Upregulated miR-146a expression in peripheral blood mononuclear cells from rheumatoid arthritis patients

Arthritis Research and Therapy

Volumn 10, Issue 4, 2008, Pages

  Pauley, Kaleb M ^a   Satoh, Minoru ^b   Chan, Annie L ^b   Bubb, Michael R ^b   Reeves, Westley H ^b   Chan, Edward K L ^a  

^a UNIVERSITY OF FLORIDA   (United States)

^b UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; BETA INTERFERON; C REACTIVE PROTEIN; CELECOXIB; COLONY STIMULATING FACTOR 1; CYCLOSPORIN; ETANERCEPT; GAMMA INTERFERON; HYDROXYCHLOROQUINE; IBUPROFEN; INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE 1; INTERLEUKIN 10; INTERLEUKIN 12P70; INTERLEUKIN 4; LEFLUNOMIDE; METHOTREXATE; METHYLPREDNISOLONE; MICRORNA; MINOCYCLINE; MONOCYTE CHEMOTACTIC PROTEIN 1; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; NAPROXEN; PREDNISONE; SALAZOSULFAPYRIDINE; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 6; BIOLOGICAL MARKER; INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE; IRAK1 PROTEIN, HUMAN; MIRN146A MICRORNA, HUMAN; MIRN155 MICRORNA, HUMAN; MIRN16 MICRORNA, HUMAN; MIRNLET7 MICRORNA, HUMAN; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DIAGNOSTIC VALUE; DISEASE COURSE; DISEASE MARKER; ERYTHROCYTE SEDIMENTATION RATE; FEMALE; FIBROBLAST; HUMAN; HUMAN CELL; MALE; PATHOGENESIS; PERIPHERAL BLOOD MONONUCLEAR CELL; PROTEIN EXPRESSION; PROTEIN FUNCTION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; RHEUMATOID ARTHRITIS; RNA ISOLATION; SYNOVIUM; TREATMENT OUTCOME; UPREGULATION; BLOOD; CASE CONTROL STUDY; CELL CULTURE; DRUG EFFECT; GENETICS; HOSPITALIZATION; METABOLISM; MIDDLE AGED; MONONUCLEAR CELL; PATHOLOGY; PHYSIOLOGY;

ADULT; AGED; ARTHRITIS, RHEUMATOID; BIOLOGICAL MARKERS; CASE-CONTROL STUDIES; CELLS, CULTURED; FEMALE; HUMANS; INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASES; LEUKOCYTES, MONONUCLEAR; MALE; MICRORNAS; MIDDLE AGED; SEVERITY OF ILLNESS INDEX; TNF RECEPTOR-ASSOCIATED FACTOR 6; TUMOR NECROSIS FACTOR-ALPHA; UP-REGULATION;

EID: 52249094653     PISSN: 14786354     EISSN: 14786362     Source Type: Journal    
DOI: 10.1186/ar2493     Document Type: Article

References (28)

1. Smolen JS Aletaha D Koeller M Weisman MH Emery P New therapies for treatment of rheumatoid arthritis Lancet 2007, 370:1861-1874. 10.1016/ S0140-6736(07)60784-3 17570481
2. Bresnihan B varo-Gracia JM Cobby M Doherty M Domljan Z Emery P Nuki G Pavelka K Rau R Rozman B Watt I Williams B Aitchison R McCabe D Musikic P Treatment of rheumatoid arthritis with recombinant human interleukin-1 receptor antagonist Arthritis Rheum 1998, 41:2196-2204. 10.1002/ 1529-0131(199812)41:12<2196::AID-ART15>3.0.CO;2-2 9870876
3. Lipsky PE Heijde van der DM St Clair EW Furst DE Breedveld FC Kalden JR Smolen JS Weisman M Emery P Feldmann M Harriman GR Maini RN Infliximab and methotrexate in the treatment of rheumatoid arthritis. Anti-Tumor Necrosis Factor Trial in Rheumatoid Arthritis with Concomitant Therapy Study Group N Engl J Med 2000, 343:1594-1602. 10.1056/ NEJM200011303432202 11096166
4. Fabbri M Croce CM Calin GA MicroRNAs Cancer J 2008, 14:1-6. 10.1097/ PPO.0b013e318164145e 18303474
5. Lodish HF Zhou B Liu G Chen CZ Micromanagement of the immune system by microRNAs Nat Rev Immunol 2008, 8:120-130. 10.1038/nri2252 18204468
6. Lewis BP Burge CB Bartel DP Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets Cell 2005, 120:15-20. 10.1016/j.cell.2004.12.035 15652477
7. Cai X Hagedorn CH Cullen BR Human microRNAs are processed from capped, polyadenylated transcripts that can also function as mRNAs RNA 2004, 10:1957-1966. 1370684 15525708 10.1261/rna.7135204
8. Lee Y Kim M Han J Yeom KH Lee S Baek SH Kim VN MicroRNA genes are transcribed by RNA polymerase II EMBO J 2004, 23:4051-4060. 524334 15372072 10.1038/sj.emboj.7600385
9. Denli AM Tops BB Plasterk RH Ketting RF Hannon GJ Processing of primary microRNAs by the Microprocessor complex Nature 2004, 432:231-235. 10.1038/nature03049 15531879
10. Gregory RI Yan KP Amuthan G Chendrimada T Doratotaj B Cooch N Shiekhattar R The Microprocessor complex mediates the genesis of microRNAs Nature 2004, 432:235-240. 10.1038/nature03120 15531877
11. Han J Lee Y Yeom KH Kim YK Jin H Kim VN The Drosha-DGCR8 complex in primary microRNA processing Genes Dev 2004, 18:3016-3027. 535913 15574589 10.1101/gad.1262504
12. Landthaler M Yalcin A Tuschl T The human DiGeorge syndrome critical region gene 8 and its D. melanogaster homolog are required for miRNA biogenesis 2004, 14:2162-2167. 15589161
13. Lee Y Ahn C Han J Choi H Kim J Yim J Lee J Provost P Radmark O Kim S Kim VN The nuclear RNase III Drosha initiates microRNA processing Nature 2003, 425:415-419. 10.1038/nature01957 14508493
14. Du T Zamore PD microPrimer: The biogenesis and function of microRNA Development 2005, 132:4645-4652. 10.1242/dev.02070 16224044
15. Filipowicz W Bhattacharyya SN Sonenberg N Mechanisms of post-transcriptional regulation by microRNAs: Are the answers in sight? Nat Rev Genet 2008, 9:102-114. 10.1038/nrg2290 18197166
16. Liu J Carmell MA Rivas FV Marsden CG Thomson JM Song JJ Hammond SM Joshua-Tor L Hannon GJ Argonaute2 is the catalytic engine of mammalian RNAi Science 2004, 305:1437-1441. 10.1126/science.1102513 15284456
17. Meister G Landthaler M Patkaniowska A Dorsett Y Teng G Tuschl T Human Argonaute2 mediates RNA cleavage targeted by miRNAs and siRNAs Mol Cell 2004, 15:185-197. 10.1016/j.molcel.2004.07.007 15260970
18. Lian S Fritzler MJ Katz J Hamazaki T Terada N Satoh M Chan EKL Small interfering RNA-mediated silencing induces target-dependent assembly of GW/P bodies Mol Biol Cell 2007, 18:3375-3387. 1951753 17596515 10.1091/ mbc.E07-01-0070
19. Pauley KM Eystathioy T Jakymiw A Hamel JC Fritzler MJ Chan EKL Formation of GW bodies is a consequence of miRNA genesis EMBO Rep 2006, 7:904-910. 1559661 16906129 10.1038/sj.embor.7400783
20. O'Connell RM Taganov KD Boldin MP Cheng G Baltimore D MicroRNA-155 is induced during the macrophage inflammatory response Proc Natl Acad Sci USA 2007, 104:1604-1609. 1780072 17242365 10.1073/pnas.0610731104
21. Taganov KD Boldin MP Chang KJ Baltimore D NF-B-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses Proc Natl Acad Sci USA 2006, 103:12481-12486. 1567904 16885212 10.1073/pnas.0605298103
22. Jing Q Huang S Guth S Zarubin T Motoyama A Chen J Di PF Lin SC Gram H Han J Involvement of microRNA in AU-rich element-mediated mRNA instability Cell 2005, 120:623-634. 10.1016/j.cell.2004.12.038 15766526
23. Livak KJ Schmittgen TD Analysis of relative gene expression data using real-time quantitative PCR and the 2-ΔΔCt method Methods 2001, 25:402-408. 10.1006/meth.2001.1262 11846609
24. Eystathioy T Chan EKL Tenenbaum SA Keene JD Griffith K Fritzler MJ A phosphorylated cytoplasmic autoantigen, GW182, associates with a unique population of human mRNAs within novel cytoplasmic speckles Mol Biol Cell 2002, 13:1338-1351. 102273 11950943 10.1091/mbc.01-11-0544
25. Carpenter AE Jones TR Lamprecht MR Clarke C Kang IH Friman O Guertin DA Chang JH Lindquist RA Moffat J Golland P Sabatini DM CellProfiler: Image analysis software for identifying and quantifying cell phenotypes Genome Biol 2006, 7:R100. 1794559 17076895 10.1186/gb-2006-7-10-r100
26. Nakasa T Miyaki S Okubo A Hashimoto M Nishida K Ochi M Asahara H Expression of microRNA-146 in rheumatoid arthritis synovial tissue Arthritis Rheum 2008, 58:1284-1292. 10.1002/art.23429 18438844
27. Stanczyk J Pedrioli DM Brentano F Sanchez-Pernaute O Kolling C Gay RE Detmar M Gay S Kyburz D Altered expression of MicroRNA in synovial fibroblasts and synovial tissue in rheumatoid arthritis Arthritis Rheum 2008, 58:1001-1009. 10.1002/art.23386 18383392
28. Cuschieri J Bulmus V Gourlay D Garcia I Hoffman A Stayton P Maier RV Modulation of macrophage responsiveness to lipopolysaccharide by IRAK-1 manipulation Shock 2004, 21:182-188. 14752294