메뉴 건너뛰기




Volumn 182, Issue 1, 2009, Pages 259-273

Epigenetic regulation of Foxp3 expression in regulatory T cells by DNA methylation

Author keywords

[No Author keywords available]

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; CYTOKINE; DNA; DNA METHYLTRANSFERASE 1; DNA METHYLTRANSFERASE 3B; GENOMIC DNA; HISTONE; HISTONE H3; INTERLEUKIN 6; METHYL CPG BINDING PROTEIN 2; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR FOXP3; TRANSCRIPTION FACTOR SP1; TRANSCRIPTION FACTOR TIEG1; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; AZACITIDINE; DRUG DERIVATIVE; FORKHEAD TRANSCRIPTION FACTOR; FOXP3 PROTEIN, HUMAN;

EID: 59849085588     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.182.1.259     Document Type: Article
Times cited : (483)

References (55)
  • 1
    • 34547749066 scopus 로고    scopus 로고
    • Emerging challenges in regulatory T cell function and biology
    • Sakaguchi, S., and F. Powrie. 2007. Emerging challenges in regulatory T cell function and biology. Science 317: 627-629.
    • (2007) Science , vol.317 , pp. 627-629
    • Sakaguchi, S.1    Powrie, F.2
  • 2
    • 0037111521 scopus 로고    scopus 로고
    • + T cell-mediated graft rejection: implications for anti-CD154 immunotherapy
    • + T cell-mediated graft rejection: implications for anti-CD154 immunotherapy. J. Immunol. 169: 5401-5404.
    • (2002) J. Immunol , vol.169 , pp. 5401-5404
    • van Maurik, A.1    Herber, M.2    Wood, K.J.3    Jones, N.D.4
  • 3
    • 33847647528 scopus 로고    scopus 로고
    • Regulatory T cells and cancer
    • Wang, H. Y., and R. F. Wang. 2007. Regulatory T cells and cancer. Curr. Opin. Immunol. 19: 217-223.
    • (2007) Curr. Opin. Immunol , vol.19 , pp. 217-223
    • Wang, H.Y.1    Wang, R.F.2
  • 6
    • 27544481941 scopus 로고    scopus 로고
    • A function for interleukin 2 in Foxp3-expressing regulatory T cells
    • Fontenot, J. D., J. P. Rasmussen, M. A. Gavin, and A. Y. Rudensky. 2005. A function for interleukin 2 in Foxp3-expressing regulatory T cells. Nat. Immunol. 6: 1142-1151.
    • (2005) Nat. Immunol , vol.6 , pp. 1142-1151
    • Fontenot, J.D.1    Rasmussen, J.P.2    Gavin, M.A.3    Rudensky, A.Y.4
  • 7
    • 34447265236 scopus 로고    scopus 로고
    • CREB/ATF-dependent T cell receptor-induced FoxP3 gene expression: A role for DNA methylation
    • Kim, H. P., and W. J. Leonard. 2007. CREB/ATF-dependent T cell receptor-induced FoxP3 gene expression: a role for DNA methylation. J. Exp. Med. 204: 1543-1551.
    • (2007) J. Exp. Med , vol.204 , pp. 1543-1551
    • Kim, H.P.1    Leonard, W.J.2
  • 12
    • 34247271308 scopus 로고    scopus 로고
    • Maintenance of the Foxp3-dependent developmental program in mature regulatory T cells requires continued expression of Foxp3
    • Williams, L. M., and A. Y. Rudensky. 2007. Maintenance of the Foxp3-dependent developmental program in mature regulatory T cells requires continued expression of Foxp3. Nat. Immunol. 8: 277-284.
    • (2007) Nat. Immunol , vol.8 , pp. 277-284
    • Williams, L.M.1    Rudensky, A.Y.2
  • 13
    • 17144374934 scopus 로고    scopus 로고
    • Regulatory T-cell therapy: Is it ready for the clinic?
    • Bluestone, J. A. 2005. Regulatory T-cell therapy: is it ready for the clinic? Nat. Rev. 5: 343-349.
    • (2005) Nat. Rev , vol.5 , pp. 343-349
    • Bluestone, J.A.1
  • 15
    • 0035312289 scopus 로고    scopus 로고
    • The MeCP1 complex represses transcription through preferential binding, remodeling, and deacetylating methylated nucleosomes
    • Feng, Q., and Y. Zhang. 2001. The MeCP1 complex represses transcription through preferential binding, remodeling, and deacetylating methylated nucleosomes. Genes Dev. 15: 827-832.
    • (2001) Genes Dev , vol.15 , pp. 827-832
    • Feng, Q.1    Zhang, Y.2
  • 20
    • 33646012294 scopus 로고    scopus 로고
    • T helper cell differentiation: Regulation by cis elements and epigenetics
    • Lee, G. R., S. T. Kim, C. G. Spilianakis, P. E. Fields, and R. A. Flavell. 2006. T helper cell differentiation: regulation by cis elements and epigenetics. Immunity 24: 369-379.
    • (2006) Immunity , vol.24 , pp. 369-379
    • Lee, G.R.1    Kim, S.T.2    Spilianakis, C.G.3    Fields, P.E.4    Flavell, R.A.5
  • 21
    • 0037114123 scopus 로고    scopus 로고
    • Cutting edge: Distal regulatory elements are required to achieve selective expression of IFN-γ in Th1/Tc1 effector cells
    • Soutto, M., W. Zhou, and T. M. Aune. 2002. Cutting edge: distal regulatory elements are required to achieve selective expression of IFN-γ in Th1/Tc1 effector cells. J. Immunol. 169: 6664-6667.
    • (2002) J. Immunol , vol.169 , pp. 6664-6667
    • Soutto, M.1    Zhou, W.2    Aune, T.M.3
  • 22
    • 5444237577 scopus 로고    scopus 로고
    • Long-range intrachromosomal interactions in the T helper type 2 cytokine locus
    • Spilianakis, C. G., and R. A. Flavell. 2004. Long-range intrachromosomal interactions in the T helper type 2 cytokine locus. Nat. Immunol. 5: 1017-1027.
    • (2004) Nat. Immunol , vol.5 , pp. 1017-1027
    • Spilianakis, C.G.1    Flavell, R.A.2
  • 23
    • 0038638583 scopus 로고    scopus 로고
    • An epigenetic view of helper T cell differentiation
    • Ansel, K. M., D. U. Lee, and A. Rao. 2003. An epigenetic view of helper T cell differentiation. Nat. Immunol. 4: 616-623.
    • (2003) Nat. Immunol , vol.4 , pp. 616-623
    • Ansel, K.M.1    Lee, D.U.2    Rao, A.3
  • 24
    • 0032412441 scopus 로고    scopus 로고
    • Modulation of chromatin structure regulates cytokine gene expression during T cell differentiation
    • Agarwal, S., and A. Rao. 1998. Modulation of chromatin structure regulates cytokine gene expression during T cell differentiation. Immunity 9: 765-775.
    • (1998) Immunity , vol.9 , pp. 765-775
    • Agarwal, S.1    Rao, A.2
  • 25
    • 10344234192 scopus 로고    scopus 로고
    • Th2-specific chromatin remodeling and enhancer activity in the Th2 cytokine locus control region
    • Fields, P. E., G. R. Lee, S. T. Kim, V. V. Bartsevich, and R. A. Flavell. 2004. Th2-specific chromatin remodeling and enhancer activity in the Th2 cytokine locus control region. Immunity 21: 865-876.
    • (2004) Immunity , vol.21 , pp. 865-876
    • Fields, P.E.1    Lee, G.R.2    Kim, S.T.3    Bartsevich, V.V.4    Flavell, R.A.5
  • 26
    • 0033104503 scopus 로고    scopus 로고
    • Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-β
    • Yang, X., J. J. Letterio, R. J. Lechleider, L. Chen, R. Hayman, H. Gu, A. B. Roberts, and C. Deng. 1999. Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-β. EMBO J. 18: 1280-1291.
    • (1999) EMBO J , vol.18 , pp. 1280-1291
    • Yang, X.1    Letterio, J.J.2    Lechleider, R.J.3    Chen, L.4    Hayman, R.5    Gu, H.6    Roberts, A.B.7    Deng, C.8
  • 27
    • 20744454264 scopus 로고    scopus 로고
    • Stat1 and Stat2 but not Stat3 arbitrate contradictory growth signals elicited by α/β interferon in T lymphocytes
    • Gimeno, R., C. K. Lee, C. Schindler, and D. E. Levy. 2005. Stat1 and Stat2 but not Stat3 arbitrate contradictory growth signals elicited by α/β interferon in T lymphocytes. Mol. Cell. Biol. 25: 5456-5465.
    • (2005) Mol. Cell. Biol , vol.25 , pp. 5456-5465
    • Gimeno, R.1    Lee, C.K.2    Schindler, C.3    Levy, D.E.4
  • 30
    • 38949112498 scopus 로고    scopus 로고
    • Germinal center B-cell-associated DNA hypomethylation at transcriptional regions of the AID gene
    • Fujimura, S., T. Matsui, K. Kuwahara, K. Maeda, and N. Sakaguchi. 2008. Germinal center B-cell-associated DNA hypomethylation at transcriptional regions of the AID gene. Mol. Immunol. 45: 1712-1719.
    • (2008) Mol. Immunol , vol.45 , pp. 1712-1719
    • Fujimura, S.1    Matsui, T.2    Kuwahara, K.3    Maeda, K.4    Sakaguchi, N.5
  • 32
    • 0027960055 scopus 로고
    • Sp1 sites in the mouse aprt gene promoter are required to prevent methylation of the CpG island
    • Macleod, D., J. Charlton, J. Mullins, and A. P. Bird. 1994. Sp1 sites in the mouse aprt gene promoter are required to prevent methylation of the CpG island. Genes Dev. 8: 2282-2292.
    • (1994) Genes Dev , vol.8 , pp. 2282-2292
    • Macleod, D.1    Charlton, J.2    Mullins, J.3    Bird, A.P.4
  • 33
    • 0037154963 scopus 로고    scopus 로고
    • Cooperation between complexes that regulate chromatin structure and transcription
    • Narlikar, G. J., H. Y. Fan, and R. E. Kingston. 2002. Cooperation between complexes that regulate chromatin structure and transcription. Cell 108: 475-487.
    • (2002) Cell , vol.108 , pp. 475-487
    • Narlikar, G.J.1    Fan, H.Y.2    Kingston, R.E.3
  • 35
    • 39449083806 scopus 로고    scopus 로고
    • The E3 ubiquitin ligase Itch regulates expression of transcription factor Foxp3 and airway inflammation by enhancing the function of transcription factor TIEG1
    • Venuprasad, K., H. Huang, Y. Harada, C. Elly, M. Subramaniam, T. Spelsberg, J. Su, and Y. C. Liu. 2008. The E3 ubiquitin ligase Itch regulates expression of transcription factor Foxp3 and airway inflammation by enhancing the function of transcription factor TIEG1. Nat. Immunol. 9: 245-253.
    • (2008) Nat. Immunol , vol.9 , pp. 245-253
    • Venuprasad, K.1    Huang, H.2    Harada, Y.3    Elly, C.4    Subramaniam, M.5    Spelsberg, T.6    Su, J.7    Liu, Y.C.8
  • 38
    • 33646577466 scopus 로고    scopus 로고
    • Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells
    • Bettelli, E., Y. Carrier, W. Gao, T. Korn, T. B. Strom, M. Oukka, H. L. Weiner, and V. K. Kuchroo. 2006. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature 441: 235-238.
    • (2006) Nature , vol.441 , pp. 235-238
    • Bettelli, E.1    Carrier, Y.2    Gao, W.3    Korn, T.4    Strom, T.B.5    Oukka, M.6    Weiner, H.L.7    Kuchroo, V.K.8
  • 40
    • 0037436119 scopus 로고    scopus 로고
    • + T cell-mediated suppression by dendritic cells
    • + T cell-mediated suppression by dendritic cells. Science 299: 1033-1036.
    • (2003) Science , vol.299 , pp. 1033-1036
    • Pasare, C.1    Medzhitov, R.2
  • 41
    • 27144509196 scopus 로고    scopus 로고
    • DNA methyltransferase inhibitors and the development of epigenetic cancer therapies
    • Lyko, F., and R. Brown. 2005. DNA methyltransferase inhibitors and the development of epigenetic cancer therapies. J. Natl. Cancer Inst. 97: 1498-1506.
    • (2005) J. Natl. Cancer Inst , vol.97 , pp. 1498-1506
    • Lyko, F.1    Brown, R.2
  • 42
    • 2642531973 scopus 로고    scopus 로고
    • Epigenetics in human disease and prospects for epigenetic therapy
    • Egger, G., G. Liang, A. Aparicio, and P. A. Jones. 2004. Epigenetics in human disease and prospects for epigenetic therapy. Nature 429: 457-463.
    • (2004) Nature , vol.429 , pp. 457-463
    • Egger, G.1    Liang, G.2    Aparicio, A.3    Jones, P.A.4
  • 44
    • 35448930435 scopus 로고    scopus 로고
    • + FOXP3 T cells by T-cell receptor stimulation is transforming growth factor-β dependent but does not confer a regulatory phenotype
    • + FOXP3 T cells by T-cell receptor stimulation is transforming growth factor-β dependent but does not confer a regulatory phenotype. Blood 110: 2983-2990.
    • (2007) Blood , vol.110 , pp. 2983-2990
    • Tran, D.Q.1    Ramsey, H.2    Shevach, E.M.3
  • 52
    • 33746651038 scopus 로고    scopus 로고
    • STAT3 induces transcription of the DNA methyltransferase 1 gene (DNMT1) in malignant T lymphocytes
    • Zhang, Q., H. Y. Wang, A. Woetmann, P. N. Raghunath, N. Odum, and M. A. Wasik. 2006. STAT3 induces transcription of the DNA methyltransferase 1 gene (DNMT1) in malignant T lymphocytes. Blood 108: 1058-1064.
    • (2006) Blood , vol.108 , pp. 1058-1064
    • Zhang, Q.1    Wang, H.Y.2    Woetmann, A.3    Raghunath, P.N.4    Odum, N.5    Wasik, M.A.6
  • 53
    • 18744395503 scopus 로고    scopus 로고
    • STAT3- and DNA methyltransferase 1-mediated epigenetic silencing of SHP-1 tyrosine phosphatase tumor suppressor gene in malignant T lymphocytes
    • Zhang, Q., H. Y. Wang, M. Marzec, P. N. Raghunath, T. Nagasawa, and M. A. Wasik. 2005. STAT3- and DNA methyltransferase 1-mediated epigenetic silencing of SHP-1 tyrosine phosphatase tumor suppressor gene in malignant T lymphocytes. Proc. Natl. Acad. Sci. USA 102: 6948-6953.
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 6948-6953
    • Zhang, Q.1    Wang, H.Y.2    Marzec, M.3    Raghunath, P.N.4    Nagasawa, T.5    Wasik, M.A.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.