Signal integration and diversification through the p62 scaffold protein

Trends in Biochemical Sciences

Volumn 32, Issue 2, 2007, Pages 95-100

  Moscat, Jorge ^a   Diaz Meco, María T ^a   Wooten, Marie W ^b  

^a UNIVERSITY OF CINCINNATI   (United States)

^b AUBURN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; NEUROTROPHIN; PROTEIN KINASE; PROTEIN P62; SCAFFOLD PROTEIN; SEQUESTOSOME 1; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 6; UBIQUITIN; UNCLASSIFIED DRUG;

CELL DIFFERENTIATION; GENE INACTIVATION; HUMAN; INFLAMMATION; NONHUMAN; OBESITY; OSTEOCLAST; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN PROTEIN INTERACTION; REVIEW; SIGNAL TRANSDUCTION; UBIQUITINATION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; CARRIER PROTEINS; HUMANS; NF-KAPPA B; NUCLEAR PROTEINS; SIGNAL TRANSDUCTION; TNF RECEPTOR-ASSOCIATED FACTOR 6; TRANSCRIPTION FACTORS; UBIQUITIN;

MUS;

EID: 33846692198     PISSN: 09680004     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tibs.2006.12.002     Document Type: Review

References (41)

1. Moscat J., and Diaz-Meco M.T. The atypical protein kinase Cs. Functional specificity mediated by specific protein adapters. EMBO Rep. 1 (2000) 399-403
2. Sanchez P., et al. Localization of atypical protein kinase C isoforms into lysosome-targeted endosomes through interaction with p62. Mol. Cell. Biol. 18 (1998) 3069-3080
3. Puls A., et al. Interaction of protein kinase Cζ with ZIP, a novel protein kinase C-binding protein. Proc. Natl. Acad. Sci. U. S. A. 94 (1997) 6191-6196
4. Duran A., et al. The atypical PKC-interacting protein p62 is an important mediator of RANK-activated osteoclastogenesis. Dev. Cell 6 (2004) 303-309
5. Sanz L., et al. The atypical PKC-interacting protein p62 channels NF-κB activation by the IL-1-TRAF6 pathway. EMBO J. 19 (2000) 1576-1586
6. Boyle W.J., et al. Osteoclast differentiation and activation. Nature 423 (2003) 337-342
7. Moscat J., et al. Cell signaling and function organized by PB1 domain interactions. Mol. Cell 23 (2006) 631-640
8. Sanz L., et al. The interaction of p62 with RIP links the atypical PKCs to NF-κB activation. EMBO J. 18 (1999) 3044-3053
9. Laurin N., et al. Recurrent mutation of the gene encoding sequestosome 1 (SQSTM1/p62) in Paget disease of bone. Am. J. Hum. Genet. 70 (2002) 1582-1588
10. Harper J.W., and Schulman B.A. Structural complexity in ubiquitin recognition. Cell 124 (2006) 1133-1136
11. Layfield R., et al. p62 mutations, ubiquitin recognition and Paget's disease of bone. Biochem. Soc. Trans. 34 (2006) 735-737
12. Soriano P., et al. Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice. Cell 64 (1991) 693-702
13. Gravallese E., et al. The role of TNF-receptor family members and other TRAF-dependent receptors in bone resorption. Arthritis Res. 3 (2001) 6-12
14. Teitelbaum S.L., and Ross F.P. Genetic regulation of osteoclast development and function. Nat. Rev. Genet. 4 (2003) 638-649
15. Duran A., et al. Crosstalk between PKCζ and the IL4/Stat6 pathway during T-cell-mediated hepatitis. EMBO J. 23 (2004) 4595-4605
16. Ghosh S., and Karin M. Missing pieces in the NF-κB puzzle. Cell 109 Suppl. (2002) S81-S96
17. Chen Z.J. Ubiquitin signalling in the NF-κB pathway. Nat. Cell Biol. 7 (2005) 758-765
18. Lallena M.J., et al. Activation of IκB kinase β by protein kinase C isoforms. Mol. Cell. Biol. 19 (1999) 2180-2188
19. Martin P., et al. Role of ζPKC in B-cell signaling and function. EMBO J. 21 (2002) 4049-4057
20. Leitges M., et al. Targeted disruption of the ζPKC gene results in the impairment of the NF-κB pathway. Mol. Cell 8 (2001) 771-780
21. Wooten M.W., et al. The atypical protein kinase C-interacting protein p62 is a scaffold for NF-κB activation by nerve growth factor. J. Biol. Chem. 276 (2001) 7709-7712
22. Wooten M.W., et al. The p62 scaffold regulates nerve growth factor-induced NF-κB activation by influencing TRAF6 polyubiquitination. J. Biol. Chem. 280 (2005) 35625-35629
23. Sun L., et al. The TRAF6 ubiquitin ligase and TAK1 kinase mediate IKK activation by BCL10 and MALT1 in T lymphocytes. Mol. Cell 14 (2004) 289-301
24. Kanayama A., et al. TAB2 and TAB3 activate the NF-κB pathway through binding to polyubiquitin chains. Mol. Cell 15 (2004) 535-548
25. Martin P., et al. The signaling adapter p62 is an important mediator of T helper 2 cell function and allergic airway inflammation. EMBO J. 25 (2006) 3524-3533
26. Luster A.D., and Tager A.M. T-cell trafficking in asthma: lipid mediators grease the way. Nat. Rev. Immunol. 4 (2004) 711-724
27. Paul W.E., and Seder R.A. Lymphocyte responses and cytokines. Cell 76 (1994) 241-251
28. Murphy K.M., and Reiner S.L. The lineage decisions of helper T cells. Nat. Rev. Immunol. 2 (2002) 933-944
29. Martin P., et al. Control of T helper 2 cell function and allergic airway inflammation by PKCζ. Proc. Natl. Acad. Sci. U. S. A. 102 (2005) 9866-9871
30. Geetha T., and Wooten M.W. Association of the atypical protein kinase C-interacting protein p62/ZIP with nerve growth factor receptor TrkA regulates receptor trafficking and Erk5 signaling. J. Biol. Chem. 278 (2003) 4730-4739
31. Geetha T., et al. Lysine 63 polyubiquitination of the nerve growth factor receptor TrkA directs internalization and signaling. Mol. Cell 20 (2005) 301-312
32. Rodriguez A., et al. Mature-onset obesity and insulin resistance in mice deficient in the signaling adapter p62. Cell Metab. 3 (2006) 211-222
33. Flier J.S. Obesity wars: molecular progress confronts an expanding epidemic. Cell 116 (2004) 337-350
34. Bost F., et al. The extracellular signal-regulated kinase isoform ERK1 is specifically required for in vitro and in vivo adipogenesis. Diabetes 54 (2005) 402-411
35. Carlson C.J., et al. Enhanced basal activation of mitogen-activated protein kinases in adipocytes from type 2 diabetes: potential role of p38 in the downregulation of GLUT4 expression. Diabetes 52 (2003) 634-641
36. Novack D.V., et al. The IκB function of NF-κB2 p100 controls stimulated osteoclastogenesis. J. Exp. Med. 198 (2003) 771-781
37. Hu E., et al. Inhibition of adipogenesis through MAP kinase-mediated phosphorylation of PPARγ. Science 274 (1996) 2100-2103
38. Wilson M.I., et al. PB1 domain-mediated heterodimerization in NADPH oxidase and signaling complexes of atypical protein kinase C with Par6 and p62. Mol. Cell 12 (2003) 39-50
39. Nakamura K., et al. PB1 domain-dependent signaling complex is required for extracellular signal-regulated kinase 5 activation. Mol. Cell. Biol. 26 (2006) 2065-2079
40. Seyfried J., et al. A novel mitogen-activated protein kinase docking site in the N terminus of MEK5α organizes the components of the extracellular signal-regulated kinase 5 signaling pathway. Mol. Cell. Biol. 25 (2005) 9820-9828
41. Lebrun B., et al. Brain-derived neurotrophic factor (BDNF) and food intake regulation: a minireview. Auton. Neurosci. 126-127 (2006) 30-38