Cardiovascular epigenetics: From DNA methylation to microRNAs

Molecular Aspects of Medicine

Volumn 34, Issue 4, 2013, Pages 883-901

  Udali, Silvia ^a   Guarini, Patrizia ^a   Moruzzi, Sara ^a   Choi, Sang Woon ^b   Friso, Simonetta ^a  

^a UNIVERSITY OF VERONA   (Italy)

^b TUFTS UNIVERSITY   (United States)

Author keywords

Cardiovascular disease; Coronary artery disease; DNA methylation; Epigenetics; Gene nutrient interactions; Heart failure; Histone modifications; Hypertension; MicroRNA; Nutritional epigenetics; Stroke

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE 2; ARACHIDONATE 15 LIPOXYGENASE; BLOOD CLOTTING FACTOR 7; BLOOD CLOTTING FACTOR 7A; DIPEPTIDYL CARBOXYPEPTIDASE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; MICRORNA; MICRORNA 1; MICRORNA 126; MICRORNA 133A; MICRORNA 134; MICRORNA 145; MICRORNA 17; MICRORNA 198; MICRORNA 208; MICRORNA 208A; MICRORNA 21; MICRORNA 340; MICRORNA 370; MICRORNA 499; MICRORNA 624; MICRORNA 92A; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; RNA; SODIUM POTASSIUM CHLORIDE COTRANSPORTER; THROMBOSPONDIN 1; UNCLASSIFIED DRUG;

11BETA HYDROXYSTEROID DEHYDROGENASE 2 GENE; ANGIOMOTIN LIKE 2 GENE; ARACHIDONATE 15 LIPOXYGENASE GENE; BLOOD CLOTTING FACTOR 7 GENE; BLOOD CLOTTING FACTOR 7A GENE; CARDIOVASCULAR DISEASE; CD31 ANTIGEN GENE; CEREBROVASCULAR ACCIDENT; CONGESTIVE HEART FAILURE; CORONARY ARTERY DISEASE; DNA METHYLATION; ENDOTHELIAL NITRIC OXIDE SYNTHASE GENE; EPIGENETICS; ESTROGEN RECEPTOR ALPHA GENE; ESTROGEN RECEPTOR BETA GENE; GENE EXPRESSION REGULATION; GENE FUNCTION; HEART FAILURE; HEART INFARCTION; HISTONE MODIFICATION; HUMAN; HYPERTENSION; NKCC1 GENE; NONHUMAN; NUTRITIONAL HEALTH; REVIEW; RHO GTPASE ACTIVATING PROTEIN 24 GENE; SOMATIC ANGIOTENSIN CONVERTING ENZYME GENE; THROMBOSPONDIN 1 GENE;

ANIMALS; CARDIOVASCULAR DISEASES; DIET; DNA METHYLATION; EPIGENESIS, GENETIC; GENE-ENVIRONMENT INTERACTION; HISTONES; HUMANS; MICRORNAS; PROTEIN PROCESSING, POST-TRANSLATIONAL;

MAMMALIA;

EID: 84874999809     PISSN: 00982997     EISSN: 18729452     Source Type: Journal    
DOI: 10.1016/j.mam.2012.08.001     Document Type: Review

References (118)

1. T. Adachi, M. Nakanishi, Y. Otsuka, K. Nishimura, G. Hirokawa, Y. Goto, H. Nonogi, and N. Iwai Plasma microRNA 499 as a biomarker of acute myocardial infarction Clin. Chem. 56 7 2010 1183 1185
2. J. Ai, R. Zhang, Y. Li, J. Pu, Y. Lu, J. Jiao, K. Li, B. Yu, Z. Li, R. Wang, L. Wang, Q. Li, N. Wang, H. Shan, and B. Yang Circulating microRNA-1 as a potential novel biomarker for acute myocardial infarction Biochem. Biophys. Res. Commun. 391 1 2010 73 77
3. R. Alikhani-Koopaei, F. Fouladkou, F.J. Frey, and B.M. Frey Epigenetic regulation of 11 beta-hydroxysteroid dehydrogenase type 2 expression J. Clin. Invest. 114 8 2004 1146 1157
4. A. Baccarelli, M. Rienstra, and E.J. Benjamin Cardiovascular epigenetics: basic concepts and results from animal and human studies Circ. Cardiovasc. Genet. 3 6 2010 567 573
5. A. Baccarelli, R. Wright, V. Bollati, A. Litonjua, A. Zanobetti, L. Tarantini, D. Sparrow, P. Vokonas, and J. Schwartz Ischemic heart disease and stroke in relation to blood DNA methylation Epidemiology 21 6 2010 819 828
6. J. Backs, and E.N. Olson Control of cardiac growth by histone acetylation/deacetylation Circ. Res. 98 1 2006 15 24
7. J. Bauersachs, and T. Thum Biogenesis and regulation of cardiovascular microRNAs Circ. Res. 109 3 2011 334 347
8. A. Bird Perceptions of epigenetics Nature 447 7143 2007 396 398
9. E. Birney Chromatin and heritability: how epigenetic studies can complement genetic approaches Trends Genet. 27 5 2011 172 176
10. E. Bostjancic, N. Zidar, D. Stajer, and D. Glavac MicroRNAs miR-1, miR-133a, miR-133b and miR-208 are dysregulated in human myocardial infarction Cardiology 115 3 2010 163 169
11. B. Buller, X. Liu, X. Wang, R.L. Zhang, L. Zhang, A. Hozeska-Solgot, M. Chopp, and Z.G. Zhang MicroRNA-21 protects neurons from ischemic death FEBS J. 277 20 2010 4299 4307
12. R.W. Carthew, and E.J. Sontheimer Origins and Mechanisms of miRNAs and siRNAs Cell 136 4 2009 642 655
13. R. Castro, I. Rivera, E.A. Struys, E.E. Jansen, P. Ravasco, M.E. Camilo, H.J. Blom, C. Jakobs, and I. Tavares de Almeida Increased homocysteine and S-adenosylhomocysteine concentrations and DNA hypomethylation in vascular disease Clin. Chem. 49 8 2003 1292 1296
14. Y. Chan, J.E. Fish, C. D'Abreo, S. Lin, G.B. Robb, A.M. Teichert, F. Karantzoulis-Fegaras, A. Keightley, B.M. Steer, and P.A. Marsden The cell-specific expression of endothelial nitric-oxide synthase: a role for DNA methylation J. Biol. Chem. 279 33 2004 35087 35100
15. J. Chen, T. Yang, H. Yu, K. Sun, Y. Shi, W. Song, Y. Bai, X. Wang, K. Lou, Y. Song, Y. Zhang, and R. Hui A functional variant in the 3′-UTR of angiopoietin-1 might reduce stroke risk by interfering with the binding efficiency of microRNA 211 Hum. Mol. Genet. 19 12 2010 2524 2533
16. Y. Cheng, N. Tan, J. Yang, X. Liu, X. Cao, P. He, X. Dong, S. Qin, and C. Zhang A translational study of circulating cell-free microRNA-1 in acute myocardial infarction Clin. Sci. (Lond.) 119 2 2010 87 95
17. Y. Cheng, and C. Zhang MicroRNA-21 in cardiovascular disease J. Cardiovasc. Transl. Res. 3 3 2010 251 255
18. - cotransporter 1 is epigenetically regulated during postnatal development of hypertension Am. J. Hypertens. 24 12 2011 1286 1293
19. J.H. Choi, K.H. Nam, J. Kim, M.W. Baek, J.E. Park, H.Y. Park, H.J. Kwon, O.S. Kwon, D.Y. Kim, and G.T. Oh Trichostatin A exacerbates atherosclerosis in low density lipoprotein receptor-deficient mice Arterioscler. Thromb. Vasc. Biol. 25 11 2005 2404 2409
20. F. Cipollone, L. Felicioni, R. Sarzani, S. Ucchino, F. Spigonardo, C. Mandolini, S. Malatesta, M. Bucci, C. Mammarella, D. Santovito, F. de Lutiis, A. Marchetti, A. Mezzetti, and F. Buttitta A unique microRNA signature associated with plaque instability in humans Stroke 42 9 2011 2556 2563
21. G. Cirino, S. Fiorucci, and W.C. Sessa Endothelial nitric oxide synthase: the Cinderella of inflammation? Trends Pharmacol. Sci. 24 2 2003 91 95
22. M.F. Corsten, R. Dennert, S. Jochems, T. Kuznetsova, Y. Devaux, L. Hofstra, D.R. Wagner, J.A. Staessen, S. Heymans, and B. Schroen Circulating MicroRNA-208b and MicroRNA-499 reflect myocardial damage in cardiovascular disease Circ. Cardiovasc. Genet. 3 6 2010 499 506
23. E.E. Creemers, A.J. Tijsen, and Y.M. Pinto Circulating microRNAs: novel biomarkers and extracellular communicators in cardiovascular disease? Circ. Res. 110 3 2012 483 495
24. Y. D'Alessandra, P. Devanna, F. Limana, S. Straino, A. Di Carlo, P.G. Brambilla, M. Rubino, M.C. Carena, L. Spazzafumo, M. De Simone, B. Micheli, P. Biglioli, F. Achilli, F. Martelli, S. Maggiolini, G. Marenzi, G. Pompilio, and M.C. Capogrossi Circulating microRNAs are new and sensitive biomarkers of myocardial infarction Eur. Heart J. 31 22 2010 2765 2773
25. S. De Rosa, S. Fichtlscherer, R. Lehmann, B. Assmus, S. Dimmeler, and A.M. Zeiher Transcoronary concentration gradients of circulating microRNAs Circulation 124 18 2011 1936 1944
26. Y. Devaux, M. Vausort, E. Goretti, P.V. Nazarov, F. Azuaje, G. Gilson, M.F. Corsten, B. Schroen, M.L. Lair, S. Heymans, and D.R. Wagner Use of circulating microRNAs to diagnose acute myocardial infarction Clin. Chem. 58 3 2012 559 567
27. A. Dharap, K. Bowen, R. Place, L.C. Li, and R. Vemuganti Transient focal ischemia induces extensive temporal changes in rat cerebral microRNAome J. Cereb. Blood Flow Metab. 29 4 2009 675 687
28. S. Dong, Y. Cheng, J. Yang, J. Li, X. Liu, X. Wang, D. Wang, T.J. Krall, E.S. Delphin, and C. Zhang MicroRNA expression signature and the role of microRNA-21 in the early phase of acute myocardial infarction J. Biol. Chem. 284 43 2009 29514 29525
29. S.J. Duthie Epigenetic modifications and human pathologies: cancer and CVD Proc. Nutr. Soc. 70 1 2011 47 56
30. M. Ehrlich DNA methylation in cancer: too much, but also too little Oncogene 21 35 2002 5400 5413
31. M. Ehrlich Cancer-linked DNA hypomethylation and its relationship to hypermethylation Curr. Top. Microbiol. Immunol. 310 2006 251 274
32. M. Esteller Non-coding RNAs in human disease Nat. Rev. Genet. 12 12 2011 861 874
33. A.P. Feinberg Phenotypic plasticity and the epigenetics of human disease Nature 447 7143 2007 433 440
34. A.P. Feinberg, and B. Tycko The history of cancer epigenetics Nat. Rev. Cancer 4 2 2004 143 153
35. S. Fichtlscherer, S. De Rosa, H. Fox, T. Schwietz, A. Fischer, C. Liebetrau, M. Weber, C.W. Hamm, T. Roxe, M. Muller-Ardogan, A. Bonauer, A.M. Zeiher, and S. Dimmeler Circulating microRNAs in patients with coronary artery disease Circ. Res. 107 5 2010 677 684
36. S. Fichtlscherer, A.M. Zeiher, and S. Dimmeler Circulating microRNAs: biomarkers or mediators of cardiovascular diseases? Arterioscler. Thromb. Vasc. Biol. 31 11 2011 2383 2390
37. J.E. Fish, C.C. Matouk, A. Rachlis, S. Lin, S.C. Tai, C. D'Abreo, and P.A. Marsden The expression of endothelial nitric-oxide synthase is controlled by a cell-specific histone code J. Biol. Chem. 280 26 2005 24824 24838
38. S. Friso, and S.W. Choi Gene-nutrient interactions and DNA methylation J. Nutr. 132 8 Suppl. 2002 2382S 2387S
39. S. Friso, V. Lotto, S.W. Choi, D. Girelli, M. Pinotti, P. Guarini, S. Udali, P. Pattini, F. Pizzolo, N. Martinelli, R. Corrocher, F. Bernardi, and O. Olivieri Promoter methylation in coagulation F7 gene influences plasma FVII concentrations and relates to coronary artery disease J. Med. Genet. 49 3 2012 192 199
40. S. Friso, F. Pizzolo, S.W. Choi, P. Guarini, A. Castagna, V. Ravagnani, A. Carletto, P. Pattini, R. Corrocher, and O. Olivieri Epigenetic control of 11 beta-hydroxysteroid dehydrogenase 2 gene promoter is related to human hypertension Atherosclerosis 199 2 2008 323 327
41. Y. Fukushima, M. Nakanishi, H. Nonogi, Y. Goto, and N. Iwai Assessment of plasma miRNAs in congestive heart failure Circ. J. 75 2 2011 336 340
42. O. Gidlof, P. Andersson, J. van der Pals, M. Gotberg, and D. Erlinge Cardiospecific microRNA plasma levels correlate with troponin and cardiac function in patients with ST elevation myocardial infarction, are selectively dependent on renal elimination, and can be detected in urine samples Cardiology 118 4 2011 217 226
43. D. Girelli, C. Russo, P. Ferraresi, O. Olivieri, M. Pinotti, S. Friso, F. Manzato, A. Mazzucco, F. Bernardi, and R. Corrocher Polymorphisms in the factor VII gene and the risk of myocardial infarction in patients with coronary artery disease N. Engl. J. Med. 343 11 2000 774 780
44. A.D. Goldberg, C.D. Allis, and E. Bernstein Epigenetics: a landscape takes shape Cell 128 4 2007 635 638
45. Y. Goren, M. Kushnir, B. Zafrir, S. Tabak, B.S. Lewis, and O. Amir Serum levels of microRNAs in patients with heart failure Eur. J. Heart Fail. 14 2 2012 147 154
46. D.E. Handy, R. Castro, and J. Loscalzo Epigenetic modifications: basic mechanisms and role in cardiovascular disease Circulation 123 19 2011 2145 2156
47. C.T. Hang, J. Yang, P. Han, H.L. Cheng, C. Shang, E. Ashley, B. Zhou, and C.P. Chang Chromatin regulation by Brg1 underlies heart muscle development and disease Nature 466 7302 2010 62 67
48. B.T. Heijmans, E.W. Tobi, A.D. Stein, H. Putter, G.J. Blauw, E.S. Susser, P.E. Slagboom, and L.H. Lumey Persistent epigenetic differences associated with prenatal exposure to famine in humans Proc. Natl. Acad. Sci. USA 105 44 2008 17046 17049
49. J. Heinrich, L. Balleisen, H. Schulte, G. Assmann, and J. van de Loo Fibrinogen and factor VII in the prediction of coronary risk. Results from the PROCAM study in healthy men Arterioscler. Thromb. 14 1 1994 54 59
50. M.O. Hiltunen, T.T. Tuomisto, M. Niemi, J.H. Brasen, T.T. Rissanen, P. Toronen, I. Vajanto, and S. Yla-Herttuala Changes in gene expression in atherosclerotic plaques analyzed using DNA array Atherosclerosis 165 1 2002 23 32
51. M.O. Hiltunen, M.P. Turunen, T.P. Hakkinen, J. Rutanen, M. Hedman, K. Makinen, A.M. Turunen, K. Aalto-Setala, and S. Yla-Herttuala DNA hypomethylation and methyltransferase expression in atherosclerotic lesions Vasc. Med. 7 1 2002 5 11
52. M. Hoekstra, C.A. van der Lans, B. Halvorsen, L. Gullestad, J. Kuiper, P. Aukrust, T.J. van Berkel, and E.A. Biessen The peripheral blood mononuclear cell microRNA signature of coronary artery disease Biochem. Biophys. Res. Commun. 394 3 2010 792 797
53. C.J. Hu, S.D. Chen, D.I. Yang, T.N. Lin, C.M. Chen, T.H. Huang, and C.Y. Hsu Promoter region methylation and reduced expression of thrombospondin-1 after oxygen-glucose deprivation in murine cerebral endothelial cells J. Cereb. Blood Flow Metab. 26 12 2006 1519 1526
54. S. Ikeda, S.W. Kong, J. Lu, E. Bisping, H. Zhang, P.D. Allen, T.R. Golub, B. Pieske, and W.T. Pu Altered microRNA expression in human heart disease Physiol. Genomics 31 3 2007 367 373
55. T. Jenuwein, and C.D. Allis Translating the histone code Science 293 5532 2001 1074 1080
56. K. Jeyaseelan, K.Y. Lim, and A. Armugam MicroRNA expression in the blood and brain of rats subjected to transient focal ischemia by middle cerebral artery occlusion Stroke 39 3 2008 959 966
57. X. Ji, R. Takahashi, Y. Hiura, G. Hirokawa, Y. Fukushima, and N. Iwai Plasma miR-208 as a biomarker of myocardial injury Clin. Chem. 55 11 2009 1944 1949
58. P.A. Jones DNA methylation and cancer Cancer Res. 46 2 1986 461 466
59. P.A. Jones, and S.B. Baylin The epigenomics of cancer Cell 128 4 2007 683 692
60. P.A. Jones, and P.W. Laird Cancer epigenetics comes of age Nat. Genet. 21 2 1999 163 167
61. P.M. Kearney, M. Whelton, K. Reynolds, P. Muntner, P.K. Whelton, and J. He Global burden of hypertension: analysis of worldwide data Lancet 365 9455 2005 217 223
62. J. Kim, J.Y. Kim, K.S. Song, Y.H. Lee, J.S. Seo, J. Jelinek, P.J. Goldschmidt-Clermont, and J.P. Issa Epigenetic changes in estrogen receptor beta gene in atherosclerotic cardiovascular tissues and in-vitro vascular senescence Biochim. Biophys. Acta 1772 1 2007 72 80
63. M. Kim, T.I. Long, K. Arakawa, R. Wang, M.C. Yu, and P.W. Laird DNA methylation as a biomarker for cardiovascular disease risk PLoS One 5 3 2010 e9692
64. O.F. Laterza, L. Lim, P.W. Garrett-Engele, K. Vlasakova, N. Muniappa, W.K. Tanaka, J.M. Johnson, J.F. Sina, T.L. Fare, F.D. Sistare, and W.E. Glaab Plasma MicroRNAs as sensitive and specific biomarkers of tissue injury Clin. Chem. 55 11 2009 1977 1983
65. M.O. Laukkanen, S. Mannermaa, M.O. Hiltunen, S. Aittomaki, K. Airenne, J. Janne, and S. Yla-Herttuala Local hypomethylation in atherosclerosis found in rabbit EC-SOD gene Arterioscler. Thromb. Vasc. Biol. 19 9 1999 2171 2178
66. - cotransporter 1 in spontaneously hypertensive rats Biochem. Biophys. Res. Commun. 396 2 2010 252 257
67. K.A. Lillycrop, E.S. Phillips, A.A. Jackson, M.A. Hanson, and G.C. Burdge Dietary protein restriction of pregnant rats induces and folic acid supplementation prevents epigenetic modification of hepatic gene expression in the offspring J. Nutr. 135 6 2005 1382 1386
68. K.A. Lillycrop, E.S. Phillips, C. Torrens, M.A. Hanson, A.A. Jackson, and G.C. Burdge Feeding pregnant rats a protein-restricted diet persistently alters the methylation of specific cytosines in the hepatic PPAR alpha promoter of the offspring Br. J. Nutr. 100 2 2008 278 282
69. F. Limana, G. Esposito, D. D'Arcangelo, A. Di Carlo, S. Romani, G. Melillo, A. Mangoni, C. Bertolami, G. Pompilio, A. Germani, and M.C. Capogrossi HMGB1 attenuates cardiac remodelling in the failing heart via enhanced cardiac regeneration and miR-206-mediated inhibition of TIMP-3 PLoS One 6 6 2011 e19845
70. C. Liu, D. Xu, J. Sjoberg, P. Forsell, M. Bjorkholm, and H.E. Claesson Transcriptional regulation of 15-lipoxygenase expression by promoter methylation Exp. Cell Res. 297 1 2004 61 67
71. D.Z. Liu, Y. Tian, B.P. Ander, H. Xu, B.S. Stamova, X. Zhan, R.J. Turner, G. Jickling, and F.R. Sharp Brain and blood microRNA expression profiling of ischemic stroke, intracerebral hemorrhage, and kainate seizures J. Cereb. Blood Flow Metab. 30 1 2010 92 101
72. D. Lloyd-Jones, R. Adams, M. Carnethon, G. De Simone, T.B. Ferguson, K. Flegal, E. Ford, K. Furie, A. Go, K. Greenlund, N. Haase, S. Hailpern, M. Ho, V. Howard, B. Kissela, S. Kittner, D. Lackland, L. Lisabeth, A. Marelli, M. McDermott, J. Meigs, D. Mozaffarian, G. Nichol, C. O'Donnell, V. Roger, W. Rosamond, R. Sacco, P. Sorlie, R. Stafford, J. Steinberger, T. Thom, S. Wasserthiel-Smoller, N. Wong, J. Wylie-Rosett, and Y. Hong Heart disease and stroke statistics-2009 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee Circulation 119 3 2009 480 486
73. G. Lund, L. Andersson, M. Lauria, M. Lindholm, M.F. Fraga, A. Villar-Garea, E. Ballestar, M. Esteller, and S. Zaina DNA methylation polymorphisms precede any histological sign of atherosclerosis in mice lacking apolipoprotein E J. Biol. Chem. 279 28 2004 29147 29154
74. R. Margueron, and D. Reinberg Chromatin structure and the inheritance of epigenetic information Nat. Rev. Genet. 11 4 2010 285 296
75. S.J. Matkovich, D.J. Van Booven, K.A. Youker, G. Torre-Amione, A. Diwan, W.H. Eschenbacher, L.E. Dorn, M.A. Watson, K.B. Margulies, and G.W. Dorn 2nd Reciprocal regulation of myocardial microRNAs and messenger RNA in human cardiomyopathy and reversal of the microRNA signature by biomechanical support Circulation 119 9 2009 1263 1271
76. B. Meder, A. Keller, B. Vogel, J. Haas, F. Sedaghat-Hamedani, E. Kayvanpour, S. Just, A. Borries, J. Rudloff, P. Leidinger, E. Meese, H.A. Katus, and W. Rottbauer MicroRNA signatures in total peripheral blood as novel biomarkers for acute myocardial infarction Basic Res. Cardiol. 106 1 2011 13 23
77. M.E. Mendelsohn, and R.H. Karas The protective effects of estrogen on the cardiovascular system N. Engl. J. Med. 340 23 1999 1801 1811
78. R.M. Millis Epigenetics and hypertension Curr. Hypertens. Rep. 13 1 2011 21 28
79. R.L. Montgomery, T.G. Hullinger, H.M. Semus, B.A. Dickinson, A.G. Seto, J.M. Lynch, C. Stack, P.A. Latimer, E.N. Olson, and E. van Rooij Therapeutic inhibition of miR-208a improves cardiac function and survival during heart failure Circulation 124 14 2011 1537 1547
80. M. Movassagh, M.K. Choy, M. Goddard, M.R. Bennett, T.A. Down, and R.S. Foo Differential DNA methylation correlates with differential expression of angiogenic factors in human heart failure PLoS One 5 1 2010 e8564
81. M. Movassagh, M.K. Choy, D.A. Knowles, L. Cordeddu, S. Haider, T. Down, L. Siggens, A. Vujic, I. Simeoni, C. Penkett, M. Goddard, P. Lio, M.R. Bennett, and R.S. Foo Distinct epigenomic features in end-stage failing human hearts Circulation 124 22 2011 2411 2422
82. M. Movassagh, A. Vujic, and R. Foo Genome-wide DNA methylation in human heart failure Epigenomics 3 1 2011 103 109
83. S.V. Naga Prasad, Z.H. Duan, M.K. Gupta, V.S. Surampudi, S. Volinia, G.A. Calin, C.G. Liu, A. Kotwal, C.S. Moravec, R.C. Starling, D.M. Perez, S. Sen, Q. Wu, E.F. Plow, C.M. Croce, and S. Karnik Unique microRNA profile in end-stage heart failure indicates alterations in specific cardiovascular signaling networks J. Biol. Chem. 284 40 2009 27487 27499
84. F. Olivieri, R. Antonicelli, M. Lorenzi, Y. D'Alessandra, R. Lazzarini, G. Santini, L. Spazzafumo, R. Lisa, L. La Sala, R. Galeazzi, R. Recchioni, R. Testa, G. Pompilio, M.C. Capogrossi, and A.D. Procopio Diagnostic potential of circulating miR-499-5p in elderly patients with acute non ST-elevation myocardial infarction Int. J. Cardiol. 2012
85. Y.B. Ouyang, Y. Lu, S. Yue, L.J. Xu, X.X. Xiong, R.E. White, X. Sun, and R.G. Giffard MiR-181 regulates GRP78 and influences outcome from cerebral ischemia in vitro and in vivo Neurobiol. Dis. 45 1 2012 555 563
86. R.C. Painter, S.R. de Rooij, P.M. Bossuyt, T.A. Simmers, C. Osmond, D.J. Barker, O.P. Bleker, and T.J. Roseboom Early onset of coronary artery disease after prenatal exposure to the Dutch famine Am. J. Clin. Nutr. 84 2 2006 322 327 (quiz 466-327)
87. W.S. Post, P.J. Goldschmidt-Clermont, C.C. Wilhide, A.W. Heldman, M.S. Sussman, P. Ouyang, E.E. Milliken, and J.P. Issa Methylation of the estrogen receptor gene is associated with aging and atherosclerosis in the cardiovascular system Cardiovasc. Res. 43 4 1999 985 991
88. I.A. Qureshi, and M.F. Mehler The emerging role of epigenetics in stroke: II. RNA regulatory circuitry Arch. Neurol. 67 12 2010 1435 1441
89. I.A. Qureshi, and M.F. Mehler Emerging role of epigenetics in stroke: Part 1: DNA methylation and chromatin modifications Arch. Neurol. 67 11 2010 1316 1322
90. I.A. Qureshi, and M.F. Mehler The emerging role of epigenetics in stroke: III. Neural stem cell biology and regenerative medicine Arch. Neurol. 68 3 2011 294 302
91. G. Riviere, D. Lienhard, T. Andrieu, D. Vieau, B.M. Frey, and F.J. Frey Epigenetic regulation of somatic angiotensin-converting enzyme by DNA methylation and histone acetylation Epigenetics 6 4 2011 478 489
92. A.V. Shirodkar, and P.A. Marsden Epigenetics in cardiovascular disease Curr. Opin. Cardiol. 26 3 2011 209 215
93. C. Siegel, J. Li, F. Liu, S.E. Benashski, and L.D. McCullough MiR-23a regulation of X-linked inhibitor of apoptosis (XIAP) contributes to sex differences in the response to cerebral ischemia Proc. Natl. Acad. Sci. USA 108 28 2011 11662 11667
94. B.M. Sondermeijer, A. Bakker, A. Halliani, M.W. de Ronde, A.A. Marquart, A.J. Tijsen, T.A. Mulders, M.G. Kok, S. Battjes, S. Maiwald, S. Sivapalaratnam, M.D. Trip, P.D. Moerland, J.C. Meijers, E.E. Creemers, and S.J. Pinto-Sietsma Platelets in patients with premature coronary artery disease exhibit upregulation of miRNA340 and miRNA624 PLoS One 6 10 2011 e25946
95. C. Sucharov, M.R. Bristow, and J.D. Port MiRNA expression in the failing human heart: functional correlates J. Mol. Cell. Cardiol. 45 2 2008 185 192
96. R.P. Talens, J.W. Jukema, S. Trompet, D. Kremer, R.G. Westendorp, L.H. Lumey, N. Sattar, H. Putter, P.E. Slagboom, and B.T. Heijmans Hypermethylation at loci sensitive to the prenatal environment is associated with increased incidence of myocardial infarction Int. J. Epidemiol. 41 1 2012 106 115
97. K.S. Tan, A. Armugam, S. Sepramaniam, K.Y. Lim, K.D. Setyowati, C.W. Wang, and K. Jeyaseelan Expression profile of MicroRNAs in young stroke patients PLoS One 4 11 2009 e7689
98. T. Thum, P. Galuppo, C. Wolf, J. Fiedler, S. Kneitz, L.W. van Laake, P.A. Doevendans, C.L. Mummery, J. Borlak, A. Haverich, C. Gross, S. Engelhardt, G. Ertl, and J. Bauersachs MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure Circulation 116 3 2007 258 267
99. E.W. Tobi, L.H. Lumey, R.P. Talens, D. Kremer, H. Putter, A.D. Stein, P.E. Slagboom, and B.T. Heijmans DNA methylation differences after exposure to prenatal famine are common and timing- and sex-specific Hum. Mol. Genet. 18 21 2009 4046 4053
100. M.P. Turunen, E. Aavik, and S. Yla-Herttuala Epigenetics and atherosclerosis Biochim. Biophys. Acta 1790 9 2009 886 891
101. G.C. van Almen, W. Verhesen, R.E. van Leeuwen, M. van de Vrie, C. Eurlings, M.W. Schellings, M. Swinnen, J.P. Cleutjens, M.A. van Zandvoort, S. Heymans, and B. Schroen MicroRNA-18 and microRNA-19 regulate CTGF and TSP-1 expression in age-related heart failure Aging Cell 10 5 2011 769 779
102. E. van Rooij, L.B. Sutherland, N. Liu, A.H. Williams, J. McAnally, R.D. Gerard, J.A. Richardson, and E.N. Olson A signature pattern of stress-responsive microRNAs that can evoke cardiac hypertrophy and heart failure Proc. Natl. Acad. Sci. USA 103 48 2006 18255 18260
103. E.M. van Straten, V.W. Bloks, N.C. Huijkman, J.F. Baller, H. van Meer, D. Lutjohann, F. Kuipers, and T. Plosch The liver X-receptor gene promoter is hypermethylated in a mouse model of prenatal protein restriction Am. J. Physiol. Regul. Integr. Comp. Physiol. 298 2 2010 R275 282
104. L.M. Villeneuve, M.A. Reddy, L.L. Lanting, M. Wang, L. Meng, and R. Natarajan Epigenetic histone H3 lysine 9 methylation in metabolic memory and inflammatory phenotype of vascular smooth muscle cells in diabetes Proc. Natl. Acad. Sci. USA 105 26 2008 9047 9052
105. C. Voellenkle, J. van Rooij, C. Cappuzzello, S. Greco, D. Arcelli, L. Di Vito, G. Melillo, R. Rigolini, E. Costa, F. Crea, M.C. Capogrossi, M. Napolitano, and F. Martelli MicroRNA signatures in peripheral blood mononuclear cells of chronic heart failure patients Physiol. Genomics 42 3 2010 420 426
106. G.K. Wang, J.Q. Zhu, J.T. Zhang, Q. Li, Y. Li, J. He, Y.W. Qin, and Q. Jing Circulating microRNA: a novel potential biomarker for early diagnosis of acute myocardial infarction in humans Eur. Heart J. 31 6 2010 659 666
107. R. Wang, N. Li, Y. Zhang, Y. Ran, and J. Pu Circulating MicroRNAs are promising novel biomarkers of acute myocardial infarction Intern. Med. 50 17 2011 1789 1795
108. D.J. Weisenberger, M. Campan, T.I. Long, M. Kim, C. Woods, E. Fiala, M. Ehrlich, and P.W. Laird Analysis of repetitive element DNA methylation by MethyLight Nucleic Acids Res. 33 21 2005 6823 6836
109. H. Weng, C. Shen, G. Hirokawa, X. Ji, R. Takahashi, K. Shimada, C. Kishimoto, and N. Iwai Plasma miR-124 as a biomarker for cerebral infarction Biomed. Res. 32 2 2011 135 141
110. C. Widera, S.K. Gupta, J.M. Lorenzen, C. Bang, J. Bauersachs, K. Bethmann, T. Kempf, K.C. Wollert, and T. Thum Diagnostic and prognostic impact of six circulating microRNAs in acute coronary syndrome J. Mol. Cell. Cardiol. 51 5 2011 872 875
111. J.N. Wilcox, R.R. Subramanian, C.L. Sundell, W.R. Tracey, J.S. Pollock, D.G. Harrison, and P.A. Marsden Expression of multiple isoforms of nitric oxide synthase in normal and atherosclerotic vessels Arterioscler. Thromb. Vasc. Biol. 17 11 1997 2479 2488
112. A.S. Yang, M.R. Estecio, K. Doshi, Y. Kondo, E.H. Tajara, and J.P. Issa A simple method for estimating global DNA methylation using bisulfite PCR of repetitive DNA elements Nucleic Acids Res. 32 3 2004 e38
113. P. Yi, S. Melnyk, M. Pogribna, I.P. Pogribny, R.J. Hine, and S.J. James Increase in plasma homocysteine associated with parallel increases in plasma S-adenosylhomocysteine and lymphocyte DNA hypomethylation J. Biol. Chem. 275 38 2000 29318 29323
114. A.K. Ying, H.H. Hassanain, C.M. Roos, D.J. Smiraglia, J.J. Issa, R.E. Michler, M. Caligiuri, C. Plass, and P.J. Goldschmidt-Clermont Methylation of the estrogen receptor-alpha gene promoter is selectively increased in proliferating human aortic smooth muscle cells Cardiovasc. Res. 46 1 2000 172 179
115. S. Zhu, P.J. Goldschmidt-Clermont, and C. Dong Inactivation of monocarboxylate transporter MCT3 by DNA methylation in atherosclerosis Circulation 112 9 2005 1353 1361
116. M.R. Zile, S.M. Mehurg, J.E. Arroyo, R.E. Stroud, S.M. DeSantis, and F.G. Spinale Relationship between the temporal profile of plasma microRNA and left ventricular remodeling in patients after myocardial infarction Circ. Cardiovasc. Genet. 4 6 2011 614 619
117. M. Ziu, L. Fletcher, S. Rana, D.F. Jimenez, and M. Digicaylioglu Temporal differences in microRNA expression patterns in astrocytes and neurons after ischemic injury PLoS One 6 2 2011 e14724
118. X. Zuo, L. Shen, J.P. Issa, O. Moy, J.S. Morris, S.M. Lippman, and I. Shureiqi 15-Lipoxygenase-1 transcriptional silencing by DNA methyltransferase-1 independently of DNA methylation FASEB J. 22 6 2008 1981 1992