Vitamin C induces Tet-dependent DNA demethylation and a blastocyst-like state in ES cells

Nature

Volumn 500, Issue 7461, 2013, Pages 222-226

  Blaschke, Kathryn ^a   Ebata, Kevin T ^a   Karimi, Mohammad M ^b,c   Zepeda Martínez, Jorge A ^d   Goyal, Preeti ^b   Mahapatra, Sahasransu ^d   Tam, Angela ^c   Laird, Diana J ^a   Hirst, Martin ^b,c   Rao, Anjana ^d   Lorincz, Matthew C ^b   Ramalho Santos, Miguel ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^c BRITISH COLUMBIA CANCER AGENCY   (Canada)

^d LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 HYDROXYMETHYLCYTOSINE; 5 METHYLCYTOSINE; ASCORBIC ACID; DNA FRAGMENT; ENZYME; GLUTATHIONE PEROXIDASE 2; TEN ELEVEN TRANSLOCATION ENZYME; TEN ELEVEN TRANSLOCATION ENZYME 1; TEN ELEVEN TRANSLOCATION ENZYME 2; TEN ELEVEN TRANSLOCATION ENZYME 3; UNCLASSIFIED DRUG;

ASCORBIC ACID; BIOASSAY; DNA; EMBRYO; GENE EXPRESSION; IMPRINTING; METHYLATION;

ARTICLE; BLASTOCYST; DNA METHYLATION; EMBRYONIC STEM CELL; ENZYME ACTIVITY; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; PRIORITY JOURNAL; PROMOTER REGION; TRANSCRIPTION INITIATION SITE; UPREGULATION;

ANIMALS; ANTIOXIDANTS; ASCORBIC ACID; BLASTOCYST; CELL LINE; CULTURE MEDIA; CYTOSINE; DNA METHYLATION; DNA-BINDING PROTEINS; EMBRYONIC STEM CELLS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENE KNOCKOUT TECHNIQUES; MICE; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS; RECOMBINANT PROTEINS;

INTRACISTERNAL A-PARTICLES;

EID: 84881476916     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature12362     Document Type: Article

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