Sensitization to radiation-induced DNA damage accelerates loss of bcl-2 and increases apoptosis and autophagy

Cancer Biology and Therapy

Volumn 7, Issue 10, 2008, Pages 1561-1566

  Rieber, Manuel ^a,b   Rieber, Mary Strasberg ^a  

^a Instituto Venezolano de Investigaciones Cientificas Centro de Microbiologia y Biologia Celular   (Venezuela)

^b INSTITUTO VENEZOLANO DE INVESTIGACIONES CIENTÍFICAS   (Venezuela)

Author keywords

Apoptosis; Autophagy; Bax bcl 2 ratio; PARP cleavage; Radiation sensitizer

Indexed keywords

BROXURIDINE; CYCLIN A; DNA; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BAX; PROTEIN BCL 2; RETINOBLASTOMA PROTEIN;

APOPTOSIS; ARTICLE; AUTOPHAGY; CELL CYCLE REGULATION; CELL NUCLEUS; CELL VACUOLE; CHEMOLUMINESCENCE; CONTROLLED STUDY; CYTOPLASM; DNA DAMAGE; DOWN REGULATION; GENOTOXICITY; HUMAN; HUMAN CELL; IMMUNOBLOTTING; MELANOMA CELL; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; RADIATION DOSE; RADIOSENSITIZATION; ULTRAVIOLET RADIATION;

EID: 54349115389     PISSN: 15384047     EISSN: 15558576     Source Type: Journal    
DOI: 10.4161/cbt.7.10.6540     Document Type: Article

References (22)

1. Dewey WC, Humphrey RM. Increase in radiosensitivity to ionizing radiation related to replacement of thymidine in mammalian cells with 5-bromodeoxyuridine. Radiat Res 1965; 26:538-53.
2. Cecchini S, Girouard S, Huels MA, Sanche L, Hunting DJ. Single-strand-specific radiosensitization of DNA by bromodeoxyuridine. Radiat Res 2004; 162:604-15.
3. Taverna P, Hwang HS, Schupp JE, et al. Inhibition of base excision repair potentiates iododeoxyuridine-induced cytotoxicity and radiosensitization. Cancer Res 2003; 63:838-46.
4. Turner DP, Cortellino S, Schupp JE, Caretti E, Loh T, Kinsella TJ, Bellacosa A. The DNA N-glycosylase MED1 exhibits preference for halogenated pyrimidines and is involved in the cytotoxicity of 5-iododeoxyuridine.Cancer Res 2006; 66:7686-93.
5. 1/S Cyclin-dependent Kinases. J Biol Chem 1997; 272:12738-46.
6. Dou QP, Lui VW. Failure to dephosphorylate retinoblastoma protein in drug-resistant cells. Cancer Res 1995; 55:5222-5.
7. 1/S cell cycle checkpoint 2004; 23:4068-75.
8. Whittaker SR, Walton MI, Garrett MD, Workman P. The Cyclin-dependent kinase inhibitor CYC202 (R-roscovitine) inhibits retinoblastoma protein phosphorylation, causes loss of Cyclin D1, and activates the mitogen-activated protein kinase pathway. Cancer Res 2004; 64:262-72.
9. Harbour JW and Dean DC. Rb function in cell cycle regulation and apoptosis. Nat Cell Biol 2000; 2:65-67.
10. Macleod KF, Hu Y, Jacks T. Loss of Rb activates both p53-dependent and independent cell death pathways in the developing mouse nervous system. EMBO J 1996; 15:6178-88.
11. Oltvai ZN, Milliman CL, Korsmeyer SJ. Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell 1993; 74:609-19.
12. Rieber MS and Rieber M. UV radiation induces DNA fragmentation and cell death in B16 melanoma sensitized by bromodeoxyuridine: impaired c-jun induction and defective tyrosine phosphorylation signalling.Biochem Biophys Res Commun 1994; 203:1629-37.
13. Rieber M and Strasberg Rieber M. N-Acetylcysteine enhances UV-mediated caspase-3 activation, fragmentation of E2F-4, and apoptosis in human C8161 melanoma: inhibition by ectopic Bcl-2 expression. Biochem Pharmacol 2003; 65:1593-601.
14. Solorzano L, Strasberg Rieber M and Rieber M. Cancer Res. Lower cyclin H and cyclin-dependent kinase-activating kinase activity in cell cycle arrest induced by lack of adhesion to substratum 2000; 60:7114-8.
15. Soldani C and Scovassi AI. Poly(ADP-ribose) polymerase-1 cleavage during apoptosis: an update. Apoptosis 2002; 7:321-8.
16. Maiuri MC, Criollo A, Tasdemir E, Vicencio JM, Tajeddine N, Hickman JA, Geneste O, Kroemer G. BH3-only proteins and BH3 mimetics induce autophagy by competitively disrupting the interaction between Beclin 1 and Bcl-2/Bcl-X(L). Autophagy 2007; 3:374-6.
17. Yokoyama T, Miyazawa K, Naito M, Toyotake J, Tauchi T, Itoh M, Yuo A, Hayashi Y, Georgescu MM, Kondo Y, Kondo S, Ohyashiki K. Vitamin K2 induces autophagy and apoptosis simultaneously in leukemia cells. Autophagy 2008; 4:in press.
18. Rieber M, Strasberg Rieber M. Tumor hypersensitive DNA is enriched in c-myc sequences and reacts differentially with normal and malignant genomic DNA. Biochem Biophys Res Commun 1990; 169:352-9.
19. Hsieh JK, Yap D, O'Connor DJ, Fogal V, Fallis L, Chan F, Zhong S, Lu X. Novel Function of the Cyclin A Binding Site of E2F in Regulating p53-Induced Apoptosis in Response to DNA Damage. Mol Cell Biol 2002; 22:78-93.
20. Wiedenmann N, Koto M, Raju U, Milas L, Mason KA. Modulation of tumor radiation response with G3139, a bcl-2 antisense oligonucleotide. Invest New Drugs 2007; 25:411-6.
21. Mu Z, Hachem P, Pollack A. Antisense Bcl-2 sensitizes prostate cancer cells to radiation. Prostate 2001; 65:331-40.
22. Rieber M, Strasberg-Rieber M. Different chromatin organization in benign and malignant cells revealed by unequal nuclease sensitivity between tumor and normal cell genomes. Am J Pathol 2007; 170:787-8.