Identification of CpG-SNPs associated with type 2 diabetes and differential DNA methylation in human pancreatic islets

Diabetologia

Volumn 56, Issue 5, 2013, Pages 1036-1046

  Dayeh, T A ^a   Olsson, A H ^a   Volkov, P ^a   Almgren, P ^a   Ronn T ^a   Ling, C ^a  

^a LUND UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Alternative splicing; CpG SNP; DNA methylation; Epigenetics; Glucagon; Human pancreatic islets; Insulin secretion; SNP; Splice index; Type 2 diabetes

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 2A; DNA; HEMOGLOBIN A1C; HIGH MOBILITY GROUP A2 PROTEIN; INSULIN RECEPTOR SUBSTRATE 1; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; POTASSIUM CHANNEL KCNQ1; TRANSCRIPTION FACTOR 7 LIKE 2;

ADCY5 GENE; ADULT; ALTERNATIVE RNA SPLICING; ARTICLE; CDKAL1 GENE; CDKN2A GENE; CHCHD9 GENE; CPG ISLAND; DNA METHYLATION; DUSP8 GENE; DUSP9 GENE; FEMALE; GENE; GENE EXPRESSION; GENE FUNCTION; GENE LINKAGE DISEQUILIBRIUM; GENE LOCUS; GENETIC ASSOCIATION; GENETIC PARAMETERS; HHEX GENE; HMGA2 GENE; HORMONE RELEASE; HUMAN; HUMAN CELL; IRS1 GENE; KCNQ1 GENE; MAJOR CLINICAL STUDY; MALE; MOLECULAR PATHOLOGY; NON INSULIN DEPENDENT DIABETES MELLITUS; PANCREAS ISLET; PHENOTYPE; PPARG GENE; PRIORITY JOURNAL; PYROSEQUENCING; SINGLE NUCLEOTIDE POLYMORPHISM; SLC30A8 GENE; SPLICE INDEX; SRR GENE; TCF7L2 GENE; TSPAN8 GENE; WFS1 GENE;

AGED; ALTERNATIVE SPLICING; COHORT STUDIES; CPG ISLANDS; DIABETES MELLITUS, TYPE 2; DNA METHYLATION; EPIGENESIS, GENETIC; FEMALE; GENE EXPRESSION REGULATION; GENETIC ASSOCIATION STUDIES; HUMANS; INSULIN; ISLETS OF LANGERHANS; LINKAGE DISEQUILIBRIUM; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; RNA, MESSENGER; SCANDINAVIA; TISSUE CULTURE TECHNIQUES; TISSUE DONORS;

EID: 84876458561     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-012-2815-7     Document Type: Article

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