Gene reactivation by 5-aza-2′-deoxycytidine-induced demethylation requires srcap-mediated H2A.Z insertion to establish nucleosome depleted regions

PLoS Genetics

Volumn 8, Issue 3, 2012, Pages

  Yang, Xiaojing ^a   Noushmehr, Houtan ^b   Noushmehr, Han ^a,b   Andreu Vieyra, Claudia ^a   Liang, Gangning ^a   Jones, Peter A ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; HISTONE H2AZ; REGULATOR PROTEIN; SNF2 RELATED CBP ACTIVATOR PROTEIN; UNCLASSIFIED DRUG; ADENOSINE TRIPHOSPHATASE; AZACITIDINE; DNA METHYLTRANSFERASE; DRUG DERIVATIVE; HISTONE; HISTONE H2A.F Z; HISTONE H2A.F-Z; SRCAP PROTEIN, HUMAN;

ARTICLE; CHROMATIN; CHROMATIN ASSEMBLY AND DISASSEMBLY; CONTROLLED STUDY; DEMETHYLATION; DNA DEMETHYLATION; DNA METHYLATION; DNA STRUCTURE; EPIGENETICS; GENE ACTIVATION; GENE EXPRESSION; GENE REACTIVATION; GENE SEQUENCE; GENE SILENCING; HUMAN; HUMAN CELL; NUCLEOSOME; NUCLEOSOME DEPLETED REGION; PROMOTER REGION; SEQUENCE ANALYSIS; DRUG ANTAGONISM; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETIC EPIGENESIS; GENETICS; METABOLISM; TRANSCRIPTION INITIATION; TUMOR CELL LINE;

ADENOSINE TRIPHOSPHATASES; AZACITIDINE; CELL LINE, TUMOR; CHROMATIN ASSEMBLY AND DISASSEMBLY; DNA METHYLATION; DNA MODIFICATION METHYLASES; EPIGENESIS, GENETIC; GENE EXPRESSION REGULATION; GENE KNOCKDOWN TECHNIQUES; HISTONES; HUMANS; NUCLEOSOMES; PROMOTER REGIONS, GENETIC; TRANSCRIPTIONAL ACTIVATION;

EID: 84859261580     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1002604     Document Type: Article

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