activity at a collagenase-3 response element that mediates regulation by phorbol esters and hormones. EMBO J. 20, 6071-6083 (2001).
-
(2001)
EMBO J.
, vol.20
, pp. 6071-6083
-
-
Rogatsky, I.1
Zarember, K.A.2
Yamamoto, K.R.3
-
49
-
-
5444233785
-
A nuclear isoform of the focal adhesion LIM-domain protein Trip6 integrates activating and repressing signals at AP-1-and NF-κB-regulated promoters
-
Kassel, O. et al. A nuclear isoform of the focal adhesion LIM-domain protein Trip6 integrates activating and repressing signals at AP-1-and NF-κB-regulated promoters. Genes Dev. 18, 2518-2528 (2004).
-
(2004)
Genes Dev.
, vol.18
, pp. 2518-2528
-
-
Kassel, O.1
-
50
-
-
5144232850
-
A nuclear receptor corepressor transcriptional checkpoint controlling activator protein 1-dependent gene networks required for macrophage activation
-
Ogawa, S. et al. A nuclear receptor corepressor transcriptional checkpoint controlling activator protein 1-dependent gene networks required for macrophage activation. Proc. Natl Acad. Sci. USA 101, 14461-14466 (2004).
-
(2004)
Proc. Natl Acad. Sci. USA
, vol.101
, pp. 14461-14466
-
-
Ogawa, S.1
-
51
-
-
26444471700
-
A SUMOylation-dependent pathway mediates transrepression of inflammatory response genes by PPAR-y
-
Pascual, G. et al. A SUMOylation-dependent pathway mediates transrepression of inflammatory response genes by PPAR-y. Nature 437, 759-763 (2005).
-
(2005)
Nature
, vol.437
, pp. 759-763
-
-
Pascual, G.1
-
52
-
-
0029097233
-
A transcriptional co-repressor that interacts with nuclear hormone receptors
-
Chen, J. D. & Evans, R. M. A transcriptional co-repressor that interacts with nuclear hormone receptors. Nature 377, 454-457 (1995).
-
(1995)
Nature
, vol.377
, pp. 454-457
-
-
Chen, J.D.1
Evans, R.M.2
-
53
-
-
0029132202
-
L igand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor
-
Horlein, A. J. et al. L igand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor. Nature 377, 397-404 (1995).
-
(1995)
Nature
, vol.377
, pp. 397-404
-
-
Horlein, A.J.1
-
54
-
-
0037084392
-
Biological roles and mechanistic actions of co-repressor complexes
-
Jepsen, K. & Rosenfeld, M. G. Biological roles and mechanistic actions of co-repressor complexes. J. Cell Sci. 115, 689-698 (2002).
-
(2002)
J. Cell Sci.
, vol.115
, pp. 689-698
-
-
Jepsen, K.1
Rosenfeld, M.G.2
-
55
-
-
63049122784
-
Cooperative NCoR/SMRT interactions establish a corepressor-based strategy for integration of inflammatory and anti-inflammatory signaling pathways
-
Ghisletti, S. et al. Cooperative NCoR/SMRT interactions establish a corepressor-based strategy for integration of inflammatory and anti-inflammatory signaling pathways. Genes Dev. 23, 681-693 (2009).
-
(2009)
Genes Dev.
, vol.23
, pp. 681-693
-
-
Ghisletti, S.1
-
56
-
-
1342264315
-
A corepressor/coactivator exchange complex required for transcriptional activation by nuclear receptors and other regulated transcription factors
-
Perissi, V., Aggarwal, A., Glass, C. K., Rose, D. W. & Rosenfeld, M. G. A corepressor/coactivator exchange complex required for transcriptional activation by nuclear receptors and other regulated transcription factors. Cell 116, 511-526 (2004).
-
(2004)
Cell
, vol.116
, pp. 511-526
-
-
Perissi, V.1
Aggarwal, A.2
Glass, C.K.3
Rose, D.W.4
Rosenfeld, M.G.5
-
57
-
-
24944555648
-
Estrogen down-regulation of the corepressor N-CoR: Mechanism and implications for estrogen derepression of N-CoR-regulated genes
-
Frasor, J., Danes, J. M., Funk, C. C. & Katzenellenbogen, B. S. Estrogen down-regulation of the corepressor N-CoR: mechanism and implications for estrogen derepression of N-CoR-regulated genes. Proc. Natl Acad. Sci. USA 102, 13153-13157 (2005).
-
(2005)
Proc. Natl Acad. Sci. USA
, vol.102
, pp. 13153-13157
-
-
Frasor, J.1
Danes, J.M.2
Funk, C.C.3
Katzenellenbogen, B.S.4
-
58
-
-
33845970925
-
Parallel SUMOylation-dependent pathways mediate gene-and signal-specific transrepression by LXRs and PPARy
-
Ghisletti, S. et al. Parallel SUMOylation-dependent pathways mediate gene-and signal-specific transrepression by LXRs and PPARy. Mol. Cell 25, 57-70 (2007).
-
(2007)
Mol. Cell
, vol.25
, pp. 57-70
-
-
Ghisletti, S.1
-
59
-
-
33845635077
-
A nuclear receptor corepressor-dependent pathway mediates suppression of cytokine-induced C-reactive protein gene expression by liver X receptor
-
Blaschke, F et al. A nuclear receptor corepressor-dependent pathway mediates suppression of cytokine-induced C-reactive protein gene expression by liver X receptor. Circ. Res. 99, e88-e99 (2006).
-
(2006)
Circ. Res.
, vol.99
-
-
Blaschke, F.1
-
60
-
-
76749125430
-
GPS2-dependent corepressor/SUMO pathways govern anti-inflammatory actions of LRH-1 and LXRß in the hepatic acute phase response
-
Venteclef, N. et al. GPS2-dependent corepressor/SUMO pathways govern anti-inflammatory actions of LRH-1 and LXRß in the hepatic acute phase response. Genes Dev. 24, 381-395 (2010).
-
(2010)
Genes Dev.
, vol.24
, pp. 381-395
-
-
Venteclef, N.1
-
61
-
-
67649668789
-
Transcriptional integration of TLR2 and TLR4 signaling at the NCoR depresssion checkpoint
-
Huang, W., Ghisletti, S., Perissi, V., Rosenfeld, M. G. & Glass, C. K. Transcriptional integration of TLR2 and TLR4 signaling at the NCoR depresssion checkpoint. Mol. Cell 10, 48-57 (2009).
-
(2009)
Mol. Cell
, vol.10
, pp. 48-57
-
-
Huang, W.1
Ghisletti, S.2
Perissi, V.3
Rosenfeld, M.G.4
Glass, C.K.5
-
62
-
-
0033838465
-
The SMRT corepressor is regulated by a MEK-1 kinase pathway: Inhibition of corepressor function is associated with SMRT phosphorylation and nuclear export
-
Hong, S. H. & Privalsky, M. L. The SMRT corepressor is regulated by a MEK-1 kinase pathway: inhibition of corepressor function is associated with SMRT phosphorylation and nuclear export. Mol. Cell. Biol. 20, 6612-6625 (2000).
-
(2000)
Mol. Cell. Biol.
, vol.20
, pp. 6612-6625
-
-
Hong, S.H.1
Privalsky, M.L.2
-
63
-
-
11144230050
-
SMRT and N-CoR corepressors are regulated by distinct kinase signaling pathways
-
Jonas, B. A. & Privalsky, M. L. SMRT and N-CoR corepressors are regulated by distinct kinase signaling pathways. J. Biol. Chem. 279, 54676-54686 (2004).
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 54676-54686
-
-
Jonas, B.A.1
Privalsky, M.L.2
-
64
-
-
0037062498
-
MEKK1 plays a critical role in activating the transcription factor C/EBP-ß-dependent gene expression in response to IFN-y
-
Roy, S. K. et al. MEKK1 plays a critical role in activating the transcription factor C/EBP-ß-dependent gene expression in response to IFN-y. Proc. Natl Acad. Sci. USA 99, 7945-7950 (2002).
-
(2002)
Proc. Natl Acad. Sci. USA
, vol.99
, pp. 7945-7950
-
-
Roy, S.K.1
-
65
-
-
36248990248
-
SMRT-mediated repression of an H3K27 demethylase in progression from neural stem cell to neuron
-
Jepsen, K. et al. SMRT-mediated repression of an H3K27 demethylase in progression from neural stem cell to neuron. Nature 450, 415-419 (2007).
-
(2007)
Nature
, vol.450
, pp. 415-419
-
-
Jepsen, K.1
-
66
-
-
70349191359
-
Differential SUMOylation of LXRα and LXRß mediates transrepression of STAT1 inflammatory signaling in IFN-y-stimulated brain astrocytes
-
Lee, J. H. et al. Differential SUMOylation of LXRα and LXRß mediates transrepression of STAT1 inflammatory signaling in IFN-y-stimulated brain astrocytes. Mol. Cell 35, 806-817 (2009).
-
(2009)
Mol. Cell
, vol.35
, pp. 806-817
-
-
Lee, J.H.1
-
67
-
-
63049083734
-
A Nurr1/CoREST pathway in microglia and astrocytes protects dopaminergic neurons from inflammation-induced death
-
Saijo, K. et al. A Nurr1/CoREST pathway in microglia and astrocytes protects dopaminergic neurons from inflammation-induced death. Cell 137, 47-59 (2009).
-
(2009)
Cell
, vol.137
, pp. 47-59
-
-
Saijo, K.1
-
68
-
-
9644262497
-
Phosphorylation of serine 468 by GSK-3ß negatively regulates basal p65 NF-?B activity
-
Buss, H. et al. Phosphorylation of serine 468 by GSK-3ß negatively regulates basal p65 NF-?B activity. J. Biol. Chem. 279, 49571-49574 (2004).
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 49571-49574
-
-
Buss, H.1
-
69
-
-
0034049874
-
Glucocorticoids in T cell development and function
-
Ashwell, J. D., Lu, F W. & Vacchio, M. S. Glucocorticoids in T cell development and function. Annu. Rev. Immunol. 18, 309-345 (2000).
-
(2000)
Annu. Rev. Immunol.
, vol.18
, pp. 309-345
-
-
Ashwell, J.D.1
Lu, F.W.2
Vacchio, M.S.3
-
70
-
-
37849048599
-
T helper 17 lineage differentiation is programmed by orphan nuclear receptors RORα and RORy
-
Yang, X. O. et al. T helper 17 lineage differentiation is programmed by orphan nuclear receptors RORα and RORy. Immunity 28, 29-39 (2008).
-
(2008)
Immunity
, vol.28
, pp. 29-39
-
-
Yang, X.O.1
-
71
-
-
64149103383
-
Pathophysiology of multiple sclerosis
-
Korn, T. Pathophysiology of multiple sclerosis. J. Neurol. 255, S2-S6 (2008).
-
(2008)
J. Neurol.
, vol.255
-
-
Korn, T.1
-
72
-
-
34447503805
-
H 17 and regulatory T cell differentiation mediated by retinoic acid
-
H 17 and regulatory T cell differentiation mediated by retinoic acid. Science 317, 256-260 (2007).
-
(2007)
Science
, vol.317
, pp. 256-260
-
-
Mucida, D.1
-
73
-
-
70350459594
-
The nuclear receptor PPARy selectively inhibits Th 17 differentiation in a T cell-intrinsic fashion and suppresses CNS autoimmunity
-
Klotz, L. et al. The nuclear receptor PPARy selectively inhibits Th 17 differentiation in a T cell-intrinsic fashion and suppresses CNS autoimmunity. J. Exp. Med. 206, 2079-2089 (2009).
-
(2009)
J. Exp. Med.
, vol.206
, pp. 2079-2089
-
-
Klotz, L.1
-
74
-
-
46149104979
-
Orphan nuclear receptor NR4A2 expressed in T cells from multiple sclerosis mediates production of inflammatory cytokines
-
Doi, Y. et al. Orphan nuclear receptor NR4A2 expressed in T cells from multiple sclerosis mediates production of inflammatory cytokines. Proc. Natl Acad. Sci. USA 105, 8381-8386 (2008).
-
(2008)
Proc. Natl Acad. Sci. USA
, vol.105
, pp. 8381-8386
-
-
Doi, Y.1
-
75
-
-
48749103031
-
The nuclear orphan receptor NR2F6 suppresses lymphocyte activation and T helper 17-dependent autoimmunity
-
Hermann-Kleiter, N. et al. The nuclear orphan receptor NR2F6 suppresses lymphocyte activation and T helper 17-dependent autoimmunity. Immunity 29, 205-216 (2008).
-
(2008)
Immunity
, vol.29
, pp. 205-216
-
-
Hermann-Kleiter, N.1
-
76
-
-
67650287382
-
Traditional concepts and future avenues of glucocorticoid action in experimental autoimmune encephalomyelitis and multiple sclerosis therapy
-
Luhder, F & Reichardt, H. M. Traditional concepts and future avenues of glucocorticoid action in experimental autoimmune encephalomyelitis and multiple sclerosis therapy. Crit. Rev. Immunol. 29, 255-273 (2009).
-
(2009)
Crit. Rev. Immunol.
, vol.29
, pp. 255-273
-
-
Luhder, F.1
Reichardt, H.M.2
-
77
-
-
50949102041
-
Peripheral T cells are the therapeutic targets of glucocorticoids in experimental autoimmune encephalomyelitis
-
Wust, S. et al. Peripheral T cells are the therapeutic targets of glucocorticoids in experimental autoimmune encephalomyelitis. J. Immunol. 180, 8434-8443 (2008).
-
(2008)
J. Immunol.
, vol.180
, pp. 8434-8443
-
-
Wust, S.1
-
78
-
-
68949145931
-
Apoptotic cells promote their own clearance and immune tolerance through activation of the nuclear receptor LXR
-
A-Gonzalez, N. et al. Apoptotic cells promote their own clearance and immune tolerance through activation of the nuclear receptor LXR. Immunity 31, 245-258 (2009).
-
(2009)
Immunity
, vol.31
, pp. 245-258
-
-
A-Gonzalez, N.1
-
79
-
-
70449094641
-
PPAR- senses and orchestrates clearance of apoptotic cells to promote tolerance
-
Mukundan, L. et al. PPAR- senses and orchestrates clearance of apoptotic cells to promote tolerance. Nature Med. 15, 1266-1272 (2009).
-
(2009)
Nature Med.
, vol.15
, pp. 1266-1272
-
-
Mukundan, L.1
-
80
-
-
34250351211
-
PPARy-dependent regulation of human macrophages in phagocytosis of apoptotic cells
-
Majai, G., Sarang, Z., Csomos, K., Zahuczky, G. & Fesus, L. PPARy-dependent regulation of human macrophages in phagocytosis of apoptotic cells. Eur. J. Immunol. 37, 1343-1354 (2007).
-
(2007)
Eur. J. Immunol.
, vol.37
, pp. 1343-1354
-
-
Majai, G.1
Sarang, Z.2
Csomos, K.3
Zahuczky, G.4
Fesus, L.5
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