Sulfate metabolites provide an intracellular pool for resveratrol generation and induce autophagy with senescence

Science Translational Medicine

Volumn 5, Issue 205, 2013, Pages

  Patel, Ketan R ^a   Andreadi, Catherine ^a   Britton, Robert G ^a   Horner Glister, Emma ^a   Karmokar, Ankur ^a   Sale, Stewart ^a   Brown, Victoria A ^a   Brenner, Dean E ^b   Singh, Rajinder ^a   Steward, William P ^a   Gescher, Andreas J ^a   Brown, Karen ^a  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARRIER PROTEIN; PHENOL DERIVATIVE; RESVERATROL; RESVERATROL 3 O SULFATE; RESVERATROL 4' O SULFATE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; AREA UNDER THE CURVE; ARTICLE; AUTOPHAGY; CELL TRANSPORT; CONTROLLED STUDY; DOSE RESPONSE; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG ELIMINATION; DRUG HALF LIFE; DRUG METABOLISM; HUMAN; HUMAN CELL; HUMAN TISSUE; HYDROLYSIS; IN VIVO STUDY; MAXIMUM PLASMA CONCENTRATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REPEATED DRUG DOSE; SENESCENCE; SINGLE DRUG DOSE;

ANIMALS; AUTOPHAGY; CELL AGING; CELL LINE, TUMOR; CELL PROLIFERATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COLORECTAL NEOPLASMS; GLUCURONIDES; HUMANS; INTRACELLULAR SPACE; MEMBRANE TRANSPORT PROTEINS; MICE; MICE, INBRED C57BL; STILBENES; SULFATES;

EID: 84885454938     PISSN: 19466234     EISSN: 19466242     Source Type: Journal    
DOI: 10.1126/scitranslmed.3005870     Document Type: Article

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