Mobilization of transposons by a mutation abolishing full DNA methylation in Arabidopsis

Nature

Volumn 411, Issue 6834, 2001, Pages 212-214

  Mlura, Asuka ^a   Yonebayashi, Shoji ^b   Watanabe, Koichi ^c   Toyama, Tomoko ^c   Shimada, Hiroaki ^d   Kakutani, Tetsuji ^a,b,c  

^a NATIONAL INSTITUTE OF GENETICS   (Japan)

^b NATIONAL INSTITUTE OF AGROBIOLOGICAL SCIENCES   (Japan)

^c JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^d TOKYO UNIVERSITY OF SCIENCE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

GENES; GENETIC ENGINEERING; MUTAGENESIS; ROOT LOCI;

ARABIDOPSIS;

DNA;

CYTOSINE;

ARABIDOPSIS; ARTICLE; CHROMATIN; DNA METHYLATION; DNA SEQUENCE; DNA TRANSCRIPTION; GENE EXPRESSION; GENE FREQUENCY; GENE INSERTION; GENE LOCUS; GENE MUTATION; GENETIC STABILITY; NONHUMAN; PRIORITY JOURNAL; TRANSPOSON;

ARABIDOPSIS; ARABIDOPSIS PROTEINS; DNA METHYLATION; DNA TRANSPOSABLE ELEMENTS; DNA-BINDING PROTEINS; GENE DOSAGE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENE EXPRESSION REGULATION, PLANT; GENE SILENCING; GENES, PLANT; MOLECULAR SEQUENCE DATA; MUTAGENESIS, INSERTIONAL; MUTATION; PHENOTYPE; PLANT LEAVES; PLANT STEMS; RNA, PLANT; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

ARABIDOPSIS; EMBRYOPHYTA; VERTEBRATA;

EID: 0035837378     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/35075612     Document Type: Article

References (33)

1. SanMiguel, P. et al. Nested retrotransposon in the intergenic region of maize genome. Science 274, 765-768 (1996).
2. Yoder, J. A., Walsh, C. P. & Bestor, T. H. Cytosine methylation and the ecology of intragenomic parasites. Trends Genet. 13, 335-340 (1997).
3. Martienssen, R. Transposons, DNA methylation and gene control. Trends Genet. 14, 263-264 (1998).
4. Walsh, C. P., Chaillet, J. R. & Bestor, T. H. Transcription of IAP endogenous retroviruses is constrained by cytosine methylation. Nature Genet. 20, 116-117 (1998).
5. Matzke, M. A., Mette, M. E, Aufsatz, W., Jakowitsch, J. & Matzke, A. J. Host defenses to parasitic sequences and the evolution of epigenetic control mechanisms. Genetica 107, 271-287 (1999).
6. Vongs, A., Kakutani, T., Martienssen, R. A. & Richards, E. J. Arabidopsis thaliana DNA methylation mutants. Science 260, 1926-1928 (1993).
7. Jeddeloh, J. A., Stokes, T. L. & Richards, E. J. Maintenance of genomic methylation requires a SWI2/ SNF2-like protein. Nature Genet. 22, 94-97 (1999).
8. Mittelsten-Scheid, O., Afsat, K. & Paszkowski, J. Release of epigenetic gene silencing by trans-acting mutations in Arabidopsis. Proc. Natl Acad. Sci. USA 95, 632-637 (1998).
9. Jeddeloh, J. A., Bender, J. & Richards, E. J. The DNA methylation locus DDM1 is required for maintenance of gene silencing in Arabidopsis. Genes Dev. 12, 1714-1725 (1998).
10. Steimer, A. et al. Endogenous targets of transcriptional gene silencing in Arabidopsis. Plant Cell 12, 1165-1178 (2000).
11. Hirochika, H., Okamoto, H. & Kakutani, T. Silencing of retrotransposons in Arabidopsis and reactivation by the ddm1 mutation. Plant Cell 12, 357-369 (2000).
12. Kakutani, T., Jeddeloh, J., Flowers, S., Munakata, K. & Richards, E. Developmental abnormalities and epimutations associated with DNA hypomethylation mutations. Proc. Natl Acad. Sci. USA 93, 12406-12411 (1996).
13. Kakutani, T. Genetic characterization of late-flowering traits induced by DNA hypomethylation mutation in Arabidopsis thaliana. Plant J. 12, 1447-1451 (1997).
14. Soppe, W. et al. The gain of function epi-mutant FWA causes late flowering. Mol. Cell 6, 791-802 (2000).
15. Jacobsen, S., Sakai, H., Finnegan, E., Cao, X. & Meyerowitz, E. Ectopic hypermethylation of flower-specific genes in Arabidopsis. Curr. Biol. 10, 179-186 (2000).
16. Kakutani, T., Munakata K., Richards E. & Hirochika, H. Meiotically and mitotically stable inheritance of DNA hypomethylation induced by ddm1 mutation of Arabidopsis thaliana. Genetics 151, 831-838 (1999).
17. Choe, S. et al. The DWF4 gene of Arabidopsis encodes a cytochrome P450 that mediates multiple 22alpha-hydroxylation steps in brassinosteroid biosynthesis. Plant Cell 10, 231-243 (1998).
18. Siebert, P. D., Chenchik, A., Kellogg, D. E., Lukyanov, K. A. & Lukyanov, S. A. An improved PCR method for walking in uncloned genomic DNA. Nucleic Acids Res. 23, 1087-1088 (1995).
19. Nacken, W. K., Piotrowiak, R., Saedler, H. & Sommer, H. The transposable element Tam1 from Antirrhinum majus shows structural homology to the maize transposon En/Spm and has no sequence specificity of insertion. Mol. Gen. Genet. 228, 201-208 (1991).
20. Chandler, V. L. & Walbot, V. DNA modification of a maize transposable element correlates with loss of activity. Proc. Natl Acad. Sci. USA 83, 1767-1771 (1986).
21. Fedoroff, N. in Epigenetic Mechanisms of Gene Regulation (eds Riggs, A., Martienssen, R. & Russo, V.) 575-592 (Cold Spring Harbor Laboratory Press, Cold Spring Harbor, 1996).
22. Scortecci, K. C., Dessaux, Y., Petit, A. & Van Sluys, M. A. Somatic excision of the Ac transposable element in transgenic Arabidopsis thaliana after 5-azacytidine treatment. Plant Cell Physiol. 38, 336-343 (1997)
23. Lawson, E. J., Scofield, S. R., Sjodin, C., Jones, J. D. & Dean, C. Modification of the 5′ untranslated leader region of the maize Activator element leads to increased activity in Arabidopsis. Mol. Gen. Genet. 245, 608-615 (1994).
24. McClintock, B. Chromosome organization and genie expression. Cold Spring Harbor Symp. Quant. Biol. 16, 13-47 (1951).
25. McClintock, B. The suppressor-mutator system of control of gene action in maize. Carnegie Institution of Washington Year Book 57, 415-429 (1958).
26. Finnegan, E., Peacock, J. & Dennis, E. Reduced DNA methylation in Arabidopsis thaliana results in abnormal plant development. Proc. Natl Acad. Sci. USA 93, 8449-8454 (1996).
27. Ronemus, M, Galbiati, C., Ticknor, J., Chen, J. & Dellaporta, S. Demethylation-induced developmental pleiotropy in Arabidopsis. Science 273, 654-657 (1996).
28. Furner, I. J., Sheikh, M. A. & Collett, C. E. Gene silencing and homology-dependent gene silencing in Arabidopsis. Genetic modifiers and DNA methylation. Genetics 149, 651-662 (1998).
29. Amedeo, P., Habu, Y., Afsar, K., Scheid, O. M. & Paszkowski, J. Disruption of the plant gene MOM releases transcriptional silencing of methylated genes. Nature 405, 203-206 (2000).
30. Mourrain, P. et al. Arabidopsis SGS2 and SGS3 genes are required for posttranscriptional gene silencing and natural virus resistance. Cell 101, 533-542 (2000).
31. Dalmay, T, Hamilton, A., Rudd, S., Angell, S. & Baukombe, D. C. An RNA-dependent RNA polymerase gene in Arabidopsis is required for posttranscriptional gene silencing mediated by a transgene but not by a virus. Cell 101, 543-553 (2000).
32. Fagard, M. et al. AGO1, QDE-2, and RDE-1 are related proteins required for post-transcriptional gene silencing in plants, quelling in fungi, and RNA interference in animals. Proc. Natl Acad. Sci. USA 97, 11650-11654 (2000).
33. Singer, T., Yordan, C. & Martienssen, R. A. Robertson's Mutator transposons in A. thaliana are regulated by the chromatin-remodeling gene Decrease in DNA methylation (DDM1). Genes Dev. 15, 591-602 (2001).