-
1
-
-
37649005234
-
Autophagy in the pathogenesis of disease
-
Levine B, Kroemer G. Autophagy in the pathogenesis of disease. Cell 2008; 132:27-42.
-
(2008)
Cell
, vol.132
, pp. 27-42
-
-
Levine, B.1
Kroemer, G.2
-
2
-
-
0034329418
-
Lc3, a mammalian homologue of yeast apg8p, is localized in autophagosome membranes after processing
-
Kabeya Y, Mizushima N, Ueno T, et al. LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. EMBO J 2000; 19:5720-5728.
-
(2000)
EMBO J
, vol.19
, pp. 5720-5728
-
-
Kabeya, Y.1
Mizushima, N.2
Ueno, T.3
-
3
-
-
33745867638
-
Poly(ADP-ribose): Novel functions for an old molecule
-
DOI 10.1038/nrm1963, PII NRM1963
-
Schreiber V, Dantzer F, Ame JC, de Murcia G. Poly(ADPribose): novel functions for an old molecule. Nat Rev Mol Cell Biol 2006; 7:517-528. (Pubitemid 44036457)
-
(2006)
Nature Reviews Molecular Cell Biology
, vol.7
, Issue.7
, pp. 517-528
-
-
Schreiber, V.1
Dantzer, F.2
Ame, J.-C.3
De Murcia, G.4
-
4
-
-
63849115360
-
Parthanatos, a messenger of death
-
David KK, Andrabi SA, Dawson TM, Dawson VL. Parthanatos, a messenger of death. Front Biosci 2009; 14:1116-1128.
-
(2009)
Front Biosci
, vol.14
, pp. 1116-1128
-
-
David, K.K.1
Andrabi, S.A.2
Dawson, T.M.3
Dawson, V.L.4
-
5
-
-
67649526000
-
Poly(adp-ribose) signals to mitochondrial aif: A key event in parthanatos
-
Wang Y, Dawson VL, Dawson TM. Poly(ADP-ribose) signals to mitochondrial AIF: a key event in parthanatos. Exp Neurol 2009; 218:193-202.
-
(2009)
Exp Neurol
, vol.218
, pp. 193-202
-
-
Wang, Y.1
Dawson, V.L.2
Dawson, T.M.3
-
7
-
-
8044257699
-
The phosphatidylinositol 3-kinase inhibitors wortmannin and LY294002 inhibit in isolated rat hepatocytes
-
Blommaart EF, Krause U, Schellens JP, Vreeling-Sindelarova H, Meijer AJ. The phosphatidylinositol 3-kinase inhibitors wortmannin and LY294002 inhibit autophagy in isolated rat hepatocytes. Eur J Biochem 1997; 243:240-246. (Pubitemid 27060408)
-
(1997)
European Journal of Biochemistry
, vol.243
, Issue.1-2
, pp. 240-246
-
-
Blommaart, E.F.C.1
Krause, U.2
Schellens, J.P.M.3
Vreeling-Sindelarova, H.4
Meijer, A.J.5
-
8
-
-
77954274504
-
The parp side of the nucleus: Molecular actions, physiological outcomes, and clinical tar gets
-
Krishnakumar R, Kraus WL. The PARP side of the nucleus: molecular actions, physiological outcomes, and clinical tar gets. Mol Cell 2010; 39:8-24.
-
(2010)
Mol Cell
, vol.39
, pp. 8-24
-
-
Krishnakumar, R.1
Kraus, W.L.2
-
9
-
-
34247186472
-
Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4
-
DOI 10.1038/sj.emboj.7601623, PII 7601623
-
Scherz-Shouval R, Shvets E, Fass E, Shorer H, Gil L, Elazar Z. Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4. EMBO J 2007; 26:1749-1760. (Pubitemid 46624042)
-
(2007)
EMBO Journal
, vol.26
, Issue.7
, pp. 1749-1760
-
-
Scherz-Shouval, R.1
Shvets, E.2
Fass, E.3
Shorer, H.4
Gil, L.5
Elazar, Z.6
-
10
-
-
67549084381
-
Superoxide is the major reactive oxygen species regulating autophagy
-
Chen Y, Azad MB, Gibson SB. Superoxide is the major reactive oxygen species regulating autophagy. Cell Death Differ 2009; 16:1040-1052.
-
(2009)
Cell Death Differ
, vol.16
, pp. 1040-1052
-
-
Chen, Y.1
Azad, M.B.2
Gibson, S.B.3
-
11
-
-
0026554428
-
Evaluation of the probe 2',7'-dichlorofluorescin as an indicator of reactive oxygen species formation and oxidative stress
-
LeBel CP, Ischiropoulos H, Bondy SC. Evaluation of the probe 2',7'-dichlorofluorescin as an indicator of reactive oxygen species formation and oxidative stress. Chem Res Toxicol 1992; 5:227-231.
-
(1992)
Chem Res Toxicol
, vol.5
, pp. 227-231
-
-
LeBel, C.P.1
Ischiropoulos, H.2
Bondy, S.C.3
-
12
-
-
0032193692
-
Poly(adp-ribose) synthetase activation mediates mitochondrial injury during oxidantinduced cell death
-
Virag L, Salzman AL, Szabo C. Poly(ADP-ribose) synthetase activation mediates mitochondrial injury during oxidantinduced cell death. J Immunol 1998; 161:3753-3759.
-
J Immunol
, vol.1998
, Issue.161
, pp. 3753-3759
-
-
Virag, L.1
Salzman, A.L.2
Szabo, C.3
-
13
-
-
4043171462
-
Upstream and downstream of mTOR
-
DOI 10.1101/gad.1212704
-
Hay N, Sonenberg N. Upstream and downstream of mTOR. Genes Dev 2004; 18:1926-1945. (Pubitemid 39071573)
-
(2004)
Genes and Development
, vol.18
, Issue.16
, pp. 1926-1945
-
-
Hay, N.1
Sonenberg, N.2
-
14
-
-
34250891313
-
AMP-activated protein kinase: A universal regulator of autophagy?
-
Hoyer-Hansen M, Jaattela M. AMP-activated protein kinase: a universal regulator of autophagy? Autophagy 2007; 3:381-383. (Pubitemid 46986350)
-
(2007)
Autophagy
, vol.3
, Issue.4
, pp. 381-383
-
-
Hoyer-Hansen, M.1
Jaattela, M.2
-
15
-
-
3142594193
-
The LKB1 tumor suppressor negatively regulates mTOR signaling
-
DOI 10.1016/j.ccr.2004.06.007, PII S1535610804001771
-
Shaw RJ, Bardeesy N, Manning BD, et al. The LKB1 tumor suppressor negatively regulates mTOR signaling. Cancer Cell 2004; 6:91-99. (Pubitemid 38903165)
-
(2004)
Cancer Cell
, vol.6
, Issue.1
, pp. 91-99
-
-
Shaw, R.J.1
Bardeesy, N.2
Manning, B.D.3
Lopez, L.4
Kosmatka, M.5
DePinho, R.A.6
Cantley, L.C.7
-
16
-
-
41149105722
-
Mitochondria in cancer cells: What is so special about them?
-
Gogvadze V, Orrenius S, Zhivotovsky B. Mitochondria in cancer cells: what is so special about them? Trends Cell Biol 2008; 18:165-173.
-
(2008)
Trends Cell Biol
, vol.18
, pp. 165-173
-
-
Gogvadze, V.1
Orrenius, S.2
Zhivotovsky, B.3
-
17
-
-
77955301066
-
The nadh-fumarate reductase system, a novel mitochondrial energy metabolism, is a new target for anticancer therapy in tumor microenvironments
-
Tomitsuka E, Kita K, Esumi H. The NADH-fumarate reductase system, a novel mitochondrial energy metabolism, is a new target for anticancer therapy in tumor microenvironments. Ann N Y Acad Sci 2010; 1201:44-49.
-
(2010)
Ann N Y Acad Sci
, vol.1201
, pp. 44-49
-
-
Tomitsuka, E.1
Kita, K.2
Esumi, H.3
-
18
-
-
56749170677
-
Autophagic cell death: The story of a misnomer
-
Kroemer G, Levine B. Autophagic cell death: the story of a misnomer. Nat Rev Mol Cell Biol 2008; 9:1004-1010.
-
(2008)
Nat Rev Mol Cell Biol
, vol.9
, pp. 1004-1010
-
-
Kroemer, G.1
Levine, B.2
-
19
-
-
25144506835
-
Autophagy in cell death: An innocent convict?
-
DOI 10.1172/JCI26390
-
Levine B, Yuan J. Autophagy in cell death: an innocent convict? J Clin Investig 2005; 115:2679-2688. (Pubitemid 41434392)
-
(2005)
Journal of Clinical Investigation
, vol.115
, Issue.10
, pp. 2679-2688
-
-
Levine, B.1
Yuan, J.2
-
20
-
-
20344387475
-
Autophagy: Dual roles in life and death?
-
DOI 10.1038/nrm1666
-
Baehrecke EH. Autophagy: dual roles in life and death? Nat Rev 2005; 6:505-510. (Pubitemid 40780562)
-
(2005)
Nature Reviews Molecular Cell Biology
, vol.6
, Issue.6
, pp. 505-510
-
-
Baehrecke, E.H.1
-
21
-
-
19944434059
-
Inhibition of macroautophagy triggers apoptosis
-
DOI 10.1128/MCB.25.3.1025-1040.2005
-
Boya P, Gonzalez-Polo RA, Casares N, et al. Inhibition of macroautophagy triggers apoptosis. Mol Cell Biol 2005; 25:1025-1040. (Pubitemid 40165810)
-
(2005)
Molecular and Cellular Biology
, vol.25
, Issue.3
, pp. 1025-1040
-
-
Boya, P.1
Gonzalez-Polo, R.-A.2
Casares, N.3
Perfettini, J.-L.4
Dessen, P.5
Larochette, N.6
Metivier, D.7
Meley, D.8
Souquere, S.9
Yoshimori, T.10
Pierron, G.11
Codogno, P.12
Kroemer, G.13
-
22
-
-
77954656984
-
Glucose deprivation induces an atypical form of apoptosis mediated by caspase-8 in bax-, bak-deficient cells
-
Caro-Maldonado A, Tait SW, Ramirez-Peinado S, et al. Glucose deprivation induces an atypical form of apoptosis mediated by caspase-8 in Bax-, Bak-deficient cells. Cell Death Differ 2010; 17:1335-1344.
-
(2010)
Cell Death Differ
, vol.17
, pp. 1335-1344
-
-
Caro-Maldonado, A.1
Tait, S.W.2
Ramirez-Peinado, S.3
-
23
-
-
21044455137
-
Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice
-
DOI 10.1083/jcb.200412022
-
Komatsu M, Waguri S, Ueno T, et al. Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice. The J Cell Biol 2005; 169:425-434. (Pubitemid 40686693)
-
(2005)
Journal of Cell Biology
, vol.169
, Issue.3
, pp. 425-434
-
-
Komatsu, M.1
Waguri, S.2
Ueno, T.3
Iwata, J.4
Murata, S.5
Tanida, I.6
Ezaki, J.7
Mizushima, N.8
Ohsumi, Y.9
Uchiyama, Y.10
Kominami, E.11
Tanaka, K.12
Chiba, T.13
-
24
-
-
41549138483
-
A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy
-
DOI 10.1073/pnas.0712145105
-
Lee IH, Cao L, Mostoslavsky R, et al. A role for the NADdependent deacetylase Sirt1 in the regulation of autophagy. Proc Natl Acad Sci USA 2008; 105:3374-3379. (Pubitemid 351723560)
-
(2008)
Proceedings of the National Academy of Sciences of the United States of America
, vol.105
, Issue.9
, pp. 3374-3379
-
-
In, H.L.1
Cao, L.2
Mostoslavsky, R.3
Lombard, D.B.4
Liu, J.5
Bruns, N.E.6
Tsokos, M.7
Alt, F.W.8
Finkel, T.9
-
25
-
-
67650526046
-
Poly(adpribose) catabolism triggers amp-dependent mitochondrial energy failure
-
Formentini L, Macchiarulo A, Cipriani G, et al. Poly(ADPribose) catabolism triggers AMP-dependent mitochondrial energy failure. J Biol Chem 2009; 284:17668-17676.
-
(2009)
J Biol Chem
, vol.284
, pp. 17668-17676
-
-
Formentini, L.1
Macchiarulo, A.2
Cipriani, G.3
-
26
-
-
34248586036
-
Interaction between atm and parp-1 in response to dna damage and sensitization of atm deficient cells through parp inhibition
-
Aguilar-Quesada R, Munoz-Gamez JA, Martin-Oliva D, et al. Interaction between ATM and PARP-1 in response to DNA damage and sensitization of ATM deficient cells through PARP inhibition. BMC Mol Biol 2007; 8:29.
-
(2007)
BMC Mol Biol
, vol.8
, pp. 29
-
-
Aguilar-Quesada, R.1
Munoz-Gamez, J.A.2
Martin-Oliva, D.3
-
27
-
-
34447548569
-
Ataxia telangiectasia mutated (ATM) signaling network is modulated by a novel poly(ADP-ribose)-dependent pathway in the early response to DNA-damaging agents
-
DOI 10.1074/jbc.M608406200
-
Haince JF, Kozlov S, Dawson VL, et al. Ataxia telangiectasia mutated (ATM) signaling network is modulated by a novel poly(ADP-ribose)-dependent pathway in the early response to DNA-damaging agents. J Biol Chem 2007; 282:16441-16453. (Pubitemid 47100334)
-
(2007)
Journal of Biological Chemistry
, vol.282
, Issue.22
, pp. 16441-16453
-
-
Haince, J.-F.1
Kozlov, S.2
Dawson, V.L.3
Dawson, T.M.4
Hendzel, M.J.5
Lavin, M.F.6
Poirier, G.G.7
-
28
-
-
77955041880
-
Essential regulation of cell bioenergetics by constitutive insp3 receptor ca2+ transfer to mitochondria
-
Cardenas C, Miller RA, Smith I, et al. Essential regulation of cell bioenergetics by constitutive InsP3 receptor Ca2+ transfer to mitochondria. Cell 2010; 142:270-283.
-
(2010)
Cell
, vol.142
, pp. 270-283
-
-
Cardenas, C.1
Miller, R.A.2
Smith, I.3
-
29
-
-
11144245626
-
The role of autophagy during the early neonatal starvation period
-
DOI 10.1038/nature03029
-
Kuma A, Hatano M, Matsui M, et al. The role of autophagy during the early neonatal starvation period. Nature 2004; 432:1032-1036. (Pubitemid 40052234)
-
(2004)
Nature
, vol.432
, Issue.7020
, pp. 1032-1036
-
-
Kuma, A.1
Hatano, M.2
Matsui, M.3
Yamamoto, A.4
Nakaya, H.5
Yoshimori, T.6
Ohsumi, Y.7
Tokuhisa, T.8
Mizushima, N.9
-
30
-
-
0040984333
-
Requirement of poly(ADP-ribose) polymerase in recovery from DNA damage in mice and in cells
-
DOI 10.1073/pnas.94.14.7303
-
de Murcia JM, Niedergang C, Trucco C, et al. Requirement of poly(ADP-ribose) polymerase in recovery from DNA damage in mice and in cells. Proc Natl Acad Sci USA 1997; 94:7303-7307. (Pubitemid 27345310)
-
(1997)
Proceedings of the National Academy of Sciences of the United States of America
, vol.94
, Issue.14
, pp. 7303-7307
-
-
De Murcia, J.M.1
Niedergang, C.2
Trucco, C.3
Ricoul, M.4
Dutrillaux, B.5
Mark, M.6
Oliver, F.J.7
Masson, M.8
Dierich, A.9
Lemeur, M.10
Walztinger, C.11
Chambon, P.12
De Murcia, G.13
-
31
-
-
78649811793
-
Lkb1 regulates cell cycle and energy metabolism in haematopoietic stem cells
-
Nakada D, Saunders TL, Morrison SJ. Lkb1 regulates cell cycle and energy metabolism in haematopoietic stem cells. Nature 2010; 468:653-658.
-
(2010)
Nature
, vol.468
, pp. 653-658
-
-
Nakada, D.1
Saunders, T.L.2
Morrison, S.J.3
-
32
-
-
85028106161
-
Poly(adp-ribose)glycohydrolase is an upstream regulator of ca2+ fluxes in oxidative cell death
-
Blenn C, Wyrsch P, Bader J, Bollhalder M, Althaus FR. Poly(ADP-ribose)glycohydrolase is an upstream regulator of Ca2+ fluxes in oxidative cell death. Cell Mol Life Sci 2011; 68:1455-1466.
-
(2011)
Cell Mol Life Sci
, vol.68
, pp. 1455-1466
-
-
Blenn, C.1
Wyrsch, P.2
Bader, J.3
Bollhalder, M.4
Althaus, F.R.5
-
33
-
-
2642553881
-
Regulation of an ATG7-beclin 1 program of autophaglic cell death by caspase-8
-
DOI 10.1126/science.1096645
-
Yu L, Alva A, Su H, et al. Regulation of an ATG7-beclin 1.program of autophagic cell death by caspase-8. Science 2004; 304:1500-1502. (Pubitemid 38720930)
-
(2004)
Science
, vol.304
, Issue.5676
, pp. 1500-1502
-
-
Yu, L.1
Alva, A.2
Su, H.3
Dutt, P.4
Freundt, E.5
Welsh, S.6
Baehrecke, E.H.7
Lenardo, M.J.8
-
34
-
-
0031822063
-
Peroxynitrite-induced thymocyte apoptosis: The role of caspases and poly (ADP-ribose) synthetase (PARS) activation
-
DOI 10.1046/j.1365-2567.1998.00534.x
-
Virag L, Scott GS, Cuzzocrea S, Marmer D, Salzman AL, Szabo C. Peroxynitrite-induced thymocyte apoptosis: the role of caspases and poly (ADP-ribose) synthetase (PARS) activation. Immunology 1998; 94:345-355. (Pubitemid 28318599)
-
(1998)
Immunology
, vol.94
, Issue.3
, pp. 345-355
-
-
Virag, L.1
Scott, G.S.2
Cuzzocrea, S.3
Marmer, D.4
Salzman, A.L.5
Szabo, C.6
-
35
-
-
34347404887
-
Autophagy mitigates metabolic stress and genome damage in mammary tumorigenesis
-
DOI 10.1101/gad.1565707
-
Karantza-Wadsworth V, Patel S, Kravchuk O, et al. Autophagy mitigates metabolic stress and genome damage in mammary tumorigenesis. Genes Dev 2007; 21:1621-1635. (Pubitemid 47026367)
-
(2007)
Genes and Development
, vol.21
, Issue.13
, pp. 1621-1635
-
-
Karantza-Wadsworth, V.1
Patel, S.2
Kravchuk, O.3
Chen, G.4
Mathew, R.5
Jin, S.6
White, E.7
-
36
-
-
66449099090
-
Autophagy suppresses tumorigenesis through elimination of p62
-
Mathew R, Karp CM, Beaudoin B, et al. Autophagy suppresses tumorigenesis through elimination of p62. Cell 2009; 137:1062-1075.
-
(2009)
Cell
, vol.137
, pp. 1062-1075
-
-
Mathew, R.1
Karp, C.M.2
Beaudoin, B.3
-
37
-
-
64349123107
-
Autophagy mediates the mitotic senescence transition
-
Young AR, Narita M, Ferreira M, et al. Autophagy mediates the mitotic senescence transition. Genes Dev 2009; 23:798-803.
-
(2009)
Genes Dev
, vol.23
, pp. 798-803
-
-
Young, A.R.1
Narita, M.2
Ferreira, M.3
-
38
-
-
76349098949
-
Crosstalk between apoptosis and autophagy within the beclin 1 interactome
-
Maiuri MC, Criollo A, Kroemer G. Crosstalk between apoptosis and autophagy within the Beclin 1 interactome. EMBO J 2010; 29:515-516.
-
(2010)
EMBO J
, vol.29
, pp. 515-516
-
-
Maiuri, M.C.1
Criollo, A.2
Kroemer, G.3
|