메뉴 건너뛰기




Volumn 165, Issue 1, 2015, Pages 221-240

Epigenetic enzymes are the therapeutic targets for CD4+CD25+/highFoxp3+ regulatory T cells

Author keywords

[No Author keywords available]

Indexed keywords

ALDESLEUKIN; CD4 ANTIGEN; DNA METHYLTRANSFERASE INHIBITOR; ENTINOSTAT; HISTONE ACETYLTRANSFERASE; HISTONE DEACETYLASE; HISTONE DEACETYLASE INHIBITOR; INTERLEUKIN 2 RECEPTOR ALPHA; MICRORNA 155; TRANSCRIPTION FACTOR FOXP3; UNTRANSLATED RNA; VORINOSTAT; FORKHEAD TRANSCRIPTION FACTOR; FOXP3 PROTEIN, HUMAN; HISTONE; IL2RA PROTEIN, HUMAN;

EID: 84919686339     PISSN: 19315244     EISSN: 18781810     Source Type: Journal    
DOI: 10.1016/j.trsl.2014.08.001     Document Type: Review
Times cited : (33)

References (191)
  • 1
    • 33744996730 scopus 로고    scopus 로고
    • Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in self-tolerance and autoimmune disease
    • S. Sakaguchi, R. Setoguchi, H. Yagi, and T. Nomura Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in self-tolerance and autoimmune disease Curr Top Microbiol Immunol 305 2006 51 66
    • (2006) Curr Top Microbiol Immunol , vol.305 , pp. 51-66
    • Sakaguchi, S.1    Setoguchi, R.2    Yagi, H.3    Nomura, T.4
  • 2
    • 84857193362 scopus 로고    scopus 로고
    • The composition and signaling of the IL-35 receptor are unconventional
    • L.W. Collison, G.M. Delgoffe, and C.S. Guy The composition and signaling of the IL-35 receptor are unconventional Nat Immunol 13 2012 290 299
    • (2012) Nat Immunol , vol.13 , pp. 290-299
    • Collison, L.W.1    Delgoffe, G.M.2    Guy, C.S.3
  • 3
    • 84863376362 scopus 로고    scopus 로고
    • IL-35 is a novel responsive anti-inflammatory cytokine - A new system of categorizing anti-inflammatory cytokines
    • X. Li, J. Mai, and A. Virtue IL-35 is a novel responsive anti-inflammatory cytokine - a new system of categorizing anti-inflammatory cytokines PLoS One 7 2012 e33628
    • (2012) PLoS One , vol.7 , pp. 33628
    • Li, X.1    Mai, J.2    Virtue, A.3
  • 4
    • 84875936395 scopus 로고    scopus 로고
    • FOXP3: Genetic and epigenetic implications for autoimmunity
    • H. Katoh, P. Zheng, and Y. Liu FOXP3: genetic and epigenetic implications for autoimmunity J Autoimmun 41 2013 72 78
    • (2013) J Autoimmun , vol.41 , pp. 72-78
    • Katoh, H.1    Zheng, P.2    Liu, Y.3
  • 5
    • 59849085588 scopus 로고    scopus 로고
    • Epigenetic regulation of Foxp3 expression in regulatory T cells by DNA methylation
    • G. Lal, N. Zhang, and W. van der Touw Epigenetic regulation of Foxp3 expression in regulatory T cells by DNA methylation J Immunol 182 2009 259 273
    • (2009) J Immunol , vol.182 , pp. 259-273
    • Lal, G.1    Zhang, N.2    Van Der Touw, W.3
  • 6
    • 77954515736 scopus 로고    scopus 로고
    • The FOX transcription factors regulate vascular pathology, diabetes and Tregs
    • X.F. Yang, P. Fang, and S. Meng The FOX transcription factors regulate vascular pathology, diabetes and Tregs Front Biosci (Schol Ed) 1 2009 420 436
    • (2009) Front Biosci (Schol Ed) , vol.1 , pp. 420-436
    • Yang, X.F.1    Fang, P.2    Meng, S.3
  • 7
    • 84861451140 scopus 로고    scopus 로고
    • Loss of epigenetic modification driven by the Foxp3 transcription factor leads to regulatory T cell insufficiency
    • M.L. Bettini, F. Pan, and M. Bettini Loss of epigenetic modification driven by the Foxp3 transcription factor leads to regulatory T cell insufficiency Immunity 36 2012 717 730
    • (2012) Immunity , vol.36 , pp. 717-730
    • Bettini, M.L.1    Pan, F.2    Bettini, M.3
  • 9
    • 0347785480 scopus 로고    scopus 로고
    • Control of regulatory T cell development by the transcription factor Foxp3
    • S. Hori, T. Nomura, and S. Sakaguchi Control of regulatory T cell development by the transcription factor Foxp3 Science 299 2003 1057 1061
    • (2003) Science , vol.299 , pp. 1057-1061
    • Hori, S.1    Nomura, T.2    Sakaguchi, S.3
  • 10
    • 0037385330 scopus 로고    scopus 로고
    • Foxp3 programs the development and function of CD4+CD25+ regulatory T cells
    • J.D. Fontenot, M.A. Gavin, and A.Y. Rudensky Foxp3 programs the development and function of CD4+CD25+ regulatory T cells Nat Immunol 4 2003 330 336
    • (2003) Nat Immunol , vol.4 , pp. 330-336
    • Fontenot, J.D.1    Gavin, M.A.2    Rudensky, A.Y.3
  • 11
    • 84873620273 scopus 로고    scopus 로고
    • Helper T-cell identity and evolution of differential transcriptomes and epigenomes
    • G. Vahedi, A.C. Poholek, and T.W. Hand Helper T-cell identity and evolution of differential transcriptomes and epigenomes Immunol Rev 252 2013 24 40
    • (2013) Immunol Rev , vol.252 , pp. 24-40
    • Vahedi, G.1    Poholek, A.C.2    Hand, T.W.3
  • 12
    • 70449717294 scopus 로고    scopus 로고
    • Epigenetic mechanisms of regulation of Foxp3 expression
    • G. Lal, and J.S. Bromberg Epigenetic mechanisms of regulation of Foxp3 expression Blood 114 2009 3727 3735
    • (2009) Blood , vol.114 , pp. 3727-3735
    • Lal, G.1    Bromberg, J.S.2
  • 13
    • 52049107810 scopus 로고    scopus 로고
    • Higher expression of Bax in regulatory T cells increases vascular inflammation
    • Z. Xiong, J. Song, and Y. Yan Higher expression of Bax in regulatory T cells increases vascular inflammation Front Biosci 13 2008 7143 7155
    • (2008) Front Biosci , vol.13 , pp. 7143-7155
    • Xiong, Z.1    Song, J.2    Yan, Y.3
  • 14
    • 62649114466 scopus 로고    scopus 로고
    • Expression of TCTP antisense in CD25(high) regulatory T cells aggravates cuff-injured vascular inflammation
    • Z. Xiong, Y. Yan, and J. Song Expression of TCTP antisense in CD25(high) regulatory T cells aggravates cuff-injured vascular inflammation Atherosclerosis 203 2009 401 408
    • (2009) Atherosclerosis , vol.203 , pp. 401-408
    • Xiong, Z.1    Yan, Y.2    Song, J.3
  • 15
    • 59849108157 scopus 로고    scopus 로고
    • CD25high T cells with a prolonged survival inhibit development of diabetes
    • Y. Yan, Z. Xiong, and S. Zhang CD25high T cells with a prolonged survival inhibit development of diabetes Int J Immunopathol Pharmacol 21 2008 767 780
    • (2008) Int J Immunopathol Pharmacol , vol.21 , pp. 767-780
    • Yan, Y.1    Xiong, Z.2    Zhang, S.3
  • 16
    • 77956645431 scopus 로고    scopus 로고
    • Th 17 cells interplay with Foxp3+ Tregs in regulation of inflammation and autoimmunity
    • J. Mai, H. Wang, and X.F. Yang Th 17 cells interplay with Foxp3+ Tregs in regulation of inflammation and autoimmunity Front Biosci (Landmark Ed) 15 2010 986 1006
    • (2010) Front Biosci (Landmark Ed) , vol.15 , pp. 986-1006
    • Mai, J.1    Wang, H.2    Yang, X.F.3
  • 17
    • 38449093587 scopus 로고    scopus 로고
    • Factors regulating apoptosis and homeostasis of CD4+ CD25(high) FOXP3+ regulatory T cells are new therapeutic targets
    • X.F. Yang Factors regulating apoptosis and homeostasis of CD4+ CD25(high) FOXP3+ regulatory T cells are new therapeutic targets Front Biosci 13 2008 1472 1499
    • (2008) Front Biosci , vol.13 , pp. 1472-1499
    • Yang, X.F.1
  • 18
    • 77952500002 scopus 로고    scopus 로고
    • The forkhead transcription factors play important roles in vascular pathology and immunology
    • X.F. Yang, P. Fang, and S. Meng The forkhead transcription factors play important roles in vascular pathology and immunology Adv Exp Med Biol 665 2009 90 105
    • (2009) Adv Exp Med Biol , vol.665 , pp. 90-105
    • Yang, X.F.1    Fang, P.2    Meng, S.3
  • 20
    • 0014792798 scopus 로고
    • Cell interactions in the induction of tolerance: The role of thymic lymphocytes
    • R.K. Gershon, and K. Kondo Cell interactions in the induction of tolerance: the role of thymic lymphocytes Immunology 18 1970 723 737
    • (1970) Immunology , vol.18 , pp. 723-737
    • Gershon, R.K.1    Kondo, K.2
  • 21
    • 0029150110 scopus 로고
    • Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases
    • S. Sakaguchi, N. Sakaguchi, M. Asano, M. Itoh, and M. Toda Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases J Immunol 155 1995 1151 1164
    • (1995) J Immunol , vol.155 , pp. 1151-1164
    • Sakaguchi, S.1    Sakaguchi, N.2    Asano, M.3    Itoh, M.4    Toda, M.5
  • 22
    • 0035167967 scopus 로고    scopus 로고
    • The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3
    • C.L. Bennett, J. Christie, and F. Ramsdell The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3 Nat Genet 27 2001 20 21
    • (2001) Nat Genet , vol.27 , pp. 20-21
    • Bennett, C.L.1    Christie, J.2    Ramsdell, F.3
  • 23
    • 77956475716 scopus 로고    scopus 로고
    • Increased CD127 expression on activated FOXP3+ CD4+ regulatory T cells
    • F. Simonetta, A. Chiali, and C. Cordier Increased CD127 expression on activated FOXP3+ CD4+ regulatory T cells Eur J Immunol 40 2010 2528 2538
    • (2010) Eur J Immunol , vol.40 , pp. 2528-2538
    • Simonetta, F.1    Chiali, A.2    Cordier, C.3
  • 24
    • 78149419897 scopus 로고    scopus 로고
    • T regulatory cells in cord blood - FOXP3 demethylation as reliable quantitative marker
    • J. Liu, A. Lluis, and S. Illi T regulatory cells in cord blood - FOXP3 demethylation as reliable quantitative marker PLoS One 5 2010 e13267
    • (2010) PLoS One , vol.5 , pp. 13267
    • Liu, J.1    Lluis, A.2    Illi, S.3
  • 25
    • 84862833645 scopus 로고    scopus 로고
    • Pygo2 associates with MLL2 histone methyltransferase and GCN5 histone acetyltransferase complexes to augment Wnt target gene expression and breast cancer stem-like cell expansion
    • J. Chen, Q. Luo, and Y. Yuan Pygo2 associates with MLL2 histone methyltransferase and GCN5 histone acetyltransferase complexes to augment Wnt target gene expression and breast cancer stem-like cell expansion Mol Cell Biol 30 2010 5621 5635
    • (2010) Mol Cell Biol , vol.30 , pp. 5621-5635
    • Chen, J.1    Luo, Q.2    Yuan, Y.3
  • 26
    • 58349116249 scopus 로고    scopus 로고
    • Quantitative DNA methylation analysis of FOXP3 as a new method for counting regulatory T cells in peripheral blood and solid tissue
    • G. Wieczorek, A. Asemissen, and F. Model Quantitative DNA methylation analysis of FOXP3 as a new method for counting regulatory T cells in peripheral blood and solid tissue Cancer Res 69 2009 599 608
    • (2009) Cancer Res , vol.69 , pp. 599-608
    • Wieczorek, G.1    Asemissen, A.2    Model, F.3
  • 27
    • 84883746004 scopus 로고    scopus 로고
    • Molecular determinants of regulatory T cell development: The essential roles of epigenetic changes
    • Y. Kitagawa, N. Ohkura, and S. Sakaguchi Molecular determinants of regulatory T cell development: the essential roles of epigenetic changes Front Immunol 4 2013 106
    • (2013) Front Immunol , vol.4 , pp. 106
    • Kitagawa, Y.1    Ohkura, N.2    Sakaguchi, S.3
  • 28
    • 43949105866 scopus 로고    scopus 로고
    • Regulatory T cells and immune tolerance
    • S. Sakaguchi, T. Yamaguchi, T. Nomura, and M. Ono Regulatory T cells and immune tolerance Cell 133 2008 775 787
    • (2008) Cell , vol.133 , pp. 775-787
    • Sakaguchi, S.1    Yamaguchi, T.2    Nomura, T.3    Ono, M.4
  • 29
    • 80155214095 scopus 로고    scopus 로고
    • Cellular immunity, low-density lipoprotein and atherosclerosis: Break of tolerance in the artery wall
    • D.F. Ketelhuth, and G.K. Hansson Cellular immunity, low-density lipoprotein and atherosclerosis: break of tolerance in the artery wall Thromb Haemost 106 2011 779 786
    • (2011) Thromb Haemost , vol.106 , pp. 779-786
    • Ketelhuth, D.F.1    Hansson, G.K.2
  • 30
    • 34547222902 scopus 로고    scopus 로고
    • Molecular mechanisms of CD4+ T-cell anergy
    • C.G. Fathman, and N.B. Lineberry Molecular mechanisms of CD4+ T-cell anergy Nat Rev Immunol 7 2007 599 609
    • (2007) Nat Rev Immunol , vol.7 , pp. 599-609
    • Fathman, C.G.1    Lineberry, N.B.2
  • 31
    • 33746342994 scopus 로고    scopus 로고
    • Foxp3+ CD25+ CD4+ natural regulatory T cells in dominant self-tolerance and autoimmune disease
    • S. Sakaguchi, M. Ono, and R. Setoguchi Foxp3+ CD25+ CD4+ natural regulatory T cells in dominant self-tolerance and autoimmune disease Immunol Rev 212 2006 8 27
    • (2006) Immunol Rev , vol.212 , pp. 8-27
    • Sakaguchi, S.1    Ono, M.2    Setoguchi, R.3
  • 32
    • 34548680982 scopus 로고    scopus 로고
    • Foxp3+ regulatory T cells: Selfishness under scrutiny
    • G.L. Stephens, and E.M. Shevach Foxp3+ regulatory T cells: selfishness under scrutiny Immunity 27 2007 417 419
    • (2007) Immunity , vol.27 , pp. 417-419
    • Stephens, G.L.1    Shevach, E.M.2
  • 33
    • 0036096843 scopus 로고    scopus 로고
    • A neuronal receptor, neuropilin-1, is essential for the initiation of the primary immune response
    • R. Tordjman, Y. Lepelletier, and V. Lemarchandel A neuronal receptor, neuropilin-1, is essential for the initiation of the primary immune response Nat Immunol 3 2002 477 482
    • (2002) Nat Immunol , vol.3 , pp. 477-482
    • Tordjman, R.1    Lepelletier, Y.2    Lemarchandel, V.3
  • 34
    • 84867901322 scopus 로고    scopus 로고
    • Neuropilin-1 distinguishes natural and inducible regulatory T cells among regulatory T cell subsets in vivo
    • S1-S19
    • M. Yadav, C. Louvet, and D. Davini Neuropilin-1 distinguishes natural and inducible regulatory T cells among regulatory T cell subsets in vivo J Exp Med 209 2012 1713 1722 S1-S19
    • (2012) J Exp Med , vol.209 , pp. 1713-1722
    • Yadav, M.1    Louvet, C.2    Davini, D.3
  • 35
    • 84867899425 scopus 로고    scopus 로고
    • Neuropilin 1 is expressed on thymus-derived natural regulatory T cells, but not mucosa-generated induced Foxp3+ T reg cells
    • S1
    • J.M. Weiss, A.M. Bilate, and M. Gobert Neuropilin 1 is expressed on thymus-derived natural regulatory T cells, but not mucosa-generated induced Foxp3+ T reg cells J Exp Med 209 2012 1723 1742 S1
    • (2012) J Exp Med , vol.209 , pp. 1723-1742
    • Weiss, J.M.1    Bilate, A.M.2    Gobert, M.3
  • 36
    • 2442484053 scopus 로고    scopus 로고
    • Naturally arising CD4+ regulatory T cells for immunologic self-tolerance and negative control of immune responses
    • S. Sakaguchi Naturally arising CD4+ regulatory T cells for immunologic self-tolerance and negative control of immune responses Annu Rev Immunol 22 2004 531 562
    • (2004) Annu Rev Immunol , vol.22 , pp. 531-562
    • Sakaguchi, S.1
  • 37
    • 32244445416 scopus 로고    scopus 로고
    • Natural regulatory T cells control the development of atherosclerosis in mice
    • H. Ait-Oufella, B.L. Salomon, and S. Potteaux Natural regulatory T cells control the development of atherosclerosis in mice Nat Med 12 2006 178 180
    • (2006) Nat Med , vol.12 , pp. 178-180
    • Ait-Oufella, H.1    Salomon, B.L.2    Potteaux, S.3
  • 39
    • 0346996879 scopus 로고    scopus 로고
    • The regulatory T cell family: Distinct subsets and their interrelations
    • H. Jonuleit, and E. Schmitt The regulatory T cell family: distinct subsets and their interrelations J Immunol 171 2003 6323 6327
    • (2003) J Immunol , vol.171 , pp. 6323-6327
    • Jonuleit, H.1    Schmitt, E.2
  • 40
    • 82755197890 scopus 로고    scopus 로고
    • Clinical perspectives for regulatory T cells in transplantation tolerance
    • K.L. Hippen, J.L. Riley, C.H. June, and B.R. Blazar Clinical perspectives for regulatory T cells in transplantation tolerance Semin Immunol 23 2011 462 468
    • (2011) Semin Immunol , vol.23 , pp. 462-468
    • Hippen, K.L.1    Riley, J.L.2    June, C.H.3    Blazar, B.R.4
  • 41
    • 0038631849 scopus 로고    scopus 로고
    • Type 1 T-regulatory cells: Their role in the control of immune responses
    • H. Groux Type 1 T-regulatory cells: their role in the control of immune responses Transplantation 75 9 suppl 2003 8S 12S
    • (2003) Transplantation , vol.75 , Issue.9 , pp. 8S-12S
    • Groux, H.1
  • 42
    • 0035862336 scopus 로고    scopus 로고
    • Differentiation of T regulatory cells by immature dendritic cells
    • M.G. Roncarolo, M.K. Levings, and C. Traversari Differentiation of T regulatory cells by immature dendritic cells J Exp Med 193 2001 F5 F9
    • (2001) J Exp Med , vol.193 , pp. 5-F9
    • Roncarolo, M.G.1    Levings, M.K.2    Traversari, C.3
  • 43
    • 0028724846 scopus 로고
    • The autocrine regulatory effect of vasoactive intestinal peptide on the growth of human pancreatic carcinoma cells
    • Y. Chen, Q. Chen, G. Lu, Z. Fan, and S. Zhong The autocrine regulatory effect of vasoactive intestinal peptide on the growth of human pancreatic carcinoma cells Chin Med Sci J 9 1994 215 219
    • (1994) Chin Med Sci J , vol.9 , pp. 215-219
    • Chen, Y.1    Chen, Q.2    Lu, G.3    Fan, Z.4    Zhong, S.5
  • 44
    • 77950349016 scopus 로고    scopus 로고
    • Th17 and regulatory T cells in mediating and restraining inflammation
    • D.R. Littman, and A.Y. Rudensky Th17 and regulatory T cells in mediating and restraining inflammation Cell 140 2010 845 858
    • (2010) Cell , vol.140 , pp. 845-858
    • Littman, D.R.1    Rudensky, A.Y.2
  • 45
    • 0035162560 scopus 로고    scopus 로고
    • Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse
    • M.E. Brunkow, E.W. Jeffery, and K.A. Hjerrild Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse Nat Genet 27 2001 68 73
    • (2001) Nat Genet , vol.27 , pp. 68-73
    • Brunkow, M.E.1    Jeffery, E.W.2    Hjerrild, K.A.3
  • 46
    • 33646168597 scopus 로고    scopus 로고
    • FOXP3: Of mice and men
    • S.F. Ziegler FOXP3: of mice and men Annu Rev Immunol 24 2006 209 226
    • (2006) Annu Rev Immunol , vol.24 , pp. 209-226
    • Ziegler, S.F.1
  • 47
    • 33746228122 scopus 로고    scopus 로고
    • FOXP3 controls regulatory T cell function through cooperation with NFAT
    • Y. Wu, M. Borde, and V. Heissmeyer FOXP3 controls regulatory T cell function through cooperation with NFAT Cell 126 2006 375 387
    • (2006) Cell , vol.126 , pp. 375-387
    • Wu, Y.1    Borde, M.2    Heissmeyer, V.3
  • 48
    • 33846980131 scopus 로고    scopus 로고
    • Epigenetic control of the foxp3 locus in regulatory T cells
    • S. Floess, J. Freyer, and C. Siewert Epigenetic control of the foxp3 locus in regulatory T cells PLoS Biol 5 2007 e38
    • (2007) PLoS Biol , vol.5 , pp. 38
    • Floess, S.1    Freyer, J.2    Siewert, C.3
  • 49
    • 84866548843 scopus 로고    scopus 로고
    • Transcription factor Foxp3 and its protein partners form a complex regulatory network
    • D. Rudra, P. deRoos, and A. Chaudhry Transcription factor Foxp3 and its protein partners form a complex regulatory network Nat Immunol 13 2012 1010 1019
    • (2012) Nat Immunol , vol.13 , pp. 1010-1019
    • Rudra, D.1    Deroos, P.2    Chaudhry, A.3
  • 50
    • 33847242598 scopus 로고    scopus 로고
    • Foxp3 occupancy and regulation of key target genes during T-cell stimulation
    • A. Marson, K. Kretschmer, and G.M. Frampton Foxp3 occupancy and regulation of key target genes during T-cell stimulation Nature 445 2007 931 935
    • (2007) Nature , vol.445 , pp. 931-935
    • Marson, A.1    Kretschmer, K.2    Frampton, G.M.3
  • 51
    • 33847220736 scopus 로고    scopus 로고
    • Genome-wide analysis of Foxp3 target genes in developing and mature regulatory T cells
    • Y. Zheng Genome-wide analysis of Foxp3 target genes in developing and mature regulatory T cells Nature 445 2007 936 940
    • (2007) Nature , vol.445 , pp. 936-940
    • Zheng, Y.1
  • 52
    • 84866975037 scopus 로고    scopus 로고
    • Foxp3 exploits a pre-existent enhancer landscape for regulatory T cell lineage specification
    • R.M. Samstein Foxp3 exploits a pre-existent enhancer landscape for regulatory T cell lineage specification Cell 151 2012 153 166
    • (2012) Cell , vol.151 , pp. 153-166
    • Samstein, R.M.1
  • 53
    • 84866533054 scopus 로고    scopus 로고
    • A multiply redundant genetic switch 'locks in' the transcriptional signature of regulatory T cells
    • W. Fu A multiply redundant genetic switch 'locks in' the transcriptional signature of regulatory T cells Nat Immunol 13 2012 972 980
    • (2012) Nat Immunol , vol.13 , pp. 972-980
    • Fu, W.1
  • 54
    • 0035313754 scopus 로고    scopus 로고
    • Mechanism of transcription initiation and promoter escape by RNA polymerase II
    • A. Dvir, J.W. Conaway, and R.C. Conaway Mechanism of transcription initiation and promoter escape by RNA polymerase II Curr Opin Genet Dev 11 2001 209 214
    • (2001) Curr Opin Genet Dev , vol.11 , pp. 209-214
    • Dvir, A.1    Conaway, J.W.2    Conaway, R.C.3
  • 55
    • 77957970301 scopus 로고    scopus 로고
    • Epigenetic modifications and human disease
    • A. Portela, and M. Esteller Epigenetic modifications and human disease Nat Biotechnol 28 2010 1057 1068
    • (2010) Nat Biotechnol , vol.28 , pp. 1057-1068
    • Portela, A.1    Esteller, M.2
  • 56
    • 84860371953 scopus 로고    scopus 로고
    • Epigenetic protein families: A new frontier for drug discovery
    • C.H. Arrowsmith Epigenetic protein families: a new frontier for drug discovery Nat Rev Drug Discov 11 2012 384 400
    • (2012) Nat Rev Drug Discov , vol.11 , pp. 384-400
    • Arrowsmith, C.H.1
  • 57
    • 0020489781 scopus 로고
    • Amount and distribution of 5-methylcytosine in human DNA from different types of tissues of cells
    • M. Ehrlich Amount and distribution of 5-methylcytosine in human DNA from different types of tissues of cells Nucleic Acids Res 10 1982 2709 2721
    • (1982) Nucleic Acids Res , vol.10 , pp. 2709-2721
    • Ehrlich, M.1
  • 58
    • 0036144048 scopus 로고    scopus 로고
    • DNA methylation patterns and epigenetic memory
    • A. Bird DNA methylation patterns and epigenetic memory Genes Dev 16 2002 6 21
    • (2002) Genes Dev , vol.16 , pp. 6-21
    • Bird, A.1
  • 59
    • 58849092225 scopus 로고    scopus 로고
    • Epigenetic control of T-helper-cell differentiation
    • C.B. Wilson, E. Rowell, and M. Sekimata Epigenetic control of T-helper-cell differentiation Nat Rev Immunol 9 2009 91 105
    • (2009) Nat Rev Immunol , vol.9 , pp. 91-105
    • Wilson, C.B.1    Rowell, E.2    Sekimata, M.3
  • 60
    • 36849073739 scopus 로고    scopus 로고
    • Hyperhomocysteinemia, DNA methylation and vascular disease
    • M.S. Jamaluddin, X. Yang, and H. Wang Hyperhomocysteinemia, DNA methylation and vascular disease Clin Chem Lab Med 45 2007 1660 1666
    • (2007) Clin Chem Lab Med , vol.45 , pp. 1660-1666
    • Jamaluddin, M.S.1    Yang, X.2    Wang, H.3
  • 61
    • 84879706600 scopus 로고    scopus 로고
    • Foxp3+ T-regulatory cells require DNA methyltransferase 1 expression to prevent development of lethal autoimmunity
    • L. Wang Foxp3+ T-regulatory cells require DNA methyltransferase 1 expression to prevent development of lethal autoimmunity Blood 121 2013 3631 3639
    • (2013) Blood , vol.121 , pp. 3631-3639
    • Wang, L.1
  • 62
    • 77950586365 scopus 로고    scopus 로고
    • DNA methyltransferases and methyl-binding proteins of mammals
    • J. Lan DNA methyltransferases and methyl-binding proteins of mammals Acta Biochim Biophys Sin (Shanghai) 42 2010 243 252
    • (2010) Acta Biochim Biophys Sin (Shanghai) , vol.42 , pp. 243-252
    • Lan, J.1
  • 63
    • 79952535972 scopus 로고    scopus 로고
    • Regulation and function of DNA methylation in plants and animals
    • X.J. He, T. Chen, and J.K. Zhu Regulation and function of DNA methylation in plants and animals Cell Res 21 2011 442 465
    • (2011) Cell Res , vol.21 , pp. 442-465
    • He, X.J.1    Chen, T.2    Zhu, J.K.3
  • 64
    • 77956095231 scopus 로고    scopus 로고
    • Active DNA demethylation: Many roads lead to Rome
    • S.C. Wu, and Y. Zhang Active DNA demethylation: many roads lead to Rome Nat Rev Mol Cell Biol 11 2010 607 620
    • (2010) Nat Rev Mol Cell Biol , vol.11 , pp. 607-620
    • Wu, S.C.1    Zhang, Y.2
  • 65
    • 84886860116 scopus 로고    scopus 로고
    • TET enzymes, TDG and the dynamics of DNA demethylation
    • R.M. Kohli, and Y. Zhang TET enzymes, TDG and the dynamics of DNA demethylation Nature 502 2013 472 479
    • (2013) Nature , vol.502 , pp. 472-479
    • Kohli, R.M.1    Zhang, Y.2
  • 66
    • 77951116072 scopus 로고    scopus 로고
    • CpG islands influence chromatin structure via the CpG-binding protein Cfp1
    • J.P. Thomson CpG islands influence chromatin structure via the CpG-binding protein Cfp1 Nature 464 2010 1082 1086
    • (2010) Nature , vol.464 , pp. 1082-1086
    • Thomson, J.P.1
  • 67
    • 0034968451 scopus 로고    scopus 로고
    • Emerging connections between DNA methylation and histone acetylation
    • J.R. Dobosy, and E.U. Selker Emerging connections between DNA methylation and histone acetylation Cell Mol Life Sci 58 2001 721 727
    • (2001) Cell Mol Life Sci , vol.58 , pp. 721-727
    • Dobosy, J.R.1    Selker, E.U.2
  • 68
    • 33847076849 scopus 로고    scopus 로고
    • Chromatin modifications and their function
    • T. Kouzarides Chromatin modifications and their function Cell 128 2007 693 705
    • (2007) Cell , vol.128 , pp. 693-705
    • Kouzarides, T.1
  • 69
    • 67650711140 scopus 로고    scopus 로고
    • Genome-wide views of chromatin structure
    • O.J. Rando, and H.Y. Chang Genome-wide views of chromatin structure Annu Rev Biochem 78 2009 245 271
    • (2009) Annu Rev Biochem , vol.78 , pp. 245-271
    • Rando, O.J.1    Chang, H.Y.2
  • 70
    • 35848936709 scopus 로고    scopus 로고
    • Cross-regulation of histone modifications
    • J.A. Latham, and S.Y. Dent Cross-regulation of histone modifications Nat Struct Mol Biol 14 2007 1017 1024
    • (2007) Nat Struct Mol Biol , vol.14 , pp. 1017-1024
    • Latham, J.A.1    Dent, S.Y.2
  • 71
  • 72
    • 0037979272 scopus 로고    scopus 로고
    • Methylation of histone H3 by Set2 in Saccharomyces cerevisiae is linked to transcriptional elongation by RNA polymerase II
    • N.J. Krogan Methylation of histone H3 by Set2 in Saccharomyces cerevisiae is linked to transcriptional elongation by RNA polymerase II Mol Cell Biol 23 2003 4207 4218
    • (2003) Mol Cell Biol , vol.23 , pp. 4207-4218
    • Krogan, N.J.1
  • 73
    • 0344022572 scopus 로고    scopus 로고
    • Targeted recruitment of Set1 histone methylase by elongating Pol II provides a localized mark and memory of recent transcriptional activity
    • H.H. Ng Targeted recruitment of Set1 histone methylase by elongating Pol II provides a localized mark and memory of recent transcriptional activity Mol Cell 11 2003 709 719
    • (2003) Mol Cell , vol.11 , pp. 709-719
    • Ng, H.H.1
  • 74
    • 0037179716 scopus 로고    scopus 로고
    • Active genes are tri-methylated at K4 of histone H3
    • H. Santos-Rosa Active genes are tri-methylated at K4 of histone H3 Nature 419 2002 407 411
    • (2002) Nature , vol.419 , pp. 407-411
    • Santos-Rosa, H.1
  • 75
    • 0037172993 scopus 로고    scopus 로고
    • Methylation of histone H3 Lys 4 in coding regions of active genes
    • B.E. Bernstein Methylation of histone H3 Lys 4 in coding regions of active genes Proc Natl Acad Sci U S A 99 2002 8695 8700
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 8695-8700
    • Bernstein, B.E.1
  • 76
    • 0014430407 scopus 로고
    • Chemical studies of histone acetylation. the distribution of epsilon-N-acetyllysine in calf thymus histones
    • G. Vidali, E.L. Gershey, and V.G. Allfrey Chemical studies of histone acetylation. The distribution of epsilon-N-acetyllysine in calf thymus histones J Biol Chem 243 1968 6361 6366
    • (1968) J Biol Chem , vol.243 , pp. 6361-6366
    • Vidali, G.1    Gershey, E.L.2    Allfrey, V.G.3
  • 77
    • 78651162036 scopus 로고
    • Acetylation and methylation of histones and their possible role in the regulation of RNA synthesis
    • V.G. Allfrey, R. Faulkner, and A.E. Mirsky Acetylation and methylation of histones and their possible role in the regulation of RNA synthesis Proc Natl Acad Sci U S A 51 1964 786 794
    • (1964) Proc Natl Acad Sci U S A , vol.51 , pp. 786-794
    • Allfrey, V.G.1    Faulkner, R.2    Mirsky, A.E.3
  • 78
    • 0036850325 scopus 로고    scopus 로고
    • Cellular memory and the histone code
    • B.M. Turner Cellular memory and the histone code Cell 111 2002 285 291
    • (2002) Cell , vol.111 , pp. 285-291
    • Turner, B.M.1
  • 79
    • 0034610814 scopus 로고    scopus 로고
    • The language of covalent histone modifications
    • B.D. Strahl, and C.D. Allis The language of covalent histone modifications Nature 403 2000 41 45
    • (2000) Nature , vol.403 , pp. 41-45
    • Strahl, B.D.1    Allis, C.D.2
  • 80
    • 2342599619 scopus 로고    scopus 로고
    • The diverse superfamily of lysine acetyltransferases and their roles in leukemia and other diseases
    • X.J. Yang The diverse superfamily of lysine acetyltransferases and their roles in leukemia and other diseases Nucleic Acids Res 32 2004 959 976
    • (2004) Nucleic Acids Res , vol.32 , pp. 959-976
    • Yang, X.J.1
  • 81
    • 36148991452 scopus 로고    scopus 로고
    • Phosphorylated serine 28 of histone H3 is associated with destabilized nucleosomes in transcribed chromatin
    • J.M. Sun Phosphorylated serine 28 of histone H3 is associated with destabilized nucleosomes in transcribed chromatin Nucleic Acids Res 35 2007 6640 6647
    • (2007) Nucleic Acids Res , vol.35 , pp. 6640-6647
    • Sun, J.M.1
  • 82
    • 23944474593 scopus 로고    scopus 로고
    • Intracellular protein degradation: From a vague idea thru the lysosome and the ubiquitin-proteasome system and onto human diseases and drug targeting
    • A. Ciechanover Intracellular protein degradation: from a vague idea thru the lysosome and the ubiquitin-proteasome system and onto human diseases and drug targeting Cell Death Differ 12 2005 1178 1190
    • (2005) Cell Death Differ , vol.12 , pp. 1178-1190
    • Ciechanover, A.1
  • 83
    • 33144469102 scopus 로고    scopus 로고
    • The proteasome and proteasome inhibitors in cancer therapy
    • P.M. Voorhees, and R.Z. Orlowski The proteasome and proteasome inhibitors in cancer therapy Annu Rev Pharmacol Toxicol 46 2006 189 213
    • (2006) Annu Rev Pharmacol Toxicol , vol.46 , pp. 189-213
    • Voorhees, P.M.1    Orlowski, R.Z.2
  • 84
    • 34147108606 scopus 로고    scopus 로고
    • Ubiquitylation of histone H2B controls RNA polymerase II transcription elongation independently of histone H3 methylation
    • J.C. Tanny Ubiquitylation of histone H2B controls RNA polymerase II transcription elongation independently of histone H3 methylation Genes Dev 21 2007 835 847
    • (2007) Genes Dev , vol.21 , pp. 835-847
    • Tanny, J.C.1
  • 85
    • 0344824404 scopus 로고    scopus 로고
    • Histone sumoylation is associated with transcriptional repression
    • Y. Shiio, and R.N. Eisenman Histone sumoylation is associated with transcriptional repression Proc Natl Acad Sci U S A 100 2003 13225 13230
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 13225-13230
    • Shiio, Y.1    Eisenman, R.N.2
  • 86
    • 80052172007 scopus 로고    scopus 로고
    • Histone ADP-ribosylation in DNA repair, replication and transcription
    • S. Messner, and M.O. Hottiger Histone ADP-ribosylation in DNA repair, replication and transcription Trends Cell Biol 21 2011 534 542
    • (2011) Trends Cell Biol , vol.21 , pp. 534-542
    • Messner, S.1    Hottiger, M.O.2
  • 87
    • 81355142141 scopus 로고    scopus 로고
    • Non-coding RNAs in human disease
    • M. Esteller Non-coding RNAs in human disease Nat Rev Genet 12 2011 861 874
    • (2011) Nat Rev Genet , vol.12 , pp. 861-874
    • Esteller, M.1
  • 88
    • 77958576363 scopus 로고    scopus 로고
    • Interaction of noncoding RNA with the rDNA promoter mediates recruitment of DNMT3b and silencing of rRNA genes
    • K.M. Schmitz Interaction of noncoding RNA with the rDNA promoter mediates recruitment of DNMT3b and silencing of rRNA genes Genes Dev 24 2010 2264 2269
    • (2010) Genes Dev , vol.24 , pp. 2264-2269
    • Schmitz, K.M.1
  • 89
    • 18244365863 scopus 로고    scopus 로고
    • A critical role for Dnmt1 and DNA methylation in T cell development, function, and survival
    • P.P. Lee A critical role for Dnmt1 and DNA methylation in T cell development, function, and survival Immunity 15 2001 763 774
    • (2001) Immunity , vol.15 , pp. 763-774
    • Lee, P.P.1
  • 90
    • 84875458605 scopus 로고    scopus 로고
    • Active demethylation of the Foxp3 locus leads to the generation of stable regulatory T cells within the thymus
    • A. Toker Active demethylation of the Foxp3 locus leads to the generation of stable regulatory T cells within the thymus J Immunol 190 2013 3180 3188
    • (2013) J Immunol , vol.190 , pp. 3180-3188
    • Toker, A.1
  • 91
    • 78149408519 scopus 로고    scopus 로고
    • Methylation matters: Binding of Ets-1 to the demethylated Foxp3 gene contributes to the stabilization of Foxp3 expression in regulatory T cells
    • J.K. Polansky Methylation matters: binding of Ets-1 to the demethylated Foxp3 gene contributes to the stabilization of Foxp3 expression in regulatory T cells J Mol Med (Berl) 88 2010 1029 1040
    • (2010) J Mol Med (Berl) , vol.88 , pp. 1029-1040
    • Polansky, J.K.1
  • 92
    • 33747801470 scopus 로고    scopus 로고
    • IL-2 regulates FOXP3 expression in human CD4+CD25+ regulatory T cells through a STAT-dependent mechanism and induces the expansion of these cells in vivo
    • E. Zorn IL-2 regulates FOXP3 expression in human CD4+CD25+ regulatory T cells through a STAT-dependent mechanism and induces the expansion of these cells in vivo Blood 108 2006 1571 1579
    • (2006) Blood , vol.108 , pp. 1571-1579
    • Zorn, E.1
  • 93
    • 34548755672 scopus 로고    scopus 로고
    • DNA demethylation in the human FOXP3 locus discriminates regulatory T cells from activated FOXP3(+) conventional T cells
    • U. Baron DNA demethylation in the human FOXP3 locus discriminates regulatory T cells from activated FOXP3(+) conventional T cells Eur J Immunol 37 2007 2378 2389
    • (2007) Eur J Immunol , vol.37 , pp. 2378-2389
    • Baron, U.1
  • 94
    • 49649107703 scopus 로고    scopus 로고
    • DNA methylation controls Foxp3 gene expression
    • J.K. Polansky DNA methylation controls Foxp3 gene expression Eur J Immunol 38 2008 1654 1663
    • (2008) Eur J Immunol , vol.38 , pp. 1654-1663
    • Polansky, J.K.1
  • 95
    • 34447265236 scopus 로고    scopus 로고
    • CREB/ATF-dependent T cell receptor-induced FoxP3 gene expression: A role for DNA methylation
    • H.P. Kim, and W.J. Leonard CREB/ATF-dependent T cell receptor-induced FoxP3 gene expression: a role for DNA methylation J Exp Med 204 2007 1543 1551
    • (2007) J Exp Med , vol.204 , pp. 1543-1551
    • Kim, H.P.1    Leonard, W.J.2
  • 96
    • 76749133610 scopus 로고    scopus 로고
    • Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate
    • Y. Zheng Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate Nature 463 2010 808 812
    • (2010) Nature , vol.463 , pp. 808-812
    • Zheng, Y.1
  • 97
    • 84888377490 scopus 로고    scopus 로고
    • Active demethylation of the IL-2 promoter in CD4+ T cells is mediated by an inducible DNA glycosylase, Myh
    • L. Wu, and Q. Zheng Active demethylation of the IL-2 promoter in CD4+ T cells is mediated by an inducible DNA glycosylase, Myh Mol Immunol 58 2014 38 49
    • (2014) Mol Immunol , vol.58 , pp. 38-49
    • Wu, L.1    Zheng, Q.2
  • 98
    • 34848876937 scopus 로고    scopus 로고
    • Cutting edge: Trans-signaling via the soluble IL-6R abrogates the induction of FoxP3 in naive CD4+CD25 T cells
    • S. Dominitzki Cutting edge: trans-signaling via the soluble IL-6R abrogates the induction of FoxP3 in naive CD4+CD25 T cells J Immunol 179 2007 2041 2045
    • (2007) J Immunol , vol.179 , pp. 2041-2045
    • Dominitzki, S.1
  • 99
    • 52949138267 scopus 로고    scopus 로고
    • TGF-beta and IL-6 signals modulate chromatin binding and promoter occupancy by acetylated FOXP3
    • A. Samanta TGF-beta and IL-6 signals modulate chromatin binding and promoter occupancy by acetylated FOXP3 Proc Natl Acad Sci U S A 105 2008 14023 14027
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 14023-14027
    • Samanta, A.1
  • 100
    • 23944471116 scopus 로고    scopus 로고
    • Pathological role of IL-6 in the experimental allergic bronchial asthma in mice
    • A. Doganci Pathological role of IL-6 in the experimental allergic bronchial asthma in mice Clin Rev Allergy Immunol 28 2005 257 270
    • (2005) Clin Rev Allergy Immunol , vol.28 , pp. 257-270
    • Doganci, A.1
  • 101
    • 76549088622 scopus 로고    scopus 로고
    • Stat 3 signal transduction pathway correlates with proliferation of vascular smooth muscle cells of rats
    • M. Tang Stat 3 signal transduction pathway correlates with proliferation of vascular smooth muscle cells of rats Zhonghua Xin Xue Guan Bing Za Zhi 33 2005 832 835
    • (2005) Zhonghua Xin Xue Guan Bing Za Zhi , vol.33 , pp. 832-835
    • Tang, M.1
  • 102
    • 78049240315 scopus 로고    scopus 로고
    • Histone acetyltransferase mediated regulation of FOXP3 acetylation and Treg function
    • Y. Xiao Histone acetyltransferase mediated regulation of FOXP3 acetylation and Treg function Curr Opin Immunol 22 2010 583 591
    • (2010) Curr Opin Immunol , vol.22 , pp. 583-591
    • Xiao, Y.1
  • 103
    • 77649225958 scopus 로고    scopus 로고
    • Regulation of Treg functionality by acetylation-mediated Foxp3 protein stabilization
    • J. van Loosdregt Regulation of Treg functionality by acetylation-mediated Foxp3 protein stabilization Blood 115 2010 965 974
    • (2010) Blood , vol.115 , pp. 965-974
    • Van Loosdregt, J.1
  • 104
    • 37149018400 scopus 로고    scopus 로고
    • FOXP3 actively represses transcription by recruiting the HAT/HDAC complex
    • B. Li, and M.I. Greene FOXP3 actively represses transcription by recruiting the HAT/HDAC complex Cell Cycle 6 2007 1432 1436
    • (2007) Cell Cycle , vol.6 , pp. 1432-1436
    • Li, B.1    Greene, M.I.2
  • 105
    • 34248379172 scopus 로고    scopus 로고
    • FOXP3 interactions with histone acetyltransferase and class II histone deacetylases are required for repression
    • B. Li FOXP3 interactions with histone acetyltransferase and class II histone deacetylases are required for repression Proc Natl Acad Sci U S A 104 2007 4571 4576
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 4571-4576
    • Li, B.1
  • 106
    • 84883767441 scopus 로고    scopus 로고
    • Inhibition of p300 impairs Foxp3(+) T regulatory cell function and promotes antitumor immunity
    • Y. Liu Inhibition of p300 impairs Foxp3(+) T regulatory cell function and promotes antitumor immunity Nat Med 19 2013 1173 1177
    • (2013) Nat Med , vol.19 , pp. 1173-1177
    • Liu, Y.1
  • 107
    • 79955438868 scopus 로고    scopus 로고
    • Rapid temporal control of Foxp3 protein degradation by sirtuin-1
    • J. van Loosdregt Rapid temporal control of Foxp3 protein degradation by sirtuin-1 PLoS One 6 2011 e19047
    • (2011) PLoS One , vol.6 , pp. 19047
    • Van Loosdregt, J.1
  • 108
    • 77955277730 scopus 로고    scopus 로고
    • Histone/protein deacetylase inhibitors increase suppressive functions of human FOXP3+ Tregs
    • T. Akimova Histone/protein deacetylase inhibitors increase suppressive functions of human FOXP3+ Tregs Clin Immunol 136 2010 348 363
    • (2010) Clin Immunol , vol.136 , pp. 348-363
    • Akimova, T.1
  • 109
    • 34848868141 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors and transplantation
    • R. Tao Histone deacetylase inhibitors and transplantation Curr Opin Immunol 19 2007 589 595
    • (2007) Curr Opin Immunol , vol.19 , pp. 589-595
    • Tao, R.1
  • 110
    • 84862881397 scopus 로고    scopus 로고
    • Histone deacetylases 6 and 9 and sirtuin-1 control Foxp3+ regulatory T cell function through shared and isoform-specific mechanisms
    • U.H. Beier Histone deacetylases 6 and 9 and sirtuin-1 control Foxp3+ regulatory T cell function through shared and isoform-specific mechanisms Sci Signal 5 2012 ra45
    • (2012) Sci Signal , vol.5 , pp. 45
    • Beier, U.H.1
  • 111
    • 17144414861 scopus 로고    scopus 로고
    • Protein kinase D1 phosphorylates HDAC7 and induces its nuclear export after T-cell receptor activation
    • M. Parra Protein kinase D1 phosphorylates HDAC7 and induces its nuclear export after T-cell receptor activation J Biol Chem 280 2005 13762 13770
    • (2005) J Biol Chem , vol.280 , pp. 13762-13770
    • Parra, M.1
  • 112
    • 15444375044 scopus 로고    scopus 로고
    • Phosphorylation of histone deacetylase 7 by protein kinase D mediates T cell receptor-induced Nur77 expression and apoptosis
    • F. Dequiedt Phosphorylation of histone deacetylase 7 by protein kinase D mediates T cell receptor-induced Nur77 expression and apoptosis J Exp Med 201 2005 793 804
    • (2005) J Exp Med , vol.201 , pp. 793-804
    • Dequiedt, F.1
  • 113
    • 0036787922 scopus 로고    scopus 로고
    • Association of class II histone deacetylases with heterochromatin protein 1: Potential role for histone methylation in control of muscle differentiation
    • C.L. Zhang, T.A. McKinsey, and E.N. Olson Association of class II histone deacetylases with heterochromatin protein 1: potential role for histone methylation in control of muscle differentiation Mol Cell Biol 22 2002 7302 7312
    • (2002) Mol Cell Biol , vol.22 , pp. 7302-7312
    • Zhang, C.L.1    McKinsey, T.A.2    Olson, E.N.3
  • 114
    • 0037162697 scopus 로고    scopus 로고
    • Class II histone deacetylases act as signal-responsive repressors of cardiac hypertrophy
    • C.L. Zhang Class II histone deacetylases act as signal-responsive repressors of cardiac hypertrophy Cell 110 2002 479 488
    • (2002) Cell , vol.110 , pp. 479-488
    • Zhang, C.L.1
  • 115
    • 70349440053 scopus 로고    scopus 로고
    • The type III histone deacetylase Sirt1 is essential for maintenance of T cell tolerance in mice
    • J. Zhang The type III histone deacetylase Sirt1 is essential for maintenance of T cell tolerance in mice J Clin Invest 119 2009 3048 3058
    • (2009) J Clin Invest , vol.119 , pp. 3048-3058
    • Zhang, J.1
  • 116
    • 79952274915 scopus 로고    scopus 로고
    • Sirtuin-1 targeting promotes Foxp3+ T-regulatory cell function and prolongs allograft survival
    • U.H. Beier Sirtuin-1 targeting promotes Foxp3+ T-regulatory cell function and prolongs allograft survival Mol Cell Biol 31 2011 1022 1029
    • (2011) Mol Cell Biol , vol.31 , pp. 1022-1029
    • Beier, U.H.1
  • 117
    • 44649163849 scopus 로고    scopus 로고
    • Mechanisms involved in the regulation of histone lysine demethylases
    • F. Lan, A.C. Nottke, and Y. Shi Mechanisms involved in the regulation of histone lysine demethylases Curr Opin Cell Biol 20 2008 316 325
    • (2008) Curr Opin Cell Biol , vol.20 , pp. 316-325
    • Lan, F.1    Nottke, A.C.2    Shi, Y.3
  • 118
    • 84893482395 scopus 로고    scopus 로고
    • The histone methyltransferase Ezh2 is a crucial epigenetic regulator of allogeneic T-cell responses mediating graft-versus-host disease
    • S. He The histone methyltransferase Ezh2 is a crucial epigenetic regulator of allogeneic T-cell responses mediating graft-versus-host disease Blood 122 2013 4119 4128
    • (2013) Blood , vol.122 , pp. 4119-4128
    • He, S.1
  • 119
    • 81755171935 scopus 로고    scopus 로고
    • Global mapping of H3K4me1 and H3K4me3 reveals the chromatin state-based cell type-specific gene regulation in human Treg cells
    • Y. Tian Global mapping of H3K4me1 and H3K4me3 reveals the chromatin state-based cell type-specific gene regulation in human Treg cells PLoS One 6 2011 e27770
    • (2011) PLoS One , vol.6 , pp. 27770
    • Tian, Y.1
  • 120
    • 84893605170 scopus 로고    scopus 로고
    • Histone methylation mediates plasticity of human FOXP3(+) regulatory T cells by modulating signature gene expressions
    • H. He Histone methylation mediates plasticity of human FOXP3(+) regulatory T cells by modulating signature gene expressions Immunology 141 2014 362 376
    • (2014) Immunology , vol.141 , pp. 362-376
    • He, H.1
  • 121
    • 84899761239 scopus 로고    scopus 로고
    • Methyltransferase G9A regulates T cell differentiation during murine intestinal inflammation
    • F. Antignano Methyltransferase G9A regulates T cell differentiation during murine intestinal inflammation J Clin Invest 124 2014 1945 1955
    • (2014) J Clin Invest , vol.124 , pp. 1945-1955
    • Antignano, F.1
  • 122
    • 84886875425 scopus 로고    scopus 로고
    • Mbd2 promotes foxp3 demethylation and T-regulatory-cell function
    • L. Wang Mbd2 promotes foxp3 demethylation and T-regulatory-cell function Mol Cell Biol 33 2013 4106 4115
    • (2013) Mol Cell Biol , vol.33 , pp. 4106-4115
    • Wang, L.1
  • 123
    • 20844432885 scopus 로고    scopus 로고
    • T cell lineage choice and differentiation in the absence of the RNase III enzyme Dicer
    • B.S. Cobb T cell lineage choice and differentiation in the absence of the RNase III enzyme Dicer J Exp Med 201 2005 1367 1373
    • (2005) J Exp Med , vol.201 , pp. 1367-1373
    • Cobb, B.S.1
  • 124
    • 22944433872 scopus 로고    scopus 로고
    • Aberrant T cell differentiation in the absence of Dicer
    • S.A. Muljo Aberrant T cell differentiation in the absence of Dicer J Exp Med 202 2005 261 269
    • (2005) J Exp Med , vol.202 , pp. 261-269
    • Muljo, S.A.1
  • 125
    • 51049110261 scopus 로고    scopus 로고
    • Dicer-dependent microRNA pathway safeguards regulatory T cell function
    • A. Liston Dicer-dependent microRNA pathway safeguards regulatory T cell function J Exp Med 205 2008 1993 2004
    • (2008) J Exp Med , vol.205 , pp. 1993-2004
    • Liston, A.1
  • 126
    • 51049120236 scopus 로고    scopus 로고
    • Selective miRNA disruption in T reg cells leads to uncontrolled autoimmunity
    • X. Zhou Selective miRNA disruption in T reg cells leads to uncontrolled autoimmunity J Exp Med 205 2008 1983 1991
    • (2008) J Exp Med , vol.205 , pp. 1983-1991
    • Zhou, X.1
  • 127
    • 0024344852 scopus 로고
    • Multiple proto-oncogene activations in avian leukosis virus-induced lymphomas: Evidence for stage-specific events
    • B.E. Clurman, and W.S. Hayward Multiple proto-oncogene activations in avian leukosis virus-induced lymphomas: evidence for stage-specific events Mol Cell Biol 9 1989 2657 2664
    • (1989) Mol Cell Biol , vol.9 , pp. 2657-2664
    • Clurman, B.E.1    Hayward, W.S.2
  • 128
    • 14844354250 scopus 로고    scopus 로고
    • Accumulation of miR-155 and BIC RNA in human B cell lymphomas
    • P.S. Eis, W. Tam, and L. Sun Accumulation of miR-155 and BIC RNA in human B cell lymphomas Proc Natl Acad Sci U S A 102 2005 3627 3632
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 3627-3632
    • Eis, P.S.1    Tam, W.2    Sun, L.3
  • 129
    • 34247584465 scopus 로고    scopus 로고
    • Requirement of bic/microRNA-155 for normal immune function
    • A. Rodriguez, E. Vigorito, and S. Clare Requirement of bic/microRNA-155 for normal immune function Science 316 2007 608 611
    • (2007) Science , vol.316 , pp. 608-611
    • Rodriguez, A.1    Vigorito, E.2    Clare, S.3
  • 130
    • 34247594818 scopus 로고    scopus 로고
    • Regulation of the germinal center response by microRNA-155
    • T.H. Thai, D.P. Calado, and S. Casola Regulation of the germinal center response by microRNA-155 Science 316 2007 604 608
    • (2007) Science , vol.316 , pp. 604-608
    • Thai, T.H.1    Calado, D.P.2    Casola, S.3
  • 131
    • 70349503690 scopus 로고    scopus 로고
    • MiR-155 inhibition sensitizes CD4+ Th cells for TREG mediated suppression
    • H.F. Stahl miR-155 inhibition sensitizes CD4+ Th cells for TREG mediated suppression PLoS One 4 2009 e7158
    • (2009) PLoS One , vol.4 , pp. 7158
    • Stahl, H.F.1
  • 132
    • 64849100152 scopus 로고    scopus 로고
    • Cutting edge: The Foxp3 target miR-155 contributes to the development of regulatory T cells
    • S. Kohlhaas Cutting edge: the Foxp3 target miR-155 contributes to the development of regulatory T cells J Immunol 182 2009 2578 2582
    • (2009) J Immunol , vol.182 , pp. 2578-2582
    • Kohlhaas, S.1
  • 133
    • 58149268107 scopus 로고    scopus 로고
    • Foxp3-dependent microRNA155 confers competitive fitness to regulatory T cells by targeting SOCS1 protein
    • L.F. Lu Foxp3-dependent microRNA155 confers competitive fitness to regulatory T cells by targeting SOCS1 protein Immunity 30 2009 80 91
    • (2009) Immunity , vol.30 , pp. 80-91
    • Lu, L.F.1
  • 134
    • 84867584246 scopus 로고    scopus 로고
    • MicroRNA-155 modulates Treg and Th17 cells differentiation and Th17 cell function by targeting SOCS1
    • R. Yao MicroRNA-155 modulates Treg and Th17 cells differentiation and Th17 cell function by targeting SOCS1 PLoS One 7 2012 e46082
    • (2012) PLoS One , vol.7 , pp. 46082
    • Yao, R.1
  • 135
    • 69049110875 scopus 로고    scopus 로고
    • SOCS1 negatively regulates the production of Foxp3+ CD4+ T cells in the thymus
    • Y. Zhan SOCS1 negatively regulates the production of Foxp3+ CD4+ T cells in the thymus Immunol Cell Biol 87 2009 473 480
    • (2009) Immunol Cell Biol , vol.87 , pp. 473-480
    • Zhan, Y.1
  • 136
    • 52949151882 scopus 로고    scopus 로고
    • New insights into the roles of Stat5a/b and Stat3 in T cell development and differentiation
    • L. Wei, A. Laurence, and J.J. O'Shea New insights into the roles of Stat5a/b and Stat3 in T cell development and differentiation Semin Cell Dev Biol 19 2008 394 400
    • (2008) Semin Cell Dev Biol , vol.19 , pp. 394-400
    • Wei, L.1    Laurence, A.2    O'Shea, J.J.3
  • 137
    • 38449083826 scopus 로고    scopus 로고
    • IL-2 signaling and CD4+ CD25+ Foxp3+ regulatory T cells
    • L.A. Turka, and P.T. Walsh IL-2 signaling and CD4+ CD25+ Foxp3+ regulatory T cells Front Biosci 13 2008 1440 1446
    • (2008) Front Biosci , vol.13 , pp. 1440-1446
    • Turka, L.A.1    Walsh, P.T.2
  • 138
    • 16444371427 scopus 로고    scopus 로고
    • A SOCS-1 peptide mimetic inhibits both constitutive and IL-6 induced activation of STAT3 in prostate cancer cells
    • L.O. Flowers, P.S. Subramaniam, and H.M. Johnson A SOCS-1 peptide mimetic inhibits both constitutive and IL-6 induced activation of STAT3 in prostate cancer cells Oncogene 24 2005 2114 2120
    • (2005) Oncogene , vol.24 , pp. 2114-2120
    • Flowers, L.O.1    Subramaniam, P.S.2    Johnson, H.M.3
  • 139
    • 79952246179 scopus 로고    scopus 로고
    • The kinase inhibitory region of SOCS-1 is sufficient to inhibit T-helper 17 and other immune functions in experimental allergic encephalomyelitis
    • L.D. Jager The kinase inhibitory region of SOCS-1 is sufficient to inhibit T-helper 17 and other immune functions in experimental allergic encephalomyelitis J Neuroimmunol 232 2011 108 118
    • (2011) J Neuroimmunol , vol.232 , pp. 108-118
    • Jager, L.D.1
  • 140
    • 80054933795 scopus 로고    scopus 로고
    • Suppressor of cytokine signaling-1 (SOCS1) inhibits lymphocyte recruitment into the retina and protects SOCS1 transgenic rats and mice from ocular inflammation
    • C.R. Yu, R.R. Mahdi, and H.M. Oh Suppressor of cytokine signaling-1 (SOCS1) inhibits lymphocyte recruitment into the retina and protects SOCS1 transgenic rats and mice from ocular inflammation Invest Ophthalmol Vis Sci 52 2011 6978 6986
    • (2011) Invest Ophthalmol Vis Sci , vol.52 , pp. 6978-6986
    • Yu, C.R.1    Mahdi, R.R.2    Oh, H.M.3
  • 141
    • 67649349865 scopus 로고    scopus 로고
    • MicroRNA-125a-5p partly regulates the inflammatory response, lipid uptake, and ORP9 expression in oxLDL-stimulated monocyte/macrophages
    • T. Chen, Z. Huang, and L. Wang MicroRNA-125a-5p partly regulates the inflammatory response, lipid uptake, and ORP9 expression in oxLDL-stimulated monocyte/macrophages Cardiovasc Res 83 2009 131 139
    • (2009) Cardiovasc Res , vol.83 , pp. 131-139
    • Chen, T.1    Huang, Z.2    Wang, L.3
  • 142
    • 84866184313 scopus 로고    scopus 로고
    • Hematopoietic miR155 deficiency enhances atherosclerosis and decreases plaque stability in hyperlipidemic mice
    • M.M. Donners, I.M. Wolfs, and L.J. Stoger Hematopoietic miR155 deficiency enhances atherosclerosis and decreases plaque stability in hyperlipidemic mice PLoS One 7 2012 e35877
    • (2012) PLoS One , vol.7 , pp. 35877
    • Donners, M.M.1    Wolfs, I.M.2    Stoger, L.J.3
  • 143
    • 84869864800 scopus 로고    scopus 로고
    • Epidemiology of environmental exposures and human autoimmune diseases: Findings from a National Institute of Environmental Health Sciences Expert Panel Workshop
    • F.W. Miller, L. Alfredsson, and K.H. Costenbader Epidemiology of environmental exposures and human autoimmune diseases: findings from a National Institute of Environmental Health Sciences Expert Panel Workshop J Autoimmun 39 2012 259 271
    • (2012) J Autoimmun , vol.39 , pp. 259-271
    • Miller, F.W.1    Alfredsson, L.2    Costenbader, K.H.3
  • 144
    • 84869864007 scopus 로고    scopus 로고
    • Criteria for environmentally associated autoimmune diseases
    • F.W. Miller, K.M. Pollard, and C.G. Parks Criteria for environmentally associated autoimmune diseases J Autoimmun 39 2012 253 258
    • (2012) J Autoimmun , vol.39 , pp. 253-258
    • Miller, F.W.1    Pollard, K.M.2    Parks, C.G.3
  • 145
    • 84869881809 scopus 로고    scopus 로고
    • Epigenetics, autoimmunity and hematologic malignancies: A comprehensive review
    • O. Ngalamika, Y. Zhang, H. Yin, M. Zhao, M.E. Gershwin, and Q. Lu Epigenetics, autoimmunity and hematologic malignancies: a comprehensive review J Autoimmun 39 2012 451 465
    • (2012) J Autoimmun , vol.39 , pp. 451-465
    • Ngalamika, O.1    Zhang, Y.2    Yin, H.3    Zhao, M.4    Gershwin, M.E.5    Lu, Q.6
  • 146
    • 84869863290 scopus 로고    scopus 로고
    • Mechanisms of environmental influence on human autoimmunity: A National Institute of Environmental Health Sciences expert panel workshop
    • C. Selmi, P.S. Leung, and D.H. Sherr Mechanisms of environmental influence on human autoimmunity: a National Institute of Environmental Health Sciences expert panel workshop J Autoimmun 39 2012 272 284
    • (2012) J Autoimmun , vol.39 , pp. 272-284
    • Selmi, C.1    Leung, P.S.2    Sherr, D.H.3
  • 147
    • 84869886531 scopus 로고    scopus 로고
    • Heritability versus the role of the environment in autoimmunity
    • C. Selmi, Q. Lu, and M.C. Humble Heritability versus the role of the environment in autoimmunity J Autoimmun 39 2012 249 252
    • (2012) J Autoimmun , vol.39 , pp. 249-252
    • Selmi, C.1    Lu, Q.2    Humble, M.C.3
  • 148
    • 84865587194 scopus 로고    scopus 로고
    • Environmental triggers and epigenetic deregulation in autoimmune disease
    • B.M. Javierre, H. Hernando, and E. Ballestar Environmental triggers and epigenetic deregulation in autoimmune disease Discov Med 12 2011 535 545
    • (2011) Discov Med , vol.12 , pp. 535-545
    • Javierre, B.M.1    Hernando, H.2    Ballestar, E.3
  • 149
    • 84868374218 scopus 로고    scopus 로고
    • Epigenetics in inflammatory bowel disease
    • A.C. Jenke, and M. Zilbauer Epigenetics in inflammatory bowel disease Curr Opin Gastroenterol 28 2012 577 584
    • (2012) Curr Opin Gastroenterol , vol.28 , pp. 577-584
    • Jenke, A.C.1    Zilbauer, M.2
  • 150
    • 77958495102 scopus 로고    scopus 로고
    • MicroRNA-155 promotes autoimmune inflammation by enhancing inflammatory T cell development
    • R.M. O'Connell, D. Kahn, and W.S. Gibson MicroRNA-155 promotes autoimmune inflammation by enhancing inflammatory T cell development Immunity 33 2010 607 619
    • (2010) Immunity , vol.33 , pp. 607-619
    • O'Connell, R.M.1    Kahn, D.2    Gibson, W.S.3
  • 151
    • 33646471662 scopus 로고    scopus 로고
    • Pre-B cell proliferation and lymphoblastic leukemia/high-grade lymphoma in E(mu)-miR155 transgenic mice
    • S. Costinean, N. Zanesi, and Y. Pekarsky Pre-B cell proliferation and lymphoblastic leukemia/high-grade lymphoma in E(mu)-miR155 transgenic mice Proc Natl Acad Sci U S A 103 2006 7024 7029
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 7024-7029
    • Costinean, S.1    Zanesi, N.2    Pekarsky, Y.3
  • 152
    • 79956294973 scopus 로고    scopus 로고
    • DNA methylation and demethylation in mammals
    • Z.X. Chen, and A.D. Riggs DNA methylation and demethylation in mammals J Biol Chem 286 2011 18347 18353
    • (2011) J Biol Chem , vol.286 , pp. 18347-18353
    • Chen, Z.X.1    Riggs, A.D.2
  • 153
    • 70949097273 scopus 로고    scopus 로고
    • Induction of Foxp3 demethylation increases regulatory CD4+CD25+ T cells and prevents the occurrence of diabetes in mice
    • Q. Zheng, Y. Xu, and Y. Liu Induction of Foxp3 demethylation increases regulatory CD4+CD25+ T cells and prevents the occurrence of diabetes in mice J Mol Med (Berl) 87 2009 1191 1205
    • (2009) J Mol Med (Berl) , vol.87 , pp. 1191-1205
    • Zheng, Q.1    Xu, Y.2    Liu, Y.3
  • 154
    • 77955900102 scopus 로고    scopus 로고
    • In vivo administration of hypomethylating agents mitigate graft-versus-host disease without sacrificing graft-versus-leukemia
    • J. Choi, J. Ritchey, and J.L. Prior In vivo administration of hypomethylating agents mitigate graft-versus-host disease without sacrificing graft-versus-leukemia Blood 116 2010 129 139
    • (2010) Blood , vol.116 , pp. 129-139
    • Choi, J.1    Ritchey, J.2    Prior, J.L.3
  • 155
    • 31344460650 scopus 로고    scopus 로고
    • Optimizing therapy with methylation inhibitors in myelodysplastic syndromes: Dose, duration, and patient selection
    • J.P. Issa Optimizing therapy with methylation inhibitors in myelodysplastic syndromes: dose, duration, and patient selection Nat Clin Pract Oncol 2 suppl 1 2005 S24 S29
    • (2005) Nat Clin Pract Oncol , vol.2 , pp. 24-S29
    • Issa, J.P.1
  • 156
    • 79251504611 scopus 로고    scopus 로고
    • Control of DNMT1 abundance in epigenetic inheritance by acetylation, ubiquitylation, and the histone code
    • C. Bronner Control of DNMT1 abundance in epigenetic inheritance by acetylation, ubiquitylation, and the histone code Sci Signal 4 2011 pe3
    • (2011) Sci Signal , vol.4 , pp. 3
    • Bronner, C.1
  • 157
    • 78650981194 scopus 로고    scopus 로고
    • A methylation and phosphorylation switch between an adjacent lysine and serine determines human DNMT1 stability
    • P.O. Esteve, Y. Chang, and M. Samaranayake A methylation and phosphorylation switch between an adjacent lysine and serine determines human DNMT1 stability Nat Struct Mol Biol 18 2011 42 48
    • (2011) Nat Struct Mol Biol , vol.18 , pp. 42-48
    • Esteve, P.O.1    Chang, Y.2    Samaranayake, M.3
  • 158
    • 84863012446 scopus 로고    scopus 로고
    • Inhibition of histone methylation arrests ongoing graft-versus-host disease in mice by selectively inducing apoptosis of alloreactive effector T cells
    • S. He, J. Wang, and K. Kato Inhibition of histone methylation arrests ongoing graft-versus-host disease in mice by selectively inducing apoptosis of alloreactive effector T cells Blood 119 2012 1274 1282
    • (2012) Blood , vol.119 , pp. 1274-1282
    • He, S.1    Wang, J.2    Kato, K.3
  • 159
    • 0041915628 scopus 로고    scopus 로고
    • Induction of a regulatory T cell type 1 response reduces the development of atherosclerosis in apolipoprotein E-knockout mice
    • Z. Mallat, A. Gojova, and V. Brun Induction of a regulatory T cell type 1 response reduces the development of atherosclerosis in apolipoprotein E-knockout mice Circulation 108 2003 1232 1237
    • (2003) Circulation , vol.108 , pp. 1232-1237
    • Mallat, Z.1    Gojova, A.2    Brun, V.3
  • 160
    • 34247190299 scopus 로고    scopus 로고
    • Role of naturally occurring CD4+ CD25+ regulatory T cells in experimental atherosclerosis
    • A. Mor, D. Planer, and G. Luboshits Role of naturally occurring CD4+ CD25+ regulatory T cells in experimental atherosclerosis Arterioscler Thromb Vasc Biol 27 2007 893 900
    • (2007) Arterioscler Thromb Vasc Biol , vol.27 , pp. 893-900
    • Mor, A.1    Planer, D.2    Luboshits, G.3
  • 161
    • 84878109610 scopus 로고    scopus 로고
    • Methylation of FOXP3 in regulatory T cells is related to the severity of coronary artery disease
    • L. Jia, L. Zhu, and J.Z. Wang Methylation of FOXP3 in regulatory T cells is related to the severity of coronary artery disease Atherosclerosis 228 2013 346 352
    • (2013) Atherosclerosis , vol.228 , pp. 346-352
    • Jia, L.1    Zhu, L.2    Wang, J.Z.3
  • 162
    • 0041866794 scopus 로고    scopus 로고
    • Increased homocysteine and S-adenosylhomocysteine concentrations and DNA hypomethylation in vascular disease
    • R. Castro, I. Rivera, and E.A. Struys Increased homocysteine and S-adenosylhomocysteine concentrations and DNA hypomethylation in vascular disease Clin Chem 49 2003 1292 1296
    • (2003) Clin Chem , vol.49 , pp. 1292-1296
    • Castro, R.1    Rivera, I.2    Struys, E.A.3
  • 163
    • 36348971786 scopus 로고    scopus 로고
    • Homocysteine inhibits endothelial cell growth via DNA hypomethylation of the cyclin A gene
    • M.D. Jamaluddin, I. Chen, and F. Yang Homocysteine inhibits endothelial cell growth via DNA hypomethylation of the cyclin A gene Blood 110 2007 3648 3655
    • (2007) Blood , vol.110 , pp. 3648-3655
    • Jamaluddin, M.D.1    Chen, I.2    Yang, F.3
  • 164
    • 33750314730 scopus 로고    scopus 로고
    • Altered status of CD4(+)CD25(+) regulatory T cells in patients with acute coronary syndromes
    • A. Mor, G. Luboshits, D. Planer, G. Keren, and J. George Altered status of CD4(+)CD25(+) regulatory T cells in patients with acute coronary syndromes Eur Heart J 27 2006 2530 2537
    • (2006) Eur Heart J , vol.27 , pp. 2530-2537
    • Mor, A.1    Luboshits, G.2    Planer, D.3    Keren, G.4    George, J.5
  • 165
    • 79960700561 scopus 로고    scopus 로고
    • Activation of Th17/Th1 and Th1, but not Th17, is associated with the acute cardiac event in patients with acute coronary syndrome
    • Z. Zhao, Y. Wu, and M. Cheng Activation of Th17/Th1 and Th1, but not Th17, is associated with the acute cardiac event in patients with acute coronary syndrome Atherosclerosis 217 2011 518 524
    • (2011) Atherosclerosis , vol.217 , pp. 518-524
    • Zhao, Z.1    Wu, Y.2    Cheng, M.3
  • 166
    • 36348967350 scopus 로고    scopus 로고
    • Low numbers of FOXP3 positive regulatory T cells are present in all developmental stages of human atherosclerotic lesions
    • O.J. de Boer, J.J. van der Meer, P. Teeling, C.M. van der Loos, and A.C. van der Wal Low numbers of FOXP3 positive regulatory T cells are present in all developmental stages of human atherosclerotic lesions PLoS One 2 2007 e779
    • (2007) PLoS One , vol.2 , pp. 779
    • De Boer, O.J.1    Van Der Meer, J.J.2    Teeling, P.3    Van Der Loos, C.M.4    Van Der Wal, A.C.5
  • 167
    • 78650025765 scopus 로고    scopus 로고
    • The "atheroprotective" mediators apolipoprotein A-I and Foxp3 are over-abundant in unstable carotid plaques
    • S. Patel, S.H. Chung, G. White, S. Bao, and D.S. Celermajer The "atheroprotective" mediators apolipoprotein A-I and Foxp3 are over-abundant in unstable carotid plaques Int J Cardiol 145 2010 183 187
    • (2010) Int J Cardiol , vol.145 , pp. 183-187
    • Patel, S.1    Chung, S.H.2    White, G.3    Bao, S.4    Celermajer, D.S.5
  • 168
    • 77955983228 scopus 로고    scopus 로고
    • Circulating CD4+CD25hiCD127lo regulatory T-cell levels do not reflect the extent or severity of carotid and coronary atherosclerosis
    • E. Ammirati, D. Cianflone, and M. Banfi Circulating CD4+CD25hiCD127lo regulatory T-cell levels do not reflect the extent or severity of carotid and coronary atherosclerosis Arterioscler Thromb Vasc Biol 30 2010 1832 1841
    • (2010) Arterioscler Thromb Vasc Biol , vol.30 , pp. 1832-1841
    • Ammirati, E.1    Cianflone, D.2    Banfi, M.3
  • 169
    • 84879420439 scopus 로고    scopus 로고
    • FOXP3 demethylation as a means of identifying quantitative defects in regulatory T cells in acute coronary syndrome
    • C.X. Lu, R.D. Xu, and M. Cao FOXP3 demethylation as a means of identifying quantitative defects in regulatory T cells in acute coronary syndrome Atherosclerosis 229 2013 263 270
    • (2013) Atherosclerosis , vol.229 , pp. 263-270
    • Lu, C.X.1    Xu, R.D.2    Cao, M.3
  • 170
    • 1642415712 scopus 로고    scopus 로고
    • Histone deacetylase inhibitor suberoylanilide hydroxamic acid reduces acute graft-versus-host disease and preserves graft-versus-leukemia effect
    • P. Reddy, Y. Maeda, and K. Hotary Histone deacetylase inhibitor suberoylanilide hydroxamic acid reduces acute graft-versus-host disease and preserves graft-versus-leukemia effect Proc Natl Acad Sci U S A 101 2004 3921 3926
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 3921-3926
    • Reddy, P.1    Maeda, Y.2    Hotary, K.3
  • 171
    • 84892379541 scopus 로고    scopus 로고
    • Immune effectors required for the therapeutic activity of vorinostat
    • O. Kepp, L. Galluzzi, and G. Kroemer Immune effectors required for the therapeutic activity of vorinostat Oncoimmunology 2 2013 e27157
    • (2013) Oncoimmunology , vol.2 , pp. 27157
    • Kepp, O.1    Galluzzi, L.2    Kroemer, G.3
  • 172
    • 36148950997 scopus 로고    scopus 로고
    • FDA approval summary: Vorinostat for treatment of advanced primary cutaneous T-cell lymphoma
    • B.S. Mann, J.R. Johnson, M.H. Cohen, R. Justice, and R. Pazdur FDA approval summary: vorinostat for treatment of advanced primary cutaneous T-cell lymphoma Oncologist 12 2007 1247 1252
    • (2007) Oncologist , vol.12 , pp. 1247-1252
    • Mann, B.S.1    Johnson, J.R.2    Cohen, M.H.3    Justice, R.4    Pazdur, R.5
  • 173
    • 34247607092 scopus 로고    scopus 로고
    • Results of a phase II trial of oral bexarotene (targretin) combined with interferon alfa-2b (intron-A) for patients with cutaneous T-cell lymphoma
    • D.J. Straus, M. Duvic, T. Kuzel, and S. Horwitz Results of a phase II trial of oral bexarotene (targretin) combined with interferon alfa-2b (intron-A) for patients with cutaneous T-cell lymphoma Cancer 109 2007 1799 1803
    • (2007) Cancer , vol.109 , pp. 1799-1803
    • Straus, D.J.1    Duvic, M.2    Kuzel, T.3    Horwitz, S.4
  • 174
    • 33749684290 scopus 로고    scopus 로고
    • A phase II open-label study of recombinant human interleukin-12 in patients with stage IA, IB, or IIA mycosis fungoides
    • M. Duvic, M.L. Sherman, and G.S. Wood A phase II open-label study of recombinant human interleukin-12 in patients with stage IA, IB, or IIA mycosis fungoides J Am Acad Dermatol 55 2006 807 813
    • (2006) J Am Acad Dermatol , vol.55 , pp. 807-813
    • Duvic, M.1    Sherman, M.L.2    Wood, G.S.3
  • 175
    • 79955552937 scopus 로고    scopus 로고
    • Safety and efficacy of an oral histone deacetylase inhibitor in systemic-onset juvenile idiopathic arthritis
    • J. Vojinovic, N. Damjanov, and C. D'Urzo Safety and efficacy of an oral histone deacetylase inhibitor in systemic-onset juvenile idiopathic arthritis Arthritis Rheum 63 2011 1452 1458
    • (2011) Arthritis Rheum , vol.63 , pp. 1452-1458
    • Vojinovic, J.1    Damjanov, N.2    D'Urzo, C.3
  • 176
    • 35948980739 scopus 로고    scopus 로고
    • Deacetylase inhibition promotes the generation and function of regulatory T cells
    • R. Tao, E.F. de Zoeten, and E. Ozkaynak Deacetylase inhibition promotes the generation and function of regulatory T cells Nat Med 13 2007 1299 1307
    • (2007) Nat Med , vol.13 , pp. 1299-1307
    • Tao, R.1    De Zoeten, E.F.2    Ozkaynak, E.3
  • 177
    • 84878719586 scopus 로고    scopus 로고
    • Trichostatin A promotes the generation and suppressive functions of regulatory T cells
    • C. Donas, M. Fritz, and V. Manriquez Trichostatin A promotes the generation and suppressive functions of regulatory T cells Clin Dev Immunol 2013 2013 679804
    • (2013) Clin Dev Immunol , vol.2013 , pp. 679804
    • Donas, C.1    Fritz, M.2    Manriquez, V.3
  • 178
    • 0037330279 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors modulate renal disease in the MRL-lpr/lpr mouse
    • N. Mishra, C.M. Reilly, D.R. Brown, P. Ruiz, and G.S. Gilkeson Histone deacetylase inhibitors modulate renal disease in the MRL-lpr/lpr mouse J Clin Invest 111 2003 539 552
    • (2003) J Clin Invest , vol.111 , pp. 539-552
    • Mishra, N.1    Reilly, C.M.2    Brown, D.R.3    Ruiz, P.4    Gilkeson, G.S.5
  • 179
    • 84857233842 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors suppress rheumatoid arthritis fibroblast-like synoviocyte and macrophage IL-6 production by accelerating mRNA decay
    • A.M. Grabiec, O. Korchynskyi, P.P. Tak, and K.A. Reedquist Histone deacetylase inhibitors suppress rheumatoid arthritis fibroblast-like synoviocyte and macrophage IL-6 production by accelerating mRNA decay Ann Rheum Dis 71 2012 424 431
    • (2012) Ann Rheum Dis , vol.71 , pp. 424-431
    • Grabiec, A.M.1    Korchynskyi, O.2    Tak, P.P.3    Reedquist, K.A.4
  • 180
    • 52249094653 scopus 로고    scopus 로고
    • Upregulated miR-146a expression in peripheral blood mononuclear cells from rheumatoid arthritis patients
    • K.M. Pauley, M. Satoh, A.L. Chan, M.R. Bubb, W.H. Reeves, and E.K. Chan Upregulated miR-146a expression in peripheral blood mononuclear cells from rheumatoid arthritis patients Arthritis Res Ther 10 2008 R101
    • (2008) Arthritis Res Ther , vol.10 , pp. 101
    • Pauley, K.M.1    Satoh, M.2    Chan, A.L.3    Bubb, M.R.4    Reeves, W.H.5    Chan, E.K.6
  • 181
    • 0035806290 scopus 로고    scopus 로고
    • Identification and functional characterization of human CD4(+)CD25(+) T cells with regulatory properties isolated from peripheral blood
    • H. Jonuleit, E. Schmitt, M. Stassen, A. Tuettenberg, J. Knop, and A.H. Enk Identification and functional characterization of human CD4(+)CD25(+) T cells with regulatory properties isolated from peripheral blood J Exp Med 193 2001 1285 1294
    • (2001) J Exp Med , vol.193 , pp. 1285-1294
    • Jonuleit, H.1    Schmitt, E.2    Stassen, M.3    Tuettenberg, A.4    Knop, J.5    Enk, A.H.6
  • 182
    • 0035546070 scopus 로고    scopus 로고
    • CD4(+) regulatory T cells
    • S. Read, and F. Powrie CD4(+) regulatory T cells Curr Opin Immunol 13 2001 644 649
    • (2001) Curr Opin Immunol , vol.13 , pp. 644-649
    • Read, S.1    Powrie, F.2
  • 183
    • 39749142196 scopus 로고    scopus 로고
    • Enhanced functionality of CD4+CD25(high)FoxP3+ regulatory T cells in the peripheral blood of patients with prostate cancer
    • J. Yokokawa, V. Cereda, and C. Remondo Enhanced functionality of CD4+CD25(high)FoxP3+ regulatory T cells in the peripheral blood of patients with prostate cancer Clin Cancer Res 14 2008 1032 1040
    • (2008) Clin Cancer Res , vol.14 , pp. 1032-1040
    • Yokokawa, J.1    Cereda, V.2    Remondo, C.3
  • 184
    • 0036721629 scopus 로고    scopus 로고
    • Prevalence of regulatory T cells is increased in peripheral blood and tumor microenvironment of patients with pancreas or breast adenocarcinoma
    • U.K. Liyanage, T.T. Moore, and H.G. Joo Prevalence of regulatory T cells is increased in peripheral blood and tumor microenvironment of patients with pancreas or breast adenocarcinoma J Immunol 169 2002 2756 2761
    • (2002) J Immunol , vol.169 , pp. 2756-2761
    • Liyanage, U.K.1    Moore, T.T.2    Joo, H.G.3
  • 185
    • 30144444279 scopus 로고    scopus 로고
    • Enhancement of vaccine-mediated antitumor immunity in cancer patients after depletion of regulatory T cells
    • J. Dannull, Z. Su, and D. Rizzieri Enhancement of vaccine-mediated antitumor immunity in cancer patients after depletion of regulatory T cells J Clin Invest 115 2005 3623 3633
    • (2005) J Clin Invest , vol.115 , pp. 3623-3633
    • Dannull, J.1    Su, Z.2    Rizzieri, D.3
  • 186
    • 30744458573 scopus 로고    scopus 로고
    • Lymphopenia and interleukin-2 therapy alter homeostasis of CD4+CD25+ regulatory T cells
    • H. Zhang, K.S. Chua, and M. Guimond Lymphopenia and interleukin-2 therapy alter homeostasis of CD4+CD25+ regulatory T cells Nat Med 11 2005 1238 1243
    • (2005) Nat Med , vol.11 , pp. 1238-1243
    • Zhang, H.1    Chua, K.S.2    Guimond, M.3
  • 187
    • 0025345935 scopus 로고
    • High-dose recombinant interleukin-2 alone: A regimen with limited activity in the treatment of advanced renal cell carcinoma
    • J.S. Abrams, A.A. Rayner, and P.H. Wiernik High-dose recombinant interleukin-2 alone: a regimen with limited activity in the treatment of advanced renal cell carcinoma J Natl Cancer Inst 82 1990 1202 1206
    • (1990) J Natl Cancer Inst , vol.82 , pp. 1202-1206
    • Abrams, J.S.1    Rayner, A.A.2    Wiernik, P.H.3
  • 188
    • 7144227930 scopus 로고    scopus 로고
    • Recombinant human interleukin-2, recombinant human interferon alfa-2a, or both in metastatic renal-cell carcinoma. Groupe Francais d'Immunotherapie
    • S. Negrier, B. Escudier, and C. Lasset Recombinant human interleukin-2, recombinant human interferon alfa-2a, or both in metastatic renal-cell carcinoma. Groupe Francais d'Immunotherapie N Engl J Med 338 1998 1272 1278
    • (1998) N Engl J Med , vol.338 , pp. 1272-1278
    • Negrier, S.1    Escudier, B.2    Lasset, C.3
  • 189
    • 28644447974 scopus 로고    scopus 로고
    • Regulatory T cells in ovarian cancer: Biology and therapeutic potential
    • B. Barnett, I. Kryczek, P. Cheng, W. Zou, and T.J. Curiel Regulatory T cells in ovarian cancer: biology and therapeutic potential Am J Reprod Immunol 54 2005 369 377
    • (2005) Am J Reprod Immunol , vol.54 , pp. 369-377
    • Barnett, B.1    Kryczek, I.2    Cheng, P.3    Zou, W.4    Curiel, T.J.5
  • 190
    • 84856403025 scopus 로고    scopus 로고
    • Class i histone deacetylase inhibitor entinostat suppresses regulatory T cells and enhances immunotherapies in renal and prostate cancer models
    • L. Shen, M. Ciesielski, and S. Ramakrishnan Class I histone deacetylase inhibitor entinostat suppresses regulatory T cells and enhances immunotherapies in renal and prostate cancer models PLoS One 7 2012 e30815
    • (2012) PLoS One , vol.7 , pp. 30815
    • Shen, L.1    Ciesielski, M.2    Ramakrishnan, S.3
  • 191
    • 84886943464 scopus 로고    scopus 로고
    • Class i histone deacetylase inhibition is a novel mechanism to target regulatory T cells in immunotherapy
    • L. Shen, and R. Pili Class I histone deacetylase inhibition is a novel mechanism to target regulatory T cells in immunotherapy Oncoimmunology 1 2012 948 950
    • (2012) Oncoimmunology , vol.1 , pp. 948-950
    • Shen, L.1    Pili, R.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.