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Volumn 16, Issue 2, 2015, Pages 2641-2662

Autophagy in DNA damage response

Author keywords

Apoptosis; Autophagy; Cancer therapy; DNA damage response; DNA repair; Senescence; Signal transduction

Indexed keywords

DNA TOPOISOMERASE (ATP HYDROLYSING); MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; MITOCHONDRIAL DNA; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; PROTEIN KINASE FER; PROTEIN P53; REACTIVE OXYGEN METABOLITE; TRANSCRIPTION FACTOR FKHRL1; ANTINEOPLASTIC AGENT; FORKHEAD TRANSCRIPTION FACTOR; SIGNAL TRANSDUCING ADAPTOR PROTEIN; SQSTM1 PROTEIN, HUMAN; TARGET OF RAPAMYCIN KINASE;

EID: 84921860060     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms16022641     Document Type: Review
Times cited : (125)

References (180)
  • 1
    • 78649336706 scopus 로고    scopus 로고
    • The DNA damage response: Making it safe to play with knives
    • Ciccia, A.; Elledge, S.J. The DNA damage response: Making it safe to play with knives. Mol. Cell 2010, 40, 179-204.
    • (2010) Mol. Cell , vol.40 , pp. 179-204
    • Ciccia, A.1    Elledge, S.J.2
  • 2
    • 77955267142 scopus 로고    scopus 로고
    • Chronic inflammation and mutagenesis
    • Ferguson, L.R. Chronic inflammation and mutagenesis. Mutat. Res. 2010, 690, 3-11.
    • (2010) Mutat. Res , vol.690 , pp. 3-11
    • Ferguson, L.R.1
  • 3
    • 70350504453 scopus 로고    scopus 로고
    • The DNA-damage response in human biology and disease
    • Jackson, S.P.; Bartek, J. The DNA-damage response in human biology and disease. Nature 2009, 467, 1071-1078.
    • (2009) Nature , vol.467 , pp. 1071-1078
    • Jackson, S.P.1    Bartek, J.2
  • 4
    • 84880797112 scopus 로고    scopus 로고
    • Autophagy and heterophagy dysregulation leads to retinal pigment epithelium dysfunction and development of age-related macular degeneration
    • Kaarniranta, K.; Sinha, D.; Blasiak, J.; Kauppinen, A.; Vereb, Z.; Salminen, A.; Boulton, M.E.; Petrovski, G. Autophagy and heterophagy dysregulation leads to retinal pigment epithelium dysfunction and development of age-related macular degeneration. Autophagy 2013, 9, 973-984.
    • (2013) Autophagy , vol.9 , pp. 973-984
    • Kaarniranta, K.1    Sinha, D.2    Blasiak, J.3    Kauppinen, A.4    Vereb, Z.5    Salminen, A.6    Boulton, M.E.7    Petrovski, G.8
  • 5
    • 78751575999 scopus 로고    scopus 로고
    • Application of molecular findings to the diagnosis and management of breast disease: Recent advances and challenges
    • Simpson, P.T.; Vargas, A.C.; Al-Ejeh, F.; Khanna, K.K.; Chenevix-Trench, G.; Lakhani, S.R. Application of molecular findings to the diagnosis and management of breast disease: Recent advances and challenges. Hum. Pathol. 2011, 42, 153-165.
    • (2011) Hum. Pathol , vol.42 , pp. 153-165
    • Simpson, P.T.1    Vargas, A.C.2    Al-Ejeh, F.3    Khanna, K.K.4    Chenevix-Trench, G.5    Lakhani, S.R.6
  • 8
    • 70349859881 scopus 로고    scopus 로고
    • DNA damage, aging, and cancer
    • Hoeijmakers, J.H. DNA damage, aging, and cancer. N. Engl. J. Med. 2009, 367, 1475-1485.
    • (2009) N. Engl. J. Med , vol.367 , pp. 1475-1485
    • Hoeijmakers, J.H.1
  • 9
    • 33646187811 scopus 로고    scopus 로고
    • The multifaceted mismatch-repair system
    • Jiricny, J. The multifaceted mismatch-repair system. Nat. Rev. Mol. Cell Biol. 2006, 7, 335-346.
    • (2006) Nat. Rev. Mol. Cell Biol , vol.7 , pp. 335-346
    • Jiricny, J.1
  • 10
    • 84865364870 scopus 로고    scopus 로고
    • Playing the end game: DNA double-strand break repair pathway choice
    • Chapman, J.R.; Taylor, M.R.; Boulton, S.J. Playing the end game: DNA double-strand break repair pathway choice. Mol. Cell 2012, 47, 497-510.
    • (2012) Mol. Cell , vol.47 , pp. 497-510
    • Chapman, J.R.1    Taylor, M.R.2    Boulton, S.J.3
  • 11
    • 0031032817 scopus 로고    scopus 로고
    • Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress
    • Yakes, F.M.; van Houten, B. Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress. Proc. Natl. Acad. Sci. USA 1997, 94, 514-519.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 514-519
    • Yakes, F.M.1    Van Houten, B.2
  • 12
    • 11844297408 scopus 로고    scopus 로고
    • Effects of variation in superoxide dismutases (SOD) on oxidative stress and apoptosis in lens epithelium
    • Reddy, V.N.; Kasahara, E.; Hiraoka, M.; Lin, L.R.; Ho, Y.S. Effects of variation in superoxide dismutases (SOD) on oxidative stress and apoptosis in lens epithelium. Exp. Eye Res. 2004, 79, 859-868.
    • (2004) Exp. Eye Res , vol.79 , pp. 859-868
    • Reddy, V.N.1    Kasahara, E.2    Hiraoka, M.3    Lin, L.R.4    Ho, Y.S.5
  • 13
    • 17644386166 scopus 로고    scopus 로고
    • Human mitochondrial peroxiredoxin 5 protects from mitochondrial DNA damages induced by hydrogen peroxide
    • Banmeyer, I.C.; Clippe, A.; Knoops, B. Human mitochondrial peroxiredoxin 5 protects from mitochondrial DNA damages induced by hydrogen peroxide. FEBSLett. 2005, 579, 2327-2333.
    • (2005) Febslett , vol.579 , pp. 2327-2333
    • Banmeyer, I.C.1    Clippe, A.2    Knoops, B.3
  • 16
    • 0035238101 scopus 로고    scopus 로고
    • Base excision repair of mitochondrial DNA damage in mammalian cells
    • Le Doux, S.P.; Wilson, G.L. Base excision repair of mitochondrial DNA damage in mammalian cells. Prog. Nucleic Acid Res. Mol. Biol. 2001, 68, 273-284.
    • (2001) Prog. Nucleic Acid Res. Mol. Biol , vol.68 , pp. 273-284
    • Le Doux, S.P.1    Wilson, G.L.2
  • 19
    • 77953523665 scopus 로고    scopus 로고
    • Discovery of a novel function for human Rad51: Maintenance of the mitochondrial genome
    • Sage, J.M.; Gildemeister, O.S.; Knight, K.L. Discovery of a novel function for human Rad51: Maintenance of the mitochondrial genome. J. Biol. Chem. 2010, 285, 18984-18990.
    • (2010) J. Biol. Chem , vol.285 , pp. 18984-18990
    • Sage, J.M.1    Gildemeister, O.S.2    Knight, K.L.3
  • 20
    • 0033557234 scopus 로고    scopus 로고
    • Double strand break rejoining by mammalian mitochondrial extracts
    • Lakshmipathy, U.; Campbell, C. Double strand break rejoining by mammalian mitochondrial extracts. Nucleic Acids Res. 1999, 27, 11198-11204.
    • (1999) Nucleic Acids Res , vol.27 , pp. 11198-11204
    • Lakshmipathy, U.1    Campbell, C.2
  • 23
    • 3943107573 scopus 로고    scopus 로고
    • Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints
    • Sancar, A.; Lindsey-Boltz, L.A.; Unsal-Kacmaz, K.; Linn, S. Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints. Annu. Rev. Biochem. 2004, 73, 39-85.
    • (2004) Annu. Rev. Biochem. , vol.73 , pp. 39-85
    • Sancar, A.1    Lindsey-Boltz, L.A.2    Unsal-Kacmaz, K.3    Linn, S.4
  • 24
    • 57949116437 scopus 로고    scopus 로고
    • DNA-PK: The means to justify the ends?
    • Meek, K.; Dang, V.; Lees-Miller, S.P. DNA-PK: The means to justify the ends? Adv. Immunol. 2008, 99, 33-58.
    • (2008) Adv. Immunol , vol.99 , pp. 33-58
    • Meek, K.1    Dang, V.2    Lees-Miller, S.P.3
  • 25
    • 36749022214 scopus 로고    scopus 로고
    • The DNA damage response: Ten years after
    • Harpe, J.W.; Elledge, S.J. The DNA damage response: Ten years after. Mol. Cell 2007, 28, 739-745.
    • (2007) Mol. Cell , vol.28 , pp. 739-745
    • Harpe, J.W.1    Elledge, S.J.2
  • 28
    • 47749141560 scopus 로고    scopus 로고
    • ATR: An essential regulator of genome integrity
    • Cimprich, K.A.; Cortez, D. ATR: An essential regulator of genome integrity. Nat. Rev. Mol. Cell Biol. 2008, 9, 616-627.
    • (2008) Nat. Rev. Mol. Cell Biol , vol.9 , pp. 616-627
    • Cimprich, K.A.1    Cortez, D.2
  • 29
    • 0031036995 scopus 로고    scopus 로고
    • RAD9, RAD17, and RAD24 are required for S phase regulation in Saccharomyces cerevisiae in response to DNA damage
    • Paulovich, A.G.; Margulies, R.U.; Garvik, B.M.; Hartwell, L.H. RAD9, RAD17, and RAD24 are required for S phase regulation in Saccharomyces cerevisiae in response to DNA damage. Genetics 1997, 745, 45-62.
    • (1997) Genetics , vol.745 , pp. 45-62
    • Paulovich, A.G.1    Margulies, R.U.2    Garvik, B.M.3    Hartwell, L.H.4
  • 30
    • 0033534613 scopus 로고    scopus 로고
    • Human homologs of Schizosaccharomyces pombe Rad1, Hus1, and Rad9 form a DNA damage-responsive protein complex
    • Volkmer, E.; Karnitz, L.M. Human homologs of Schizosaccharomyces pombe Rad1, Hus1, and Rad9 form a DNA damage-responsive protein complex. J. Biol. Chem. 1999, 274, 567-570.
    • (1999) J. Biol. Chem. , vol.274 , pp. 567-570
    • Volkmer, E.1    Karnitz, L.M.2
  • 31
    • 0033582906 scopus 로고    scopus 로고
    • A sliding clamp model for the Rad1 family of cell cycle checkpoint proteins
    • Thelen, M.P.; Venclovas, C.; Fidelis, K. A sliding clamp model for the Rad1 family of cell cycle checkpoint proteins. Cell 1999, 96, 769-770.
    • (1999) Cell , vol.96 , pp. 769-770
    • Thelen, M.P.1    Venclovas, C.2    Fidelis, K.3
  • 32
    • 0028844502 scopus 로고
    • Fission yeast rad17: A homologue of budding yeast RAD24 that shares regions of sequence similarity with DNA polymerase accessory proteins
    • Griffiths, D.J.; Barbet, N.C.; McCready, S.; Lehmann, A.R.; Carr, A.M. Fission yeast rad17: A homologue of budding yeast RAD24 that shares regions of sequence similarity with DNA polymerase accessory proteins. EMBO J. 1995, 74, 5812-5823.
    • (1995) EMBO J , vol.74 , pp. 5812-5823
    • Griffiths, D.J.1    Barbet, N.C.2    McCready, S.3    Lehmann, A.R.4    Carr, A.M.5
  • 33
    • 0033965418 scopus 로고    scopus 로고
    • A novel Rad24 checkpoint protein complex closely related to replication factor C
    • Green, C.M.; Erdjument-Bromage, H.; Tempst, P.; Lowndes, N.F. A novel Rad24 checkpoint protein complex closely related to replication factor C. Curr. Biol. 2000, 70, 39-42.
    • (2000) Curr. Biol , vol.70 , pp. 39-42
    • Green, C.M.1    Erdjument-Bromage, H.2    Tempst, P.3    Lowndes, N.F.4
  • 34
    • 0033858055 scopus 로고    scopus 로고
    • Rfc5, in cooperation with Rad24, controls DNA damage checkpoints throughout the cell cycle in Saccharomyces cerevisiae
    • Naiki, T.; Shimomura, T.; Kondo, T.; Matsumoto, K.; Sugimoto, K. Rfc5, in cooperation with Rad24, controls DNA damage checkpoints throughout the cell cycle in Saccharomyces cerevisiae. Mol. Cell. Biol. 2000, 20, 5888-5896.
    • (2000) Mol. Cell. Biol , vol.20 , pp. 5888-5896
    • Naiki, T.1    Shimomura, T.2    Kondo, T.3    Matsumoto, K.4    Sugimoto, K.5
  • 36
    • 84918769390 scopus 로고    scopus 로고
    • Poly-ADP-ribosylation signaling during DNA damage repair
    • Golia, B.; Singh, H.R.; Timinszki, G. Poly-ADP-ribosylation signaling during DNA damage repair. Front. Biosci. 2015, 20, 440-457.
    • (2015) Front. Biosci , vol.20 , pp. 440-457
    • Golia, B.1    Singh, H.R.2    Timinszki, G.3
  • 37
    • 0037472924 scopus 로고    scopus 로고
    • DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation
    • Bakkenist, C.J.; Kastan, M.B. DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. Nature 2003, 427, 499-506.
    • (2003) Nature , vol.427 , pp. 499-506
    • Bakkenist, C.J.1    Kastan, M.B.2
  • 38
    • 0034655991 scopus 로고    scopus 로고
    • BASC, a super complex "of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures
    • Wang, Y.; Cortez, D.; Yazdi, P.; Neff, N.; Elledge, S.J.; Qin, J. BASC, a super complex "of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures. Genes Dev. 2000, 74, 927-939.
    • (2000) Genes Dev , vol.74 , pp. 927-939
    • Wang, Y.1    Cortez, D.2    Yazdi, P.3    Neff, N.4    Elledge, S.J.5    Qin, J.6
  • 39
    • 0033615547 scopus 로고    scopus 로고
    • Sensing of ionizing radiation-induced DNA damage by ATM through interaction with histone deacetylase
    • Kim, G.D.; Choi, Y.H.; Dimtchev, A.; Jeong, S.J.; Dritschilo, A.; Jung, M. Sensing of ionizing radiation-induced DNA damage by ATM through interaction with histone deacetylase. J. Biol. Chem. 1999, 274, 31127-33130.
    • (1999) J. Biol. Chem , vol.274 , pp. 31127-33130
    • Kim, G.D.1    Choi, Y.H.2    Dimtchev, A.3    Jeong, S.J.4    Dritschilo, A.5    Jung, M.6
  • 40
    • 0033517797 scopus 로고    scopus 로고
    • Molecular association between ATR and two components of the nucleosome remodeling and deacetylating complex, HDAC2 and CHD4
    • Schmidt, D.R.; Schreiber, S.L. Molecular association between ATR and two components of the nucleosome remodeling and deacetylating complex, HDAC2 and CHD4. Biochemistry 1999, 38, 14711-14717.
    • (1999) Biochemistry , vol.38 , pp. 14711-14717
    • Schmidt, D.R.1    Schreiber, S.L.2
  • 42
    • 84885663744 scopus 로고    scopus 로고
    • Histone deacetylase regulation of ATM-mediated DNA damage signaling
    • Thurn, K.T.; Thomas, S.; Raha, P.; Qureshi, I.; Munster, P.N. Histone deacetylase regulation of ATM-mediated DNA damage signaling. Mol. Cancer Ther. 2013, 72, 2078-2087.
    • (2013) Mol. Cancer Ther , vol.72 , pp. 2078-2087
    • Thurn, K.T.1    Thomas, S.2    Raha, P.3    Qureshi, I.4    Munster, P.N.5
  • 44
    • 33749178260 scopus 로고    scopus 로고
    • Necrosis, a well-orchestrated form of cell demise: Signaling cascades, important mediators and concomitant immune response
    • Festjens, N.; VandenBerghe, T.; Vandenabeele, P. Necrosis, a well-orchestrated form of cell demise: Signaling cascades, important mediators and concomitant immune response. Biochim. Biophys. Acta 2006, 7757, 1371-1387.
    • (2006) Biochim. Biophys. Acta , vol.7757 , pp. 1371-1387
    • Festjens, N.1    Vandenberghe, T.2    Vandenabeele, P.3
  • 45
    • 84920288424 scopus 로고    scopus 로고
    • Lipid metabolism, apoptosis and cancer therapy
    • Huang, C.; Freter, C. Lipid metabolism, apoptosis and cancer therapy. Int. J. Mol. Sci. 2015, 76, 924-949.
    • (2015) Int. J. Mol. Sci , vol.76 , pp. 924-949
    • Huang, C.1    Freter, C.2
  • 46
    • 0029007855 scopus 로고
    • The TNF receptor 1-associated protein TRADD signals cell death and NFKB activation
    • Hsu, H.; Xiong, J.; Goeddel, D.V. The TNF receptor 1-associated protein TRADD signals cell death and NFKB activation. Cell 1995, 87, 495-504.
    • (1995) Cell , vol.87 , pp. 495-504
    • Hsu, H.1    Xiong, J.2    Goeddel, D.V.3
  • 47
    • 0037204952 scopus 로고    scopus 로고
    • The Fas signaling pathway: More than a paradigm
    • Wajant, H. The Fas signaling pathway: More than a paradigm. Science 2002, 29, 1635-1636.
    • (2002) Science , vol.29 , pp. 1635-1636
    • Wajant, H.1
  • 48
    • 0028883850 scopus 로고
    • Cytotoxicity dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor
    • Kischkel, F.C.; Hellbardt, S.; Behrmann, I.; Germer, M.; Pawlita, M.; Krammer, P.H.; Peter, M.E. Cytotoxicity dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor. EMBO J. 1995, 74, 5579-5588.
    • (1995) EMBO J , vol.74 , pp. 5579-5588
    • Kischkel, F.C.1    Hellbardt, S.2    Behrmann, I.3    Germer, M.4    Pawlita, M.5    Krammer, P.H.6    Peter, M.E.7
  • 50
    • 78549279860 scopus 로고    scopus 로고
    • Mitochondria in cell death
    • Parsons, M.J.; Green, D.R. Mitochondria in cell death. Essays Biochem. 2010, 47, 99-114.
    • (2010) Essays Biochem , vol.47 , pp. 99-114
    • Parsons, M.J.1    Green, D.R.2
  • 51
    • 34250308322 scopus 로고    scopus 로고
    • Apoptosis: A review of programmed cell death
    • Elmore, S. Apoptosis: A review of programmed cell death. Toxicol. Pathol. 2007, 35, 495-516.
    • (2007) Toxicol. Pathol , vol.35 , pp. 495-516
    • Elmore, S.1
  • 52
    • 0035206383 scopus 로고    scopus 로고
    • Mechanisms of p53-dependent apoptosis
    • Schuler, M.; Green, D.R. Mechanisms of p53-dependent apoptosis. Biochem. Soc. Trans. 2001, 29, 684-688.
    • (2001) Biochem. Soc. Trans , vol.29 , pp. 684-688
    • Schuler, M.1    Green, D.R.2
  • 53
    • 33747884339 scopus 로고    scopus 로고
    • DNA damage-induced cell death by apoptosis
    • Roos, W.P.; Kaina, B. DNA damage-induced cell death by apoptosis. Trends Mol. Med. 2006, 72, 440-450.
    • (2006) Trends Mol. Med , vol.72 , pp. 440-450
    • Roos, W.P.1    Kaina, B.2
  • 54
    • 33646756222 scopus 로고    scopus 로고
    • Dissecting p53-dependent apoptosis
    • Chipuk, J.E.; Green, D.R. Dissecting p53-dependent apoptosis. Cell Death Differ. 2006, 73, 994-1002.
    • (2006) Cell Death Differ , vol.73 , pp. 994-1002
    • Chipuk, J.E.1    Green, D.R.2
  • 56
    • 1842583789 scopus 로고    scopus 로고
    • Development by self-digestion: Molecular mechanisms and biological functions of autophagy
    • Levine, B.; Klionsky, D.J. Development by self-digestion: Molecular mechanisms and biological functions of autophagy. Cell 2004, 6, 463-477.
    • (2004) Cell , vol.6 , pp. 463-477
    • Levine, B.1    Klionsky, D.J.2
  • 57
    • 4544385218 scopus 로고    scopus 로고
    • Autophagy: Many paths to the same end
    • Cuervo, A.M. Autophagy: Many paths to the same end. Mol. Cell. Biochem. 2004, 263, 55-72.
    • (2004) Mol. Cell. Biochem , vol.263 , pp. 55-72
    • Cuervo, A.M.1
  • 58
    • 0019506466 scopus 로고
    • Autophagy, heterophagy, microautophagy and crinophagy as the means for intracellular degradation
    • Marzella, L.; Ahlberg, J.; Glaumann, H. Autophagy, heterophagy, microautophagy and crinophagy as the means for intracellular degradation. Virchows Arch. B 1981, 36, 219-234.
    • (1981) Virchows Arch. B , vol.36 , pp. 219-234
    • Marzella, L.1    Ahlberg, J.2    Glaumann, H.3
  • 59
    • 0029948779 scopus 로고    scopus 로고
    • Induction of apoptosis by the tumor suppressor protein BRCA1
    • Shao, N.; Chai, Y.L.; Shyam, E.; Reddy, P.; Rao, V.N. Induction of apoptosis by the tumor suppressor protein BRCA1. Oncogene 1996, 73, 1-7.
    • (1996) Oncogene , vol.73 , pp. 1-7
    • Shao, N.1    Chai, Y.L.2    Shyam, E.3    Reddy, P.4    Rao, V.N.5
  • 60
    • 28244474928 scopus 로고    scopus 로고
    • BRCA1 phosphorylation regulates caspase-3 activation in UV-induced apoptosis
    • Martin, S.A.; Ouchi, T. BRCA1 phosphorylation regulates caspase-3 activation in UV-induced apoptosis. Cancer Res. 2005, 65, 10657-10662.
    • (2005) Cancer Res , vol.65 , pp. 10657-10662
    • Martin, S.A.1    Ouchi, T.2
  • 61
    • 3242886503 scopus 로고    scopus 로고
    • Role of DNA-PK in the cellular response to DNA double-strand breaks
    • Burma, S.; Chen, D.J. Role of DNA-PK in the cellular response to DNA double-strand breaks. DNA Repair 2004, 3, 909-918.
    • (2004) DNA Repair , vol.3 , pp. 909-918
    • Burma, S.1    Chen, D.J.2
  • 62
    • 0037112834 scopus 로고    scopus 로고
    • Functional interaction between DNA-PKcs and telomerase in telomere length maintenance
    • Espejel, S.; Franco, S.; Sgura, A.; Gae, D.; Bailey, S.M.; Taccioli, G.E.; Blasco, M.A. Functional interaction between DNA-PKcs and telomerase in telomere length maintenance. EMBO J. 2002, 27, 6275-6287.
    • (2002) EMBO J , vol.27 , pp. 6275-6287
    • Espejel, S.1    Franco, S.2    Sgura, A.3    Gae, D.4    Bailey, S.M.5    Taccioli, G.E.6    Blasco, M.A.7
  • 63
    • 2942547771 scopus 로고    scopus 로고
    • Shorter telomeres, accelerated ageing and increased lymphoma in DNA-PKcs deficient mice
    • Espejel, S.; Martin, M.; Klatt, P.; Martin-Caballero, J.; Flores, J.M.; Blasco, M.A. Shorter telomeres, accelerated ageing and increased lymphoma in DNA-PKcs deficient mice. EMBO Rep. 2004, 5, 503-509.
    • (2004) EMBO Rep , vol.5 , pp. 503-509
    • Espejel, S.1    Martin, M.2    Klatt, P.3    Martin-Caballero, J.4    Flores, J.M.5    Blasco, M.A.6
  • 64
    • 84857891632 scopus 로고    scopus 로고
    • On PAR with PARP: Cellular stress signaling through poly (ADP-ribose) and PARP-1
    • Luo, X.; Kraus, W.L. On PAR with PARP: Cellular stress signaling through poly (ADP-ribose) and PARP-1. Genes Dev. 2012, 26, 417-432.
    • (2012) Genes Dev , vol.26 , pp. 417-432
    • Luo, X.1    Kraus, W.L.2
  • 66
    • 84878644301 scopus 로고    scopus 로고
    • Treatment of triple-negative breast cancer using anti-EGFR-directed radioimmunotherapy combined with radiosensitizing chemotherapy and PARP inhibitor
    • Al-Ejeh, F.; Shi, W.; Miranda, M.; Simpson, P.T.; Vargas, A.C.; Song, S.; Wiegmans, A.P.; Swarbrick, A.; Welm, A.L.; Brown, M.P. et al. Treatment of triple-negative breast cancer using anti-EGFR-directed radioimmunotherapy combined with radiosensitizing chemotherapy and PARP inhibitor. J. Nucl. Med. 2013, 54, 913-921.
    • (2013) J. Nucl. Med , vol.54 , pp. 913-921
    • Al-Ejeh, F.1    Shi, W.2    Miranda, M.3    Simpson, P.T.4    Vargas, A.C.5    Song, S.6    Wiegmans, A.P.7    Swarbrick, A.8    Welm, A.L.9    Brown, M.P.10
  • 68
    • 2442621492 scopus 로고    scopus 로고
    • Role of AIF in caspase-dependent and caspase-independent cell death
    • Cregan, S.P.; Dawson, V.L.; Slack, R.S. Role of AIF in caspase-dependent and caspase-independent cell death. Oncogene 2004, 23, 2785-2796.
    • (2004) Oncogene , vol.23 , pp. 2785-2796
    • Cregan, S.P.1    Dawson, V.L.2    Slack, R.S.3
  • 69
    • 78650215702 scopus 로고    scopus 로고
    • Harnessing the complexity of DNA-damage response pathways to improve cancer treatment outcomes
    • Al-Ejeh, F.; Kumar, R.; Wiegmans, A.; Lakhani, S.R.; Brown, M.P.; Khanna, K.K. Harnessing the complexity of DNA-damage response pathways to improve cancer treatment outcomes. Oncogene 2010, 29, 6085-6098.
    • (2010) Oncogene , vol.29 , pp. 6085-6098
    • Al-Ejeh, F.1    Kumar, R.2    Wiegmans, A.3    Lakhani, S.R.4    Brown, M.P.5    Khanna, K.K.6
  • 70
    • 0023858711 scopus 로고
    • Regulation of microautophagy and basal protein turnover in rat liver. Effects of short-term starvation
    • Mortimore, G.E.; Lardeux, B.R.; Adams, C.E. Regulation of microautophagy and basal protein turnover in rat liver. Effects of short-term starvation. J. Biol. Chem. 1988, 263, 2506-2512.
    • (1988) J. Biol. Chem. , vol.263 , pp. 2506-2512
    • Mortimore, G.E.1    Lardeux, B.R.2    Adams, C.E.3
  • 71
    • 0034914206 scopus 로고    scopus 로고
    • Molecular chaperone complex at the lysosomal membrane is required for protein translocation
    • Agarraberes, F.; Dice, J.F. A molecular chaperone complex at the lysosomal membrane is required for protein translocation. J. Cell Sci. 2001, 774, 2491-2499.
    • (2001) J. Cell Sci , vol.774 , pp. 2491-2499
    • Agarraberes, F.1    Dice, J.2
  • 72
    • 4344673498 scopus 로고    scopus 로고
    • Mechanisms of chaperone-mediated autophagy
    • Majeski, A.E.; Dice, J.F. Mechanisms of chaperone-mediated autophagy. Int. J. Biochem. Cell Biol. 2004, 36, 2435-2444.
    • (2004) Int. J. Biochem. Cell Biol , vol.36 , pp. 2435-2444
    • Majeski, A.E.1    Dice, J.F.2
  • 73
    • 33745023775 scopus 로고    scopus 로고
    • Chaperone-mediated autophagy in aging and disease
    • Massey, A.C.; Zhang, C.; Cuervo, A.M. Chaperone-mediated autophagy in aging and disease. Curr. Top. Dev. Biol. 2006, 73, 205-235.
    • (2006) Curr. Top. Dev. Biol. , vol.73 , pp. 205-235
    • Massey, A.C.1    Zhang, C.2    Cuervo, A.M.3
  • 74
    • 0034537290 scopus 로고    scopus 로고
    • Autophagy as a regulated pathway of cellular degradation
    • Klionsky, D.J.; Emr, S.D. Autophagy as a regulated pathway of cellular degradation. Science 2000, 290, 1717-1721.
    • (2000) Science , vol.290 , pp. 1717-1721
    • Klionsky, D.J.1    Emr, S.D.2
  • 75
    • 20344387475 scopus 로고    scopus 로고
    • Autophagy: Dual roles in life and death?
    • Baehrecke, E.H. Autophagy: Dual roles in life and death? Nat. Rev. Mol. Cell Biol 2005, 6, 505-510.
    • (2005) Nat. Rev. Mol. Cell Biol , vol.6 , pp. 505-510
    • Baehrecke, E.H.1
  • 77
    • 84922489435 scopus 로고    scopus 로고
    • Oxidative stress and autophagy: The clash between damage and metabolic needs
    • Filomeni, G.; de Zio, D.; Cecconi, F. Oxidative stress and autophagy: the clash between damage and metabolic needs. Cell Death Differ. 2014, doi:10.1038/ccd.2014150.
    • (2014) Cell Death Differ
    • Filomeni, G.1    De Zio, D.2    Cecconi, F.3
  • 78
    • 78649338141 scopus 로고    scopus 로고
    • Autophagy and the integrated stress response.Mol
    • Kroemer, G.; Marino, G.; Levine, B. Autophagy and the integrated stress response.Mol. Cell2010, 40, 280-293.
    • Cell2010 , vol.40 , pp. 280-293
    • Kroemer, G.1    Marino, G.2    Levine, B.3
  • 80
    • 84901782394 scopus 로고    scopus 로고
    • P62/SQSTM1 synergizes with autophagy for tumor growth in vivo
    • Wei, H.; Wang, C.; Croce, C.M.; Guan, J.L. p62/SQSTM1 synergizes with autophagy for tumor growth in vivo. Genes Dev. 2014, 28, 1204-1216.
    • (2014) Genes Dev , vol.28 , pp. 1204-1216
    • Wei, H.1    Wang, C.2    Croce, C.M.3    Guan, J.L.4
  • 82
    • 77951221542 scopus 로고    scopus 로고
    • The role of the Atg1/ULK1 complex in autophagy regulation
    • Mizushima, N. The role of the Atg1/ULK1 complex in autophagy regulation. Curr. Opin. Cell Biol. 2010, 22, 132-139.
    • (2010) Curr. Opin. Cell Biol , vol.22 , pp. 132-139
    • Mizushima, N.1
  • 83
    • 84856438107 scopus 로고    scopus 로고
    • Pro-tumorigenic function of autophagy in mammalian oncogenesis
    • Wei, H.; Guan, J.L. Pro-tumorigenic function of autophagy in mammalian oncogenesis. Autophagy 2012, 8, 129-131.
    • (2012) Autophagy , vol.8 , pp. 129-131
    • Wei, H.1    Guan, J.L.2
  • 84
    • 84912528393 scopus 로고    scopus 로고
    • MTOR and autophagy: A dynamic relationship governed by nutrients and energy
    • Dunlop, E.A., Tee, A.R. mTOR and autophagy: A dynamic relationship governed by nutrients and energy. Semin. Cell Dev. Biol. 2014, 36, 121-129.
    • (2014) Semin. Cell Dev. Biol , vol.36 , pp. 121-129
    • Dunlop, E.A.1    Tee, A.R.2
  • 85
    • 84921887492 scopus 로고    scopus 로고
    • Hexokinase II integrates energy metabolism and cellular protection: Akting on mitochondria and TORcing to autophagy
    • Roberts, D.J.; Miyamoto, S. Hexokinase II integrates energy metabolism and cellular protection: Akting on mitochondria and TORcing to autophagy. Cell Death Differ. 2015, 22, 248-257.
    • (2015) Cell Death Differ , vol.22 , pp. 248-257
    • Roberts, D.J.1    Miyamoto, S.2
  • 86
    • 0033565655 scopus 로고    scopus 로고
    • Apg16p is required for the function of the Apg12p-Apg5p conjugate in the yeast autophagy pathway
    • Mizushima, N.; Noda, T.; Ohsumi, Y. Apg16p is required for the function of the Apg12p-Apg5p conjugate in the yeast autophagy pathway. EMBO J. 1999, 78, 3888-3896.
    • (1999) EMBO J , vol.78 , pp. 3888-3896
    • Mizushima, N.1    Noda, T.2    Ohsumi, Y.3
  • 87
    • 0037166241 scopus 로고    scopus 로고
    • Formation of the approximately 350 kDa Apg12-Apg5-Apg16 multimeric complex, mediated by Apg16 oligomerization, is essential for autophagy in yeast
    • Kuma, A.; Mizuchima, N.; Ishihara, N.; Ohsumi, Y. Formation of the approximately 350 kDa Apg12-Apg5-Apg16 multimeric complex, mediated by Apg16 oligomerization, is essential for autophagy in yeast. J. Biol. Chem. 2002, 277, 18619-18625.
    • (2002) J. Biol. Chem , vol.277 , pp. 18619-18625
    • Kuma, A.1    Mizuchima, N.2    Ishihara, N.3    Ohsumi, Y.4
  • 89
    • 59249089394 scopus 로고    scopus 로고
    • Beclin-1 forms two distinct phosphatidylinositol 3-kinase complexes with mammalian Atg14 and UVRAG
    • Itakura, E.; Kishi, C.; Inoue, K.; Mizushima, N. Beclin-1 forms two distinct phosphatidylinositol 3-kinase complexes with mammalian Atg14 and UVRAG. Mol. Biol. Cell 2008, 79, 5360-5372.
    • (2008) Mol. Biol. Cell , vol.79 , pp. 5360-5372
    • Itakura, E.1    Kishi, C.2    Inoue, K.3    Mizushima, N.4
  • 90
    • 33745751085 scopus 로고    scopus 로고
    • Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG
    • Liang, C.; Feng, P.; Ku, B.; Dotan, I.; Canaani, D.; Oh, B.H.; Jung, J.U. Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG. Nat. Cell Biol. 2006, 8, 688-699.
    • (2006) Nat. Cell Biol , vol.8 , pp. 688-699
    • Liang, C.1    Feng, P.2    Ku, B.3    Dotan, I.4    Canaani, D.5    Oh, B.H.6    Jung, J.U.7
  • 91
    • 58049192897 scopus 로고    scopus 로고
    • Identification of Barkor as a mammalian autophagy-specific factor for Beclin 1 and class III phosphatidylinositol 3-kinase
    • Sun, Q.; Fan, W.; Chen, K.; Ding, X.; Chen, S.; Zhong, Q. Identification of Barkor as a mammalian autophagy-specific factor for Beclin 1 and class III phosphatidylinositol 3-kinase. Proc. Natl. Acad. Sci. USA 2008, 705, 19211-19216.
    • (2008) Proc. Natl. Acad. Sci. USA , vol.705 , pp. 19211-19216
    • Sun, Q.1    Fan, W.2    Chen, K.3    Ding, X.4    Chen, S.5    Zhong, Q.6
  • 93
    • 0035809160 scopus 로고    scopus 로고
    • Two distinct Vps34 phosphatidylinositol 3-kinase complexes function in autophagy and carboxypeptidase Y sorting in Saccharomyces cerevisiae
    • Kihara, A.; Noda, T.; Ishihara, N.; Ohsumi, Y. Two distinct Vps34 phosphatidylinositol 3-kinase complexes function in autophagy and carboxypeptidase Y sorting in Saccharomyces cerevisiae. J. Cell Biol. 2001, 752, 519-530.
    • (2001) J. Cell Biol , vol.752 , pp. 519-530
    • Kihara, A.1    Noda, T.2    Ishihara, N.3    Ohsumi, Y.4
  • 95
    • 33947401472 scopus 로고    scopus 로고
    • Autophagosome-lysosome fusion depends on the pH in acidic compartments in CHO cells
    • Kawai, A.; Uchiyama, H.; Takano, S.; Nakamura, N.; Ohkuma, S. Autophagosome-lysosome fusion depends on the pH in acidic compartments in CHO cells. Autophagy 2007, 3, 154-157.
    • (2007) Autophagy , vol.3 , pp. 154-157
    • Kawai, A.1    Uchiyama, H.2    Takano, S.3    Nakamura, N.4    Ohkuma, S.5
  • 96
    • 54349115389 scopus 로고    scopus 로고
    • Sensitization to radiation-induced DNA damage accelerates loss of Bcl-2 and increases apoptosis and autophagy
    • Rieber, M.; Rieber, M.S. Sensitization to radiation-induced DNA damage accelerates loss of Bcl-2 and increases apoptosis and autophagy. Cancer Biol. Ther. 2008, 7, 1561-1566.
    • (2008) Cancer Biol. Ther , vol.7 , pp. 1561-1566
    • Rieber, M.1    Rieber, M.S.2
  • 97
    • 33847008972 scopus 로고    scopus 로고
    • DNA damaging agent induced autophagy produces a cytoprotective adenosine triphosphate surge in malignant glioma cells
    • Katayama, M.; Kawaguchi, T.; Berger, M.S.; Pieper, R.O. DNA damaging agent induced autophagy produces a cytoprotective adenosine triphosphate surge in malignant glioma cells. Cell Death Differ. 2007, 74, 548-558.
    • (2007) Cell Death Differ , vol.74 , pp. 548-558
    • Katayama, M.1    Kawaguchi, T.2    Berger, M.S.3    Pieper, R.O.4
  • 98
    • 33847026354 scopus 로고    scopus 로고
    • Autophagy delays apoptotic death in breast cancer cells following DNA damage
    • Abedin, M.J.; Wang, D.; McDonnell, M.A.; Lehmann, U.; Kelekar, A. Autophagy delays apoptotic death in breast cancer cells following DNA damage. Cell Death Differ. 2007, 74, 500-510.
    • (2007) Cell Death Differ , vol.74 , pp. 500-510
    • Abedin, M.J.1    Wang, D.2    McDonnell, M.A.3    Lehmann, U.4    Kelekar, A.5
  • 99
    • 52049125696 scopus 로고    scopus 로고
    • Suppression of autophagy enhances the cytotoxicity of the DNA-damaging aromatic amine p-anilinoaniline
    • Elliott, A.; Reiners, J.J., Jr. Suppression of autophagy enhances the cytotoxicity of the DNA-damaging aromatic amine p-anilinoaniline. Toxicol. Appl. Pharmacol. 2008, 232, 169-179.
    • (2008) Toxicol. Appl. Pharmacol , vol.232 , pp. 169-179
    • Elliott, A.1    Reiners, J.J.2
  • 100
    • 40449086885 scopus 로고    scopus 로고
    • Blocked autophagy sensitizes resistant carcinoma cells to radiation therapy
    • Apel, A.; Herr, I.; Schwarz, H.; Rodemann, H.P.; Mayer, A. Blocked autophagy sensitizes resistant carcinoma cells to radiation therapy. Cancer Res. 2008, 68, 1485-1494.
    • (2008) Cancer Res , vol.68 , pp. 1485-1494
    • Apel, A.1    Herr, I.2    Schwarz, H.3    Rodemann, H.P.4    Mayer, A.5
  • 101
    • 56549116658 scopus 로고    scopus 로고
    • Macroautophagy inhibition sensitizes tamoxifen-resistant breast cancer cells and enhances mitochondrial depolarization
    • Qadir, M.A.; Kwok, B.; Dragowska, W.H.; To, K.H.; Le, D.; Bally, M.B.; Gorski, S.M. Macroautophagy inhibition sensitizes tamoxifen-resistant breast cancer cells and enhances mitochondrial depolarization. Breast Cancer Res. Treat. 2008, 772, 389-403.
    • (2008) Breast Cancer Res. Treat , vol.772 , pp. 389-403
    • Qadir, M.A.1    Kwok, B.2    Dragowska, W.H.3    To, K.H.4    Le, D.5    Bally, M.B.6    Gorski, S.M.7
  • 103
    • 84866540766 scopus 로고    scopus 로고
    • UVARG at the crossroad of autophagy and genomic stability
    • Zhao, Z.; Ni, D.; Ghozalli, I.; Piroz, S.D.; Ma, B.; Liang, C. UVARG at the crossroad of autophagy and genomic stability. Autophagy 2012, 8, 1392-1393.
    • (2012) Autophagy , vol.8 , pp. 1392-1393
    • Zhao, Z.1    Ni, D.2    Ghozalli, I.3    Piroz, S.D.4    Ma, B.5    Liang, C.6
  • 105
    • 77955448361 scopus 로고    scopus 로고
    • ATM engages the TSC2/mTORC1 signaling node to regulate autophagy
    • Alexander, A.; Kim, J.; Walker, C.L. ATM engages the TSC2/mTORC1 signaling node to regulate autophagy. Autophagy 2010, 6, 672-673.
    • (2010) Autophagy , vol.6 , pp. 672-673
    • Alexander, A.1    Kim, J.2    Walker, C.L.3
  • 107
    • 0345167800 scopus 로고    scopus 로고
    • TSC2 mediates cellular energy response to control cell growth and survival
    • Inoki, K.; Zhu, T.; Guan, K.L. TSC2 mediates cellular energy response to control cell growth and survival. Cell 2003, 775, 577-590.
    • (2003) Cell , vol.775 , pp. 577-590
    • Inoki, K.1    Zhu, T.2    Guan, K.L.3
  • 108
    • 79551507263 scopus 로고    scopus 로고
    • AMPK-dependent phosphorylation of ULK1 induces autophagy
    • Zhao, M.; Klionsky, D.J. AMPK-dependent phosphorylation of ULK1 induces autophagy. CellMetab. 2011, 73, 119-120.
    • (2011) Cellmetab , vol.73 , pp. 119-120
    • Zhao, M.1    Klionsky, D.J.2
  • 109
    • 43149111604 scopus 로고    scopus 로고
    • Functional interaction between FOXO3a and ATM regulates DNA damage response
    • Tsai, W.B.; Chung, Y.M.; Takahashi, Y.; Xu, Z.; Hu, M.C. Functional interaction between FOXO3a and ATM regulates DNA damage response. Nat. Cell Biol. 2008, 70, 460-467.
    • (2008) Nat. Cell Biol , vol.70 , pp. 460-467
    • Tsai, W.B.1    Chung, Y.M.2    Takahashi, Y.3    Xu, Z.4    Hu, M.C.5
  • 111
    • 65549139675 scopus 로고    scopus 로고
    • Regulation of the aging process by autophagy
    • Salminen, A.; Kaarniranta, K. Regulation of the aging process by autophagy. Trends Mol. Med. 2009, 75, 217-224.
    • (2009) Trends Mol. Med , vol.75 , pp. 217-224
    • Salminen, A.1    Kaarniranta, K.2
  • 112
    • 77953533500 scopus 로고    scopus 로고
    • The AMPK-FoxO3A axis as a target for cancer treatment
    • Chiacchiera, F.; Simone, C. The AMPK-FoxO3A axis as a target for cancer treatment. Cell Cycle 2010, 9, 1091-1096.
    • (2010) Cell Cycle , vol.9 , pp. 1091-1096
    • Chiacchiera, F.1    Simone, C.2
  • 114
    • 53649090627 scopus 로고    scopus 로고
    • P53 in autophagy control
    • Zong, W.X.; Moll, U. p53 in autophagy control. Cell Cycle 2008, 7, 2947-2948.
    • (2008) Cell Cycle , vol.7 , pp. 2947-2948
    • Zong, W.X.1    Moll, U.2
  • 115
    • 70350097409 scopus 로고    scopus 로고
    • Enhanced sensitivity of celecoxib in human glioblastoma cells: Induction of DNA damage leading to p53-dependent G1 cell cycle arrest and autophagy
    • Kang, K.B.; Zhu, C.; Yong, S.K.; Gao, Q.; Wong, M.C. Enhanced sensitivity of celecoxib in human glioblastoma cells: Induction of DNA damage leading to p53-dependent G1 cell cycle arrest and autophagy. Mol. Cancer 2009, 8, 66.
    • (2009) Mol. Cancer , vol.8 , pp. 66
    • Kang, K.B.1    Zhu, C.2    Yong, S.K.3    Gao, Q.4    Wong, M.C.5
  • 116
    • 20444363122 scopus 로고    scopus 로고
    • The coordinate regulation of the p53 and mTOR pathways in cells
    • Feng, Z.; Zhang, H.; Levine, A.J.; Jin, S. The coordinate regulation of the p53 and mTOR pathways in cells. Proc. Natl. Acad. Sci. USA 2005, 702, 8204-8209.
    • (2005) Proc. Natl. Acad. Sci. USA , vol.702 , pp. 8204-8209
    • Feng, Z.1    Zhang, H.2    Levine, A.J.3    Jin, S.4
  • 117
    • 75749157306 scopus 로고    scopus 로고
    • Mechanisms of dealing with DNA damage in terminally differentiated cells
    • Fortini, P.; Dogliotti, E. Mechanisms of dealing with DNA damage in terminally differentiated cells. Mutat. Res. 2010, 685, 38-44.
    • (2010) Mutat. Res , vol.685 , pp. 38-44
    • Fortini, P.1    Dogliotti, E.2
  • 118
    • 33947715833 scopus 로고    scopus 로고
    • P53, Autophagy and tumor suppression
    • Jin, S. p53, Autophagy and tumor suppression. Autophagy 2005, 7, 171-173.
    • (2005) Autophagy , vol.7 , pp. 171-173
    • Jin, S.1
  • 120
    • 33846260837 scopus 로고    scopus 로고
    • DRAM links autophagy to p53 and programmed cell death
    • Crighton, D.; Wilkinson, S.; Ryan, K.M. DRAM links autophagy to p53 and programmed cell death. Autophagy 2007, 3, 72-74.
    • (2007) Autophagy , vol.3 , pp. 72-74
    • Crighton, D.1    Wilkinson, S.2    Ryan, K.M.3
  • 121
    • 79952215577 scopus 로고    scopus 로고
    • Down-regulation of VRK1 by p53 in response to DNA damage is mediated by the autophagic pathway
    • Valbuena, A.; Castro-Obregon, S.; Lazo, P.A. Down-regulation of VRK1 by p53 in response to DNA damage is mediated by the autophagic pathway. PLoS One 2011, 6, e17320.
    • (2011) Plos One , vol.6
    • Valbuena, A.1    Castro-Obregon, S.2    Lazo, P.A.3
  • 122
    • 67650225155 scopus 로고    scopus 로고
    • Emerging biological functions of the vaccinia-related kinase (VRK) family
    • Klerkx, E.P.; Lazo, P.A.; Askjaer, P. Emerging biological functions of the vaccinia-related kinase (VRK) family. Histol. Histopathol. 2009, 24, 749-759.
    • (2009) Histol. Histopathol , vol.24 , pp. 749-759
    • Klerkx, E.P.1    Lazo, P.A.2    Askjaer, P.3
  • 124
    • 79954549252 scopus 로고    scopus 로고
    • Autophagy-dependent regulation of the DNA damage response protein ribonucleotide reductase 1
    • Dyavaiah, M.; Rooney, J.P.; Chittur, S.V.; Lin, Q.; Begley, T.J. Autophagy-dependent regulation of the DNA damage response protein ribonucleotide reductase 1. Mol. Cancer Res. 2011, 9, 462-475.
    • (2011) Mol. Cancer Res , vol.9 , pp. 462-475
    • Dyavaiah, M.1    Rooney, J.P.2    Chittur, S.V.3    Lin, Q.4    Begley, T.J.5
  • 125
    • 0033598713 scopus 로고    scopus 로고
    • Poly(ADP-ribose) polymerase is a mediator of necrotic cell death by ATP depletion
    • Ha, H.C.; Snyder, S.H. Poly(ADP-ribose) polymerase is a mediator of necrotic cell death by ATP depletion. Proc. Natl. Acad. Sci. USA 1999, 96, 13978-13982.
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 13978-13982
    • Ha, H.C.1    Snyder, S.H.2
  • 127
    • 34250891313 scopus 로고    scopus 로고
    • AMP-activated protein kinase: A universal regulator of autophagy?
    • Hoyer-Hansen, M.; Jaattela, M. AMP-activated protein kinase: A universal regulator of autophagy? Autophagy 2007, 3, 381-383.
    • (2007) Autophagy , vol.3 , pp. 381-383
    • Hoyer-Hansen, M.1    Jaattela, M.2
  • 129
    • 61649093766 scopus 로고    scopus 로고
    • To die or to live: The dual role of poly(ADP-ribose) polymerase-1 in autophagy and necrosis under oxidative stress and DNA damage
    • Huang, Q.; Shen, H.M. To die or to live: The dual role of poly(ADP-ribose) polymerase-1 in autophagy and necrosis under oxidative stress and DNA damage. Autophagy 2009, 5, 273-276.
    • (2009) Autophagy , vol.5 , pp. 273-276
    • Huang, Q.1    Shen, H.M.2
  • 130
    • 84862777879 scopus 로고    scopus 로고
    • Role of autophagy in chemoresistance: Regulation of the ATM-mediated DNA-damage signaling pathway through activation of DNA-PKcs and PARP-1
    • Yoon, J.H.; Ahn, S.G.; Lee, B.H.; Jung, S.H.; Oh, S.H. Role of autophagy in chemoresistance: Regulation of the ATM-mediated DNA-damage signaling pathway through activation of DNA-PKcs and PARP-1. Biochem. Pharmacol. 2012, 83, 747-757.
    • (2012) Biochem. Pharmacol , vol.83 , pp. 747-757
    • Yoon, J.H.1    Ahn, S.G.2    Lee, B.H.3    Jung, S.H.4    Oh, S.H.5
  • 132
    • 81555226055 scopus 로고    scopus 로고
    • Sirtuins: Molecular traffic lights in the crossroad of oxidative stress, chromatin remodeling, and transcription
    • Rajendran, R.; Garva, R.; Krstic-Demonacos, M.; Demonacos, C. Sirtuins: Molecular traffic lights in the crossroad of oxidative stress, chromatin remodeling, and transcription. J. Biomed. Biotechnol. 2011, 2077, 368276.
    • (2011) J. Biomed. Biotechnol , vol.2077
    • Rajendran, R.1    Garva, R.2    Krstic-Demonacos, M.3    Demonacos, C.4
  • 133
    • 84872008953 scopus 로고    scopus 로고
    • Sirtuins and renal diseases: Relationship with aging and diabetic nephropathy
    • Kitada, M.; Kume, S.; Takeda-Watanabe, A.; Kanasaki, K.; Koya, D. Sirtuins and renal diseases: Relationship with aging and diabetic nephropathy. Clin. Sci. 2013, 724, 153-164.
    • (2013) Clin. Sci , vol.724 , pp. 153-164
    • Kitada, M.1    Kume, S.2    Takeda-Watanabe, A.3    Kanasaki, K.4    Koya, D.5
  • 134
    • 78650691023 scopus 로고    scopus 로고
    • Deacetylation of FoxO by Sirt1 plays an essential role in mediating starvation-induced autophagy in cardiac myocytes
    • Hariharan, N.; Maejima, Y.; Nakae, J.; Paik, J.; Depinho, R.A.; Sadoshima, J. Deacetylation of FoxO by Sirt1 plays an essential role in mediating starvation-induced autophagy in cardiac myocytes. Circ. Res. 2010, 707, 1470-1482.
    • (2010) Circ. Res , vol.707 , pp. 1470-1482
    • Hariharan, N.1    Maejima, Y.2    Nakae, J.3    Paik, J.4    Depinho, R.A.5    Sadoshima, J.6
  • 135
    • 77953577017 scopus 로고    scopus 로고
    • MTOR's role in ageing: Protein synthesis or autophagy?
    • Hands, S.L.; Proud, C.G.; Wyttenbach, A. mTOR's role in ageing: Protein synthesis or autophagy? Aging 2009, 7, 586-597.
    • (2009) Aging , vol.7 , pp. 586-597
    • Hands, S.L.1    Proud, C.G.2    Wyttenbach, A.3
  • 136
    • 77953292238 scopus 로고    scopus 로고
    • SIRT1 and p53, effect on cancer, senescence and beyond
    • Yi, J.; Luo, J. SIRT1 and p53, effect on cancer, senescence and beyond. Biochim. Biophys. Acta 2010, 7804, 1684-1689.
    • (2010) Biochim. Biophys. Acta , vol.7804 , pp. 1684-1689
    • Yi, J.1    Luo, J.2
  • 137
    • 0034678330 scopus 로고    scopus 로고
    • Suppression of Pyk2 kinase and cellular activities by FIP200
    • Ueda, H.; Abbi, S.; Zheng, C.; Guan, J.L. Suppression of Pyk2 kinase and cellular activities by FIP200. J. Cell Biol. 2000, 749, 423-430.
    • (2000) J. Cell Biol , vol.749 , pp. 423-430
    • Ueda, H.1    Abbi, S.2    Zheng, C.3    Guan, J.L.4
  • 138
    • 23744454765 scopus 로고    scopus 로고
    • Identification of FIP200 interaction with the TSC1-TSC2 complex and its role in regulation of cell size control
    • Gan, B.; Melkoumian, Z.K.; Wu, X.; Guan, K.L.; Guan, J.L. Identification of FIP200 interaction with the TSC1-TSC2 complex and its role in regulation of cell size control. J. Cell Biol. 2005, 770, 379-389.
    • (2005) J. Cell Biol , vol.770 , pp. 379-389
    • Gan, B.1    Melkoumian, Z.K.2    Wu, X.3    Guan, K.L.4    Guan, J.L.5
  • 139
    • 23044453057 scopus 로고    scopus 로고
    • Mechanism of cell cycle regulation by FIP200 in human breast cancer cells
    • Melkoumian, Z.K.; Peng, X.; Gan, B.; Wu, X.; Guan, J.L. Mechanism of cell cycle regulation by FIP200 in human breast cancer cells. Cancer Res. 2005, 65, 6676-6684.
    • (2005) Cancer Res , vol.65 , pp. 6676-6684
    • Melkoumian, Z.K.1    Peng, X.2    Gan, B.3    Wu, X.4    Guan, J.L.5
  • 140
    • 33749562122 scopus 로고    scopus 로고
    • Role of FIP200 in cardiac and liver development and its regulation of TNFa and TSC-mTOR signaling pathways
    • Gan, B.; Peng, X.; Nagy, T.; Alcaraz, A.; Gu, H.; Guan, J.L. Role of FIP200 in cardiac and liver development and its regulation of TNFa and TSC-mTOR signaling pathways. J. Cell Biol. 2006, 775, 121-133.
    • (2006) J. Cell Biol , vol.775 , pp. 121-133
    • Gan, B.1    Peng, X.2    Nagy, T.3    Alcaraz, A.4    Gu, H.5    Guan, J.L.6
  • 141
    • 66449083078 scopus 로고    scopus 로고
    • ULK1-ATG13-FIP200 complex mediates mTOR signaling and is essential for autophagy
    • Ganley, I.G.; du Lam, H.; Wang, J.; Ding, X.; Chen, S.; Jiang, X. ULK1-ATG13-FIP200 complex mediates mTOR signaling and is essential for autophagy. J. Biol. Chem. 2009, 284, 12297-12305.
    • (2009) J. Biol. Chem , vol.284 , pp. 12297-12305
    • Ganley, I.G.1    Du Lam, H.2    Wang, J.3    Ding, X.4    Chen, S.5    Jiang, X.6
  • 145
    • 80052841386 scopus 로고    scopus 로고
    • Suppression of autophagy by FIP200 deletion impairs DNA damage repair and increases cell death upon treatments with anticancer agents
    • Bae, H.; Guan, J.L. Suppression of autophagy by FIP200 deletion impairs DNA damage repair and increases cell death upon treatments with anticancer agents. Mol. Cancer Res. 2011, 9, 1232-1241.
    • (2011) Mol. Cancer Res , vol.9 , pp. 1232-1241
    • Bae, H.1    Guan, J.L.2
  • 146
    • 33846692198 scopus 로고    scopus 로고
    • Signal integration and diversification through the p62 scaffold protein
    • Moscat, J.; Diaz-Meco, M.T.; Wooten, M.W. Signal integration and diversification through the p62 scaffold protein. Trends Biochem. Sci. 2007, 32, 95-100.
    • (2007) Trends Biochem. Sci , vol.32 , pp. 95-100
    • Moscat, J.1    Diaz-Meco, M.T.2    Wooten, M.W.3
  • 147
    • 0029809134 scopus 로고    scopus 로고
    • P62, a phosphotyrosine-independent ligand of the SH2 domain of p56lck, belongs to a new class of ubiquitin-binding proteins
    • Vadlamudi, R.K.; Joung, I.; Strominger, J.L.; Shin, J. p62, a phosphotyrosine-independent ligand of the SH2 domain of p56lck, belongs to a new class of ubiquitin-binding proteins. J. Biol. Chem. 1996, 277, 20235-20237.
    • (1996) J. Biol. Chem , vol.277 , pp. 20235-20237
    • Vadlamudi, R.K.1    Joung, I.2    Strominger, J.L.3    Shin, J.4
  • 148
    • 58149344946 scopus 로고    scopus 로고
    • Midbody ring disposal by autophagy is a post-abscission event of cytokinesis
    • Pohl, C.; Jentsch, S. Midbody ring disposal by autophagy is a post-abscission event of cytokinesis. Nat. Cell Biol. 2009, 77, 65-70.
    • (2009) Nat. Cell Biol , vol.77 , pp. 65-70
    • Pohl, C.1    Jentsch, S.2
  • 151
    • 77949324195 scopus 로고    scopus 로고
    • Nucleocytoplasmic shuttling of p62/SQSTM1 and its role in recruitment of nuclear polyubiquitinated proteins to promyelocytic leukemia bodies
    • Pankiv, S.; Lamark, T.; Bruun, J.A.; 0vervatn, A.; Bj0rk0y, G.; Johansen, T. Nucleocytoplasmic shuttling of p62/SQSTM1 and its role in recruitment of nuclear polyubiquitinated proteins to promyelocytic leukemia bodies. J. Biol. Chem. 2010, 285, 5941-5953.
    • (2010) J. Biol. Chem. , vol.285 , pp. 5941-5953
    • Pankiv, S.1    Lamark, T.2    Bruun, J.A.3    0Vervatn, A.4    Bj0rk0y, G.5    Johansen, T.6
  • 154
    • 0004235430 scopus 로고    scopus 로고
    • 2nd ed.; Wiley: Hoboken, NJ, USA
    • Scheffler, I.E. Mitochondria, 2nd ed.; Wiley: Hoboken, NJ, USA, 2008.
    • (2008) Mitochondria
    • Scheffler, I.E.1
  • 157
    • 0000730374 scopus 로고
    • Cytoplasmic components in hepatic cell lysosomes
    • Ashford, T.P.; Porter, K.R. Cytoplasmic components in hepatic cell lysosomes. J. Cell Biol. 1962, 72, 198-202.
    • (1962) J. Cell Biol , vol.72 , pp. 198-202
    • Ashford, T.P.1    Porter, K.R.2
  • 159
    • 77956252454 scopus 로고    scopus 로고
    • Nix is critical to two distinct phases of mitophagy, reactive oxygen species-mediated autophagy induction and Parkin-ubiquitin-p62-mediated mitochondrial priming
    • Ding, W.X.; Ni, H.M.; Li, M.; Liao, Y.; Chen, X.; Stolz, D.B.; Dorn, G.W. II.; Yin, X.M. Nix is critical to two distinct phases of mitophagy, reactive oxygen species-mediated autophagy induction and Parkin-ubiquitin-p62-mediated mitochondrial priming. J. Biol. Chem. 2010, 285, 27879-27890.
    • (2010) J. Biol. Chem. , vol.285 , pp. 27879-27890
    • Ding, W.X.1    Ni, H.M.2    Li, M.3    Liao, Y.4    Chen, X.5    Stolz, D.B.6    Dorn, G.W.7    Yin, X.M.8
  • 162
    • 58149314211 scopus 로고    scopus 로고
    • Parkin is recruited selectively to impaired mitochondria and promotes their autophagy
    • Narendra, D.; Tanaka, A.; Suen, D.F.; Youle, R.J. Parkin is recruited selectively to impaired mitochondria and promotes their autophagy. J. Cell Biol. 2008, 783, 795-803.
    • (2008) J. Cell Biol. , vol.783 , pp. 795-803
    • Narendra, D.1    Tanaka, A.2    Suen, D.F.3    Youle, R.J.4
  • 164
    • 53149087460 scopus 로고    scopus 로고
    • Mitochondrial alterations in Parkinson's disease: New clues
    • Vila, M.; Ramonet, D.; Perier, C. Mitochondrial alterations in Parkinson's disease: New clues. J. Neurochem. 2008, 707, 317-328.
    • (2008) J. Neurochem , vol.707 , pp. 317-328
    • Vila, M.1    Ramonet, D.2    Perier, C.3
  • 165
    • 45149107487 scopus 로고    scopus 로고
    • Mechanisms of neurodegeneration in Huntington's disease
    • Gil, J.M.; Rego, A.C. Mechanisms of neurodegeneration in Huntington's disease. Eur. J. Neurosci. 2008, 27, 2803-2820.
    • (2008) Eur. J. Neurosci , vol.27 , pp. 2803-2820
    • Gil, J.M.1    Rego, A.C.2
  • 166
    • 84872604143 scopus 로고    scopus 로고
    • UVC-induced mitochondrial degradation via autophagy correlates with mtDNA damage removal in primary human fibroblasts
    • Bess, A.S.; Ryde, I.T.; Hinton, D.E.; Meyer, J.N. UVC-induced mitochondrial degradation via autophagy correlates with mtDNA damage removal in primary human fibroblasts. J. Biochem. Mol. Toxicol. 2013, 27, 28-41.
    • (2013) J. Biochem. Mol. Toxicol , vol.27 , pp. 28-41
    • Bess, A.S.1    Ryde, I.T.2    Hinton, D.E.3    Meyer, J.N.4
  • 169
  • 172
    • 27944482199 scopus 로고    scopus 로고
    • Impairing the bioenergetic status and the biogenesis of mitochondria triggers mitophagy in yeast
    • Priault, M.; Salin, B.; Schaeffer, J.; Vallette, F.M.; di Rago, J.P.; Martinou, J.C. Impairing the bioenergetic status and the biogenesis of mitochondria triggers mitophagy in yeast. Cell Death Differ. 2005, 72, 1613-1621.
    • (2005) Cell Death Differ , vol.72 , pp. 1613-1621
    • Priault, M.1    Salin, B.2    Schaeffer, J.3    Vallette, F.M.4    Di Rago, J.P.5    Martinou, J.C.6
  • 173
    • 0035487007 scopus 로고    scopus 로고
    • The mitochondrial permeability transition initiates autophagy in rat hepatocytes
    • Elmore, S.P.; Qian, T.; Grissom, S.F.; Lemasters, J.J. The mitochondrial permeability transition initiates autophagy in rat hepatocytes. FASEB J. 2001, 75, 2286-2287.
    • (2001) FASEB J , vol.75 , pp. 2286-2287
    • Elmore, S.P.1    Qian, T.2    Grissom, S.F.3    Lemasters, J.J.4
  • 174
    • 8844239959 scopus 로고    scopus 로고
    • Effect of IGF-1 on the balance between autophagy of dysfunctional mitochondria and apoptosis
    • Gu, Y.; Wang, C.; Cohen, A. Effect of IGF-1 on the balance between autophagy of dysfunctional mitochondria and apoptosis. FEBSLett. 2004, 577, 357-360.
    • (2004) Febslett , vol.577 , pp. 357-360
    • Gu, Y.1    Wang, C.2    Cohen, A.3
  • 176
    • 7744235672 scopus 로고    scopus 로고
    • Death by design: Apoptosis, necrosis and autophagy
    • Edinger, A.L.; Thompson, C.B. Death by design: Apoptosis, necrosis and autophagy. Curr. Opin. Cell Biol. 2004, 76, 663-669.
    • (2004) Curr. Opin. Cell Biol , vol.76 , pp. 663-669
    • Edinger, A.L.1    Thompson, C.B.2
  • 177
  • 179
    • 84884812963 scopus 로고    scopus 로고
    • Targeting autophagy as a potential therapeutic approach for melanoma therapy. Semin
    • Liu, H.; He, Z.; Simon, H.U. Targeting autophagy as a potential therapeutic approach for melanoma therapy. Semin. Cancer Biol. 2013, 23, 352-360.
    • (2013) Cancer Biol , vol.23 , pp. 352-360
    • Liu, H.1    He, Z.2    Simon, H.U.3
  • 180
    • 84875251503 scopus 로고    scopus 로고
    • The role of autophagy in liver cancer: Molecular mechanisms and potential therapeutic targets
    • Cui, J.; Gong, Z.; Shen, H.M. The role of autophagy in liver cancer: Molecular mechanisms and potential therapeutic targets. Biochim. Biophys. Acta 2013, 7836, 15-26.
    • (2013) Biochim. Biophys. Acta , vol.7836 , pp. 15-26
    • Cui, J.1    Gong, Z.2    Shen, H.M.3


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