메뉴 건너뛰기




Volumn 3, Issue 4, 2014, Pages 670-723

DNA Modifications: Function and Applications in Normal and Disease States

Author keywords

5 hydroxymethylcytosine; 5 methylcytosine; Biomarkers; Brain development; Diabetes; DNA methylation; Methyl binding proteins; Neurological disorders; Teratogens

Indexed keywords


EID: 84908301632     PISSN: None     EISSN: 20797737     Source Type: Journal    
DOI: 10.3390/biology3040670     Document Type: Review
Times cited : (116)

References (285)
  • 1
    • 13144259698 scopus 로고    scopus 로고
    • Friedrich Miescher and the discovery of DNA
    • Dahm, R. Friedrich Miescher and the discovery of DNA. Dev. Biol. 2005, 278, 274-288.
    • (2005) Dev. Biol. , vol.278 , pp. 274-288
    • Dahm, R.1
  • 5
    • 0011923583 scopus 로고
    • Distribution of 5-methylcytosine in chromatin
    • Razin, A.; Cedar, H. Distribution of 5-methylcytosine in chromatin. Proc. Natl. Acad. Sci. USA 1977, 74, 2725-2728.
    • (1977) Proc. Natl. Acad. Sci. USA , vol.74 , pp. 2725-2728
    • Razin, A.1    Cedar, H.2
  • 7
    • 0019318994 scopus 로고
    • DNA methylation and gene function
    • Razin, A.; Riggs, A. DNA methylation and gene function. Science 1980, 2010, 604-610.
    • (1980) Science , vol.2010 , pp. 604-610
    • Razin, A.1    Riggs, A.2
  • 9
    • 78149430876 scopus 로고    scopus 로고
    • Molecular coupling of DNA methylation and histone methylation
    • Hashimoto, H.; Vertino, P.M.; Cheng, X. Molecular coupling of DNA methylation and histone methylation. Epigenomics 2010, 2, 657-669.
    • (2010) Epigenomics , vol.2 , pp. 657-669
    • Hashimoto, H.1    Vertino, P.M.2    Cheng, X.3
  • 10
    • 84873498678 scopus 로고    scopus 로고
    • Ing1 functions in DNA demethylation by directing Gadd45a to H3K4me3
    • Schäfer, A.; Karaulanov, E.; Stapf, U.; Döderlein, G.; Niehrs, C. Ing1 functions in DNA demethylation by directing Gadd45a to H3K4me3. Genes. Dev. 2013, 27, 261-273.
    • (2013) Genes. Dev. , vol.27 , pp. 261-273
    • Schäfer, A.1    Karaulanov, E.2    Stapf, U.3    Döderlein, G.4    Niehrs, C.5
  • 11
    • 79960621198 scopus 로고    scopus 로고
    • Sgf29 binds histone H3K4me2/3 and is required for SAGA complex recruitment and histone H3 acetylation
    • Bian, C.; Xu, C.; Ruan, J.; Lee, K.K.; Burke, T.L.; Tempel, W.; Barsyte, D.; Li, J.; Wu, M.; Zhou, B.O.; et al. Sgf29 binds histone H3K4me2/3 and is required for SAGA complex recruitment and histone H3 acetylation. EMBO J. 2011, 30, 2829-2842.
    • (2011) EMBO J. , vol.30 , pp. 2829-2842
    • Bian, C.1    Xu, C.2    Ruan, J.3    Lee, K.K.4    Burke, T.L.5    Tempel, W.6    Barsyte, D.7    Li, J.8    Wu, M.9    Zhou, B.O.10
  • 12
    • 84880730339 scopus 로고    scopus 로고
    • A dual role for SAGA-associated factor 29 (SGF29) in ER stress survival by coordination of both histone H3 acetylation and histone H3 lysine-4 trimethylation
    • Schram, A.W.; Baas, R.; Jansen, P.W.; Riss, A.; Tora, L.; Vermeulen, M.; Timmers, H.T. A dual role for SAGA-associated factor 29 (SGF29) in ER stress survival by coordination of both histone H3 acetylation and histone H3 lysine-4 trimethylation. PLoS One 2013, 8, e70035.
    • (2013) PLoS One , vol.8
    • Schram, A.W.1    Baas, R.2    Jansen, P.W.3    Riss, A.4    Tora, L.5    Vermeulen, M.6    Timmers, H.T.7
  • 15
    • 79955538247 scopus 로고    scopus 로고
    • Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain
    • Guo, J.U.; Su, Y.; Zhong, C.; Ming, G.; Song, H. Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain. Cell 2011, 145, 423-434.
    • (2011) Cell , vol.145 , pp. 423-434
    • Guo, J.U.1    Su, Y.2    Zhong, C.3    Ming, G.4    Song, H.5
  • 16
    • 84867396351 scopus 로고    scopus 로고
    • Mechanisms of DNA methylation and demethylation in mammals
    • Auclair, G.; Weber, M. Mechanisms of DNA methylation and demethylation in mammals. Biochimie 2012, 94, 2202-2211.
    • (2012) Biochimie , vol.94 , pp. 2202-2211
    • Auclair, G.1    Weber, M.2
  • 17
    • 79955004702 scopus 로고    scopus 로고
    • Advances in DNA methylation: 5-hydroxymethylcytosine revisited
    • Dahl, C.; Grønbæk, K.; Guldberg, P. Advances in DNA methylation: 5-hydroxymethylcytosine revisited. Clin. Chim. Acta 2011, 412, 831-836.
    • (2011) Clin. Chim. Acta , vol.412 , pp. 831-836
    • Dahl, C.1    Grønbæk, K.2    Guldberg, P.3
  • 18
    • 84869059680 scopus 로고    scopus 로고
    • Karpf, A.R., Ed.; Springer New York: New York, NY, USA
    • Ehrlich, M.; Lacey, M. Epigenetic Alterations in Oncogenesis; Karpf, A.R., Ed.; Springer New York: New York, NY, USA, 2013; Volume 754, pp. 31-56.
    • (2013) Epigenetic Alterations in Oncogenesis , vol.754 , pp. 31-56
    • Ehrlich, M.1    Lacey, M.2
  • 19
    • 84886860116 scopus 로고    scopus 로고
    • TET enzymes, TDG and the dynamics of DNA demethylation
    • Kohli, R.M.; Zhang, Y. TET enzymes, TDG and the dynamics of DNA demethylation. Nature 2013, 502, 472-479.
    • (2013) Nature , vol.502 , pp. 472-479
    • Kohli, R.M.1    Zhang, Y.2
  • 20
    • 70350046301 scopus 로고    scopus 로고
    • Rethinking how DNA methylation patterns are maintained
    • Jones, P.A; Liang, G. Rethinking how DNA methylation patterns are maintained. Nat. Rev. Genet. 2009, 10, 805-811.
    • (2009) Nat. Rev. Genet. , vol.10 , pp. 805-811
    • Jones, P.A.1    Liang, G.2
  • 21
    • 79952258043 scopus 로고    scopus 로고
    • Nucleosomes containing methylated DNA stabilize DNA methyltransferases 3A/3B and ensure faithful epigenetic inheritance
    • Sharma, S.; de Carvalho, D.D.; Jeong, S.; Jones, P.A.; Liang, G. Nucleosomes containing methylated DNA stabilize DNA methyltransferases 3A/3B and ensure faithful epigenetic inheritance. PLoS Genet. 2011, 7, e1001286.
    • (2011) PLoS Genet. , vol.7
    • Sharma, S.1    de Carvalho, D.D.2    Jeong, S.3    Jones, P.A.4    Liang, G.5
  • 23
    • 84913593548 scopus 로고    scopus 로고
    • Understanding the relationship between DNA and histone lysine methylation
    • Rose, N.R.; Klose, R.J. Understanding the relationship between DNA and histone lysine methylation. Biochim. Biophys. Acta 2014, doi: 10.1016/j.bbagrm.2014.02.007.
    • (2014) Biochim. Biophys. Acta
    • Rose, N.R.1    Klose, R.J.2
  • 25
    • 84861221693 scopus 로고    scopus 로고
    • Quantitative Sequencing of 5-methylcytosine and 5-hydroxymethylcytosine at single-base resolution
    • Booth, M.J.; Branco, M.R.; Ficz, G.; Oxley, D.; Krueger, F.; Reik, W.; Balasubramanian, S. Quantitative Sequencing of 5-methylcytosine and 5-hydroxymethylcytosine at single-base resolution. Science 2012, 336, 934-937.
    • (2012) Science , vol.336 , pp. 934-937
    • Booth, M.J.1    Branco, M.R.2    Ficz, G.3    Oxley, D.4    Krueger, F.5    Reik, W.6    Balasubramanian, S.7
  • 27
    • 79954457998 scopus 로고    scopus 로고
    • Genome-wide analysis of 5-hydroxymethylcytosine distribution reveals its dual function in transcriptional regulation in mouse embryonic stem cells
    • Wu, H.; D'Alessio, A.C.; Ito, S.; Wang, Z.; Cui, K.; Zhao, K.; Sun, Y.E.; Zhang, Y. Genome-wide analysis of 5-hydroxymethylcytosine distribution reveals its dual function in transcriptional regulation in mouse embryonic stem cells. Genes. Dev. 2011, 25, 679-684.
    • (2011) Genes. Dev. , vol.25 , pp. 679-684
    • Wu, H.1    D'Alessio, A.C.2    Ito, S.3    Wang, Z.4    Cui, K.5    Zhao, K.6    Sun, Y.E.7    Zhang, Y.8
  • 28
    • 79959209733 scopus 로고    scopus 로고
    • 5-Hydroxymethylcytosine is associated with enhancers and gene bodies in human embryonic stem cells
    • Stroud, H.; Feng, S.; Morey Kinney, S.; Pradhan, S.; Jacobsen, S.E. 5-Hydroxymethylcytosine is associated with enhancers and gene bodies in human embryonic stem cells. Genome Biol. 2011, 12, R54.
    • (2011) Genome Biol. , vol.12 , pp. R55
    • Stroud, H.1    Feng, S.2    Morey Kinney, S.3    Pradhan, S.4    Jacobsen, S.E.5
  • 29
    • 84860749868 scopus 로고    scopus 로고
    • Tet family proteins and 5-hydroxymethylcytosine in development and disease
    • Tan, L.; Shi, Y.G. Tet family proteins and 5-hydroxymethylcytosine in development and disease. Development 2012, 139, 1895-1902.
    • (2012) Development , vol.139 , pp. 1895-1902
    • Tan, L.1    Shi, Y.G.2
  • 30
    • 84891523954 scopus 로고    scopus 로고
    • PRDM14 promotes active DNA demethylation through the Ten-eleven translocation (TET)-mediated base excision repair pathway in embryonic stem cells
    • Okashita, N.; Kumaki, Y.; Ebi, K.; Nishi, M.; Okamoto, Y.; Nakayama, M.; Hashimoto, S.; Nakamura, T.; Sugasawa, K.; Kojima, N.; et al. PRDM14 promotes active DNA demethylation through the Ten-eleven translocation (TET)-mediated base excision repair pathway in embryonic stem cells. Development 2014, 141, 269-280.
    • (2014) Development , vol.141 , pp. 269-280
    • Okashita, N.1    Kumaki, Y.2    Ebi, K.3    Nishi, M.4    Okamoto, Y.5    Nakayama, M.6    Hashimoto, S.7    Nakamura, T.8    Sugasawa, K.9    Kojima, N.10
  • 31
    • 84888128463 scopus 로고    scopus 로고
    • DNA modifications repaired by base excision repair are epigenetic
    • Moore, S.P.; Toomire, K.J.; Strauss, P.R. DNA modifications repaired by base excision repair are epigenetic. DNA Repair (Amst.) 2013, 12, 1152-1158.
    • (2013) DNA Repair (Amst.) , vol.12 , pp. 1152-1158
    • Moore, S.P.1    Toomire, K.J.2    Strauss, P.R.3
  • 32
    • 84898678453 scopus 로고    scopus 로고
    • The Ten-Eleven Translocation-2 (TET2) gene in hematopoiesis and hematopoietic diseases
    • Solary, E.; Bernard, O.A.; Tefferi, A.; Fuks, F.; Vainchenker, W. The Ten-Eleven Translocation-2 (TET2) gene in hematopoiesis and hematopoietic diseases. Leukemia 2013, 2, 1-12.
    • (2013) Leukemia , vol.2 , pp. 1-12
    • Solary, E.1    Bernard, O.A.2    Tefferi, A.3    Fuks, F.4    Vainchenker, W.5
  • 34
    • 84877693964 scopus 로고    scopus 로고
    • Ascorbate induces ten-eleven translocation (Tet) methylcytosine dioxygenase-mediated generation of 5-hydroxymethylcytosine
    • Minor, E.A.; Court, B.L.; Young, J.I.; Wang, G. Ascorbate induces ten-eleven translocation (Tet) methylcytosine dioxygenase-mediated generation of 5-hydroxymethylcytosine. J. Biol. Chem. 2013, 288, 13669-13674.
    • (2013) J. Biol. Chem. , vol.288 , pp. 13669-13674
    • Minor, E.A.1    Court, B.L.2    Young, J.I.3    Wang, G.4
  • 36
    • 84871563384 scopus 로고    scopus 로고
    • MeCP2 binds to 5hmC enriched within active genes and accessible chromatin in the nervous system
    • Mellen, M.; Ayata, P.; Dewell, S.; Kriaucionis, S.; Heintz, N. MeCP2 binds to 5hmC enriched within active genes and accessible chromatin in the nervous system. Cell 2012, 151, 1417-1430.
    • (2012) Cell , vol.151 , pp. 1417-1430
    • Mellen, M.1    Ayata, P.2    Dewell, S.3    Kriaucionis, S.4    Heintz, N.5
  • 37
    • 84908277219 scopus 로고    scopus 로고
    • Breaking the Silence: The Interplay Between Transcription Factors and DNA Methylation
    • Dricu, P.A., Ed.; InTech: Rijeka, Croatia
    • Baron, B. Breaking the Silence: The Interplay Between Transcription Factors and DNA Methylation. In Methylation-From DNA, RNA and Histones to Diseases and Treatment; Dricu, P.A., Ed.; InTech: Rijeka, Croatia, 2012.
    • (2012) Methylation-From DNA, RNA and Histones to Diseases and Treatment
    • Baron, B.1
  • 39
    • 84876389811 scopus 로고    scopus 로고
    • Effects of DNA methylation on nucleosome stability
    • Collings, C.K.; Waddell, P.J.; Anderson, J.N. Effects of DNA methylation on nucleosome stability. Nucl. Acids Res. 2013, 41, 2918-2931.
    • (2013) Nucl. Acids Res. , vol.41 , pp. 2918-2931
    • Collings, C.K.1    Waddell, P.J.2    Anderson, J.N.3
  • 40
    • 84862908551 scopus 로고    scopus 로고
    • Effects of DNA methylation on the structure of nucleosomes
    • Lee, J.Y.; Lee, T.H. Effects of DNA methylation on the structure of nucleosomes. J. Am. Chem. Soc. 2012, 134, 173-175.
    • (2012) J. Am. Chem. Soc. , vol.134 , pp. 173-175
    • Lee, J.Y.1    Lee, T.H.2
  • 42
    • 77249178763 scopus 로고    scopus 로고
    • DNA methylation increases nucleosome compaction and rigidity
    • Choy, J.S.; Wei, S.; Lee, J.Y.; Tan, S.; Chu, S.; Lee, T.H. DNA methylation increases nucleosome compaction and rigidity. J. Am. Chem. Soc. 2010, 132, 1782-1783.
    • (2010) J. Am. Chem. Soc. , vol.132 , pp. 1782-1783
    • Choy, J.S.1    Wei, S.2    Lee, J.Y.3    Tan, S.4    Chu, S.5    Lee, T.H.6
  • 43
    • 84859261580 scopus 로고    scopus 로고
    • Gene reactivation by 5-aza-2_-deoxycytidine-induced demethylation requires SRCAP-mediated H2A.Z insertion to establish nucleosome depleted regions
    • Yang, X.; Noushmehr, H.; Han, H.; Andreu-Vieyra, C.; Liang, G.; Jones, P.A. Gene reactivation by 5-aza-2_-deoxycytidine-induced demethylation requires SRCAP-mediated H2A.Z insertion to establish nucleosome depleted regions. PLoS Genet. 2012, 8, e1002604.
    • (2012) PLoS Genet. , vol.8
    • Yang, X.1    Noushmehr, H.2    Han, H.3    Andreu-Vieyra, C.4    Liang, G.5    Jones, P.A.6
  • 44
    • 84858327532 scopus 로고    scopus 로고
    • Linking epigenetics to human disease and Rett syndrome: The emerging novel and challenging concepts in MeCP2 research
    • Zachariah, R.M.; Rastegar, M. Linking epigenetics to human disease and Rett syndrome: The emerging novel and challenging concepts in MeCP2 research. Neural Plast. 2012, 2012, 415825.
    • (2012) Neural Plast. , pp. 415825
    • Zachariah, R.M.1    Rastegar, M.2
  • 47
    • 84892954147 scopus 로고    scopus 로고
    • Increased binding of MeCP2 to the GAD1 and RELN promoters may be mediated by an enrichment of 5-hmC in autism spectrum disorder (ASD) cerebellum
    • Zhubi, A.; Chen, Y.; Dong, E.; Cook, E.H.; Guidotti, A.; Grayson, D.R. Increased binding of MeCP2 to the GAD1 and RELN promoters may be mediated by an enrichment of 5-hmC in autism spectrum disorder (ASD) cerebellum. Transl. Psychiatry 2014, 4, e349.
    • (2014) Transl. Psychiatry , vol.4
    • Zhubi, A.1    Chen, Y.2    Dong, E.3    Cook, E.H.4    Guidotti, A.5    Grayson, D.R.6
  • 48
    • 79955778919 scopus 로고    scopus 로고
    • Human epigenome data reveal increased CpG methylation in alternatively spliced sites and putative exonic splicing enhancers
    • Anastasiadou, C.; Malousi, A.; Maglaveras, N.; Kouidou, S. Human epigenome data reveal increased CpG methylation in alternatively spliced sites and putative exonic splicing enhancers. DNA Cell Biol. 2011, 30, 267-275.
    • (2011) DNA Cell Biol. , vol.30 , pp. 267-275
    • Anastasiadou, C.1    Malousi, A.2    Maglaveras, N.3    Kouidou, S.4
  • 49
    • 77954171220 scopus 로고    scopus 로고
    • Contrasting chromatin organization of CpG islands and exons in the human genome
    • Choi, J.K. Contrasting chromatin organization of CpG islands and exons in the human genome. Genome Biol. 2010, 11, R70.
    • (2010) Genome Biol. , vol.11 , pp. R70
    • Choi, J.K.1
  • 50
    • 84864689380 scopus 로고    scopus 로고
    • DNA hypermethylation of alternatively spliced and repeat sequences in humans
    • Malousi, A.; Kouidou, S. DNA hypermethylation of alternatively spliced and repeat sequences in humans. Mol. Genet. Genomics 2012, 287, 631-642.
    • (2012) Mol. Genet. Genomics , vol.287 , pp. 631-642
    • Malousi, A.1    Kouidou, S.2
  • 51
    • 84887214395 scopus 로고    scopus 로고
    • Intragenic DNA methylation modulates alternative splicing by recruiting MeCP2 to promote exon recognition
    • Maunakea, A.K.; Chepelev, I.; Cui, K.; Zhao, K. Intragenic DNA methylation modulates alternative splicing by recruiting MeCP2 to promote exon recognition. Cell Res. 2013, 23, 1256-1269.
    • (2013) Cell Res. , vol.23 , pp. 1256-1269
    • Maunakea, A.K.1    Chepelev, I.2    Cui, K.3    Zhao, K.4
  • 52
    • 79960724914 scopus 로고    scopus 로고
    • A brain-derived MeCP2 complex supports a role for MeCP2 in RNA processing
    • Long, S.W.; Ooi, J.Y.; Yau, P.M.; Jones, P.L. A brain-derived MeCP2 complex supports a role for MeCP2 in RNA processing. Biosci. Rep. 2011, 31, 333-343.
    • (2011) Biosci. Rep. , vol.31 , pp. 333-343
    • Long, S.W.1    Ooi, J.Y.2    Yau, P.M.3    Jones, P.L.4
  • 54
    • 84857785578 scopus 로고    scopus 로고
    • CTCF: From insulators to alternative splicing regulation
    • Kornblihtt, A.R. CTCF: From insulators to alternative splicing regulation. Cell Res. 2012, 22, 450-452.
    • (2012) Cell Res. , vol.22 , pp. 450-452
    • Kornblihtt, A.R.1
  • 57
    • 84878891601 scopus 로고    scopus 로고
    • Promoter-proximal CCCTC-factor binding is associated with an increase in the transcriptional pausing index
    • Paredes, S.H.; Melgar, M.F.; Sethupathy, P. Promoter-proximal CCCTC-factor binding is associated with an increase in the transcriptional pausing index. Bioinformatics 2013, 29, 1485-1487.
    • (2013) Bioinformatics , vol.29 , pp. 1485-1487
    • Paredes, S.H.1    Melgar, M.F.2    Sethupathy, P.3
  • 58
    • 84875878011 scopus 로고    scopus 로고
    • Chromosome-wide regulation of euchromatin-specific 5mC to 5hmC conversion in mouse ES cells and female human somatic cells
    • Kubiura, M.; Okano, M.; Kimura, H.; Kawamura, F.; Tada, M. Chromosome-wide regulation of euchromatin-specific 5mC to 5hmC conversion in mouse ES cells and female human somatic cells. Chromosom. Res. 2012, 20, 837-848.
    • (2012) Chromosom. Res. , vol.20 , pp. 837-848
    • Kubiura, M.1    Okano, M.2    Kimura, H.3    Kawamura, F.4    Tada, M.5
  • 59
    • 84872455562 scopus 로고    scopus 로고
    • 5-Carboxylcytosine is localized to euchromatic regions in the nuclei of follicular cells in axolotl ovary
    • Alioui, A.; Wheldon, L.M.; Abakir, A.; Ferjentsik, Z.; Johnson, A.D.; Ruzov, A. 5-Carboxylcytosine is localized to euchromatic regions in the nuclei of follicular cells in axolotl ovary. Nucleus 2012, 3, 565-569.
    • (2012) Nucleus , vol.3 , pp. 565-569
    • Alioui, A.1    Wheldon, L.M.2    Abakir, A.3    Ferjentsik, Z.4    Johnson, A.D.5    Ruzov, A.6
  • 60
    • 84876946045 scopus 로고    scopus 로고
    • Genome-wide analysis reveals TET- and TDG-dependent 5-methylcytosine oxidation dynamics
    • Shen, L.; Wu, H.; Diep, D.; Yamaguchi, S.; D'Alessio, A.C.; Fung, H.L.; Zhang, K.; Zhang, Y. Genome-wide analysis reveals TET- and TDG-dependent 5-methylcytosine oxidation dynamics. Cell 2013, 153, 692-706.
    • (2013) Cell , vol.153 , pp. 692-706
    • Shen, L.1    Wu, H.2    Diep, D.3    Yamaguchi, S.4    D'Alessio, A.C.5    Fung, H.L.6    Zhang, K.7    Zhang, Y.8
  • 62
    • 77956683757 scopus 로고    scopus 로고
    • MeCP2 binds cooperatively to its substrate and competes with histone H1 for chromatin binding sites
    • Ghosh, R.P.; Horowitz-Scherer, R.A.; Nikitina, T.; Shlyakhtenko, L.S.; Woodcock, C.L. MeCP2 binds cooperatively to its substrate and competes with histone H1 for chromatin binding sites. Mol. Cell. Biol. 2010, 30, 4656-4670.
    • (2010) Mol. Cell. Biol. , vol.30 , pp. 4656-4670
    • Ghosh, R.P.1    Horowitz-Scherer, R.A.2    Nikitina, T.3    Shlyakhtenko, L.S.4    Woodcock, C.L.5
  • 63
    • 34948908780 scopus 로고    scopus 로고
    • MeCP2-chromatin interactions include the formation of chromatosome-like structures and are altered in mutations causing Rett syndrome
    • Nikitina, T.; Ghosh, R.P.; Horowitz-Scherer, R.A.; Hansen, J.C.; Grigoryev, S.A.; Woodcock, C.L. MeCP2-chromatin interactions include the formation of chromatosome-like structures and are altered in mutations causing Rett syndrome. J. Biol. Chem. 2007, 282, 28237-28245.
    • (2007) J. Biol. Chem. , vol.282 , pp. 28237-28245
    • Nikitina, T.1    Ghosh, R.P.2    Horowitz-Scherer, R.A.3    Hansen, J.C.4    Grigoryev, S.A.5    Woodcock, C.L.6
  • 66
    • 67549119096 scopus 로고    scopus 로고
    • CTCF: Master weaver of the genome
    • Phillips, J.E.; Corces, V.G. CTCF: Master weaver of the genome. Cell 2009, 137, 1194-1211.
    • (2009) Cell , vol.137 , pp. 1194-1211
    • Phillips, J.E.1    Corces, V.G.2
  • 67
    • 42249105007 scopus 로고    scopus 로고
    • The insulator factor CTCF controls MHC class II gene expression and is required for the formation of long-distance chromatin interactions
    • Majumder, P.; Gomez, J.A.; Chadwick, B.P.; Boss, J.M. The insulator factor CTCF controls MHC class II gene expression and is required for the formation of long-distance chromatin interactions. J. Exp. Med. 2008, 205, 785-798.
    • (2008) J. Exp. Med. , vol.205 , pp. 785-798
    • Majumder, P.1    Gomez, J.A.2    Chadwick, B.P.3    Boss, J.M.4
  • 68
    • 84891476248 scopus 로고    scopus 로고
    • CTCF: The protein, the binding partners, the binding sites and their chromatin loops
    • Holwerda, S.J.; de Laat, W. CTCF: The protein, the binding partners, the binding sites and their chromatin loops. Philos. Trans. R Soc. Lond. B Biol. Sci. 2013, 368, 20120369.
    • (2013) Philos. Trans. R Soc. Lond. B Biol. Sci. , vol.368 , pp. 20120369
    • Holwerda, S.J.1    de Laat, W.2
  • 70
    • 78049519411 scopus 로고    scopus 로고
    • Intra- and inter-chromosomal interactions correlate with CTCF binding genome wide
    • Botta, M.; Haider, S.; Leung, I.X.; Lio, P.; Mozziconacci, J. Intra- and inter-chromosomal interactions correlate with CTCF binding genome wide. Mol. Syst. Biol. 2010, 6, 426.
    • (2010) Mol. Syst. Biol. , vol.6 , pp. 426
    • Botta, M.1    Haider, S.2    Leung, I.X.3    Lio, P.4    Mozziconacci, J.5
  • 71
    • 34248223080 scopus 로고    scopus 로고
    • DNA methylation affects nuclear organization, histone modifications, and linker histone binding but not chromatin compaction
    • Gilbert, N.; Thomson, I.; Boyle, S.; Allan, J.; Ramsahoye, B.; Bickmore, W.A. DNA methylation affects nuclear organization, histone modifications, and linker histone binding but not chromatin compaction. J. Cell Biol. 2007, 177, 401-411.
    • (2007) J. Cell Biol. , vol.177 , pp. 401-411
    • Gilbert, N.1    Thomson, I.2    Boyle, S.3    Allan, J.4    Ramsahoye, B.5    Bickmore, W.A.6
  • 73
    • 36749083424 scopus 로고    scopus 로고
    • Chromosome territory reorganization in a human disease with altered DNA methylation
    • Matarazzo, M.R.; Boyle, S.; D'Esposito, M.; Bickmore, W.A. Chromosome territory reorganization in a human disease with altered DNA methylation. Proc. Natl. Acad. Sci. USA 2007, 104, 16546-16551.
    • (2007) Proc. Natl. Acad. Sci. USA , vol.104 , pp. 16546-16551
    • Matarazzo, M.R.1    Boyle, S.2    D'Esposito, M.3    Bickmore, W.A.4
  • 76
    • 0035837378 scopus 로고    scopus 로고
    • Mobilization of transposons by a mutation abolishing full DNA methylation in Arabidopsis
    • Miura, A.; Yonebayashi, S.; Watanabe, K.; Toyama, T.; Shimada, H.; Kakutani, T. Mobilization of transposons by a mutation abolishing full DNA methylation in Arabidopsis. Nature 2001, 411, 212-214.
    • (2001) Nature , vol.411 , pp. 212-214
    • Miura, A.1    Yonebayashi, S.2    Watanabe, K.3    Toyama, T.4    Shimada, H.5    Kakutani, T.6
  • 77
    • 33947303168 scopus 로고    scopus 로고
    • Transposable elements and the epigenetic regulation of the genome
    • Slotkin, R.K.; Martienssen, R. Transposable elements and the epigenetic regulation of the genome. Nat. Rev. Genet. 2007, 8, 272-285.
    • (2007) Nat. Rev. Genet. , vol.8 , pp. 272-285
    • Slotkin, R.K.1    Martienssen, R.2
  • 79
    • 0036333598 scopus 로고    scopus 로고
    • Erasing genomic imprinting memory in mouse clone embryos produced from day 11.5 primordial germ cells
    • Lee, J.; Inoue, K.; Ono, R.; Ogonuki, N.; Kohda, T.; Kaneko-Ishino, T.; Ogura, A.; Ishino, F. Erasing genomic imprinting memory in mouse clone embryos produced from day 11.5 primordial germ cells. Development 2002, 129, 1807-1817.
    • (2002) Development , vol.129 , pp. 1807-1817
    • Lee, J.1    Inoue, K.2    Ono, R.3    Ogonuki, N.4    Kohda, T.5    Kaneko-Ishino, T.6    Ogura, A.7    Ishino, F.8
  • 80
    • 84874655393 scopus 로고    scopus 로고
    • Dynamics of 5-methylcytosine and 5-hydroxymethylcytosine during germ cell reprogramming
    • Yamaguchi, S.; Hong, K.; Liu, R.; Inoue, A.; Shen, L.; Zhang, K.; Zhang, Y. Dynamics of 5-methylcytosine and 5-hydroxymethylcytosine during germ cell reprogramming. Cell Res. 2013, 23, 329-339.
    • (2013) Cell Res. , vol.23 , pp. 329-339
    • Yamaguchi, S.1    Hong, K.2    Liu, R.3    Inoue, A.4    Shen, L.5    Zhang, K.6    Zhang, Y.7
  • 81
    • 84872770694 scopus 로고    scopus 로고
    • Germline DNA demethylation dynamics and imprint erasure through 5-hydroxymethylcytosine
    • Hackett, J.A.; Sengupta, R.; Zylicz, J.J.; Murakami, K.; Lee, C.; Down, T.A.; Surani, M.A. Germline DNA demethylation dynamics and imprint erasure through 5-hydroxymethylcytosine. Science 2013, 339, 448-452.
    • (2013) Science , vol.339 , pp. 448-452
    • Hackett, J.A.1    Sengupta, R.2    Zylicz, J.J.3    Murakami, K.4    Lee, C.5    Down, T.A.6    Surani, M.A.7
  • 82
    • 84863752367 scopus 로고    scopus 로고
    • Differentially methylated regions of imprinted genes in prenatal, perinatal and postnatal human tissues
    • Murphy, S.K.; Huang, Z.; Hoyo, C. Differentially methylated regions of imprinted genes in prenatal, perinatal and postnatal human tissues. PLoS One 2012, 7, e40924.
    • (2012) PLoS One , vol.7
    • Murphy, S.K.1    Huang, Z.2    Hoyo, C.3
  • 83
    • 80053449066 scopus 로고    scopus 로고
    • Impact of the genome on the epigenome is manifested in DNA methylation patterns of imprinted regions in monozygotic and dizygotic twins
    • Coolen, M.W.; Statham, A.L.; Qu, W.; Campbell, M.J.; Henders, A.K.; Montgomery, G.W.; Martin, N.G.; Clark, S.J. Impact of the genome on the epigenome is manifested in DNA methylation patterns of imprinted regions in monozygotic and dizygotic twins. PLoS One 2011, 6, e25590.
    • (2011) PLoS One , vol.6
    • Coolen, M.W.1    Statham, A.L.2    Qu, W.3    Campbell, M.J.4    Henders, A.K.5    Montgomery, G.W.6    Martin, N.G.7    Clark, S.J.8
  • 84
    • 78650495163 scopus 로고    scopus 로고
    • Genetic and epigenetic dysregulation of imprinted genes in the brain
    • Kernohan, K.D.; Bérubé, N.G. Genetic and epigenetic dysregulation of imprinted genes in the brain. Epigenomics 2010, 2, 743-763.
    • (2010) Epigenomics , vol.2 , pp. 743-763
    • Kernohan, K.D.1    Bérubé, N.G.2
  • 87
    • 34249711442 scopus 로고    scopus 로고
    • The Odyssey of MeCP2 and parental imprinting
    • LaSalle, J.M. The Odyssey of MeCP2 and parental imprinting. Epigenetics 2007, 2, 5-10.
    • (2007) Epigenetics , vol.2 , pp. 5-10
    • LaSalle, J.M.1
  • 89
    • 1842715884 scopus 로고    scopus 로고
    • Genomic imprinting: CTCF protects the boundaries
    • Lewis, A.; Murrell, A. Genomic imprinting: CTCF protects the boundaries. Curr. Biol. 2004, 14, R284-R286.
    • (2004) Curr. Biol. , vol.14 , pp. R284-R286
    • Lewis, A.1    Murrell, A.2
  • 90
    • 84885060271 scopus 로고    scopus 로고
    • Genome-wide and parental allele-specific analysis of CTCF and cohesin DNA binding in mouse brain reveals a tissue-specific binding pattern and an association with imprinted differentially methylated regions
    • Prickett, A.R.; Barkas, N.; McCole, R.B.; Hughes, S.; Amante, S.M.; Schulz, R.; Oakey, R.J. Genome-wide and parental allele-specific analysis of CTCF and cohesin DNA binding in mouse brain reveals a tissue-specific binding pattern and an association with imprinted differentially methylated regions. Genome Res. 2013, 23, 1624-1635.
    • (2013) Genome Res. , vol.23 , pp. 1624-1635
    • Prickett, A.R.1    Barkas, N.2    McCole, R.B.3    Hughes, S.4    Amante, S.M.5    Schulz, R.6    Oakey, R.J.7
  • 91
    • 84862908822 scopus 로고    scopus 로고
    • Zinc finger protein ZFP57 requires its co-factor to recruit DNA methyltransferases and maintains DNA methylation imprint in embryonic stem cells via its transcriptional repression domain
    • Zuo, X.; Sheng, J.; Lau, H.-T.; McDonald, C.M.; Andrade, M.; Cullen, D.E.; Bell, F.T.; Iacovino, M.; Kyba, M.; Xu, G.; et al. Zinc finger protein ZFP57 requires its co-factor to recruit DNA methyltransferases and maintains DNA methylation imprint in embryonic stem cells via its transcriptional repression domain. J. Biol. Chem. 2012, 287, 2107-2118.
    • (2012) J. Biol. Chem. , vol.287 , pp. 2107-2118
    • Zuo, X.1    Sheng, J.2    Lau, H.-T.3    McDonald, C.M.4    Andrade, M.5    Cullen, D.E.6    Bell, F.T.7    Iacovino, M.8    Kyba, M.9    Xu, G.10
  • 92
    • 80555156105 scopus 로고    scopus 로고
    • In embryonic stem cells, ZFP57/KAP1 recognize a methylated hexanucleotide to affect chromatin and DNA methylation of imprinting control regions
    • Quenneville, S.; Verde, G.; Corsinotti, A.; Kapopoulou, A.; Jakobsson, J.; Offner, S.; Baglivo, I.; Pedone, P.V.; Grimaldi, G.; Riccio, A.; et al. In embryonic stem cells, ZFP57/KAP1 recognize a methylated hexanucleotide to affect chromatin and DNA methylation of imprinting control regions. Mol. Cell 2011, 44, 361-372.
    • (2011) Mol. Cell , vol.44 , pp. 361-372
    • Quenneville, S.1    Verde, G.2    Corsinotti, A.3    Kapopoulou, A.4    Jakobsson, J.5    Offner, S.6    Baglivo, I.7    Pedone, P.V.8    Grimaldi, G.9    Riccio, A.10
  • 93
    • 79961028059 scopus 로고    scopus 로고
    • Xist regulation and function explored
    • Pontier, D.B.; Gribnau, J. Xist regulation and function explored. Hum. Genet. 2011, 130, 223-236.
    • (2011) Hum. Genet. , vol.130 , pp. 223-236
    • Pontier, D.B.1    Gribnau, J.2
  • 95
    • 84904126142 scopus 로고    scopus 로고
    • X chromosome: X inactivation
    • Ahn, J.Y.; Lee, J.T. X chromosome: X inactivation. Nat. Educ. 2008, 1, 24.
    • (2008) Nat. Educ. , vol.1 , pp. 24
    • Ahn, J.Y.1    Lee, J.T.2
  • 96
    • 79961090805 scopus 로고    scopus 로고
    • Evolutionary diversity and developmental regulation of X-chromosome inactivation
    • Escamilla-Del-Arenal, M.; da Rocha, S.T.; Heard, E. Evolutionary diversity and developmental regulation of X-chromosome inactivation. Hum. Genet. 2011, 130, 307-327.
    • (2011) Hum. Genet. , vol.130 , pp. 307-327
    • Escamilla-Del-Arenal, M.1    da Rocha, S.T.2    Heard, E.3
  • 98
    • 33847304609 scopus 로고    scopus 로고
    • Gene body-specific methylation on the active X chromosome
    • Hellman, A.; Chess, A. Gene body-specific methylation on the active X chromosome. Science 2007, 315, 1141-1143.
    • (2007) Science , vol.315 , pp. 1141-1143
    • Hellman, A.1    Chess, A.2
  • 99
    • 0034757204 scopus 로고    scopus 로고
    • Identification of TSIX, encoding an RNA antisense to human XIST, reveals differences from its murine counterpart: Implications for X inactivation
    • Migeon, B.R.; Chowdhury, A.K.; Dunston, J.A.; McIntosh, I. Identification of TSIX, encoding an RNA antisense to human XIST, reveals differences from its murine counterpart: Implications for X inactivation. Am. J. Hum. Genet. 2001, 69, 951-960.
    • (2001) Am. J. Hum. Genet. , vol.69 , pp. 951-960
    • Migeon, B.R.1    Chowdhury, A.K.2    Dunston, J.A.3    McIntosh, I.4
  • 101
    • 84861883921 scopus 로고    scopus 로고
    • Sequential ChIP-bisulfite sequencing enables direct genome-scale investigation of chromatin and DNA methylation cross-talk
    • Brinkman, A.B.; Gu, H.; Bartels, S.J.; Zhang, Y.; Matarese, F.; Simmer, F.; Marks, H.; Bock, C.; Gnirke, A.; Meissner, A.; et al. Sequential ChIP-bisulfite sequencing enables direct genome-scale investigation of chromatin and DNA methylation cross-talk. Genome Res. 2012, 22, 1128-1138.
    • (2012) Genome Res. , vol.22 , pp. 1128-1138
    • Brinkman, A.B.1    Gu, H.2    Bartels, S.J.3    Zhang, Y.4    Matarese, F.5    Simmer, F.6    Marks, H.7    Bock, C.8    Gnirke, A.9    Meissner, A.10
  • 103
    • 22344451854 scopus 로고    scopus 로고
    • Tsix transcription across the Xist gene alters chromatin conformation without affecting Xist transcription: Implications for X-chromosome inactivation
    • Navarro, P.; Pichard, S.; Ciaudo, C.; Avner, P.; Rougeulle, C. Tsix transcription across the Xist gene alters chromatin conformation without affecting Xist transcription: Implications for X-chromosome inactivation. Genes Dev. 2005, 19, 1474-1484.
    • (2005) Genes Dev. , vol.19 , pp. 1474-1484
    • Navarro, P.1    Pichard, S.2    Ciaudo, C.3    Avner, P.4    Rougeulle, C.5
  • 104
    • 0037059554 scopus 로고    scopus 로고
    • CTCF, a candidate trans-acting factor for X-inactivation choice
    • Chao, W.; Huynh, K.D.; Spencer, R.J.; Davidow, L.S.; Lee, J.T. CTCF, a candidate trans-acting factor for X-inactivation choice. Science 2002, 295, 345-347.
    • (2002) Science , vol.295 , pp. 345-347
    • Chao, W.1    Huynh, K.D.2    Spencer, R.J.3    Davidow, L.S.4    Lee, J.T.5
  • 105
    • 84908284456 scopus 로고    scopus 로고
    • Epigenetic re-programming during mammalian preimplantation embryogenesis and pgc development
    • Zhou, Q.; Teng, F. Epigenetic re-programming during mammalian preimplantation embryogenesis and pgc development. J. IVF Reprod Med. Genet. 2013, 1, 114.
    • (2013) J. IVF Reprod Med. Genet. , vol.1 , pp. 114
    • Zhou, Q.1    Teng, F.2
  • 106
    • 77950586365 scopus 로고    scopus 로고
    • DNA methyltransferases and methyl-binding proteins of mammals
    • Lan, J.; Hua, S.; He, X.; Zhang, Y. DNA methyltransferases and methyl-binding proteins of mammals. Acta Biochim. Biophys. Sin. 2010, 42, 243-252.
    • (2010) Acta Biochim. Biophys. Sin. , vol.42 , pp. 243-252
    • Lan, J.1    Hua, S.2    He, X.3    Zhang, Y.4
  • 107
    • 0037144441 scopus 로고    scopus 로고
    • The mCpG-binding domain of human MBD3 does not bind to mCpG but interacts with NuRD/Mi2 components HDAC1 and MTA2
    • Saito, M.; Ishikawa, F. The mCpG-binding domain of human MBD3 does not bind to mCpG but interacts with NuRD/Mi2 components HDAC1 and MTA2. J. Biol. Chem. 2002, 277, 35434-35439.
    • (2002) J. Biol. Chem. , vol.277 , pp. 35434-35439
    • Saito, M.1    Ishikawa, F.2
  • 110
    • 0037444026 scopus 로고    scopus 로고
    • The affinity of different MBD proteins for a specific methylated locus depends on their intrinsic binding properties
    • Fraga, M.F.; Ballestar, E.; Montoya, G.; Taysavang, P.; Wade, P.A.; Esteller, M. The affinity of different MBD proteins for a specific methylated locus depends on their intrinsic binding properties. Nucl. Acids Res. 2003, 31, 1765-1774.
    • (2003) Nucl. Acids Res. , vol.31 , pp. 1765-1774
    • Fraga, M.F.1    Ballestar, E.2    Montoya, G.3    Taysavang, P.4    Wade, P.A.5    Esteller, M.6
  • 111
    • 24044523177 scopus 로고    scopus 로고
    • DNA binding selectivity of MeCP2 due to a requirement for A/T sequences adjacent to methyl-CpG
    • Klose, R.J.; Sarraf, S.A.; Schmiedeberg, L.; McDermott, S.M.; Stancheva, I.; Bird, A.P. DNA binding selectivity of MeCP2 due to a requirement for A/T sequences adjacent to methyl-CpG. Mol. Cell 2005, 19, 667-678.
    • (2005) Mol. Cell , vol.19 , pp. 667-678
    • Klose, R.J.1    Sarraf, S.A.2    Schmiedeberg, L.3    McDermott, S.M.4    Stancheva, I.5    Bird, A.P.6
  • 112
    • 77955838329 scopus 로고    scopus 로고
    • Recruitment of MBD1 to target genes requires sequence-specific interaction of the MBD domain with methylated DNA
    • Clouaire, T.; de Las Heras, J.I.; Merusi, C.; Stancheva, I. Recruitment of MBD1 to target genes requires sequence-specific interaction of the MBD domain with methylated DNA. Nucl. Acids Res. 2010, 38, 4620-4634.
    • (2010) Nucl. Acids Res. , vol.38 , pp. 4620-4634
    • Clouaire, T.1    de Las Heras, J.I.2    Merusi, C.3    Stancheva, I.4
  • 113
    • 80052016907 scopus 로고    scopus 로고
    • Solution structure and dynamic analysis of chicken MBD2 methyl binding domain bound to a target-methylated DNA sequence
    • Scarsdale, J.N.; Webb, H.D.; Ginder, G.D.; Williams, D.C., Jr. Solution structure and dynamic analysis of chicken MBD2 methyl binding domain bound to a target-methylated DNA sequence. Nucl. Acids Res. 2011, 39, 6741-6752.
    • (2011) Nucl. Acids Res. , vol.39 , pp. 6741-6752
    • Scarsdale, J.N.1    Webb, H.D.2    Ginder, G.D.3    Williams, D.C.4
  • 115
    • 84886035297 scopus 로고    scopus 로고
    • A screen for hydroxymethylcytosine and formylcytosine binding proteins suggests functions in transcription and chromatin regulation
    • Iurlaro, M.; Ficz, G.; Oxley, D.; Raiber, E.A.; Bachman, M.; Booth, M.J.; Andrews, S.; Balasubramanian, S.; Reik, W. A screen for hydroxymethylcytosine and formylcytosine binding proteins suggests functions in transcription and chromatin regulation. Genome Biol 2013, 14, R119.
    • (2013) Genome Biol , vol.14 , pp. R119
    • Iurlaro, M.1    Ficz, G.2    Oxley, D.3    Raiber, E.A.4    Bachman, M.5    Booth, M.J.6    Andrews, S.7    Balasubramanian, S.8    Reik, W.9
  • 116
    • 84455167621 scopus 로고    scopus 로고
    • Mbd3/NURD complex regulates expression of 5-hydroxymethylcytosine marked genes in embryonic stem cells
    • Yildirim, O.; Li, R.; Hung, J.H.; Chen, P.B.; Dong, X.; Ee, L.S.; Weng, Z.; Rando, O.J.; Fazzio, T.G. Mbd3/NURD complex regulates expression of 5-hydroxymethylcytosine marked genes in embryonic stem cells. Cell 2011, 147, 1498-1510.
    • (2011) Cell , vol.147 , pp. 1498-1510
    • Yildirim, O.1    Li, R.2    Hung, J.H.3    Chen, P.B.4    Dong, X.5    Ee, L.S.6    Weng, Z.7    Rando, O.J.8    Fazzio, T.G.9
  • 117
    • 84876278080 scopus 로고    scopus 로고
    • Methylation-dependent and -independent genomic targeting principles of the MBD protein family
    • Baubec, T.; Ivanek, R.; Lienert, F.; Schubeler, D. Methylation-dependent and -independent genomic targeting principles of the MBD protein family. Cell 2013, 153, 480-492.
    • (2013) Cell , vol.153 , pp. 480-492
    • Baubec, T.1    Ivanek, R.2    Lienert, F.3    Schubeler, D.4
  • 118
    • 79951962788 scopus 로고    scopus 로고
    • Binding of the Rett syndrome protein, MeCP2, to methylated and unmethylated DNA and chromatin
    • Hansen, J.C.; Ghosh, R.P.; Woodcock, C.L. Binding of the Rett syndrome protein, MeCP2, to methylated and unmethylated DNA and chromatin. IUBMB Life 2010, 62, 732-738.
    • (2010) IUBMB Life , vol.62 , pp. 732-738
    • Hansen, J.C.1    Ghosh, R.P.2    Woodcock, C.L.3
  • 120
    • 1842505317 scopus 로고    scopus 로고
    • Mbd1 is recruited to both methylated and nonmethylated CpGs via distinct DNA binding domains
    • Jorgensen, H.F.; Ben-Porath, I.; Bird, A.P. Mbd1 is recruited to both methylated and nonmethylated CpGs via distinct DNA binding domains. Mol. Cell. Biol. 2004, 24, 3387-3395.
    • (2004) Mol. Cell. Biol. , vol.24 , pp. 3387-3395
    • Jorgensen, H.F.1    Ben-Porath, I.2    Bird, A.P.3
  • 122
    • 80054790280 scopus 로고    scopus 로고
    • The Roles of the Methyl-CpG Binding Proteins in Cancer
    • Parry, L.; Clarke, A.R. The Roles of the Methyl-CpG Binding Proteins in Cancer. Genes Cancer 2011, 2, 618-630.
    • (2011) Genes Cancer , vol.2 , pp. 618-630
    • Parry, L.1    Clarke, A.R.2
  • 123
    • 0038136913 scopus 로고    scopus 로고
    • Methyl-CpG-binding protein, MeCP2, is a target molecule for maintenance DNA methyltransferase, Dnmt1
    • Kimura, H.; Shiota, K. Methyl-CpG-binding protein, MeCP2, is a target molecule for maintenance DNA methyltransferase, Dnmt1. J. Biol. Chem. 2003, 278, 4806-4812.
    • (2003) J. Biol. Chem. , vol.278 , pp. 4806-4812
    • Kimura, H.1    Shiota, K.2
  • 124
    • 84897139220 scopus 로고    scopus 로고
    • Transgenerational epigenetic inheritance: Myths and mechanisms
    • Heard, E.; Martienssen, R.A. Transgenerational epigenetic inheritance: Myths and mechanisms. Cell 2014, 157, 95-109.
    • (2014) Cell , vol.157 , pp. 95-109
    • Heard, E.1    Martienssen, R.A.2
  • 125
    • 84876458561 scopus 로고    scopus 로고
    • Identification of CpG-SNPs associated with type 2 diabetes and differential DNA methylation in human pancreatic islets
    • Dayeh, T.A.; Olsson, A.H.; Volkov, P.; Almgren, P.; Ronn, T.; Ling, C. Identification of CpG-SNPs associated with type 2 diabetes and differential DNA methylation in human pancreatic islets. Diabetologia 2013, 56, 1036-1046.
    • (2013) Diabetologia , vol.56 , pp. 1036-1046
    • Dayeh, T.A.1    Olsson, A.H.2    Volkov, P.3    Almgren, P.4    Ronn, T.5    Ling, C.6
  • 127
    • 80053897690 scopus 로고    scopus 로고
    • Role of epigenetics in cancer initiation and progression
    • Chik, F.; Szyf, M.; Rabbani, S.A. Role of epigenetics in cancer initiation and progression. Adv. Exp. Med. Biol. 2011, 720, 91-104.
    • (2011) Adv. Exp. Med. Biol. , vol.720 , pp. 91-104
    • Chik, F.1    Szyf, M.2    Rabbani, S.A.3
  • 128
    • 60249094056 scopus 로고    scopus 로고
    • Silencing of MBD1 and MeCP2 in prostate-cancer-derived PC3 cells produces differential gene expression profiles and cellular phenotypes
    • Yaqinuddin, A.; Abbas, F.; Naqvi, S.Z.; Bashir, M.U.; Qazi, R.; Qureshi, S.A. Silencing of MBD1 and MeCP2 in prostate-cancer-derived PC3 cells produces differential gene expression profiles and cellular phenotypes. Biosci. Rep. 2008, 28, 319-326.
    • (2008) Biosci. Rep. , vol.28 , pp. 319-326
    • Yaqinuddin, A.1    Abbas, F.2    Naqvi, S.Z.3    Bashir, M.U.4    Qazi, R.5    Qureshi, S.A.6
  • 129
    • 84864301890 scopus 로고    scopus 로고
    • The role of methyl-binding proteins in chromatin organization and epigenome maintenance
    • Fournier, A.; Sasai, N.; Nakao, M.; Defossez, P.A. The role of methyl-binding proteins in chromatin organization and epigenome maintenance. Br. Funct. Genomics. 2012, 11, 251-264.
    • (2012) Br. Funct. Genomics. , vol.11 , pp. 251-264
    • Fournier, A.1    Sasai, N.2    Nakao, M.3    Defossez, P.A.4
  • 130
    • 33751571420 scopus 로고    scopus 로고
    • SPAN-XB core promoter sequence is regulated in myeloma cells by specific CpG dinucleotides associated with the MeCP2 protein
    • Wang, Z.; Zhang, J.; Zhang, Y.; Srivenugopal, K.S.; Lim, S.H. SPAN-XB core promoter sequence is regulated in myeloma cells by specific CpG dinucleotides associated with the MeCP2 protein. Int. J. Cancer 2006, 119, 2878-2884.
    • (2006) Int. J. Cancer , vol.119 , pp. 2878-2884
    • Wang, Z.1    Zhang, J.2    Zhang, Y.3    Srivenugopal, K.S.4    Lim, S.H.5
  • 132
    • 84861190762 scopus 로고    scopus 로고
    • A two-stage association study identifies methyl-CpG-binding domain protein 2 gene polymorphisms as candidates for breast cancer susceptibility
    • Sapkota, Y.; Robson, P.; Lai, R.; Cass, C.E.; Mackey, J.R.; Damaraju, S. A two-stage association study identifies methyl-CpG-binding domain protein 2 gene polymorphisms as candidates for breast cancer susceptibility. Eur. J. Hum. Genet. 2012, 20, 682-689.
    • (2012) Eur. J. Hum. Genet. , vol.20 , pp. 682-689
    • Sapkota, Y.1    Robson, P.2    Lai, R.3    Cass, C.E.4    McKey, J.R.5    Damaraju, S.6
  • 133
    • 84889077185 scopus 로고    scopus 로고
    • Transcription onset of genes critical in liver carcinogenesis is epigenetically regulated by methylated DNA-binding protein MBD2
    • Stefanska, B.; Suderman, M.; Machnes, Z.; Bhattacharyya, B.; Hallett, M.; Szyf, M. Transcription onset of genes critical in liver carcinogenesis is epigenetically regulated by methylated DNA-binding protein MBD2. Carcinogenesis 2013, 34, 2738-2749.
    • (2013) Carcinogenesis , vol.34 , pp. 2738-2749
    • Stefanska, B.1    Suderman, M.2    McHnes, Z.3    Bhattacharyya, B.4    Hallett, M.5    Szyf, M.6
  • 135
    • 0035868824 scopus 로고    scopus 로고
    • Closely related proteins MBD2 and MBD3 play distinctive but interacting roles in mouse development
    • Hendrich, B.; Guy, J.; Ramsahoye, B.; Wilson, V.A.; Bird, A. Closely related proteins MBD2 and MBD3 play distinctive but interacting roles in mouse development. Genes Dev. 2001, 15, 710-723.
    • (2001) Genes Dev. , vol.15 , pp. 710-723
    • Hendrich, B.1    Guy, J.2    Ramsahoye, B.3    Wilson, V.A.4    Bird, A.5
  • 137
    • 84872355378 scopus 로고    scopus 로고
    • The MBD4 Glu346Lys polymorphism is associated with the risk of cervical cancer in a Chinese population
    • Xiong, X.D.; Luo, X.P.; Liu, X.; Jing, X.; Zeng, L.Q.; Lei, M.; Hong, X.S.; Chen, Y. The MBD4 Glu346Lys polymorphism is associated with the risk of cervical cancer in a Chinese population. Int. J. Gynecol. Cancer 2012, 22, 1552-1556.
    • (2012) Int. J. Gynecol. Cancer , vol.22 , pp. 1552-1556
    • Xiong, X.D.1    Luo, X.P.2    Liu, X.3    Jing, X.4    Zeng, L.Q.5    Lei, M.6    Hong, X.S.7    Chen, Y.8
  • 138
    • 84902268880 scopus 로고    scopus 로고
    • Nuclear localization of Kaiso promotes the poorly differentiated phenotype and EMT in infiltrating ductal carcinomas
    • Jones, J.; Wang, H.; Karanam, B.; Theodore, S.; Dean-Colomb, W.; Welch, D.R.; Grizzle, W.; Yates, C. Nuclear localization of Kaiso promotes the poorly differentiated phenotype and EMT in infiltrating ductal carcinomas. Clin. Exp. Metastasis 2014, 31, 497-510.
    • (2014) Clin. Exp. Metastasis , vol.31 , pp. 497-510
    • Jones, J.1    Wang, H.2    Karanam, B.3    Theodore, S.4    Dean-Colomb, W.5    Welch, D.R.6    Grizzle, W.7    Yates, C.8
  • 141
    • 73249133400 scopus 로고    scopus 로고
    • Epigenetics: A molecular link between environmental factors and type 2 diabetes
    • Ling, C.; Groop, L. Epigenetics: A molecular link between environmental factors and type 2 diabetes. Diabetes 2009, 58, 2718-2725.
    • (2009) Diabetes , vol.58 , pp. 2718-2725
    • Ling, C.1    Groop, L.2
  • 143
    • 84897564607 scopus 로고    scopus 로고
    • Relationship between blood levels of methyl donor and folate and mild cognitive impairment in Chinese patients with type 2 diabetes: A case-control study
    • Zheng, M.; Zhang, M.; Yang, J.; Zhao, S.; Qin, S.; Chen, H.; Gao, Y.; Huang, G. Relationship between blood levels of methyl donor and folate and mild cognitive impairment in Chinese patients with type 2 diabetes: A case-control study. J. Clin. Biochem. Nutr. 2014, 54, 122-128.
    • (2014) J. Clin. Biochem. Nutr. , vol.54 , pp. 122-128
    • Zheng, M.1    Zhang, M.2    Yang, J.3    Zhao, S.4    Qin, S.5    Chen, H.6    Gao, Y.7    Huang, G.8
  • 144
    • 84862208421 scopus 로고    scopus 로고
    • Folate and vitamin B12 deficiency and hyperhomocysteinemia promote oxidative stress in adult type 2 diabetes
    • Al-Maskari, M.Y.; Waly, M.I.; Ali, A.; Al-Shuaibi, Y.S.; Ouhtit, A. Folate and vitamin B12 deficiency and hyperhomocysteinemia promote oxidative stress in adult type 2 diabetes. Nutrition 2012, 28, e23-e26.
    • (2012) Nutrition , vol.28 , pp. e23-e26
    • Al-Maskari, M.Y.1    Waly, M.I.2    Ali, A.3    Al-Shuaibi, Y.S.4    Ouhtit, A.5
  • 145
    • 23644439227 scopus 로고    scopus 로고
    • Homocysteine, vitamin B12 and folate in Alzheimer's and vascular dementias: The paradoxical effect of the superimposed type II diabetes mellitus condition
    • Dominguez, R.O.; Marschoff, E.R.; Guareschi, E.M.; Famulari, A.L.; Pagano, M.A.; Serra, J.A. Homocysteine, vitamin B12 and folate in Alzheimer's and vascular dementias: The paradoxical effect of the superimposed type II diabetes mellitus condition. Clin. Chim. Acta 2005, 359, 163-170.
    • (2005) Clin. Chim. Acta , vol.359 , pp. 163-170
    • Dominguez, R.O.1    Marschoff, E.R.2    Guareschi, E.M.3    Famulari, A.L.4    Pagano, M.A.5    Serra, J.A.6
  • 150
    • 84899690103 scopus 로고    scopus 로고
    • Correlation of CTGF gene promoter methylation with CTGF expression in type 2 diabetes mellitus with or without nephropathy
    • Zhang, H.; Cai, X.; Yi, B.; Huang, J.; Wang, J.; Sun, J. Correlation of CTGF gene promoter methylation with CTGF expression in type 2 diabetes mellitus with or without nephropathy. Mol. Med. Rep. 2014, 9, 2138-2144.
    • (2014) Mol. Med. Rep. , vol.9 , pp. 2138-2144
    • Zhang, H.1    Cai, X.2    Yi, B.3    Huang, J.4    Wang, J.5    Sun, J.6
  • 155
    • 14644417168 scopus 로고    scopus 로고
    • Diabetes mellitus type 1: Association with Rett syndrome
    • Kurtoglu, S.; Atabek, M.E.; Kumandas, S.; Keskin, M. Diabetes mellitus type 1: Association with Rett syndrome. Pediatr. Int. 2005, 47, 90-91.
    • (2005) Pediatr. Int. , vol.47 , pp. 90-91
    • Kurtoglu, S.1    Atabek, M.E.2    Kumandas, S.3    Keskin, M.4
  • 156
    • 77249087062 scopus 로고    scopus 로고
    • Genomic imprinting disorders in humans: A mini-review
    • Butler, M.G. Genomic imprinting disorders in humans: A mini-review. J. Assist. Reprod. Genet. 2009, 26, 477-486.
    • (2009) J. Assist. Reprod. Genet. , vol.26 , pp. 477-486
    • Butler, M.G.1
  • 160
    • 0036493248 scopus 로고    scopus 로고
    • Methylation-dependent silencing at the H19 imprinting control region by MeCP2
    • Drewell, R.A.; Goddard, C.J.; Thomas, J.O.; Surani, M.A. Methylation-dependent silencing at the H19 imprinting control region by MeCP2. Nucl. Acids Res. 2002, 30, 1139-1144.
    • (2002) Nucl. Acids Res. , vol.30 , pp. 1139-1144
    • Drewell, R.A.1    Goddard, C.J.2    Thomas, J.O.3    Surani, M.A.4
  • 161
    • 0037423186 scopus 로고    scopus 로고
    • The methyl-CpG-binding protein MeCP2 links DNA methylation to histone methylation
    • Fuks, F.; Hurd, P.J.; Wolf, D.; Nan, X.; Bird, A.P.; Kouzarides, T. The methyl-CpG-binding protein MeCP2 links DNA methylation to histone methylation. J. Biol. Chem. 2003, 278, 4035-4040.
    • (2003) J. Biol. Chem. , vol.278 , pp. 4035-4040
    • Fuks, F.1    Hurd, P.J.2    Wolf, D.3    Nan, X.4    Bird, A.P.5    Kouzarides, T.6
  • 162
    • 17744380972 scopus 로고    scopus 로고
    • MeCP2 deficiency in Rett syndrome causes epigenetic aberrations at the PWS/AS imprinting center that affects UBE3A expression
    • Makedonski, K.; Abuhatzira, L.; Kaufman, Y.; Razin, A.; Shemer, R. MeCP2 deficiency in Rett syndrome causes epigenetic aberrations at the PWS/AS imprinting center that affects UBE3A expression. Hum. Mol. Genet. 2005, 14, 1049-1058.
    • (2005) Hum. Mol. Genet. , vol.14 , pp. 1049-1058
    • Makedonski, K.1    Abuhatzira, L.2    Kaufman, Y.3    Razin, A.4    Shemer, R.5
  • 163
    • 14044252235 scopus 로고    scopus 로고
    • Epigenetic overlap in autism-spectrum neurodevelopmental disorders: MECP2 deficiency causes reduced expression of UBE3A and GABRB3
    • Samaco, R.C.; Hogart, A.; LaSalle, J.M. Epigenetic overlap in autism-spectrum neurodevelopmental disorders: MECP2 deficiency causes reduced expression of UBE3A and GABRB3. Hum. Mol. Genet. 2005, 14, 483-492.
    • (2005) Hum. Mol. Genet. , vol.14 , pp. 483-492
    • Samaco, R.C.1    Hogart, A.2    LaSalle, J.M.3
  • 164
    • 11244328520 scopus 로고    scopus 로고
    • Loss of silent-chromatin looping and impaired imprinting of DLX5 in Rett syndrome
    • Horike, S.; Cai, S.; Miyano, M.; Cheng, J.F.; Kohwi-Shigematsu, T. Loss of silent-chromatin looping and impaired imprinting of DLX5 in Rett syndrome. Nat. Genet. 2005, 37, 31-40.
    • (2005) Nat. Genet. , vol.37 , pp. 31-40
    • Horike, S.1    Cai, S.2    Miyano, M.3    Cheng, J.F.4    Kohwi-Shigematsu, T.5
  • 166
    • 84891546394 scopus 로고    scopus 로고
    • The control of hematopoietic stem cell maintenance, self-renewal, and differentiation by Mysm1-mediated epigenetic regulation
    • Wang, T.; Nandakumar, V.; Jiang, X.X.; Jones, L.; Yang, A.G.; Huang, X.F.; Chen, S.Y. The control of hematopoietic stem cell maintenance, self-renewal, and differentiation by Mysm1-mediated epigenetic regulation. Blood 2013, 122, 2812-2822.
    • (2013) Blood , vol.122 , pp. 2812-2822
    • Wang, T.1    Nandakumar, V.2    Jiang, X.X.3    Jones, L.4    Yang, A.G.5    Huang, X.F.6    Chen, S.Y.7
  • 167
    • 84875965163 scopus 로고    scopus 로고
    • Proliferation-dependent alterations of the DNA methylation landscape underlie hematopoietic stem cell aging
    • Beerman, I.; Bock, C.; Garrison, B.S.; Smith, Z.D.; Gu, H.; Meissner, A.; Rossi, D.J. Proliferation-dependent alterations of the DNA methylation landscape underlie hematopoietic stem cell aging. Cell Stem Cell 2013, 12, 413-425.
    • (2013) Cell Stem Cell , vol.12 , pp. 413-425
    • Beerman, I.1    Bock, C.2    Garrison, B.S.3    Smith, Z.D.4    Gu, H.5    Meissner, A.6    Rossi, D.J.7
  • 168
    • 84864612696 scopus 로고    scopus 로고
    • Genome-wide DNA methylation profiles in hematopoietic stem and progenitor cells reveal overrepresentation of ETS transcription factor binding sites
    • Hogart, A.; Lichtenberg, J.; Ajay, S.S.; Anderson, S.; Margulies, E.H.; Bodine, D.M. Genome-wide DNA methylation profiles in hematopoietic stem and progenitor cells reveal overrepresentation of ETS transcription factor binding sites. Genome Res. 2012, 22, 1407-1418.
    • (2012) Genome Res. , vol.22 , pp. 1407-1418
    • Hogart, A.1    Lichtenberg, J.2    Ajay, S.S.3    Anderson, S.4    Margulies, E.H.5    Bodine, D.M.6
  • 169
    • 84866406017 scopus 로고    scopus 로고
    • DNA methylation: A promising landscape for immune system-related diseases
    • Suarez-Alvarez, B.; Rodriguez, R.M.; Fraga, M.F.; Lopez-Larrea, C. DNA methylation: A promising landscape for immune system-related diseases. Trends Genet. 2012, 28, 506-514.
    • (2012) Trends Genet. , vol.28 , pp. 506-514
    • Suarez-Alvarez, B.1    Rodriguez, R.M.2    Fraga, M.F.3    Lopez-Larrea, C.4
  • 173
    • 84880899648 scopus 로고    scopus 로고
    • Overexpression of methyl-CpG-binding protein 2 and autoimmunity: Evidence from MECP2 duplication syndrome, lupus, MECP2 transgenic and Mecp2 deficient mice
    • Sawalha, A.H. Overexpression of methyl-CpG-binding protein 2 and autoimmunity: Evidence from MECP2 duplication syndrome, lupus, MECP2 transgenic and Mecp2 deficient mice. Lupus 2013, 22, 870-872.
    • (2013) Lupus , vol.22 , pp. 870-872
    • Sawalha, A.H.1
  • 175
    • 77954089823 scopus 로고    scopus 로고
    • Epigenetic therapeutics in autoimmune disease
    • Szyf, M. Epigenetic therapeutics in autoimmune disease. Clin. Rev. Allergy Immunol. 2010, 39, 62-77.
    • (2010) Clin. Rev. Allergy Immunol. , vol.39 , pp. 62-77
    • Szyf, M.1
  • 177
    • 34249690659 scopus 로고    scopus 로고
    • Transcript overexpression of the MBD2 and MBD4 genes in CD4+ T cells from systemic lupus erythematosus patients
    • Balada, E.; Ordi-Ros, J.; Serrano-Acedo, S.; Martinez-Lostao, L.; Vilardell-Tarres, M. Transcript overexpression of the MBD2 and MBD4 genes in CD4+ T cells from systemic lupus erythematosus patients. J. Leukoc. Biol. 2007, 81, 1609-1616.
    • (2007) J. Leukoc. Biol. , vol.81 , pp. 1609-1616
    • Balada, E.1    Ordi-Ros, J.2    Serrano-Acedo, S.3    Martinez-Lostao, L.4    Vilardell-Tarres, M.5
  • 178
  • 179
    • 79957463780 scopus 로고    scopus 로고
    • Epigenetic modifications: Basic mechanisms and role in cardiovascular disease
    • Handy, D.E.; Castro, R.; Loscalzo, J. Epigenetic modifications: Basic mechanisms and role in cardiovascular disease. Circulation 2011, 123, 2145-2156.
    • (2011) Circulation , vol.123 , pp. 2145-2156
    • Handy, D.E.1    Castro, R.2    Loscalzo, J.3
  • 182
    • 0035807767 scopus 로고    scopus 로고
    • Effects of cerebral ischemia in mice lacking DNA methyltransferase 1 in post-mitotic neurons
    • Endres, M.; Fan, G.; Meisel, A.; Dirnagl, U.; Jaenisch, R. Effects of cerebral ischemia in mice lacking DNA methyltransferase 1 in post-mitotic neurons. Neuroreport 2001, 12, 3763-3766.
    • (2001) Neuroreport , vol.12 , pp. 3763-3766
    • Endres, M.1    Fan, G.2    Meisel, A.3    Dirnagl, U.4    Jaenisch, R.5
  • 187
    • 0027362621 scopus 로고
    • CTCF, a conserved nuclear factor required for optimal transcriptional activity of the chicken c-myc gene, is an 11-Zn-finger protein differentially expressed in multiple forms
    • Klenova, E.M.; Nicolas, R.H.; Paterson, H.F.; Carne, A.F.; Heath, C.M.; Goodwin, G.H.; Neiman, P.E.; Lobanenkov, V.V. CTCF, a conserved nuclear factor required for optimal transcriptional activity of the chicken c-myc gene, is an 11-Zn-finger protein differentially expressed in multiple forms. Mol. Cell. Biol. 1993, 13, 7612-7624.
    • (1993) Mol. Cell. Biol. , vol.13 , pp. 7612-7624
    • Klenova, E.M.1    Nicolas, R.H.2    Paterson, H.F.3    Carne, A.F.4    Heath, C.M.5    Goodwin, G.H.6    Neiman, P.E.7    Lobanenkov, V.V.8
  • 188
    • 2442716497 scopus 로고    scopus 로고
    • Role of CTCF binding sites in the Igf2/H19 imprinting control region
    • Szabo, P.E.; Tang, S.H.; Silva, F.J.; Tsark, W.M.; Mann, J.R. Role of CTCF binding sites in the Igf2/H19 imprinting control region. Mol. Cell. Biol. 2004, 24, 4791-4800.
    • (2004) Mol. Cell. Biol. , vol.24 , pp. 4791-4800
    • Szabo, P.E.1    Tang, S.H.2    Silva, F.J.3    Tsark, W.M.4    Mann, J.R.5
  • 189
    • 65649115253 scopus 로고    scopus 로고
    • CTCF and its protein partners: Divide and rule?
    • Zlatanova, J.; Caiafa, P. CTCF and its protein partners: Divide and rule? J. Cell Sci. 2009, 122, 1275-1284.
    • (2009) J. Cell Sci. , vol.122 , pp. 1275-1284
    • Zlatanova, J.1    Caiafa, P.2
  • 190
    • 48949085110 scopus 로고    scopus 로고
    • Cohesin and CTCF: Cooperating to control chromosome conformation?
    • Gause, M.; Schaaf, C.A.; Dorsett, D. Cohesin and CTCF: Cooperating to control chromosome conformation? Bioessays 2008, 30, 715-718.
    • (2008) Bioessays , vol.30 , pp. 715-718
    • Gause, M.1    Schaaf, C.A.2    Dorsett, D.3
  • 192
    • 33845969545 scopus 로고    scopus 로고
    • Identification of a Ctcf cofactor, YY1, for the X chromosome binary switch
    • Donohoe, M.E.; Zhang, L.F.; Xu, N.; Shi, Y.; Lee, J.T. Identification of a Ctcf cofactor, YY1, for the X chromosome binary switch. Mol. Cell 2007, 25, 43-56.
    • (2007) Mol. Cell , vol.25 , pp. 43-56
    • Donohoe, M.E.1    Zhang, L.F.2    Xu, N.3    Shi, Y.4    Lee, J.T.5
  • 195
    • 67649443764 scopus 로고    scopus 로고
    • Aberrant epigenetic modifications in the CTCF binding domain of the IGF2/H19 gene in prostate cancer compared with benign prostate hyperplasia
    • Paradowska, A.; Fenic, I.; Konrad, L.; Sturm, K.; Wagenlehner, F.; Weidner, W.; Steger, K. Aberrant epigenetic modifications in the CTCF binding domain of the IGF2/H19 gene in prostate cancer compared with benign prostate hyperplasia. Int. J. Oncol. 2009, 35, 87-96.
    • (2009) Int. J. Oncol. , vol.35 , pp. 87-96
    • Paradowska, A.1    Fenic, I.2    Konrad, L.3    Sturm, K.4    Wagenlehner, F.5    Weidner, W.6    Steger, K.7
  • 196
    • 79951840526 scopus 로고    scopus 로고
    • CTCF and BORIS regulate Rb2/p130 gene transcription: A novel mechanism and a new paradigm for understanding the biology of lung cancer
    • Fiorentino, F.P.; Macaluso, M.; Miranda, F.; Montanari, M.; Russo, A.; Bagella, L.; Giordano, A. CTCF and BORIS regulate Rb2/p130 gene transcription: A novel mechanism and a new paradigm for understanding the biology of lung cancer. Mol. Cancer Res. 2011, 9, 225-233.
    • (2011) Mol. Cancer Res. , vol.9 , pp. 225-233
    • Fiorentino, F.P.1    McAluso, M.2    Miranda, F.3    Montanari, M.4    Russo, A.5    Bagella, L.6    Giordano, A.7
  • 197
    • 0035895208 scopus 로고    scopus 로고
    • Loss of imprinting of the insulin-like growth factor II gene occurs by biallelic methylation in a core region of H19-associated CTCF-binding sites in colorectal cancer
    • Nakagawa, H.; Chadwick, R.B.; Peltomaki, P.; Plass, C.; Nakamura, Y.; de La Chapelle, A. Loss of imprinting of the insulin-like growth factor II gene occurs by biallelic methylation in a core region of H19-associated CTCF-binding sites in colorectal cancer. Proc. Natl. Acad. Sci. USA 2001, 98, 591-596.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 591-596
    • Nakagawa, H.1    Chadwick, R.B.2    Peltomaki, P.3    Plass, C.4    Nakamura, Y.5    de La Chapelle, A.6
  • 198
    • 0037389185 scopus 로고    scopus 로고
    • Beckwith-Wiedemann syndrome demonstrates a role for epigenetic control of normal development
    • Weksberg, R.; Smith, A.C.; Squire, J.; Sadowski, P. Beckwith-Wiedemann syndrome demonstrates a role for epigenetic control of normal development. Hum. Mol. Genet. 2003, 12, R61-R68.
    • (2003) Hum. Mol. Genet. , vol.12 , pp. R61-R68
    • Weksberg, R.1    Smith, A.C.2    Squire, J.3    Sadowski, P.4
  • 200
    • 79951669837 scopus 로고    scopus 로고
    • The basics of brain development
    • Stiles, J.; Jernigan, T.L. The basics of brain development. Neuropsychol. Rev. 2010, 20, 327-348.
    • (2010) Neuropsychol. Rev. , vol.20 , pp. 327-348
    • Stiles, J.1    Jernigan, T.L.2
  • 205
    • 84870675094 scopus 로고    scopus 로고
    • DNA methylation program during development
    • Zhou, F.C. DNA methylation program during development. Front. Biol. (Beijing) 2012, 7, 485-494.
    • (2012) Front. Biol. (Beijing) , vol.7 , pp. 485-494
    • Zhou, F.C.1
  • 207
    • 84875409508 scopus 로고    scopus 로고
    • DNA methylation program in developing hippocampus and its alteration by alcohol
    • Chen, Y.; Ozturk, N.C.; Zhou, F.C. DNA methylation program in developing hippocampus and its alteration by alcohol. PLoS One 2013, 8, e60503.
    • (2013) PLoS One , vol.8
    • Chen, Y.1    Ozturk, N.C.2    Zhou, F.C.3
  • 209
    • 84893740377 scopus 로고    scopus 로고
    • Distribution, recognition and regulation of non-CpG methylation in the adult mammalian brain
    • Guo, J.U.; Su, Y.; Shin, J.H.; Shin, J.; Li, H.; Xie, B.; Zhong, C.; Hu, S.; Le, T.; Fan, G.; et al. Distribution, recognition and regulation of non-CpG methylation in the adult mammalian brain. Nat. Neurosci. 2014, 17, 215-222.
    • (2014) Nat. Neurosci. , vol.17 , pp. 215-222
    • Guo, J.U.1    Su, Y.2    Shin, J.H.3    Shin, J.4    Li, H.5    Xie, B.6    Zhong, C.7    Hu, S.8    Le, T.9    Fan, G.10
  • 210
    • 79960118297 scopus 로고    scopus 로고
    • A genomic point-of-view on environmental factors influencing the human brain methylome
    • LaSalle, J.M. A genomic point-of-view on environmental factors influencing the human brain methylome. Epigenetics 2011, 6, 862-869.
    • (2011) Epigenetics , vol.6 , pp. 862-869
    • LaSalle, J.M.1
  • 211
    • 79953740450 scopus 로고    scopus 로고
    • Prenatal environmental exposures, epigenetics, and disease
    • Perera, F.; Herbstman, J. Prenatal environmental exposures, epigenetics, and disease. Reprod. Toxicol. 2011, 31, 363-373.
    • (2011) Reprod. Toxicol. , vol.31 , pp. 363-373
    • Perera, F.1    Herbstman, J.2
  • 213
    • 84874642999 scopus 로고    scopus 로고
    • Prenatal substance abuse: Short- and long-term effects on the exposed fetus
    • Behnke, M.; Smith, V.C. Prenatal substance abuse: Short- and long-term effects on the exposed fetus. Pediatrics 2013, 131, e1009-e1024.
    • (2013) Pediatrics , vol.131 , pp. e1009-e1024
    • Behnke, M.1    Smith, V.C.2
  • 214
    • 84863341417 scopus 로고    scopus 로고
    • Reversal of cocaine-conditioned place preference through methyl supplementation in mice: Altering global DNA methylation in the prefrontal cortex
    • Tian, W.; Zhao, M.; Li, M.; Song, T.; Zhang, M.; Quan, L.; Li, S.; Sun, Z.S. Reversal of cocaine-conditioned place preference through methyl supplementation in mice: Altering global DNA methylation in the prefrontal cortex. PLoS One 2012, 7, e33435.
    • (2012) PLoS One , vol.7
    • Tian, W.1    Zhao, M.2    Li, M.3    Song, T.4    Zhang, M.5    Quan, L.6    Li, S.7    Sun, Z.S.8
  • 215
    • 55849115277 scopus 로고    scopus 로고
    • Nicotine decreases DNA methyltransferase 1 expression and glutamic acid decarboxylase 67 promoter methylation in GABAergic interneurons
    • Satta, R.; Maloku, E.; Zhubi, A.; Pibiri, F.; Hajos, M.; Costa, E.; Guidotti, A. Nicotine decreases DNA methyltransferase 1 expression and glutamic acid decarboxylase 67 promoter methylation in GABAergic interneurons. PNAS 2008, 105, 16356-16361.
    • (2008) PNAS , vol.105 , pp. 16356-16361
    • Satta, R.1    Maloku, E.2    Zhubi, A.3    Pibiri, F.4    Hajos, M.5    Costa, E.6    Guidotti, A.7
  • 216
    • 73449131530 scopus 로고    scopus 로고
    • Alcohol exposure alters DNA methylation profiles in mouse embryos at early neurulation
    • Liu, Y.; Balaraman, Y.; Wang, G.; Nephew, K.P.; Zhou, F.C. Alcohol exposure alters DNA methylation profiles in mouse embryos at early neurulation. Epigenetics 2009, 4, 500-511.
    • (2009) Epigenetics , vol.4 , pp. 500-511
    • Liu, Y.1    Balaraman, Y.2    Wang, G.3    Nephew, K.P.4    Zhou, F.C.5
  • 217
  • 219
    • 84901190217 scopus 로고    scopus 로고
    • One-carbon metabolism and risk factors for its disturbance
    • Kruman, I.; Fowler, A.-K. One-carbon metabolism and risk factors for its disturbance. J. Neurochem. 2014, 129, 770-780.
    • (2014) J. Neurochem. , vol.129 , pp. 770-780
    • Kruman, I.1    Fowler, A.-K.2
  • 220
    • 84880011207 scopus 로고    scopus 로고
    • Long-lasting alterations to DNA methylation and ncRNAs could underlie the effects of fetal alcohol exposure in mice
    • Laufer, B.I.; Mantha, K.; Kleiber, M.L.; Diehl, E.J.; Addison, S.M.F.; Singh, S.M. Long-lasting alterations to DNA methylation and ncRNAs could underlie the effects of fetal alcohol exposure in mice. Dis. Model. Mech. 2013, 6, 977-992.
    • (2013) Dis. Model. Mech. , vol.6 , pp. 977-992
    • Laufer, B.I.1    Mantha, K.2    Kleiber, M.L.3    Diehl, E.J.4    Addison, S.M.F.5    Singh, S.M.6
  • 221
    • 0036119978 scopus 로고    scopus 로고
    • Paternal alcohol exposure affects sperm cytosine methyltransferase messenger RNA levels
    • Bielawski, D.M.; Zaher, F.M.; Svinarich, D.M.; Abel, E.L. Paternal alcohol exposure affects sperm cytosine methyltransferase messenger RNA levels. Alcohol. Clin. Exp. Res. 2002, 26, 347-351.
    • (2002) Alcohol. Clin. Exp. Res. , vol.26 , pp. 347-351
    • Bielawski, D.M.1    Zaher, F.M.2    Svinarich, D.M.3    Abel, E.L.4
  • 222
    • 69249083264 scopus 로고    scopus 로고
    • Effect of alcohol consumption on CpG methylation in the differentially methylated regions of H19 and IG-DMR in male gametes: Implications for fetal alcohol spectrum disorders
    • Ouko, L.A.; Shantikumar, K.; Knezovich, J.; Haycock, P.; Schnugh, D.J.; Ramsay, M. Effect of alcohol consumption on CpG methylation in the differentially methylated regions of H19 and IG-DMR in male gametes: Implications for fetal alcohol spectrum disorders. Alcohol. Clin. Exp. Res. 2009, 33, 1615-1627.
    • (2009) Alcohol. Clin. Exp. Res. , vol.33 , pp. 1615-1627
    • Ouko, L.A.1    Shantikumar, K.2    Knezovich, J.3    Haycock, P.4    Schnugh, D.J.5    Ramsay, M.6
  • 223
    • 79956357684 scopus 로고    scopus 로고
    • Prenatal exposure to ethanol: A specific effect on the H19 gene in sperm
    • Stouder, C.; Somm, E.; Paoloni-Giacobino, A. Prenatal exposure to ethanol: A specific effect on the H19 gene in sperm. Reprod. Toxicol. 2011, 31, 507-512.
    • (2011) Reprod. Toxicol. , vol.31 , pp. 507-512
    • Stouder, C.1    Somm, E.2    Paoloni-Giacobino, A.3
  • 224
    • 84870567826 scopus 로고    scopus 로고
    • The effect of preconception paternal alcohol exposure on epigenetic remodeling of the h19 and rasgrf1 imprinting control regions in mouse offspring
    • Knezovich, J.G.; Ramsay, M. The effect of preconception paternal alcohol exposure on epigenetic remodeling of the h19 and rasgrf1 imprinting control regions in mouse offspring. Front. Genet. 2012, 3, 10.
    • (2012) Front. Genet. , vol.3 , pp. 10
    • Knezovich, J.G.1    Ramsay, M.2
  • 225
    • 84889662331 scopus 로고    scopus 로고
    • Placental DNA methylation alterations associated with maternal tobacco smoking at the RUNX3 gene are also associated with gestational age
    • Maccani, J.Z.; Koestler, D.C.; Houseman, E.A.; Marsit, C.J.; Kelsey, K.T. Placental DNA methylation alterations associated with maternal tobacco smoking at the RUNX3 gene are also associated with gestational age. Epigenomics 2013, 5, 619-630.
    • (2013) Epigenomics , vol.5 , pp. 619-630
    • McCani, J.Z.1    Koestler, D.C.2    Houseman, E.A.3    Marsit, C.J.4    Kelsey, K.T.5
  • 227
    • 84865588279 scopus 로고    scopus 로고
    • Perinatal nicotine exposure increases vulnerability of hypoxic-ischemic brain injury in neonatal rats: Role of angiotensin II receptors
    • Li, Y.; Xiao, D.; Dasgupta, C.; Xiong, F.; Tong, W.; Yang, S.; Zhang, L. Perinatal nicotine exposure increases vulnerability of hypoxic-ischemic brain injury in neonatal rats: Role of angiotensin II receptors. Stroke 2012, 43, 2483-2490.
    • (2012) Stroke , vol.43 , pp. 2483-2490
    • Li, Y.1    Xiao, D.2    Dasgupta, C.3    Xiong, F.4    Tong, W.5    Yang, S.6    Zhang, L.7
  • 230
    • 84878013298 scopus 로고    scopus 로고
    • Gender differences in neurodevelopment and epigenetics
    • Chung, W.C.; Auger, A.P. Gender differences in neurodevelopment and epigenetics. Pflugers Arch. 2013, 465, 573-584.
    • (2013) Pflugers Arch. , vol.465 , pp. 573-584
    • Chung, W.C.1    Auger, A.P.2
  • 232
    • 84904795930 scopus 로고    scopus 로고
    • Environmental tobacco smoke exposure and brain development: The case of attention deficit/hyperactivity disorder
    • Pagani, L.S. Environmental tobacco smoke exposure and brain development: The case of attention deficit/hyperactivity disorder. Neurosci. Biobehav. Rev. 2014, doi:10.1016/j.neubiorev.2013.03.008.
    • (2014) Neurosci. Biobehav. Rev.
    • Pagani, L.S.1
  • 233
    • 44849092317 scopus 로고    scopus 로고
    • Maternal cocaine administration in mice alters DNA methylation and gene expression in hippocampal neurons of neonatal and prepubertal offspring
    • Novikova, S.I.; He, F.; Bai, J.; Cutrufello, N.J.; Lidow, M.S.; Undieh, A.S. Maternal cocaine administration in mice alters DNA methylation and gene expression in hippocampal neurons of neonatal and prepubertal offspring. PLoS One 2008, 3, e1919.
    • (2008) PLoS One , vol.3
    • Novikova, S.I.1    He, F.2    Bai, J.3    Cutrufello, N.J.4    Lidow, M.S.5    Undieh, A.S.6
  • 235
    • 12244279345 scopus 로고    scopus 로고
    • Specific method for the determination of genomic DNA methylation by liquid chromatography-electrospray ionization tandem mass spectrometry
    • Song, L.; James, S.R.; Kazim, L.; Karpf, A.R. Specific method for the determination of genomic DNA methylation by liquid chromatography-electrospray ionization tandem mass spectrometry. Anal. Chem. 2005, 77, 504-510.
    • (2005) Anal. Chem. , vol.77 , pp. 504-510
    • Song, L.1    James, S.R.2    Kazim, L.3    Karpf, A.R.4
  • 236
    • 84938550785 scopus 로고    scopus 로고
    • Long-term parental methamphetamine exposure of mice influences behavior and hippocampal DNA methylation of the offspring
    • Itzhak, Y.; Ergui, I.; Young, J.I. Long-term parental methamphetamine exposure of mice influences behavior and hippocampal DNA methylation of the offspring. Mol. Psychiatry 2014, doi:10.1038/mp.2014.7.
    • (2014) Mol. Psychiatry
    • Itzhak, Y.1    Ergui, I.2    Young, J.I.3
  • 237
    • 84875249758 scopus 로고    scopus 로고
    • Effect of chronic heroin and cocaine administration on global DNA methylation in brain and liver
    • Fragou, D.; Zanos, P.; Kouidou, S.; Njau, S.; Kitchen, I.; Bailey, A.; Kovatsi, L. Effect of chronic heroin and cocaine administration on global DNA methylation in brain and liver. Toxicol. Lett. 2013, 218, 260-265.
    • (2013) Toxicol. Lett. , vol.218 , pp. 260-265
    • Fragou, D.1    Zanos, P.2    Kouidou, S.3    Njau, S.4    Kitchen, I.5    Bailey, A.6    Kovatsi, L.7
  • 238
    • 84870525593 scopus 로고    scopus 로고
    • A comparison of the whole genome approach of MeDIP-seq to the targeted approach of the Infinium HumanMethylation450 BeadChip® for methylome profiling
    • Clark, C.; Palta, P.; Joyce, C.J.; Scott, C.; Grundberg, E.; Deloukas, P.; Palotie, A.; Coffey, A.J. A comparison of the whole genome approach of MeDIP-seq to the targeted approach of the Infinium HumanMethylation450 BeadChip® for methylome profiling. PLoS One 2012, 7, e50233.
    • (2012) PLoS One , vol.7
    • Clark, C.1    Palta, P.2    Joyce, C.J.3    Scott, C.4    Grundberg, E.5    Deloukas, P.6    Palotie, A.7    Coffey, A.J.8
  • 239
    • 84875451684 scopus 로고    scopus 로고
    • The genetic and epigenetic journey of embryonic stem cells into mature neural cells
    • Olynik, B.M.; Rastegar, M. The genetic and epigenetic journey of embryonic stem cells into mature neural cells. Front. Genet. 2012, 3, 81.
    • (2012) Front. Genet. , vol.3 , pp. 81
    • Olynik, B.M.1    Rastegar, M.2
  • 240
    • 84897015163 scopus 로고    scopus 로고
    • MeCP2-related diseases and animal models
    • Ezeonwuka, C.; Rastegar, M. MeCP2-related diseases and animal models. Diseases 2014, 2, 45-70.
    • (2014) Diseases , vol.2 , pp. 45-70
    • Ezeonwuka, C.1    Rastegar, M.2
  • 241
    • 0037081840 scopus 로고    scopus 로고
    • Insight into Rett syndrome: MeCP2 levels display tissue- and cell-specific differences and correlate with neuronal maturation
    • Shahbazian, M.D.; Antalffy, B.; Armstrong, D.L.; Zoghbi, H.Y. Insight into Rett syndrome: MeCP2 levels display tissue- and cell-specific differences and correlate with neuronal maturation. Hum. Mol. Genet. 2002, 11, 115-124.
    • (2002) Hum. Mol. Genet. , vol.11 , pp. 115-124
    • Shahbazian, M.D.1    Antalffy, B.2    Armstrong, D.L.3    Zoghbi, H.Y.4
  • 242
    • 84896991213 scopus 로고    scopus 로고
    • Brain region-specific expression of MeCP2 isoforms correlates with DNA methylation within Mecp2 regulatory elements
    • Olson, C.O.; Zachariah, R.M.; Ezeonwuka, C.D.; Liyanage, V.R.; Rastegar, M. Brain region-specific expression of MeCP2 isoforms correlates with DNA methylation within Mecp2 regulatory elements. PLoS One 2014, 9, e90645.
    • (2014) PLoS One , vol.9
    • Olson, C.O.1    Zachariah, R.M.2    Ezeonwuka, C.D.3    Liyanage, V.R.4    Rastegar, M.5
  • 243
    • 84887526206 scopus 로고    scopus 로고
    • Decitabine alters the expression of Mecp2 isoforms via dynamic DNA methylation at the Mecp2 regulatory elements in neural stem cells
    • Liyanage, V.R.; Zachariah, R.M.; Rastegar, M. Decitabine alters the expression of Mecp2 isoforms via dynamic DNA methylation at the Mecp2 regulatory elements in neural stem cells. Mol. Autism 2013, 4, 46.
    • (2013) Mol. Autism , vol.4 , pp. 46
    • Liyanage, V.R.1    Zachariah, R.M.2    Rastegar, M.3
  • 246
    • 0032830639 scopus 로고    scopus 로고
    • Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2
    • Amir, R.E.; van den Veyver, I.B.; Wan, M.; Tran, C.Q.; Francke, U.; Zoghbi, H.Y. Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2. Nat. Genet. 1999, 23, 185-188.
    • (1999) Nat. Genet. , vol.23 , pp. 185-188
    • Amir, R.E.1    van den Veyver, I.B.2    Wan, M.3    Tran, C.Q.4    Francke, U.5    Zoghbi, H.Y.6
  • 249
    • 34247095504 scopus 로고    scopus 로고
    • Reduced MeCP2 expression is frequent in autism frontal cortex and correlates with aberrant MECP2 promoter methylation
    • Nagarajan, R.P.; Hogart, A.R.; Gwye, Y.; Martin, M.R.; LaSalle, J.M. Reduced MeCP2 expression is frequent in autism frontal cortex and correlates with aberrant MECP2 promoter methylation. Epigenetics 2006, 1, e1-e11.
    • (2006) Epigenetics , vol.1 , pp. e1-e11
    • Nagarajan, R.P.1    Hogart, A.R.2    Gwye, Y.3    Martin, M.R.4    LaSalle, J.M.5
  • 250
    • 80052865785 scopus 로고    scopus 로고
    • Autism-associated gene expression in peripheral leucocytes commonly observed between subjects with autism and healthy women having autistic children
    • Kuwano, Y.; Kamio, Y.; Kawai, T.; Katsuura, S.; Inada, N.; Takaki, A.; Rokutan, K. Autism-associated gene expression in peripheral leucocytes commonly observed between subjects with autism and healthy women having autistic children. PLoS One 2011, 6, e24723.
    • (2011) PLoS One , vol.6
    • Kuwano, Y.1    Kamio, Y.2    Kawai, T.3    Katsuura, S.4    Inada, N.5    Takaki, A.6    Rokutan, K.7
  • 252
  • 258
    • 84865085089 scopus 로고    scopus 로고
    • A case report of Chinese brothers with inherited MECP2-containing duplication: Autism and intellectual disability, but not seizures or respiratory infections
    • Xu, X.; Xu, Q.; Zhang, Y.; Zhang, X.; Cheng, T.; Wu, B.; Ding, Y.; Lu, P.; Zheng, J.; Zhang, M.; Qiu, Z.; Yu, X. A case report of Chinese brothers with inherited MECP2-containing duplication: Autism and intellectual disability, but not seizures or respiratory infections. BMC Med. Genet. 2012, 13, 75.
    • (2012) BMC Med. Genet. , vol.13 , pp. 75
    • Xu, X.1    Xu, Q.2    Zhang, Y.3    Zhang, X.4    Cheng, T.5    Wu, B.6    Ding, Y.7    Lu, P.8    Zheng, J.9    Zhang, M.10    Qiu, Z.11    Yu, X.12
  • 259
  • 260
    • 84874759852 scopus 로고    scopus 로고
    • An AT-hook domain in MeCP2 determines the clinical course of Rett syndrome and related disorders
    • Baker, S.A.; Chen, L.; Wilkins, A.D.; Yu, P.; Lichtarge, O.; Zoghbi, H.Y. An AT-hook domain in MeCP2 determines the clinical course of Rett syndrome and related disorders. Cell 2013, 152, 984-996.
    • (2013) Cell , vol.152 , pp. 984-996
    • Baker, S.A.1    Chen, L.2    Wilkins, A.D.3    Yu, P.4    Lichtarge, O.5    Zoghbi, H.Y.6
  • 261
    • 84876419344 scopus 로고    scopus 로고
    • Effects of ethanol exposure during early pregnancy in hyperactive, inattentive and impulsive behaviors and MeCP2 expression in rodent offspring
    • Kim, P.; Park, J.H.; Choi, C.S.; Choi, I.; Joo, S.H.; Kim, M.K.; Kim, S.Y.; Kim, K.C.; Park, S.H.; Kwon, K.J.; et al. Effects of ethanol exposure during early pregnancy in hyperactive, inattentive and impulsive behaviors and MeCP2 expression in rodent offspring. Neurochem. Res. 2013, 38, 620-631.
    • (2013) Neurochem. Res. , vol.38 , pp. 620-631
    • Kim, P.1    Park, J.H.2    Choi, C.S.3    Choi, I.4    Joo, S.H.5    Kim, M.K.6    Kim, S.Y.7    Kim, K.C.8    Park, S.H.9    Kwon, K.J.10
  • 262
    • 84866483096 scopus 로고    scopus 로고
    • Maternal separation and proclivity for ethanol intake: A potential role of the endocannabinoid system in rats
    • Romano-Lopez, A.; Mendez-Diaz, M.; Ruiz-Contreras, A.E.; Carrisoza, R.; Prospero-Garcia, O. Maternal separation and proclivity for ethanol intake: A potential role of the endocannabinoid system in rats. Neuroscience 2012, 223, 296-304.
    • (2012) Neuroscience , vol.223 , pp. 296-304
    • Romano-Lopez, A.1    Mendez-Diaz, M.2    Ruiz-Contreras, A.E.3    Carrisoza, R.4    Prospero-Garcia, O.5
  • 264
    • 84886445160 scopus 로고    scopus 로고
    • Low-dose thyroxine attenuates autism-associated adverse effects of fetal alcohol in male offspring's social behavior and hippocampal gene expression
    • Tunc-Ozcan, E.; Ullmann, T.M.; Shukla, P.K.; Redei, E.E. Low-dose thyroxine attenuates autism-associated adverse effects of fetal alcohol in male offspring's social behavior and hippocampal gene expression. Alcohol. Clin. Exp. Res. 2013, 37, 1986-1995.
    • (2013) Alcohol. Clin. Exp. Res. , vol.37 , pp. 1986-1995
    • Tunc-Ozcan, E.1    Ullmann, T.M.2    Shukla, P.K.3    Redei, E.E.4
  • 265
    • 84895926404 scopus 로고    scopus 로고
    • Chronic exposure to ethanol of male mice before mating produces attention deficit hyperactivity disorder-like phenotype along with epigenetic dysregulation of dopamine transporter expression in mouse offspring
    • Kim, P.; Choi, C.S.; Park, J.H.; Joo, S.H.; Kim, S.Y.; Ko, H.M.; Kim, K.C.; Jeon, S.J.; Park, S.H.; Han, S.H.; et al. Chronic exposure to ethanol of male mice before mating produces attention deficit hyperactivity disorder-like phenotype along with epigenetic dysregulation of dopamine transporter expression in mouse offspring. J. Neurosci. Res. 2014, 92, 658-670.
    • (2014) J. Neurosci. Res. , vol.92 , pp. 658-670
    • Kim, P.1    Choi, C.S.2    Park, J.H.3    Joo, S.H.4    Kim, S.Y.5    Ko, H.M.6    Kim, K.C.7    Jeon, S.J.8    Park, S.H.9    Han, S.H.10
  • 266
    • 84879884147 scopus 로고    scopus 로고
    • Gestational choline supplementation normalized fetal alcohol-induced alterations in histone modifications, DNA methylation, and proopiomelanocortin (POMC) gene expression in beta-endorphin-producing POMC neurons of the hypothalamus
    • Bekdash, R.A.; Zhang, C.; Sarkar, D.K. Gestational choline supplementation normalized fetal alcohol-induced alterations in histone modifications, DNA methylation, and proopiomelanocortin (POMC) gene expression in beta-endorphin-producing POMC neurons of the hypothalamus. Alcohol. Clin. Exp. Res. 2013, 37, 1133-1142.
    • (2013) Alcohol. Clin. Exp. Res. , vol.37 , pp. 1133-1142
    • Bekdash, R.A.1    Zhang, C.2    Sarkar, D.K.3
  • 267
    • 84891368499 scopus 로고    scopus 로고
    • Ethanol induced acetylation of histone at G9a exon1 and G9a-mediated histone H3 dimethylation leads to neurodegeneration in neonatal mice
    • Subbanna, S.; Nagre, N.N.; Shivakumar, M.; Umapathy, N.S.; Psychoyos, D.; Basavarajappa, B.S. Ethanol induced acetylation of histone at G9a exon1 and G9a-mediated histone H3 dimethylation leads to neurodegeneration in neonatal mice. Neuroscience 2014, 258, 422-432.
    • (2014) Neuroscience , vol.258 , pp. 422-432
    • Subbanna, S.1    Nagre, N.N.2    Shivakumar, M.3    Umapathy, N.S.4    Psychoyos, D.5    Basavarajappa, B.S.6
  • 269
    • 31044454138 scopus 로고    scopus 로고
    • The expanding role of BDNF: A therapeutic target for Alzheimer's disease?
    • Fumagalli, F.; Racagni, G.; Riva, M.A. The expanding role of BDNF: A therapeutic target for Alzheimer's disease? Pharmacogenomics J. 2006, 6, 8-15.
    • (2006) Pharmacogenomics J. , vol.6 , pp. 8-15
    • Fumagalli, F.1    Racagni, G.2    Riva, M.A.3
  • 271
    • 0035054930 scopus 로고    scopus 로고
    • Angelman syndrome phenotype associated with mutations in MECP2, a gene encoding a methyl CpG binding protein
    • Watson, P.; Black, G.; Ramsden, S.; Barrow, M.; Super, M.; Kerr, B.; Clayton-Smith, J. Angelman syndrome phenotype associated with mutations in MECP2, a gene encoding a methyl CpG binding protein. J. Med. Genet. 2001, 38, 224-228.
    • (2001) J. Med. Genet. , vol.38 , pp. 224-228
    • Watson, P.1    Black, G.2    Ramsden, S.3    Barrow, M.4    Super, M.5    Kerr, B.6    Clayton-Smith, J.7
  • 272
    • 84887129061 scopus 로고    scopus 로고
    • Strategies for discovery and validation of methylated and hydroxymethylated DNA biomarkers
    • Olkhov-Mitsel, E.; Bapat, B. Strategies for discovery and validation of methylated and hydroxymethylated DNA biomarkers. Cancer Med. 2012, 1, 237-260.
    • (2012) Cancer Med. , vol.1 , pp. 237-260
    • Olkhov-Mitsel, E.1    Bapat, B.2
  • 274
    • 84875700729 scopus 로고    scopus 로고
    • A cell epigenotype specific model for the correction of brain cellular heterogeneity bias and its application to age, brain region and major depression
    • Guintivano, J.; Aryee, M.J.; Kaminsky, Z.A. A cell epigenotype specific model for the correction of brain cellular heterogeneity bias and its application to age, brain region and major depression. Epigenetics 2013, 8, 290-302.
    • (2013) Epigenetics , vol.8 , pp. 290-302
    • Guintivano, J.1    Aryee, M.J.2    Kaminsky, Z.A.3
  • 275
    • 84902513825 scopus 로고    scopus 로고
    • Prevalence of prediabetes in England from 2003 to 2011: Population-based, cross-sectional study
    • Mainous, A., 3rd; Tanner, R.; Baker, R.; Zayas, C.; Harle, C. Prevalence of prediabetes in England from 2003 to 2011: Population-based, cross-sectional study. BMJ Open 2014, 4, e005002.
    • (2014) BMJ Open , vol.4
    • Mainous, A.1    Tanner, R.2    Baker, R.3    Zayas, C.4    Harle, C.5
  • 277
    • 84897452599 scopus 로고    scopus 로고
    • Genome-wide DNA methylation analysis of human pancreatic islets from type 2 diabetic and non-diabetic donors identifies candidate genes that influence insulin secretion
    • Dayeh, T.; Volkov, P.; Salö, S.; Hall, E.; Nilsson, E.; Olsson, A.H.; Kirkpatrick, C.L.; Wollheim, C.B.; Eliasson, L.; Rönn, T.; et al. Genome-wide DNA methylation analysis of human pancreatic islets from type 2 diabetic and non-diabetic donors identifies candidate genes that influence insulin secretion. PLoS Genet. 2014, 10, e1004160.
    • (2014) PLoS Genet. , vol.10
    • Dayeh, T.1    Volkov, P.2    Salö, S.3    Hall, E.4    Nilsson, E.5    Olsson, A.H.6    Kirkpatrick, C.L.7    Wollheim, C.B.8    Eliasson, L.9    Rönn, T.10
  • 279
  • 280
    • 84856269241 scopus 로고    scopus 로고
    • DNA methylation as clinically useful biomarkers-light at the end of the tunnel
    • Levenson, V.V.; Melnikov, A.A. DNA methylation as clinically useful biomarkers-light at the end of the tunnel. Pharmaceuticals 2012, 5, 94-113.
    • (2012) Pharmaceuticals , vol.5 , pp. 94-113
    • Levenson, V.V.1    Melnikov, A.A.2
  • 281
    • 77952519089 scopus 로고    scopus 로고
    • DNA methylation as a universal biomarker
    • Levenson, V.V. DNA methylation as a universal biomarker. Expert Rev. Mol. Diagn. 2010, 10, 481-488.
    • (2010) Expert Rev. Mol. Diagn. , vol.10 , pp. 481-488
    • Levenson, V.V.1
  • 284
    • 84858164821 scopus 로고    scopus 로고
    • Placental 11-beta hydroxysteroid dehydrogenase methylation is associated with newborn growth and a measure of neurobehavioral outcome
    • Marsit, C.J.; Maccani, M.A.; Padbury, J.F.; Lester, B.M. Placental 11-beta hydroxysteroid dehydrogenase methylation is associated with newborn growth and a measure of neurobehavioral outcome. PLoS One 2012, 7, e33794.
    • (2012) PLoS One , vol.7
    • Marsit, C.J.1    McCani, M.A.2    Padbury, J.F.3    Lester, B.M.4
  • 285
    • 84883690085 scopus 로고    scopus 로고
    • Placental miRNA expression profiles are associated with measures of infant neurobehavioral outcomes
    • Maccani, M.A.; Padbury, J.F.; Lester, B.M.; Knopik, V.S.; Marsit, C.J. Placental miRNA expression profiles are associated with measures of infant neurobehavioral outcomes. Pediatr. Res. 2013, 74, 272-278.
    • (2013) Pediatr. Res. , vol.74 , pp. 272-278
    • McCani, M.A.1    Padbury, J.F.2    Lester, B.M.3    Knopik, V.S.4    Marsit, C.J.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.