Th 17 cells interplay with Foxp3+ Tregs in regulation of inflammation and autoimmunity

Frontiers in Bioscience

Volumn 15, Issue 3, 2010, Pages 986-1006

  Mai, Jietang ^a   Wang, Hong ^a   Yang, Xiao Feng ^a  

^a TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Autoimmune diseases; Il 17; Inflammation; Interleukin 17; Review; Th17; Tregs

Indexed keywords

CYTOKINE; FORKHEAD TRANSCRIPTION FACTOR; FOXP3 PROTEIN, HUMAN; INTERLEUKIN 17;

ANIMAL; AUTOIMMUNE DISEASE; AUTOIMMUNITY; HELPER CELL; HUMAN; IMMUNOLOGY; INFLAMMATION; METABOLISM; REGULATORY T LYMPHOCYTE; REVIEW;

ANIMALS; AUTOIMMUNE DISEASES; AUTOIMMUNITY; CYTOKINES; FORKHEAD TRANSCRIPTION FACTORS; HUMANS; INFLAMMATION; INTERLEUKIN-17; T-LYMPHOCYTES, HELPER-INDUCER; T-LYMPHOCYTES, REGULATORY;

EID: 77956645431     PISSN: 27686701     EISSN: 27686698     Source Type: Journal    
DOI: 10.2741/3657     Document Type: Article

References (180)

1. Korn, T., E. Bettelli, M. Oukka & V. K. Kuchroo: IL-17 and Th17 Cells. Annu Rev Immunol, 27, 485-517 (2009).
2. Hue, S., P. Ahern, S. Buonocore, M. C. Kullberg, D. J. Cua, B. S. McKenzie, F. Powrie & K. J. Maloy: Interleukin-23 drives innate and T cell-mediated intestinal inflammation. J Exp Med, 203, 2473-83 (2006). (Pubitemid 44664617)
3. Fujino, S., A. Andoh, S. Bamba, A. Ogawa, K. Hata, Y. Araki, T. Bamba & Y. Fujiyama: Increased expression of interleukin 17 in inflammatory bowel disease. Gut, 52, 65-70 (2003). (Pubitemid 36020767)
4. Csiszar, A., Z. Ungvari, A. Koller, J. G. Edwards & G. Kaley: Aging-induced proinflammatory shift in cytokine expression profile in coronary arteries. Faseb J, 17, 1183-5 (2003).
5. de Boer, O. J., J. J. van der Meer, P. Teeling, C. M. van der Loos, M. M. Idu, F. van Maldegem, J. Aten & A. C. van der Wal: Differential expression of interleukin-17 family cytokines in intact and complicated human atherosclerotic plaques. J pathol. (2009).
6. Rao, D. A., R. E. Eid, L. Qin, T. Yi, N. C. Kirkiles- Smith, G. Tellides & J. S. Pober: Interleukin (IL)-1 promotes allogeneic T cell intimal infiltration and IL-17 production in a model of human artery rejection. J Exp Med, 205, 3145-58 (2008).
7. Jones, C. E. & K. Chan: Interleukin-17 stimulates the expression of interleukin-8, growth-related oncogene-alpha, and granulocyte-colony-stimulating factor by human airway epithelial cells. Am J Respir Cell Mol Biol, 26, 748-53 (2002). (Pubitemid 34557377)
8. Amadi-Obi, A., C. R. Yu, X. Liu, R. M. Mahdi, G. L. Clarke, R. B. Nussenblatt, I. Gery, Y. S. Lee & C. E. Egwuagu: TH17 cells contribute to uveitis and scleritis and are expanded by IL-2 and inhibited by IL-27/STAT1. Nat Med, 13, 711-8 (2007). (Pubitemid 46889754)
9. Kotake, S. & N. Kamatani: The Role of IL-17 in Joint Destruction. Drug News Perspect, 15, 17-23 (2002). (Pubitemid 34262942)
10. Paradowska, A., W. Masliniski, A. Grzybowska- Kowalczyk & J. Lacki: The function of interleukin 17 in the pathogenesis of rheumatoid arthritis. Arch Immunol Ther Exp (Warsz), 55, 329-34 (2007).
11. Komiyama, Y., S. Nakae, T. Matsuki, A. Nambu, H. Ishigame, S. Kakuta, K. Sudo & Y. Iwakura: IL-17 plays an important role in the development of experimental autoimmune encephalomyelitis. J Immunol, 177, 566-73 (2006). (Pubitemid 43939170)
12. Zhang, Z., M. Zheng, J. Bindas, P. Schwarzenberger & J. K. Kolls: Critical role of IL-17 receptor signaling in acute TNBS-induced colitis. Inflamm Bowel Dis, 12, 382-8 (2006).
13. Ogawa, A., A. Andoh, Y. Araki, T. Bamba & Y. Fujiyama: Neutralization of interleukin-17 aggravates dextran sulfate sodium-induced colitis in mice. Clin Immunol, 110, 55-62 (2004). (Pubitemid 38177420)
14. Emamaullee, J. A., J. Davis, S. Merani, C. Toso, J. F. Elliott, A. Thiesen & A. M. Shapiro: Inhibition of Th17 cells regulates autoimmune diabetes in NOD mice. Diabetes, 58, 1302-11 (2009).
15. Bending, D., H. De La Pena, M. Veldhoen, J. M. Phillips, C. Uyttenhove, B. Stockinger & A. Cooke: Highly purified Th17 cells from BDC2.5NOD mice convert into Th1-like cells in NOD/SCID recipient mice. J Clin Invest (2009).
16. Fazilleau, N., L. Mark, L. J. McHeyzer-Williams & M. G. McHeyzer-Williams: Follicular helper T cells: lineage and location. Immunity, 30, 324-35 (2009).
17. King, C.: New insights into the differentiation and function of T follicular helper cells. Nat Rev Immunol, 9, 757-66 (2009).
18. Veldhoen, M., C. Uyttenhove, J. van Snick, H. Helmby, A. Westendorf, J. Buer, B. Martin, C. Wilhelm & B. Stockinger: Transforming growth factor-beta 'reprograms' the differentiation of T helper 2 cells and promotes an interleukin 9-producing subset. Nat Immunol, 9, 1341-6 (2008).
19. Dardalhon, V., A. Awasthi, H. Kwon, G. Galileos, W. Gao, R. A. Sobel, M. Mitsdoerffer, T. B. Strom, W. Elyaman, I. C. Ho, S. Khoury, M. Oukka & V. K. Kuchroo: IL-4 inhibits TGF-beta-induced Foxp3+ T cells and, together with TGF-beta, generates IL-9+ IL-10+ Foxp3 (-) effector T cells. Nat Immunol, 9, 1347-55 (2008).
20. Soroosh, P. & T. A. Doherty: Th9 and allergic disease. Immunology, 127, 450-8 (2009).
21. Yang, X. F.: Factors regulating apoptosis and homeostasis of CD4+CD25highFOXP3+ regulatory T cells are new therapeutic targets. Front Biosci, 13, 1472-99 (2008).
22. Ke, X. Y., J. Wang, L. Li, I. H. Chen, H. Wang & X. F. Yang: Roles of CD4+CD25high FOXP3+ Tregs in lymphomas and tumors are complex. Front Biosci, 13, 3986-4001 (2008). (Pubitemid 351594676)
23. Mosmann, T. R. & R. L. Coffman: TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu Rev Immunol, 7, 145-73 (1989). (Pubitemid 19138011)
24. Basso, A. S., H. Cheroutre & D. Mucida: More stories on Th17 cells. Cell Res, 19, 399-411 (2009).
25. Sallusto, F., C. R. Mackay & A. Lanzavecchia: Selective expression of the eotaxin receptor CCR3 by human T helper 2 cells. Science, 277, 2005-7 (1997). (Pubitemid 27449145)
26. Bonecchi, R., G. Bianchi, P. P. Bordignon, D. D'Ambrosio, R. Lang, A. Borsatti, S. Sozzani, P. Allavena, P. A. Gray, A. Mantovani & F. Sinigaglia: Differential expression of chemokine receptors and chemotactic responsiveness of type 1 T helper cells (Th1s) and Th2s. J Exp Med, 187, 129-34 (1998). (Pubitemid 28044828)
27. Lohmann, T., S. Laue, U. Nietzschmann, T. M. Kapellen, I. Lehmann, S. Schroeder, R. Paschke & W. Kiess: Reduced expression of Th1-associated chemokine receptors on peripheral blood lymphocytes at diagnosis of type 1 diabetes. Diabetes, 51, 2474-80 (2002). (Pubitemid 34827396)
28. Okazaki, H., M. Kakurai, D. Hirata, H. Sato, T. Kamimura, N. Onai, K. Matsushima, H. Nakagawa, S. Kano & S. Minota: Characterization of chemokine receptor expression and cytokine production in circulating CD4+ T cells from patients with atopic dermatitis: up-regulation of C-C chemokine receptor 4 in atopic dermatitis. Clin Exp Allergy, 32, 1236-42 (2002). (Pubitemid 35007430)
29. Anthony, R. M., L. I. Rutitzky, J. F. Urban, Jr., M. J. Stadecker & W. C. Gause: Protective immune mechanisms in helminth infection. Nat Rev Immunol, 7, 975-87 (2007). (Pubitemid 350166058)
30. Krakowski, M. & T. Owens: Interferon-gamma confers resistance to experimental allergic encephalomyelitis. Eur J Immunol, 26, 1641-6 (1996). (Pubitemid 26230015)
31. Tran, E. H., E. N. Prince & T. Owens: IFN-gamma shapes immune invasion of the central nervous system via regulation of chemokines. J Immunol, 164, 2759-68 (2000). (Pubitemid 30115510)
32. Oppmann, B., R. Lesley, B. Blom, J. C. Timans, Y. Xu, B. Hunte, F. Vega, N. Yu, J. Wang, K. Singh, F. Zonin, E. Vaisberg, T. Churakova, M. Liu, D. Gorman, J. Wagner, S. Zurawski, Y. Liu, J. S. Abrams, K. W. Moore, D. Rennick, R. de Waal-Malefyt, C. Hannum, J. F. Bazan & R. A. Kastelein: Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. Immunity, 13, 715-25 (2000).
33. Cua, D. J., J. Sherlock, Y. Chen, C. A. Murphy, B. Joyce, B. Seymour, L. Lucian, W. To, S. Kwan, T. Churakova, S. Zurawski, M. Wiekowski, S. A. Lira, D. Gorman, R. A. Kastelein & J. D. Sedgwick: Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain. Nature, 421, 744-8 (2003). (Pubitemid 36227625)
34. Sakaguchi, S. & F. Powrie: Emerging challenges in regulatory T cell function and biology. Science, 317, 627-9 (2007). (Pubitemid 47229955)
35. Shevach, E. M., R. A. DiPaolo, J. Andersson, D. M. Zhao, G. L. Stephens & A. M. Thornton: The lifestyle of naturally occurring CD4+ CD25+ Foxp3+ regulatory T cells. Immunol Rev, 212, 60-73 (2006). (Pubitemid 44116700)
36. Yang, X. F., Y. Yin & H. Wang: VASCULAR INFLAMMATION AND ATHEROGENESIS ARE ACTIVATED VIA RECEPTORS FOR PAMPs AND SUPPRESSED BY REGULATORY T CELLS. Drug Discov Today Ther Strateg, 5, 125-142 (2008).
37. Annunziato, F., L. Cosmi, V. Santarlasci, L. Maggi, F. Liotta, B. Mazzinghi, E. Parente, L. Fili, S. Ferri, F. Frosali, F. Giudici, P. Romagnani, P. Parronchi, F. Tonelli, E. Maggi & S. Romagnani: Phenotypic and functional features of human Th17 cells. J Exp Med, 204, 1849-61 (2007). (Pubitemid 47240944)
38. Cosmi, L., R. De Palma, V. Santarlasci, L. Maggi, M. Capone, F. Frosali, G. Rodolico, V. Querci, G. Abbate, R. Angeli, L. Berrino, M. Fambrini, M. Caproni, F. Tonelli, E. Lazzeri, P. Parronchi, F. Liotta, E. Maggi, S. Romagnani & F. Annunziato: Human interleukin 17-producing cells originate from a CD161+CD4+ T cell precursor. J Exp Med, 205, 1903-16 (2008).
39. Acosta-Rodriguez, E. V., L. Rivino, J. Geginat, D. Jarrossay, M. Gattorno, A. Lanzavecchia, F. Sallusto & G. Napolitani: Surface phenotype and antigenic specificity of human interleukin 17-producing T helper memory cells. Nat Immunol, 8, 639-46 (2007). (Pubitemid 46785128)
40. Tsuji, M., N. Komatsu, S. Kawamoto, K. Suzuki, O. Kanagawa, T. Honjo, S. Hori & S. Fagarasan: Preferential generation of follicular B helper T cells from Foxp3+ T cells in gut Peyer's patches. Science, 323, 1488-92 (2009).
41. Nurieva, R. I., Y. Chung, D. Hwang, X. O. Yang, H. S. Kang, L. Ma, Y. H. Wang, S. S. Watowich, A. M. Jetten, Q. Tian & C. Dong: Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages. Immunity, 29, 138-49 (2008).
42. Eddahri, F., S. Denanglaire, F. Bureau, R. Spolski, W. J. Leonard, O. Leo & F. Andris: Interleukin-6/STAT3 signaling regulates the ability of naïve T cells to acquire Bcell help capacities. Blood, 113, 2426-33 (2009).
43. Chen, J. & X. S. Liu: Development and function of IL-10 IFN-gamma-secreting CD4 (+) T cells. J Leukoc Biol, 86, 1305-10 (2009).
44. Dumitriu, I. E., E. T. Araguas, C. Baboonian & J. C. Kaski: CD4+ CD28 null T cells in coronary artery disease: when helpers become killers. Cardiovasc Res, 81, 11-9 (2009).
45. Rouvier, E., M. F. Luciani, M. G. Mattei, F. Denizot & P. Golstein: CTLA-8, cloned from an activated T cell, bearing AU-rich messenger RNA instability sequences, and homologous to a herpesvirus saimiri gene. J Immunol, 150, 5445-56 (1993). (Pubitemid 23180658)
46. Yao, Z., S. L. Painter, W. C. Fanslow, D. Ulrich, B. M. Macduff, M. K. Spriggs & R. J. Armitage: Human IL-17: a novel cytokine derived from T cells. J Immunol, 155, 5483-6 (1995).
47. Hymowitz, S. G., E. H. Filvaroff, J. P. Yin, J. Lee, L. Cai, P. Risser, M. Maruoka, W. Mao, J. Foster, R. F. Kelley, G. Pan, A. L. Gurney, A. M. de Vos & M. A. Starovasnik: IL-17s adopt a cystine knot fold: structure and activity of a novel cytokine, IL-17F, and implications for receptor binding. Embo J, 20, 5332-41 (2001). (Pubitemid 32959452)
48. Starnes, T., M. J. Robertson, G. Sledge, S. Kelich, H. Nakshatri, H. E. Broxmeyer & R. Hromas: Cutting edge: IL- 17F, a novel cytokine selectively expressed in activated T cells and monocytes, regulates angiogenesis and endothelial cell cytokine production. J Immunol, 167, 4137-40 (2001). (Pubitemid 32954284)
49. Allison, J., H. Thomas, D. Beck, J. L. Brady, A. M. Lew, A. Elefanty, H. Kosaka, T. W. Kay, D. C. Huang & A. Strasser: Transgenic overexpression of human Bcl-2 in islet beta cells inhibits apoptosis but does not prevent autoimmune destruction. Int Immunol, 12, 9-17. (2000). (Pubitemid 30045407)
50. Lee, J., W. H. Ho, M. Maruoka, R. T. Corpuz, D. T. Baldwin, J. S. Foster, A. D. Goddard, D. G. Yansura, R. L. Vandlen, W. I. Wood & A. L. Gurney: IL-17E, a novel proinflammatory ligand for the IL-17 receptor homolog IL-17Rh1. J Biol Chem, 276, 1660-4 (2001). (Pubitemid 32096603)
51. Wright, J. F., Y. Guo, A. Quazi, D. P. Luxenberg, F. Bennett, J. F. Ross, Y. Qiu, M. J. Whitters, K. N. Tomkinson, K. Dunussi-Joannopoulos, B. M. Carreno, M. Collins & N. M. Wolfman: Identification of an interleukin 17F/17A heterodimer in activated human CD4+ T cells. J Biol Chem, 282, 13447-55 (2007). (Pubitemid 47100510)
52. Chang, S. H. & C. Dong: A novel heterodimeric cytokine consisting of IL-17 and IL-17F regulates inflammatory responses. Cell Res, 17, 435-40 (2007). (Pubitemid 46763094)
53. Liang, S. C., A. J. Long, F. Bennett, M. J. Whitters, R. Karim, M. Collins, S. J. Goldman, K. Dunussi-Joannopoulos, C. M. Williams, J. F. Wright & L. A. Fouser: An IL-17F/A heterodimer protein is produced by mouse Th17 cells and induces airway neutrophil recruitment. J Immunol, 179, 7791-9 (2007).
54. Ferretti, S., O. Bonneau, G. R. Dubois, C. E. Jones & A. Trifilieff: IL-17, produced by lymphocytes and neutrophils, is necessary for lipopolysaccharide-induced airway neutrophilia: IL-15 as a possible trigger. J Immunol, 170, 2106-12 (2003). (Pubitemid 36197433)
55. Lockhart, E., A. M. Green & J. L. Flynn: IL-17 production is dominated by gammadelta T cells rather than CD4 T cells during Mycobacterium tuberculosis infection. J Immunol, 177, 4662-9 (2006). (Pubitemid 44469799)
56. Aggarwal, S., N. Ghilardi, M. H. Xie, F. J. de Sauvage & A. L. Gurney: Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17. J Biol Chem, 278, 1910-4 (2003). (Pubitemid 36801431)
57. Park, H., Z. Li, X. O. Yang, S. H. Chang, R. Nurieva, Y. H. Wang, Y. Wang, L. Hood, Z. Zhu, Q. Tian & C. Dong: A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat Immunol, 6, 1133-41 (2005). (Pubitemid 41541791)
58. Harrington, L. E., R. D. Hatton, P. R. Mangan, H. Turner, T. L. Murphy, K. M. Murphy & C. T. Weaver: Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat Immunol, 6, 1123-32 (2005). (Pubitemid 41541790)
59. Infante-Duarte, C., H. F. Horton, M. C. Byrne & T. Kamradt: Microbial lipopeptides induce the production of IL-17 in Th cells. J Immunol, 165, 6107-15 (2000).
60. Korn, T., E. Bettelli, W. Gao, A. Awasthi, A. Jager, T. B. Strom, M. Oukka & V. K. Kuchroo: IL-21 initiates an alternative pathway to induce proinflammatory T (H)17 cells. Nature, 448, 484-7 (2007). (Pubitemid 47123515)
61. Langrish, C. L., Y. Chen, W. M. Blumenschein, J. Mattson, B. Basham, J. D. Sedgwick, T. McClanahan, R. A. Kastelein & D. J. Cua: IL-23 drives a pathogenic T cell population that induces autoimmune inflammation. J Exp Med, 201, 233-40 (2005). (Pubitemid 40189432)
62. Liang, S. C., X. Y. Tan, D. P. Luxenberg, R. Karim, K. Dunussi-Joannopoulos, M. Collins & L. A. Fouser: Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides. J Exp Med, 203, 2271-9 (2006). (Pubitemid 44498362)
63. Bettelli, E., Y. Carrier, W. Gao, T. Korn, T. B. Strom, M. Oukka, H. L. Weiner & V. K. Kuchroo: Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature, 441, 235-8 (2006).
64. Korn, T., M. Oukka, V. Kuchroo & E. Bettelli: Th17 cells: effector T cells with inflammatory properties. Semin Immunol, 19, 362-71 (2007). (Pubitemid 351274046)
65. Mangan, P. R., L. E. Harrington, D. B. O'Quinn, W. S. Helms, D. C. Bullard, C. O. Elson, R. D. Hatton, S. M. Wahl, T. R. Schoeb & C. T. Weaver: Transforming growth factor-beta induces development of the T (H)17 lineage. Nature, 441, 231-4 (2006).
66. Nurieva, R., X. O. Yang, G. Martinez, Y. Zhang, A. D. Panopoulos, L. Ma, K. Schluns, Q. Tian, S. S. Watowich, A. M. Jetten & C. Dong: Essential autocrine regulation by IL-21 in the generation of inflammatory T cells. Nature, 448, 480-3 (2007). (Pubitemid 47123514)
67. Veldhoen, M., R. J. Hocking, C. J. Atkins, R. M. Locksley & B. Stockinger: TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity, 24, 179-89 (2006). (Pubitemid 43214587)
68. Zhou, L., Ivanov, II, R. Spolski, R. Min, K. Shenderov, T. Egawa, D. E. Levy, W. J. Leonard & D. R. Littman: IL-6 programs T (H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways. Nat Immunol, 8, 967-74 (2007). (Pubitemid 47300011)
69. Szabo, S. J., B. M. Sullivan, S. L. Peng & L. H. Glimcher: Molecular mechanisms regulating Th1 immune responses. Annu Rev Immunol, 21, 713-58 (2003). (Pubitemid 37174546)
70. Glimcher, L. H. & K. M. Murphy: Lineage commitment in the immune system: the T helper lymphocyte grows up. Genes Dev, 14, 1693-711 (2000). (Pubitemid 30602989)
71. Chen, Y., C. L. Langrish, B. McKenzie, B. Joyce-Shaikh, J. S. Stumhofer, T. McClanahan, W. Blumenschein, T. Churakovsa, J. Low, L. Presta, C. A. Hunter, R. A. Kastelein & D. J. Cua: Anti-IL-23 therapy inhibits multiple inflammatory pathways and ameliorates autoimmune encephalomyelitis. J Clin Invest, 116, 1317-26 (2006).
72. McGeachy, M. J., K. S. Bak-Jensen, Y. Chen, C. M. Tato, W. Blumenschein, T. McClanahan & D. J. Cua: TGFbeta and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain T (H)-17 cell-mediated pathology. Nat Immunol, 8, 1390-7 (2007). (Pubitemid 350138974)
73. Brustle, A., S. Heink, M. Huber, C. Rosenplanter, C. Stadelmann, P. Yu, E. Arpaia, T. W. Mak, T. Kamradt & M. Lohoff: The development of inflammatory T (H)-17 cells requires interferon-regulatory factor 4. Nat Immunol, 8, 958-66 (2007). (Pubitemid 47300010)
74. Schraml, B. U., K. Hildner, W. Ise, W. L. Lee, W. A. Smith, B. Solomon, G. Sahota, J. Sim, R. Mukasa, S. Cemerski, R. D. Hatton, G. D. Stormo, C. T. Weaver, J. H. Russell, T. L. Murphy & K. M. Murphy: The AP-1 transcription factor Batf controls T (H)17 differentiation. Nature, 460, 405-9 (2009).
75. Harris, T. J., J. F. Grosso, H. R. Yen, H. Xin, M. Kortylewski, E. Albesiano, E. L. Hipkiss, D. Getnet, M. V. Goldberg, C. H. Maris, F. Housseau, H. Yu, D. M. Pardoll & C. G. Drake: Cutting edge: An in vivo requirement for STAT3 signaling in TH17 development and TH17- dependent autoimmunity. J Immunol, 179, 4313-7 (2007).
76. Ivanov, II, B. S. McKenzie, L. Zhou, C. E. Tadokoro, A. Lepelley, J. J. Lafaille, D. J. Cua & D. R. Littman: The orphan nuclear receptor RORgamma t directs the differentiation program of proinflammatory IL-17+ T helper cells. Cell, 126, 1121-33 (2006). (Pubitemid 44380299)
77. Wei, L., A. Laurence, K. M. Elias & J. J. O'Shea: IL-21 is produced by Th17 cells and drives IL-17 production in a STAT3-dependent manner. J Biol Chem, 282, 34605-10 (2007). (Pubitemid 350232469)
78. Yang, X. F., P. Fang, S. Meng, M. Jan, X. Xiong, Y. Yin & H. Wang: The FOX transcription factors regulate vascular pathology, diabetes and Tregs. Front Biosci (Schol Ed), 1, 420-36 (2009).
79. Li, M. O., Y. Y. Wan & R. A. Flavell: T cell-produced transforming growth factor-beta1 controls T cell tolerance and regulates Th1- and Th17-cell differentiation. Immunity, 26, 579-91 (2007). (Pubitemid 46756347)
80. Volpe, E., N. Servant, R. Zollinger, S. I. Bogiatzi, P. Hupe, E. Barillot & V. Soumelis: A critical function for transforming growth factor-beta, interleukin 23 and proinflammatory cytokines in driving and modulating human T (H)-17 responses. Nat Immunol, 9, 650-7 (2008). (Pubitemid 351712635)
81. Yang, X. O., R. Nurieva, G. J. Martinez, H. S. Kang, Y. Chung, B. P. Pappu, B. Shah, S. H. Chang, K. S. Schluns, S. S. Watowich, X. H. Feng, A. M. Jetten & C. Dong: Molecular antagonism and plasticity of regulatory and inflammatory T cell programs. Immunity, 29, 44-56 (2008).
82. Acosta-Rodriguez, E. V., G. Napolitani, A. Lanzavecchia & F. Sallusto: Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells. Nat Immunol, 8, 942-9 (2007). (Pubitemid 47300008)
83. Chen, Z., A. Laurence & J. J. O'Shea: Signal transduction pathways and transcriptional regulation in the control of Th17 differentiation. Semin Immunol, 19, 400-8 (2007).
84. Wilson, N. J., K. Boniface, J. R. Chan, B. S. McKenzie, W. M. Blumenschein, J. D. Mattson, B. Basham, K. Smith, T. Chen, F. Morel, J. C. Lecron, R. A. Kastelein, D. J. Cua, T. K. McClanahan, E. P. Bowman & R. de Waal Malefyt: Development, cytokine profile and function of human interleukin 17-producing helper T cells. Nat Immunol, 8, 950-7 (2007). (Pubitemid 47300009)
85. Chen, Y., P. Thai, Y. H. Zhao, Y. S. Ho, M. M. DeSouza & R. Wu: Stimulation of airway mucin gene expression by interleukin (IL)-17 through IL-6 paracrine/autocrine loop. J Biol Chem, 278, 17036-43 (2003). (Pubitemid 36799579)
86. McGeachy, M. J., Y. Chen, C. M. Tato, A. Laurence, B. Joyce-Shaikh, W. M. Blumenschein, T. K. McClanahan, J. J. O'Shea & D. J. Cua: The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17- producing effector T helper cells in vivo. Nat Immunol, 10, 314-24 (2009).
87. Manel, N., D. Unutmaz & D. R. Littman: The differentiation of human T (H)-17 cells requires transforming growth factor-beta and induction of the nuclear receptor RORgamma t. Nat Immunol, 9, 641-9 (2008). (Pubitemid 351714729)
88. Sundrud, M. S., S. B. Koralov, M. Feuerer, D. P. Calado, A. E. Kozhaya, A. Rhule-Smith, R. E. Lefebvre, D. Unutmaz, R. Mazitschek, H. Waldner, M. Whitman, T. Keller & A. Rao: Halofuginone inhibits TH17 cell differentiation by activating the amino acid starvation response. Science, 324, 1334-8 (2009).
89. Lee, W. W., S. W. Kang, J. Choi, S. H. Lee, K. Shah, E. E. Eynon, R. A. Flavell & I. Kang: Regulating human Th17 cells via differential expression of IL-1 receptor. Blood, 115, 530-40.
90. Fossiez, F., O. Djossou, P. Chomarat, L. Flores-Romo, S. Ait-Yahia, C. Maat, J. J. Pin, P. Garrone, E. Garcia, S. Saeland, D. Blanchard, C. Gaillard, B. Das Mahapatra, E. Rouvier, P. Golstein, J. Banchereau & S. Lebecque: T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines. J Exp Med, 183, 2593-603 (1996). (Pubitemid 26193037)
91. Qiu, Z., C. Dillen, J. Hu, H. Verbeke, S. Struyf, J. Van Damme & G. Opdenakker: Interleukin-17 regulates chemokine and gelatinase B expression in fibroblasts to recruit both neutrophils and monocytes. Immunobiology, 214, 835-42 (2009).
92. Bamba, S., A. Andoh, H. Yasui, Y. Araki, T. Bamba & Y. Fujiyama: Matrix metalloproteinase-3 secretion from human colonic subepithelial myofibroblasts: role of interleukin-17. J Gastroenterol, 38, 548-54 (2003). (Pubitemid 36857385)
93. Chabaud, M., P. Garnero, J. M. Dayer, P. A. Guerne, F. Fossiez & P. Miossec: Contribution of interleukin 17 to synovium matrix destruction in rheumatoid arthritis. Cytokine, 12, 1092-9 (2000). (Pubitemid 30479493)
94. Cortez, D. M., M. D. Feldman, S. Mummidi, A. J. Valente, B. Steffensen, M. Vincenti, J. L. Barnes & B. Chandrasekar: IL-17 stimulates MMP-1 expression in primary human cardiac fibroblasts via p38 MAPK- and ERK1/2-dependent C/EBP-beta, NF-kappaB, and AP-1 activation. Am J Physiol Heart Circ Physiol, 293, H3356-65 (2007). (Pubitemid 350230876)
95. Jovanovic, D. V., J. Martel-Pelletier, J. A. Di Battista, F. Mineau, F. C. Jolicoeur, M. Benderdour & J. P. Pelletier: Stimulation of 92-kd gelatinase (matrix metalloproteinase 9) production by interleukin-17 in human monocyte/macrophages: a possible role in rheumatoid arthritis. Arthritis Rheum, 43, 1134-44 (2000). (Pubitemid 30368194)
96. Rifas, L. & S. Arackal: T cells regulate the expression of matrix metalloproteinase in human osteoblasts via a dual mitogen-activated protein kinase mechanism. Arthritis Rheum, 48, 993-1001 (2003). (Pubitemid 36418241)
97. Numasaki, M., J. Fukushi, M. Ono, S. K. Narula, P. J. Zavodny, T. Kudo, P. D. Robbins, H. Tahara & M. T. Lotze: Interleukin-17 promotes angiogenesis and tumor growth. Blood, 101, 2620-7 (2003). (Pubitemid 36857622)
98. Takahashi, H., M. Numasaki, M. T. Lotze & H. Sasaki: Interleukin-17 enhances bFGF-, HGF- and VEGF-induced growth of vascular endothelial cells. Immunol Lett, 98, 189-93 (2005). (Pubitemid 40602629)
99. Jovanovic, D. V., J. A. Di Battista, J. Martel-Pelletier, F. C. Jolicoeur, Y. He, M. Zhang, F. Mineau & J. P. Pelletier: IL-17 stimulates the production and expression of proinflammatory cytokines, IL-beta and TNF-alpha, by human macrophages. J Immunol, 160, 3513-21 (1998). (Pubitemid 28164746)
100. Wang, L., T. Yi, M. Kortylewski, D. M. Pardoll, D. Zeng & H. Yu: IL-17 can promote tumor growth through an IL-6- Stat3 signaling pathway. J Exp Med, 206, 1457-64 (2009).
101. Sonobe, Y., H. Takeuchi, K. Kataoka, H. Li, S. Jin, M. Mimuro, Y. Hashizume, Y. Sano, T. Kanda, T. Mizuno & A. Suzumura: Interleukin-25 expressed by brain capillary endothelial cells maintains blood-brain barrier function in a protein kinase Cepsilon-dependent manner. J Biol Chem, 284, 31834-42 (2009).
102. Thebault, P., N. Lhermite, G. Tilly, L. Le Texier, T. Quillard, M. Heslan, I. Anegon, J. P. Soulillou, S. Brouard, B. Charreau, M. C. Cuturi & E. Chiffoleau: The C-type lectin-like receptor CLEC-1, expressed by myeloid cells and endothelial cells, is up-regulated by immunoregulatory mediators and moderates T cell activation. J Immunol, 183, 3099-108 (2009).
103. Kim, Y. S., S. W. Hong, J. P. Choi, T. S. Shin, H. G. Moon, E. J. Choi, S. G. Jeon, S. Y. Oh, Y. S. Gho, Z. Zhu & Y. K. Kim: Vascular endothelial growth factor is a key mediator in the development of T cell priming and its polarization to type 1 and type 17 T helper cells in the airways. J Immunol, 183, 5113-20 (2009).
104. Patel, D. N., C. A. King, S. R. Bailey, J. W. Holt, K. Venkatachalam, A. Agrawal, A. J. Valente & B. Chandrasekar: Interleukin-17 stimulates C-reactive protein expression in hepatocytes and smooth muscle cells via p38 MAPK and ERK1/2-dependent NF-kappaB and C/EBPbeta activation. J Biol Chem, 282, 27229-38 (2007). (Pubitemid 47501976)
105. Cheng, G., L. Wei, W. Xiurong, L. Xiangzhen, Z. Shiguang & F. Songbin: IL-17 Stimulates Migration of Carotid Artery Vascular Smooth Muscle Cells in an MMP- 9 Dependent Manner via p38 MAPK and ERK1/2- Dependent NF-kappaB and AP-1 Activation. Cell Mol Neurobiol (2009).
106. Van Den Berg, A., M. Kuiper, M. Snoek, W. Timens, D. S. Postma, H. M. Jansen & R. Lutter: Interleukin-17 induces hyperresponsive interleukin-8 and interleukin-6 production to tumor necrosis factor-alpha in structural lung cells. Am J Respir Cell Mol Biol, 33, 97-104 (2005). (Pubitemid 40961019)
107. Yao, Z., M. K. Spriggs, J. M. Derry, L. Strockbine, L. S. Park, T. VandenBos, J. D. Zappone, S. L. Painter & R. J. Armitage: Molecular characterization of the human interleukin (IL)-17 receptor. Cytokine, 9, 794-800 (1997). (Pubitemid 27494143)
108. Silva, W. A., Jr., D. T. Covas, R. A. Panepucci, R. Proto-Siqueira, J. L. Siufi, D. L. Zanette, A. R. Santos & M. A. Zago: The profile of gene expression of human marrow mesenchymal stem cells. Stem Cells, 21, 661-9 (2003). (Pubitemid 37329159)
109. Moseley, T. A., D. R. Haudenschild, L. Rose & A. H. Reddi: Interleukin-17 family and IL-17 receptors. Cytokine Growth Factor Rev, 14, 155-74 (2003). (Pubitemid 36389528)
110. Kuestner, R. E., D. W. Taft, A. Haran, C. S. Brandt, T. Brender, K. Lum, B. Harder, S. Okada, C. D. Ostrander, J. L. Kreindler, S. J. Aujla, B. Reardon, M. Moore, P. Shea, R. Schreckhise, T. R. Bukowski, S. Presnell, P. Guerra-Lewis, J. Parrish-Novak, J. L. Ellsworth, S. Jaspers, K. E. Lewis, M. Appleby, J. K. Kolls, M. Rixon, J. W. West, Z. Gao & S. D. Levin: Identification of the IL-17 receptor related molecule IL-17RC as the receptor for IL-17F. J Immunol, 179, 5462-73 (2007).
111. Ye, P., F. H. Rodriguez, S. Kanaly, K. L. Stocking, J. Schurr, P. Schwarzenberger, P. Oliver, W. Huang, P. Zhang, J. Zhang, J. E. Shellito, G. J. Bagby, S. Nelson, K. Charrier, J. J. Peschon & J. K. Kolls: Requirement of interleukin 17 receptor signaling for lung CXC chemokine and granulocyte colony-stimulating factor expression, neutrophil recruitment, and host defense. J Exp Med, 194, 519-27 (2001). (Pubitemid 32835046)
112. Kramer, J. M., L. Yi, F. Shen, A. Maitra, X. Jiao, T. Jin & S. L. Gaffen: Evidence for ligand-independent multimerization of the IL-17 receptor. J Immunol, 176, 711-5 (2006). (Pubitemid 43099664)
113. Toy, D., D. Kugler, M. Wolfson, T. Vanden Bos, J. Gurgel, J. Derry, J. Tocker & J. Peschon: Cutting edge: interleukin 17 signals through a heteromeric receptor complex. J Immunol, 177, 36-9 (2006). (Pubitemid 43939112)
114. Wright, J. F., F. Bennett, B. Li, J. Brooks, D. P. Luxenberg, M. J. Whitters, K. N. Tomkinson, L. J. Fitz, N. M. Wolfman, M. Collins, K. Dunussi-Joannopoulos, M. Chatterjee-Kishore & B. M. Carreno: The human IL-17F/IL-17A heterodimeric cytokine signals through the IL- 17RA/IL-17RC receptor complex. J Immunol, 181, 2799-805 (2008).
115. Claudio, E., S. U. Sonder, S. Saret, G. Carvalho, T. R. Ramalingam, T. A. Wynn, A. Chariot, A. Garcia- Perganeda, A. Leonardi, A. Paun, A. Chen, N. Y. Ren, H. Wang & U. Siebenlist: The adaptor protein CIKS/Act1 is essential for IL-25-mediated allergic airway inflammation. J Immunol, 182, 1617-30 (2009).
116. Novatchkova, M., A. Leibbrandt, J. Werzowa, A. Neubuser & F. Eisenhaber: The STIR-domain superfamily in signal transduction, development and immunity. Trends Biochem Sci, 28, 226-9 (2003). (Pubitemid 36588662)
117. Murphy, J. M. & I. G. Young: IL-3, IL-5, and GMCSF signaling: crystal structure of the human beta-common receptor. Vitam Horm, 74, 1-30 (2006).
118. Miggin, S. M., E. Palsson-McDermott, A. Dunne, C. Jefferies, E. Pinteaux, K. Banahan, C. Murphy, P. Moynagh, M. Yamamoto, S. Akira, N. Rothwell, D. Golenbock, K. A. Fitzgerald & L. A. O'Neill: NF-kappaB activation by the Toll-IL-1 receptor domain protein MyD88 adapter-like is regulated by caspase-1. Proc Natl Acad Sci U S A, 104, 3372-7 (2007). (Pubitemid 46364166)
119. Maitra, A., F. Shen, W. Hanel, K. Mossman, J. Tocker, D. Swart & S. L. Gaffen: Distinct functional motifs within the IL- 17 receptor regulate signal transduction and target gene expression. Proc Natl Acad Sci U S A, 104, 7506-11 (2007). (Pubitemid 47185936)
120. Shen, F., N. Li, P. Gade, D. V. Kalvakolanu, T. Weibley, B. Doble, J. R. Woodgett, T. D. Wood & S. L. Gaffen: IL-17 receptor signaling inhibits C/EBP-beta by sequential phosphorylation of the regulatory 2 domain. Sci Signal, 2, ra8 (2009).
121. Chang, S. H., H. Park & C. Dong: Act1 adaptor protein is an immediate and essential signaling component of interleukin-17 receptor. J Biol Chem, 281, 35603-7 (2006). (Pubitemid 46041290)
122. Qian, Y., C. Liu, J. Hartupee, C. Z. Altuntas, M. F. Gulen, D. Jane-Wit, J. Xiao, Y. Lu, N. Giltiay, J. Liu, T. Kordula, Q. W. Zhang, B. Vallance, S. Swaidani, M. Aronica, V. K. Tuohy, T. Hamilton & X. Li: The adaptor Act1 is required for interleukin 17-dependent signaling associated with autoimmune and inflammatory disease. Nat Immunol, 8, 247-56 (2007). (Pubitemid 46745374)
123. Qian, Y., J. Qin, G. Cui, M. Naramura, E. C. Snow, C. F. Ware, R. L. Fairchild, S. A. Omori, R. C. Rickert, M. Scott, B. L. Kotzin & X. Li: Act1, a negative regulator in CD40- and BAFF-mediated B cell survival. Immunity, 21, 575-87 (2004). (Pubitemid 39370512)
124. Sato, S., H. Sanjo, K. Takeda, J. Ninomiya-Tsuji, M. Yamamoto, T. Kawai, K. Matsumoto, O. Takeuchi & S. Akira: Essential function for the kinase TAK1 in innate and adaptive immune responses. Nat Immunol, 6, 1087-95 (2005). (Pubitemid 41541786)
125. Awane, M., P. G. Andres, D. J. Li & H. C. Reinecker: NF-kappa B-inducing kinase is a common mediator of IL- 17-, TNF-alpha-, and IL-1 beta-induced chemokine promoter activation in intestinal epithelial cells. J Immunol, 162, 5337-44 (1999). (Pubitemid 29307140)
126. Hata, K., A. Andoh, M. Shimada, S. Fujino, S. Bamba, Y. Araki, T. Okuno, Y. Fujiyama & T. Bamba: IL-17 stimulates inflammatory responses via NF-kappaB and MAP kinase pathways in human colonic myofibroblasts. Am J Physiol Gastrointest Liver Physiol, 282, G1035-44 (2002). (Pubitemid 34651610)
127. Ruddy, M. J., G. C. Wong, X. K. Liu, H. Yamamoto, S. Kasayama, K. L.
128. Anderson, P.: Post-transcriptional control of cytokine production. Nat Immunol, 9, 353-9 (2008). (Pubitemid 351405104)
129. Shen, M. M.: Identification of differentially expressed genes in mouse development using differential display and in situ hybridization. Methods, 24, 15-27 (2001). (Pubitemid 32846438)
130. Gran, B., G. X. Zhang, S. Yu, J. Li, X. H. Chen, E. S. Ventura, M. Kamoun & A. Rostami: IL-12p35-deficient mice are susceptible to experimental autoimmune encephalomyelitis: evidence for redundancy in the IL-12 system in the induction of central nervous system autoimmune demyelination. J Immunol, 169, 7104-10 (2002). (Pubitemid 36899299)
131. Zhang, G. X., B. Gran, S. Yu, J. Li, I. Siglienti, X. Chen, M. Kamoun & A. Rostami: Induction of experimental autoimmune encephalomyelitis in IL-12 receptor-beta 2-deficient mice: IL-12 responsiveness is not required in the pathogenesis of inflammatory demyelination in the central nervous system. J Immunol, 170, 2153-60 (2003). (Pubitemid 36197439)
132. Elson, C. O., Y. Cong, C. T. Weaver, T. R. Schoeb, T. K. McClanahan, R. B. Fick & R. A. Kastelein: Monoclonal anti-interleukin 23 reverses active colitis in a T cellmediated model in mice. Gastroenterology, 132, 2359-70 (2007). (Pubitemid 46890867)
133. Yang, X. O., S. H. Chang, H. Park, R. Nurieva, B. Shah, L. Acero, Y. H. Wang, K. S. Schluns, R. R. Broaddus, Z. Zhu & C. Dong: Regulation of inflammatory responses by IL-17F. J Exp Med, 205, 1063-75 (2008). (Pubitemid 351679682)
134. Nakae, S., A. Nambu, K. Sudo & Y. Iwakura: Suppression of immune induction of collagen-induced arthritis in IL-17-deficient mice. J Immunol, 171, 6173-7 (2003). (Pubitemid 37467240)
135. Sato, K., A. Suematsu, K. Okamoto, A. Yamaguchi, Y. Morishita, Y. Kadono, S. Tanaka, T. Kodama, S. Akira, Y. Iwakura, D. J. Cua & H. Takayanagi: Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction. J Exp Med, 203, 2673-82 (2006). (Pubitemid 44833343)
136. Moran, E. M., R. Mullan, J. McCormick, M. Connolly, O. Sullivan, O. Fitzgerald, B. Bresnihan, D. J. Veale & U. Fearon: Human rheumatoid arthritis tissue production of IL-17A drives matrix and cartilage degradation: synergy with tumour necrosis factor-alpha, Oncostatin M and response to biologic therapies. Arthritis Res Ther, 11, R113 (2009).
137. Eid, R. E., D. A. Rao, J. Zhou, S. F. Lo, H. Ranjbaran, A. Gallo, S. I. Sokol, S. Pfau, J. S. Pober & G. Tellides: Interleukin-17 and interferon-gamma are produced concomitantly by human coronary artery-infiltrating T cells and act synergistically on vascular smooth muscle cells. Circulation, 119, 1424-32 (2009).
138. Taleb, S., M. Romain, B. Ramkhelawon, C. Uyttenhove, G. Pasterkamp, O. Herbin, B. Esposito, N. Perez, H. Yasukawa, J. Van Snick, A. Yoshimura, A. Tedgui & Z. Mallat: Loss of SOCS3 expression in T cells reveals a regulatory role for interleukin-17 in atherosclerosis. J Exp Med, 206, 2067-77 (2009).
139. Xie, J. J., J. Wang, T. T. Tang, J. Chen, X. L. Gao, J. Yuan, Z. H. Zhou, M. Y. Liao, R. Yao, X. Yu, D. Wang, Y. Cheng, Y. H. Liao & X. Cheng: The Th17/Treg functional imbalance during atherogenesis in ApoE (-/-) mice Th17/Treg imbalance in atherogenesis. Cytokine (2009).
140. Guzik, T. J., P. J. Marvar, M. Czesnikiewicz-Guzik & R. Korbut: Perivascular adipose tissue as a messenger of the brain-vessel axis: role in vascular inflammation and dysfunction. J Physiol Pharmacol, 58, 591-610 (2007).
141. van Es, T., G. H. van Puijvelde, O. H. Ramos, F. M. Segers, L. A. Joosten, W. B. van den Berg, I. M. Michon, P. de Vos, T. J. van Berkel & J. Kuiper: Attenuated atherosclerosis upon IL-17R signaling disruption in LDLr deficient mice. Biochem Biophys Res Commun, 388, 261-5 (2009).
142. Maitra, U., S. Davis, C. M. Reilly & L. Li: Differential regulation of Foxp3 and IL-17 expression in CD4 T helper cells by IRAK-1. J Immunol, 182, 5763-9 (2009).
143. Robb, L., K. Boyle, S. Rakar, L. Hartley, J. Lochland, A. W. Roberts, W. S. Alexander & D. Metcalf: Genetic reduction of embryonic leukemia-inhibitory factor production rescues placentation in SOCS3-null embryos but does not prevent inflammatory disease. Proc Natl Acad Sci U S A, 102, 16333-8 (2005). (Pubitemid 41688914)
144. Chen, Z., A. Laurence, Y. Kanno, M. Pacher-Zavisin, B. M. Zhu, C. Tato, A. Yoshimura, L. Hennighausen & J. J. O'Shea: Selective regulatory function of Socs3 in the formation of IL-17-secreting T cells. Proc Natl Acad Sci U S A, 103, 8137-42 (2006). (Pubitemid 43801065)
145. Darrasse-Jeze, G., S. Deroubaix, H. Mouquet, G. D. Victora, T. Eisenreich, K. H. Yao, R. F. Masilamani, M. L. Dustin, A. Rudensky, K. Liu & M. C. Nussenzweig: Feedback control of regulatory T cell homeostasis by dendritic cells in vivo. J Exp Med, 206, 1853-62 (2009).
146. Cui, G., X. Qin, Y. Zhang, Z. Gong, B. Ge & Y. Q. Zang: Berberine differentially modulates the activities of ERK, p38 MAPK, and JNK to suppress Th17 and Th1 T cell differentiation in type 1 diabetic mice. J Biol Chem, 284, 28420-9 (2009).
147. Jain, R., D. M. Tartar, R. K. Gregg, R. D. Divekar, J. J. Bell, H. H. Lee, P. Yu, J. S. Ellis, C. M. Hoeman, C. L. Franklin & H. Zaghouani: Innocuous IFNgamma induced by adjuvant-free antigen restores normoglycemia in NOD mice through inhibition of IL-17 production. J Exp Med, 205, 207-18 (2008). (Pubitemid 351185727)
148. Boehm, B. O., S. Rosinger, G. Sauer, B. J. Manfras, D. Palesch, S. Schiekofer, H. Kalbacher & T. Burster: Protease-resistant human GAD-derived altered peptide ligands decrease TNF-alpha and IL-17 production in peripheral blood cells from patients with type 1 diabetes mellitus. Mol Immunol, 46, 2576-84 (2009).
149. Bradshaw, E. M., K. Raddassi, W. Elyaman, T. Orban, P. A. Gottlieb, S. C. Kent & D. A. Hafler: Monocytes from patients with type 1 diabetes spontaneously secrete proinflammatory cytokines inducing Th17 cells. J Immunol, 183, 4432-9 (2009).
150. Aujla, S. J., Y. R. Chan, M. Zheng, M. Fei, D. J. Askew, D. A. Pociask, T. A. Reinhart, F. McAllister, J. Edeal, K. Gaus, S. Husain, J. L. Kreindler, P. J. Dubin, J. M. Pilewski, M. M. Myerburg, C. A. Mason, Y. Iwakura & J. K. Kolls: IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia. Nat Med, 14, 275-81 (2008). (Pubitemid 351347908)
151. Happel, K. I., P. J. Dubin, M. Zheng, N. Ghilardi, C. Lockhart, L. J. Quinton, A. R. Odden, J. E. Shellito, G. J. Bagby, S. Nelson & J. K. Kolls: Divergent roles of IL-23 and IL-12 in host defense against Klebsiella pneumoniae. J Exp Med, 202, 761-9 (2005). (Pubitemid 41345965)
152. Wu, Q., R. J. Martin, J. G. Rino, R. Breed, R. M. Torres & H. W. Chu: IL-23-dependent IL-17 production is essential in neutrophil recruitment and activity in mouse lung defense against respiratory Mycoplasma pneumoniae infection. Microbes Infect, 9, 78-86 (2007). (Pubitemid 46149421)
153. Huang, W., L. Na, P. L. Fidel & P. Schwarzenberger: Requirement of interleukin-17A for systemic anti-Candida albicans host defense in mice. J Infect Dis, 190, 624-31 (2004). (Pubitemid 38982105)
154. Oppenheim, J. J., A. Biragyn, L. W. Kwak & D. Yang: Roles of antimicrobial peptides such as defensins in innate and adaptive immunity. Ann Rheum Dis, 62 Suppl 2, ii17-21 (2003).
155. Costantino, C. M., C. M. Baecher-Allan & D. A. Hafler: Human regulatory T cells and autoimmunity. Eur J Immunol, 38, 921-4 (2008).
156. Pacholczyk, R. & J. Kern: The T-cell receptor repertoire of regulatory T cells. Immunology, 125, 450-8 (2008).
157. Buckner, J. H. & S. F. Ziegler: Functional analysis of FOXP3. Ann N Y Acad Sci, 1143, 151-69 (2008).
158. Horwitz, D. A., S. G. Zheng & J. D. Gray: Natural and TGF-beta-induced Foxp3 (+)CD4 (+) CD25 (+) regulatory T cells are not mirror images of each other. Trends Immunol, 29, 429-35 (2008).
159. George, J.: Mechanisms of disease: the evolving role of regulatory T cells in atherosclerosis. Nat Clin Pract Cardiovasc Med, 5, 531-40 (2008).
160. Andre, S., D. F. Tough, S. Lacroix-Desmazes, S. V. Kaveri & J. Bayry: Surveillance of antigen-presenting cells by CD4+ CD25+ regulatory T cells in autoimmunity: immunopathogenesis and therapeutic implications. Am J Pathol, 174, 1575-87 (2009).
161. Haribhai, D., W. Lin, B. Edwards, J. Ziegelbauer, N. H. Salzman, M. R. Carlson, S. H. Li, P. M. Simpson, T. A. Chatila & C. B. Williams: A central role for induced regulatory T cells in tolerance induction in experimental colitis. J Immunol, 182, 3461-8 (2009).
162. Chatila, T. A.: Regulatory T cells: key players in tolerance and autoimmunity. Endocrinol Metab Clin North Am, 38, 265-72, vii (2009).
163. Lal, G. & J. S. Bromberg: Epigenetic mechanisms of regulation of Foxp3 expression. Blood, 114, 3727-35 (2009).
164. Bollyky, P. L., B. A. Falk, R. P. Wu, J. H. Buckner, T. N. Wight & G. T. Nepom: Intact extracellular matrix and the maintenance of immune tolerance: high molecular weight hyaluronan promotes persistence of induced CD4+CD25+ regulatory T cells. J Leukoc Biol, 86, 567-72 (2009).
165. Valencia, X. & P. E. Lipsky: CD4+CD25+FoxP3+ regulatory T cells in autoimmune diseases. Nat Clin Pract Rheumatol, 3, 619-26 (2007).
166. von Herrath, M. G. & L. C. Harrison: Antigen-induced regulatory T cells in autoimmunity. Nat Rev Immunol, 3, 223-32 (2003). (Pubitemid 37323207)
167. Yan, Y., Y. Chen, F. Yang, I. H. Chen, Z. Xiong, J. Wang, L. B. Lachman, H. Wang & X. F. Yang: HLA-A2.1- restricted T cells react to SEREX-defined tumor antigen CML66L and are suppressed by CD4+CD25+ regulatory T cells. Int J Immunopathol Pharmacol, 20, 75-89 (2007). (Pubitemid 46506878)
168. Zhou, X., S. L. Bailey-Bucktrout, L. T. Jeker, C. Penaranda, M. Martinez-Llordella, M. Ashby, M. Nakayama, W. Rosenthal & J. A. Bluestone: Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo. Nat Immunol, 10, 1000-7 (2009).
169. Sakaguchi, S.: Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responses. Annu Rev Immunol, 22, 531-62 (2004). (Pubitemid 38680433)
170. Kim, J. M., J. P. Rasmussen & A. Y. Rudensky: Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice. Nat Immunol, 8, 191-7 (2007). (Pubitemid 46152650)
171. O'Connor, R. A., K. H. Malpass & S. M. Anderton: The inflamed central nervous system drives the activation and rapid proliferation of Foxp3+ regulatory T cells. J Immunol, 179, 958-66 (2007).
172. Bettelli, E., T. Korn, M. Oukka & V. K. Kuchroo: Induction and effector functions of T (H)17 cells. Nature, 453, 1051-7 (2008). (Pubitemid 351871737)
173. Yang, L., D. E. Anderson, C. Baecher-Allan, W. D. Hastings, E. Bettelli, M. Oukka, V. K. Kuchroo & D. A. Hafler: IL-21 and TGF-beta are required for differentiation of human T (H)17 cells. Nature, 454, 350-2 (2008).
174. Zhou, L., J. E. Lopes, M. M. Chong, Ivanov, II, R. Min, G. D. Victora, Y. Shen, J. Du, Y. P. Rubtsov, A. Y. Rudensky, S. F. Ziegler & D. R. Littman: TGF-beta-induced Foxp3 inhibits T (H)17 cell differentiation by antagonizing RORgamma t function. Nature, 453, 236-40 (2008). (Pubitemid 351667978)
175. Du, J., C. Huang, B. Zhou & S. F. Ziegler: Isoformspecific inhibition of RORalpha-mediated transcriptional activation by human FOXP3. J Immunol, 180, 4785-92 (2008).
176. Laurence, A., C. M. Tato, T. S. Davidson, Y. Kanno, Z. Chen, Z. Yao, R. B. Blank, F. Meylan, R. Siegel, L. Hennighausen, E. M. Shevach & J. O'Shea J: Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation. Immunity, 26, 371-81 (2007). (Pubitemid 46413906)
177. Mucida, D., Y. Park, G. Kim, O. Turovskaya, I. Scott, M. Kronenberg & H. Cheroutre: Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid. Science, 317, 256-60 (2007). (Pubitemid 47076203)
178. Adamson, A. S., K. Collins, A. Laurence & J. J. O'Shea: The Current STATus of lymphocyte signaling: new roles for old players. Curr Opin Immunol, 21, 161-6 (2009).
179. Fletcher, J. M., R. Lonergan, L. Costelloe, K. Kinsella, B. Moran, C. O'Farrelly, N. Tubridy & K. H. Mills: CD39+Foxp3+ regulatory T Cells suppress pathogenic Th17 cells and are impaired in multiple sclerosis. J Immunol, 183, 7602-10 (2009).
180. Weaver, C. T. & R. D. Hatton: Interplay between the TH17 and TReg cell lineages: a (co-)evolutionary perspective. Nat Rev Immunol, 9, 883-9 (2009).