Induction of Foxp3 demethylation increases regulatory CD4 +CD25+ T cells and prevents the occurrence of diabetes in mice

Journal of Molecular Medicine

Volumn 87, Issue 12, 2009, Pages 1191-1205

  Zheng, Qanhui ^a,b   Xu, Yamei ^c   Liu, Yanlong ^a,d   Zhang, Baojun ^a,b   Li, Xiaokun ^d   Guo, Feng ^e   Zhao, Yong ^a,b  

^a INSTITUTE OF ZOOLOGY   (China)

^b INSTITUTE OF GEOLOGY AND GEOPHYSICS   (China)

^c BEIJING UNIVERSITY OF CHINESE MEDICINE   (China)

^d WENZHOU MEDICAL UNIVERSITY   (China)

^e THE FIRST AFFILIATED HOSPITAL OF SOOCHOW UNIVERSITY   (China)

Author keywords

Autoimmune disease; Development; Epigenetic; Regulatory T cells; Thymocytes

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; CYCLOPHOSPHAMIDE; TRANSCRIPTION FACTOR FOXP3;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; AUTOIMMUNE DISEASE; CD4+ CD25+ T LYMPHOCYTE; CELL COUNT; CELL CYCLE ARREST; CONTROLLED STUDY; CPG ISLAND; DIABETES MELLITUS; DISEASE COURSE; DNA METHYLATION; FEMALE; GENETIC CONSERVATION; IMMUNOREGULATION; IMMUNOSUPPRESSIVE TREATMENT; INTRON; LYMPHOCYTE COUNT; MOUSE; NONHUMAN; PHENOTYPIC VARIATION; PROMOTER REGION; REGULATORY T LYMPHOCYTE; THYMOCYTE;

ANIMALS; AZACITIDINE; BASE SEQUENCE; CD4-POSITIVE T-LYMPHOCYTES; DIABETES MELLITUS, TYPE 1; FEMALE; FORKHEAD TRANSCRIPTION FACTORS; HUMANS; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; LYMPHOCYTE ACTIVATION; MALE; METHYLATION; MICE; MICE, INBRED C57BL; MICE, INBRED NOD; MOLECULAR SEQUENCE DATA; T-LYMPHOCYTES, REGULATORY; THYMUS GLAND; TREATMENT OUTCOME;

EID: 70949097273     PISSN: 09462716     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00109-009-0530-8     Document Type: Article

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