Mechanisms of dealing with DNA damage in terminally differentiated cells

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 685, Issue 1-2, 2010, Pages 38-44

  Fortini, P ^a   Dogliotti, E ^a  

^a ISTITUTO SUPERIORE DI SANITÀ   (Italy)

Author keywords

Apoptosis; Autophagy; Cell differentiation; DNA damage signalling; DNA repair

Indexed keywords

CHECKPOINT KINASE 1; PROTEIN P53;

APOPTOSIS; AUTOPHAGY; CELL CYCLE; CELL DEATH; CELL DIFFERENTIATION; CELL FUNCTION; CELL PROLIFERATION; CELL PROTECTION; DNA DAMAGE; DNA REPAIR; EXCISION REPAIR; HOMOLOGOUS RECOMBINATION; MISMATCH REPAIR; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; REVIEW;

ANIMALS; APOPTOSIS; AUTOPHAGY; CELL DIFFERENTIATION; DNA DAMAGE; DNA REPAIR; HUMANS; SIGNAL TRANSDUCTION;

EID: 75749157306     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mrfmmm.2009.11.003     Document Type: Review

References (57)

1. Tichy E.D., and Stambrook P.J. DNA repair in murine embryonic stem cells and differentiated cells. Exp. Cell. Res. 314 (2008) 1929-1936
2. Nouspikel T. DNA repair in differentiated cells: some new answers to old questions. Neuroscience 145 (2007) 1213-1221
3. Nouspikel T. DNA repair in mammalian cells: so DNA repair really is that important?. Cell. Mol. Life Sci. 66 (2009) 965-967
4. Nouspikel T., and Hanawalt P.C. Impaired nucleotide excision repair upon macrophage differentiation is corrected by E1 ubiquitin-activating enzyme. Proc. Natl. Acad. Sci. U.S.A. 103 (2006) 16188-16193
5. Nouspikel T., and Hanawalt P.C. Terminally differentiated human neurons repair transcribed genes but display attenuated global DNA repair and modulation of repair gene expression. Mol. Cell. Biol. 20 (2000) 1562-1570
6. Bielas J.H. Non-transcribed strand repair revealed in quiescent cells. Mutagenesis 21 (2006) 49-53
7. Nouspikel T.P., Hyka-Nouspikel N., and Hanawalt P.C. Transcription domain-associated repair in human cells. Mol. Cell. Biol. 26 (2006) 8722-8730
8. Hsu P.H., Hanawalt P.C., and Nouspikel T. Nucleotide excision repair phenotype of human acute myeloid leukemia cell lines at various stages of differentiation. Mutat. Res. 614 (2007) 3-15
9. Backendorf C., de Wit J., van Oosten M., Stout G.J., Mitchell J.R., Borgstein A.M., van der Horst G.T., de Gruijl F.R., Brouwer J., Mullenders L.H., and Hoeijmakers J.H. Repair characteristics and differentiation propensity of long-term cultures of epidermal keratinocytes derived from normal and NER-deficient mice. DNA Repair (Amst.) 4 (2005) 1325-1336
10. Oh D.H., and Yeh K. Differentiating human keratinocytes are deficient in p53 but retain global nucleotide excision repair following ultraviolet radiation. DNA Repair (Amst.) 4 (2005) 1149-1159
11. Fortini P., and Dogliotti E. Base damage and single-strand break repair: mechanisms and functional significance of short- and long-patch repair subpathways. DNA Repair (Amst.) 6 (2007) 398-409
12. Boonstra J., and Post J.A. Molecular events associated with reactive oxygen species and cell cycle progression in mammalian cells. Gene 337 (2004) 1-13
13. Narciso L., Fortini P., Pajalunga D., Franchitto A., Liu P., Degan P., Frechet M., Demple B., Crescenzi M., and Dogliotti E. Terminally differentiated muscle cells are defective in base excision DNA repair and hypersensitive to oxygen injury. Proc. Natl. Acad. Sci. U.S.A. 104 (2007) 17010-17015
14. Owusu-Ansah E., and Banerjee U. Reactive oxygen species prime Drosophila haematopoietic progenitors for differentiation. Nature 461 (2009) 537-541
15. Tan Y., Raychaudhuri P., and Costa R.H. Chk2 mediates stabilization of the FoxM1 transcription factor to stimulate expression of DNA repair genes. Mol. Cell. Biol. 27 (2007) 1007-1016
16. Chen D., Yu Z., Zhu Z., and Lopez C.D. E2F1 regulates the base excision repair gene XRCC1 and promotes DNA repair. J. Biol. Chem. 283 (2008) 15381-15389
17. Kulkarni A., McNeill D.R., Gleichmann M., Mattson M.P., and Wilson III D.M. XRCC1 protects against the lethality of induced oxidative DNA damage in nondividing neural cells. Nucleic Acids Res. 36 (2008) 5111-5121
18. Hildrestrand G.A., Diep D.B., Kunke D., Bolstad N., Bjoras M., Krauss S., and Luna L. The capacity to remove 8-oxoG is enhanced in newborn neural stem/progenitor cells and decreases in juvenile mice and upon cell differentiation. DNA Repair (Amst.) 6 (2007) 723-732
19. Sung J.S., DeMott M.S., and Demple B. Long-patch base excision DNA repair of 2-deoxyribonolactone prevents the formation of DNA-protein cross-links with DNA polymerase beta. J. Biol. Chem. 280 (2005) 39095-39103
20. Liu P., Qian L., Sung J.S., de Souza-Pinto N.C., Zheng L., Bogenhagen D.F., Bohr V.A., Wilson III D.M., Shen B., and Demple B. Removal of oxidative DNA damage via FEN1-dependent long-patch base excision repair in human cell mitochondria. Mol. Cell. Biol. 28 (2008) 4975-4987
21. Szczesny B., Tann A.W., Longley M.J., Copeland W.C., and Mitra S. Long patch base excision repair in mammalian mitochondrial genomes. J. Biol. Chem. 283 (2008) 26349-26356
22. Francisconi S., Codenotti M., Ferrari-Toninelli G., Uberti D., and Memo M. Preservation of DNA integrity and neuronal degeneration. Brain Res. Brain Res. Rev. 48 (2005) 347-351
23. Belloni M., Uberti D., Rizzini C., Jiricny J., and Memo M. Induction of two DNA mismatch repair proteins, MSH2 and MSH6, in differentiated human neuroblastoma SH-SY5Y cells exposed to doxorubicin. J. Neurochem. 72 (1999) 974-979
24. David P., Efrati E., Tocco G., Krauss S.W., and Goodman M.F. DNA replication and postreplication mismatch repair in cell-free extracts from cultured human neuroblastoma and fibroblast cells. J. Neurosci. 17 (1997) 8711-8720
25. Panigrahi G.B., Lau R., Montgomery S.E., Leonard M.R., and Pearson C.E. Slipped (CTG)*(CAG) repeats can be correctly repaired, escape repair or undergo error-prone repair. Nat. Struct. Mol. Biol. 12 (2005) 654-662
26. Bernstein K.A., and Rothstein R. At loose ends: resecting a double-strand break. Cell 137 (2009) 807-810
27. Orii K.E., Lee Y., Kondo N., and McKinnon P.J. Selective utilization of nonhomologous end-joining and homologous recombination DNA repair pathways during nervous system development. Proc. Natl. Acad. Sci. U.S.A. 103 (2006) 10017-10022
28. Meulle A., Salles B., Daviaud D., Valet P., and Muller C. Positive regulation of DNA double strand break repair activity during differentiation of long life span cells: the example of adipogenesis. PLoS One 3 (2008) e3345
29. Sordet O., Redon C.E., Guirouilh-Barbat J., Smith S., Solier S., Douarre C., Conti C., Nakamura A.J., Das B.B., Nicolas E., Kohn K.W., Bonner W.M., and Pommier Y. Ataxia telangiectasia mutated activation by transcription- and topoisomerase I-induced DNA double-strand breaks. EMBO Rep. 10 (2009) 887-893
30. Wallingford J.B., Seufert D.W., Virta V.C., and Vize P.D. p53 activity is essential for normal development in Xenopus. Curr. Biol. 7 (1997) 747-757
31. Donehower L.A., Harvey M., Slagle B.L., McArthur M.J., Montgomery Jr. C.A., Butel J.S., and Bradley A. Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours. Nature 356 (1992) 215-221
32. Pozniak C.D., Barnabe-Heider F., Rymar V.V., Lee A.F., Sadikot A.F., and Miller F.D. p73 is required for survival and maintenance of CNS neurons. J. Neurosci. 22 (2002) 9800-9809
33. Belloni L., Moretti F., Merlo P., Damalas A., Costanzo A., Blandino G., and Levrero M. DNp73alpha protects myogenic cells from apoptosis. Oncogene 25 (2006) 3606-3612
34. Porrello A., Cerone M.A., Coen S., Gurtner A., Fontemaggi G., Cimino L., Piaggio G., Sacchi A., and Soddu S. p53 regulates myogenesis by triggering the differentiation activity of pRb. J. Cell Biol. 151 (2000) 1295-1304
35. Cam H., Griesmann H., Beitzinger M., Hofmann L., Beinoraviciute-Kellner R., Sauer M., Huttinger-Kirchhof N., Oswald C., Friedl P., Gattenlohner S., Burek C., Rosenwald A., and Stiewe T. p53 family members in myogenic differentiation and rhabdomyosarcoma development. Cancer Cell 10 (2006) 281-293
36. Tedeschi A., and Di Giovanni S. The non-apoptotic role of p53 in neuronal biology: enlightening the dark side of the moon. EMBO Rep. 10 (2009) 576-583
37. Bartek J., and Lukas J. Chk1 and Chk2 kinases in checkpoint control and cancer. Cancer Cell 3 (2003) 421-429
38. Jones G.G., Reaper P.M., Pettitt A.R., and Sherrington P.D. The ATR-p53 pathway is suppressed in noncycling normal and malignant lymphocytes. Oncogene 23 (2004) 1911-1921
39. Camarda G., Siepi F., Pajalunga D., Bernardini C., Rossi R., Montecucco A., Meccia E., and Crescenzi M. A pRb-independent mechanism preserves the postmitotic state in terminally differentiated skeletal muscle cells. J. Cell Biol. 167 (2004) 417-423
40. Latella L., Lukas J., Simone C., Puri P.L., and Bartek J. Differentiation-induced radioresistance in muscle cells. Mol. Cell. Biol. 24 (2004) 6350-6361
41. Lukas C., Bartkova J., Latella L., Falck J., Mailand N., Schroeder T., Sehested M., Lukas J., and Bartek J. DNA damage-activated kinase Chk2 is independent of proliferation or differentiation yet correlates with tissue biology. Cancer Res. 61 (2001) 4990-4993
42. Puri P.L., Bhakta K., Wood L.D., Costanzo A., Zhu J., and Wang J.Y. A myogenic differentiation checkpoint activated by genotoxic stress. Nat. Genet. 32 (2002) 585-593
43. Simonatto M., Latella L., and Puri P.L. DNA damage and cellular differentiation: more questions than responses. J. Cell. Physiol. 213 (2007) 642-648
44. Kruman II. Why do neurons enter the cell cycle?. Cell Cycle 3 (2004) 769-773
45. Wang X. The expanding role of mitochondria in apoptosis. Genes Dev. 15 (2001) 2922-2933
46. Miller F.D., Pozniak C.D., and Walsh G.S. Neuronal life and death: an essential role for the p53 family. Cell Death Differ. 7 (2000) 880-888
47. Schuler M., and Green D.R. Transcription, apoptosis and p53: catch-22. Trends Genet. 21 (2005) 182-187
48. Vaughn A.E., and Deshmukh M. Essential postmitochondrial function of p53 uncovered in DNA damage-induced apoptosis in neurons. Cell Death Differ. 14 (2007) 973-981
49. Smith M.I., Huang Y.Y., and Deshmukh M. Skeletal muscle differentiation evokes endogenous XIAP to restrict the apoptotic pathway. PLoS One 4 (2009) e5097
50. Mizushima N., Levine B., Cuervo A.M., and Klionsky D.J. Autophagy fights disease through cellular self-digestion. Nature 451 (2008) 1069-1075
51. Martinez-Vicente M., and Cuervo A.M. Autophagy and neurodegeneration: when the cleaning crew goes on strike. Lancet Neurol. 6 (2007) 352-361
52. Mammucari C., Milan G., Romanello V., Masiero E., Rudolf R., Del Piccolo P., Burden S.J., Di Lisi R., Sandri C., Zhao J., Goldberg A.L., Schiaffino S., and Sandri M. FoxO3 controls autophagy in skeletal muscle in vivo. Cell Metab. 6 (2007) 458-471
53. Noda T., Fujita N., and Yoshimori T. The late stages of autophagy: how does the end begin?. Cell Death Differ. 16 (2009) 984-990
54. Levine B., and Abrams J. p53: the Janus of autophagy?. Nat. Cell Biol. 10 (2008) 637-639
55. Tasdemir E., Maiuri M.C., Galluzzi L., Vitale I., Djavaheri-Mergny M., D'Amelio M., Criollo A., Morselli E., Zhu C., Harper F., Nannmark U., Samara C., Pinton P., Vicencio J.M., Carnuccio R., Moll U.M., Madeo F., Paterlini-Brechot P., Rizzuto R., Szabadkai G., Pierron G., Blomgren K., Tavernarakis N., Codogno P., Cecconi F., and Kroemer G. Regulation of autophagy by cytoplasmic p53. Nat. Cell Biol. 10 (2008) 676-687
56. Schmid P., Lorenz A., Hameister H., and Montenarh M. Expression of p53 during mouse embryogenesis. Development 113 (1991) 857-865
57. Meijer A.J., and Codogno P. Autophagy: regulation and role in disease. Crit. Rev. Clin. Lab. Sci. 46 (2009) 210-240