-
1
-
-
79251501315
-
Fibroblast growth factors: from molecular evolution to roles in development, metabolism and disease
-
doi:10.1093/jb/mvq121
-
Itoh N, Ornitz DM. Fibroblast growth factors: from molecular evolution to roles in development, metabolism and disease. J Biochem (2011) 149:121-30. doi:10.1093/jb/mvq121
-
(2011)
J Biochem
, vol.149
, pp. 121-130
-
-
Itoh, N.1
Ornitz, D.M.2
-
2
-
-
84901496215
-
Fibroblast growth factor 21, the endocrine FGF pathway and novel treatments for metabolic syndrome
-
doi:10.1016/j.drudis.2013.10.021
-
Zhang J, Li Y. Fibroblast growth factor 21, the endocrine FGF pathway and novel treatments for metabolic syndrome. Drug Discov Today (2014) 19(5):579-89. doi:10.1016/j.drudis.2013.10.021
-
(2014)
Drug Discov Today
, vol.19
, Issue.5
, pp. 579-589
-
-
Zhang, J.1
Li, Y.2
-
3
-
-
84897109882
-
Inventing new medicines: the FGF21 story
-
doi:10.1016/j.molmet.2013.12.003
-
Kharitonenkov A, Adams AC. Inventing new medicines: the FGF21 story. Mol Metab (2014) 3:221-9. doi:10.1016/j.molmet.2013.12.003
-
(2014)
Mol Metab
, vol.3
, pp. 221-229
-
-
Kharitonenkov, A.1
Adams, A.C.2
-
4
-
-
84905679771
-
The breadth of FGF21's metabolic actions are governed by FGFR1 in adipose tissue
-
doi:10.1016/j.molmet.2012.08.007
-
Adams AC, Yang C, Coskun T, Cheng CC, Gimeno RE, Luo Y, et al. The breadth of FGF21's metabolic actions are governed by FGFR1 in adipose tissue. Mol Metab (2012) 2:31-7. doi:10.1016/j.molmet.2012.08.007
-
(2012)
Mol Metab
, vol.2
, pp. 31-37
-
-
Adams, A.C.1
Yang, C.2
Coskun, T.3
Cheng, C.C.4
Gimeno, R.E.5
Luo, Y.6
-
5
-
-
80052033268
-
FGF21 as an endocrine regulator in lipid metabolism: from molecular evolution to physiology and pathophysiology
-
doi:10.1155/2011/981315
-
Murata Y, Konishi M, Itoh N. FGF21 as an endocrine regulator in lipid metabolism: from molecular evolution to physiology and pathophysiology. J Nutr Metab (2011) 2011:981315. doi:10.1155/2011/981315
-
(2011)
J Nutr Metab
, vol.2011
, pp. 981315
-
-
Murata, Y.1
Konishi, M.2
Itoh, N.3
-
6
-
-
70349324370
-
Fibroblast growth factor 21 regulates lipolysis in white adipose tissue but is not required for ketogenesis and triglyceride clearance in liver
-
doi:10.1210/en.2009-0119
-
Hotta Y, Nakamura H, Konishi M, Murata Y, Takagi H, Matsumura S, et al. Fibroblast growth factor 21 regulates lipolysis in white adipose tissue but is not required for ketogenesis and triglyceride clearance in liver. Endocrinology (2009) 150:4625-33. doi:10.1210/en.2009-0119
-
(2009)
Endocrinology
, vol.150
, pp. 4625-4633
-
-
Hotta, Y.1
Nakamura, H.2
Konishi, M.3
Murata, Y.4
Takagi, H.5
Matsumura, S.6
-
7
-
-
84879931952
-
Fgf21 impairs adipocyte insulin sensitivity in mice fed a low-carbohydrate, high-fat ketogenic diet
-
doi:10.1371/journal.pone.0069330
-
Murata Y, Nishio K, Mochiyama T, Konishi M, Shimada M, Ohta H, et al. Fgf21 impairs adipocyte insulin sensitivity in mice fed a low-carbohydrate, high-fat ketogenic diet. PLoS One (2013) 8:e69330. doi:10.1371/journal.pone.0069330
-
(2013)
PLoS One
, vol.8
-
-
Murata, Y.1
Nishio, K.2
Mochiyama, T.3
Konishi, M.4
Shimada, M.5
Ohta, H.6
-
8
-
-
84883778996
-
FGF21 regulates metabolism and circadian behavior by acting on the nervous system
-
doi:10.1038/nm.3249
-
Bookout AL, de Groot MH, Owen BM, Lee S, Gautron L, Lawrence HL, et al. FGF21 regulates metabolism and circadian behavior by acting on the nervous system. Nat Med (2013) 19:1147-52. doi:10.1038/nm.3249
-
(2013)
Nat Med
, vol.19
, pp. 1147-1152
-
-
Bookout, A.L.1
de Groot, M.H.2
Owen, B.M.3
Lee, S.4
Gautron, L.5
Lawrence, H.L.6
-
9
-
-
84899893219
-
Fibroblast growth factor (Fgf) 21 is a novel target gene of the aryl hydrocarbon receptor (AhR)
-
doi:10.1016/j.taap.2014.04.013
-
Cheng X, Vispute SG, Liu J, Cheng C, Kharitonenkov A, Klaassen CD. Fibroblast growth factor (Fgf) 21 is a novel target gene of the aryl hydrocarbon receptor (AhR). Toxicol Appl Pharmacol (2014) 278:65-71. doi:10.1016/j.taap.2014.04.013
-
(2014)
Toxicol Appl Pharmacol
, vol.278
, pp. 65-71
-
-
Cheng, X.1
Vispute, S.G.2
Liu, J.3
Cheng, C.4
Kharitonenkov, A.5
Klaassen, C.D.6
-
10
-
-
84863012022
-
FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis
-
doi:10.1101/gad.177857.111
-
Fisher FM, Kleiner S, Douris N, Fox EC, Mepani RJ, Verdeguer F, et al. FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis. Genes Dev (2012) 26:271-81. doi:10.1101/gad.177857.111
-
(2012)
Genes Dev
, vol.26
, pp. 271-281
-
-
Fisher, F.M.1
Kleiner, S.2
Douris, N.3
Fox, E.C.4
Mepani, R.J.5
Verdeguer, F.6
-
11
-
-
84877260638
-
Adiponectin mediates the metabolic effects of FGF21 on glucose homeostasis and insulin sensitivity in mice
-
doi:10.1016/j.cmet.2013.04.005
-
Lin Z, Tian H, Lam KS, Lin S, Hoo RC, Konishi M, et al. Adiponectin mediates the metabolic effects of FGF21 on glucose homeostasis and insulin sensitivity in mice. Cell Metab (2013) 17:779-89. doi:10.1016/j.cmet.2013.04.005
-
(2013)
Cell Metab
, vol.17
, pp. 779-789
-
-
Lin, Z.1
Tian, H.2
Lam, K.S.3
Lin, S.4
Hoo, R.C.5
Konishi, M.6
-
12
-
-
84877272187
-
An FGF21-adiponectin-ceramide axis controls energy expenditure and insulin action in mice
-
doi:10.1016/j.cmet.2013.03.019
-
Holland WL, Adams AC, Brozinick JT, Bui HH, Miyauchi Y, Kusminski CM, et al. An FGF21-adiponectin-ceramide axis controls energy expenditure and insulin action in mice. Cell Metab (2013) 17:790-7. doi:10.1016/j.cmet.2013.03.019
-
(2013)
Cell Metab
, vol.17
, pp. 790-797
-
-
Holland, W.L.1
Adams, A.C.2
Brozinick, J.T.3
Bui, H.H.4
Miyauchi, Y.5
Kusminski, C.M.6
-
13
-
-
79960726293
-
Integrated regulation of hepatic metabolism by fibroblast growth factor 21 (FGF21) in vivo
-
doi:10.1210/en.2011-0281
-
Fisher FM, Estall JL, Adams AC, Antonellis PJ, Bina HA, Flier JS, et al. Integrated regulation of hepatic metabolism by fibroblast growth factor 21 (FGF21) in vivo. Endocrinology (2011) 152:2996-3004. doi:10.1210/en.2011-0281
-
(2011)
Endocrinology
, vol.152
, pp. 2996-3004
-
-
Fisher, F.M.1
Estall, J.L.2
Adams, A.C.3
Antonellis, P.J.4
Bina, H.A.5
Flier, J.S.6
-
14
-
-
79953886306
-
Thermogenic activation induces FGF21 expression and release in brown adipose tissue
-
doi:10.1074/jbc.M110.215889
-
Hondares E, Iglesias R, Giralt A, Gonzalez FJ, Giralt M, Mampel T, et al. Thermogenic activation induces FGF21 expression and release in brown adipose tissue. J Biol Chem (2011) 286:12983-90. doi:10.1074/jbc.M110.215889
-
(2011)
J Biol Chem
, vol.286
, pp. 12983-12990
-
-
Hondares, E.1
Iglesias, R.2
Giralt, A.3
Gonzalez, F.J.4
Giralt, M.5
Mampel, T.6
-
15
-
-
84872057896
-
Autophagy deficiency leads to protection from obesity and insulin resistance by inducing Fgf21 as a mitokine
-
doi:10.1038/nm.3014
-
Kim KH, Jeong YT, Oh H, Kim SH, Cho JM, Kim YN, et al. Autophagy deficiency leads to protection from obesity and insulin resistance by inducing Fgf21 as a mitokine. Nat Med (2013) 19:83-92. doi:10.1038/nm.3014
-
(2013)
Nat Med
, vol.19
, pp. 83-92
-
-
Kim, K.H.1
Jeong, Y.T.2
Oh, H.3
Kim, S.H.4
Cho, J.M.5
Kim, Y.N.6
-
16
-
-
84899516860
-
Skeletal muscle mitochondrial uncoupling drives endocrine cross-talk through induction of FGF21 as a myokine
-
doi:10.1152/ajpendo.00330.2013
-
Keipert S, Ost M, Johann K, Imber F, Jastroch M, Van Schothorst EM. Skeletal muscle mitochondrial uncoupling drives endocrine cross-talk through induction of FGF21 as a myokine. Am J Physiol Endocrinol Metab (2014) 306:E469-82. doi:10.1152/ajpendo.00330.2013
-
(2014)
Am J Physiol Endocrinol Metab
, vol.306
-
-
Keipert, S.1
Ost, M.2
Johann, K.3
Imber, F.4
Jastroch, M.5
Van Schothorst, E.M.6
-
17
-
-
84875327535
-
Expression of fibroblast growth factor-21 in muscle is associated with lipodystrophy, insulin resistance and lipid disturbances in patients with HIV
-
doi:10.1371/journal.pone.0055632
-
Lindegaard B, Hvid T, Grøndahl T, Frosig C, Gerstoft J, Hojman P, et al. Expression of fibroblast growth factor-21 in muscle is associated with lipodystrophy, insulin resistance and lipid disturbances in patients with HIV. PLoS One (2013) 8:e55632. doi:10.1371/journal.pone.0055632
-
(2013)
PLoS One
, vol.8
-
-
Lindegaard, B.1
Hvid, T.2
Grøndahl, T.3
Frosig, C.4
Gerstoft, J.5
Hojman, P.6
-
18
-
-
84879666287
-
Fibroblast growth factor 21 protects against cardiac hypertrophy in mice
-
doi:10.1038/ncomms3019
-
Planavila A, Redondo I, Hondares E, Vinciguerra M, Munts C, Iglesias R, et al. Fibroblast growth factor 21 protects against cardiac hypertrophy in mice. Nat Commun (2013) 4:2019. doi:10.1038/ncomms3019
-
(2013)
Nat Commun
, vol.4
, pp. 2019
-
-
Planavila, A.1
Redondo, I.2
Hondares, E.3
Vinciguerra, M.4
Munts, C.5
Iglesias, R.6
-
19
-
-
84892162004
-
Stressed liver and muscle call on adipocytes with FGF21
-
doi:10.3389/fendo.2013.00194
-
Luo Y, McKeehan WL. Stressed liver and muscle call on adipocytes with FGF21. Front Endocrinol (Lausanne) (2013) 4:194. doi:10.3389/fendo.2013.00194
-
(2013)
Front Endocrinol (Lausanne)
, vol.4
, pp. 194
-
-
Luo, Y.1
McKeehan, W.L.2
-
20
-
-
77952623888
-
The emergence of cold-induced brown adipocytes in mouse white fat depots is determined predominantly by white to brown adipocyte transdifferentiation
-
doi:10.1152/ajpendo.00600.2009
-
Barbatelli G, Murano I, Madsen L, Hao Q, Jimenez M, Kristiansen K, et al. The emergence of cold-induced brown adipocytes in mouse white fat depots is determined predominantly by white to brown adipocyte transdifferentiation. Am J Physiol Endocrinol Metab (2010) 298:E1244-53. doi:10.1152/ajpendo.00600.2009
-
(2010)
Am J Physiol Endocrinol Metab
, vol.298
-
-
Barbatelli, G.1
Murano, I.2
Madsen, L.3
Hao, Q.4
Jimenez, M.5
Kristiansen, K.6
-
21
-
-
84893452569
-
Irisin and FGF21 are cold-induced endocrine activators of brown fat function in humans
-
doi:10.1016/j.cmet.2013.12.017
-
Lee P, Linderman JD, Smith S, Brychta RJ, Wang J, Idelson C, et al. Irisin and FGF21 are cold-induced endocrine activators of brown fat function in humans. Cell Metab (2014) 19:302-9. doi:10.1016/j.cmet.2013.12.017
-
(2014)
Cell Metab
, vol.19
, pp. 302-309
-
-
Lee, P.1
Linderman, J.D.2
Smith, S.3
Brychta, R.J.4
Wang, J.5
Idelson, C.6
-
22
-
-
84872070199
-
Mild cold exposure modulates fibroblast growth factor 21 (FGF21) diurnal rhythm in humans: relationship between FGF21 levels, lipolysis, and cold-induced thermogenesis
-
doi:10.1210/jc.2012-3107
-
Lee P, Brychta RJ, Linderman J, Smith S, Chen KY, Celi FS. Mild cold exposure modulates fibroblast growth factor 21 (FGF21) diurnal rhythm in humans: relationship between FGF21 levels, lipolysis, and cold-induced thermogenesis. J Clin Endocrinol Metab (2013) 98:E98-102. doi:10.1210/jc.2012-3107
-
(2013)
J Clin Endocrinol Metab
, vol.98
-
-
Lee, P.1
Brychta, R.J.2
Linderman, J.3
Smith, S.4
Chen, K.Y.5
Celi, F.S.6
-
23
-
-
84863637593
-
FGF21 promotes metabolic homeostasis via white adipose and leptin in mice
-
doi:10.1371/journal.pone.0040164
-
Véniant MM, Hale C, Helmering J, Chen MM, Stanislaus S, Busby J, et al. FGF21 promotes metabolic homeostasis via white adipose and leptin in mice. PLoS One (2012) 7:e40164. doi:10.1371/journal.pone.0040164
-
(2012)
PLoS One
, vol.7
-
-
Véniant, M.M.1
Hale, C.2
Helmering, J.3
Chen, M.M.4
Stanislaus, S.5
Busby, J.6
-
24
-
-
54849438574
-
FGF21 is an Akt-regulated myokine
-
doi:10.1016/j.febslet.2008.10.021
-
Izumiya Y, Bina HA, Ouchi N, Akasaki Y, Kharitonenkov A, Walsh K. FGF21 is an Akt-regulated myokine. FEBS Lett (2008) 582:3805-10. doi:10.1016/j.febslet.2008.10.021
-
(2008)
FEBS Lett
, vol.582
, pp. 3805-3810
-
-
Izumiya, Y.1
Bina, H.A.2
Ouchi, N.3
Akasaki, Y.4
Kharitonenkov, A.5
Walsh, K.6
-
25
-
-
84875914619
-
Novel locus including FGF21 is associated with dietary macronutrient intake
-
doi:10.1093/hmg/ddt032
-
Chu AY, Workalemahu T, Paynter NP, Rose LM, Giulianini F, Tanaka T, et al. Novel locus including FGF21 is associated with dietary macronutrient intake. Hum Mol Genet (2013) 22:1895-902. doi:10.1093/hmg/ddt032
-
(2013)
Hum Mol Genet
, vol.22
, pp. 1895-1902
-
-
Chu, A.Y.1
Workalemahu, T.2
Paynter, N.P.3
Rose, L.M.4
Giulianini, F.5
Tanaka, T.6
-
26
-
-
84859754680
-
Associations of fibroblast growth factor 21 gene 3' untranslated region single-nucleotide polymorphisms with metabolic syndrome, obesity, and diabetes in a Han Chinese population
-
doi:10.1089/dna.2011.1302
-
Zhang M, Zeng L, Wang YJ, An ZM, Ying BW. Associations of fibroblast growth factor 21 gene 3' untranslated region single-nucleotide polymorphisms with metabolic syndrome, obesity, and diabetes in a Han Chinese population. DNA Cell Biol (2012) 31:547-52. doi:10.1089/dna.2011.1302
-
(2012)
DNA Cell Biol
, vol.31
, pp. 547-552
-
-
Zhang, M.1
Zeng, L.2
Wang, Y.J.3
An, Z.M.4
Ying, B.W.5
-
27
-
-
78650850911
-
Serum levels of FGF-21 are increased in coronary heart disease patients and are independently associated with adverse lipid profile
-
doi:10.1371/journal.pone.0015534
-
Lin Z, Wu Z, Yin X, Liu Y, Yan X, Lin S, et al. Serum levels of FGF-21 are increased in coronary heart disease patients and are independently associated with adverse lipid profile. PLoS One (2010) 5:e15534. doi:10.1371/journal.pone.0015534
-
(2010)
PLoS One
, vol.5
-
-
Lin, Z.1
Wu, Z.2
Yin, X.3
Liu, Y.4
Yan, X.5
Lin, S.6
-
28
-
-
84885039863
-
Serum fibroblast growth factor-21 levels are associated with carotid atherosclerosis independent of established cardiovascular risk factors
-
doi:10.1161/ATVBAHA.113.301599
-
Chow WS, Xu A, Woo YC, Tso AW, Cheung SC, Fong CH, et al. Serum fibroblast growth factor-21 levels are associated with carotid atherosclerosis independent of established cardiovascular risk factors. Arterioscler Thromb Vasc Biol (2013) 33:2454-9. doi:10.1161/ATVBAHA.113.301599
-
(2013)
Arterioscler Thromb Vasc Biol
, vol.33
, pp. 2454-2459
-
-
Chow, W.S.1
Xu, A.2
Woo, Y.C.3
Tso, A.W.4
Cheung, S.C.5
Fong, C.H.6
-
29
-
-
63849189712
-
Serum concentrations and tissue expression of a novel endocrine regulator fibroblast growth factor-21 in patients with type 2 diabetes and obesity
-
doi:10.1111/j.1365-2265.2008.03502.x
-
Mraz M, Bartlova M, Lacinova Z, Michalsky D, Kasalicky M, Haluzikova D, et al. Serum concentrations and tissue expression of a novel endocrine regulator fibroblast growth factor-21 in patients with type 2 diabetes and obesity. Clin Endocrinol (2009) 71:369-75. doi:10.1111/j.1365-2265.2008.03502.x
-
(2009)
Clin Endocrinol
, vol.71
, pp. 369-375
-
-
Mraz, M.1
Bartlova, M.2
Lacinova, Z.3
Michalsky, D.4
Kasalicky, M.5
Haluzikova, D.6
-
30
-
-
84891909814
-
Fibroblast growth factor 21 is a sensitive biomarker of mitochondrial disease
-
doi:10.1212/01.wnl.0000436068.43384.ef
-
Davis RL, Liang C, Edema-Hildebrand F, Riley C, Needham M, Sue CM. Fibroblast growth factor 21 is a sensitive biomarker of mitochondrial disease. Neurology (2013) 81:1819-26. doi:10.1212/01.wnl.0000436068.43384.ef
-
(2013)
Neurology
, vol.81
, pp. 1819-1826
-
-
Davis, R.L.1
Liang, C.2
Edema-Hildebrand, F.3
Riley, C.4
Needham, M.5
Sue, C.M.6
-
31
-
-
77956281358
-
Plasma concentrations of fibroblast growth factors 21 and 19 in patients with Cushing's syndrome
-
Durovcová V, Marek J, Hána V, Matoulek M, Zikán V, Haluzíková D, et al. Plasma concentrations of fibroblast growth factors 21 and 19 in patients with Cushing's syndrome. Physiol Res (2010) 59:415-22.
-
(2010)
Physiol Res
, vol.59
, pp. 415-422
-
-
Durovcová, V.1
Marek, J.2
Hána, V.3
Matoulek, M.4
Zikán, V.5
Haluzíková, D.6
-
32
-
-
84876812580
-
Serum levels of the adipokine fibroblast growth factor-21 are increased in preeclampsia
-
doi:10.1016/j.cyto.2013.02.019
-
Stepan H, Kley K, Hindricks J, Kralisch S, Jank A, Schaarschmidt W. Serum levels of the adipokine fibroblast growth factor-21 are increased in preeclampsia. Cytokine (2013) 62:322-6. doi:10.1016/j.cyto.2013.02.019
-
(2013)
Cytokine
, vol.62
, pp. 322-326
-
-
Stepan, H.1
Kley, K.2
Hindricks, J.3
Kralisch, S.4
Jank, A.5
Schaarschmidt, W.6
-
33
-
-
51649118899
-
Plasma concentrations of fibroblast growth factors 19 and 21 in patients with anorexia nervosa
-
doi:10.1210/jc.2008-0746
-
Dostálová I, Kaválková P, Haluzíková D, Lacinová Z, Mráz M, Papezová H, et al. Plasma concentrations of fibroblast growth factors 19 and 21 in patients with anorexia nervosa. J Clin Endocrinol Metab (2008) 3:3627-32. doi:10.1210/jc.2008-0746
-
(2008)
J Clin Endocrinol Metab
, vol.3
, pp. 3627-3632
-
-
Dostálová, I.1
Kaválková, P.2
Haluzíková, D.3
Lacinová, Z.4
Mráz, M.5
Papezová, H.6
|