Resveratrol prevents hyperglycemia-induced endothelial dysfunction via activation of adenosine monophosphate-activated protein kinase

Biochemical and Biophysical Research Communications

Volumn 388, Issue 2, 2009, Pages 389-394

  Xu, Qiang ^a   Hao, Xinzhong ^b   Yang, Qihong ^a   Si, Liangyi ^a  

^a THIRD MILITARY MEDICAL UNIVERSITY   (China)

^b General Hospital of PLA Chengdu Military Area Command   (China)

Author keywords

Adenosine monophosphate activated protein kinase; Endothelial dysfunction; Endothelial nitric oxide synthesis; Hyperglycemia; Nitric oxide; Reactive oxygen species; Resveratrol

Indexed keywords

CEFODIZIME; ENDOTHELIAL NITRIC OXIDE SYNTHASE; GLUCOSE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; MANNITOL; NITRIC OXIDE; RESVERATROL; SERINE; SUPEROXIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL CULTURE; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG MECHANISM; ENDOTHELIAL DYSFUNCTION; ENDOTHELIUM; ENDOTHELIUM CELL; ENZYME ACTIVITY; GLUCOSE INTAKE; HUMAN; HUMAN CELL; HYPERGLYCEMIA; LOW DRUG DOSE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; UMBILICAL VEIN; VASCULAR RING; VASODILATATION;

AMP-ACTIVATED PROTEIN KINASES; ANIMALS; ANTIOXIDANTS; CYTOPROTECTION; ENDOTHELIUM, VASCULAR; ENZYME ACTIVATION; HUMANS; HYPERGLYCEMIA; MALE; MICE; MICE, INBRED C57BL; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE III; PHOSPHORYLATION; STILBENES; SUPEROXIDES; VASODILATION;

EID: 69249216358     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2009.08.021     Document Type: Article

References (28)

1. Endemann D.H., and Schiffrin E.L. Endothelial dysfunction. J. Am. Soc. Nephrol. 15 (2004) 1983-1992
2. Calles-Escandon J., and Cipolla M. Diabetes and endothelial dysfunction: a clinical perspective. Endocr. Rev. 22 (2001) 36-52
3. Ouedraogo R., Wu X., Xu S.Q., Fuchsel L., Motoshima H., Mahadev K., Hough K., Scalia R., and Goldstein B.J. Adiponectin suppression of high-glucose-induced reactive oxygen species in vascular endothelial cells: evidence for involvement of a cAMP signaling pathway. Diabetes 55 (2006) 1840-1846
4. Barua R.S., Ambrose J.A., Srivastava S., DeVoe M.C., and Eales-Reynolds L.J. Reactive oxygen species are involved in smoking-induced dysfunction of nitric oxide biosynthesis and upregulation of endothelial nitric oxide synthase: an in vitro demonstration in human coronary artery endothelial cells. Circulation 107 (2003) 2342-2347
5. Hung L.M., Chen J.K., Huang S.S., Lee R.S., and Su M.J. Cardioprotective effect of resveratrol, a natural antioxidant derived from grapes. Cardiovasc. Res. 47 (2000) 549-555
6. Su H.C., Hung L.M., and Chen J.K. Resveratrol, a red wine antioxidant, possesses an insulin-like effect in streptozotocin-induced diabetic rats. Am. J. Physiol. Endocrinol. Metab. 290 (2006) E1339-E1346
7. Bradamante S., Barenghi L., and Villa A. Cardiovascular protective effects of resveratrol. Cardiovasc. Drug Rev. 22 (2004) 169-188
8. Breen D.M., Sanli T., Giacca A., and Tsiani E. Stimulation of muscle cell glucose uptake by resveratrol through sirtuins and AMPK. Biochem. Biophys. Res. Commun. 374 (2008) 117-122
9. Ceolotto G., Gallo A., Papparella I., Franco L., Murphy E., Iori E., Pagnin E., Fadini G.P., Albiero M., Semplicini A., and Avogaro A. Rosiglitazone reduces glucose-induced oxidative stress mediated by NAD(P)H oxidase via AMPK-dependent mechanism. Arterioscler. Thromb. Vasc. Biol. 27 (2007) 2627-2633
10. Zhang H., Zhang J., Ungvari Z., and Zhang C. Resveratrol improves endothelial function: role of TNF{alpha} and vascular oxidative stress. Arterioscler. Thromb. Vasc. Biol. 29 (2009) 1164-1171
11. Wallerath T., Deckert G., Ternes T., Anderson H., Li H., Witte K., and Forstermann U. Resveratrol, a polyphenolic phytoalexin present in red wine, enhances expression and activity of endothelial nitric oxide synthase. Circulation 106 (2002) 1652-1658
12. Fleming I., and Busse R. Signal transduction of eNOS activation. Cardiovasc. Res. 43 (1999) 532-541
13. Hartge M.M., Kintscher U., and Unger T. Endothelial dysfunction and its role in diabetic vascular disease. Endocrinol. Metab. Clin. North Am. 35 (2006) 551-560 viii-i
14. De Vriese A.S., Verbeuren T.J., Van de Voorde J., Lameire N.H., and Vanhoutte P.M. Endothelial dysfunction in diabetes. Br. J. Pharmacol. 130 (2000) 963-974
15. Mount P.F., Kemp B.E., and Power D.A. Regulation of endothelial and myocardial NO synthesis by multi-site eNOS phosphorylation. J. Mol. Cell. Cardiol. 42 (2007) 271-279
16. Hwang J.T., Kwon D.Y., Park O.J., and Kim M.S. Resveratrol protects ROS-induced cell death by activating AMPK in H9c2 cardiac muscle cells. Genes Nutr. 2 (2008) 323-326
17. Park C.E., Kim M.J., Lee J.H., Min B.I., Bae H., Choe W., Kim S.S., and Ha J. Resveratrol stimulates glucose transport in C2C12 myotubes by activating AMP-activated protein kinase. Exp. Mol. Med. 39 (2007) 222-229
18. Lage R., Dieguez C., Vidal-Puig A., and Lopez M. AMPK: a metabolic gauge regulating whole-body energy homeostasis. Trends Mol. Med. 14 (2008) 539-549
19. Claret M., Smith M.A., Batterham R.L., Selman C., Choudhury A.I., Fryer L.G., Clements M., Al-Qassab H., Heffron H., Xu A.W., Speakman J.R., Barsh G.S., Viollet B., Vaulont S., Ashford M.L., Carling D., and Withers D.J. AMPK is essential for energy homeostasis regulation and glucose sensing by POMC and AgRP neurons. J. Clin. Invest. 117 (2007) 2325-2336
20. Davis B.J., Xie Z., Viollet B., and Zou M.H. Activation of the AMP-activated kinase by antidiabetes drug metformin stimulates nitric oxide synthesis in vivo by promoting the association of heat shock protein 90 and endothelial nitric oxide synthase. Diabetes 55 (2006) 496-505
21. Schulz E., Schuhmacher S., and Munzel T. When metabolism rules perfusion: AMPK-mediated endothelial nitric oxide synthase activation. Circ. Res. 104 (2009) 422-424
22. Viollet B., Lantier L., Devin-Leclerc J., Hebrard S., Amouyal C., Mounier R., Foretz M., and Andreelli F. Targeting the AMPK pathway for the treatment of Type 2 diabetes. Front. Biosci. 14 (2009) 3380-3400
23. Zhang Y., Lee T.S., Kolb E.M., Sun K., Lu X., Sladek F.M., Kassab G.S., Garland Jr. T., and Shyy J.Y. AMP-activated protein kinase is involved in endothelial NO synthase activation in response to shear stress. Arterioscler. Thromb. Vasc. Biol. 26 (2006) 1281-1287
24. Whiteside C., Wang H., Xia L., Munk S., Goldberg H.J., and Fantus I.G. Rosiglitazone prevents high glucose-induced vascular endothelial growth factor and collagen IV expression in cultured mesangial cells. Exp. Diabetes Res. 2009 (2009) 910783
25. Kukidome D., Nishikawa T., Sonoda K., Imoto K., Fujisawa K., Yano M., Motoshima H., Taguchi T., Matsumura T., and Araki E. Activation of AMP-activated protein kinase reduces hyperglycemia-induced mitochondrial reactive oxygen species production and promotes mitochondrial biogenesis in human umbilical vein endothelial cells. Diabetes 55 (2006) 120-127
26. Beckman J.S., and Koppenol W.H. Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly. Am. J. Physiol. Cell. Physiol. 271 (1996) C1424-C1437
27. Salt I.P., Morrow V.A., Brandie F.M., Connell J.M., and Petrie J.R. High glucose inhibits insulin-stimulated nitric oxide production without reducing endothelial nitric-oxide synthase Ser1177 phosphorylation in human aortic endothelial cells. J. Biol. Chem. 278 (2003) 18791-18797
28. Cosentino F., Hishikawa K., Katusic Z.S., and Luscher T.F. High glucose increases nitric oxide synthase expression and superoxide anion generation in human aortic endothelial cells. Circulation 96 (1997) 25-28