The PINK1/Parkin-mediated mitophagy is compromised by PD-associated mutations

Autophagy

Volumn 6, Issue 7, 2010, Pages 871-878

  Geisler, Sven ^a   Holmström, Kira M ^a   Treis, Angela ^a   Skujat, Diana ^a   Weber, Stephanie S ^a   Fiesel, Fabienne C ^a   Kahle, Philipp J ^a   Springer, Wolfdieter ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

Autophagy; Mitochondria; Mitophagy; p62 SQSTM1; Parkin; Parkinson disease; PINK1; Ubiquitin; VDAC1

Indexed keywords

PARKIN; PINK1 ENZYME; PROTEIN SERINE THREONINE KINASE; UNCLASSIFIED DRUG;

ARTICLE; AUTOPHAGY; DEPOLARIZATION; GENE MUTATION; HUMAN; HUMAN CELL; MACROAUTOPHAGY; MITOPHAGY; PARKINSON DISEASE; PROTEIN BINDING; PROTEIN TRANSPORT;

EID: 77957673363     PISSN: 15548627     EISSN: 15548635     Source Type: Journal    
DOI: 10.4161/auto.6.7.13286     Document Type: Article

References (30)

1. Lin MT, Beal MF. Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases. Nature 2006; 443:787-95.
2. Kim Y, Park J, Kim S, Song S, Kwon SK, Lee SH, et al. PINK1 controls mitochondrial localization of Parkin through direct phosphorylation. Biochem Biophys Res Commun 2008; 377:975-80.
3. Narendra D, Tanaka A, Suen DF, Youle RJ. Parkin is recruited selectively to impaired mitochondria and promotes their autophagy. J Cell Biol 2008; 183:795-803.
4. Geisler S, Holmstrom KM, Skujat D, Fiesel FC, Rothfuss OC, Kahle PJ, et al. PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1. Nat Cell Biol 2010; 12:119-31.
5. Kawajiri S, Saiki S, Sato S, Sato F, Hatano T, Eguchi H, et al. PINK1 is recruited to mitochondria with parkin and associates with LC3 in mitophagy. FEBS Lett 2010; 584:1073-9.
6. Matsuda N, Sato S, Shiba K, Okatsu K, Saisho K, Gautier CA, et al. PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy. J Cell Biol 2010; 189:211-21.
7. Narendra DP, Jin SM, Tanaka A, Suen DF, Gautier CA, Shen J, et al. PINK1 is selectively stabilized on impaired mitochondria to activate Parkin. PLoS Biol 2010; 8:1000298.
8. Rakovic A, Grunewald A, Seibler P, Ramirez A, Kock N, Orolicki S, et al. Effect of endogenous mutant and wild-type PINK1 on Parkin in fibroblasts from Parkinson disease patients. Hum Mol Genet 2010; 19:3124-37.
9. Vives-Bauza C, Zhou C, Huang Y, Cui M, de Vries RL, Kim J, et al. PINK1-dependent recruitment of Parkin to mitochondria in mitophagy. Proc Natl Acad Sci USA 2010; 107:378-83.
10. Abou-Sleiman PM, Muqit MM, Wood NW. Expanding insights of mitochondrial dysfunction in Parkinson disease. Nat Rev Neurosci 2006; 7:207-19.
11. Lin W, Kang UJ. Characterization of PINK1 processing, stability and subcellular localization. J Neurochem 2008; 106:464-74.
12. Zhou C, Huang Y, Shao Y, May J, Prou D, Perier C, et al. The kinase domain of mitochondrial PINK1 faces the cytoplasm. Proc Natl Acad Sci USA 2008; 105:12022-7.
13. Clark IE, Dodson MW, Jiang C, Cao JH, Huh JR, Seol JH, et al. Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin. Nature 2006; 441:1162-6.
14. Exner N, Treske B, Paquet D, Holmstrom K, Schiesling C, Gispert S, et al. Loss-of-function of human PINK1 results in mitochondrial pathology and can be rescued by parkin. J Neurosci 2007; 27:12413-8.
15. Park J, Lee SB, Lee S, Kim Y, Song S, Kim S, et al. Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin. Nature 2006; 441:1157-61.
16. Poole AC, Thomas RE, Andrews LA, McBride HM, Whitworth AJ, Pallanck LJ. The PINK1/Parkin pathway regulates mitochondrial morphology. Proc Natl Acad Sci USA 2008; 105:1638-43.
17. Shiba K, Arai T, Sato S, Kubo S, Ohba Y, Mizuno Y, et al. Parkin stabilizes PINK1 through direct interaction. Biochem Biophys Res Commun 2009; 383:331-5.
18. Um JW, Stichel-Gunkel C, Lubbert H, Lee G, Chung KC. Molecular interaction between parkin and PINK1 in mammalian neuronal cells. Mol Cell Neurosci 2009; 40:421-32.
19. Xiong H, Wang D, Chen L, Choo YS, Ma H, Tang C, et al. Parkin, PINK1 and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradation. J Clin Invest 2009; 119:650-60.
20. Sha D, Chin LS, Li L. Phosphorylation of parkin by Parkinson disease-linked kinase PINK1 activates parkin E3 ligase function and NFkappaB signaling. Hum Mol Genet 2010; 19:352-63.
21. Prestel J, Gempel K, Hauser TK, Schweitzer K, Prokisch H, Ahting U, et al. Clinical and molecular characterisation of a Parkinson family with a novel PINK1 mutation. J Neurol 2008; 255:643-8.
22. Hatano Y, Li Y, Sato K, Asakawa S, Yamamura Y, Tomiyama H, et al. Novel PINK1 mutations in early-onset parkinsonism. Ann Neurol 2004; 56:424-7.
23. Valente EM, Abou-Sleiman PM, Caputo V, Muqit MM, Harvey K, Gispert S, et al. Hereditary early-onset Parkinson disease caused by mutations in PINK1. Science 2004; 304:1158-60.
24. Beilina A, Van Der Brug M, Ahmad R, Kesavapany S, Miller DW, Petsko GA, et al. Mutations in PTEN-induced putative kinase 1 associated with recessive parkinsonism have differential effects on protein stability. Proc Natl Acad Sci USA 2005; 102:5703-8.
25. Weihofen A, Ostaszewski B, Minami Y, Selkoe DJ. Pink1 Parkinson mutations, the Cdc37/Hsp90 chaperones and Parkin all influence the maturation or subcellular distribution of Pink1. Hum Mol Genet 2008; 17:602-16.
26. Muqit MM, Abou-Sleiman PM, Saurin AT, Harvey K, Gandhi S, Deas E, et al. Altered cleavage and localization of PINK1 to aggresomes in the presence of proteasomal stress. J Neurochem 2006; 98:156-69.
27. Silvestri L, Caputo V, Bellacchio E, Atorino L, Dallapiccola B, Valente EM, et al. Mitochondrial import and enzymatic activity of PINK1 mutants associated to recessive parkinsonism. Hum Mol Genet 2005; 14:3477-92.
28. Pridgeon JW, Olzmann JA, Chin LS, Li L. PINK1 protects against oxidative stress by phosphorylating mitochondrial chaperone TRAP1. PLoS Biol 2007; 5:172.
29. Dagda RK, Cherra SJ, 3rd, Kulich SM, Tandon A, Park D, Chu CT. Loss of PINK1 function promotes mitophagy through effects on oxidative stress and mitochondrial fission. J Biol Chem 2009; 284:13843-55.
30. Rasband WS. ImageJ. US National Institute of Health, Bethesda, Maryland, USA 2006.