Resveratrol and cardiovascular health - Promising therapeutic or hopeless illusion?

Pharmacological Research

Volumn 90, Issue , 2014, Pages 88-115

  Tang, Philip Chiu Tsun ^a   Ng, Yam Fung ^a,b   Ho, Susan ^a   Gyda, Michael ^c   Chan, Shun Wan ^a,b  

^a HONG KONG POLYTECHNIC UNIVERSITY   (Hong Kong)

^b State Key Laboratory of Chinese Medicine and Molecular Pharmacology (Incubation)   (China)

^c Life Sciences Multimedia Productions   (United States)

Author keywords

Cardioprotection; Grapes; Polyphenolic SIRT1 Sirtuins Stilbene Polygonum cuspidatum Longevity Caloric restriction Cardiovascular health; Red wine; Resveratrol

Indexed keywords

ADIPONECTIN; CASPASE 8; CHEMOKINE RECEPTOR CX3CR1; ENDOTHELIAL NITRIC OXIDE SYNTHASE; FATTY ACID BINDING PROTEIN; GLUTATHIONE PEROXIDASE 1; GLUTATHIONE TRANSFERASE; HEME OXYGENASE 1; INTERFERON REGULATORY FACTOR 3; INTERLEUKIN 6; INTERLEUKIN 8; MONOCYTE CHEMOTACTIC PROTEIN 1; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PHOSPHOLIPASE D; PROTEIN BAX; PROTEIN BID; PROTEIN P47; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; RESVERATROL; SIRTUIN; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C; STILBENE; THIOBARBITURIC ACID REACTIVE SUBSTANCE; THROMBOXANE B2; TRANSCRIPTION FACTOR FOXO; TRANSCRIPTION FACTOR NRF2; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 6; CARDIOTONIC AGENT; STILBENE DERIVATIVE;

ADIPOGENESIS; ADIPOSE TISSUE; ALLOSTERISM; ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; APOPTOSIS; ATHEROSCLEROSIS; ATHEROSCLEROTIC PLAQUE; CALORIC RESTRICTION; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CELL AGING; CELL DIFFERENTIATION; CELL MIGRATION; CONTROLLED STUDY; DIABETES MELLITUS; DRUG STRUCTURE; DRUG SYNTHESIS; ENDOTHELIAL DYSFUNCTION; HEART MUSCLE FIBROSIS; HEART PROTECTION; HEART VENTRICLE HYPERTROPHY; HYPERTENSION; ILLUSION; LIPID METABOLISM; LIPOGENESIS; LIPOLYSIS; LONGEVITY; LOW DRUG DOSE; MALE; MOUSE; NONHUMAN; OBESITY; OXIDATIVE STRESS; POLYGONUM CUSPIDATUM; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; REPERFUSION INJURY; REVIEW; SIGNAL TRANSDUCTION; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION; UPREGULATION; VASCULAR SMOOTH MUSCLE; VASODILATATION; WEIGHT GAIN; ANIMAL; CARDIOVASCULAR DISEASES; HUMAN;

ANIMALS; CARDIOTONIC AGENTS; CARDIOVASCULAR DISEASES; HUMANS; STILBENES;

EID: 84911889059     PISSN: 10436618     EISSN: 10961186     Source Type: Journal    
DOI: 10.1016/j.phrs.2014.08.001     Document Type: Review

References (332)

1. J. Burns, T. Yokota, H. Ashihara, M.E. Lean, and A. Crozier Plant foods and herbal sources of resveratrol J Agric Food Chem 50 11 2002 3337 3340
2. A.M. Rimando, W. Kalt, J.B. Magee, J. Dewey, and J.R. Ballington Resveratrol, pterostilbene, and piceatannol in vaccinium berries J Agric Food Chem 52 15 2004 4713 4719
3. G. Schroder, J.W. Brown, and J. Schroder Molecular analysis of resveratrol synthase. cDNA, genomic clones and relationship with chalcone synthase Eur J Biochem 172 1 1988 161 169
4. H. Farghali, N. Kutinova Canova, and N. Lekic Resveratrol and related compounds as antioxidants with an allosteric mechanism of action in epigenetic drug targets Physiol Res 62 1 2013 1 13
5. B.P. Hubbard, A.P. Gomes, H. Dai, J. Li, A.W. Case, and T. Considine Evidence for a common mechanism of SIRT1 regulation by allosteric activators Science 339 6124 2013 1216 1219
6. M. Lakshminarasimhan, U. Curth, S. Moniot, S. Mosalaganti, S. Raunser, and C. Steegborn Molecular architecture of the human protein deacetylase Sirt1 and its regulation by AROS and resveratrol Biosci Rep 33 3 2013 e00037
7. M. Gertz, G.T. Nguyen, F. Fischer, B. Suenkel, C. Schlicker, and B. Franzel A molecular mechanism for direct sirtuin activation by resveratrol PLoS ONE 7 11 2012 e49761
8. N.S. Zhdanova, and G.V. Deriagin The relationship between the frequency of participation of acrocentric chromosomes in formation of satellite associations and the duration of human lymphocyte cultivation with phytohemmaglutinin Tsitologiia 17 8 1975 924 929
9. D.A. Sinclair, and L. Guarente Small-molecule allosteric activators of sirtuins Annu Rev Pharmacool Toxicol 54 2014 363 380
10. E. Pantazi, M.A. Zaouali, M. Bejaoui, E. Folch-Puy, H. Ben Abdennebi, and J. Rosello-Catafau Role of sirtuins in ischemia-reperfusion injury World J Gastroenterol 19 43 2013 7594 7602
11. J. Yoshino, C. Conte, L. Fontana, B. Mittendorfer, S. Imai, and K.B. Schechtman Resveratrol supplementation does not improve metabolic function in nonobese women with normal glucose tolerance Cell Metab 16 5 2012 658 664
12. R.H. Wong, A.M. Coates, J.D. Buckley, and P.R. Howe Evidence for circulatory benefits of resveratrol in humans Ann NY Acad Sci 1290 2013 52 58
13. E.L. Wightman, J.L. Reay, C.F. Haskell, G. Williamson, T.P. Dew, and D.O. Kennedy Effects of resveratrol alone or in combination with piperine on cerebral blood flow parameters and cognitive performance in human subjects: a randomised, double-blind, placebo-controlled, cross-over investigation Br J Nutr 112 2 2014 203 213
14. S. Timmers, M.K. Hesselink, and P. Schrauwen Therapeutic potential of resveratrol in obesity and type 2 diabetes: new avenues for health benefits? Ann NY Acad Sci 1290 2013 83 89
15. A. Soare, E.P. Weiss, J.O. Holloszy, and L. Fontana Multiple dietary supplements do not affect metabolic and cardio-vascular health Aging (Milano) 6 2 2014 149 157
16. S.M. Lee, H. Yang, D.M. Tartar, B. Gao, X. Luo, and S.Q. Ye Prevention and treatment of diabetes with resveratrol in a non-obese mouse model of type 1 diabetes Diabetologia 54 5 2011 1136 1146
17. E. Calleri, G. Pochetti, K.S. Dossou, A. Laghezza, R. Montanari, and D. Capelli Resveratrol and its metabolites bind to PPARs ChemBioChem 15 8 2014 1154 1160
18. M. Bjorklund, J. Roos, V. Gogvadze, and M. Shoshan Resveratrol induces SIRT1- and energy-stress-independent inhibition of tumor cell regrowth after low-dose platinum treatment Cancer Chemother Pharmacol 68 6 2011 1459 1467
19. D.V. Tillu, O.K. Melemedjian, M.N. Asiedu, N. Qu, M. De Felice, and G. Dussor Resveratrol engages AMPK to attenuate ERK and mTOR signaling in sensory neurons and inhibits incision-induced acute and chronic pain Mol Pain 8 2012 5
20. B. Annabi, S. Lord-Dufour, A. Vezina, and R. Beliveau Resveratrol targeting of carcinogen-induced brain endothelial cell inflammation biomarkers MMP-9 and COX-2 is Sirt1-independent Drug Target Insights 6 2012 1 11
21. A.L. Widlund, J.A. Baur, and O. Vang mTOR: more targets of resveratrol? Expert Rev Mol Med 15 2013 e10
22. P. Poirier, T.D. Giles, G.A. Bray, Y. Hong, J.S. Stern, and F.X. Pi-Sunyer Obesity and cardiovascular disease: pathophysiology, evaluation, and effect of weight loss Arterioscler Thromb Vasc Biol 26 5 2006 968 976
23. S. Rayalam, M.A. Della-Fera, and C.A. Baile Phytochemicals and regulation of the adipocyte life cycle J Nutr Biochem 19 11 2008 717 726
24. L. Bai, W.J. Pang, Y.J. Yang, and G.S. Yang Modulation of Sirt1 by resveratrol and nicotinamide alters proliferation and differentiation of pig preadipocytes Mol Cell Biochem 307 1-2 2008 129 140
25. C.M. Backesjo, Y. Li, U. Lindgren, and L.A. Haldosen Activation of Sirt1 decreases adipocyte formation during osteoblast differentiation of mesenchymal stem cells J Bone Miner Res 21 7 2006 993 1002
26. F. Picard, M. Kurtev, N. Chung, A. Topark-Ngarm, T. Senawong, and R. Machado De Oliveira Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma Nature 429 6993 2004 771 776
27. S. Chen, Z. Li, W. Li, Z. Shan, and W. Zhu Resveratrol inhibits cell differentiation in 3T3-L1 adipocytes via activation of AMPK Can J Physiol Pharmacol 89 11 2011 793 799
28. C.B. Williams, and B.J. Gurd Skeletal muscle SIRT1 and the genetics of metabolic health: therapeutic activation by pharmaceuticals and exercise Appl Clin Genet 5 2012 81 91
29. M.T. Borra, B.C. Smith, and J.M. Denu Mechanism of human SIRT1 activation by resveratrol J Biol Chem 280 17 2005 17187 17195
30. J.Y. Kwon, S.G. Seo, S. Yue, J.X. Cheng, K.W. Lee, and K.H. Kim An inhibitory effect of resveratrol in the mitotic clonal expansion and insulin signaling pathway in the early phase of adipogenesis Nutr Res 32 8 2012 607 616
31. K. Szkudelska, L. Nogowski, and T. Szkudelski Resveratrol, a naturally occurring diphenolic compound, affects lipogenesis, lipolysis and the antilipolytic action of insulin in isolated rat adipocytes J Steroid Biochem Mol Biol 113 1-2 2009 17 24
32. M.S. Brown, and J.L. Goldstein The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor Cell 89 3 1997 331 340
33. B. Ponugoti, D.H. Kim, Z. Xiao, Z. Smith, J. Miao, and M. Zang SIRT1 deacetylates and inhibits SREBP-1C activity in regulation of hepatic lipid metabolism J Biol Chem 285 44 2010 33959 33970
34. T. Shan, Y. Wang, T. Wu, J. Guo, J. Liu, and J. Feng Porcine adipose triglyceride lipase complementary deoxyribonucleic acid clone, expression pattern, and regulation by resveratrol J Anim Sci 86 8 2008 1781 1788
35. A. Lasa, M. Schweiger, P. Kotzbeck, I. Churruca, E. Simon, and R. Zechner Resveratrol regulates lipolysis via adipose triglyceride lipase J Nutr Biochem 23 4 2012 379 384
36. I. Mader, M. Wabitsch, K.M. Debatin, P. Fischer-Posovszky, and S. Fulda Identification of a novel proapoptotic function of resveratrol in fat cells: SIRT1-independent sensitization to TRAIL-induced apoptosis FASEB J 24 6 2010 1997 2009
37. P. Fischer-Posovszky, V. Kukulus, D. Tews, T. Unterkircher, K.M. Debatin, and S. Fulda Resveratrol regulates human adipocyte number and function in a Sirt1-dependent manner Am J Clin Nutr 92 1 2010 5 15
38. L. Rivera, R. Moron, A. Zarzuelo, and M. Galisteo Long-term resveratrol administration reduces metabolic disturbances and lowers blood pressure in obese Zucker rats Biochem Pharmacol 77 6 2009 1053 1063
39. G.C. Yen, Y.C. Chen, W.T. Chang, and C.L. Hsu Effects of polyphenolic compounds on tumor necrosis factor-alpha (TNF-alpha)-induced changes of adipokines and oxidative stress in 3T3-L1 adipocytes J Agric Food Chem 59 2 2011 546 551
40. J. Mercader, A. Palou, and M.L. Bonet Resveratrol enhances fatty acid oxidation capacity and reduces resistin and retinol-binding protein 4 expression in white adipocytes J Nutr Biochem 22 9 2011 828 834
41. J.A. Finegold, P. Asaria, and D.P. Francis Mortality from ischaemic heart disease by country, region, and age: statistics from World Health Organisation and United Nations Int J Cardiol 168 2 2013 934 945
42. S.V. Penumathsa, M. Thirunavukkarasu, S. Koneru, B. Juhasz, L. Zhan, and R. Pant Statin and resveratrol in combination induces cardioprotection against myocardial infarction in hypercholesterolemic rat J Mol Cell Cardiol 42 3 2007 508 516
43. H. Sasaki, S. Fukuda, H. Otani, L. Zhu, G. Yamaura, and R.M. Engelman Hypoxic preconditioning triggers myocardial angiogenesis: a novel approach to enhance contractile functional reserve in rat with myocardial infarction J Mol Cell Cardiol 34 3 2002 335 348
44. S. Kaga, L. Zhan, M. Matsumoto, and N. Maulik Resveratrol enhances neovascularization in the infarcted rat myocardium through the induction of thioredoxin-1, heme oxygenase-1 and vascular endothelial growth factor J Mol Cell Cardiol 39 5 2005 813 822
45. X.B. Wang, J. Huang, J.G. Zou, E.B. Su, Q.J. Shan, and Z.J. Yang Effects of resveratrol on number and activity of endothelial progenitor cells from human peripheral blood Clin Exp Pharmacol Physiol 34 11 2007 1109 1115
46. P. Mukhopadhyay, S. Mukherjee, K. Ahsan, A. Bagchi, P. Pacher, and D.K. Das Restoration of altered microRNA expression in the ischemic heart with resveratrol PLoS ONE 5 12 2010 e15705
47. S. Lecour Activation of the protective survivor activating factor enhancement (SAFE) pathway against reperfusion injury: does it go beyond the RISK pathway? J Mol Cell Cardiol 47 1 2009 32 40
48. K.T. Lamont, S. Somers, L. Lacerda, L.H. Opie, and S. Lecour Is red wine a SAFE sip away from cardioprotection? Mechanisms involved in resveratrol- and melatonin-induced cardioprotection J Pineal Res 50 4 2011 374 380
49. K. Shinmura, K. Tamaki, M. Sano, N. Nakashima-Kamimura, A.M. Wolf, and T. Amo Caloric restriction primes mitochondria for ischemic stress by deacetylating specific mitochondrial proteins of the electron transport chain Circ Res 109 4 2011 396 406
50. J.B. Pillai, M. Chen, S.B. Rajamohan, S. Samant, V.B. Pillai, and M. Gupta Activation of SIRT1, a class III histone deacetylase, contributes to fructose feeding-mediated induction of the alpha-myosin heavy chain expression Am J Physiol Heart Circ Physiol 294 3 2008 H1388 H1397
51. C.J. Chen, W. Yu, Y.C. Fu, X. Wang, J.L. Li, and W. Wang Resveratrol protects cardiomyocytes from hypoxia-induced apoptosis through the SIRT1-FoxO1 pathway Biochem Biophys Res Commun 378 3 2009 389 393
52. M. Becatti, N. Taddei, C. Cecchi, N. Nassi, P.A. Nassi, and C. Fiorillo SIRT1 modulates MAPK pathways in ischemic-reperfused cardiomyocytes Cell Mol Life Sci 69 13 2012 2245 2260
53. J. James, L. Martin, M. Krenz, C. Quatman, F. Jones, and R. Klevitsky Forced expression of alpha-myosin heavy chain in the rabbit ventricle results in cardioprotection under cardiomyopathic conditions Circulation 111 18 2005 2339 2346
54. D. Clark, U.I. Tuor, R. Thompson, A. Institoris, A. Kulynych, and X. Zhang Protection against recurrent stroke with resveratrol: endothelial protection PLoS ONE 7 10 2012 e47792
55. A.M. Walters, G.A. Porter Jr., and P.S. Brookes Mitochondria as a drug target in ischemic heart disease and cardiomyopathy Circ Res 111 9 2012 1222 1236
56. J. Xi, H. Wang, R.A. Mueller, E.A. Norfleet, and Z. Xu Mechanism for resveratrol-induced cardioprotection against reperfusion injury involves glycogen synthase kinase 3beta and mitochondrial permeability transition pore Eur J Pharmacol 604 1-3 2009 111 116
57. R.R. Russell 3rd, J. Li, D.L. Coven, M. Pypaert, C. Zechner, and M. Palmeri AMP-activated protein kinase mediates ischemic glucose uptake and prevents postischemic cardiac dysfunction, apoptosis, and injury J Clin Invest 114 4 2004 495 503
58. H. Ma, J. Wang, D.P. Thomas, C. Tong, L. Leng, and W. Wang Impaired macrophage migration inhibitory factor-AMP-activated protein kinase activation and ischemic recovery in the senescent heart Circulation 122 3 2010 282 292
59. S. Shigematsu, S. Ishida, M. Hara, N. Takahashi, H. Yoshimatsu, and T. Sakata Resveratrol, a red wine constituent polyphenol, prevents superoxide-dependent inflammatory responses induced by ischemia/reperfusion, platelet-activating factor, or oxidants Free Radic Biol Med 34 7 2003 810 817
60. C. Zhang, G. Lin, W. Wan, X. Li, B. Zeng, and B. Yang Resveratrol, a polyphenol phytoalexin, protects cardiomyocytes against anoxia/reoxygenation injury via the TLR4/NF-kappaB signaling pathway Int J Mol Med 29 4 2012 557 563
61. M.J. Wang, H.M. Huang, S.J. Hsieh, K.C. Jeng, and J.S. Kuo Resveratrol inhibits interleukin-6 production in cortical mixed glial cells under hypoxia/hypoglycemia followed by reoxygenation J Neuroimmunol 112 1-2 2001 28 34
62. N. Gurusamy, I. Lekli, S. Mukherjee, D. Ray, M.K. Ahsan, and M. Gherghiceanu Cardioprotection by resveratrol: a novel mechanism via autophagy involving the mTORC2 pathway Cardiovasc Res 86 1 2010 103 112
63. L.M. Hung, M.J. Su, and J.K. Chen Resveratrol protects myocardial ischemia-reperfusion injury through both NO-dependent and NO-independent mechanisms Free Radic Biol Med 36 6 2004 774 781
64. M. Kitakaze, K. Node, T. Minamino, H. Kosaka, Y. Shinozaki, and H. Mori Role of nitric oxide in regulation of coronary blood flow during myocardial ischemia in dogs J Am Coll Cardiol 27 7 1996 1804 1812
65. O.A. Carretero, and S. Oparil Essential hypertension. Part I: definition and etiology Circulation 101 3 2000 329 335
66. M. Law, N. Wald, and J. Morris Lowering blood pressure to prevent myocardial infarction and stroke: a new preventive strategy Health Technol Assess 7 31 2003 1 94
67. K.L. Chambliss, and P.W. Shaul Estrogen modulation of endothelial nitric oxide synthase Endocr Rev 23 5 2002 665 686
68. J.P. Cooke, E. Rossitch Jr., N.A. Andon, J. Loscalzo, and V.J. Dzau Flow activates an endothelial potassium channel to release an endogenous nitrovasodilator J Clin Invest 88 5 1991 1663 1671
69. V. Calderone, A. Martelli, L. Testai, E. Martinotti, and M.C. Breschi Functional contribution of the endothelial component to the vasorelaxing effect of resveratrol and NS 1619, activators of the large-conductance calcium-activated potassium channels Naunyn Schmiedebergs Arch Pharmacol 375 1 2007 73 80
70. C.M. Klinge, K.A. Blankenship, K.E. Risinger, S. Bhatnagar, E.L. Noisin, and W.K. Sumanasekera Resveratrol and estradiol rapidly activate MAPK signaling through estrogen receptors alpha and beta in endothelial cells J Biol Chem 280 9 2005 7460 7468
71. C.M. Klinge, N.S. Wickramasinghe, M.M. Ivanova, and S.M. Dougherty Resveratrol stimulates nitric oxide production by increasing estrogen receptor alpha-Src-caveolin-1 interaction and phosphorylation in human umbilical vein endothelial cells FASEB J 22 7 2008 2185 2197
72. Q. Xu, X. Hao, Q. Yang, and L. Si Resveratrol prevents hyperglycemia-induced endothelial dysfunction via activation of adenosine monophosphate-activated protein kinase Biochem Biophys Res Commun 388 2 2009 389 394
73. N. Xia, S. Strand, F. Schlufter, D. Siuda, G. Reifenberg, and H. Kleinert Role of SIRT1 and FOXO factors in eNOS transcriptional activation by resveratrol Nitric Oxide 32 2013 29 35
74. U. Forstermann, and H. Li Therapeutic effect of enhancing endothelial nitric oxide synthase (eNOS) expression and preventing eNOS uncoupling Br J Pharmacol 164 2 2011 213 223
75. A. Carrizzo, A. Puca, A. Damato, M. Marino, E. Franco, and F. Pompeo Resveratrol improves vascular function in patients with hypertension and dyslipidemia by modulating NO metabolism Hypertension 62 2 2013 359 366
76. N. Xia, A. Daiber, A. Habermeier, E.I. Closs, T. Thum, and G. Spanier Resveratrol reverses endothelial nitric-oxide synthase uncoupling in apolipoprotein E knockout mice J Pharmacol Exp Ther 335 1 2010 149 154
77. A.G. Rajapakse, G. Yepuri, J.M. Carvas, S. Stein, C.M. Matter, and I. Scerri Hyperactive S6K1 mediates oxidative stress and endothelial dysfunction in aging: inhibition by resveratrol PLoS ONE 6 4 2011 e19237
78. G. Arunachalam, H. Yao, I.K. Sundar, S. Caito, and I. Rahman SIRT1 regulates oxidant- and cigarette smoke-induced eNOS acetylation in endothelial cells: role of resveratrol Biochem Biophys Res Commun 393 1 2010 66 72
79. A.M. El-Mowafy, M. Alkhalaf, and S.M. Jaffal Nongenomic activation of the GC-A enzyme by resveratrol and estradiol downstream from membrane estrogen receptors in human coronary arterial cells Nutr Metab Cardiovasc Dis 17 7 2007 508 516
80. A.M. El-Mowafy Resveratrol activates membrane-bound guanylyl cyclase in coronary arterial smooth muscle: a novel signaling mechanism in support of coronary protection Biochem Biophys Res Commun 291 5 2002 1218 1224
81. M. Shen, L. Zhao, R.X. Wu, S.Q. Yue, and J.M. Pei The vasorelaxing effect of resveratrol on abdominal aorta from rats and its underlying mechanisms Vascul Pharmacol 58 1-2 2013 64 70
82. H.F. Li, Z.F. Tian, X.Q. Qiu, J.X. Wu, P. Zhang, and Z.J. Jia A study of mechanisms involved in vasodilatation induced by resveratrol in isolated porcine coronary artery Physiol Res 55 4 2006 365 372
83. M. Morgado, E. Cairrao, A.J. Santos-Silva, and I. Verde Cyclic nucleotide-dependent relaxation pathways in vascular smooth muscle Cell Mol Life Sci 69 2 2012 247 266
84. R. Miyazaki, T. Ichiki, T. Hashimoto, K. Inanaga, I. Imayama, and J. Sadoshima SIRT1, a longevity gene, downregulates angiotensin II type 1 receptor expression in vascular smooth muscle cells Arterioscler Thromb Vasc Biol 28 7 2008 1263 1269
85. S. Higuchi, H. Ohtsu, H. Suzuki, H. Shirai, G.D. Frank, and S. Eguchi Angiotensin II signal transduction through the AT1 receptor: novel insights into mechanisms and pathophysiology Clin Sci (Lond) 112 8 2007 417 428
86. J.D. Kakisis, C.D. Liapis, and B.E. Sumpio Effects of cyclic strain on vascular cells Endothelium 11 1 2004 17 28
87. T.H. Cheng, N.L. Shih, S.Y. Chen, S.H. Loh, P.Y. Cheng, and C.S. Tsai Reactive oxygen species mediate cyclic strain-induced endothelin-1 gene expression via Ras/Raf/extracellular signal-regulated kinase pathway in endothelial cells J Mol Cell Cardiol 33 10 2001 1805 1814
88. J.C. Liu, J.J. Chen, P. Chan, C.F. Cheng, and T.H. Cheng Inhibition of cyclic strain-induced endothelin-1 gene expression by resveratrol Hypertension 42 6 2003 1198 1205
89. D.E. Stec, K. Ishikawa, D. Sacerdoti, and N.G. Abraham The emerging role of heme oxygenase and its metabolites in the regulation of cardiovascular function Int J Hypertens 2012 2012 593530
90. S.H. Juan, T.H. Cheng, H.C. Lin, Y.L. Chu, and W.S. Lee Mechanism of concentration-dependent induction of heme oxygenase-1 by resveratrol in human aortic smooth muscle cells Biochem Pharmacol 69 1 2005 41 48
91. H.M. Huang, Y.C. Liang, T.H. Cheng, C.H. Chen, and S.H. Juan Potential mechanism of blood vessel protection by resveratrol, a component of red wine Ann N Y Acad Sci 1042 2005 349 356
92. K. Sugamura, and J.F. Keaney Jr. Reactive oxygen species in cardiovascular disease Free Rad Biol Med 51 5 2011 978 992
93. M.Y. Shen, G. Hsiao, C.L. Liu, T.H. Fong, K.H. Lin, and D.S. Chou Inhibitory mechanisms of resveratrol in platelet activation: pivotal roles of p38 MAPK and NO/cyclic GMP Br J Haematol 139 3 2007 475 485
94. A. Csiszar, N. Labinskyy, S. Olson, J.T. Pinto, S. Gupte, and J.M. Wu Resveratrol prevents monocrotaline-induced pulmonary hypertension in rats Hypertension 54 3 2009 668 675
95. G. Spanier, H. Xu, N. Xia, S. Tobias, S. Deng, and L. Wojnowski Resveratrol reduces endothelial oxidative stress by modulating the gene expression of superoxide dismutase 1 (SOD1), glutathione peroxidase 1 (GPx1) and NADPH oxidase subunit (Nox4) J Physiol Pharmacol 60 Suppl. 4 2009 111 116
96. M.J. Zarzuelo, R. Lopez-Sepulveda, M. Sanchez, M. Romero, M. Gomez-Guzman, and Z. Ungvary SIRT1 inhibits NADPH oxidase activation and protects endothelial function in the rat aorta: implications for vascular aging Biochem Pharmacol 85 9 2013 1288 1296
97. S.E. Chow, Y.C. Hshu, J.S. Wang, and J.K. Chen Resveratrol attenuates oxLDL-stimulated NADPH oxidase activity and protects endothelial cells from oxidative functional damages J Appl Physiol 102 4 2007 1520 1527
98. M. Tanno, A. Kuno, T. Yano, T. Miura, S. Hisahara, and S. Ishikawa Induction of manganese superoxide dismutase by nuclear translocation and activation of SIRT1 promotes cell survival in chronic heart failure J Biol Chem 285 11 2010 8375 8382
99. A. van der Horst, L.G. Tertoolen, L.M. de Vries-Smits, R.A. Frye, R.H. Medema, and B.M. Burgering FOXO4 is acetylated upon peroxide stress and deacetylated by the longevity protein hSir2(SIRT1) J Biol Chem 279 28 2004 28873 28879
100. A.R. Subauste, and C.F. Burant Role of FoxO1 in FFA-induced oxidative stress in adipocytes Am J Physiol Endocrinol Metab 293 1 2007 E159 E164
101. Z. Ungvari, Z. Bagi, A. Feher, F.A. Recchia, W.E. Sonntag, and K. Pearson Resveratrol confers endothelial protection via activation of the antioxidant transcription factor Nrf2 Am J Physiol Heart Circ Physiol 299 1 2010 H18 H24
102. J.J. Verschuren, S. Trompet, J.A. Wessels, H.J. Guchelaar, M.P. de Maat, and M.L. Simoons A systematic review on pharmacogenetics in cardiovascular disease: is it ready for clinical application? Eur Heart J 33 2 2012 165 175
103. H.M. Zbikowska, and B. Olas Antioxidants with carcinostatic activity (resveratrol, vitamin E and selenium) in modulation of blood platelet adhesion J Physiol Pharmacol 51 3 2000 513 520
104. N.C. Kaneider, B. Mosheimer, N. Reinisch, J.R. Patsch, and C.J. Wiedermann Inhibition of thrombin-induced signaling by resveratrol and quercetin: effects on adenosine nucleotide metabolism in endothelial cells and platelet-neutrophil interactions Thromb Res 114 3 2004 185 194
105. C.C. Wu, C.I. Wu, W.Y. Wang, and Y.C. Wu Low concentrations of resveratrol potentiate the antiplatelet effect of prostaglandins Planta Med 73 5 2007 439 443
106. B. Olas, B. Wachowicz, J. Saluk-Juszczak, T. Zielinski, W. Kaca, and A. Buczynski Antioxidant activity of resveratrol in endotoxin-stimulated blood platelets Cell Biol Toxicol 17 2 2001 117 125
107. C.R. Pace-Asciak, S. Hahn, E.P. Diamandis, G. Soleas, and D.M. Goldberg The red wine phenolics trans-resveratrol and quercetin block human platelet aggregation and eicosanoid synthesis: implications for protection against coronary heart disease Clin Chim Acta 235 2 1995 207 219
108. K.H. Lin, G. Hsiao, C.M. Shih, D.S. Chou, and J.R. Sheu Mechanisms of resveratrol-induced platelet apoptosis Cardiovasc Res 83 3 2009 575 585
109. S.J. Shattil, and L.F. Brass Induction of the fibrinogen receptor on human platelets by intracellular mediators J Biol Chem 262 3 1987 992 1000
110. B. Olas, B. Wachowicz, H. Holmsen, and M.H. Fukami Resveratrol inhibits polyphosphoinositide metabolism in activated platelets Biochim Biophys Acta 1714 2 2005 125 133
111. Y. Yang, X. Wang, L. Zhang, H. An, and Z. Zao Inhibitory effects of resveratrol on platelet activation induced by thromboxane a(2) receptor agonist in human platelets Am J Chin Med 39 1 2011 145 159
112. Y.M. Yang, J.Z. Chen, X.X. Wang, S.J. Wang, H. Hu, and H.Q. Wang Resveratrol attenuates thromboxane A2 receptor agonist-induced platelet activation by reducing phospholipase C activity Eur J Pharmacol 583 1 2008 148 155
113. Y. Dobrydneva, R.L. Williams, and P.F. Blackmore trans-Resveratrol inhibits calcium influx in thrombin-stimulated human platelets Br J Pharmacol 128 1 1999 149 157
114. Y. Dobrydneva, R.L. Williams, G.Z. Morris, and P.F. Blackmore Dietary phytoestrogens and their synthetic structural analogues as calcium channel blockers in human platelets J Cardiovasc Pharmacol 40 3 2002 399 410
115. R.C. Forde, and D.J. Fitzgerald Reactive oxygen species and platelet activation in reperfusion injury Circulation 95 4 1997 787 789
116. P. Libby Inflammation and cardiovascular disease mechanisms Am J Clin Nutr 83 2 2006 456S 460S
117. J. Martinez, and J.J. Moreno Effect of resveratrol, a natural polyphenolic compound, on reactive oxygen species and prostaglandin production Biochem Pharmacol 59 7 2000 865 870
118. J.M. Leiro, M. Varela, M.C. Piazzon, J.A. Arranz, M. Noya, and J. Lamas The anti-inflammatory activity of the polyphenol resveratrol may be partially related to inhibition of tumour necrosis factor-alpha (TNF-alpha) pre-mRNA splicing Mol Immunol 47 5 2010 1114 1120
119. T.M. Poolman, L.L. Ng, P.B. Farmer, and M.M. Manson Inhibition of the respiratory burst by resveratrol in human monocytes: correlation with inhibition of PI3K signaling Free Radic Biol Med 39 1 2005 118 132
120. M. Holmes-McNary, and A.S. Baldwin Jr. Chemopreventive properties of trans-resveratrol are associated with inhibition of activation of the IkappaB kinase Cancer Res 60 13 2000 3477 3483
121. S.P. Khanapure, D.S. Garvey, D.R. Janero, and L.G. Letts Eicosanoids in inflammation: biosynthesis, pharmacology, and therapeutic frontiers Curr Top Med Chem 7 3 2007 311 340
122. J. Tou, and C. Urbizo Resveratrol inhibits the formation of phosphatidic acid and diglyceride in chemotactic peptide- or phorbol ester-stimulated human neutrophils Cell Signal 13 3 2001 191 197
123. S. Kofler, T. Nickel, and M. Weis Role of cytokines in cardiovascular diseases: a focus on endothelial responses to inflammation Clin Sci (Lond) 108 3 2005 205 213
124. C.O. Yi, B.T. Jeon, H.J. Shin, E.A. Jeong, K.C. Chang, and J.E. Lee Resveratrol activates AMPK and suppresses LPS-induced NF-kappaB-dependent COX-2 activation in RAW 264.7 macrophage cells Anat Cell Biol 44 3 2011 194 203
125. A.A. Qureshi, X.Q. Guan, J.C. Reis, C.J. Papasian, S. Jabre, and D.C. Morrison Inhibition of nitric oxide and inflammatory cytokines in LPS-stimulated murine macrophages by resveratrol, a potent proteasome inhibitor Lipids Health Dis 11 2012 76
126. S.H. Tsai, S.Y. Lin-Shiau, and J.K. Lin Suppression of nitric oxide synthase and the down-regulation of the activation of NFkappaB in macrophages by resveratrol Br J Pharmacol 126 3 1999 673 680
127. J. Olholm, S.K. Paulsen, K.B. Cullberg, B. Richelsen, and S.B. Pedersen Anti-inflammatory effect of resveratrol on adipokine expression and secretion in human adipose tissue explants Int J Obes (Lond) 34 10 2010 1546 1553
128. J. Niu, and P.E. Kolattukudy Role of MCP-1 in cardiovascular disease: molecular mechanisms and clinical implications Clin Sci (Lond) 117 3 2009 95 109
129. J.P. Cullen, D. Morrow, Y. Jin, B. Curley, A. Robinson, and J.V. Sitzmann Resveratrol, a polyphenolic phytostilbene, inhibits endothelial monocyte chemotactic protein-1 synthesis and secretion J Vasc Res 44 1 2007 75 84
130. J. Zhu, W. Yong, X. Wu, Y. Yu, J. Lv, and C. Liu Anti-inflammatory effect of resveratrol on TNF-alpha-induced MCP-1 expression in adipocytes Biochem Biophys Res Commun 369 2 2008 471 477
131. K. Van der Heiden, S. Cuhlmann, A. Luong le, M. Zakkar, and P.C. Evans Role of nuclear factor kappaB in cardiovascular health and disease Clin Sci (Lond) 118 10 2010 593 605
132. S.K. Manna, A. Mukhopadhyay, and B.B. Aggarwal Resveratrol suppresses TNF-induced activation of nuclear transcription factors NF-kappa B, activator protein-1, and apoptosis: potential role of reactive oxygen intermediates and lipid peroxidation J Immunol 164 12 2000 6509 6519
133. S.M. Grundy, I.J. Benjamin, G.L. Burke, A. Chait, R.H. Eckel, and B.V. Howard Diabetes and cardiovascular disease: a statement for healthcare professionals from the American Heart Association Circulation 100 10 1999 1134 1146
134. S. Koren, and I.G. Fantus Inhibition of the protein tyrosine phosphatase PTP1B: potential therapy for obesity, insulin resistance and type-2 diabetes mellitus Best Pract Res Clin Endocrinol Metab 21 4 2007 621 640
135. C. Sun, F. Zhang, X. Ge, T. Yan, X. Chen, and X. Shi SIRT1 improves insulin sensitivity under insulin-resistant conditions by repressing PTP1B Cell Metab 6 4 2007 307 319
136. L. Kang, W. Heng, A. Yuan, L. Baolin, and H. Fang Resveratrol modulates adipokine expression and improves insulin sensitivity in adipocytes: relative to inhibition of inflammatory responses Biochimie 92 7 2010 789 796
137. A. Yadav, M.A. Kataria, and V. Saini Role of leptin and adiponectin in insulin resistance Clin Chim Acta 417 2013 80 84
138. A. Rosenow, J.P. Noben, J. Jocken, S. Kallendrusch, P. Fischer-Posovszky, and E.C. Mariman Resveratrol-induced changes of the human adipocyte secretion profile J Proteome Res 11 9 2012 4733 4743
139. A. Wang, M. Liu, X. Liu, L.Q. Dong, R.D. Glickman, and T.J. Slaga Up-regulation of adiponectin by resveratrol: the essential roles of the Akt/FOXO1 and AMP-activated protein kinase signaling pathways and DsbA-L J Biol Chem 286 1 2011 60 66
140. G. Ramadori, L. Gautron, T. Fujikawa, C.R. Vianna, J.K. Elmquist, and R. Coppari Central administration of resveratrol improves diet-induced diabetes Endocrinology 150 12 2009 5326 5333
141. C.M. Knight, R. Gutierrez-Juarez, T.K. Lam, I. Arrieta-Cruz, L. Huang, and G. Schwartz Mediobasal hypothalamic SIRT1 is essential for resveratrol's effects on insulin action in rats Diabetes 60 11 2011 2691 2700
142. S. Frojdo, C. Durand, L. Molin, A.L. Carey, A. El-Osta, and B.A. Kingwell Phosphoinositide 3-kinase as a novel functional target for the regulation of the insulin signaling pathway by SIRT1 Mol Cell Endocrinol 335 2 2011 166 176
143. V. Aguirre, E.D. Werner, J. Giraud, Y.H. Lee, S.E. Shoelson, and M.F. White Phosphorylation of Ser307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin action J Biol Chem 277 2 2002 1531 1537
144. C.E. Park, M.J. Kim, J.H. Lee, B.I. Min, H. Bae, and W. Choe Resveratrol stimulates glucose transport in C2C12 myotubes by activating AMP-activated protein kinase Exp Mol Med 39 2 2007 222 229
145. Z. Tan, L.J. Zhou, P.W. Mu, S.P. Liu, S.J. Chen, and X.D. Fu Caveolin-3 is involved in the protection of resveratrol against high-fat-diet-induced insulin resistance by promoting GLUT4 translocation to the plasma membrane in skeletal muscle of ovariectomized rats J Nutr Biochem 23 12 2012 1716 1724
146. G.M. Do, U.J. Jung, H.J. Park, E.Y. Kwon, S.M. Jeon, and R.A. McGregor Resveratrol ameliorates diabetes-related metabolic changes via activation of AMP-activated protein kinase and its downstream targets in db/db mice Mol Nutr Food Res 56 8 2012 1282 1291
147. T.C. Chi, W.P. Chen, T.L. Chi, T.F. Kuo, S.S. Lee, and J.T. Cheng Phosphatidylinositol-3-kinase is involved in the antihyperglycemic effect induced by resveratrol in streptozotocin-induced diabetic rats Life Sci 80 18 2007 1713 1720
148. D.M. Breen, T. Sanli, A. Giacca, and E. Tsiani Stimulation of muscle cell glucose uptake by resveratrol through sirtuins and AMPK Biochem Biophys Res Commun 374 1 2008 117 122
149. A.S. Rajan, L. Aguilar-Bryan, D.A. Nelson, G.C. Yaney, W.H. Hsu, and D.L. Kunze Ion channels and insulin secretion Diabetes Care 13 3 1990 340 363
150. M.W. Roe, J.F. Worley 3rd, A.A. Mittal, A. Kuznetsov, S. DasGupta, and R.J. Mertz Expression and function of pancreatic beta-cell delayed rectifier K+ channels. Role in stimulus-secretion coupling J Biol Chem 271 50 1996 32241 32246
151. W.P. Chen, T.C. Chi, L.M. Chuang, and M.J. Su Resveratrol enhances insulin secretion by blocking K(ATP) and K(V) channels of beta cells Eur J Pharmacol 568 1-3 2007 269 277
152. L. Vetterli, T. Brun, L. Giovannoni, D. Bosco, and P. Maechler Resveratrol potentiates glucose-stimulated insulin secretion in INS-1E beta-cells and human islets through a SIRT1-dependent mechanism J Biol Chem 286 8 2011 6049 6060
153. C. Silan The effects of chronic resveratrol treatment on vascular responsiveness of streptozotocin-induced diabetic rats Biol Pharm Bull 31 5 2008 897 902
154. J. Yang, N. Wang, J. Li, J. Zhang, and P. Feng Effects of resveratrol on NO secretion stimulated by insulin and its dependence on SIRT1 in high glucose cultured endothelial cells Endocrine 37 2 2010 365 372
155. M.F. Lopes-Virella, and G. Virella Immune mechanisms of atherosclerosis in diabetes mellitus Diabetes 41 Suppl. 2 1992 86 91
156. S.W. Kim, C.E. Kim, and M.H. Kim Flavonoids inhibit high glucose-induced up-regulation of ICAM-1 via the p38 MAPK pathway in human vein endothelial cells Biochem Biophys Res Commun 415 4 2011 602 607
157. Z. Ungvari, N. Labinskyy, P. Mukhopadhyay, J.T. Pinto, Z. Bagi, and P. Ballabh Resveratrol attenuates mitochondrial oxidative stress in coronary arterial endothelial cells Am J Physiol Heart Circ Physiol 297 5 2009 H1876 H1881
158. J. Hou, Z.Z. Chong, Y.C. Shang, and K. Maiese Early apoptotic vascular signaling is determined by Sirt1 through nuclear shuttling, forkhead trafficking, bad, and mitochondrial caspase activation Curr Neurovasc Res 7 2 2010 95 112
159. M. Baumann Role of advanced glycation end products in hypertension and cardiovascular risk: human studies J Am Soc Hypertens 6 6 2012 427 435
160. K.H. Choi, J.W. Park, H.Y. Kim, Y.H. Kim, S.M. Kim, and Y.H. Son Cellular factors involved in CXCL8 expression induced by glycated serum albumin in vascular smooth muscle cells Atherosclerosis 209 1 2010 58 65
161. B.Y. Li, X.L. Li, Q. Cai, H.Q. Gao, M. Cheng, and J.H. Zhang Induction of lactadherin mediates the apoptosis of endothelial cells in response to advanced glycation end products and protective effects of grape seed procyanidin B2 and resveratrol Apoptosis 16 7 2011 732 745
162. Y.H. Jing, K.H. Chen, S.H. Yang, P.C. Kuo, and J.K. Chen Resveratrol ameliorates vasculopathy in STZ-induced diabetic rats: role of AGE-RAGE signalling Diabetes Metab Res Rev 26 3 2010 212 222
163. K. Mizutani, K. Ikeda, and Y. Yamori Resveratrol inhibits AGEs-induced proliferation and collagen synthesis activity in vascular smooth muscle cells from stroke-prone spontaneously hypertensive rats Biochem Biophys Res Commun 274 1 2000 61 67
164. K. Venkatachalam, S. Mummidi, D.M. Cortez, S.D. Prabhu, A.J. Valente, and B. Chandrasekar Resveratrol inhibits high glucose-induced PI3K/Akt/ERK-dependent interleukin-17 expression in primary mouse cardiac fibroblasts Am J Physiol Heart Circ Physiol 294 5 2008 H2078 H2087
165. C.J. Schwartz, A.J. Valente, E.A. Sprague, J.L. Kelley, and R.M. Nerem The pathogenesis of atherosclerosis: an overview Clin Cardiol 14 2 Suppl. 1 1991 I1 I16
166. S. Blankenberg, S. Barbaux, and L. Tiret Adhesion molecules and atherosclerosis Atherosclerosis 170 2 2003 191 203
167. J. Xiao, J. Song, V. Hodara, A. Ford, X.L. Wang, and Q. Shi Protective effects of resveratrol on TNF-alpha-induced endothelial cytotoxicity in baboon femoral arterial endothelial cells J Diabetes Res 2013 2013 185172
168. I. Cicha, K. Beronov, E.L. Ramirez, K. Osterode, M. Goppelt-Struebe, and D. Raaz Shear stress preconditioning modulates endothelial susceptibility to circulating TNF-alpha and monocytic cell recruitment in a simplified model of arterial bifurcations Atherosclerosis 207 1 2009 93 102
169. M.E. Ferrero, A.E. Bertelli, A. Fulgenzi, F. Pellegatta, M.M. Corsi, and M. Bonfrate Activity in vitro of resveratrol on granulocyte and monocyte adhesion to endothelium Am J Clin Nutr 68 6 1998 1208 1214
170. B.S. Wung, M.C. Hsu, C.C. Wu, and C.W. Hsieh Resveratrol suppresses IL-6-induced ICAM-1 gene expression in endothelial cells: effects on the inhibition of STAT3 phosphorylation Life Sci 78 4 2005 389 397
171. C. Rius, M. Abu-Taha, C. Hermenegildo, L. Piqueras, J.M. Cerda-Nicolas, and A.C. Issekutz Trans- but not cis-resveratrol impairs angiotensin-II-mediated vascular inflammation through inhibition of NF-kappaB activation and peroxisome proliferator-activated receptor-gamma upregulation J Immunol 185 6 2010 3718 3727
172. U.R. Pendurthi, and L.V. Rao Resveratrol suppresses agonist-induced monocyte adhesion to cultured human endothelial cells Thromb Res 106 4-5 2002 243 248
173. G. Villarreal Jr., Y. Zhang, H.B. Larman, J. Gracia-Sancho, A. Koo, and G. Garcia-Cardena Defining the regulation of KLF4 expression and its downstream transcriptional targets in vascular endothelial cells Biochem Biophys Res Commun 391 1 2010 984 989
174. J. Panee Monocyte chemoattractant protein 1 (MCP-1) in obesity and diabetes Cytokine 60 1 2012 1 12
175. D.W. Park, K. Baek, J.R. Kim, J.J. Lee, S.H. Ryu, and B.R. Chin Resveratrol inhibits foam cell formation via NADPH oxidase 1-mediated reactive oxygen species and monocyte chemotactic protein-1 Exp Mol Med 41 3 2009 171 179
176. J.P. Cullen, D. Morrow, Y. Jin, N. von Offenberg Sweeney, J.V. Sitzmann, and P.A. Cahill Resveratrol inhibits expression and binding activity of the monocyte chemotactic protein-1 receptor, CCR2, on THP-1 monocytes Atherosclerosis 195 1 2007 e125 e133
177. A.M. Gonzales, and R.A. Orlando Curcumin and resveratrol inhibit nuclear factor-kappaB-mediated cytokine expression in adipocytes Nutr Metab (Lond) 5 2008 17
178. I. Voloshyna, O. Hai, M.J. Littlefield, S. Carsons, and A.B. Reiss Resveratrol mediates anti-atherogenic effects on cholesterol flux in human macrophages and endothelium via PPARgamma and adenosine Eur J Pharmacol 698 1-3 2013 299 309
179. H. Berrougui, G. Grenier, S. Loued, G. Drouin, and A. Khalil A new insight into resveratrol as an atheroprotective compound: inhibition of lipid peroxidation and enhancement of cholesterol efflux Atherosclerosis 207 2 2009 420 427
180. M. Mietus-Snyder, M.S. Gowri, and R.E. Pitas Class A scavenger receptor up-regulation in smooth muscle cells by oxidized low density lipoprotein. Enhancement by calcium flux and concurrent cyclooxygenase-2 up-regulation J Biol Chem 275 23 2000 17661 17670
181. R.C. Braun-Dullaeus, M.J. Mann, and V.J. Dzau Cell cycle progression: new therapeutic target for vascular proliferative disease Circulation 98 1 1998 82 89
182. V.J. Hoglund, X.R. Dong, and M.W. Majesky Neointima formation: a local affair Arterioscler Thromb Vasc Biol 30 10 2010 1877 1879
183. A.M. El-Mowafy, and R.E. White Resveratrol inhibits MAPK activity and nuclear translocation in coronary artery smooth muscle: reversal of endothelin-1 stimulatory effects FEBS Lett 451 1 1999 63 67
184. A.M. El-Mowafy, M. Alkhalaf, and N.N. Nassar Resveratrol reverses ET-1-evoked mitogenic effects in human coronary arterial cells by activating the kinase-G to inhibit ERK-enzymes Int J Cardiol 136 3 2009 263 269
185. A.M. El-Mowafy, M. Alkhalaf, and H.A. El-Kashef Resveratrol reverses hydrogen peroxide-induced proliferative effects in human coronary smooth muscle cells: a novel signaling mechanism Arch Med Res 39 2 2008 155 161
186. H.H. Chao, S.H. Juan, J.C. Liu, H.Y. Yang, E. Yang, and T.H. Cheng Resveratrol inhibits angiotensin II-induced endothelin-1 gene expression and subsequent proliferation in rat aortic smooth muscle cells Eur J Pharmacol 515 1-3 2005 1 9
187. Y. Liu, and G. Liu Isorhapontigenin and resveratrol suppress oxLDL-induced proliferation and activation of ERK1/2 mitogen-activated protein kinases of bovine aortic smooth muscle cells Biochem Pharmacol 67 4 2004 777 785
188. L. Li, P. Gao, H. Zhang, H. Chen, W. Zheng, and X. Lv SIRT1 inhibits angiotensin II-induced vascular smooth muscle cell hypertrophy Acta Biochim Biophys Sin 43 2 2011 103 109
189. X. Zhang, Y. Wang, W. Yang, X. Hou, J. Zou, and K. Cao Resveratrol inhibits angiotensin II-induced ERK1/2 activation by downregulating quinone reductase 2 in rat vascular smooth muscle cells J Biomed Res 26 2 2012 103 109
190. U.G. Haider, T.U. Roos, M.I. Kontaridis, B.G. Neel, D. Sorescu, and K.K. Griendling Resveratrol inhibits angiotensin II- and epidermal growth factor-mediated Akt activation: role of Gab1 and Shp2 Mol Pharmacol 68 1 2005 41 48
191. P.M. Brito, R. Devillard, A. Negre-Salvayre, L.M. Almeida, T.C. Dinis, and R. Salvayre Resveratrol inhibits the mTOR mitogenic signaling evoked by oxidized LDL in smooth muscle cells Atherosclerosis 205 1 2009 126 134
192. J.L. Johnson, A. Dwivedi, M. Somerville, S.J. George, and A.C. Newby Matrix metalloproteinase (MMP)-3 activates MMP-9 mediated vascular smooth muscle cell migration and neointima formation in mice Arterioscler Thromb Vasc Biol 31 9 2011 e35 e44
193. B. Lee, and S.K. Moon Resveratrol inhibits TNF-alpha-induced proliferation and matrix metalloproteinase expression in human vascular smooth muscle cells J Nutr 135 12 2005 2767 2773
194. B. Venkatesan, A.J. Valente, V.S. Reddy, D.A. Siwik, and B. Chandrasekar Resveratrol blocks interleukin-18-EMMPRIN cross-regulation and smooth muscle cell migration Am J Physiol Heart Circ Physiol 297 2 2009 H874 H886
195. H. Ge, J.F. Zhang, B.S. Guo, Q. He, B.Y. Wang, and B. He Resveratrol inhibits macrophage expression of EMMPRIN by activating PPARgamma Vascul Pharmacol 46 2 2007 114 121
196. L. Wexler, B. Brundage, J. Crouse, R. Detrano, V. Fuster, and J. Maddahi Coronary artery calcification: pathophysiology, epidemiology, imaging methods, and clinical implications. A statement for health professionals from the American Heart Association. Writing Group Circulation 94 5 1996 1175 1192
197. C. Bruedigam, M. Eijken, M. Koedam, H. Chiba, and J.P. van Leeuwen Opposing actions of rosiglitazone and resveratrol on mineralization in human vascular smooth muscle cells J Mol Cell Cardiol 51 5 2011 862 871
198. A. Takemura, K. Iijima, H. Ota, B.K. Son, Y. Ito, and S. Ogawa Sirtuin 1 retards hyperphosphatemia-induced calcification of vascular smooth muscle cells Arterioscler Thromb Vasc Biol 31 9 2011 2054 2062
199. J. Steffel, T.F. Luscher, and F.C. Tanner Tissue factor in cardiovascular diseases: molecular mechanisms and clinical implications Circulation 113 5 2006 722 731
200. U.R. Pendurthi, J.T. Williams, and L.V. Rao Resveratrol, a polyphenolic compound found in wine, inhibits tissue factor expression in vascular cells: a possible mechanism for the cardiovascular benefits associated with moderate consumption of wine Arterioscler Thromb Vasc Biol 19 2 1999 419 426
201. A. Di Santo, A. Mezzetti, E. Napoleone, R. Di Tommaso, M.B. Donati, and G. De Gaetano Resveratrol and quercetin down-regulate tissue factor expression by human stimulated vascular cells J Thromb Haemost 1 5 2003 1089 1095
202. A. Breitenstein, S. Stein, E.W. Holy, G.G. Camici, C. Lohmann, and A. Akhmedov Sirt1 inhibition promotes in vivo arterial thrombosis and tissue factor expression in stimulated cells Cardiovasc Res 89 2 2011 464 472
203. J.C. Kovacic, P. Moreno, V. Hachinski, E.G. Nabel, and V. Fuster Cellular senescence, vascular disease, and aging: part 1 of a 2-part review Circulation 123 15 2011 1650 1660
204. J.C. Kovacic, P. Moreno, E.G. Nabel, V. Hachinski, and V. Fuster Cellular senescence, vascular disease, and aging: part 2 of a 2-part review: clinical vascular disease in the elderly Circulation 123 17 2011 1900 1910
205. L. Xia, X.X. Wang, X.S. Hu, X.G. Guo, Y.P. Shang, and H.J. Chen Resveratrol reduces endothelial progenitor cells senescence through augmentation of telomerase activity by Akt-dependent mechanisms Br J Pharmacol 155 3 2008 387 394
206. X.B. Wang, L. Zhu, J. Huang, Y.G. Yin, X.Q. Kong, and Q.F. Rong Resveratrol-induced augmentation of telomerase activity delays senescence of endothelial progenitor cells Chin Med J 124 24 2011 4310 4315
207. S. Yamashita, K. Ogawa, T. Ikei, M. Udono, T. Fujiki, and Y. Katakura SIRT1 prevents replicative senescence of normal human umbilical cord fibroblast through potentiating the transcription of human telomerase reverse transcriptase gene Biochem Biophys Res Commun 417 1 2012 630 634
208. B.S. Burlew, and K.T. Weber Cardiac fibrosis as a cause of diastolic dysfunction Herz 27 2 2002 92 98
209. E.R. Olson, J.E. Naugle, X. Zhang, J.A. Bomser, and J.G. Meszaros Inhibition of cardiac fibroblast proliferation and myofibroblast differentiation by resveratrol Am J Physiol Heart Circ Physiol 288 3 2005 H1131 H1138
210. S. Wang, X. Wang, J. Yan, X. Xie, F. Fan, and X. Zhou Resveratrol inhibits proliferation of cultured rat cardiac fibroblasts: correlated with NO-cGMP signaling pathway Eur J Pharmacol 567 1-2 2007 26 35
211. N. Frey, and E.N. Olson Cardiac hypertrophy: the good, the bad, and the ugly Annu Rev Physiol 65 2003 45 79
212. P. Wojciechowski, D. Juric, X.L. Louis, S.J. Thandapilly, L. Yu, and C. Taylor Resveratrol arrests and regresses the development of pressure overload - but not volume overload-induced cardiac hypertrophy in rats J Nutr 140 5 2010 962 968
213. S.J. Thandapilly, X.L. Louis, T. Yang, D.M. Stringer, L. Yu, and S. Zhang Resveratrol prevents norepinephrine induced hypertrophy in adult rat cardiomyocytes, by activating NO-AMPK pathway Eur J Pharmacol 668 1-2 2011 217 224
214. V.W. Dolinsky, A.Y. Chan, I. Robillard Frayne, P.E. Light, C. Des Rosiers, and J.R. Dyck Resveratrol prevents the prohypertrophic effects of oxidative stress on LKB1 Circulation 119 12 2009 1643 1652
215. V.W. Dolinsky, S. Chakrabarti, T.J. Pereira, T. Oka, J. Levasseur, and D. Beker Resveratrol prevents hypertension and cardiac hypertrophy in hypertensive rats and mice Biochim Biophys Acta 1832 10 2013 1723 1733
216. B.J. Wilkins, Y.S. Dai, O.F. Bueno, S.A. Parsons, J. Xu, and D.M. Plank Calcineurin/NFAT coupling participates in pathological, but not physiological, cardiac hypertrophy Circ Res 94 1 2004 110 118
217. A.Y. Chan, V.W. Dolinsky, C.L. Soltys, B. Viollet, S. Baksh, and P.E. Light Resveratrol inhibits cardiac hypertrophy via AMP-activated protein kinase and Akt J Biol Chem 283 35 2008 24194 24201
218. J. Backs, and E.N. Olson Control of cardiac growth by histone acetylation/deacetylation Circ Res 98 1 2006 15 24
219. A. Kuno, Y.S. Hori, R. Hosoda, M. Tanno, T. Miura, and K. Shimamoto Resveratrol improves cardiomyopathy in dystrophin-deficient mice through SIRT1 protein-mediated modulation of p300 protein J Biol Chem 288 8 2013 5963 5972
220. T.H. Cheng, J.C. Liu, H. Lin, N.L. Shih, Y.L. Chen, and M.T. Huang Inhibitory effect of resveratrol on angiotensin II-induced cardiomyocyte hypertrophy Naunyn-Schmiedeberg's Archiv Pharmacol 369 2 2004 239 244
221. A. Biala, E. Tauriainen, A. Siltanen, J. Shi, S. Merasto, and M. Louhelainen Resveratrol induces mitochondrial biogenesis and ameliorates Ang II-induced cardiac remodeling in transgenic rats harboring human renin and angiotensinogen genes Blood Press 19 3 2010 196 205
222. P.R. de Sauvage Nolting, J.C. Defesche, R.J. Buirma, B.A. Hutten, P.J. Lansberg, and J.J. Kastelein Prevalence and significance of cardiovascular risk factors in a large cohort of patients with familial hypercholesterolaemia J Intern Med 253 2 2003 161 168
223. G.S. Getz, and C.A. Reardon Paraoxonase, a cardioprotective enzyme: continuing issues Curr Opin Lipidol 15 3 2004 261 267
224. C. Gouedard, R. Barouki, and Y. Morel Induction of the paraoxonase-1 gene expression by resveratrol Arterioscler Thromb Vasc Biol 24 12 2004 2378 2383
225. F. Gilardi, N. Mitro, C. Godio, E. Scotti, D. Caruso, and M. Crestani The pharmacological exploitation of cholesterol 7alpha-hydroxylase, the key enzyme in bile acid synthesis: from binding resins to chromatin remodelling to reduce plasma cholesterol Pharmacol Ther 116 3 2007 449 472
226. Q. Chen, E. Wang, L. Ma, and P. Zhai Dietary resveratrol increases the expression of hepatic 7alpha-hydroxylase and ameliorates hypercholesterolemia in high-fat fed C57BL/6J mice Lipids Health Dis 11 2012 56
227. H.P. Monsour Jr., C.T. Frenette, and K. Wyne Fatty liver: a link to cardiovascular disease - its natural history, pathogenesis, and treatment Methodist Debakey Cardiovasc J 8 3 2012 21 25
228. G. Alberdi, V.M. Rodriguez, M.T. Macarulla, J. Miranda, I. Churruca, and M.P. Portillo Hepatic lipid metabolic pathways modified by resveratrol in rats fed an obesogenic diet Nutrition 29 3 2013 562 567
229. B.A. Gibson, and W.L. Kraus New insights into the molecular and cellular functions of poly(ADP-ribose) and PARPs Nat Rev Mol Cell Biol 13 7 2012 411 424
230. G.J. Southan, and C. Szabo Poly(ADP-ribose) polymerase inhibitors Curr Med Chem 10 4 2003 321 340
231. D. Beher, J. Wu, S. Cumine, K.W. Kim, S.C. Lu, and L. Atangan Resveratrol is not a direct activator of SIRT1 enzyme activity Chem Biol Drug Des 74 6 2009 619 624
232. M. Pacholec, J.E. Bleasdale, B. Chrunyk, D. Cunningham, D. Flynn, and R.S. Garofalo SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1 J Biol Chem 285 11 2010 8340 8351
233. R.A. Miller, D.E. Harrison, C.M. Astle, J.A. Baur, A.R. Boyd, and R. de Cabo Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice J Gerontol Ser A Biol Sci Med Sci 66 2 2011 191 201
234. A. Sahebkar Effects of resveratrol supplementation on plasma lipids: a systematic review and meta-analysis of randomized controlled trials Nutr Rev 71 12 2013 822 835
235. J. Marchal, F. Pifferi, and F. Aujard Resveratrol in mammals: effects on aging biomarkers, age-related diseases, and life span Ann NY Acad Sci 1290 2013 67 73
236. W. Chen, L. Rezaizadehnajafi, and M. Wink Influence of resveratrol on oxidative stress resistance and life span in Caenorhabditis elegans J Pharm Pharmacol 65 5 2013 682 688
237. V.A. Brown, K.R. Patel, M. Viskaduraki, J.A. Crowell, M. Perloff, and T.D. Booth Repeat dose study of the cancer chemopreventive agent resveratrol in healthy volunteers: safety, pharmacokinetics, and effect on the insulin-like growth factor axis Cancer Res 70 22 2010 9003 9011
238. J. Tome-Carneiro, M. Larrosa, M.J. Yanez-Gascon, A. Davalos, J. Gil-Zamorano, and M. Gonzalvez One-year supplementation with a grape extract containing resveratrol modulates inflammatory-related microRNAs and cytokines expression in peripheral blood mononuclear cells of type 2 diabetes and hypertensive patients with coronary artery disease Pharmacol Res 72 2013 69 82
239. T. Walle, F. Hsieh, M.H. DeLegge, J.E. Oatis Jr., and U.K. Walle High absorption but very low bioavailability of oral resveratrol in humans Drug Metab Dispos 32 12 2004 1377 1382
240. D.M. Goldberg, J. Yan, and G.J. Soleas Absorption of three wine-related polyphenols in three different matrices by healthy subjects Clin Biochem 36 1 2003 79 87
241. C.E. Storniolo, and J.J. Moreno Resveratrol metabolites have an antiproliferative effect on intestinal epithelial cancer cells Food Chem 134 3 2012 1385 1391
242. D.L. Lu, D.J. Ding, W.J. Yan, R.R. Li, F. Dai, and Q. Wang Influence of glucuronidation and reduction modifications of resveratrol on its biological activities Chembiochem 14 9 2013 1094 1104
243. S. Sharan, O.F. Iwuchukwu, D.J. Canney, C.L. Zimmerman, and S. Nagar In vivo-formed versus preformed metabolite kinetics of trans-resveratrol-3-sulfate and trans-resveratrol-3-glucuronide Drug Metab Dispos 40 10 2012 1993 2001
244. K.R. Patel, C. Andreadi, R.G. Britton, E. Horner-Glister, A. Karmokar, and S. Sale Sulfate metabolites provide an intracellular pool for resveratrol generation and induce autophagy with senescence Sci Transl Med 5 205 2013 205ra133
245. D. Delmas, V. Aires, D.J. Colin, E. Limagne, A. Scagliarini, and A.K. Cotte Importance of lipid microdomains, rafts, in absorption, delivery, and biological effects of resveratrol Ann NY Acad Sci 1290 2013 90 97
246. M.A. Augustin, L. Sanguansri, and T. Lockett Nano- and micro-encapsulated systems for enhancing the delivery of resveratrol Ann NY Acad Sci 1290 2013 107 112
247. C.K. Singh, J. George, and N. Ahmad Resveratrol-based combinatorial strategies for cancer management Ann NY Acad Sci 1290 2013 113 121
248. M.J. Amiot, B. Romier, T.M. Dao, R. Fanciullino, J. Ciccolini, and R. Burcelin Optimization of trans-Resveratrol bioavailability for human therapy Biochimie 95 6 2013 1233 1238
249. Y.Q. Xue, J.M. Di, Y. Luo, K.J. Cheng, X. Wei, and Z. Shi Resveratrol oligomers for the prevention and treatment of cancers Oxid Med Cell Longev 2014 2014 1 9 Article ID 765832
250. R. Pangeni, J.K. Sahni, J. Ali, S. Sharma, and S. Baboota Resveratrol: review on therapeutic potential and recent advances in drug delivery Expert Opin Drug Deliv 11 8 2014 1285 1298
251. L. Biasutto, and M. Zoratti Prodrugs of quercetin and resveratrol: a strategy under development Curr Drug Metab 15 1 2014 77 95
252. S. Wang, R. Su, S. Nie, M. Sun, J. Zhang, and D. Wu Application of nanotechnology in improving bioavailability and bioactivity of diet-derived phytochemicals J Nutr Biochem 25 4 2014 363 376
253. O.L. Blanchard, G. Friesenhahn, M.A. Javors, and J.M. Smoliga Development of a lozenge for oral transmucosal delivery of trans-resveratrol in humans: proof of concept PLoS ONE 9 2 2014 e90131
254. T. Ogas, T.P. Kondratyuk, and J.M. Pezzuto Resveratrol analogs: promising chemopreventive agents Ann NY Acad Sci 1290 2013 21 29
255. P. Jeandet, B. Delaunois, A. Aziz, D. Donnez, Y. Vasserot, and S. Cordelier Metabolic engineering of yeast and plants for the production of the biologically active hydroxystilbene, resveratrol J Biomed Biotechnol 2012 2012 1 14 Article ID 579089
256. D. Donnez, P. Jeandet, C. Clement, and E. Courot Bioproduction of resveratrol and stilbene derivatives by plant cells and microorganisms Trends Biotechnol 27 12 2009 706 713
257. K.R. Patel, E. Scott, V.A. Brown, A.J. Gescher, W.P. Steward, and K. Brown Clinical trials of resveratrol Ann N Y Acad Sci 1215 2011 161 169
258. R. Popat, T. Plesner, F. Davies, G. Cook, M. Cook, and P. Elliott A phase 2 study of SRT501 (resveratrol) with bortezomib for patients with relapsed and or refractory multiple myeloma Br J Haematol 160 5 2013 714 717
259. N.Y. Elmadhun, A.A. Sabe, M.P. Robich, L.M. Chu, A.D. Lassaletta, and F.W. Sellke The pig as a valuable model for testing the effect of resveratrol to prevent cardiovascular disease Ann N Y Acad Sci 1290 2013 130 135
260. B. Wright Forging a modern generation of polyphenol-based therapeutics Br J Pharmacol 169 4 2013 844 847
261. S. Kim, Y. Jin, Y. Choi, and T. Park Resveratrol exerts anti-obesity effects via mechanisms involving down-regulation of adipogenic and inflammatory processes in mice Biochem Pharmacol 81 11 2011 1343 1351
262. N.E. Kang, A.W. Ha, J.Y. Kim, and W.K. Kim Resveratrol inhibits the protein expression of transcription factors related adipocyte differentiation and the activity of matrix metalloproteinase in mouse fibroblast 3T3-L1 preadipocytes Nutr Res Pract 6 6 2012 499 504
263. T.Z. Shan, Y. Ren, T. Wu, C.X. Liu, and Y.Z. Wang Regulatory role of Sirt1 on the gene expression of fatty acid-binding protein 3 in cultured porcine adipocytes J Cell Biochem 107 5 2009 984 991
264. J. Ahn, I. Cho, S. Kim, D. Kwon, and T. Ha Dietary resveratrol alters lipid metabolism-related gene expression of mice on an atherogenic diet J Hepatol 49 6 2008 1019 1028
265. G. Alberdi, V.M. Rodriguez, J. Miranda, M.T. Macarulla, N. Arias, and C. Andres-Lacueva Changes in white adipose tissue metabolism induced by resveratrol in rats Nutr Metab (Lond) 8 1 2011 29
266. S.B. Pedersen, J. Olholm, S.K. Paulsen, M.F. Bennetzen, and B. Richelsen Low Sirt1 expression, which is upregulated by fasting, in human adipose tissue from obese women Int J Obes (Lond) 32 8 2008 1250 1255
267. N.L. Price, A.P. Gomes, A.J. Ling, F.V. Duarte, A. Martin-Montalvo, and B.J. North SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function Cell Metab 15 5 2012 675 690
268. A. Csiszar, N. Labinskyy, J.T. Pinto, P. Ballabh, H. Zhang, and G. Losonczy Resveratrol induces mitochondrial biogenesis in endothelial cells Am J Physiol Heart Circ Physiol 297 1 2009 H13 H20
269. B. Olas, and B. Wachowicz Resveratrol and vitamin C as antioxidants in blood platelets Thromb Res 106 2 2002 143 148
270. S.R. Bhatt, M.F. Lokhandwala, and A.A. Banday Resveratrol prevents endothelial nitric oxide synthase uncoupling and attenuates development of hypertension in spontaneously hypertensive rats Eur J Pharmacol 667 1-3 2011 258 264
271. H.F. Li, S.A. Chen, and S.N. Wu Evidence for the stimulatory effect of resveratrol on Ca(2+)-activated K+ current in vascular endothelial cells Cardiovasc Res 45 4 2000 1035 1045
272. L. Gojkovic-Bukarica, A. Novakovic, V. Kanjuh, M. Bumbasirevic, A. Lesic, and H. Heinle A role of ion channels in the endothelium-independent relaxation of rat mesenteric artery induced by resveratrol J Pharmacol Sci 108 1 2008 124 130
273. B. Coskun, S. Soylemez, A.I. Parlar, A. Tulga Ulus, S. Fehmi Katircioglu, and F. Akar Effect of resveratrol on nitrate tolerance in isolated human internal mammary artery J Cardiovasc Pharmacol 47 3 2006 437 445
274. Y. Tang, J. Xu, W. Qu, X. Peng, P. Xin, and X. Yang Resveratrol reduces vascular cell senescence through attenuation of oxidative stress by SIRT1/NADPH oxidase-dependent mechanisms J Nutr Biochem 23 11 2012 1410 1416
275. A. Csiszar, N. Labinskyy, A. Podlutsky, P.M. Kaminski, M.S. Wolin, and C. Zhang Vasoprotective effects of resveratrol and SIRT1: attenuation of cigarette smoke-induced oxidative stress and proinflammatory phenotypic alterations Am J Physiol Heart Circ Physiol 294 6 2008 H2721 H2735
276. H.C. Ou, F.P. Chou, H.M. Sheen, T.M. Lin, C.H. Yang, and W. Huey-Herng Sheu Resveratrol, a polyphenolic compound in red wine, protects against oxidized LDL-induced cytotoxicity in endothelial cells Clin Chim Acta 364 1-2 2006 196 204
277. Z. Ungvari, Z. Orosz, A. Rivera, N. Labinskyy, Z. Xiangmin, and S. Olson Resveratrol increases vascular oxidative stress resistance Am J Physiol Heart Circ Physiol 292 5 2007 H2417 H2424
278. H. Guo, Y. Chen, L. Liao, and W. Wu Resveratrol protects HUVECs from oxidized-LDL induced oxidative damage by autophagy upregulation via the AMPK/SIRT1 pathway Cardiovasc Drugs Ther 27 3 2013 189 198
279. Y. Li, Z. Cao, and H. Zhu Upregulation of endogenous antioxidants and phase 2 enzymes by the red wine polyphenol, resveratrol in cultured aortic smooth muscle cells leads to cytoprotection against oxidative and electrophilic stress Pharmacol Res 53 1 2006 6 15
280. C. Lu, I.F. Bambang, J.S. Armstrong, and M. Whiteman Resveratrol blocks high glucose-induced mitochondrial reactive oxygen species production in bovine aortic endothelial cells: role of phase 2 enzyme induction? Diabetes Obes Metab 10 4 2008 347 349
281. J.T. Hwang, D.Y. Kwon, O.J. Park, and M.S. Kim Resveratrol protects ROS-induced cell death by activating AMPK in H9c2 cardiac muscle cells Genes Nutr 2 4 2008 323 326
282. X.C. Lv, and H.Y. Zhou Resveratrol protects H9c2 embryonic rat heart derived cells from oxidative stress by inducing autophagy: role of p38 mitogen-activated protein kinase Can J Physiol Pharmacol 90 5 2012 655 662
283. A. Gutierrez-Perez, C. Cortes-Rojo, R. Noriega-Cisneros, E. Calderon-Cortes, S. Manzo-Avalos, and M. Clemente-Guerrero Protective effects of resveratrol on calcium-induced oxidative stress in rat heart mitochondria J Bioenerg Biomembr 43 2 2011 101 107
284. C.L. Kao, L.K. Chen, Y.L. Chang, M.C. Yung, C.C. Hsu, and Y.C. Chen Resveratrol protects human endothelium from H(2)O(2)-induced oxidative stress and senescence via SirT1 activation J Atheroscler Thromb 17 9 2010 970 979
285. J.J. Moreno Resveratrol modulates arachidonic acid release, prostaglandin synthesis, and 3T6 fibroblast growth J Pharmacol Exp Ther 294 1 2000 333 338
286. K. Subbaramaiah, W.J. Chung, P. Michaluart, N. Telang, T. Tanabe, and H. Inoue Resveratrol inhibits cyclooxygenase-2 transcription and activity in phorbol ester-treated human mammary epithelial cells J Biol Chem 273 34 1998 21875 21882
287. S.O. Moon, W. Kim, M.J. Sung, S. Lee, K.P. Kang, and D.H. Kim Resveratrol suppresses tumor necrosis factor-alpha-induced fractalkine expression in endothelial cells Mol Pharmacol 70 1 2006 112 119
288. Y.C. Oh, O.H. Kang, J.G. Choi, H.S. Chae, Y.S. Lee, and O.O. Brice Anti-inflammatory effect of resveratrol by inhibition of IL-8 production in LPS-induced THP-1 cells Am J Chin Med 37 6 2009 1203 1214
289. P.B. Jakus, N. Kalman, C. Antus, B. Radnai, Z. Tucsek, and F. Gallyas Jr. TRAF6 is functional in inhibition of TLR4-mediated NF-kappaB activation by resveratrol J Nutr Biochem 24 5 2013 819 823
290. F. Suenaga, K. Hatsushika, S. Takano, T. Ando, Y. Ohnuma, and H. Ogawa A possible link between resveratrol and TGF-beta: resveratrol induction of TGF-beta expression and signaling FEBS Lett 582 5 2008 586 590
291. P.D. Issuree, P.N. Pushparaj, S. Pervaiz, and A.J. Melendez Resveratrol attenuates C5a-induced inflammatory responses in vitro and in vivo by inhibiting phospholipase D and sphingosine kinase activities FASEB J 23 8 2009 2412 2424
292. Q.Q. Lin, C.F. Yan, R. Lin, J.Y. Zhang, W.R. Wang, and L.N. Yang SIRT1 regulates TNF-alpha-induced expression of CD40 in 3T3-L1 adipocytes via NF-kappaB pathway Cytokine 60 2 2012 447 455
293. X. Zhu, Q. Liu, M. Wang, M. Liang, X. Yang, and X. Xu Activation of Sirt1 by resveratrol inhibits TNF-alpha induced inflammation in fibroblasts PLoS ONE 6 11 2011 e27081
294. L. Yang, J. Zhang, C. Yan, J. Zhou, R. Lin, and Q. Lin SIRT1 regulates CD40 expression induced by TNF-alpha via NF-kB pathway in endothelial cells Cell Physiol Biochem 30 5 2012 1287 1298
295. J.Y. Deng, P.S. Hsieh, J.P. Huang, L.S. Lu, and L.M. Hung Activation of estrogen receptor is crucial for resveratrol-stimulating muscular glucose uptake via both insulin-dependent and -independent pathways Diabetes 57 7 2008 1814 1823
296. S.V. de Kreutzenberg, G. Ceolotto, I. Papparella, A. Bortoluzzi, A. Semplicini, and C. Dalla Man Downregulation of the longevity-associated protein sirtuin 1 in insulin resistance and metabolic syndrome: potential biochemical mechanisms Diabetes 59 4 2010 1006 1015
297. J. Zhang, L. Chen, J. Zheng, T. Zeng, H. Li, and H. Xiao The protective effect of resveratrol on islet insulin secretion and morphology in mice on a high-fat diet Diabetes Res Clin Pract 97 3 2012 474 482
298. D.M. Arrick, H. Sun, K.P. Patel, and W.G. Mayhan Chronic resveratrol treatment restores vascular responsiveness of cerebral arterioles in type 1 diabetic rats Am J Physiol Heart Circ Physiol 301 3 2011 H696 H703
299. M. Sulaiman, M.J. Matta, N.R. Sunderesan, M.P. Gupta, M. Periasamy, and M. Gupta Resveratrol, an activator of SIRT1, upregulates sarcoplasmic calcium ATPase and improves cardiac function in diabetic cardiomyopathy Am J Physiol Heart Circ Physiol 298 3 2010 H833 H843
300. J.M. Yun, A. Chien, I. Jialal, and S. Devaraj Resveratrol up-regulates SIRT1 and inhibits cellular oxidative stress in the diabetic milieu: mechanistic insights J Nutr Biochem 23 7 2012 699 705
301. M. Orimo, T. Minamino, H. Miyauchi, K. Tateno, S. Okada, and J. Moriya Protective role of SIRT1 in diabetic vascular dysfunction Arterioscler Thromb Vasc 29 6 2009 889 894
302. F. Delucchi, R. Berni, C. Frati, S. Cavalli, G. Graiani, and R. Sala Resveratrol treatment reduces cardiac progenitor cell dysfunction and prevents morpho-functional ventricular remodeling in type-1 diabetic rats PLoS ONE 7 6 2012 e39836
303. M. Minakawa, A. Kawano, Y. Miura, and K. Yagasaki Hypoglycemic effect of resveratrol in type 2 diabetic model db/db mice and its actions in cultured L6 myotubes and RIN-5F pancreatic beta-cells J Clin Biochem Nutr 48 3 2011 237 244
304. J.L. Bruder, T. Hsieh, K.M. Lerea, S.C. Olson, and J.M. Wu Induced cytoskeletal changes in bovine pulmonary artery endothelial cells by resveratrol and the accompanying modified responses to arterial shear stress BMC Cell Biol 2 2001 1
305. B.B. Cheng, Z.Q. Yan, Q.P. Yao, B.R. Shen, J.Y. Wang, and L.Z. Gao Association of SIRT1 expression with shear stress induced endothelial progenitor cell differentiation J Cell Biochem 113 12 2012 3663 3671
306. C. Auger, P.L. Teissedre, P. Gerain, N. Lequeux, A. Bornet, and S. Serisier Dietary wine phenolics catechin, quercetin, and resveratrol efficiently protect hypercholesterolemic hamsters against aortic fatty streak accumulation J Agric Food Chem 53 6 2005 2015 2021
307. M. Azorin-Ortuno, M.J. Yanez-Gascon, A. Gonzalez-Sarrias, M. Larrosa, F. Vallejo, and F.J. Pallares Effects of long-term consumption of low doses of resveratrol on diet-induced mild hypercholesterolemia in pigs: a transcriptomic approach to disease prevention J Nutr Biochem 23 7 2012 829 837
308. C. Tian, R. Zhang, X. Ye, C. Zhang, X. Jin, and Y. Yamori Resveratrol ameliorates high-glucose-induced hyperpermeability mediated by caveolae via VEGF/KDR pathway Genes Nutr 8 2 2013 231 239
309. J. Ahn, H. Lee, S. Kim, and T. Ha Resveratrol inhibits TNF-alpha-induced changes of adipokines in 3T3-L1 adipocytes Biochem Biophys Res Commun 364 4 2007 972 977
310. U.G. Haider, D. Sorescu, K.K. Griendling, A.M. Vollmar, and V.M. Dirsch Resveratrol increases serine15-phosphorylated but transcriptionally impaired p53 and induces a reversible DNA replication block in serum-activated vascular smooth muscle cells Mol Pharmacol 63 4 2003 925 932
311. B. Poussier, A.C. Cordova, J.P. Becquemin, and B.E. Sumpio Resveratrol inhibits vascular smooth muscle cell proliferation and induces apoptosis J Vasc Surg 42 6 2005 1190 1197
312. V.P. Ekshyyan, V.Y. Hebert, A. Khandelwal, and T.R. Dugas Resveratrol inhibits rat aortic vascular smooth muscle cell proliferation via estrogen receptor dependent nitric oxide production J Cardiovasc Pharmacol 50 1 2007 83 93
313. U.G. Haider, D. Sorescu, K.K. Griendling, A.M. Vollmar, and V.M. Dirsch Resveratrol suppresses angiotensin II-induced Akt/protein kinase B and p70 S6 kinase phosphorylation and subsequent hypertrophy in rat aortic smooth muscle cells Mol Pharmacol 62 4 2002 772 777
314. T. Ichiki, R. Miyazaki, A. Kamiharaguchi, T. Hashimoto, H. Matsuura, and S. Kitamoto Resveratrol attenuates angiotensin II-induced senescence of vascular smooth muscle cells Regul Pept 177 1-3 2012 35 39
315. M. Kumerz, E.H. Heiss, D. Schachner, A.G. Atanasov, and V.M. Dirsch Resveratrol inhibits migration and Rac1 activation in EGF- but not PDGF-activated vascular smooth muscle cells Mol Nutr Food Res 55 8 2011 1230 1236
316. J. Xia, X. Wu, Y. Yang, Y. Zhao, M. Fang, and W. Xie SIRT1 deacetylates RFX5 and antagonizes repression of collagen type I (COL1A2) transcription in smooth muscle cells Biochem Biophys Res Commun 428 2 2012 264 270
317. J.P. Huang, S.S. Huang, J.Y. Deng, C.C. Chang, Y.J. Day, and L.M. Hung Insulin and resveratrol act synergistically, preventing cardiac dysfunction in diabetes, but the advantage of resveratrol in diabetics with acute heart attack is antagonized by insulin Free Radic Biol Med 49 11 2010 1710 1721
318. M. Mokni, F. Limam, S. Elkahoui, M. Amri, and E. Aouani Strong cardioprotective effect of resveratrol, a red wine polyphenol, on isolated rat hearts after ischemia/reperfusion injury Arch Biochem Biophys 457 1 2007 1 6
319. M.P. Robich, R.M. Osipov, R. Nezafat, J. Feng, R.T. Clements, and C. Bianchi Resveratrol improves myocardial perfusion in a swine model of hypercholesterolemia and chronic myocardial ischemia Circulation 122 11 Suppl. 2010 S142 S149
320. H. Wang, H. Zhou, Y. Zou, Q. Liu, C. Guo, and G. Gao Resveratrol modulates angiogenesis through the GSK3beta/beta-catenin/TCF-dependent pathway in human endothelial cells Biochem Pharmacol 80 9 2010 1386 1395
321. M.P. Robich, L.M. Chu, T.A. Burgess, J. Feng, Y. Han, and R. Nezafat Resveratrol preserves myocardial function and perfusion in remote nonischemic myocardium in a swine model of metabolic syndrome J Am Coll Surg 215 5 2012 681 689
322. M. Shen, G.L. Jia, Y.M. Wang, and H. Ma Cardioprotective effect of resvaratrol pretreatment on myocardial ischemia-reperfusion induced injury in rats Vascul Pharmacol 45 2 2006 122 126
323. S. Wang, Y. Qian, D. Gong, Y. Zhang, and Y. Fan Resveratrol attenuates acute hypoxic injury in cardiomyocytes: correlation with inhibition of iNOS-NO signaling pathway Eur J Pharm Sci 44 3 2011 416 421
324. F. Uchiumi, T. Watanabe, S. Hasegawa, T. Hoshi, Y. Higami, and S. Tanuma The effect of resveratrol on the Werner syndrome RecQ helicase gene and telomerase activity Curr Aging Sci 4 1 2011 1 7
325. X. Han, S. Ling, W. Gan, L. Sun, J. Duan, and J.W. Xu 2,3,5,4′-Tetrahydroxystilbene-2-O-beta-d-glucoside ameliorates vascular senescence and improves blood flow involving a mechanism of p53 deacetylation Atherosclerosis 225 1 2012 76 82
326. M.Y. Kim, E.S. Kang, S.A. Ham, J.S. Hwang, T.S. Yoo, and H. Lee The PPARdelta-mediated inhibition of angiotensin II-induced premature senescence in human endothelial cells is SIRT1-dependent Biochem Pharmacol 84 12 2012 1627 1634
327. W. Wang, C. Yan, J. Zhang, R. Lin, Q. Lin, and L. Yang SIRT1 inhibits TNF-alpha-induced apoptosis of vascular adventitial fibroblasts partly through the deacetylation of FoxO1 Apoptosis 18 6 2013 689 701
328. Q. Li, and S.S. Hannah Wnt/beta-catenin signaling is downregulated but restored by nutrition interventions in the aged heart in mice Arch Gerontol Geriatr 55 3 2012 749 754
329. L.H. Abou-Agag, M.L. Aikens, E.M. Tabengwa, R.L. Benza, S.R. Shows, and H.E. Grenett Polyphyenolics increase t-PA and u-PA gene transcription in cultured human endothelial cells Alcohol Clin Exp Res 25 2 2001 155 162
330. T. Nihei, Y. Miura, and K. Yagasaki Inhibitory effect of resveratrol on proteinuria, hypoalbuminemia and hyperlipidemia in nephritic rats Life Sci 68 25 2001 2845 2852
331. S.H. Jin, J.H. Yang, B.Y. Shin, K. Seo, S.M. Shin, and I.J. Cho Resveratrol inhibits LXRalpha-dependent hepatic lipogenesis through novel antioxidant Sestrin2 gene induction Toxicol Appl Pharmacol 271 1 2013 95 105
332. C.W. Leong, C.H. Wong, S.C. Lao, E.C. Leong, I.F. Lao, and P.T. Law Effect of resveratrol on proliferation and differentiation of embryonic cardiomyoblasts Biochem Biophys Res Commun 360 1 2007 173 180