-
1
-
-
39349096526
-
Hematopoiesis: An evolving paradigm for stem cell biology
-
Orkin SH, Zon LI. Hematopoiesis: an evolving paradigm for stem cell biology. Cell. 2008;132(4): 631-644.
-
(2008)
Cell
, vol.132
, Issue.4
, pp. 631-644
-
-
Orkin, S.H.1
Zon, L.I.2
-
2
-
-
38349132624
-
Deconstructing stem cell self-renewal: Genetic insights into cell-cycle regulation
-
Orford KW, Scadden DT. Deconstructing stem cell self-renewal: genetic insights into cell-cycle regulation. Nat Rev Genet. 2008;9(2):115-128.
-
(2008)
Nat Rev Genet.
, vol.9
, Issue.2
, pp. 115-128
-
-
Orford, K.W.1
Scadden, D.T.2
-
3
-
-
0037023528
-
HOXB4-induced expansion of adult hematopoietic stem cells ex vivo
-
Antonchuk J, Sauvageau G, Humphries RK. HOXB4-induced expansion of adult hematopoietic stem cells ex vivo. Cell. 2002;109(1):39-45.
-
(2002)
Cell
, vol.109
, Issue.1
, pp. 39-45
-
-
Antonchuk, J.1
Sauvageau, G.2
Humphries, R.K.3
-
4
-
-
2542467750
-
Hoxb4-deficient mice undergo normal hematopoietic development but exhibit a mild proliferation defect in hematopoietic stem cells
-
Brun AC, Björnsson JM, Magnusson M, et al. Hoxb4-deficient mice undergo normal hematopoietic development but exhibit a mild proliferation defect in hematopoietic stem cells. Blood. 2004;103(11):4126-4133.
-
(2004)
Blood
, vol.103
, Issue.11
, pp. 4126-4133
-
-
Brun, A.C.1
Björnsson, J.M.2
Magnusson, M.3
-
5
-
-
27844485675
-
Notch and Wnt inhibitors as potential new drugs for intestinal neoplastic disease
-
van Es JH, Clevers H. Notch and Wnt inhibitors as potential new drugs for intestinal neoplastic disease. Trends Mol Med. 2005;11(11):496-502.
-
(2005)
Trends Mol Med.
, vol.11
, Issue.11
, pp. 496-502
-
-
Van Es, J.H.1
Clevers, H.2
-
6
-
-
10344258563
-
Enhanced self-renewal of hematopoietic stem cells mediated by the polycomb gene product Bmi-1
-
Iwama A, Oguro H, Negishi M, et al. Enhanced self-renewal of hematopoietic stem cells mediated by the polycomb gene product Bmi-1. Immunity. 2004;21(6):843-851.
-
(2004)
Immunity
, vol.21
, Issue.6
, pp. 843-851
-
-
Iwama, A.1
Oguro, H.2
Negishi, M.3
-
7
-
-
0037673984
-
Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells
-
Lessard J, Sauvageau G. Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells. Nature. 2003;423(6937):255-260.
-
(2003)
Nature
, vol.423
, Issue.6937
, pp. 255-260
-
-
Lessard, J.1
Sauvageau, G.2
-
8
-
-
0038349957
-
Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells
-
Park IK, Qian D, Kiel M, et al. Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells. Nature. 2003; 423(6937):302-305.
-
(2003)
Nature
, vol.423
, Issue.6937
, pp. 302-305
-
-
Park, I.K.1
Qian, D.2
Kiel, M.3
-
9
-
-
8144220648
-
Transcription factor Gfi1 regulates self-renewal and engraftment of hematopoietic stem cells
-
Zeng H, Yücel R, Kosan C, Klein-Hitpass L, Möröy T. Transcription factor Gfi1 regulates self-renewal and engraftment of hematopoietic stem cells. EMBO J. 2004;23(20):4116-4125.
-
(2004)
EMBO J.
, vol.23
, Issue.20
, pp. 4116-4125
-
-
Zeng, H.1
Yücel, R.2
Kosan, C.3
Klein-Hitpass, L.4
Möröy, T.5
-
10
-
-
7244231429
-
Gfi-1 restricts proliferation and preserves functional integrity of haematopoietic stem cells
-
Hock H, Hamblen MJ, Rooke HM, et al. Gfi-1 restricts proliferation and preserves functional integrity of haematopoietic stem cells. Nature. 2004;431(7011):1002-1007.
-
(2004)
Nature
, vol.431
, Issue.7011
, pp. 1002-1007
-
-
Hock, H.1
Hamblen, M.J.2
Rooke, H.M.3
-
11
-
-
70350654370
-
DNA methylation protects hematopoietic stem cell multipotency from myeloerythroid restriction
-
Bröske AM, Vockentanz L, Kharazi S, et al. DNA methylation protects hematopoietic stem cell multipotency from myeloerythroid restriction. Nat Genet. 2009;41(11):1207-1215.
-
(2009)
Nat Genet.
, vol.41
, Issue.11
, pp. 1207-1215
-
-
Bröske, A.M.1
Vockentanz, L.2
Kharazi, S.3
-
12
-
-
70349469788
-
DNA methyltransferase 1 is essential for and uniquely regulates hematopoietic stem and progenitor cells
-
Trowbridge JJ, Snow JW, Kim J, Orkin SH. DNA methyltransferase 1 is essential for and uniquely regulates hematopoietic stem and progenitor cells. Cell Stem Cell. 2009;5(4):442-449.
-
(2009)
Cell Stem Cell
, vol.5
, Issue.4
, pp. 442-449
-
-
Trowbridge, J.J.1
Snow, J.W.2
Kim, J.3
Orkin, S.H.4
-
13
-
-
0037069424
-
Distinct roles for CREBbinding protein and p300 in hematopoietic stem cell self-renewal
-
Rebel VI, Kung AL, Tanner EA, Yang H, Bronson RT, Livingston DM. Distinct roles for CREBbinding protein and p300 in hematopoietic stem cell self-renewal. Proc Natl Acad Sci USA. 2002; 99(23):14789-14794.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, Issue.23
, pp. 14789-14794
-
-
Rebel, V.I.1
Kung, A.L.2
Tanner, E.A.3
Yang, H.4
Bronson, R.T.5
Livingston, D.M.6
-
14
-
-
43249083123
-
The role of the chromatin remodeler Mi-2beta in hematopoietic stem cell self-renewal and multilineage differentiation
-
Yoshida T, Hazan I, Zhang J, et al. The role of the chromatin remodeler Mi-2beta in hematopoietic stem cell self-renewal and multilineage differentiation. Genes Dev. 2008;22(9): 1174-1189.
-
(2008)
Genes Dev.
, vol.22
, Issue.9
, pp. 1174-1189
-
-
Yoshida, T.1
Hazan, I.2
Zhang, J.3
-
15
-
-
7244234099
-
Role of histone H2A ubiquitination in Polycomb silencing
-
Wang H, Wang L, Erdjument-Bromage H, et al. Role of histone H2A ubiquitination in Polycomb silencing. Nature. 2004;431(7010):873-878.
-
(2004)
Nature
, vol.431
, Issue.7010
, pp. 873-878
-
-
Wang, H.1
Wang, L.2
Erdjument-Bromage, H.3
-
16
-
-
29144487990
-
Role of Bmi-1 and Ring1A in H2A ubiquitylation and Hox gene silencing
-
Cao R, Tsukada Y, Zhang Y. Role of Bmi-1 and Ring1A in H2A ubiquitylation and Hox gene silencing. Mol Cell. 2005;20(6):845-854.
-
(2005)
Mol Cell
, vol.20
, Issue.6
, pp. 845-854
-
-
Cao, R.1
Tsukada, Y.2
Zhang, Y.3
-
17
-
-
38549106607
-
Inactivation of the polycomb group protein Ring1B unveils an antiproliferative role in hematopoietic cell expansion and cooperation with tumorigenesis associated with Ink4a deletion
-
Calés C, Román-Trufero M, Pavón L, et al. Inactivation of the polycomb group protein Ring1B unveils an antiproliferative role in hematopoietic cell expansion and cooperation with tumorigenesis associated with Ink4a deletion. Mol Cell Biol. 2008;28(3):1018-1028.
-
(2008)
Mol Cell Biol.
, vol.28
, Issue.3
, pp. 1018-1028
-
-
Calés, C.1
Román-Trufero, M.2
Pavón, L.3
-
18
-
-
0037128662
-
Polycomb group gene rae28 is required for sustaining activity of hematopoietic stem cells
-
Ohta H, Sawada A, Kim JY, et al. Polycomb group gene rae28 is required for sustaining activity of hematopoietic stem cells. J Exp Med. 2002; 195(6):759-770.
-
(2002)
J Exp Med.
, vol.195
, Issue.6
, pp. 759-770
-
-
Ohta, H.1
Sawada, A.2
Kim, J.Y.3
-
19
-
-
0030849638
-
The role of mel-18, a mammalian Polycomb group gene, during IL-7-dependent proliferation of lymphocyte precursors
-
Akasaka T, Tsuji K, Kawahira H, et al. The role of mel-18, a mammalian Polycomb group gene, during IL-7-dependent proliferation of lymphocyte precursors. Immunity. 1997;7(1):135-146.
-
(1997)
Immunity
, vol.7
, Issue.1
, pp. 135-146
-
-
Akasaka, T.1
Tsuji, K.2
Kawahira, H.3
-
20
-
-
7744228427
-
Polycomb group proteins Ring1A/B link ubiquitylation of histone H2A to heritable gene silencing and X inactivation
-
de Napoles M, Mermoud JE, Wakao R, et al. Polycomb group proteins Ring1A/B link ubiquitylation of histone H2A to heritable gene silencing and X inactivation. Dev Cell. 2004;7(5): 663-676.
-
(2004)
Dev Cell
, vol.7
, Issue.5
, pp. 663-676
-
-
De Napoles, M.1
Mermoud, J.E.2
Wakao, R.3
-
21
-
-
38149081168
-
Deubiquitylation of histone H2A activates transcriptional initiation via trans-histone crosstalk with H3K4 di- and trimethylation
-
Nakagawa T, Kajitani T, Togo S, et al. Deubiquitylation of histone H2A activates transcriptional initiation via trans-histone crosstalk with H3K4 di- and trimethylation. Genes Dev. 2008;22(1):37-49.
-
(2008)
Genes Dev.
, vol.22
, Issue.1
, pp. 37-49
-
-
Nakagawa, T.1
Kajitani, T.2
Togo, S.3
-
22
-
-
36749089980
-
Ring1-mediated ubiquitination of H2A restrains poised RNA polymerase II at bivalent genes in mouse ES cells
-
Stock JK, Giadrossi S, Casanova M, et al. Ring1-mediated ubiquitination of H2A restrains poised RNA polymerase II at bivalent genes in mouse ES cells. Nat Cell Biol. 2007;9(12):1428-1435.
-
(2007)
Nat Cell Biol.
, vol.9
, Issue.12
, pp. 1428-1435
-
-
Stock, J.K.1
Giadrossi, S.2
Casanova, M.3
-
23
-
-
38149098408
-
Histone H2A monoubiquitination represses transcription by inhibiting RNA polymerase II transcriptional elongation
-
Zhou W, Zhu P, Wang J, et al. Histone H2A monoubiquitination represses transcription by inhibiting RNA polymerase II transcriptional elongation. Mol Cell. 2008;29(1):69-80.
-
(2008)
Mol Cell
, vol.29
, Issue.1
, pp. 69-80
-
-
Zhou, W.1
Zhu, P.2
Wang, J.3
-
24
-
-
77951947926
-
Ring1B compacts chromatin structure and represses gene expression independent of histone ubiquitination
-
Eskeland R, Leeb M, Grimes GR, et al. Ring1B compacts chromatin structure and represses gene expression independent of histone ubiquitination. Mol Cell. 2010;38(3):452-464.
-
(2010)
Mol Cell
, vol.38
, Issue.3
, pp. 452-464
-
-
Eskeland, R.1
Leeb, M.2
Grimes, G.R.3
-
25
-
-
84864585700
-
Histone H2A mono-ubiquitination is a crucial step to mediate PRC1-dependent repression of developmental genes to maintain ES cell identity
-
Endoh M, Endo TA, Endoh T, et al. Histone H2A mono-ubiquitination is a crucial step to mediate PRC1-dependent repression of developmental genes to maintain ES cell identity. PLoS Genet. 2012;8(7):e1002774.
-
(2012)
PLoS Genet.
, vol.8
, Issue.7
, pp. e1002774
-
-
Endoh, M.1
Endo, T.A.2
Endoh, T.3
-
26
-
-
35548986309
-
Regulation of cell cycle progression and gene expression by H2A deubiquitination
-
Joo HY, Zhai L, Yang C, et al. Regulation of cell cycle progression and gene expression by H2A deubiquitination. Nature. 2007;449(7165): 1068-1072.
-
(2007)
Nature
, vol.449
, Issue.7165
, pp. 1068-1072
-
-
Joo, H.Y.1
Zhai, L.2
Yang, C.3
-
27
-
-
77952429798
-
Histone H2A deubiquitinase activity of the Polycomb repressive complex PR-DUB
-
Scheuermann JC, de Ayala Alonso AG, Oktaba K, et al. Histone H2A deubiquitinase activity of the Polycomb repressive complex PR-DUB. Nature. 2010;465(7295):243-247.
-
(2010)
Nature
, vol.465
, Issue.7295
, pp. 243-247
-
-
Scheuermann, J.C.1
De Ayala-Alonso, A.G.2
Oktaba, K.3
-
28
-
-
34547730282
-
A histone H2A deubiquitinase complex coordinating histone acetylation and H1 dissociation in transcriptional regulation
-
Zhu P, Zhou W, Wang J, et al. A histone H2A deubiquitinase complex coordinating histone acetylation and H1 dissociation in transcriptional regulation. Mol Cell. 2007;27(4):609-621.
-
(2007)
Mol Cell
, vol.27
, Issue.4
, pp. 609-621
-
-
Zhu, P.1
Zhou, W.2
Wang, J.3
-
29
-
-
77953720192
-
ATM-dependent chromatin changes silence transcription in cis to DNA double-strand breaks
-
Shanbhag NM, Rafalska-Metcalf IU, Balane-Bolivar C, Janicki SM, Greenberg RA. ATM-dependent chromatin changes silence transcription in cis to DNA double-strand breaks. Cell. 2010;141(6):970-981.
-
(2010)
Cell
, vol.141
, Issue.6
, pp. 970-981
-
-
Shanbhag, N.M.1
Rafalska-Metcalf, I.U.2
Balane-Bolivar, C.3
Janicki, S.M.4
Greenberg, R.A.5
-
30
-
-
33746407708
-
Recruitment of PRC1 function at the initiation of X inactivation independent of PRC2 and silencing
-
Schoeftner S, Sengupta AK, Kubicek S, et al. Recruitment of PRC1 function at the initiation of X inactivation independent of PRC2 and silencing. EMBO J. 2006;25(13):3110-3122.
-
(2006)
EMBO J.
, vol.25
, Issue.13
, pp. 3110-3122
-
-
Schoeftner, S.1
Sengupta, A.K.2
Kubicek, S.3
-
31
-
-
84255174663
-
Control of B cell development by the histone H2A deubiquitinase MYSM1
-
Jiang XX, Nguyen Q, Chou Y, et al. Control of B cell development by the histone H2A deubiquitinase MYSM1. Immunity. 2011;35(6): 883-896.
-
(2011)
Immunity
, vol.35
, Issue.6
, pp. 883-896
-
-
Jiang, X.X.1
Nguyen, Q.2
Chou, Y.3
-
32
-
-
84863393730
-
The critical role of histone H2Adeubiquitinase Mysm1 in hematopoiesis and lymphocyte differentiation
-
Sanger Institute Microarray Facility
-
Nijnik A, Clare S, Hale C, et al; Sanger Institute Microarray Facility; Sanger Mouse Genetics Project. The critical role of histone H2Adeubiquitinase Mysm1 in hematopoiesis and lymphocyte differentiation. Blood. 2012; 119(6):1370-1379.
-
(2012)
Blood
, vol.119
, Issue.6
, pp. 1370-1379
-
-
Nijnik, A.1
Clare, S.2
Hale, C.3
-
33
-
-
56549128268
-
Hematopoietic stem cells reversibly switch from dormancy to self-renewal during homeostasis and repair
-
Wilson A, Laurenti E, Oser G, et al. Hematopoietic stem cells reversibly switch from dormancy to self-renewal during homeostasis and repair. Cell. 2008;135(6):1118-1129.
-
(2008)
Cell
, vol.135
, Issue.6
, pp. 1118-1129
-
-
Wilson, A.1
Laurenti, E.2
Oser, G.3
-
34
-
-
79955028943
-
The E3 ligase Itch is a negative regulator of the homeostasis and function of hematopoietic stem cells
-
Rathinam C, Matesic LE, Flavell RA. The E3 ligase Itch is a negative regulator of the homeostasis and function of hematopoietic stem cells. Nat Immunol. 2011;12(5):399-407.
-
(2011)
Nat Immunol.
, vol.12
, Issue.5
, pp. 399-407
-
-
Rathinam, C.1
Matesic, L.E.2
Flavell, R.A.3
-
35
-
-
0034749999
-
Upregulation of Flt3 expression within the bone marrow Lin(2)Sca1(1)c-kit(1) stem cell compartment is accompanied by loss of selfrenewal capacity
-
Adolfsson J, Borge OJ, Bryder D, et al. Upregulation of Flt3 expression within the bone marrow Lin(2)Sca1(1)c-kit(1) stem cell compartment is accompanied by loss of selfrenewal capacity. Immunity. 2001;15(4):659-669.
-
(2001)
Immunity
, vol.15
, Issue.4
, pp. 659-669
-
-
Adolfsson, J.1
Borge, O.J.2
Bryder, D.3
-
36
-
-
84868310511
-
The Notch pathway in hematopoietic stem cells
-
Radtke F, ed. Berlin, Heidelberg: Springer
-
Bigas A, D'Altri T, Espinosa L. The Notch pathway in hematopoietic stem cells. In: Radtke F, ed. Notch Regulation of the Immune System. Vol. 360. Berlin, Heidelberg: Springer; 2012:1-18.
-
(2012)
Notch Regulation of the Immune System
, vol.360
, pp. 1-18
-
-
Bigas, A.1
D'Altri, T.2
Espinosa, L.3
-
37
-
-
0037687417
-
Targets of the transcriptional repressor oncoprotein Gfi-1
-
Duan Z, Horwitz M. Targets of the transcriptional repressor oncoprotein Gfi-1. Proc Natl Acad Sci USA. 2003;100(10):5932-5937.
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, Issue.10
, pp. 5932-5937
-
-
Duan, Z.1
Horwitz, M.2
-
38
-
-
13244252714
-
Gfi-1 takes center stage in hematopoietic stem cells
-
Duan Z, Horwitz M. Gfi-1 takes center stage in hematopoietic stem cells. Trends Mol Med. 2005; 11(2):49-52.
-
(2005)
Trends Mol Med.
, vol.11
, Issue.2
, pp. 49-52
-
-
Duan, Z.1
Horwitz, M.2
-
39
-
-
79952138371
-
Growth factor independence 1 protects hematopoietic stem cells against apoptosis but also prevents the development of a myeloproliferative-like disease
-
Khandanpour C, Kosan C, Gaudreau MC, et al. Growth factor independence 1 protects hematopoietic stem cells against apoptosis but also prevents the development of a myeloproliferative-like disease. Stem Cells. 2011;29(2):376-385.
-
(2011)
Stem Cells
, vol.29
, Issue.2
, pp. 376-385
-
-
Khandanpour, C.1
Kosan, C.2
Gaudreau, M.C.3
-
40
-
-
77955298571
-
Gfi1 expression is controlled by five distinct regulatory regions spread over 100 kilobases, with Scl/Tal1, Gata2, PU.1, Erg, Meis1, and Runx1 acting as upstream regulators in early hematopoietic cells
-
Wilson NK, Timms RT, Kinston SJ, et al. Gfi1 expression is controlled by five distinct regulatory regions spread over 100 kilobases, with Scl/Tal1, Gata2, PU.1, Erg, Meis1, and Runx1 acting as upstream regulators in early hematopoietic cells. Mol Cell Biol. 2010;30(15):3853-3863.
-
(2010)
Mol Cell Biol.
, vol.30
, Issue.15
, pp. 3853-3863
-
-
Wilson, N.K.1
Timms, R.T.2
Kinston, S.J.3
-
41
-
-
34249295972
-
Cooperative interaction between ETS1 and GFI1 transcription factors in the repression of Bax gene expression
-
Nakazawa Y, Suzuki M, Manabe N, et al. Cooperative interaction between ETS1 and GFI1 transcription factors in the repression of Bax gene expression. Oncogene. 2007;26(24): 3541-3550.
-
(2007)
Oncogene
, vol.26
, Issue.24
, pp. 3541-3550
-
-
Nakazawa, Y.1
Suzuki, M.2
Manabe, N.3
-
42
-
-
71849114718
-
Balancing dormant and self-renewing hematopoietic stem cells
-
Wilson A, Laurenti E, Trumpp A. Balancing dormant and self-renewing hematopoietic stem cells. Curr Opin Genet Dev. 2009;19(5): 461-468.
-
(2009)
Curr Opin Genet Dev.
, vol.19
, Issue.5
, pp. 461-468
-
-
Wilson, A.1
Laurenti, E.2
Trumpp, A.3
-
43
-
-
77649119006
-
Awakening dormant haematopoietic stem cells
-
Trumpp A, Essers M, Wilson A. Awakening dormant haematopoietic stem cells. Nat Rev Immunol. 2010;10(3):201-209.
-
(2010)
Nat Rev Immunol.
, vol.10
, Issue.3
, pp. 201-209
-
-
Trumpp, A.1
Essers, M.2
Wilson, A.3
-
44
-
-
42149188212
-
The E3 ubiquitin ligase c-Cbl restricts development and functions of hematopoietic stem cells
-
Rathinam C, Thien CB, Langdon WY, Gu H, Flavell RA. The E3 ubiquitin ligase c-Cbl restricts development and functions of hematopoietic stem cells. Genes Dev. 2008;22(8):992-997.
-
(2008)
Genes Dev.
, vol.22
, Issue.8
, pp. 992-997
-
-
Rathinam, C.1
Thien, C.B.2
Langdon, W.Y.3
Gu, H.4
Flavell, R.A.5
-
45
-
-
41449118699
-
The transcription factor EGR1 controls both the proliferation and localization of hematopoietic stem cells
-
Min IM, Pietramaggiori G, Kim FS, Passegué E, Stevenson KE, Wagers AJ. The transcription factor EGR1 controls both the proliferation and localization of hematopoietic stem cells. Cell Stem Cell. 2008;2(4):380-391.
-
(2008)
Cell Stem Cell
, vol.2
, Issue.4
, pp. 380-391
-
-
Min, I.M.1
Pietramaggiori, G.2
Kim, F.S.3
Passegué, E.4
Stevenson, K.E.5
Wagers, A.J.6
|