Forging a modern generation of polyphenol-based therapeutics

British Journal of Pharmacology

Volumn 169, Issue 4, 2013, Pages 844-847

  Wright, Bernice ^a  

^a UNIVERSITY OF READING   (United Kingdom)

Author keywords

biomaterial delivery systems; cardiovascular disease therapy; drug delivery; drug therapy; polyphenols; resveratrol; systems network pharmacology

Indexed keywords

ALGINIC ACID; B7 ANTIGEN; CASPASE 8; CD28 ANTIGEN; DEOXYCHOLATE SODIUM; GRAPE EXTRACT; HS 1793; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 10; PLANT EXTRACT; POLYCAPROLACTONE; POLYPHENOL; QUERCETIN 3 O AMINO ACID ESTER; RESVERATROL; SIRTUIN 1; STAPHYLOCOCCUS ENTEROTOXIN B; UNCLASSIFIED DRUG;

ANTIINFLAMMATORY ACTIVITY; ANTINEOPLASTIC ACTIVITY; ANTIOXIDANT ACTIVITY; APOPTOSIS; ATHEROSCLEROSIS; BREAST CANCER; CORONARY ARTERY DISEASE; DIET SUPPLEMENTATION; DRUG ABSORPTION; DRUG ACCUMULATION; DRUG BIOAVAILABILITY; DRUG CYTOTOXICITY; DRUG EFFECT; DRUG MECHANISM; DRUG POTENCY; DRUG SELECTIVITY; HUMAN; HYDROGEL; LUNG INJURY; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW; T LYMPHOCYTE ACTIVATION; THROMBOSIS;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ENTEROTOXINS; FEMALE; LUNG INJURY; PNEUMONIA; STILBENES;

EID: 84878303334     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/bph.12195     Document Type: Review

References (26)

1. Cadena PG, Pereira MA, Cordeiro RB, Cavalcanti IM, Barros Neto B, Pimentel Mdo C, et al. (2013). Nanoencapsulation of quercetin and resveratrol into elastic liposomes. Biochim Biophys Acta 1828: 309-316.
2. Chiva-Blanch G, Urpi-Sarda M, Lorach R, Rotches-Ribalta M, Guillen M, Casas R, et al. (2012). Differential effects of polyphenols and alcohol of red wine on the expression of adhesion molecules and inflammatory cytokines related to atherosclerosis: a randomized clinical trial. Am J Clin Nutr 95: 326-334.
3. Cottart CH, Nivet-Antoine V, Laguillier-Morizot C, Beaudeux JL, (2010). Resveratrol bioavailability and toxicity in humans. Mol Nutr Food Res 54: 7-16.
4. Dhandayuthapani S, Marimuthu P, Hormann VV, Kumi-Diaka J, Rathinavelu A, (2013). Induction of apoptosis in HeLa cells via caspase activation by resveratrol and genistein. J Med Food 16: 139-146.
5. Gali HU, Perchellet EM, Perchellet JP, (1991). Inhibition of tumor promoter-induced ornithine decarboxylase activity by tannic acid and other polyphenols in mouse epidermis in vivo. Cancer Res 51: 2820-2825.
6. Gatson JW, Liu MM, Abdelfattah K, Wigginton JG, Smith S, Wolf S, et al. (2013). Resveratrol decreases inflammation in the brain of mice with mild traumatic brain injury. J Trauma Acute Care Surg 74: 470-475.
7. Huang H, Jia Q, Ma J, Qin G, Chen Y, Xi Y, et al. (2009). Discovering novel quercetin-3-O-amino acid-esters as a new class of Src tyrosine kinase inhibitors. Eur J Med Chem 44: 1982-1989.
8. Iyengar R, Zhao S, Chung SW, Mager DE, Gallo JM, (2012). Merging systems biology with pharmacodynamics. Sci Transl Med 4: 126ps7.
9. Jacobson KA, Moro S, Manthey JA, West PL, Ji XD, (2002). Interactions of flavones and other phytochemicals with adenosine receptors. Adv Exp Med Biol 505: 163-171.
10. Kim HJ, Yang KM, Park YS, Choi YJ, Yun JH, Son CH, et al. (2012). The novel resveratrol analogue HS-1793 induces apoptosis via the mitochondrial pathway in murine breast cancer cells. Int J Oncol 41: 1628-1634.
11. Li Y, Danmark S, Edlund U, Finne-Wistrand A, He X, Norgard M, et al. (2011). Resveratrol-conjugated poly-ε-caprolactone facilitates in vitro mineralization and in vivo bone regeneration. Acta Biomater 7: 751-758.
12. Lin YL, Chang HC, Chen TL, Chang JH, Chiu WT, Lin JW, (2010). Resveratrol protects against oxidized LDL-induced breakage of the blood-brain barrier by lessening disruption of tight junctions and apoptotic insults to mouse cerebrovascular endothelial cells. J Nutr 140: 2187-2192.
13. Liu L, Gu L, Ma Q, Zhu D, Huang X, (2013). Resveratrol attenuates hydrogen peroxide-induced apoptosis in human umbilical vein endothelial cells. Eur Rev Med Pharmacol Sci 17: 88-94.
14. Manach C, Williamson G, Morand C, Scalbert A, Remesy C, (2005). Bioavailability and Bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies. Am J Clin Nutr 81: 230S-242S.
15. Mennen LI, Walker R, Bennetau-Pelissero C, Scalbert A, (2005). Risks and safety of polyphenol consumption. Am J Clin Nutr 81: 326S-329S.
16. Navarro-Nuñez L, Lozano ML, Palomo M, Martinez C, Vicente V, Castillo J, et al. (2008). Apigenin inhibits platelet adhesion and thrombus formation and synergises with aspirin in the suppression of the arachidonic acid pathway. J Agric Food Chem 56: 2970-2976.
17. Pawlikowska-Pawlega B, Gruszecki WI, Misiak L, Paduch R, Piersiak T, Zarzyka B, et al. (2007). Modification of membranes by quercetin, a naturally occurring flavonoid, via its incorporation in the polar head group. Biochim Biophys Acta 1768: 2195-2204.
18. Pignatelli P, Ghiselli A, Buchetti B, Carnevale R, Natella F, Germano G, et al. (2006). Polyphenols synergistically inhibit oxidative stress in subjects given red and white wine. Atherosclerosis 188: 77-83.
19. Quoc Trung L, Espinoza JL, Takami A, Nakao S, (2013). Resveratrol induces cell cycle arrest and apoptosis in malignant NK cells via JAK2/STAT3 pathway inhibition. PLoS ONE 8: e55183.
20. Rieder SA, Nagarkatti P, Nagarkatti M, (2012). Multiple anti-inflammatory pathways triggered by resveratrol lead to amelioration of staphylococcal enterotoxin B-induced lung injury. Br J Pharmacol 167: 1244-1258.
21. Scalbert A, (1993). Polyphenolic Phenomena. Institut National De La Recherche Agronomique: Paris.
22. Sharma S, Chopra K, Kulkarni SK, Agrewala JN, (2007). Resveratrol and curcumin suppress immune response through CD28/CTLA-4 and CD80 co-stimulatory pathway. Clin Exp Immunol 147: 155-163.
23. Tomé-Carneiro J, Gonzalvez M, Larrosa M, Yanez-Gascon MJ, Garcia-Almagro FJ, Ruiz-Ros JA, et al. (2013). Grape resveratrol increases serum adiponectin and down regulates inflammatory genes in peripheral blood mononuclear cells: a triple-blind, placebo-controlled, one-year clinical trial in patients with stable coronary artery disease. Cardiovasc Drugs Ther 27: 37-48.
24. Walle T, (2011). Bioavailability of resveratrol. Ann N Y Acad Sci 1215: 9-15.
25. Wright B, Moraes LA, Kemp CF, Mullen W, Crozier A, Lovegrove JA, et al. (2010). A structural basis for the inhibition of collagen-stimulated platelet function by quercetin and structurally related flavonoids. Br J Pharmacol 159: 1312-1325.
26. Wright B, Cave RA, Cook JP, Khutoryanskiy VV, Mi S, Chen B, et al. (2012). Structural modification of a calcium alginate gel for efficient transport/storage of corneal epithelial cells. Regen Med 7: 295-307.