Cetuximab augments cytotoxicity with poly (ADP-Ribose) polymerase inhibition in head and neck cancer

PLoS ONE

Volumn 6, Issue 8, 2011, Pages

  Nowsheen, Somaira ^a   Bonner, James A ^a   LoBuglio, Albert F ^a   Trummell, Hoa ^a   Whitley, Alexander C ^a   Dobelbower, Michael C ^a   Yang, Eddy S ^a,b,c  

^a UNIVERSITY OF ALABAMA SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^c University of Alabama at Birmingham   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CETUXIMAB; DNA; DOUBLE STRANDED DNA; EPIDERMAL GROWTH FACTOR RECEPTOR; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR; VELIPARIB; 2 ((R) 2 METHYLPYRROLIDIN 2 YL) 1H BENZIMIDAZOLE 4 CARBOXAMIDE; 2-((R)-2-METHYLPYRROLIDIN-2-YL)-1H-BENZIMIDAZOLE-4-CARBOXAMIDE; BENZIMIDAZOLE DERIVATIVE; MONOCLONAL ANTIBODY; PROTEIN KINASE INHIBITOR;

APOPTOSIS; ARTICLE; CANCER SURVIVAL; CELL CYCLE; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; DNA STRAND BREAKAGE; DRUG CYTOTOXICITY; DRUG POTENTIATION; ENZYME INHIBITION; HEAD AND NECK CANCER; HOMOLOGOUS RECOMBINATION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOFLUORESCENCE; DNA END JOINING REPAIR; DRUG ANTAGONISM; DRUG EFFECT; HEAD AND NECK TUMOR; PATHOLOGY; TUMOR CELL LINE;

ANTIBODIES, MONOCLONAL; APOPTOSIS; BENZIMIDAZOLES; CELL LINE, TUMOR; DNA DAMAGE; DNA END-JOINING REPAIR; DRUG SYNERGISM; HEAD AND NECK NEOPLASMS; HOMOLOGOUS RECOMBINATION; HUMANS; POLY(ADP-RIBOSE) POLYMERASES; PROTEIN KINASE INHIBITORS; RECEPTOR, EPIDERMAL GROWTH FACTOR;

EID: 80052288059     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0024148     Document Type: Article

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