SIRT1 regulates CD40 expression induced by TNF-α via NF-κB pathway in endothelial cells

Cellular Physiology and Biochemistry

Volumn 30, Issue 5, 2012, Pages 1287-1298

  Yang, Lina ^a   Zhang, Jiye ^a   Yan, Chunfang ^b   Zhou, Jun ^a   Lin, Rong ^a   Lin, Qinqin ^a   Wang, Weirong ^a   Zhang, Kaifan ^a   Yang, Guangde ^a   Bian, Xiaoli ^a   Zeng, Aiguo ^a  

^a XI'AN JIAOTONG UNIVERSITY   (China)

^b Fourth Hospital of Xi'an City   (China)

Author keywords

Atherosclerosis; Cluster of differentiation 40; Endothelial cells; Infammation; Nuclear factor kappa B; SIRT1; Tumor necrosis factor

Indexed keywords

CD40 ANTIGEN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MESSENGER RNA; NICOTINAMIDE; RESVERATROL; SIRTINOL; SIRTUIN 1; SMALL INTERFERING RNA; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; CELLULAR DISTRIBUTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; REGULATORY MECHANISM; UMBILICAL VEIN ENDOTHELIAL CELL;

ANTIGENS, CD40; CELLS, CULTURED; ENDOTHELIAL CELLS; HUMANS; NF-KAPPA B; SIRTUIN 1; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84867440428     PISSN: 10158987     EISSN: 14219778     Source Type: Journal    
DOI: 10.1159/000343318     Document Type: Article

References (51)

1. Michan S, Sinclair D: Sirtuins in mammals: Insights into their biological function. Biochem J 2007;404:1-13. (Pubitemid 46788079)
2. Dvir-Ginzberg M, Gagarina V, Lee EJ, Booth R, Gabay O, Hall DJ: Tumor necrosis factor alpha-mediated cleavage and inactivation of sirt1 in human osteoarthritic chondrocytes. Arthritis Rheum 2011;63:2363-2373.
3. Kitada M, Takeda A, Nagai T, Ito H, Kanasaki K, Koya D: Dietary restriction ameliorates diabetic nephropathy through anti-inflammatory effects and regulation of the autophagy via restoration of sirt1 in diabetic wistar fatty (fa/fa) rats: A model of type 2 diabetes. Exp Diabetes Res 2011;2011:908185.
4. Rajendrasozhan S, Yang S-R, Kinnula VL, Rahman I: Sirt1, an antiinflammatory and antiaging protein, is decreased in lungs of patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2008;177:861-870. (Pubitemid 351600664)
5. Yoshizaki T, Milne JC, Imamura T, Schenk S, Sonoda N, Babendure JL, Lu JC, Smith JJ, Jirousek MR, Olefsky JM: Sirt1 exerts anti-inflammatory effects and improves insulin sensitivity in adipocytes. Mol Cell Biol 2009;29:1363-1374.
6. Gracia-Sancho J, Villarreal G Jr, Zhang Y, Garcia-Cardena G: Activation of sirt1 by resveratrol induces klf2 expression conferring an endothelial vasoprotective phenotype. Cardiovasc Res 2010;85:514-519.
7. Stein S, Lohmann C, Schaefer N, Hofmann J, Rohrer L, Besler C, Rothgiesser KM, Becher B, Hottiger MO, Boren J, McBurney MW, Landmesser U, Luescher TF, Matter CM: Sirt1 decreases lox-1-mediated foam cell formation in atherogenesis. Eur Heart J 2010;31:2301-2309.
8. Zhang QJ, Wang Z, Chen HZ, Zhou S, Zheng W, Liu G, Wei YS, Cai H, Liu DP, Liang CC: Endothelium-specific overexpression of class III deacetylase sirt1 decreases atherosclerosis in apolipoprotein e-deficient mice. Cardiovasc Res 2008;80:191-199.
9. Ross R: Mechanisms of disease - atherosclerosis - an inflammatory disease. N Engl J Med 1999;340:115-126.
10. Lutgens E, Daemen M: CD40-cd40l interactions in atherosclerosis. Trends Cardiovasc Med 2002;12:27-32. (Pubitemid 34055720)
11. Engel D, Seijkens T, Poggi M, Sanati M, Thevissen L, Beckers L, Wijnands E, Lievens D, Lutgens E: The immunobiology of CD154-cd40-traf interactions in atherosclerosis. Semin Immunol 2009;21:308-312.
12. Garlichs CD, Cicha I, Raaz D, Meyer L, Stumpf C, Klinghammer L, Yilmaz A, Daniel WG: CD40/CD154 system and pro-inflammatory cytokines in young healthy male smokers without additional risk factors for atherosclerosis. Inflamm Res 2009;58:306-311.
13. Lutgens E, Lievens D, Beckers L, Donners M, Daemen M: CD40 and its ligand in atherosclerosis. Trends Cardiovasc Med 2007;17:118-123. (Pubitemid 46670021)
14. Tousoulis D, Androulakis E, Papageorgiou N, Briasoulis A, Siasos G, Antoniades C, Stefanadis C: From atherosclerosis to acute coronary syndromes: The role of soluble CD40 ligand. Trends Cardiovasc Med 2010;20:153-164.
15. Fang ZY, Lin R, Yuan BX, Yang GD, Liu Y, Zhang H: Tanshinone IIa downregulates the CD40 expression and decreases mmp-2 activity on atherosclerosis induced by high fatty diet in rabbit. J Ethnopharmacol 2008;115:217-222. (Pubitemid 350266262)
16. Lin R, Wang WR, Liu JT, Yang GD, Han CJ: Protective effect of tanshinone IIa on human umbilical vein endothelial cell injured by hydrogen peroxide and its mechanism. J Ethnopharmacol 2006;108:217-222. (Pubitemid 44635028)
17. Salminen A, Kauppinen A, Suuronen T, Kaarniranta K: Sirt1 longevity factor suppresses NF-kappa b-driven immune responses: Regulation of aging via NF-kappa b acetylation? Bioessays 2008;30:939-942.
18. Lin R, Liu JT, Peng N, Yang GD, Gan WJ, Wang WR: Lovastatin reduces nuclear factor kappa b activation induced by c-reactive protein in human vascular endothelial cells. Biol Pharm Bull 2005;28:1630-1634. (Pubitemid 41324122)
19. Tone M, Tone Y, Babik JM, Lin CY, Waldmann H: The role of sp1 and NF-kappa b in regulating CD40 gene expression. J Biol Chem 2002;277:8890-8897. (Pubitemid 34952958)
20. Krzesz R, Wagner AH, Cattaruzza M, Hecker M: Cytokine-inducible CD40 gene expression in vascular smooth muscle cells is mediated by nuclear factor kappa b and signal transducer and activate of transcription-1. FEBS Lett 1999;453:191-196. (Pubitemid 29335498)
21. Chung S, Yao H, Caito S, Hwang JW, Arunachalam G, Rahman I: Regulation of sirt1 in cellular functions: Role of polyphenols. Arch Biochem Biophys 2010;501:79-90.
22. Ji Y, Liu J, Wang Z, Liu N: Angiotensin II induces inflammatory response partly via toll-like receptor 4-dependent signaling pathway in vascular smooth muscle cells. Cell Physiol Biochem 2009;23:265-276.
23. Shen Z, Ajmo JM, Rogers CQ, Liang X, Le L, Murr MM, Peng Y, You M: Role of sirt1 in regulation of lps-or two ethanol metabolites-induced tnf-alpha production in cultured macrophage cell lines. Am J Physiol-Gastroint Liver Physiol 2009;296:G1047-G1053.
24. Arunachalam G, Yao H, Sundar IK, Caito S, Rahman I: Sirt1 regulates oxidant-and cigarette smoke-induced enos acetylation in endothelial cells: Role of resveratrol. Biochem Biophys Res Commun 2010;393:66-72.
25. Cardellini M, Menghini R, Martelli E, Casagrande V, Marino A, Rizza S, Porzio O, Mauriello A, Solini A, Ippoliti A, Lauro R, Folli F, Federici M: Timp3 is reduced in atherosclerotic plaques from subjects with type 2 diabetes and increased by sirt1. Diabetes 2009;58:2396-2401.
26. Kao CL, Chen LK, Chang YL, Yung MC, Hsu CC, Chen YC, Lo WL, Chen SJ, Ku HH, Hwang S-J: Resveratrol protects human endothelium from H2O2-induced oxidative stress and senescence via sirt1 activation. J Atheroscler Thromb 2010;17:970-979.
27. Lin R, Liu JT, Gan WJ, Yang GD: C-reactive protein-induced expression of CD40-CD40l and the effect of lovastatin and fenotibrate on it in human vascular endothelial cells. Biol Pharm Bull 2004;27:1537-1543. (Pubitemid 41701635)
28. Lin R, Liu JT, Peng N, Gan WJ, Wang WR, Han CJ, Ding CJ: Lovastatin reduces apoptosis and downregulates the CD40 expression induced by TNF-alpha in cerebral vascular endothelial cells. Curr Neurovasc Res 2006;3:41-47.
29. Shen F, Chen SJ, Dong XJ, Zhong H, Li YT, Cheng GF: Suppression of il-8 gene transcription by resveratrol in phorbol ester treated human monocytic cells. J Asian Nat Prod Res 2003;5:151-157. (Pubitemid 36566099)
30. Yang J, Wang N, Li J, Zhang J, Feng P: Effects of resveratrol on no secretion stimulated by insulin and its dependence on sirt1 in high glucose cultured endothelial cells. Endocrine 2010;37:365-372.
31. Zhu X, Liu Q, Wang M, Liang M, Yang X, Xu X, Zou H, Qiu J: Activation of sirt1 by resveratrol inhibits tnf-alpha induced inflammation in fibroblasts. PLoS One 2011;6.
32. Csiszar A, Labinskyy N, Jimenez R, Pinto JT, Ballabh P, Losonczy G, Pearson KJ, De Cabo R, Ungvari Z: Antioxidative and anti-inflammatory vasoprotective effects of caloric restriction in aging: Role of circulating factors and sirt1. Mech Ageing Dev 2009;130:518-527.
33. Purushotham A, Schug TT, Xu Q, Surapureddi S, Guo X, Li X: Hepatocyte-specific deletion of sirt1 alters fatty acid metabolism and results in hepatic steatosis and inflammation. Cell Metab 2009;9:327-338.
34. Li X, Zhang S, Blander G, Tse JG, Krieger M, Guarente L: Sirt1 deacetylates and positively regulates the nuclear receptor lxr. Mol Cell 2007;28:91-106. (Pubitemid 47531974)
35. Mattagajasingh I, Kim CS, Naqvi A, Yamamori T, Hoffman TA, Jung SB, De Ricco J, Kasuno K, Irani K: Sirt1 promotes endothelium-dependent vascular relaxation by activating endothelial nitric oxide synthase. Proc Natl Acad Sci USA 2007;104:14855-14860. (Pubitemid 350003232)
36. Ota H, Akishita M, Eto M, Iijima K, Kaneki M, Ouchi Y: Sirt1 modulates premature senescence-like phenotype in human endothelial cells. J Mol Cell Cardiol 2007;43:571-579. (Pubitemid 47615048)
37. Yu W, Fu YC, Chen CJ, Wang X, Wang W: Sirt1: A novel target to prevent atherosclerosis. J Cell Biochem 2009;108:10-13.
38. Li L, Gao P, Zhang H, Chen H, Zheng W, Lv X, Xu T, Wei Y, Liu D, Liang C: Sirt1 inhibits angiotensin II-induced vascular smooth muscle cell hypertrophy. Acta Biochim Biophys Sin 2011;43:103-109.
39. Breitenstein A, Stein S, Holy EW, Camici GG, Lohmann C, Akhmedov A, Spescha R, Elliott PJ, Westphal CH, Matter CM, Luescher TF, Tanner FC: Sirt1 inhibition promotes in vivo arterial thrombosis and tissue factor expression in stimulated cells. Cardiovasc Res 2011;89:464-472.
40. Brunet A, Sweeney LB, Sturgill JF, Chua KF, Greer PL, Lin YX, Tran H, Ross SE, Mostoslavsky R, Cohen HY, Hu LS, Cheng HL, Jedrychowski MP, Gygi SP, Sinclair DA, Alt FW, Greenberg ME: Stress-dependent regulation of foxo transcription factors by the sirt1 deacetylase. Science 2004;303:2011-2015. (Pubitemid 38393275)
41. Lagouge M, Argmann C, Gerhart-Hines Z, Meziane H, Lerin C, Daussin F, Messadeq N, Milne J, Lambert P, Elliott P, Geny B, Laakso M, Puigserver P, Auwerx J: Resveratrol improves mitochondrial function and protects against metabolic disease by activating sirt1 and pgc-1 alpha. Cell 2006;127:1109-1122. (Pubitemid 44894520)
42. Luo JY, Nikolaev AY, Imai S, Chen DL, Su F, Shiloh A, Guarente L, Gu W: Negative control of p53 by sir2 alpha promotes cell survival under stress. Cell 2001;107:137-148. (Pubitemid 33035941)
43. Motta MC, Divecha N, Lemieux M, Kamel C, Chen D, Gu W, Bultsma Y, McBurney M, Guarente L: Mammalian sirt1 represses forkhead transcription factors. Cell 2004;116:551-563. (Pubitemid 38264432)
44. Yeung F, Hoberg JE, Ramsey CS, Keller MD, Jones DR, Frye RA, Mayo MW: Modulation of nf-kappa b-dependent transcription and cell survival by the sirt1 deacetylase. EMBO J 2004;23:2369-2380. (Pubitemid 38954844)
45. Chen LF, Mu YJ, Greene WC: Acetylation of reia at discrete sites regulates distinct nuclear functions of NF-kappa b. EMBO J 2002;21:6539-6548. (Pubitemid 35448431)
46. Chen LF, Williams SA, Mu YJ, Nakano H, Duerr JM, Buckbinder L, Greene WC: NF-kappa b rela phosphorylation regulates rela acetylation. Mol Cell Biol 2005;25:7966-7975. (Pubitemid 41262991)
47. Chen J, Zhou YG, Mueller-Steiner S, Chen LF, Kwon H, Yi SL, Mucke L, Li G: Sirt1 protects against microgliadependent amyloid-beta toxicity through inhibiting NF-kappa b signaling. J Biol Chem 2005;280:40364-40374. (Pubitemid 41779174)
48. Csiszar A, Smith K, Labinskyy N, Orosz Z, Rivera A, Ungvari Z: Resveratrol attenuates TNF-alpha-induced activation of coronary arterial endothelial cells: Role of NF-kb inhibition. Am J Physiol-Heart Circul Physiol 2006;291:H1694-H1699. (Pubitemid 44497674)
49. Zhu J, Yong W, Wu X, Yu Y, Lv J, Liu C, Mao X, Zhu Y, Xu K, Han X, Liu C: Anti-inflammatory effect of resveratrol on tnf-alpha-induced mcp-1 expression in adipocytes. Biochem Biophys Res Commun 2008;369:471-477.
50. Schug TT, Xu Q, Gao H, Peres-da-Silva A, Draper DW, Fessler MB, Purushotham A, Li X: Myeloid deletion of sirt1 induces inflammatory signaling in response to environmental stress. Mol Cell Biol 2010;30:4712-4721.
51. Yang SR, Wright J, Bauter M, Seweryniak K, Kode A, Rahman I: Sirtuin regulates cigarette smoke-induced proinflammatory mediator release via rela/p65 NF-kappa b in macrophages in vitro and in rat lungs in vivo: Implications for chronic inflammation and aging. Am J Physiol-Lung Cell Mol Physiol 2007;292:L567-L576.