Resveratrol preserves myocardial function and perfusion in remote nonischemic myocardium in a swine model of metabolic syndrome

Journal of the American College of Surgeons

Volumn 215, Issue 5, 2012, Pages 681-689

  Robich, Michael P ^a,b   Chu, Louis M ^a   Burgess, Thomas A ^b   Feng, Jun ^b   Han, Yuchi ^a   Nezafat, Reza ^a   Leber, Michael P ^b   Laham, Roger J ^a   Manning, Warren J ^a   Sellke, Frank W ^b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b BROWN UNIVERSITY   (United States)

Author keywords

AMP activated protein kinase; AMPK; cardiac magnetic resonance imaging; CMR; glucose transporter; GLUT; HCD; HCD R; high cholesterol diet; high cholesterol diet + resveratrol; LAD; LCx; left anterior descending coronary artery; left circumflex coronary artery; left ventricle; LV; metabolic syndrome; MetS; vascular endothelial growth factor; VEGF

Indexed keywords

ADENYLATE KINASE; CARNITINE PALMITOYLTRANSFERASE I; ENDOTHELIAL NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; RESVERATROL; SIRTUIN 1; VASCULOTROPIN;

ANGIOCARDIOGRAPHY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARDIOVASCULAR MAGNETIC RESONANCE; CELL DENSITY; CELL DIVISION; CHOLESTEROL DIET; CONTROLLED STUDY; DIETARY INTAKE; ENDOTHELIUM CELL; EXPERIMENTAL PIG; FUNCTIONAL MAGNETIC RESONANCE IMAGING; HEART LEFT VENTRICLE CONTRACTION; HEART LEFT VENTRICLE FUNCTION; HEART MUSCLE; HEART MUSCLE BLOOD FLOW; HEART MUSCLE CELL; HEART MUSCLE ISCHEMIA; HEART MUSCLE PERFUSION; METABOLIC SYNDROME X; MICROVASCULATURE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANIMALS; ANTIOXIDANTS; BIOLOGICAL MARKERS; BLOTTING, WESTERN; CORONARY VESSELS; DIET, HIGH-FAT; DISEASE MODELS, ANIMAL; FLUORESCENT ANTIBODY TECHNIQUE; HEART; MAGNETIC RESONANCE IMAGING; METABOLIC SYNDROME X; MYOCARDIAL ISCHEMIA; MYOCARDIUM; OXIDATIVE STRESS; STILBENES; SWINE; VENTRICULAR FUNCTION, LEFT;

EID: 84867883189     PISSN: 10727515     EISSN: 18791190     Source Type: Journal    
DOI: 10.1016/j.jamcollsurg.2012.06.417     Document Type: Article

References (25)

1. R.H. Eckel, S.M. Grundy, P.Z. Zimmet The metabolic syndrome Lancet 365 2005 1415 1428
2. S.M. Grundy, H.B. Brewer Jr, J.I. Cleeman Definition of metabolic syndrome: Report of the National Heart, Lung, and Blood Institute/American Heart Association conference on scientific issues related to definition Circulation 109 2004 433 438
3. J. Arnlov, E. Ingelsson, J. Sundstrom, L. Lind Impact of body mass index and the metabolic syndrome on the risk of cardiovascular disease and death in middle-aged men Circulation 121 2010 230 236
4. M. Boodhwani, P. Voisine, M. Ruel Comparison of vascular endothelial growth factor and fibroblast growth factor-2 in a swine model of endothelial dysfunction Eur J Cardiothorac Surg 33 2008 645 650 discussion 251-252
5. N.R. Sodha, R.T. Clements, M. Boodhwani Endostatin and angiostatin are increased in diabetic patients with coronary artery disease and associated with impaired coronary collateral formation Am J Physiol Heart Circ Physiol 296 2009 H428 H434
6. A.C. Cordova, L.S. Jackson, D.W. Berke-Schlessel, B.E. Sumpio The cardiovascular protective effect of red wine J Am Coll Surg 200 2005 428 439
7. S. Lavu, O. Boss, P.J. Elliott, P.D. Lambert Sirtuins-novel therapeutic targets to treat age-associated diseases Nat Rev Drug Discov 7 2008 841 853
8. S.V. Penumathsa, S. Koneru, S.M. Samuel Strategic targets to induce neovascularization by resveratrol in hypercholesterolemic rat myocardium: role of caveolin-1, endothelial nitric oxide synthase, hemeoxygenase-1, and vascular endothelial growth factor Free Radic Biol Med 45 2008 1027 1034
9. T. Walle, F. Hsieh, M.H. DeLegge High absorption but very low bioavailability of oral resveratrol in humans Drug Metab Dispos 32 2004 1377 1382
10. M.P. Robich, R. Matyal, L.M. Chu Effects of neuropeptide Y on collateral development in a swine model of chronic myocardial ischemia J Mol Cell Cardiol 49 2010 1022 1030
11. S. Ryf, K.V. Kissinger, M.A. Spiegel Spiral MR myocardial tagging Magn Reson Med 51 2004 237 242
12. C. Canto, J. Auwerx PGC-1alpha, SIRT1 and AMPK, an energy sensing network that controls energy expenditure Curr Opin Lipidol 20 2009 98 105
13. J.H. Um, S.J. Park, H. Kang AMP-activated protein kinase-deficient mice are resistant to the metabolic effects of resveratrol Diabetes 59 2010 554 563
14. M.P. Robich, R.M. Osipov, L.M. Chu Resveratrol modifies risk factors for coronary artery disease in swine with metabolic syndrome and myocardial ischemia Eur J Pharmacol 664 2011 45 53
15. J.T. Hwang, D.Y. Kwon, O.J. Park, M.S. Kim Resveratrol protects ROS-induced cell death by activating AMPK in H9c2 cardiac muscle cells Genes Nutr 2 2008 323 326
16. C.R. Bruce, A.J. Hoy, N. Turner Overexpression of carnitine palmitoyltransferase-1 in skeletal muscle is sufficient to enhance fatty acid oxidation and improve high-fat diet-induced insulin resistance Diabetes 58 2009 550 558
17. S. Boudina, E.D. Abel Diabetic cardiomyopathy revisited Circulation 115 2007 3213 3223
18. D.P. Dutka, M. Pitt, D. Pagano Myocardial glucose transport and utilization in patients with type 2 diabetes mellitus, left ventricular dysfunction, and coronary artery disease J Am Coll Cardiol 48 2006 2225 2231
19. Z. Arany, H. He, J. Lin Transcriptional coactivator PGC-1 alpha controls the energy state and contractile function of cardiac muscle Cell Metab 1 2005 259 271
20. J.T. Rodgers, C. Lerin, W. Haas Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1 Nature 434 2005 113 118
21. M.P. Robich, R.M. Osipov, L.M. Chu Temporal and spatial changes in collateral formation and function during chronic myocardial ischemia J Am Coll Surg 211 2010 470 480
22. K.D. Boudoulas, A.K. Hatzopoulos Cardiac repair and regeneration: the Rubik's cube of cell therapy for heart disease Dis Model Mech 2 2009 344 358
23. M. Boodhwani, N.R. Sodha, S. Mieno Functional, cellular, and molecular characterization of the angiogenic response to chronic myocardial ischemia in diabetes Circulation 116 2007 I31 I37
24. C. Marchesi, T. Ebrahimian, O. Angulo Endothelial nitric oxide synthase uncoupling and perivascular adipose oxidative stress and inflammation contribute to vascular dysfunction in a rodent model of metabolic syndrome Hypertension 54 2009 1384 1392
25. O.R. Robich MP, R. Nezafat, J. Feng Resveratrol improves myocardial perfusion in a swine model of hypercholesterolemia and chronic myocardial ischemia Circulation 122 11 Supp 2010 S142 S149