Overexpression of methyl-CpG-binding protein 2 and autoimmunity: Evidence from MECP2 duplication syndrome, lupus, MECP2 transgenic and Mecp2 deficient mice

Lupus

Volumn 22, Issue 9, 2013, Pages 870-872

  Sawalha, A H ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; MESSENGER RNA; METHYL CPG BINDING PROTEIN 2;

ADAPTIVE IMMUNITY; AUTOIMMUNITY; CYTOKINE PRODUCTION; GENE DUPLICATION; GENE LINKAGE DISEQUILIBRIUM; GENE OVEREXPRESSION; GENETIC SUSCEPTIBILITY; HUMAN; LUPUS VULGARIS; LYMPHOCYTE DIFFERENTIATION; NONHUMAN; PRIORITY JOURNAL; REVIEW; T LYMPHOCYTE; TH2 CELL; ANIMAL; IMMUNOLOGY; METABOLISM; TH1 CELL;

ANIMALS; HUMANS; METHYL-CPG-BINDING PROTEIN 2; TH1 CELLS;

EID: 84880899648     PISSN: 09612033     EISSN: 14770962     Source Type: Journal    
DOI: 10.1177/0961203313497119     Document Type: Review

References (24)

1. Jeffries MA, Sawalha AH. Epigenetics in systemic lupus erythematosus: leading the way for specific therapeutic agents. Int J Clin Rheumtol. 2011 ; 6: 423-439
2. Hughes T, Sawalha AH. The role of epigenetic variation in the pathogenesis of systemic lupus erythematosus. Arthritis Res Ther. 2011 ; 13: 245-245
3. Sawalha AH, Webb R, Han S, et al. Common variants within MECP2 confer risk of systemic lupus erythematosus. PloS One. 2008 ; 3: e1727 - e1727
4. Webb R, Wren JD, Jeffries M, et al. Variants within MECP2, a key transcription regulator, are associated with increased susceptibility to lupus and differential gene expression in patients with systemic lupus erythematosus. Arthritis Rheum. 2009 ; 60: 1076-1084
5. Sawalha AH. Xq28 and lupus: IRAK1 or MECP2? Proc Natl Acad Sci U S A 2009; 106: E62; author reply E3. doi: 10.1073/pnas.0904068106.
6. Kaufman KM, Zhao J, Kelly JA, et al. Fine mapping of Xq28: both MECP2 and IRAK1 contribute to risk for systemic lupus erythematosus in multiple ancestral groups. Ann Rheum Dis. 2013 ; 72: 437-444
7. Koelsch KA, Webb R, Jeffries M, et al. Functional characterization of the MECP2/IRAK1 lupus risk haplotype in human T cells and a human MECP2 transgenic mouse. J Autoimmun 2013; 41: 168-74.
8. Yang T, Ramocki MB, Neul JL, et al. Overexpression of methyl-CpG binding protein 2 impairs TH1 responses. Sci Transl Med. 2012 ; 4: 163ra58-163ra58
9. Shahbazian M, Young J, Yuva-Paylor L, et al. Mice with truncated MeCP2 recapitulate many Rett syndrome features and display hyperacetylation of histone H3. Neuron. 2002 ; 35: 243-254
10. Singh R, Singh S, Briles DE, Taub DD, Hollingshead SK, Lillard JW Jr. CCL5-independent helper T lymphocyte responses to immuno-dominant pneumococcal surface protein A epitopes. Vaccine. 2012 ; 30: 1181-1190
11. Palaniappan R, Singh S, Singh UP, et al. CCL5 modulates pneumococcal immunity and carriage. J Immunol. 2006 ; 176: 2346-2356
12. Appay V, Rowland-Jones SL. RANTES: a versatile and controversial chemokine. Trends Immunol. 2001 ; 22: 83-87
13. Sawalha AH. Epigenetics and T-cell immunity. Autoimmunity. 2008 ; 41: 245-252
14. Li Y, Ohms SJ, Shannon FM, Sun C, Fan JY. IL-2 and GM-CSF are regulated by DNA demethylation during activation of T cells, B cells and macrophages. Biochem Biophys Res Commun. 2012 ; 419: 748-753
15. Kimura H, Shiota K. Methyl-CpG-binding protein, MeCP2, is a target molecule for maintenance DNA methyltransferase, Dnmt1. J Biol Chem. 2003 ; 278: 4806-4812
16. Dolff S, Bijl M, Huitema MG, Limburg PC, Kallenberg CG, Abdulahad WH. Disturbed Th1, Th2, Th17 and T(reg) balance in patients with systemic lupus erythematosus. Clin Immunol. 2011 ; 141: 197-204
17. Okamoto A, Fujio K, Tsuno NH, Takahashi K, Yamamoto K. Kidney-infiltrating CD4+ T-cell clones promote nephritis in lupus-prone mice. Kidney Int. 2012 ; 82: 969-979
18. Nagai T, Yanagida T, Hirohata S. Anti-ribosomal P protein antibody induces Th1 responses by enhancing the production of IL-12 in activated monocytes. Mod Rheumatol. 2011 ; 21: 57-62
19. Crowe SR, Merrill JT, Vista ES, et al. Influenza vaccination responses in human systemic lupus erythematosus: impact of clinical and demographic features. Arthritis Rheum. 2011 ; 63: 2396-2406
20. Kaplan MJ. Neutrophils in the pathogenesis and manifestations of SLE. Nat Rev Rheumatol. 2011 ; 7: 691-699
21. Wang N, Hammarstrom L. IgA deficiency: what is new?. Curr Opin Allergy Clin Immunol. 2012 ; 12: 602-608
22. Liu Z, Davidson A. Taming lupus-a new understanding of pathogenesis is leading to clinical advances. Nat Med. 2012 ; 18: 871-882
23. Gordon C, Matthews N, Schlesinger BC, et al. Active systemic lupus erythematosus is associated with the recruitment of naive/resting T cells. Br J Rheumatol. 1996 ; 35: 226-230
24. Fritsch RD, Shen X, Illei GG, et al. Abnormal differentiation of memory T cells in systemic lupus erythematosus. Arthritis Rheum. 2006 ; 54: 2184-2197