Cyclic nucleotide-dependent relaxation pathways in vascular smooth muscle

Cellular and Molecular Life Sciences

Volumn 69, Issue 2, 2012, Pages 247-266

  Morgado, Manuel ^a   Cairrão, Elisa ^a   Santos Silva, António José ^a   Verde, Ignacio ^a  

^a UNIVERSITY OF BEIRA INTERIOR   (Portugal)

Author keywords

Calcium sensitivity; Cyclic AMP; Cyclic GMP; Myosin light chain; PKA; PKG; Vascular smooth muscle; Vasorelaxation

Indexed keywords

ADENOSINE TRIPHOSPHATASE (CALCIUM); ADENOSINE TRIPHOSPHATE SENSITIVE POTASSIUM CHANNEL; CALCIUM; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC GMP; CYCLIC GMP DEPENDENT PROTEIN KINASE; CYCLIC NUCLEOTIDE; INWARDLY RECTIFYING POTASSIUM CHANNEL; LARGE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL; MYOSIN LIGHT CHAIN; MYOSIN LIGHT CHAIN KINASE; MYOSIN LIGHT CHAIN PHOSPHATASE; SODIUM CALCIUM EXCHANGE PROTEIN; VOLTAGE GATED POTASSIUM CHANNEL;

CALCIUM CELL LEVEL; CALCIUM MOBILIZATION; CALCIUM TRANSPORT; CELL COMPARTMENTALIZATION; ENZYME ACTIVITY; HUMAN; HYPERPOLARIZATION; MUSCLE RELAXATION; NONHUMAN; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; REVIEW; SIGNAL TRANSDUCTION; SMOOTH MUSCLE CONTRACTION; SMOOTH MUSCLE FIBER MEMBRANE POTENTIAL; SMOOTH MUSCLE TONE; VASCULAR SMOOTH MUSCLE;

ANIMALS; CALCIUM; CALCIUM-TRANSPORTING ATPASES; HUMANS; MICE; MUSCLE CONTRACTION; MUSCLE, SMOOTH, VASCULAR; MYOSIN-LIGHT-CHAIN KINASE; MYOSIN-LIGHT-CHAIN PHOSPHATASE; NUCLEOTIDES, CYCLIC; POTASSIUM CHANNELS; RATS; SARCOPLASMIC RETICULUM; SODIUM-CALCIUM EXCHANGER; VASODILATION; VASODILATOR AGENTS;

EID: 84856224116     PISSN: 1420682X     EISSN: 14209071     Source Type: Journal    
DOI: 10.1007/s00018-011-0815-2     Document Type: Review

References (220)

1. DA Woodrum CM Brophy 2001 The paradox of smooth muscle physiology Mol Cell Endocrinol 177 1-2 135 143 11377829 1:CAS:528:DC%2BD3MXjslSktb8%3D (Pubitemid 32506814)
2. K Hirano M Hirano H Kanaide 2004 Regulation of myosin phosphorylation and myofilament Ca2+ sensitivity in vascular smooth muscle J Smooth Muscle Res 40 6 219 236 15725705 (Pubitemid 40372154)
3. E Ihara JA MacDonald 2007 The regulation of smooth muscle contractility by zipper-interacting protein kinase Can J Physiol Pharmacol 85 1 79 87 17487247 1:CAS:528:DC%2BD2sXltFCntLw%3D (Pubitemid 46996106)
4. CM Rembold 1992 Regulation of contraction and relaxation in arterial smooth muscle Hypertension 20 2 129 137 1639454 1:CAS:528:DyaK38XlsVOltrc%3D
5. AP Somlyo AV Somlyo 1998 From pharmacomechanical coupling to G-proteins and myosin phosphatase Acta Physiol Scand 164 4 437 448 9887967 1:CAS:528:DyaK1MXltFCitA%3D%3D (Pubitemid 29015663)
6. F Orallo 1996 Regulation of cytosolic calcium levels in vascular smooth muscle Pharmacol Ther 69 153 171 8783369 1:CAS:528:DyaK28Xjt1CrtbY%3D (Pubitemid 26175236)
7. J Marin A Encabo A Briones EC Garcia-Cohen MJ Alonso 1999 Mechanisms involved in the cellular calcium homeostasis in vascular smooth muscle: calcium pumps Life Sci 64 5 279 303 10072189 1:CAS:528:DyaK1MXksVeisw%3D%3D (Pubitemid 29051518)
8. K Hirano DN Derkach M Hirano J Nishimura H Kanaide 2003 Protein kinase network in the regulation of phosphorylation and dephosphorylation of smooth muscle myosin light chain Mol Cell Biochem 248 1-2 105 114 12870661 1:CAS:528:DC%2BD3sXksFWnsLs%3D (Pubitemid 36833647)
9. T Akata 2007 Cellular and molecular mechanisms regulating vascular tone. Part 1: basic mechanisms controlling cytosolic Ca2+ concentration and the Ca2+-dependent regulation of vascular tone J Anesth 21 2 220 231 17458652 (Pubitemid 46692015)
10. KA Dora 2010 Coordination of vasomotor responses by the endothelium Circ J 74 2 226 232 20065608 1:CAS:528:DC%2BC3cXitlamtLY%3D
11. C de Wit TM Griffith 2010 Connexins and gap junctions in the EDHF phenomenon and conducted vasomotor responses Pflugers Arch 459 6 897 914 20379740
12. TM Griffith AT Chaytor HJ Taylor BD Giddings DH Edwards 2002 cAMP facilitates EDHF-type relaxations in conduit arteries by enhancing electrotonic conduction via gap junctions Proc Natl Acad Sci USA 99 9 6392 6397 11972050 1:CAS:528:DC%2BD38Xjslaitbc%3D (Pubitemid 34493322)
13. AT Chaytor HJ Taylor TM Griffith 2002 Gap junction-dependent and -independent EDHF-type relaxations may involve smooth muscle cAMP accumulation Am J Physiol Heart Circ Physiol 282 4 H1548 H1555 11893592 1:CAS:528: DC%2BD38XivVenuro%3D
14. J Hanoune N Defer 2001 Regulation and role of adenylyl cyclase isoforms Annu Rev Pharmacol Toxicol 41 145 174 11264454 1:CAS:528:DC%2BD3MXjsVaqsbY%3D (Pubitemid 32385886)
15. D Willoughby DM Cooper 2007 Organization and Ca2+ regulation of adenylyl cyclases in cAMP microdomains Physiol Rev 87 3 965 1010 17615394 1:CAS:528:DC%2BD2sXptFGlsL8%3D (Pubitemid 47084674)
16. LR Potter S Abbey-Hosch DM Dickey 2006 Natriuretic peptides, their receptors, and cyclic guanosine monophosphate-dependent signaling functions Endocr Rev 27 1 47 72 16291870 1:CAS:528:DC%2BD28XitFSit7c%3D (Pubitemid 43228238)
17. SP Cary JA Winger ER Derbyshire MA Marletta 2006 Nitric oxide signaling: no longer simply on or off Trends Biochem Sci 31 4 231 239 16530415 1:CAS:528:DC%2BD28Xjs1GltL4%3D
18. T Morita MA Perrella ME Lee S Kourembanas 1995 Smooth muscle cell-derived carbon monoxide is a regulator of vascular cGMP Proc Natl Acad Sci USA 92 5 1475 1479 7878003 1:CAS:528:DyaK2MXktFWktLc%3D
19. M Ushiyama T Morita S Katayama 2002 Carbon monoxide regulates blood pressure cooperatively with nitric oxide in hypertensive rats Heart Vessels 16 5 189 195 12181592
20. Peers C, Steele DS (2011) Carbon monoxide: a vital signalling molecule and potent toxin in the myocardium. J Mol Cell Cardiol (in press)
21. AH Polizio DM Santa-Cruz KB Balestrasse MM Gironacci FM Bertera C Hocht CA Taira ML Tomaro SB Gorzalczany 2011 Heme oxygenase-1 overexpression fails to attenuate hypertension when the nitric oxide synthase system is not fully operative Pharmacology 87 5-6 341 349 21646819 1:CAS:528:DC%2BC3MXnvF2rt70%3D
22. JS Isenberg Y Qin JB Maxhimer JM Sipes D Despres J Schnermann WA Frazier DD Roberts 2009 Thrombospondin-1 and CD47 regulate blood pressure and cardiac responses to vasoactive stress Matrix Biol 28 2 110 119 19284971 1:CAS:528:DC%2BD1MXjvVWjur0%3D
23. M Yao DD Roberts JS Isenberg 2011 Thrombospondin-1 inhibition of vascular smooth muscle cell responses occurs via modulation of both cAMP and cGMP Pharmacol Res 63 1 13 22 20971192 1:CAS:528:DC%2BC3MXps1SntA%3D%3D
24. JS Isenberg F Hyodo K Matsumoto MJ Romeo M Abu-Asab M Tsokos P Kuppusamy DA Wink MC Krishna DD Roberts 2007 Thrombospondin-1 limits ischemic tissue survival by inhibiting nitric oxide-mediated vascular smooth muscle relaxation Blood 109 5 1945 1952 17082319 1:CAS:528:DC%2BD2sXjtFeqtLk%3D (Pubitemid 46348191)
25. R Moudgil ED Michelakis SL Archer 2005 Hypoxic pulmonary vasoconstriction J Appl Physiol 98 1 390 403 15591309 1:CAS:528:DC%2BD2MXotFGnsw%3D%3D (Pubitemid 40041273)
26. T Burke-Wolin CJ Abate MS Wolin GH Gurtner 1991 Hydrogen peroxide-induced pulmonary vasodilation-role of guanosine 3', 5'-cyclic monophosphate Am J Physiol 261 L393 L398 1662918 1:CAS:528:DyaK38Xht1aku7o%3D
27. JR Burgoyne M Madhani F Cuello RL Charles JP Brennan E Schroder DD Browning P Eaton 2007 Cysteine redox sensor in PKGIa enables oxidant-induced activation Science 317 5843 1393 1397 17717153 1:CAS:528:DC%2BD2sXpvFWmu7s%3D (Pubitemid 47417480)
28. BH Neo S Kandhi MS Wolin 2010 Roles for soluble guanylate cyclase and a thiol oxidation-elicited subunit dimerization of protein kinase G in pulmonary artery relaxation to hydrogen peroxide Am J Physiol Heart Circ Physiol 299 4 H1235 H1241 20709865 1:CAS:528:DC%2BC3cXhtlKltbfM
29. MB Hussain RJ MacAllister AJ Hobbs 2001 Reciprocal regulation of cGMP-mediated vasorelaxation by soluble and particulate guanylate cyclases Am J Physiol Heart Circ Physiol 280 3 H1151 H1159 11179059 1:CAS:528: DC%2BD3MXjtV2gur4%3D
30. M Madhani RS Scotland RJ MacAllister AJ Hobbs 2003 Vascular natriuretic peptide receptor-linked particulate guanylate cyclases are modulated by nitric oxide-cyclic GMP signalling Br J Pharmacol 139 7 1289 1296 12890708 1:CAS:528:DC%2BD3sXmvVCisrs%3D (Pubitemid 37026412)
31. M Madhani M Okorie AJ Hobbs RJ MacAllister 2006 Reciprocal regulation of human soluble and particulate guanylate cyclases in vivo Br J Pharmacol 149 6 797 801 17016498 1:CAS:528:DC%2BD28XhtF2jsbrL (Pubitemid 44748072)
32. E Cairrao AJ Santos-Silva I Verde 2010 PKG is involved in testosterone-induced vasorelaxation of human umbilical artery Eur J Pharmacol 640 94 101 20444426 1:CAS:528:DC%2BC3cXnvVOgsrw%3D
33. C Lugnier 2006 Cyclic nucleotide phosphodiesterase (PDE) superfamily: a new target for the development of specific therapeutic agents Pharmacol Ther 109 3 366 398 16102838 1:CAS:528:DC%2BD28XnslylsA%3D%3D (Pubitemid 43132818)
34. K Omori J Kotera 2007 Overview of PDEs and their regulation Circ Res 100 3 309 327 17307970 1:CAS:528:DC%2BD2sXhsF2kurY%3D
35. JS Oakhill R Steel ZP Chen JW Scott N Ling S Tam BE Kemp 2011 AMPK is a direct adenylate charge-regulated protein kinase Science 332 6036 1433 1435 21680840 1:CAS:528:DC%2BC3MXntlOltL0%3D
36. SC Stein A Woods NA Jones MD Davison D Carling 2000 The regulation of AMP-activated protein kinase by phosphorylation Biochem J 345 Pt 3 437 443 10642499 1:CAS:528:DC%2BD3cXisFOlsLk%3D (Pubitemid 30099070)
37. A Woods D Vertommen D Neumann R Turk J Bayliss U Schlattner T Wallimann D Carling MH Rider 2003 Identification of phosphorylation sites in AMP-activated protein kinase (AMPK) for upstream AMPK kinases and study of their roles by site-directed mutagenesis J Biol Chem 278 31 28434 28442 12764152 1:CAS:528:DC%2BD3sXlsl2nt70%3D (Pubitemid 36935745)
38. DS Hutchinson RJ Summers T Bengtsson 2008 Regulation of AMP-activated protein kinase activity by G-protein coupled receptors: potential utility in treatment of diabetes and heart disease Pharmacol Ther 119 3 291 310 18606183 1:CAS:528:DC%2BD1cXhtVyltbjE
39. F Hofmann R Feil T Kleppisch J Schlossmann 2006 Function of cGMP-dependent protein kinases as revealed by gene deletion Physiol Rev 86 1 1 23 16371594 1:CAS:528:DC%2BD28XhtlKnsbk%3D
40. JA Smith RB Reed SH Francis K Grimes JD Corbin 2000 Distinguishing the roles of the two different cGMP-binding sites for modulating phosphorylation of exogenous substrate (heterophosphorylation) and autophosphorylation of cGMP-dependent protein kinase J Biol Chem 275 1 154 158 10617599 1:CAS:528:DC%2BD3cXjvVGktQ%3D%3D (Pubitemid 30038966)
41. R Fischmeister LR Castro A Abi-Gerges F Rochais J Jurevicius J Leroy G Vandecasteele 2006 Compartmentation of cyclic nucleotide signaling in the heart: the role of cyclic nucleotide phosphodiesterases Circ Res 99 8 816 828 17038651 1:CAS:528:DC%2BD28XhtVKjtL%2FP (Pubitemid 44556380)
42. TM Lincoln TL Cornwell AE Taylor 1990 cGMP-dependent protein kinase mediates the reduction of Ca2+ by cAMP in vascular smooth muscle cells Am J Physiol 258 (3 Pt 1) C399 C407 2156436 1:CAS:528:DyaK3cXhvFGqt7k%3D
43. M Arejian Y Li MB Anand-Srivastava 2009 Nitric oxide attenuates the expression of natriuretic peptide receptor C and associated adenylyl cyclase signaling in aortic vascular smooth muscle cells: role of MAPK Am J Physiol Heart Circ Physiol 296 6 H1859 H1867 19252090 1:CAS:528:DC%2BD1MXnsF2lt7o%3D
44. BS Skalhegg Y Huang T Su RL Idzerda GS McKnight KA Burton 2002 Mutation of the Calpha subunit of PKA leads to growth retardation and sperm dysfunction Mol Endocrinol 16 3 630 639 11875122 1:CAS:528:DC%2BD38XitFSisb8%3D (Pubitemid 34214581)
45. A Pfeifer P Klatt S Massberg L Ny M Sausbier C Hirneiss GX Wang M Korth A Aszodi KE Andersson F Krombach A Mayerhofer P Ruth R Fassler F Hofmann 1998 Defective smooth muscle regulation in cGMP kinase I-deficient mice EMBO J 17 11 3045 3051 9606187 1:CAS:528:DyaK1cXjvFeju7Y%3D (Pubitemid 28254377)
46. S Weber D Bernhard R Lukowski P Weinmeister R Worner JW Wegener N Valtcheva S Feil J Schlossmann F Hofmann R Feil 2007 Rescue of cGMP kinase I knockout mice by smooth muscle specific expression of either isozyme Circ Res 101 11 1096 1103 17901360 1:CAS:528:DC%2BD2sXhtlahurvF (Pubitemid 350146435)
47. R Feil N Gappa M Rutz J Schlossmann CR Rose A Konnerth S Brummer S Kuhbandner F Hofmann 2002 Functional reconstitution of vascular smooth muscle cells with cGMP-dependent protein kinase I isoforms Circ Res 90 10 1080 1086 12039797 1:CAS:528:DC%2BD38XktlSnsbw%3D (Pubitemid 34627906)
48. M Gloerich JL Bos 2010 Epac: defining a new mechanism for cAMP action Annu Rev Pharmacol Toxicol 50 355 375 20055708 1:CAS:528:DC%2BC3cXisVelurY%3D
49. SS Roscioni CR Elzinga M Schmidt 2008 Epac: effectors and biological functions Naunyn Schmiedebergs Arch Pharmacol 377 4-6 345 357 18176800 1:CAS:528:DC%2BD1cXnsVSqtrY%3D
50. M Metrich M Berthouze E Morel B Crozatier AM Gomez F Lezoualc'h 2010 Role of the cAMP-binding protein Epac in cardiovascular physiology and pathophysiology Pflugers Arch 459 4 535 546 19855995 1:CAS:528: DC%2BC3cXitlKitLg%3D
51. H Karaki H Ozaki M Hori M Mitsui-Saito K Amano K Harada S Miyamoto H Nakazawa KJ Won K Sato 1997 Calcium movements, distribution, and functions in smooth muscle Pharmacol Rev 49 2 157 230 9228665 1:CAS:528:DyaK2sXkslCrurs%3D (Pubitemid 27291033)
52. TM Lincoln N Dey H Sellak 2001 Invited review: cGMP-dependent protein kinase signaling mechanisms in smooth muscle: from the regulation of tone to gene expression J Appl Physiol 91 3 1421 1430 11509544 1:CAS:528: DC%2BD3MXmvV2qtL8%3D (Pubitemid 32803941)
53. T Akata 2007 Cellular and molecular mechanisms regulating vascular tone. Part 2: regulatory mechanisms modulating Ca2+ mobilization and/or myofilament Ca2+ sensitivity in vascular smooth muscle cells J Anesth 21 2 232 242 17458653 (Pubitemid 46692016)
54. A Cogolludo L Moreno E Villamor 2007 Mechanisms controlling vascular tone in pulmonary arterial hypertension: implications for vasodilator therapy Pharmacology 79 2 65 75 17148943 1:CAS:528:DC%2BD2sXjslOks7Y%3D (Pubitemid 46555217)
55. G Martel P Hamet J Tremblay 2010 Central role of guanylyl cyclase in natriuretic peptide signaling in hypertension and metabolic syndrome Mol Cell Biochem 334 1-2 53 65 19937369 1:CAS:528:DC%2BC3cXkt1Gqug%3D%3D
56. AB Vaandrager HR de Jonge 1996 Signalling by cGMP-dependent protein kinases Mol Cell Biochem 157 1-2 23 30 8739225 1:CAS:528:DyaK28Xjt1arsLY%3D (Pubitemid 26142433)
57. Y Tanaka G Tang K Takizawa K Otsuka M Eghbali M Song K Nishimaru K Shigenobu K Koike E Stefani L Toro 2006 Kv channels contribute to nitric oxide- and atrial natriuretic peptide-induced relaxation of a rat conduit artery J Pharmacol Exp Ther 317 1 341 354 16394199 1:CAS:528:DC%2BD28XjsVWmtbg%3D
58. RA Cohen RM Weisbrod M Gericke M Yaghoubi C Bierl VM Bolotina 1999 Mechanism of nitric oxide-induced vasodilatation: refilling of intracellular stores by sarcoplasmic reticulum Ca2+ ATPase and inhibition of store-operated Ca2+ influx Circ Res 84 2 210 219 9933253 1:CAS:528:DyaK1MXpsVGmsA%3D%3D (Pubitemid 29070117)
59. VM Bolotina S Najibi JJ Palacino PJ Pagano RA Cohen 1994 Nitric oxide directly activates calcium-dependent potassium channels in vascular smooth muscle Nature 368 6474 850 853 7512692 1:CAS:528:DyaK2cXjtF2qtL4%3D (Pubitemid 24137748)
60. BE Robertson R Schubert J Hescheler MT Nelson 1993 cGMP-dependent protein kinase activates Ca-activated K channels in cerebral artery smooth muscle cells Am J Physiol 265 1 Pt 1 C299 C303 8338137 1:CAS:528:DyaK3sXmt1anu74%3D
61. H Dong GJ Waldron WC Cole CR Triggle 1998 Roles of calcium-activated and voltage-gated delayed rectifier potassium channels in endothelium-dependent vasorelaxation of the rabbit middle cerebral artery Br J Pharmacol 123 5 821 832 9535009 1:CAS:528:DyaK1cXhs1ymsL4%3D (Pubitemid 28085381)
62. SD Rybalkin C Yan KE Bornfeldt JA Beavo 2003 Cyclic GMP phosphodiesterases and regulation of smooth muscle function Circ Res 93 4 280 291 12933699 1:CAS:528:DC%2BD3sXmt1OhsrY%3D (Pubitemid 37048240)
63. RS Ostrom X Liu BP Head C Gregorian TM Seasholtz PA Insel 2002 Localization of adenylyl cyclase isoforms and G protein-coupled receptors in vascular smooth muscle cells: expression in caveolin-rich and noncaveolin domains Mol Pharmacol 62 5 983 992 12391260 1:CAS:528:DC%2BD38XosVKjurw%3D (Pubitemid 35222489)
64. P Komalavilas TM Lincoln 1994 Phosphorylation of the inositol 1, 4, 5-trisphosphate receptor by cyclic GMP-dependent protein kinase J Biol Chem 269 12 8701 8707 8132598 1:CAS:528:DyaK2cXis1Kktr8%3D (Pubitemid 24209175)
65. P Komalavilas TM Lincoln 1996 Phosphorylation of the inositol 1, 4, 5-trisphosphate receptor-cyclic GMP-dependent protein kinase mediates cAMP and cGMP dependent phosphorylation in the intact rat aorta J Biol Chem 271 21933 21938 8702997 1:CAS:528:DyaK28XlsFKgu7Y%3D (Pubitemid 26303817)
66. J Schlossmann A Ammendola K Ashman X Zong A Huber G Neubauer GX Wang HD Allescher M Korth M Wilm F Hofmann P Ruth 2000 Regulation of intracellular calcium by a signalling complex of IRAG, IP3 receptor and cGMP kinase Ibeta Nature 404 6774 197 201 10724174 1:CAS:528:DC%2BD3cXhvFOit7c%3D (Pubitemid 30154489)
67. DE Casteel GR Boss RB Pilz 2005 Identification of the interface between cGMP-dependent protein kinase Ibeta and its interaction partners TFII-I and IRAG reveals a common interaction motif J Biol Chem 280 46 38211 38218 16166082 1:CAS:528:DC%2BD2MXht1SktL7L (Pubitemid 43853716)
68. A Geiselhoringer M Werner K Sigl P Smital R Worner L Acheo J Stieber P Weinmeister R Feil S Feil J Wegener F Hofmann J Schlossmann 2004 IRAG is essential for relaxation of receptor-triggered smooth muscle contraction by cGMP kinase EMBO J 23 21 4222 4231 15483626 (Pubitemid 39546160)
69. RM Fritsch D Saur M Kurjak D Oesterle J Schlossmann A Geiselhoringer F Hofmann HD Allescher 2004 InsP3R-associated cGMP kinase substrate (IRAG) is essential for nitric oxide-induced inhibition of calcium signaling in human colonic smooth muscle J Biol Chem 279 13 12551 12559 14729908 1:CAS:528:DC%2BD2cXitl2gsbg%3D (Pubitemid 38445826)
70. A Geiselhoringer M Gaisa F Hofmann J Schlossmann 2004 Distribution of IRAG and cGKI-isoforms in murine tissues FEBS Lett 575 1-3 19 22 15388327 1:CAS:528:DC%2BD2cXnvV2ksb8%3D (Pubitemid 39237675)
71. DE Casteel T Zhang S Zhuang RB Pilz 2008 cGMP-dependent protein kinase anchoring by IRAG regulates its nuclear translocation and transcriptional activity Cell Signal 20 7 1392 1399 18450420 1:CAS:528:DC%2BD1cXlvF2ksL0%3D
72. M Desch K Sigl B Hieke K Salb F Kees D Bernhard A Jochim B Spiessberger K Hocherl R Feil S Feil R Lukowski JW Wegener F Hofmann J Schlossmann 2011 IRAG determines nitric oxide- and atrial natriuretic peptide-mediated smooth muscle relaxation Cardiovasc Res 86 3 496 505
73. RM Rapoport 1986 Cyclic guanosine monophosphate inhibition of contraction may be mediated through inhibition of phosphatidylinositol hydrolysis in rat aorta Circ Res 58 3 407 410 3013461 1:CAS:528:DyaL28XhsVaksrs%3D (Pubitemid 16120766)
74. M Hirata KP Kohse CH Chang T Ikebe F Murad 1990 Mechanism of cyclic GMP inhibition of inositol phosphate formation in rat aorta segments and cultured bovine aortic smooth muscle cells J Biol Chem 265 3 1268 1273 2153123 1:CAS:528:DyaK3cXpt1WhsQ%3D%3D
75. TL Cornwell KB Pryzwansky TA Wyatt TM Lincoln 1991 Regulation of sarcoplasmic reticulum protein phosphorylation by localized cyclic GMP-dependent protein kinase in vascular smooth muscle cells Mol Pharmacol 40 6 923 931 1836834 1:CAS:528:DyaK38XlsVOku7o%3D
76. TM Lincoln TL Cornwell 1991 Towards an understanding of the mechanism of action of cyclic AMP and cyclic GMP in smooth muscle relaxation Blood Vessels 28 1-3 129 137 1848122 1:CAS:528:DyaK3MXlsFSntL0%3D
77. C Mundina-Weilenmann L Vittone G Rinaldi M Said GC de Cingolani A Mattiazzi 2000 Endoplasmic reticulum contribution to the relaxant effect of cGMP- and cAMP-elevating agents in feline aorta Am J Physiol Heart Circ Physiol 278 6 H1856 H1865 10843882 1:CAS:528:DC%2BD3cXks1ynurc%3D
78. A Gibson I McFadzean P Wallace CP Wayman 1998 Capacitative Ca2+ entry and the regulation of smooth muscle tone Trends Pharmacol Sci 19 7 266 269 9703759 1:CAS:528:DyaK1cXltV2qt70%3D (Pubitemid 28358085)
79. WF Jackson 2000 Ion channels and vascular tone Hypertension 35 1 Pt 2 173 178 10642294 1:CAS:528:DC%2BD3cXpt1ajsg%3D%3D (Pubitemid 30054169)
80. LI Brueggemann BL Martin J Barakat KL Byron LL Cribbs 2005 Low voltage-activated calcium channels in vascular smooth muscle: T-type channels and AVP-stimulated calcium spiking Am J Physiol Heart Circ Physiol 288 2 H923 H935 15498818 1:CAS:528:DC%2BD2MXhsFelsrc%3D
81. JW Putney Jr RR McKay 1999 Capacitative calcium entry channels BioEssays 21 1 38 46 10070252 (Pubitemid 29073017)
82. K Ross M Whitaker NJ Reynolds 2007 Agonist-induced calcium entry correlates with STIM1 translocation J Cell Physiol 211 3 569 576 17299780 1:CAS:528:DC%2BD2sXkvFCnsrs%3D (Pubitemid 46683024)
83. C Randriamampita RY Tsien 1993 Emptying of intracellular Ca2+ stores releases a novel small messenger that stimulates Ca2+ influx Nature 364 6440 809 814 8355806 1:CAS:528:DyaK3sXmt1amu7c%3D (Pubitemid 23261762)
84. T Smani SI Zakharov P Csutora E Leno ES Trepakova VM Bolotina 2004 A novel mechanism for the store-operated calcium influx pathway Nat Cell Biol 6 2 113 120 14730314 1:CAS:528:DC%2BD2cXosFShsg%3D%3D (Pubitemid 38425710)
85. VM Bolotina P Csutora 2005 CIF and other mysteries of the store-operated Ca2+ -entry pathway Trends Biochem Sci 30 7 378 387 15951181 1:CAS:528:DC%2BD2MXlvFaktL8%3D (Pubitemid 40942033)
86. RM Luik MM Wu J Buchanan RS Lewis 2006 The elementary unit of store-operated Ca2+ entry: local activation of CRAC channels by STIM1 at ER-plasma membrane junctions J Cell Biol 174 6 815 825 16966423 1:CAS:528:DC%2BD28XpvVGhurw%3D (Pubitemid 44373731)
87. A Dietrich V Chubanov H Kalwa BR Rost T Gudermann 2006 Cation channels of the transient receptor potential superfamily: their role in physiological and pathophysiological processes of smooth muscle cells Pharmacol Ther 112 3 744 760 16842858 1:CAS:528:DC%2BD28XhtFSksr%2FM (Pubitemid 44573495)
88. GN Huang W Zeng JY Kim JP Yuan L Han S Muallem PF Worley 2006 STIM1 carboxyl-terminus activates native SOC, I(crac) and TRPC1 channels Nat Cell Biol 8 9 1003 1010 16906149 1:CAS:528:DC%2BD28XovFyktrY%3D (Pubitemid 44314732)
89. JJ Lopez GM Salido JA Pariente JA Rosado 2006 Interaction of STIM1 with endogenously expressed human canonical TRP1 upon depletion of intracellular Ca2+ stores J Biol Chem 281 38 28254 28264 16870612 1:CAS:528:DC%2BD28XpsFOqsrw%3D (Pubitemid 44414539)
90. MT Nelson JB Patlak JF Worley NB Standen 1990 Calcium channels, potassium channels, and voltage dependence of arterial smooth muscle tone Am J Physiol 259 C18 C33
91. AD Hughes 1995 Calcium channels in vascular smooth muscle cells J Vasc Res 32 6 353 370 8562808 1:CAS:528:DyaK28Xht12hur4%3D (Pubitemid 26036926)
92. S Moosmang V Schulla A Welling R Feil S Feil JW Wegener F Hofmann N Klugbauer 2003 Dominant role of smooth muscle L-type calcium channel Cav1.2 for blood pressure regulation EMBO J 22 22 6027 6034 14609949 1:CAS:528: DC%2BD3sXptVeqtL0%3D (Pubitemid 37463246)
93. TF McDonald S Pelzer W Trautwein DJ Pelzer 1994 Regulation and modulation of calcium channels in cardiac, skeletal, and smooth muscle cells Physiol Rev 74 365 507 8171118 1:CAS:528:DyaK2cXksl2jtLY%3D (Pubitemid 24127646)
94. Z Xiong N Sperelakis 1995 Regulation of L-type calcium channels of vascular smooth muscle cells J Mol Cell Cardiol 27 1 75 91 7760390 1:CAS:528:DyaK2MXjvVyjur0%3D
95. H Liu Z Xiong N Sperelakis 1997 Cyclic nucleotides regulate the activity of L-type calcium channels in smooth muscle cells from rat portal vein J Mol Cell Cardiol 29 5 1411 1421 9201626 1:CAS:528:DyaK2sXktFOmsbc%3D (Pubitemid 27259654)
96. K Taguchi M Ueda T Kubo 1997 Effects of cAMP and cGMP on L-type calcium channel currents in rat mesenteric artery cells Jpn J Pharmacol 74 2 179 186 9243326 1:CAS:528:DyaK2sXktVOgsbY%3D (Pubitemid 27331144)
97. T Ishikawa JR Hume KD Keef 1993 Regulation of Ca2+ channels by cAMP and cGMP in vascular smooth muscle cells Circ Res 73 6 1128 1137 8222084 1:CAS:528:DyaK2cXivVSmtg%3D%3D
98. V Ruiz-Velasco J Zhong JR Hume KD Keef 1998 Modulation of Ca2+ channels by cyclic nucleotide cross activation of opposing protein kinases in rabbit portal vein Circ Res 82 5 557 565 9529160 1:CAS:528:DyaK1cXitVSktb4%3D (Pubitemid 28129026)
99. Z Xiong N Sperelakis C Fenoglio-Preiser 1994 Regulation of L-type calcium channels by cyclic nucleotides and phosphorylation in smooth muscle cells from rabbit portal vein J Vasc Res 31 5 271 279 7918917 1:CAS:528:DyaK2MXitFahs7o%3D (Pubitemid 24306975)
100. JN Lorenz DR Bielefeld N Sperelakis 1994 Regulation of calcium channel current in A7r5 vascular smooth muscle cells by cyclic nucleotides Am J Physiol 266 6 Pt 1 C1656 C1663 8023895 1:CAS:528:DyaK2cXltlSqsb8%3D
101. H Satoh N Sperelakis 1995 Modulation of L-type Ca2+ current by isoprenaline, carbachol and phorbol ester in cultured rat aortic vascular smooth muscle (A7r5) cells Gen Pharmacol 26 2 369 379 7590090 1:CAS:528: DyaK2MXkvVSjsL8%3D
102. JM Gonzalez LJ Jost D Rouse WN Suki 1996 Plasma membrane and sarcoplasmic reticulum Calcium-ATPase and smooth muscle Miner Electrolyte Metab 22 345 348 8933505 1:CAS:528:DyaK28Xnt1Wjurw%3D (Pubitemid 26370443)
103. S Kobayashi H Kanaide M Nakamura 1985 Cytosolic-free calcium transients in cultured vascular smooth muscle cells: microfluorometric measurements Science 229 4713 553 556 3927484 1:CAS:528:DyaL2MXltFKjsr0%3D (Pubitemid 16239332)
104. SS Rashatwar TL Cornwell TM Lincoln 1987 Effects of 8-bromo-cGMP on Ca2+ levels in vascular smooth muscle cells: possible regulation of Ca2+-ATPase by cGMP-dependent protein kinase Proc Natl Acad Sci USA 84 16 5685 5689 3039502 1:CAS:528:DyaL2sXltlWlsrs%3D
105. LM Popescu C Panoiu M Hinescu O Nutu 1985 The mechanism of cGMP-induced relaxation in vascular smooth muscle Eur J Pharmacol 107 3 393 394 2984014 1:CAS:528:DyaL2MXhtVygs7w%3D (Pubitemid 15161318)
106. K Furukawa H Nakamura 1987 Cyclic GMP regulation of the plasma membrane (Ca2+-Mg2 +)ATPase in vascular smooth muscle J Biochem 101 1 287 290 3032927 1:CAS:528:DyaL2sXpvVCruw%3D%3D (Pubitemid 17218613)
107. M Vrolix L Raeymaekers F Wuytack F Hofmann R Casteels 1988 Cyclic GMP-dependent protein kinase stimulates the plasmalemmal Ca2+ pump of smooth muscle via phosphorylation of phosphatidylinositol Biochem J 255 3 855 863 2850801 1:CAS:528:DyaL1cXmt1Glsbw%3D (Pubitemid 18263950)
108. A Matthew A Shmygol S Wray 2004 Ca2+ entry, efflux and release in smooth muscle Biol Res 37 4 617 624 15709690 1:STN:280:DC%2BD2M%2FotVGqsQ%3D%3D
109. E Karashima J Nishimura T Iwamoto K Hirano M Hirano S Kita M Harada H Kanaide 2007 Involvement of Na + -Ca2+ exchanger in cAMP-mediated relaxation in mice aorta: evaluation using transgenic mice Br J Pharmacol 150 4 434 444 17220909 1:CAS:528:DC%2BD2sXhvVelt7g%3D (Pubitemid 46280657)
110. K Furukawa N Ohshima Y Tawada-Iwata M Shigekawa 1991 Cyclic GMP stimulates Na +/Ca2+ exchange in vascular smooth muscle cells in primary culture J Biol Chem 266 19 12337 12341 1648093 1:CAS:528:DyaK3MXkvV2lu7g%3D (Pubitemid 21907097)
111. PI Aaronson CD Benham 1989 Alterations in [Ca2+]i mediated by sodium-calcium exchange in smooth muscle cells isolated from the guinea-pig ureter J Physiol 416 1 18 2607445 1:STN:280:DyaK3c7ht1Sksg%3D%3D (Pubitemid 19223199)
112. K Furukawa Y Tawada M Shigekawa 1988 Regulation of the plasma membrane Ca2+ pump by cyclic nucleotides in cultured vascular smooth muscle cells J Biol Chem 263 17 8058 8065 2836409 1:CAS:528:DyaL1cXkt1Sks7k%3D
113. JE Brayden 1996 Potassium channels in vascular smooth muscle Clin Exp Pharmacol Physiol 23 1069 1076 8977162 1:CAS:528:DyaK2sXkt1ymsQ%3D%3D (Pubitemid 26426742)
114. EA Ko J Han ID Jung WS Park 2008 Physiological roles of K+ channels in vascular smooth muscle cells J Smooth Muscle Res 44 2 65 81 18552454
115. EA Aiello MP Walsh WC Cole 1995 Phosphorylation by protein kinase A enhances delayed rectifier K+ current in rabbit vascular smooth muscle cells Am J Physiol 268 2 Pt 2 H926 H934 7864221 1:CAS:528:DyaK2MXktFams78%3D
116. EA Aiello AT Malcolm MP Walsh WC Cole 1998 Beta-adrenoceptor activation and PKA regulate delayed rectifier K+ channels of vascular smooth muscle cells Am J Physiol 275 2 Pt 2 H448 H459 9683432 1:CAS:528:DyaK1cXlsVyjsr0%3D
117. K Sathishkumar RG Ross DU Bawankule KK Sardar VR Prakash SK Mishra 2005 Segmental heterogeneity in the mechanism of sodium nitroprusside-induced relaxation in ovine pulmonary artery J Cardiovasc Pharmacol 45 6 491 498 15897774 1:CAS:528:DC%2BD2MXktFyntb4%3D (Pubitemid 40734568)
118. DI Palen S Belmadani PA Lucchesi K Matrougui 2005 Role of SHP-1, Kv.1.2, and cGMP in nitric oxide-induced ERK1/2 MAP kinase dephosphorylation in rat vascular smooth muscle cells Cardiovasc Res 68 2 268 277 15967421 1:CAS:528:DC%2BD2MXhtFWntLjJ (Pubitemid 41428423)
119. NJ Rusch Y Liu KA Pleyte 1996 Mechanisms for regulation of arterial tone by Ca2+ -dependent K + channels in hypertension Clin Exp Pharmacol Physiol 23 12 1077 1081 8977163 1:CAS:528:DyaK2sXkt12gsg%3D%3D (Pubitemid 26426743)
120. J Taniguchi KI Furukawa M Shigekawa 1993 Maxi K+ channels are stimulated by cyclic guanosine monophosphate-dependent protein kinase in canine coronary artery smooth muscle cells Pflugers Arch 423 3-4 167 172 7686645 1:CAS:528:DyaK3sXkvFahs7c%3D (Pubitemid 23137288)
121. H Taguchi DD Heistad T Kitazono FM Faraci 1995 Dilatation of cerebral arterioles in response to activation of adenylate cyclase is dependent on activation of Ca(2+)-dependent K+ channels Circ Res 76 6 1057 1062 7758160 1:CAS:528:DyaK2MXlvVSht7c%3D
122. R Schubert VN Serebryakov H Engel HH Hopp 1996 Iloprost activates KCa channels of vascular smooth muscle cells: role of cAMP-dependent protein kinase Am J Physiol 271 C1203 C1211 8897826 1:CAS:528:DyaK28XmsF2nu7o%3D
123. R Schubert VN Serebryakov H Mewes HH Hopp 1997 Iloprost dilates rat small arteries: role of K(ATP)- and K(Ca)-channel activation by cAMP-dependent protein kinase Am J Physiol 272 3 Pt 2 H1147 H1156 9087587 1:CAS:528: DyaK2sXit1Wms7Y%3D
124. BN Wu CF Chen YR Hong SL Howng YL Lin IJ Chen 2007 Activation of BKCa channels via cyclic AMP- and cyclic GMP-dependent protein kinases by eugenosedin-A in rat basilar artery myocytes Br J Pharmacol 152 3 374 385 17700725 1:CAS:528:DC%2BD2sXhtFSgsLnO
125. SK Fellner WJ Arendshorst 2010 Complex interactions of NO/cGMP/PKG systems on Ca2+ signaling in afferent arteriolar vascular smooth muscle Am J Physiol Heart Circ Physiol 298 1 H144 H151 19880669 1:CAS:528: DC%2BC3cXhsFKls7k%3D
126. CF Liang AL Au SW Leung KF Ng M Feletou YW Kwan RY Man PM Vanhoutte 2010 Endothelium-derived nitric oxide inhibits the relaxation of the porcine coronary artery to natriuretic peptides by desensitizing big conductance calcium-activated potassium channels of vascular smooth muscle J Pharmacol Exp Ther 334 1 223 231 20332186 1:CAS:528:DC%2BC3cXos1Kltb8%3D
127. Y Zhang E Pertens LJ Janssen 2005 8-isoprostaglandin E2 activates Ca2+-dependent K+ current via cyclic AMP signaling pathway in murine renal artery Eur J Pharmacol 520 1-3 22 28 16153635 1:CAS:528:DC%2BD2MXhtVKisLjE (Pubitemid 41375807)
128. SA Barman S Zhu G Han RE White 2003 cAMP activates BKCa channels in pulmonary arterial smooth muscle via cGMP-dependent protein kinase Am J Physiol Lung Cell Mol Physiol 284 6 L1004 L1011 12547730 1:CAS:528:DC%2BD3sXltVensrw%3D
129. SA Barman S Zhu RE White 2004 PKC activates BKCa channels in rat pulmonary arterial smooth muscle via cGMP-dependent protein kinase Am J Physiol 286 6 13
130. D Prieto L Rivera S Benedito P Recio N Villalba M Hernandez A Garcia-Sacristan 2006 Ca2+-activated K+ (KCa) channels are involved in the relaxations elicited by sildenafil in penile resistance arteries Eur J Pharmacol 531 1-3 232 237 16443214 1:CAS:528:DC%2BD28Xhtlejtb8%3D (Pubitemid 43202240)
131. Y Zhang T Tazzeo V Chu LJ Janssen 2006 Membrane potassium currents in human radial artery and their regulation by nitric oxide donor Cardiovasc Res 71 2 383 392 16716281 1:CAS:528:DC%2BD28Xmt1ygtro%3D
132. A Alioua Y Tanaka M Wallner F Hofmann P Ruth P Meera L Toro 1998 The large conductance, voltage-dependent, and calcium-sensitive K+ channel, Hslo, is a target of cGMP-dependent protein kinase phosphorylation in vivo J Biol Chem 273 49 32950 32956 9830046 1:CAS:528:DyaK1cXnvFOms74%3D (Pubitemid 28557688)
133. RE White AB Lee AD Shcherbatko TM Lincoln A Schonbrunn DL Armstrong 1993 Potassium channel stimulation by natriuretic peptides through cGMP-dependent dephosphorylation Nature 361 6409 263 266 7678699 1:CAS:528:DyaK3sXhtFOntb4%3D (Pubitemid 23034477)
134. A Natarajan G Han SY Chen P Yu R White P Jose 2010 The D5 dopamine receptor mediates large-conductance, calcium- and voltage-activated potassium channel activation in human coronary artery smooth muscle cells J Pharmacol Exp Ther 332 2 640 649 19864616 1:CAS:528:DC%2BC3cXltVCktLw%3D
135. J Daut W Maier-Rudolph N von Beckerath G Mehrke K Gunther L Goedel-Meinen 1990 Hypoxic dilation of coronary arteries is mediated by ATP-sensitive potassium channels Science 247 4948 1341 1344 2107575 1:CAS:528: DyaK3cXitlehtLw%3D
136. H Kanatsuka N Sekiguchi K Sato K Akai Y Wang T Komaru K Ashikawa T Takishima 1992 Microvascular sites and mechanisms responsible for reactive hyperemia in the coronary circulation of the beating canine heart Circ Res 71 4 912 922 1516163 1:STN:280:DyaK38zos1KntA%3D%3D
137. H Ishizaka SR Gudi JA Frangos L Kuo 1999 Coronary arteriolar dilation to acidosis: role of ATP-sensitive potassium channels and pertussis toxin-sensitive
138. DW Landry JA Oliver 1992 The ATP-sensitive K+ channel mediates hypotension in endotoxemia and hypoxic lactic acidosis in dog J Clin Invest 89 6 2071 2074 1602014 1:CAS:528:DyaK38XksVGks74%3D
139. Y Miyoshi Y Nakaya T Wakatsuki S Nakaya K Fujino K Saito I Inoue 1992 Endothelin blocks ATP-sensitive K+ channels and depolarizes smooth muscle cells of porcine coronary artery Circ Res 70 3 612 616 1537097 1:CAS:528: DyaK38Xhs1Ojsbo%3D
140. T Wakatsuki Y Nakaya I Inoue 1992 Vasopressin modulates K(+)-channel activities of cultured smooth muscle cells from porcine coronary artery Am J Physiol 263 2 Pt 2 H491 H496 1387293 1:CAS:528:DyaK38Xls1Chtbc%3D
141. JE Brayden 2002 Functional roles of KATP channels in vascular smooth muscle Clin Exp Pharmacol Physiol 29 4 312 316 11985542 1:CAS:528: DC%2BD38XisVKmsL4%3D (Pubitemid 34227066)
142. Y Miyoshi Y Nakaya 1991 Angiotensin II blocks ATP-sensitive K+ channels in porcine coronary artery smooth muscle cells Biochem Biophys Res Commun 181 2 700 706 1755851 1:CAS:528:DyaK38XjsFWnug%3D%3D
143. NN Orie AM Thomas BA Perrino A Tinker LH Clapp 2009 Ca2+/calcineurin regulation of cloned vascular K ATP channels: crosstalk with the protein kinase A pathway Br J Pharmacol 157 4 554 564 19422382 1:CAS:528:DC%2BD1MXptleit7w%3D
144. GC Wellman JM Quayle NB Standen 1998 ATP-sensitive K+ channel activation by calcitonin gene-related peptide and protein kinase A in pig coronary arterial smooth muscle J Physiol 507 Pt 1 117 129 9490826 1:CAS:528:DyaK1cXhslyjtr4%3D (Pubitemid 28102680)
145. T Kleppisch MT Nelson 1995 Adenosine activates ATP-sensitive potassium channels in arterial myocytes via A2 receptors and cAMP-dependent protein kinase Proc Natl Acad Sci USA 92 26 12441 12445 8618917 1:CAS:528:DyaK28Xhtl2ktw%3D%3D (Pubitemid 26014085)
146. C Dart NB Standen 1993 Adenosine-activated potassium current in smooth muscle cells isolated from the pig coronary artery J Physiol 471 767 786 7509875 1:CAS:528:DyaK2cXivVamug%3D%3D (Pubitemid 23345607)
147. JM Quayle AD Bonev JE Brayden MT Nelson 1994 Calcitonin gene-related peptide activated ATP-sensitive K+ currents in rabbit arterial smooth muscle via protein kinase A J Physiol 475 1 9 13 8189394 1:CAS:528:DyaK2cXhvVemu7Y%3D (Pubitemid 24081933)
148. H Miyoshi Y Nakaya 1993 Activation of ATP-sensitive K+ channels by cyclic AMP-dependent protein kinase in cultured smooth muscle cells of porcine coronary artery Biochem Biophys Res Commun 193 1 240 247 8503914 1:CAS:528:DyaK3sXksVWmtbs%3D (Pubitemid 23199938)
149. MT Nelson JM Quayle 1995 Physiological roles and properties of potassium channels in arterial smooth muscle Am J Physiol 268 4 Pt 1 C799 C822 7733230 1:CAS:528:DyaK2MXlt1yju7g%3D
150. NB Standen JM Quayle 1998 K+ channel modulation in arterial smooth muscle Acta Physiol Scand 164 4 549 557 9887977 1:CAS:528:DyaK1MXltFChtA%3D%3D (Pubitemid 29015673)
151. M Kubo Y Nakaya S Matsuoka K Saito Y Kuroda 1994 Atrial natriuretic factor and isosorbide dinitrate modulate the gating of ATP-sensitive K+ channels in cultured vascular smooth muscle cells Circ Res 74 3 471 476 8118955 1:CAS:528:DyaK2cXhvVeqtrY%3D (Pubitemid 24064197)
152. H Miyoshi Y Nakaya H Moritoki 1994 Nonendothelial-derived nitric oxide activates the ATP-sensitive K+ channel of vascular smooth muscle cells FEBS Lett 345 1 47 49 8194598 1:CAS:528:DyaK2cXktVKjtbg%3D (Pubitemid 24154663)
153. ME Murphy JE Brayden 1995 Nitric oxide hyperpolarizes rabbit mesenteric arteries via ATP-sensitive potassium channels J Physiol 486 Pt 1 47 58 7562643 1:CAS:528:DyaK2MXmvFOqtrc%3D
154. A Eckly-Michel V Martin C Lugnier 1997 Involvement of cyclic nucleotide-dependent protein kinases in cyclic AMP-mediated vasorelaxation Br J Pharmacol 122 158 164 9298542 1:CAS:528:DyaK2sXmt1ajt7k%3D (Pubitemid 27376033)
155. H Jiang JL Colbran SH Francis JD Corbin 1992 Direct evidence of cross-activation of cGMP-dependent protein kinase by cAMP in pig coronary arteries J Biol Chem 267 1015 1019 1309758 1:CAS:528:DyaK38XotFWkuw%3D%3D
156. W Zhao J Zhang Y Lu R Wang 2001 The vasorelaxant effect of H(2)S as a novel endogenous gaseous K(ATP) channel opener EMBO J 20 21 6008 6016 11689441 1:CAS:528:DC%2BD3MXovVSitL8%3D (Pubitemid 33049276)
157. G Tang L Wu W Liang R Wang 2005 Direct stimulation of K(ATP) channels by exogenous and endogenous hydrogen sulfide in vascular smooth muscle cells Mol Pharmacol 68 6 1757 1764 16150926 1:CAS:528:DC%2BD2MXht1yksbfK (Pubitemid 41654358)
158. M Bucci A Papapetropoulos V Vellecco Z Zhou A Pyriochou C Roussos F Roviezzo V Brancaleone G Cirino 2011 Hydrogen sulfide is an endogenous inhibitor of phosphodiesterase activity Arterioscler Thromb Vasc Biol 30 10 1998 2004
159. CG Sobey 2001 Potassium channel function in vascular disease Arterioscler Thromb Vasc Biol 21 1 28 38 11145930 1:CAS:528:DC%2BD3MXnvFGitw%3D%3D (Pubitemid 32061924)
160. JJ Zaritsky DM Eckman GC Wellman MT Nelson TL Schwarz 2000 Targeted disruption of Kir2.1 and Kir2.2 genes reveals the essential role of the inwardly rectifying K(+) current in K(+)-mediated vasodilation Circ Res 87 2 160 166 10904001 1:CAS:528:DC%2BD3cXlt1aiur0%3D (Pubitemid 30616913)
161. PJ Best JC Burnett SH Wilson DR Holmes Jr A Lerman 2002 Dendroaspis natriuretic peptide relaxes isolated human arteries and veins Cardiovasc Res 55 2 375 384 12123777 1:CAS:528:DC%2BD38Xlt12ksLc%3D (Pubitemid 34775288)
162. R Schubert U Krien I Wulfsen D Schiemann G Lehmann N Ulfig RW Veh JR Schwarz H Gago 2004 Nitric oxide donor sodium nitroprusside dilates rat small arteries by activation of inward rectifier potassium channels Hypertension 43 4 891 896 14993195 1:CAS:528:DC%2BD2cXit12mtr4%3D (Pubitemid 38405606)
163. WS Park J Han N Kim JH Ko SJ Kim YE Earm 2005 Activation of inward rectifier K+ channels by hypoxia in rabbit coronary arterial smooth muscle cells Am J Physiol Heart Circ Physiol 289 6 H2461 H2467 16284107 1:CAS:528: DC%2BD28XlslGmtA%3D%3D
164. YK Son WS Park JH Ko J Han N Kim YE Earm 2005 Protein kinase A-dependent activation of inward rectifier potassium channels by adenosine in rabbit coronary smooth muscle cells Biochem Biophys Res Commun 337 4 1145 1152 16226714 1:CAS:528:DC%2BD2MXhtFKhs7bP (Pubitemid 41505245)
165. NN Orie CH Fry LH Clapp 2006 Evidence that inward rectifier K+ channels mediate relaxation by the PGI2 receptor agonist cicaprost via a cyclic AMP-independent mechanism Cardiovasc Res 69 1 107 115 16183044 1:CAS:528:DC%2BD2MXhtlGisb7F (Pubitemid 41814816)
166. JT Stull MG Tansey DC Tang RA Word KE Kamm 1993 Phosphorylation of myosin light chain kinase: a cellular mechanism for Ca2+ desensitization Mol Cell Biochem 127-128 229 237 7935354 (Pubitemid 24032669)
167. MA Conti RS Adelstein 1981 The relationship between calmodulin binding and phosphorylation of smooth muscle myosin kinase by the catalytic subunit of 3':5' cAMP-dependent protein kinase J Biol Chem 256 7 3178 3181 6259152 1:CAS:528:DyaL3MXhsFalsr0%3D (Pubitemid 11076973)
168. DA van Riper NL McDaniel CM Rembold 1997 Myosin light chain kinase phosphorylation in nitrovasodilator induced swine carotid artery relaxation Biochim Biophys Acta 1355 3 323 330 9061003 (Pubitemid 27091388)
169. HK Surks N Mochizuki Y Kasai SP Georgescu KM Tang M Ito TM Lincoln ME Mendelsohn 1999 Regulation of myosin phosphatase by a specific interaction with cGMP-dependent protein kinase Ialpha Science 286 5444 1583 1587 10567269 1:CAS:528:DyaK1MXns1aisb0%3D
170. K Nakamura Y Koga H Sakai K Homma M Ikebe 2007 cGMP-dependent relaxation of smooth muscle is coupled with the change in the phosphorylation of myosin phosphatase Circ Res 101 7 712 722 17673671 1:CAS:528:DC%2BD2sXhtVOrsL7N (Pubitemid 47494102)
171. T Kitazawa S Semba YH Huh K Kitazawa M Eto 2009 Nitric oxide-induced biphasic mechanism of vascular relaxation via dephosphorylation of CPI-17 and MYPT1 J Physiol 587 Pt 14 3587 3603 19470783 1:CAS:528:DC%2BD1MXpt1WrsL0%3D
172. AA Wooldridge JA MacDonald F Erdodi C Ma MA Borman DJ Hartshorne TA Haystead 2004 Smooth muscle phosphatase is regulated in vivo by exclusion of phosphorylation of threonine 696 of MYPT1 by phosphorylation of Serine 695 in response to cyclic nucleotides J Biol Chem 279 33 34496 34504 15194681 1:CAS:528:DC%2BD2cXmvFenurk%3D (Pubitemid 39318077)
173. AV Somlyo 2007 Cyclic GMP regulation of myosin phosphatase: a new piece for the puzzle? Circ Res 101 7 645 647 17901367 1:CAS:528:DC%2BD1cXjsFWi (Pubitemid 47494093)
174. X Wu TA Haystead RK Nakamoto AV Somlyo AP Somlyo 1998 Acceleration of myosin light chain dephosphorylation and relaxation of smooth muscle by telokin. Synergism with cyclic nucleotide-activated kinase J Biol Chem 273 18 11362 11369 9556631 1:CAS:528:DyaK1cXjtFGrt7g%3D (Pubitemid 28204992)
175. MA Borman JA MacDonald TA Haystead 2004 Modulation of smooth muscle contractility by CHASM, a novel member of the smoothelin family of proteins FEBS Lett 573 1-3 207 213 15327999 1:CAS:528:DC%2BD2cXmvFyrt7c%3D (Pubitemid 39141059)
176. AS Khromov H Wang N Choudhury M McDuffie BP Herring R Nakamoto GK Owens AP Somlyo AV Somlyo 2006 Smooth muscle of telokin-deficient mice exhibits increased sensitivity to Ca2+ and decreased cGMP-induced relaxation Proc Natl Acad Sci USA 103 7 2440 2445 16461919 1:CAS:528:DC%2BD28XhslGjtLk%3D (Pubitemid 43271688)
177. V Sauzeau H Le Jeune C Cario-Toumaniantz A Smolenski SM Lohmann J Bertoglio P Chardin P Pacaud G Loirand 2000 Cyclic GMP-dependent protein kinase signaling pathway inhibits RhoA-induced Ca2+ sensitization of contraction in vascular smooth muscle J Biol Chem 275 28 21722 21729 10783386 1:CAS:528:DC%2BD3cXkvFGit74%3D
178. S Sakurada N Takuwa N Sugimoto Y Wang M Seto Y Sasaki Y Takuwa 2003 Ca2+ -dependent activation of Rho and Rho kinase in membrane depolarization-induced and receptor stimulation-induced vascular smooth muscle contraction Circ Res 93 6 548 556 12919947 1:CAS:528:DC%2BD3sXntFCmt7g%3D (Pubitemid 37163235)
179. G Loirand P Guerin P Pacaud 2006 Rho kinases in cardiovascular physiology and pathophysiology Circ Res 98 3 322 334 16484628 1:CAS:528: DC%2BD28Xht1Cmtbg%3D
180. AJ Santos-Silva E Cairrão I Verde 2010 Study of the mechanisms regulating human umbilical artery contractility Health (N. Y). 2 4 321 331
181. J Bonnevier A Arner 2004 Actions downstream of cyclic GMP/protein kinase G can reverse protein kinase C-mediated phosphorylation of CPI-17 and Ca2+ sensitization in smooth muscle J Biol Chem 279 28 28998 29003 15123611 1:CAS:528:DC%2BD2cXlsVCnt78%3D (Pubitemid 38915769)
182. SS Bolz L Vogel D Sollinger R Derwand C De Wit G Loirand U Pohl 2003 Nitric oxide-induced decrease in calcium sensitivity of resistance arteries is attributable to activation of the myosin light chain phosphatase and antagonized by the RhoA/Rho kinase pathway Circulation 107 24 3081 3087 12796138 1:CAS:528:DC%2BD3sXksF2nur0%3D (Pubitemid 36758983)
183. DA Woodrum CM Brophy CJ Wingard A Beall H Rasmussen 1999 Phosphorylation events associated with cyclic nucleotide-dependent inhibition of smooth muscle contraction Am J Physiol 277 3 Pt 2 H931 H939 10484413 1:CAS:528: DyaK1MXmt1Gjtrg%3D
184. AC Beall K Kato JR Goldenring H Rasmussen CM Brophy 1997 Cyclic nucleotide-dependent vasorelaxation is associated with the phosphorylation of a small heat shock-related protein J Biol Chem 272 17 11283 11287 9111032 1:CAS:528:DyaK2sXjtVamtb8%3D (Pubitemid 27184128)
185. S Salinthone M Tyagi WT Gerthoffer 2008 Small heat shock proteins in smooth muscle Pharmacol Ther 119 1 44 54 18579210 1:CAS:528:DC%2BD1cXotlaitr0%3D
186. A Beall D Bagwell D Woodrum TA Stoming K Kato A Suzuki H Rasmussen CM Brophy 1999 The small heat shock-related protein, HSP20, is phosphorylated on serine 16 during cyclic nucleotide-dependent relaxation J Biol Chem 274 16 11344 11351 10196226 1:CAS:528:DyaK1MXis1GmtL4%3D
187. CM Rembold DB Foster JD Strauss CJ Wingard JE Eyk 2000 cGMP-mediated phosphorylation of heat shock protein 20 may cause smooth muscle relaxation without myosin light chain dephosphorylation in swine carotid artery J Physiol 524 Pt 3 865 878 10790164 1:CAS:528:DC%2BD3cXjvFGgtrs%3D (Pubitemid 30303631)
188. D Woodrum W Pipkin D Tessier P Komalavilas CM Brophy 2003 Phosphorylation of the heat shock-related protein, HSP20, mediates cyclic nucleotide-dependent relaxation J Vasc Surg 37 4 874 881 12663991 (Pubitemid 36373378)
189. Fan GC, Kranias EG (2010) Small heat shock protein 20 (HspB6) in cardiac hypertrophy and failure. J Mol Cell Cardiol
190. CM Brophy S Lamb A Graham 1999 The small heat shock-related protein-20 is an actin-associated protein J Vasc Surg 29 2 326 333 9950990 1:STN:280:DyaK1M7jslyksA%3D%3D (Pubitemid 29085292)
191. CR Flynn CM Brophy EJ Furnish P Komalavilas D Tessier J Thresher L Joshi 2005 Transduction of phosphorylated heat shock-related protein 20, HSP20, prevents vasospasm of human umbilical artery smooth muscle J Appl Physiol 98 5 1836 1845 15829720 1:CAS:528:DC%2BD2MXktlOgsb0%3D (Pubitemid 40570797)
192. CM Brophy M Dickinson D Woodrum 1999 Phosphorylation of the small heat shock-related protein, HSP20, in vascular smooth muscles is associated with changes in the macromolecular associations of HSP20 J Biol Chem 274 10 6324 6329 10037721 1:CAS:528:DyaK1MXhs1eruro%3D (Pubitemid 29111044)
193. GJ Kargacin PH Cooke SB Abramson FS Fay 1989 Periodic organization of the contractile apparatus in smooth muscle revealed by the motion of dense bodies in single cells J Cell Biol 108 4 1465 1475 2494193 1:STN:280: DyaL1M7nsV2rsg%3D%3D (Pubitemid 19097051)
194. CM Dreiza CM Brophy P Komalavilas EJ Furnish L Joshi MA Pallero JE Murphy-Ullrich M von Rechenberg YS Ho B Richardson N Xu Y Zhen JM Peltier A Panitch 2005 Transducible heat shock protein 20 (HSP20) phosphopeptide alters cytoskeletal dynamics FASEB J 19 2 261 263 15598710 1:CAS:528: DC%2BD2MXhtFehs7o%3D (Pubitemid 40189275)
195. JE Murphy-Ullrich MA Pallero N Boerth JA Greenwood TM Lincoln TL Cornwell 1996 Cyclic GMP-dependent protein kinase is required for thrombospondin and tenascin mediated focal adhesion disassembly J Cell Sci 109 Pt 10 2499 2508 8923211 1:CAS:528:DyaK28Xmslemsrc%3D (Pubitemid 26377525)
196. LRV Castro I Verde DMF Cooper R Fischmeister 2006 Cyclic GMP compartmentation in rat cardiac myocytes Circulation 113 2221 2228 16651469 1:CAS:528:DC%2BD28XktVWhtLg%3D
197. M Conti J Beavo 2007 Biochemistry and physiology of cyclic nucleotide phosphodiesterases: essential components in cyclic nucleotide signaling Annu Rev Biochem 76 481 511 17376027 1:CAS:528:DC%2BD2sXhtVehtb%2FE
198. NK Vo JM Gettemy VM Coghlan 1998 Identification of cGMP-dependent protein kinase anchoring proteins (GKAPs) Biochem Biophys Res Commun 246 3 831 835 9618298 1:CAS:528:DyaK1cXjsFGrsrs%3D (Pubitemid 28420944)
199. JD Corbin PH Sugden TM Lincoln SL Keely 1977 Compartmentalization of adenosine 3':5'-monophosphate and adenosine 3':5'-monophosphate-dependent protein kinase in heart tissue J Biol Chem 252 11 3854 3861 16921 1:CAS:528:DyaE2sXks1Cntbk%3D (Pubitemid 8127237)
200. M Zaccolo T Pozzan 2002 Discrete microdomains with high concentration of cAMP in stimulated rat neonatal cardiac myocytes Science 295 5560 1711 1715 11872839 1:CAS:528:DC%2BD38Xhslehs7s%3D (Pubitemid 34202906)
201. Yan C, Nagel DJ, Jeon K (2007) In: Beavo J, Francis S, Houslay M (eds) Cyclic nucleotide phosphodiesterases in health and disease. CRC Press, Taylor & Francis Group, Boca Raton, pp 465-484
202. D Kim SD Rybalkin X Pi Y Wang C Zhang T Munzel JA Beavo BC Berk C Yan 2001 Upregulation of phosphodiesterase 1A1 expression is associated with the development of nitrate tolerance Circulation 104 19 2338 2343 11696475 1:CAS:528:DC%2BD3MXpt1Wltrs%3D (Pubitemid 33049518)
203. DJ Nagel T Aizawa KI Jeon W Liu A Mohan H Wei JM Miano VA Florio P Gao VA Korshunov BC Berk C Yan 2006 Role of nuclear Ca2+/calmodulin-stimulated phosphodiesterase 1A in vascular smooth muscle cell growth and survival Circ Res 98 6 777 784 16514069 1:CAS:528:DC%2BD28XislCltr8%3D
204. SM Cawley CL Sawyer KF Brunelle A van der Vliet WR Dostmann 2007 Nitric oxide-evoked transient kinetics of cyclic GMP in vascular smooth muscle cells Cell Signal 19 5 1023 1033 17207606 1:CAS:528:DC%2BD2sXjsVSrurY%3D (Pubitemid 46436439)
205. LW Nausch J Ledoux AD Bonev MT Nelson WR Dostmann 2008 Differential patterning of cGMP in vascular smooth muscle cells revealed by single GFP-linked biosensors Proc Natl Acad Sci USA 105 1 365 370 18165313 1:CAS:528: DC%2BD1cXpvFKgsg%3D%3D
206. LA Piggott KA Hassell Z Berkova AP Morris M Silberbach TC Rich 2006 Natriuretic peptides and nitric oxide stimulate cGMP synthesis in different cellular compartments J Gen Physiol 128 1 3 14 16769793 1:CAS:528: DC%2BD28XnsFWitro%3D (Pubitemid 43967547)
207. R Gros Q Ding J Chorazyczewski JG Pickering LE Limbird RD Feldman 2006 Adenylyl cyclase isoform-selective regulation of vascular smooth muscle proliferation and cytoskeletal reorganization Circ Res 99 8 845 852 16973907 1:CAS:528:DC%2BD28XhtVKjtL7E (Pubitemid 44556383)
208. JA Beavo LL Brunton 2002 Cyclic nucleotide research-still expanding after half a century Nat Rev Mol Cell Biol 3 9 710 718 12209131 1:CAS:528: DC%2BD38Xmslansrk%3D (Pubitemid 34987792)
209. W Wong JD Scott 2004 AKAP signalling complexes: focal points in space and time Nat Rev Mol Cell Biol 5 12 959 970 15573134 1:CAS:528:DC%2BD2cXhtVarsbzJ (Pubitemid 39611533)
210. J Zhong JR Hume KD Keef 1999 Anchoring protein is required for cAMP-dependent stimulation of L-type Ca2+ channels in rabbit portal vein Am J Physiol 277 4 Pt 1 C840 C844 10516114 1:CAS:528:DyaK1MXntFCjtr0%3D
211. Y Hayabuchi C Dart NB Standen 2001 Evidence for involvement of A-kinase anchoring protein in activation of rat arterial K(ATP) channels by protein kinase A J Physiol 536 Pt 2 421 427 11600677 1:CAS:528:DC%2BD3MXovVyhurY%3D (Pubitemid 32976123)
212. C Indolfi E Stabile C Coppola A Gallo C Perrino G Allevato L Cavuto D Torella E Di Lorenzo G Troncone A Feliciello E Avvedimento M Chiariello 2001 Membrane-bound protein kinase A inhibits smooth muscle cell proliferation in vitro and in vivo by amplifying cAMP-protein kinase A signals Circ Res 88 3 319 324 11179200 1:CAS:528:DC%2BD3MXhtlyksLY%3D (Pubitemid 32173756)
213. V Michel M Bakovic 2007 Lipid rafts in health and disease Biol Cell 99 3 129 140 17064251 1:CAS:528:DC%2BD2sXhslCksb0%3D (Pubitemid 46380925)
214. LJ Sampson Y Hayabuchi NB Standen C Dart 2004 Caveolae localize protein kinase A signaling to arterial ATP-sensitive potassium channels Circ Res 95 10 1012 1018 15499025 1:CAS:528:DC%2BD2cXpt1GhsLk%3D (Pubitemid 39532331)
215. RG Anderson 1998 The caveolae membrane system Annu Rev Biochem 67 199 225 9759488 1:CAS:528:DyaK1cXlsFOmsL0%3D (Pubitemid 28411129)
216. M Drab P Verkade M Elger M Kasper M Lohn B Lauterbach J Menne C Lindschau F Mende FC Luft A Schedl H Haller TV Kurzchalia 2001 Loss of caveolae, vascular dysfunction, and pulmonary defects in caveolin-1 gene-disrupted mice Science 293 5539 2449 2452 11498544 1:CAS:528:DC%2BD3MXntlKjs7s%3D (Pubitemid 32917325)
217. YY Zhao Y Liu RV Stan L Fan Y Gu N Dalton PH Chu K Peterson J Ross Jr KR Chien 2002 Defects in caveolin-1 cause dilated cardiomyopathy and pulmonary hypertension in knockout mice Proc Natl Acad Sci USA 99 17 11375 11380 12177436 1:CAS:528:DC%2BD38XmslSmu7w%3D (Pubitemid 34920933)
218. B Razani JA Engelman XB Wang W Schubert XL Zhang CB Marks F Macaluso RG Russell M Li RG Pestell D Di Vizio H Hou Jr B Kneitz G Lagaud GJ Christ W Edelmann MP Lisanti 2001 Caveolin-1 null mice are viable but show evidence of hyperproliferative and vascular abnormalities J Biol Chem 276 41 38121 38138 11457855 1:CAS:528:DC%2BD3MXotFOrurk%3D
219. JP Gratton P Bernatchez WC Sessa 2004 Caveolae and caveolins in the cardiovascular system Circ Res 94 11 1408 1417 15192036 1:CAS:528: DC%2BD2cXksF2lt70%3D (Pubitemid 38780313)
220. A Bergdahl K Sward 2004 Caveolae-associated signalling in smooth muscle Can J Physiol Pharmacol 82 5 289 299 15213728 1:CAS:528:DC%2BD2cXmtFWhs7w%3D (Pubitemid 39093694)