A critical role for Dnmt1 and DNA methylation in T cell development, function, and survival

Immunity

Volumn 15, Issue 5, 2001, Pages 763-774

  Lee, Peggy P ^a   Fitzpatrick, David R ^c   Beard, Caroline ^d   Jessup, Heidi K ^a   Lehar, Sophie ^a   Makar, Karen W ^a   Pérez Melgosa, Mercedes ^a   Sweetser, Marianne T ^b   Schlissel, Mark S ^e   Nguyen, Suzanne ^d   Cherry, Sara R ^d   Tsai, Jeff H ^a   Tucker, Sean M ^a   Weaver, William M ^a   Kelso, Anne ^c   Jaenisch, Rudolf ^d   Wilson, Christopher B ^a,b  

^a Department of Immunology ^*  (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF QUEENSLAND   (Australia)

^d WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; DNA METHYLTRANSFERASE; MESSENGER RNA;

ANIMAL CELL; ARTICLE; CELL MATURATION; CELL PROLIFERATION; CELL SURVIVAL; DNA METHYLATION; ENZYME ACTIVITY; ENZYME INACTIVATION; GENE EXPRESSION; GENETIC REGULATION; LYMPHOCYTE FUNCTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; T LYMPHOCYTE; THYMOCYTE;

EID: 18244365863     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-7613(01)00227-8     Document Type: Article

References (58)

1. Modulation of chromatin structure regulates cytokine gene expression during T cell differentiation
2. Cell-type-restricted binding of the transcription factor NFAT to a distal IL-4 enhancer in vivo
3. Histone acetylation determines the developmentally regulated accessibility for T cell receptor γ gene recombination
4. Inhibition of T-cell receptor beta-chain gene rearrangement by overexpression of the non-receptor protein tyrosine kinase p56lck
5. Distinct antigen receptor repertoires of two classes of murine epithelium-associated T cells
6. Stability and commitment in T helper cell development
7. Loss of methylation activates Xist in somatic but not in embryonic cells
8. Molecular determinants of TCR expression and selection
9. Methylation-induced repression-belts, braces, and chromatin
10. Helper T cell differentiation is controlled by the cell cycle
11. Demethylated CD8 gene in CD4+ T cells suggests that CD4+ T cells develop from CD8+ precursors
12. Developmental regulation of immune system gene rearrangement
13. BCL-XL-regulated apoptosis in T cell development
14. V(D)J recombination is not activated by demethylation of the kappa locus
15. Interleukin 7 receptor control of T cell receptor γ gene rearrangement: Role of receptor-associated chains and locus accessibility
16. The regulation of CD4 and CD8 coreceptor gene expression during T cell development
17. Hypomethylation is necessary but not sufficient for V(D)J recombination within a transgenic substrate
18. DNA hypomethylation perturbs the function and survival of CNS neurons in postnatal animals
19. high CD8+ T cells
20. Cutting edge: Stable epigenetic inheritance of regional interferon-γ promoter demethylation in CD44high CD8+ T lymphocytes
21. Dnmt3a binds deacetylases and is recruited by a sequence-specific repressor to silence transcription
22. Disruption of thymocyte development and lymphomagenesis induced by SV40 T-antigen
23. Cell division regulates the T cell cytokine repertoire, revealing a mechanism underlying immune class regulation
24. Rapid quantitation of methylation differences at specific sites using methylation-sensitive single nucleotide primer extension (Ms-SNuPE)
25. Early transcription and silencing of cytokine genes underlie polarization of T helper cell subsets
26. Distinct methylation states of the CD8 beta gene in peripheral T cells and intraepithelial lymphocytes
27. Regulation of expression of IL-4 alleles: Analysis using a chimeric GFP/IL-4 gene
28. Loss of genomic methylation causes p53-dependent apoptosis and epigenetic deregulation
29. DNA methylation and imprinting. Why bother?
30. The developmental fate of T cells is critically influenced by TCRγδ expression
31. Long-term hepatic adenovirus-mediated gene expression in mice following CTLA4Ig administration
32. Development and selection of T cells: Facts and puzzles
33. V(D)J recombination becomes accessible
34. T cell development in TCR beta enhancer-deleted mice: Implications for alpha beta T cell lineage commitment and differentiation
35. GATA-3 induces T helper cell type 2 (Th2) cytokine expression and chromatin remodeling in committed Th1 cells
36. Regulation of IL-4 gene expression by distal regulatory elements and GATA-3 at the chromatin level
37. De novo DNA cytosine methyltransferase activities in mouse embryonic stem cells
38. Targeted mutation of the DNA methyltransferase gene results in embryonic lethality
39. A role for histone acetylation in the developmental regulation of V(D)J recombination
40. Hypomethylation of the interferon-gamma gene correlates with its expression by primary T-lineage cells
41. Cloning and characterization of a family of novel mammalian DNA (cytosine-5) methyltransferases
42. Stat6-independent GATA-3 autoactivation directs IL-4-independent Th2 development and commitment
43. Cell expansion and growth arrest phases during the transition from precursor (CD4-8-) to immature (CD4+8+) thymocytes in normal and genetically modified mice
44. Dealing from the evolutionary pawnshop: How lymphocytes make decisions
45. Instruction for cytokine expression in T helper lymphocytes in relation to proliferation and cell cycle progression
46. DNMT1 forms a complex with Rb, E2F1 and HDAC1 and represses transcription from E2F-responsive promoters
47. DNMT1 binds HDAC2 and a new co-repressor, DMAP-1, to form a complex at replication foci
48. A lineage-specific transcriptional silencer regulates CD4 gene expression during T lymphocyte development
49. The interleukin 7 receptor is required for T cell receptor gamma locus accessibility to the V(D)J recombinase
50. Accessibility control of antigen-receptor variable-region gene assembly: Role of cis-acting elements
51. The roles of nuclear factor of activated T cells and ying-yang 1 in activation-induced expression of the interferon-gamma promoter in T cells
52. Lifespan of gamma/delta T cells
53. Pleitropic changes controlled by the pre-T-cell receptor
54. Transcription of IAP endogenous retroviruses is constrained by cytosine methylation
55. Chromatin remodeling of the interleukin-2 gene: Distinct alterations in the proximal versus distal enhancer regions
56. Bisulfite sequencing in preimplantation embryos: DNA methylation profile of the upstream region of the mouse imprinted H19 gene
57. Deletion of germline promoter PD beta 1 from the TCR beta locus causes hypermethylation that impairs D beta 1 recombination by multiple mechanisms
58. Differentiation of the T helper phenotypes by analysis of the methylation state of the IFN-gamma gene