Functional contribution of the endothelial component to the vasorelaxing effect of resveratrol and NS 1619, activators of the large-conductance calcium-activated potassium channels

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 375, Issue 1, 2007, Pages 73-80

  Calderone, Vincenzo ^a   Martelli, Alma ^a   Testai, Lara ^a   Martinotti, Enrica ^a   Breschi, Maria C ^a  

^a UNIVERSITY OF PISA   (Italy)

Author keywords

BK channels; Endothelium; Nitric oxide; NS 1619; Resveratrol

Indexed keywords

1 (2 HYDROXY 5 TRIFLUOROMETHYLPHENYL) 5 TRIFLUOROMETHYL 2(3H) BENZIMIDAZOLONE; 1H 1,2,4 OXADIAZOLO[4,3 A]QUINOXALIN 1 ONE; 4 AMINOPYRIDINE; IBERIOTOXIN; LARGE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; RESVERATROL; TETRYLAMMONIUM;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL TONE; CELL MEMBRANE DEPOLARIZATION; CONTROLLED STUDY; DRUG ACTIVITY; DRUG ANTAGONISM; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENCY; ENDOTHELIUM CELL; MALE; MEMBRANE CHANNEL; NONHUMAN; PHARMACODYNAMICS; RAT; VASCULAR RING; VASODILATATION;

4-AMINOPYRIDINE; ANIMALS; AORTA, THORACIC; BENZIMIDAZOLES; CALCIUM CHANNEL BLOCKERS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIUM, VASCULAR; ENZYME INHIBITORS; LARGE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS; MALE; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE; OXADIAZOLES; PEPTIDES; POTASSIUM CHLORIDE; QUINOXALINES; RATS; RATS, WISTAR; STILBENES; TETRAETHYLAMMONIUM; VASODILATION; VASODILATOR AGENTS;

EID: 33847619327     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00210-006-0129-3     Document Type: Article

References (54)

1. Amberg GC, Bonev AD, Rossow CF, Nelson MT, Santana LF (2003) Modulation of the molecular composition of large conductance, Ca(2+) activated K(+) channels in vascular smooth muscle during hypertension. J Clin Invest 112:717-724
2. Balwierczak JL, Krulan CM, Kim HS, DelGrande D, Weiss GB, Hu S (1995) Evidence that BKCa channel activation contributes to K+ channel opener induced relaxation of the porcine coronary artery. Naunyn Schmiedebergs Arch Pharmacol 352:213-221
3. Biagi G, Giorgi I, Livi O, Nardi A, Calderone V, Martelli A, Martinotti E, Salerni OL (2004) Synthesis and biological activity of novel substituted benzanilides as potassium channel activators. V Eur J Med Chem 39:491-498
4. Bolotina VM, Najibi S, Palacino JJ, Pagano PJ, Cohen RA (1994) Nitric oxide directly activates calcium-dependent potassium channels in vascular smooth muscle. Nature 28:850-853
5. Calderone V (2002) Large-conductance, Ca(2+)-activated k(+) channels: function, pharmacology and drugs. Curr Med Chem 9:1385-1395
6. Calderone V, Chericoni S, Martinelli C, Testai L, Nardi A, Morelli I, Breschi MC, Martinotti E (2004) Vasorelaxing effects of flavonoids: investigation on the possible involvement of potassium channels. Naunyn Schmiedebergs Arch Pharmacol 370:290-298
7. Calderone V, Giorgi I, Livi O, Martinotti E, Mantuano E, Martelli A, Nardi A (2005) Benzoyl and/or benzyl substituted 1,2,3-triazoles as potassium channel activators. VIII Eur J Med Chem 40:521-528
8. Coghlan MJ, Carroll WA, Gopalakrishnan M (2001) Recent developments in the biology and medicinal chemistry of potassium channel modulators: update from a decade of progress. J Med Chem 44:1627-1653
9. Cooke JP, Rossitch E Jr, Andon NA, Loscalzo J, Dzau VJ (1991) Flow activates an endothelial potassium channel to release an endogenous nitrovasodilator. J Clin Invest 88:1663-1671
10. +-channel gating energetics. J Gen Physiol 116:411-432
11. Da Silva-Santos JE, Assreuy J (1999) Long-lasting changes of rat blood pressure to vasoconstrictors and vasodilators induced by nitric oxide donor infusion: involvement of potassium channels. J Pharmacol Exp Ther 290:380-387
12. Dimitropoulou C, White RE, Fuchs L, Zhang H, Catravas JD, Carrier GO (2001) Angiotensin II relaxes microvessels via the AT(2) receptor and Ca(2+)-activated K(+) (BK(Ca)) channels. Hypertension 37:301-307
13. Faraci FM, Heistad DD (1998) Regulation of the cerebral circulation: role of endothelium and potassium channels. Physiol Rev 78:53-97
14. Feletou M, Vanhoutte PM (1999) The third pathway: endothelium-dependent hyperpolarization. J Physiol Pharmacol 50:525-534
15. Gribkoff VK, Starrett JE, Dworetzky SI (2001) Maxi-K potassium channels: form, function, and modulation of a class of endogenous regulators of intracellular calcium. Neuroscientist 7:166-177
16. Hille B (1992) Ionic channels of excitable membranes, 2nd edn. Sinauer Associates Inc: Sunderland, USA
17. Ca channel activator, NS 1619, on rat cerebral artery smooth muscle. Br J Pharmacol 117:119-129
18. Jackson WF (2000) Ion channels and vascular tone. Hypertension 35:173-178
19. Jacobs ER, Cheliakine C, Gebremedhin D, Birks EK, Davies PF, Harder DR (1995) Shear activated channels in cell-attached patches of cultured bovine aortic endothelial cells. Pflugers Arch 431:129-131
20. Kuhlmann CR, Trumper JR, Abdallah Y, Wiebke Ludders D, Schaefer CA, Most AK, Backenkohler U, Neumann T, Walther S, Piper HM, Tillmanns H, Erdogan A (2004) The K+-channel opener NS1619 increases endothelial NO-synthesis involving p42/p44 MAP-kinase. Thromb Haemost 92:1099-1107
21. Kume H, Mikawa K, Takagi K, Kotlikoff MI (1995) Role of G proteins and KCa channels in the muscarinic and beta-adrenergic regulation of airway smooth muscle. Am J Physiol 268:L221-L229
22. Kume H, Takai A, Tokuno H, Tomita T (1989) Regulation of Ca2+-dependent K+-channel activity in tracheal myocytes by phosphorylation. Nature 341:152-154
23. Kuriyama H, Kitamura K, Nabata H (1995) Pharmacological and physiological significance of ion channels and factors that modulate them in vascular tissues. Pharmacol Rev 47:387-573
24. Latorre R, Oberhauser A, Labarca P, Alvarez O (1989) Varieties of calcium-activated potassium channels. Annu Rev Physiol 51:385-399
25. Lawson K, McKay NG (2006) Modulation of potassium channels as a therapeutic approach. Curr Pharm Des 12:459-470
26. Li HF, Chen SA, Wu SN (2000) Evidence for the stimulatory effect of resveratrol on Ca(2+)-activated K+ current in vascular endothelial cells. Cardiovasc Res 45:1035-1045
27. Lu T, Katakam PV, VanRollins M, Weintraub NL, Spector AA, Lee HC (2001) Dihydroxyeicosatrienoic acids are potent activators of Ca(2+)-activated K(+) channels in isolated rat coronary arterial myocytes. J Physiol 534:651-667
28. + channel openers in bladder and vascular smooth muscle. Naunyn Schmiedebergs Arch Pharmacol 369:481-489
29. McManus OB (1991) Calcium-activated potassium channels: regulation by calcium. J Bioenerg Biomembr 23:537-560
30. Meera P, Wallner M, jiang Z, Toro L (1996) A calcium switch for maxi K channels. FEBS Lett 385:127-128
31. Michelakis ED, Reeve HL, Huang JM, Tolarova S, Nelson DP, Weir EK, Archer SL (1997) Potassium channel diversity in vascular smooth muscle cells. Can J Physiol Pharmacol 75:889-897
32. Nardi A, Calderone V, Chericoni S, Morelli I (2003) Natural modulators of large-conductance calcium-activated potassium channels. Planta Med 69:885-892
33. Nardi A, Calderone V, Olesen P-S (2006) Potassium channel openers: the case of BK channel activators. Lett Drug Des Discov 3:210-218
34. Nelson MT, Cheng H, Rubart M, Santana LF, Bonev AD, Knot HJ, Laderer WJ (1995) Relaxation of arterial smooth muscle by calcium sparks. Science 270:633-637
35. Papassotiriou J, Kohler R, Prenen J, Krause H, Akbar M, Eggermont J, Paul M, Distler A, Nilius B, Hoyer J (2000) Endothelial K(+) channel lacks the Ca(2+) sensitivity-regulating beta subunit. FASEB J 14:885-894
36. Perez G, Toro L (1994) Differential modulation of large-conductance KCa channels by PKA in pregnant and nonpregnant myometrium. Am J Physiol 266:C1459-C1463
37. Quayle JM, Nelson MT, Standen NB (1997) ATP-sensitive and inwardly rectifying potassium channels in smooth muscle. Physiol Rev 77:1165-1232
38. Reinhart PH, Chung S, Levitan IB (1989) A family of calcium-dependent potassium channels from rat brain. Neuron 2:1031-1041
39. Rusko J, Tanzi F, van Breemen C, Adams DJ (1992) Calcium-activated potassium channels in native endothelial cells from rabbit aorta: conductance, Ca2+ sensitivity and block. J Physiol 455:601-621
40. Sadoshima J, Akaike N, Kanaide H, Nakamura M (1988) Cyclic AMP modulates Ca-activated K channel in cultured smooth muscle cells of rat aortas. Am J Physiol 255:H754-H759
41. Sargent CA, Grover GJ, Antonaccio MJ, McCullough JR (1993) The cardioprotective, vasorelaxant and electrophysiological profile of the large conductance calcium-activated potassium channel opener NS-004. J Pharmacol Exp Ther 266:1422-1429
42. Scornik FS, Codina J, Birnbaumer L, Toro L (1993) Modulation of coronary smooth muscle KCa channels by Gs alpha independent of phosphorylation by protein kinase A. Am J Physiol 265:1460-1465
43. Shieh CC, Coghlan M, Sullivan JP, Gopalakrishnan M (2000) Potassium channels: molecular defects, diseases, and therapeutic opportunities. Pharmacol Rev 52:557-594
44. Sobey CG, Faraci FM (1999) Inhibitory effect of 4-aminopyridine on responses of the basilar artery to nitric oxide. Br J Pharmacol 126:1437-1443
45. Sobey CG, Heistad DD, Faraci FM (1998) Potassium channels mediate dilatation of cerebral arterioles in response to arachidonate. Am J Physiol 275:1606-1612
46. Sun D, Huang A, Koller A, Kaley G (2001) Endothelial K(ca) channels mediate flow-dependent dilation of arterioles of skeletal muscle and mesentery. Microvasc Res 61:179-186
47. Tanaka Y, Koike K, Toro L (2004) MaxiK channel roles in blood vessel relaxations induced by endothelium-derived relaxing factors and their molecular mechanisms. J Smooth Muscle Res 40:125-153
48. Taniguchi J, Furukawa KI, Shigekawa M (1993) Maxi K+ channels are stimulated by cyclic guanosine monophosphate-dependent protein kinase in canine coronary artery smooth muscle cells. Pflugers Arch 423:167-172
49. Vogalis F (2000) Potassium channels in gastrointestinal smooth muscle. J Auton Pharmacol 20:207-219
50. Williams DL Jr, Katz GM, Roy-Contancin L, Reuben JP (1988) Guanosine 5′-monophosphate modulates gating of high-conductance Ca2+-activated K+ channels in vascular smooth muscle cells. Proc Natl Acad Sci USA 85:9360-9364
51. Wu SN (2003) Large-conductance Ca2+-activated K+ channels:physiological role and pharmacology. Curr Med Chem 10:649-661
52. Wu SN, Wu AZ, Lin MW (2006) Pharmacological roles of the large-conductance calcium-activated potassium channel. Curr Top Med Chem 6:1025-1030
53. Yamaki F, Kaga M, Horinouchi T, Tanaka H, Koike K, Shigenobu K, Toro L, Tanaka Y (2001) MaxiK channel-mediated relaxation of guinea-pig aorta following stimulation of IP receptor with beraprost via cyclic AMP-dependent and -independent mechanisms. Naunyn Schmiedebergs Arch Pharmacol 364:538-550
54. Yamamura H, Ohi Y, Muraki K, Watanabe M, Imaizumi Y (2001) BK channel activation by NS-1619 is partially mediated by intracellular Ca2+ release in smooth muscle cells of porcine coronary artery. Br J Pharmacol 132:828-834