LINE-1 methylation is associated with an increased risk of ischemic stroke in men

Current Neurovascular Research

Volumn 11, Issue 1, 2014, Pages 4-9

  Lin, Reuy Tay ^a,b   Hsi, Edward ^b,c   Lin, Hsiu Fen ^a,b   Liao, Yi Chu ^d,e   Wang, Yung Song ^b,c   H Juo, Suh Hang ^b,c  

^a KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^b KAOHSIUNG MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^c KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^d TAICHUNG VETERANS GENERAL HOSPITAL   (Taiwan)

^e NATIONAL YANG MING UNIVERSITY   (Taiwan)

Author keywords

DNA Methylation; Ischemic stroke; LINE 1

Indexed keywords

DNA;

ADULT; AGED; ARTICLE; BRAIN ISCHEMIA; CHINESE; CONTROLLED STUDY; CPG ISLAND; DISEASE ASSOCIATION; DNA METHYLATION; FEMALE; HUMAN; LONG INTERSPERSED NUCLEOTIDE ELEMENT 1; LONG INTERSPERSED REPEAT; MAJOR CLINICAL STUDY; MALE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RISK ASSESSMENT;

ADULT; AGED; BLOOD GLUCOSE; BODY MASS INDEX; DNA METHYLATION; FASTING; FEMALE; HUMANS; LONG INTERSPERSED NUCLEOTIDE ELEMENTS; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; SEX CHARACTERISTICS; STROKE; TOMOGRAPHY SCANNERS, X-RAY COMPUTED;

EID: 84898743142     PISSN: 15672026     EISSN: 18755739     Source Type: Journal    
DOI: 10.2174/1567202610666131202145530     Document Type: Article

References (39)

1. Chen RZ, Pettersson U, Beard C, Jackson-Grusby L, Jaenisch R. DNA hypomethylation leads to elevated mutation rates. Nature 1998; 395(6697): 89-93.
2. Ji W, Hernandez R, Zhang XY, et al. DNA demethylation and pericentromeric rearrangements of chromosome 1. Mutat Res 1997; 379(1): 33-41.
3. Lander ES, Linton LM, Birren B, et al. Initial sequencing and analysis of the human genome. Nature 2001; 409(6822): 860-921.
4. Yang AS, Estecio MR, Doshi K, Kondo Y, Tajara EH, Issa JP. A simple method for estimating global DNA methylation using bisulfite PCR of repetitive DNA elements. Nucleic Acids Res 2004; 32(3): e38.
5. Hiltunen MO, Yla-Herttuala S. DNA methylation, smooth muscle cells, and atherogenesis. Arterioscler Thromb Vasc Biol 2003; 23(10): 1750-3.
6. Turunen MP, Aavik E, Yla-Herttuala S. Epigenetics and atherosclerosis. Biochim Biophys Acta 2009; 1790(9): 886-91.
7. Wang YS, Chou WW, Chen KC, Cheng HY, Lin RT, Juo SH. MicroRNA-152 mediates DNMT1-regulated DNA methylation in the estrogen receptor alpha gene. PLoS One 2012; 7(1): e30635.
8. Lund G, Andersson L, Lauria M, et al. DNA methylation polymorphisms precede any histological sign of atherosclerosis in mice lacking apolipoprotein E. J Biol Chem 2004; 279(28): 29147-54.
9. Sharma P, Kumar J, Garg G, et al. Detection of altered global DNA methylation in coronary artery disease patients. DNA Cell Biol 2008; 27(7): 357-65.
10. Kim M, Long TI, Arakawa K, Wang R, Yu MC, Laird PW. DNA methylation as a biomarker for cardiovascular disease risk. PLoS One 2010; 5(3): e9692.
11. Baccarelli A, Wright R, Bollati V, et al. Ischemic heart disease and stroke in relation to blood DNA methylation. Epidemiology 2010; 21(6): 819-28.
12. The World Health Organization MONICA Project (monitoring trends and determinants in cardiovascular disease): a major international collaboration. WHO MONICA Project Principal Investigators. J Clin Epidemiol 1988; 41(2): 105-14.
13. Zhang FF, Cardarelli R, Carroll J, et al. Significant differences in global genomic DNA methylation by gender and race/ethnicity in peripheral blood. Epigenetics 2011; 6(5): 623-9.
14. Subramanyam MA, Diez-Roux AV, Pilsner JR, et al. Social factors and leukocyte DNA methylation of repetitive sequences: the multiethnic study of atherosclerosis. PLoS One 2013; 8(1): e54018.
15. Cash HL, McGarvey ST, Houseman EA, et al. Cardiovascular disease risk factors and DNA methylation at the LINE-1 repeat region in peripheral blood from Samoan Islanders. Epigenetics 2011; 6(10): 1257-64.
16. Pelisek J, Culmes M, Dushenalieva S, Napieralski R, Schmitt M, Eckstein HH. DNA and histone methylation in atherosclerotic lesions of carotid arteries. Cerebrovasc Dis 2011; 31 (suppl 1): 1-74.
17. Lucchinetti E, Feng J, Silva R, et al. Inhibition of LINE-1 expression in the heart decreases ischemic damage by activation of Akt/PKB signaling. Physiol Genomics 2006; 25(2): 314-24.
18. Belancio VP, Roy-Engel AM, Pochampally RR, Deininger P. Somatic expression of LINE-1 elements in human tissues. Nucleic Acids Res 2010; 38(12): 3909-22.
19. Baccarelli A, Tarantini L, Wright RO, et al. Repetitive element DNA methylation and circulating endothelial and inflammation markers in the VA normative aging study. Epigenetics 2010; 5(3): 222-28.
20. Qureshi IA, Mehler MF. Emerging role of epigenetics in stroke: part 1: DNA methylation and chromatin modifications. Arch Neurol 2010; 67(11): 1316-22.
21. Kelly PJ, Rosand J, Kistler JP, et al. Homocysteine, MTHFR 677C->T polymorphism, and risk of ischemic stroke: results of a meta-analysis. Neurology 2002; 59(4): 529-36.
22. Kim JM, Stewart R, Park MS, et al. Associations of BDNF genotype and promoter methylation with acute and long-term stroke outcomes in an East Asian cohort. PLoS One 2012; 7(12): e51280.
23. Hu CJ, Chen SD, Yang DI, et al. Promoter region methylation and reduced expression of thrombospondin-1 after oxygen-glucose deprivation in murine cerebral endothelial cells. J Cereb Blood Flow Metab 2006; 26(12): 1519-26.
24. Jakopovic M, Thomas A, Balasubramaniam S, Schrump D, Giaccone G, Bates SE. Targeting the Epigenome in Lung Cancer: Expanding Approaches to Epigenetic Therapy. Front Oncol 2013; 3: 261.
25. Lao VV, Grady WM. Epigenetics and colorectal cancer. Nat Rev Gastroenterol Hepatol 2011; 8(12): 686-700.
26. Takahashi S. Epigenetic aberrations in myeloid malignancies (Review). Int J Mol Med 2013; 32(3): 532-8.
27. Issa JP. The myelodysplastic syndrome as a prototypical epigenetic disease. Blood 2013; 121(19): 3811-7.
28. Weller M, Pfister SM, Wick W, Hegi ME, Reifenberger G, Stupp R. Molecular neuro-oncology in clinical practice: a new horizon. Lancet Oncol 2013; 14(9): e370-9.
29. Van De Voorde L, Speeckaert R, Van Gestel D, et al. DNA methylation-based biomarkers in serum of patients with breast cancer. Mutat Res 2012; 751(2): 304-25.
30. Rodriguez-Paredes M, Esteller M. Cancer epigenetics reaches mainstream oncology. Nat Med 2011; 17(3): 330-9.
31. Mahgoub M, Monteggia LM. Epigenetics and Psychiatry. Neurotherapeutics 2013; 10(4): 734-41.
32. Zovkic IB, Sweatt JD. Epigenetic mechanisms in learned fear: implications for PTSD. Neuropsychopharmacology 2013; 38(1): 77-93.
33. Bottini N, Firestein GS. Epigenetics in rheumatoid arthritis: a primer for rheumatologists. Curr Rheumatol Rep 2013; 15(11): 372.
34. Ballestar E. Epigenetic alterations in autoimmune rheumatic diseases. Nat Rev Rheumatol 2011; 7(5): 263-71.
35. Devries A, Vercelli D. Epigenetics of human asthma and allergy: promises to keep. Asian Pac J Allergy Immunol 2013; 31(3): 183-9.
36. Karmaus W, Ziyab AH, Everson T, Holloway JW. Epigenetic mechanisms and models in the origins of asthma. Curr Opin Allergy Clin Immunol 2013; 13(1): 63-9.
37. Chouliaras L, Rutten BP, Kenis G, et al. Epigenetic regulation in the pathophysiology of Alzheimer's disease. Prog Neurobiol 2010; 90(4): 498-510.
38. Masliah E, Dumaop W, Galasko D, Desplats P. Distinctive patterns of DNA methylation associated with Parkinson disease: Identification of concordant epigenetic changes in brain and peripheral blood leukocytes. Epigenetics 2013; 8(10): 1030-8.
39. Terry MB, Delgado-Cruzata L, Vin-Raviv N, Wu HC, Santella RM. DNA methylation in white blood cells: association with risk factors in epidemiologic studies. Epigenetics 2011; 6(7): 828-37.