Intracellular protein degradation: From a vague idea thru the lysosome and the ubiquitin-proteasome system and onto human diseases and drug targeting

Cell Death and Differentiation

Volumn 12, Issue 9, 2005, Pages 1178-1190

  Cichanover, Aaron ^a  

^a TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

Author keywords

Lysosome; Proteasome; Protein degradation; Ubiquitin

Indexed keywords

ADENOSINE TRIPHOSPHATE; AMMONIUM CHLORIDE; CELL PROTEIN; CHLOROQUINE; GLOBIN; HEMOGLOBIN; LASALOCID; PROTEASOME; PROTEASOME INHIBITOR; PROTEIN MDM2; PROTEIN P53; PROTEIN SYNTHESIS INHIBITOR; PROTEINASE; TRANSCRIPTION FACTOR; TUMOR SUPPRESSOR PROTEIN; TYROSINE AMINOTRANSFERASE; UBIQUITIN; UBIQUITIN PROTEIN LIGASE E3;

APOPTOSIS; AUTOPHAGY; BINDING AFFINITY; CELL ACTIVATION; CELL CYCLE; CELL DIFFERENTIATION; CELL DIVISION; CELL FUNCTION; CELL GROWTH; DEGENERATIVE DISEASE; DRUG TARGETING; ENDOCYTOSIS; ENZYME ANALYSIS; ENZYME PURIFICATION; GENE MUTATION; HALF LIFE TIME; HEMOGLOBINOPATHY; HUMAN; IMMUNE RESPONSE; LYSOSOME; MALIGNANT NEOPLASTIC DISEASE; NONHUMAN; PATHOGENESIS; PINOCYTOSIS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN MODIFICATION; PROTEIN PROCESSING; PROTEIN STABILITY; PROTEIN SYNTHESIS; RETICULOCYTE; REVIEW; RNA TRANSLATION; SIGNAL TRANSDUCTION; THALASSEMIA; TRANSCRIPTION REGULATION; UBIQUITINATION;

ADENOSINE TRIPHOSPHATE; ANIMALS; BIOCHEMISTRY; CELL CYCLE; CYSTEINE ENDOPEPTIDASES; HISTORY, 20TH CENTURY; HUMANS; LYSOSOMES; MODELS, BIOLOGICAL; PC12 CELLS; PROTEASOME ENDOPEPTIDASE COMPLEX; RATS; RNA; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; UBIQUITIN;

EID: 23944474593     PISSN: 13509047     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.cdd.4401692     Document Type: Review

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